{"id":75233,"date":"2022-08-08T19:22:00","date_gmt":"2022-08-08T12:22:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022080819220075233"},"modified":"2022-08-08T22:10:59","modified_gmt":"2022-08-08T14:10:59","slug":"%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8e%e9%98%bf%e6%96%af%e5%88%a9%e5%ba%b7%e5%ae%a3%e5%b8%83savannah-ii%e6%9c%9f%e7%a0%94%e7%a9%b6%e4%b8%ad","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022080819220075233","title":{"rendered":"\u548c\u9ec4\u533b\u836f\u4e0e\u963f\u65af\u5229\u5eb7\u5ba3\u5e03SAVANNAH II\u671f\u7814\u7a76\u4e2d"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/HUTCHMED_Logo_Logo-2.jpg\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><p><b>\u6cf0\u745e\u6c99&reg;\uff08TAGRISSO&reg;\uff09\u548c\u8d5b\u6c83\u66ff\u5c3c\uff08savolitinib\uff09\u8054\u5408\u7597\u6cd5\u6cbb\u7597 \u9ad8MET\u8fc7\u8868\u8fbe\u548c\/\u6216\u6269\u589e\u6c34\u5e73\u7684\u80ba\u764c\u60a3\u8005\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe49%<br \/><\/b><\/p>\n<ul type=\"disc\">\n<li><i>MET\u662f\u5bf9\u9776\u5411\u6cbb\u7597\u4ea7\u751f\u8010\u836f\u6027\u7684EGFR\u7a81\u53d8\u80ba\u764c\u60a3\u8005\u4e2d\u6700\u5e38\u89c1\u7684\u751f\u7269\u6807\u5fd7\u7269<\/i><\/li>\n<li><i>\u8bc4<\/i><i>\u4f30<\/i><i>\u8be5\u8054<\/i><i>\u5408<\/i><i>\u7597<\/i><i>\u6cd5<\/i><i>\u7684<\/i><i>SAFFRON\u5168\u7403III\u671f\u7814\u7a76\u6b63\u5728\u8fdb\u884c\u4e2d<\/i><\/li>\n<\/ul>\n<p><span class=\"legendSpanClass\">\u9999\u6e2f\u3001\u4e0a\u6d77\u548c\u65b0\u6cfd\u897f\u5dde\u7279\u4f26\u987f<\/span><span class=\"legendSpanClass\">2022\u5e748\u67088\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u548c\u9ec4\u533b\u836f\uff08\u4e2d\u56fd\uff09\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0&quot;<a href=\"https:\/\/www.hutch-med.com\/sc\/home\/\" target=\"_blank\" rel=\"nofollow noopener\">\u548c\u9ec4\u533b\u836f<\/a>&quot;\u6216&quot;HUTCHMED&quot;\uff09\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u4e0e\u963f\u65af\u5229\u5eb7\uff08LSE\/STO\/Nasdaq: AZN\uff09\u4eca\u5929\u5ba3\u5e03\uff0cSAVANNAH II\u671f\u7814\u7a76\u7684\u521d\u6b65\u7ed3\u679c\u663e\u793a\uff0c\u6cf0\u745e\u6c99&reg;\uff08\u5965\u5e0c\u66ff\u5c3c\/ osimertinib\uff09\u548c\u8d5b\u6c83\u66ff\u5c3c\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u6cf0\u745e\u6c99&reg;\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u3001\u4f34\u6709\u9ad8\u6c34\u5e73\u95f4\u5145\u8d28\u4e0a\u76ae\u8f6c\u5316\u56e0\u5b50\uff08&quot;MET&quot;\uff09\u8fc7\u8868\u8fbe\u548c\/\u6216\u6269\u589e\uff08\u5b9a\u4e49\u4e3aIHC90+\u548c\/\u6216FISH10+\uff09\u7684\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08&quot;EGFR&quot;\uff09\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08&quot;ORR&quot;\uff09\u4e3a49% \uff0895% \u7f6e\u4fe1\u533a\u95f4 [&quot;CI&quot;]\uff0c39-59%\uff09\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1494\">\n<\/p><\/div>\n<p>\u5176\u4e2d\uff0c\u672a\u63a5\u53d7\u8fc7\u5316\u7597\u7684\u9ad8MET\u6c34\u5e73\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u6700\u9ad8\u7684ORR\uff0852% [95% CI\uff0c41-63%]\uff09\u3002\u5728\u672a\u663e\u793a\u9ad8MET\u6c34\u5e73\u7684\u60a3\u8005\u4e2d\uff0cORR\u5219\u4e3a9% (95% CI,4-18%)\u3002\u4e0a\u8ff0\u7814\u7a76\u7ed3\u679c\u5df2\u4e8e2022\u5e748\u67086\u65e5\u81f39\u65e5\u5728\u5965\u5730\u5229\u7ef4\u4e5f\u7eb3\u4e3e\u884c\u7684\u7531\u56fd\u9645\u80ba\u764c\u7814\u7a76\u534f\u4f1a\uff08IASLC\uff09\u4e3b\u529e\u76842022\u5e74\u4e16\u754c\u80ba\u764c\u5927\u4f1a\uff08WCLC\uff09\u4e0a\u516c\u5e03\u3002<\/p>\n<p>\u8d5b\u6c83\u66ff\u5c3c\u5728\u4e2d\u56fd\u4ee5\u5546\u54c1\u540d\u6c83\u745e\u6c99&reg;\u4e0a\u5e02\uff0c\u662f\u4e00\u79cd\u5f3a\u6548\u3001\u9ad8\u9009\u62e9\u6027\u7684\u53e3\u670dMET\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08&quot;TKI&quot;\uff09\uff0c\u7531\u963f\u65af\u5229\u5eb7\u4e0e\u548c\u9ec4\u533b\u836f\u5171\u540c\u5408\u4f5c\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u3002<\/p>\n<p>\u5c3d\u7ba1EGFR\u9776\u5411\u6cbb\u7597\u53ef\u4e3aEGFR\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5e26\u6765\u6301\u4e45\u7684\u751f\u5b58\u83b7\u76ca\uff0c\u7136\u800c\u5927\u591a\u6570\u60a3\u8005\u6700\u7ec8\u4f1a\u5bf9\u5176\u6cbb\u7597\u4ea7\u751f\u8010\u836f\uff0c\u800cMET\u662f\u6700\u5e38\u89c1\u7684\u4e0e\u8010\u836f\u76f8\u5173\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<sup><span id=\"spanHghltf5e9\">[1]<\/span><\/sup> \u6240\u6709\u53c2\u52a0SAVANNAH\u7814\u7a76\u5165\u7ec4\u7b5b\u67e5\u7684\u60a3\u8005\u5747\u5728\u6cf0\u745e\u6c99&reg;\u6cbb\u7597\u540e\u75be\u75c5\u51fa\u73b0\u8fdb\u5c55\uff0c\u5176\u4e2d62%\u60a3\u8005\u7684\u80bf\u7624\u4f34\u6709MET\u8fc7\u8868\u8fbe\u548c\/\u6216\u6269\u589e\uff0c\u8d85\u8fc7\u4e09\u5206\u4e4b\u4e00\uff0834%\uff09\u7684\u60a3\u8005\u7b26\u5408\u5b9a\u4e49\u7684\u9ad8MET\u6c34\u5e73\u9608\u503c\u3002<\/p>\n<p>SAVANNAH II\u671f\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u97e9\u56fd\u9996\u5c14\u6210\u5747\u9986\u5927\u5b66\u533b\u5b66\u9662\u4e09\u661f\u533b\u7597\u4e2d\u5fc3\u5185\u79d1\u8840\u6db2\u53ca\u80bf\u7624\u5b66\u7cfbMyung-Ju Ahn\u6559\u6388\u8868\u793a\uff1a&quot;\u5bf9\u9776\u5411\u6cbb\u7597\u4ea7\u751f\u83b7\u5f97\u6027\u8010\u836f\u5e76\u5bfc\u81f4\u75be\u75c5\u8fdb\u5c55\u662f\u5927\u591a\u6570EGFR\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u90fd\u4f1a\u9762\u4e34\u7684\u8270\u96be\u73b0\u5b9e\u3002SAVANNAH\u7814\u7a76\u7684\u521d\u6b65\u6570\u636e\u6216\u8bb8\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u89e3\u51b3\u65b9\u6cd5\uff0c\u5e2e\u52a9\u8bc6\u522b\u51fa\u6700\u6709\u53ef\u80fd\u4ece\u8d5b\u6c83\u66ff\u5c3c\u7b49\u4ee5MET\u4e3a\u57fa\u7840\u7684\u7597\u6cd5\u4e2d\u83b7\u76ca\u7684MET\u8fc7\u8868\u8fbe\u548c\/\u6216\u6269\u589e\u60a3\u8005\u3002\u8be5\u4e9b\u7814\u7a76\u6570\u636e\u4ea6\u8868\u660e\uff0c\u901a\u8fc7\u5408\u9002\u7684\u751f\u7269\u6807\u5fd7\u7269\u68c0\u6d4b\u7b56\u7565\uff0c MET\u8fd9\u4e00\u9776\u70b9\u5728\u8010\u836f\u60a3\u8005\u4e2d\u6216\u8bb8\u6bd4\u4ee5\u5f80\u8ba4\u4e3a\u7684\u66f4\u52a0\u666e\u904d\uff0c\u4e3a\u5bf9\u5965\u5e0c\u66ff\u5c3c\u548c\u8d5b\u6c83\u66ff\u5c3c\u8054\u5408\u7597\u6cd5\u65b9\u6848\u5f00\u5c55\u8fdb\u4e00\u6b65\u7814\u7a76\u63d0\u4f9b\u4e86\u4f9d\u636e\u3002&quot;<\/p>\n<p>\u963f\u65af\u5229\u5eb7\u9996\u5e2d\u533b\u5b66\u5b98\u517c\u80bf\u7624\u9886\u57df\u9996\u5e2d\u5f00\u53d1\u5b98Cristian Massacesi\u8868\u793a\uff1a&quot;\u76ee\u524d\u5bf9\u63a5\u53d7\u9776\u5411\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684EGFR\u7a81\u53d8\u80ba\u764c\u60a3\u8005\u7684\u6807\u51c6\u6cbb\u7597\u662f\u5316\u7597\u3002SAVANNAH\u7684\u7814\u7a76\u6570\u636e\u8868\u660e\uff0c\u5728\u75be\u75c5\u8fdb\u5c55\u65f6\u5c06\u8d5b\u6c83\u66ff\u5c3c\u8054\u5408\u6cf0\u745e\u6c99&reg;\u4f7f\u7528\uff0c\u6216\u53ef\u4e3a\u8fd9\u4e9b\u7ecf\u751f\u7269\u6807\u5fd7\u7269\u7b5b\u9009\u7684\u60a3\u8005\u63d0\u4f9b\u6bd2\u6027\u66f4\u4f4e\u3001\u66f4\u6709\u6548\u7684\u6f5c\u5728\u6cbb\u7597\u9009\u62e9\u3002\u6211\u4eec\u671f\u5f85\u901a\u8fc7\u8fd9\u9879\u7814\u7a76\u4ee5\u53caSAFFRON III\u671f\u7814\u7a76\uff0c\u66f4\u597d\u5730\u4e86\u89e3\u6cf0\u745e\u6c99&reg;\u548c\u8d5b\u6c83\u66ff\u5c3c\u8054\u5408\u7597\u6cd5\u65b9\u6848\u7684\u6f5c\u529b\u3002&quot;<\/p>\n<p>\u548c\u9ec4\u533b\u836f\u9996\u5e2d\u6267\u884c\u5b98\u517c\u9996\u5e2d\u79d1\u5b66\u5b98\u82cf\u6170\u56fd\u8868\u793a\uff1a&quot;\u6211\u4eec\u5bf9\u8d5b\u6c83\u66ff\u5c3c\u548c\u6cf0\u745e\u6c99&reg;\u8054\u5408\u7597\u6cd5\u65b9\u6848\u8fdb\u5165SAFFRON\u5168\u7403III\u671f\u7814\u7a76\u611f\u5230\u9f13\u821e\uff0c\u5176\u60a3\u8005\u7b5b\u9009\u7b56\u7565\u5f97\u5230\u4e86\u5145\u5206\u7684\u8bc1\u636e\u652f\u6301\uff0c\u6216\u53ef\u4f7f\u6bd4\u9884\u60f3\u66f4\u591a\u7684\u60a3\u8005\u53d7\u76ca\u3002SAVANNAH\u7814\u7a76\u7684\u521d\u6b65\u7ed3\u679c\u4e5f\u80af\u5b9a\u4e86\u5bf9EGFR\u9776\u5411\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5728\u540e\u7eed\u6cbb\u7597\u5f00\u59cb\u524d\u8fdb\u884c\u5206\u5b50\u68c0\u6d4b\u7684\u4f5c\u7528\u3002\u8d5b\u6c83\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u6b64\u7c7b\u60a3\u8005\u7684\u7814\u53d1\u8fc7\u7a0b\u4e2d\uff0c\u6211\u4eec\u4e00\u76f4\u81f4\u529b\u4e8e\u91c7\u7528\u66f4\u5177\u9488\u5bf9\u6027\u3001\u4ee5\u60a3\u8005\u4e3a\u4e2d\u5fc3\u7684\u65b9\u6cd5\u3002&quot;<\/p>\n<p>\u5728\u8be5\u9879\u5206\u6790\u4e2d\uff0c\u60a3\u8005\u7684MET\u8fc7\u8868\u8fbe\u548c\/\u6216\u6269\u589e\u6c34\u5e73\u901a\u8fc7\u4e24\u9879\u6d4b\u8bd5\u786e\u5b9a\uff1a\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u67d3\u8272\u6cd5\uff08&quot;IHC&quot;\uff09\u2014\u2014 \u68c0\u6d4b\u764c\u7ec6\u80de\u8868\u9762\u662f\u5426\u6709\u7279\u5b9a\u86cb\u767d\u8d28\u6216\u6807\u8bb0\u7269\uff1b\u4ee5\u53ca\u8367\u5149\u539f\u4f4d\u6742\u4ea4\uff08&quot;FISH&quot;\uff09\u2014\u2014\u68c0\u6d4b\u764c\u7ec6\u80de\u4e2d\u7279\u5b9a\u7684DNA\u5e8f\u5217\u3002\u8be5\u5206\u6790\u4e2d\u7684\u6240\u6709\u60a3\u8005\uff08n=193\uff09\u81f3\u5c11\u4e3aIHC50+\u548c\/\u6216FISH5+\uff0c\u5e76\u5728\u63a5\u53d7\u6cf0\u745e\u6c99&reg;\u5355\u836f\u6cbb\u7597\u75be\u75c5\u8fdb\u5c55\u540e\uff0c\u572880\u6beb\u514b\u6bcf\u65e5\u4e00\u6b21\u6cf0\u745e\u6c99&reg;\u6cbb\u7597\u57fa\u7840\u4e0a\u52a0\u5165300\u6beb\u514b\u6bcf\u65e5\u4e00\u6b21\u8d5b\u6c83\u66ff\u5c3c\u3002<\/p>\n<p><b>\u7597\u6548\u7ed3\u679c\u603b\u7ed3<\/b><b><sup>i<\/sup><\/b><b>:<\/b><\/p>\n<div>\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"2\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u7ec8\u70b9<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"2\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u5168\u90e8\u60a3\u8005<\/b><b> (IHC50+<\/b><b>\u548c<\/b><b>\/<\/b><b>\u6216<\/b><b>FISH5+; n=193)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"2\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u9ad8<\/b><b>MET<\/b><b>\u6c34\u5e73\u60a3\u8005<\/b><b><sup>ii&nbsp; <\/sup><\/b><b>(IHC90+<\/b><b>\u548c<\/b><b>\/<\/b><b>\u6216<\/b><b>FISH10+)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"2\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u4f4e<\/b><b>MET<\/b><b>\u6c34\u5e73\u60a3\u8005<\/b><b><sup>ii<\/sup><\/b><b>&nbsp;<br \/>(n=77)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6240\u6709<\/span><span class=\"prnews_span\"> (n=108)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u65e0\u65e2\u5f80\u5316\u7597\u53f2<\/span><span class=\"prnews_span\"> (n=87)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>ORR<\/b><b>\uff0c<\/b><b>% (95% CI)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">32 (26, 39)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">49 (39, 59)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">52 (41, 63)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">9 (4, 18)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u4e2d\u4f4d<\/b><b>DoR<sup>iii<\/sup><\/b><b>\uff0c\u6708<\/b>&nbsp;<b>(95% CI)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">8.3 (6.9, 9.7)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">9.3 (7.6, 10.6)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">9.6 (7.6, 14.9)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">6.9 (4.1, 16.9)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u4e2d\u4f4d<\/b><b>PFS<sup>iv<\/sup><\/b><b>\uff0c\u6708<\/b>&nbsp;<b>(95% CI)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">5.3 (4.2, 5.8)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">7.1 (5.3, 8.0)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">7.2 (4.7, 9.2)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">2.8 (2.6, 4.3)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>DCR<sup>v<\/sup><\/b><b>\uff0c<\/b><b>% (95% CI)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">61 (53, 68)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">74 (65, 82)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">75 (64, 83)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">43 (32, 55)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;i.&nbsp;&nbsp;&nbsp; \u5206\u6790\u6570\u636e\u622a\u6b62\u65e5\uff1a2021\u5e748\u670827\u65e5<br \/>ii.&nbsp;&nbsp;&nbsp; \u4e9a\u7ec4\u5206\u6790\u672a\u5305\u62ec\u516b\u540d\u68c0\u6d4b\u7ed3\u679c\u65e0\u6548\u6216\u7f3a\u5931\u7684\u60a3\u8005<br \/>iii.&nbsp;&nbsp;&nbsp; DoR = \u7f13\u89e3\u6301\u7eed\u65f6\u95f4<br \/>iv.&nbsp;&nbsp;&nbsp; PFS = \u65e0\u8fdb\u5c55\u5b58\u6d3b\u671f&nbsp;<br \/>v.&nbsp;&nbsp;&nbsp; DCR = \u75be\u75c5\u63a7\u5236\u7387<\/p>\n<p>\u6cf0\u745e\u6c99&reg;\u548c\u8d5b\u6c83\u66ff\u5c3c\u8054\u5408\u7597\u6cd5\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u5df2\u77e5\u7684\u8054\u5408\u7597\u6cd5\u53ca\u5404\u5355\u836f\u6cbb\u7597\u7684\u5b89\u5168\u6027\u4fdd\u6301\u4e00\u81f4\u3002\u6ca1\u6709\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002\u5728\u8be5\u9879\u5206\u6790\u4e2d\uff0c\u5c11\u4e8e\u534a\u6570\uff0845%\uff09\u7684\u60a3\u8005\u66fe\u7ecf\u53863\u7ea7\u6216\u4ee5\u4e0a\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5176\u4e2d\u6700\u5e38\u89c1\u7684\u5305\u62ec\u80ba\u6813\u585e\u3001\u547c\u5438\u56f0\u96be\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\u548c\u80ba\u708e\u300213%\u7684\u60a3\u8005\u53d1\u751f\u4e0e\u8d5b\u6c83\u66ff\u5c3c\u6cbb\u7597\u76f8\u5173\u7684\u5bfc\u81f4\u505c\u836f\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002<\/p>\n<p>SAFFRON\u5168\u7403III\u671f\u7814\u7a76\u5c06\u8fdb\u4e00\u6b65\u8bc4\u4f30\u6cf0\u745e\u6c99&reg;\u548c\u8d5b\u6c83\u66ff\u5c3c\u8054\u5408\u7597\u6cd5\u5bf9\u6bd4\u94c2\u7c7b\u53cc\u836f\u5316\u7597\uff0c\u7528\u4e8e\u6cbb\u7597\u4f34\u6709EGFR\u7a81\u53d8\u3001MET\u8fc7\u8868\u8fbe\u548c\/\u6216\u6269\u589e\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u7597\u6548\u3002\u6839\u636eSAVANNAH\u7814\u7a76\u4e2d\u786e\u5b9a\u7684\u9608\u503c\uff0c\u4f34\u6709\u9ad8MET\u6c34\u5e73\u7684\u60a3\u8005\u5c06\u88ab\u524d\u77bb\u6027\u5730\u88ab\u7b5b\u9009\u7eb3\u5165\u7814\u7a76\u3002<\/p>\n<p><b>\u5173\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53caMET\u5f02\u5e38<\/b><\/p>\n<p>\u80ba\u764c\u662f\u7537\u6027\u548c\u5973\u6027\u764c\u75c7\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u7ea6\u5360\u6240\u6709\u764c\u75c7\u6b7b\u4ea1\u4eba\u6570\u7684\u4e94\u5206\u4e4b\u4e00\u3002<sup><span id=\"spanHghlt7c7e\">[2]<\/span><\/sup> \u80ba\u764c\u901a\u5e38\u5206\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u548c\u5c0f\u7ec6\u80de\u80ba\u764c\uff08SCLC\uff09\uff0c\u5176\u4e2d80-85%\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<sup><span id=\"spanHghlt45fd\">[3] <\/span><\/sup>\u5927\u90e8\u5206\uff08\u7ea675%\uff09\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5728\u786e\u8bca\u65f6\u5df2\u662f\u665a\u671f\uff0c\u800c \u7f8e\u56fd\u548c\u6b27\u6d32\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7ea6\u670910-25\uff05\u5b58\u5728EGFR\u7a81\u53d8\uff0c\u800c\u4e9a\u6d32\u60a3\u8005\u4e2d\u8be5\u6bd4\u4f8b\u9ad8\u8fbe30-40\uff05\u3002<sup><span id=\"spanHghlt03b1\">[4], [5], [6], [7]<\/span><\/sup><\/p>\n<p>MET\u662f\u4e00\u79cd\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff0c\u5728\u7ec6\u80de\u7684\u6b63\u5e38\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002<sup><span id=\"spanHghlte1af\">[8]<\/span><\/sup> MET\u6269\u589e\u6216\u8fc7\u8868\u8fbe\u53ef\u5bfc\u81f4\u80bf\u7624\u751f\u957f\u4ee5\u53ca\u764c\u7ec6\u80de\u7684\u8f6c\u79fb\u8fdb\u5c55\uff0c\u4e14\u662fEGFR\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5bf9EGFR TKI\u6cbb\u7597\u4ea7\u751f\u83b7\u5f97\u6027\u8010\u836f\u7684\u4e3b\u8981\u673a\u5236\u4e4b\u4e00\u3002<span id=\"spanHghlta0aa\"><sup>[8],<\/sup><sup> [9]<\/sup><\/span> &nbsp;MET\u6269\u589e\u548c\u8fc7\u8868\u8fbe\u7684\u53d1\u751f\u7387\u53ef\u80fd\u56e0\u6837\u54c1\u7c7b\u578b\u3001\u68c0\u6d4b\u65b9\u6cd5\u548c\u4f7f\u7528\u7684\u6d4b\u5b9a\u9608\u503c\u800c\u5f02\u3002<sup><span id=\"spanHghlt67c3\">[10]<\/span><\/sup><\/p>\n<p><b>\u5173\u4e8eSAVANNAH\u7814\u7a76<\/b><\/p>\n<p>SAVANNAH\u7814\u7a76\u662f\u4e00\u9879\u6b63\u5728\u8fdb\u884c\u4e2d\u7684\u968f\u673a\u3001\u5355\u81c2\u3001\u5168\u7403II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u8d5b\u6c83\u66ff\u5c3c\u4e0e\u6cf0\u745e\u6c99&reg;\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u65e2\u5f80\u66fe\u63a5\u53d7\u6cf0\u745e\u6c99&reg;\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684EGFR\u7a81\u53d8\u3001MET\u6269\u589e\u6216\u8fc7\u8868\u8fbe\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002\u60a3\u8005\u6309300\u6beb\u514b\u6216600\u6beb\u514b\u6bcf\u65e5\u4e00\u6b21\uff0c\u6216300\u6beb\u514b\u6bcf\u65e5\u4e24\u6b21\u7684\u5242\u91cf\u63a5\u53d7\u4e86\u8d5b\u6c83\u66ff\u5c3c\u7684\u7ed9\u836f\u6cbb\u7597\uff0c\u8054\u5408\u5965\u5e0c\u66ff\u5c3c80\u6beb\u514b\u6bcf\u65e5\u4e00\u6b21\u7684\u5242\u91cf\u6cbb\u7597\u3002<\/p>\n<p>\u8fc4\u4eca\u4e3a\u6b62\uff0c\u8be5\u7814\u7a76\u5df2\u5728\u5168\u7403\u5305\u62ec\u7f8e\u56fd\u3001\u52a0\u62ff\u5927\u3001\u6b27\u6d32\u3001\u5357\u7f8e\u548c\u4e9a\u6d32\u4e2d\u768480\u591a\u4e2a\u7814\u7a76\u4e2d\u5fc3\u62db\u52df\u4e86294\u540d\u60a3\u8005\u3002\u4e3b\u8981\u7ec8\u70b9\u662fORR\u3002\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u5305\u62ecPFS\u3001DoR\u548c\u5b89\u5168\u6027\u3002<\/p>\n<p><b>\u5173\u4e8e\u6cf0\u745e\u6c99&reg;<\/b><\/p>\n<p>\u6cf0\u745e\u6c99&reg;\uff08\u5965\u5e0c\u66ff\u5c3c\uff09\u662f\u4e00\u79cd\u4e0d\u53ef\u9006\u7684\u7b2c\u4e09\u4ee3EGFR TKI\uff0c\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u5177\u6709\u6297\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u8f6c\u79fb\u7684\u4e34\u5e8a\u6d3b\u6027\u3002\u6cf0\u745e\u6c99&reg;\uff0840mg\u548c80mg\u6bcf\u5929\u4e00\u6b21\u7684\u53e3\u670d\u7247\u5242\uff09\u5df2\u88ab\u7528\u4e8e\u6cbb\u7597\u5168\u7403\u8303\u56f4\u5185\u76f8\u5173\u9002\u5e94\u8bc1\u7684\u5927\u7ea6575,000\u540d\u60a3\u8005\uff0c\u963f\u65af\u5229\u5eb7\u7ee7\u7eed\u63a2\u7d22\u6cf0\u745e\u6c99&reg;\u4f5c\u4e3aEGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e0d\u540c\u5206\u671f\u60a3\u8005\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u6cf0\u745e\u6c99&reg;\u8fd8\u5728\u8fdb\u884c\u591a\u9879\u65b0\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u63a2\u7d22\u5176\u5728\u53ef\u624b\u672f\u5207\u9664\u80ba\u764c\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\uff08NeoADAURA\uff09\u3001IA2-IA3\u671f\u80ba\u764c\u7684\u8f85\u52a9\u6cbb\u7597\uff08ADAURA2\uff09\u3001III\u671f\u653e\u5316\u7597\u540e\u5c40\u90e8\u665a\u671f\u4e0d\u53ef\u624b\u672f\u5207\u9664\u80ba\u764c\u7684\u6cbb\u7597\uff08LAURA\uff09\u4ee5\u53ca\u4e0e\u5316\u7597\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u665a\u671f\u80ba\u764c\uff08FLAURA2\uff09\u4e2d\u7684\u7597\u6548\u3002\u963f\u65af\u5229\u5eb7\u8fd8\u5728\u901a\u8fc7SAVANNAH\u548cORCHARD II\u671f\u7814\u7a76\uff0c\u548c\u6cf0\u745e\u6c99&reg;\u4e0e\u8d5b\u6c83\u66ff\u5c3c\uff08\u4e00\u79cd\u53e3\u670d\u3001\u5f3a\u6548\u548c\u9ad8\u9009\u62e9\u6027MET-TKI\uff09\u8054\u5408\u7597\u6cd5\u7684SAFFRON III\u671f\u7814\u7a76\uff0c\u4ee5\u53ca\u4e0e\u5176\u4ed6\u6f5c\u5728\u65b0\u836f\u7684\u8054\u5408\u7597\u6cd5\uff0c\u4ee5\u63a2\u7d22\u89e3\u51b3\u8010\u836f\u6027\u673a\u5236\u7684\u65b9\u6cd5\u3002<\/p>\n<p><b>\u5173\u4e8e\u8d5b\u6c83\u66ff\u5c3c\uff08\u4e2d\u56fd\u5546\u54c1\u540d\uff1a\u6c83\u745e\u6c99&reg;\uff09<\/b><\/p>\n<p>\u8d5b\u6c83\u66ff\u5c3c\u662f\u4e00\u79cd\u5f3a\u6548\u3001\u9ad8\u9009\u62e9\u6027\u7684\u53e3\u670dMET TKI\uff0c\u5728\u665a\u671f\u5b9e\u4f53\u7624\u4e2d\u8868\u73b0\u51fa\u4e34\u5e8a\u6d3b\u6027\u3002\u8d5b\u6c83\u66ff\u5c3c\u53ef\u963b\u65ad\u56e0\u7a81\u53d8\uff08\u4f8b\u5982\u5916\u663e\u5b5014\u8df3\u8dc3\u7a81\u53d8\u6216\u5176\u4ed6\u70b9\u7a81\u53d8\uff09\u3001\u57fa\u56e0\u6269\u589e\u6216\u86cb\u767d\u8d28\u8fc7\u8868\u8fbe\u800c\u5bfc\u81f4\u7684MET\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u4fe1\u53f7\u901a\u8def\u7684\u5f02\u5e38\u6fc0\u6d3b\u3002<\/p>\n<p>\u8d5b\u6c83\u66ff\u5c3c\u5728\u4e2d\u56fd\u4ee5\u5546\u54c1\u540d\u6c83\u745e\u6c99&reg;\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u63a5\u53d7\u5168\u8eab\u6027\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u65e0\u6cd5\u63a5\u53d7\u5316\u7597\u7684MET\u5916\u663e\u5b5014\u8df3\u8dc3\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002\u76ee\u524d\uff0c\u8d5b\u6c83\u66ff\u5c3c\u6b63\u4f5c\u4e3a\u5355\u836f\u7597\u6cd5\u6216\u4e0e\u5176\u4ed6\u836f\u7269\u7684\u8054\u5408\u7597\u6cd5\uff0c\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u5305\u62ec\u80ba\u764c\u3001\u80be\u764c\u548c\u80c3\u764c\u5728\u5185\u7684\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u3002<\/p>\n<p><b>\u5173\u4e8e\u963f\u65af\u5229\u5eb7\u4e0e\u548c\u9ec4\u533b\u836f\u7684\u5408\u4f5c<\/b><\/p>\n<p>\u548c\u9ec4\u533b\u836f\u4e0e\u963f\u65af\u5229\u5eb7\u4e8e2011\u5e74\u8fbe\u6210\u4e00\u9879\u5168\u7403\u8bb8\u53ef\u548c\u5408\u4f5c\u534f\u8bae\uff0c\u65e8\u5728\u5171\u540c\u5f00\u53d1\u8d5b\u6c83\u66ff\u5c3c\u5e76\u4fc3\u8fdb\u5176\u5546\u4e1a\u5316\u3002\u8d5b\u6c83\u66ff\u5c3c\u5728\u4e2d\u56fd\u7684\u8054\u5408\u5f00\u53d1\u7531\u548c\u9ec4\u533b\u836f\u4e3b\u5bfc\uff0c\u5e76\u7531\u963f\u65af\u5229\u5eb7\u4e3b\u5bfc\u5176\u6d77\u5916\u5f00\u53d1\u3002\u548c\u9ec4\u533b\u836f\u8d1f\u8d23\u8d5b\u6c83\u66ff\u5c3c\u5728\u4e2d\u56fd\u7684\u4e0a\u5e02\u8bb8\u53ef\u3001\u751f\u4ea7\u548c\u4f9b\u5e94\uff0c\u800c\u963f\u65af\u5229\u5eb7\u5219\u8d1f\u8d23\u8d5b\u6c83\u66ff\u5c3c\u5728\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u8303\u56f4\u5185\u7684\u5546\u4e1a\u5316\u3002\u8d5b\u6c83\u66ff\u5c3c\u7684\u9500\u552e\u6536\u5165\u7531\u963f\u65af\u5229\u5eb7\u786e\u8ba4\u3002<\/p>\n<p><b>\u5173\u4e8e\u963f\u65af\u5229\u5eb7\u5728\u80ba\u764c\u9886\u57df\u7684\u7814\u7a76<\/b><\/p>\n<p>\u963f\u65af\u5229\u5eb7\u6b63\u81f4\u529b\u4e8e\u901a\u8fc7\u65e9\u8bca\u65e9\u6cbb\u63d0\u9ad8\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u6108\u7387\uff0c\u540c\u65f6\u63a8\u52a8\u76f8\u5173\u6280\u672f\u4e0d\u65ad\u5411\u524d\u53d1\u5c55\uff0c\u4ee5\u6539\u5584\u4ea7\u751f\u8010\u836f\u6027\u548c\u5904\u4e8e\u665a\u671f\u60c5\u51b5\u4e0b\u7684\u60a3\u8005\u7684\u6cbb\u7597\u7ed3\u679c\u3002\u901a\u8fc7\u5236\u5b9a\u65b0\u7684\u6cbb\u7597\u76ee\u6807\u548c\u8bc4\u4f30\u521b\u65b0\u7597\u6cd5\uff0c\u963f\u65af\u5229\u5eb7\u81f4\u529b\u4e8e\u5b9e\u73b0\u7528\u836f\u60a3\u8005\u53d7\u76ca\u6700\u5927\u5316\u7684\u76ee\u6807\u3002<\/p>\n<p>\u516c\u53f8\u4e30\u5bcc\u7684\u4ea7\u54c1\u7ec4\u5408\u5305\u62ec\u9886\u5148\u7684\u80ba\u764c\u836f\u7269\u4ee5\u53ca\u4e0b\u4e00\u9636\u6bb5\u7684\u521b\u65b0\u836f\u7269\uff0c\u5305\u62ec\u6cf0\u745e\u6c99&reg;\uff08\u5965\u5e0c\u66ff\u5c3c\uff09\u3001\u6613\u745e\u6c99&reg;\uff08\u5409\u975e\u66ff\u5c3c\u7247\uff09\u3001\u82f1\u98de\u51e1&reg;\uff08&nbsp;\u5ea6\u4f10\u5229\u5c24\u5355\u6297\uff09\u548ctremelimumab\uff1b\u4e0e\u7b2c\u4e00\u4e09\u5171\uff08Daiichi Sankyo\uff09\u5408\u4f5c\u7814\u53d1\u7684ENHERTU&reg; (trastuzumab deruxtecan) \u548cdatopotamab deruxtecan\uff1b\u4e0e\u548c\u9ec4\u533b\u836f\u5408\u4f5c\u7814\u53d1\u7684\u8d5b\u6c83\u66ff\u5c3c\uff1b\u540c\u65f6\u8fd8\u6709\u4e00\u7cfb\u5217\u8de8\u8d8a\u4e0d\u540c\u4f5c\u7528\u673a\u5236\u7684\u6f5c\u5728\u65b0\u836f\u548c\u7ec4\u5408\u7684\u4ea7\u54c1\u7ba1\u7ebf\u3002<\/p>\n<p>\u963f\u65af\u5229\u5eb7\u662fLung Ambition Alliance\u7684\u521b\u59cb\u6210\u5458\uff0c\u8be5\u5168\u7403\u6027\u8054\u76df\u81f4\u529b\u4e8e\u52a0\u5feb\u521b\u65b0\u6b65\u4f10\uff0c\u5e77\u4e3a\u80ba\u764c\u60a3\u8005\u63d0\u4f9b\u5305\u62ec\u6cbb\u7597\u548c\u6cbb\u7597\u4ee5\u5916\u7684\u5177\u6709\u610f\u4e49\u7684\u6539\u5584\u63aa\u65bd\u3002<\/p>\n<p><b>\u5173\u4e8e\u963f\u65af\u5229\u5eb7\u80bf\u7624\u9886\u57df\u7684\u7814\u7a76<\/b><\/p>\n<p>\u963f\u65af\u5229\u5eb7\u6b63\u5f15\u9886\u7740\u80bf\u7624\u9886\u57df\u7684\u4e00\u573a\u9769\u547d\uff0c\u81f4\u529b\u63d0\u4f9b\u591a\u5143\u5316\u7684\u80bf\u7624\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u79d1\u5b66\u63a2\u7d22\u80bf\u7624\u9886\u57df\u7684\u590d\u6742\u6027\uff0c\u53d1\u73b0\u3001\u7814\u53d1\u5e76\u5411\u60a3\u8005\u63d0\u4f9b\u6539\u53d8\u751f\u547d\u7684\u836f\u7269\u3002<\/p>\n<p>\u963f\u65af\u5229\u5eb7\u4e13\u6ce8\u4e8e\u6700\u5177\u6311\u6218\u6027\u7684\u80bf\u7624\u75be\u75c5\uff0c\u901a\u8fc7\u6301\u7eed\u4e0d\u65ad\u7684\u521b\u65b0\uff0c\u963f\u65af\u5229\u5eb7\u5df2\u7ecf\u5efa\u7acb\u4e86\u884c\u4e1a\u9886\u5148\u7684\u591a\u5143\u5316\u7684\u4ea7\u54c1\u7ec4\u5408\u548c\u7ba1\u7ebf\uff0c\u6301\u7eed\u63a8\u52a8\u533b\u7597\u5b9e\u8df5\u53d8\u9769\uff0c\u6539\u53d8\u60a3\u8005\u4f53\u9a8c\u3002<\/p>\n<p>\u963f\u65af\u5229\u5eb7\u4ee5\u671f\u91cd\u65b0\u5b9a\u4e49\u764c\u75c7\u6cbb\u7597\u5e76\u5728\u672a\u6765\u653b\u514b\u764c\u75c7\u3002<\/p>\n<p><b>\u5173\u4e8e\u963f\u65af\u5229\u5eb7<\/b><\/p>\n<p>\u963f\u65af\u5229\u5eb7\uff08LSE\/STO\/Nasdaq: AZN\uff09\u662f\u4e00\u5bb6\u79d1\u5b66\u81f3\u4e0a\u7684\u5168\u7403\u6027\u751f\u7269\u5236\u836f\u4f01\u4e1a\uff0c\u4e13\u6ce8\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u53ca\u8425\u9500\u5904\u65b9\u7c7b\u836f\u54c1\uff0c\u91cd\u70b9\u5173\u6ce8\u80bf\u7624\u548c\u5fc3\u8840\u7ba1\u3001\u80be\u810f\u53ca\u4ee3\u8c22\u3001\u547c\u5438\u53ca\u514d\u75ab\u4e09\u5927\u4e3b\u8981\u75be\u75c5\u7684\u751f\u7269\u5236\u836f\u3002\u963f\u65af\u5229\u5eb7\u5168\u7403\u603b\u90e8\u4f4d\u4e8e\u82f1\u56fd\u5251\u6865\uff0c\u4e1a\u52a1\u904d\u5e03\u4e16\u754c100\u591a\u4e2a\u56fd\u5bb6\uff0c\u521b\u65b0\u836f\u7269\u60e0\u53ca\u5168\u7403\u6570\u767e\u4e07\u60a3\u8005\u3002\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a href=\"http:\/\/www.astrazeneca.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.astrazeneca.com<\/a>\u3002<\/p>\n<p><b>\u5173\u4e8e\u548c\u9ec4\u533b\u836f<\/b><\/p>\n<p>\u548c\u9ec4\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\uff0f\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u662f\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u521b\u65b0\u578b\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u3001\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6cbb\u7597\u764c\u75c7\u548c\u514d\u75ab\u6027\u75be\u75c5\u7684\u9776\u5411\u836f\u7269\u548c\u514d\u75ab\u7597\u6cd5\u3002\u96c6\u56e2\u65d7\u4e0b\u516c\u53f8\u5171\u6709\u8d85\u8fc74,900\u540d\u5458\u5de5\uff0c\u5176\u4e2d\u6838\u5fc3\u7684\u80bf\u7624\/\u514d\u75ab\u4e1a\u52a1\u62e5\u6709\u7ea61,800\u4eba\u7684\u56e2\u961f\u3002\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u548c\u9ec4\u533b\u836f\u5728\u5168\u7403\u8303\u56f4\u5185\u5df2\u670913\u4e2a\u81ea\u4e3b\u53d1\u73b0\u7684\u5019\u9009\u836f\u7269\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\uff0c\u5176\u4e2d\u9996\u4e09\u4e2a\u521b\u65b0\u80bf\u7624\u836f\u7269\u73b0\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u8be6\u60c5\uff0c\u8bf7\u8bbf\u95ee\uff1a<a href=\"https:\/\/www.hutch-med.com\/sc\" target=\"_blank\" rel=\"nofollow noopener\">www.hutch\u2011med.com<\/a>\u6216\u5173\u6ce8\u6211\u4eec\u7684<a href=\"https:\/\/www.linkedin.com\/company\/hutchmed\/\" target=\"_blank\" rel=\"nofollow noopener\">\u9886\u82f1<\/a>\u4e13\u9875\u3002<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"0\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prnpr2 prnpl2 prnvab prnsbtb1 prnrbrb1 prnsbbb1 prnsblb1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u53c2\u8003\u6570\u636e<br \/>1.&nbsp;Del MD, et al. Understanding the Mechanisms of Resistance in EGFR-Positive NSCLC: From Tissue to Liquid Biopsy to Guide Treatment Strategy. Int J Mol Sci. 2019;20(16): 3951.<br \/>2.&nbsp;World Health Organization. International Agency for Research on Cancer. All cancers fact sheet. Available at: <a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/39-All-cancers-fact-sheet.pdf.\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/39-All-cancers-fact-sheet.pdf.<\/a> Accessed July 2022.<br \/>3.&nbsp;American Cancer Society. What is Lung Cancer? Available at: <a href=\"https:\/\/www.cancer.org\/cancer\/lung-cancer\/about\/what-is.html.\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/www.cancer.org\/cancer\/lung-cancer\/about\/what-is.html.<\/a> Accessed July 2022.&nbsp;<br \/>4.&nbsp;Knight SB, et al. Progress and prospects of early detection in lung cancer. Open Biol. 2017;7(9): 170070.<br \/>5.&nbsp;Keedy VL, et al. American Society of Clinical Oncology Provisional Clinical Opinion: Epidermal Growth Factor Receptor (EGFR) Mutation Testing for Patients with Advanced Non-Small-Cell Lung Cancer Considering First-Line EGFR Tyrosine Kinase Inhibitor Therapy. J Clin Oncol. 2011:29;2121-27.<br \/>6.&nbsp;Zhang Y, et al. The prevalence of EGFR mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis. Oncotarget. 2016;7(48).<br \/>7. Szumera-Cie\u0107kiewicz A, et al.\u202fEGFR Mutation Testing on Cytological and Histological Samples in 11. Non-Small Cell Lung Cancer: a Polish, Single Institution Study and Systematic Review of European Incidence.&nbsp;Int J Clin Exp Pathol. 2013:6;2800-12.\u202f<br \/>8.&nbsp;Uchikawa E, et al. Structural basis of the activation of c-MET receptor. Nat Commun. 2021;12(4074).<br \/>9.&nbsp;Wang Q, et al. MET inhibitors for targeted therapy of EGFR TKI-resistant lung cancer. Journal of Hematology &amp; Oncology. 2019;63.<br \/>10.&nbsp;Coleman N, et al. Beyond epidermal growth factor receptor: MET amplification as a general resistance driver to targeted therapy in oncogene-driven non-small-cell lung cancer. 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