{"id":75179,"date":"2022-08-06T13:46:00","date_gmt":"2022-08-06T06:46:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022080613460075179"},"modified":"2022-08-06T22:09:44","modified_gmt":"2022-08-06T14:09:44","slug":"%e7%bb%bf%e5%8f%b6%e5%88%b6%e8%8d%af%e5%88%9b%e6%96%b0%e8%8d%aflurbinectedin%e6%ad%a3%e5%bc%8f%e8%90%bd%e5%9c%b0%e6%b5%b7%e5%8d%97","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022080613460075179","title":{"rendered":"\u7eff\u53f6\u5236\u836f\u521b\u65b0\u836fLurbinectedin\u6b63\u5f0f\u843d\u5730\u6d77\u5357"},"content":{"rendered":"

\u7834\u5c40\u590d\u53d1\u6027\u5c0f\u7ec6\u80de\u80ba\u764c\u6cbb\u7597<\/span><\/p>\n

\u4e0a\u6d77<\/span>2022\u5e748\u67086\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u201cLurbinectedin\u767b\u9646\u4e50\u57ce\u53d1\u5e03\u4f1a\u201d\u4e8e8\u67086\u65e5\u76db\u5927\u53ec\u5f00\u3002\u7eff\u53f6\u5236\u836f\u96c6\u56e2\u5728\u4f1a\u4e0a\u5ba3\u5e03\uff0c\u5176\u6297\u80bf\u7624\u521b\u65b0\u836fLurbinectedin\u4f5c\u4e3a\u4e34\u5e8a\u6025\u9700\u836f\u54c1\u6b63\u5f0f\u843d\u5730\u6d77\u5357\u535a\u9ccc\u4e50\u57ce\u56fd\u9645\u533b\u7597\u65c5\u6e38\u5148\u884c\u533a\u7279\u5b9a\u533b\u7597\u673a\u6784\u535a\u9ccc\u672a\u6765\u533b\u9662\uff0c\u7528\u4e8e\u6cbb\u7597\u5728\u542b\u94c2\u7c7b\u5316\u7597\u8fc7\u7a0b\u4e2d\u6216\u5316\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u8f6c\u79fb\u6027\u5c0f\u7ec6\u80de\u80ba\u764c\uff08SCLC\uff09\u6210\u5e74\u60a3\u8005\uff0c\u8fc8\u51fa\u586b\u8865\u56fd\u5185\u590d\u53d1SCLC\u60a3\u8005\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u7684\u7b2c\u4e00\u6b65\u3002<\/p>\n

\u5c71\u4e1c\u7701\u80bf\u7624\u533b\u9662\u4e8e\u91d1\u660e\u9662\u58eb\u3001\u5409\u6797\u7701\u80bf\u7624\u533b\u9662\u7a0b\u9896\u6559\u6388\u3001\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662\u738b\u6d01\u6559\u6388\u3001\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u9644\u5c5e\u80f8\u79d1\u533b\u9662\u97e9\u5b9d\u60e0\u6559\u6388\u3001\u5c71\u4e1c\u7701\u80bf\u7624\u533b\u9662\u738b\u54f2\u6d77\u6559\u6388\u3001\u897f\u73ed\u7259Gregorio Marañón\u5927\u5b66\u7efc\u5408\u533b\u9662Dr. Antonio Calles<\/span> \u3001\u5409\u6797\u7701\u80bf\u7624\u533b\u9662\u5434\u6625\u5a07\u6559\u6388\u3001\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u9644\u5c5e\u80f8\u79d1\u533b\u9662\u5085\u5c0f\u9f99\u6559\u6388\u3001\u6c5f\u82cf\u7701\u4eba\u6c11\u533b\u9662\u675f\u6c38\u524d\u6559\u6388\u3001\u6d59\u6c5f\u7701\u80bf\u7624\u533b\u9662\u8303\u4e91\u6559\u6388\u3001\u4e2d\u5c71\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u5468\u5b81\u5b81\u6559\u6388\u3001\u5b89\u5fbd\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u987e\u5eb7\u751f\u6559\u6388\u3001\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u8d75\u519b\u6559\u6388\u7b49\u4e00\u4f17\u4e13\u5bb6\u5b66\u8005\u4eae\u76f8\u53d1\u5e03\u4f1a\uff0c\u5171\u540c\u63a2\u8ba8Lurbinectedin\u7684\u4e34\u5e8a\u5e94\u7528\u4e0e\u5b9e\u8df5\u3002\u7ebf\u4e0a\u53e6\u6709\u6570\u5343\u540d\u4e13\u5bb6\u5b66\u8005\u53ca\u5609\u5bbe\u53c2\u4e0e\u6b64\u6b21\u542f\u52a8\u4f1a\uff0c\u4e0e\u6d77\u5357\u535a\u9ccc\u4e50\u57ce\u56fd\u9645\u533b\u7597\u65c5\u6e38\u5148\u884c\u533a\u7ba1\u7406\u5c40\u5e38\u52a1\u526f\u5c40\u957f\u5415\u5c0f\u857e\u3001\u7eff\u53f6\u5236\u836f\u96c6\u56e2\u603b\u88c1\u6768\u8363\u5175\u3001\u7eff\u53f6\u5236\u836f\u96c6\u56e2\u526f\u603b\u88c1\u674e\u8389\u7b49\u653f\u5e9c\u548c\u4f01\u4e1a\u4ee3\u8868\u5171\u540c\u89c1\u8bc1\u8fd9\u4e00\u91cc\u7a0b\u7891\u65f6\u523b\u3002<\/p>\n

\u590d\u53d1\u6027<\/b>SCLC<\/b>\u6cbb\u7597\u4e9f\u5f85\u7834\u51b0\uff0c<\/b>Lurbinectedin<\/b>\u5f00\u542f\u65b0\u5c40\u9762<\/b><\/p>\n

\u4e2d\u56fd\u80ba\u764c\u7684\u53d1\u75c5\u7387\u53ca\u6b7b\u4ea1\u7387\u9ad8\u5c45\u764c\u75c7\u4e4b\u9996\uff0c2020\u5e74\u65b0\u53d1\u60a3\u8005\u7ea681.5\u4e07\u4eba\uff0c\u6b7b\u4ea1\u7ea671.4\u4e07\u4eba[1]<\/sup>\uff0c\u5176\u4e2dSCLC\u5360\u80ba\u764c\u768413~17%[2]<\/sup>\u3002SCLC\u60a3\u8005\u786e\u8bca\u65f6\u591a\u4e3a\u665a\u671f\uff0c\u9884\u540e\u6781\u5dee\uff0c\u4e94\u5e74\u751f\u5b58\u7387\u4ec57%\uff0c\u5e7f\u6cdb\u671fSCLC\u7684\u4e94\u5e74\u751f\u5b58\u7387\u4ec53%[3]<\/sup>\u3002\u5c3d\u7ba1SCLC\u5bf9\u4e8e\u521d\u59cb\u6cbb\u7597\u975e\u5e38\u654f\u611f\uff0c\u4f46\u5927\u591a\u6570\u60a3\u8005\u5728\u521d\u59cb\u6cbb\u7597\u540e\u51fa\u73b0\u590d\u53d1\u53ca\u8010\u836f\uff1b\u636e\u7edf\u8ba1\uff0c\u7ea675%\u7684\u5c40\u90e8\u665a\u671f\u60a3\u8005\u548c\u8d85\u8fc790%\u7684\u8f6c\u79fb\u6027\u75be\u75c5\u60a3\u8005\u5728\u6cbb\u75972\u5e74\u5185\u590d\u53d1[4]<\/sup>\u3002SCLC\u7684\u9ad8\u590d\u53d1\u4e3a\u5176\u6cbb\u7597\u5e26\u6765\u5de8\u5927\u6311\u6218\uff0c\u4e34\u5e8a\u4e9f\u9700\u521b\u65b0\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n

Lurbinectedin\u662f\u4e00\u79cd\u9009\u62e9\u6027\u7684\u81f4\u764c\u57fa\u56e0\u8f6c\u5f55\u6291\u5236\u5242\uff0c\u72ec\u7279\u7684\u53cc\u91cd\u4f5c\u7528\u673a\u5236\u4f7f\u5176\u5728\u6291\u5236\u80bf\u7624\u57fa\u56e0\u8f6c\u5f55\u7684\u540c\u65f6\uff0c\u53ef\u8c03\u8282\u80bf\u7624\u5fae\u73af\u5883\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002Lurbinectedin\u4e8e2020\u5e74\u5728\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u83b7\u5f97\u52a0\u901f\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u5728\u542b\u94c2\u7c7b\u5316\u7597\u8fc7\u7a0b\u4e2d\u6216\u5316\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u8f6c\u79fb\u6027SCLC\u6210\u5e74\u60a3\u8005\uff0c\u6210\u4e3a\u8fd1\u4e8c\u5341\u4e94\u5e74\u6765\u9996\u4e2a\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u7684\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6027SCLC\u7684\u65b0\u5206\u5b50\u5b9e\u4f53\u3002<\/p>\n

\u8be5\u83b7\u6279\u4e3b\u8981\u57fa\u4e8eLurbinectedin\u7684\u4e00\u9879\u5355\u836f\u6cbb\u7597105\u4f8b\u63a5\u53d7\u94c2\u7c7b\u836f\u7269\u5316\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684SCLC\u6210\u5e74\u60a3\u8005\uff08\u5305\u62ec\u94c2\u7c7b\u654f\u611f\u548c\u8010\u836f\u60a3\u8005\uff09\u7684\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3\u3001\u5355\u81c2\u3001II\u671f\u7bee\u5b50\u8bd5\u9a8c\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a\u63a5\u53d7Lurbinectedin\u6cbb\u7597\u7684\u60a3\u8005\u603b\u6709\u6548\u7387\uff08Overall Response Rate, ORR\uff09\u8fbe\u523035%\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08Duration of Response, DoR\uff09\u4e3a5.3\u4e2a\u6708\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08Overall Survival, OS\uff09\u4e3a9.3\u4e2a\u6708\u3002\u5176\u4e2d\uff0cLurbinectedin\u5728\u5316\u7597\u654f\u611f\u578b\u60a3\u8005\u7fa4\u4f53\uff08\u505c\u7597\u81f3\u590d\u53d1\u95f4\u9694\uff08CTFI\uff09\u226590\u5929\uff09\u4e2d\u7684\u5355\u836f\u7597\u6548ORR\u53ef\u8fbe45%\uff0c\u4e2d\u4f4dOS\u53ef\u8fbe11.9\u4e2a\u6708\u3002<\/p>\n

\u4e2d\u56fd\u5de5\u7a0b\u9662\u9662\u58eb\u3001\u5c71\u4e1c\u7701\u80bf\u7624\u533b\u9662\u9662\u957f\u4e8e\u91d1\u660e\u6559\u6388\u8868\u793a\uff1a\u201cSCLC\u7684\u6076\u6027\u7a0b\u5ea6\u9ad8\u3001\u4fb5\u88ad\u6027\u9ad8\u3001\u6613\u53d1\u751f\u8010\u836f\u3001\u9884\u540e\u5dee\uff0c\u5728\u4e8c\u7ebf\u6cbb\u7597\u3001\u5c24\u5176\u662f\u96be\u6cbb\u6027SCLC\u7684\u6cbb\u7597\u4ecd\u4e9f\u5f85\u7834\u51b0\u3002\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u7684\u770b\u5230\uff0c\u7eff\u53f6\u5236\u836f\u6cbb\u7597SCLC\u7684\u521b\u65b0\u836fLurbinectedin\u6b63\u5f0f\u843d\u5730\u4e50\u57ce\u5148\u884c\u533a\uff0c\u8fd9\u5c06\u4e3a\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/p>\n

\u4e2d\u56fd\u4e34\u5e8a\u7814\u7a76<\/b>ORR<\/b>\u8fbe<\/b>45.5%<\/b>\uff0c\u63d0\u793a\u4e2d\u56fd\u4eba\u7fa4\u83b7\u76ca\u66f4\u663e\u8457<\/b><\/p>\n

\u4eca\u5e74\u7684\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\uff0c\u201cLurbinectedin\u4e8c\u7ebf\u6cbb\u7597\u4e2d\u56fdSCLC\u60a3\u8005\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u521d\u6b65\u7ed3\u679c\u201d\u4ea6\u83b7\u5f97\u4e13\u5bb6\u5b66\u8005\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u7814\u7a76\u7ed3\u679c\u63d0\u793a\uff1aLurbinectedin\uff083.2 mg\/\u33a1\uff09\u5728\u4e2d\u56fdSCLC\u60a3\u8005\u7fa4\u4f53\u7684\u4e8c\u7ebf\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u79ef\u6781\u7684\u7597\u6548\u6f5c\u529b\uff1a\u7531\u72ec\u7acb\u8bc4\u5ba1\u59d4\u5458\u4f1a\u8bc4\u4f30\u786e\u8ba4\u7684ORR\u4e3a45.5%\uff0c\u5176\u4e2d\uff0c\u5728\u96be\u6cbb\u6027SCLC\u53d7\u8bd5\u8005\u4e2d\u8d85\u8fc730%\uff1b\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08Progression-Free Survival\uff0cPFS\uff09\u4e3a6.6\u4e2a\u6708\u3002\u6b64\u5916\uff0cLurbinectedin\u8868\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u4e0e\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002<\/p>\n

\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5409\u6797\u7701\u80bf\u7624\u533b\u9662\u515a\u59d4\u4e66\u8bb0\u3001\u5409\u6797\u7701\u764c\u75c7\u4e2d\u5fc3\u4e3b\u4efb\u7a0b\u9896\u6559\u6388\u8868\u793a\uff1a\u201c\u4e0a\u8ff0\u7814\u7a76\u9996\u6b21\u5728\u4e2d\u56fd\u4eba\u7fa4\u4e2d\u63a2\u7d22\u4e86Lurbinectedin\u7684\u521d\u6b65\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u6211\u4eec\u770b\u5230\uff0cLurbinectedin\u5728\u4e00\u7ebf\u542b\u94c2\u5316\u7597\u51fa\u73b0\u8fdb\u5c55\u7684\u4e2d\u56fd\u590d\u53d1\u6027SCLC\u4eba\u7fa4\u4e2d\u7684\u7597\u6548\u4e0e\u56fd\u5916II\u671f\u4e34\u5e8a\u8bd5\u9a8cSCLC\u961f\u5217\u7684\u7597\u6548\u7ed3\u679c\u6709\u53ef\u6bd4\u6027\uff0c\u5e76\u503e\u5411\u4e8e\u83b7\u5f97\u66f4\u597d\u7684\u6709\u6548\u7387\u3002\u76f8\u4fe1Lurbinectedin\u843d\u5730\u535a\u9ccc\u4e50\u57ce\u80fd\u591f\u63a8\u52a8\u8fd9\u4e00\u521b\u65b0\u6cbb\u7597\u65b9\u6848\u5728\u4e2d\u56fd\u7684\u53ef\u53ca\u6027\u3002\u201d<\/p>\n

\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662\u5185\u79d1\u4e3b\u4efb\u738b\u6d01\u6559\u6388\u4e5f\u5728\u4f1a\u4e0a\u6307\u51fa\uff1a\u201cLurbinectedin\u7684II\u671f\u7bee\u5b50\u8bd5\u9a8c\u6570\u636e\u53d1\u5e03\u540e\uff0c\u4e3a\u590d\u53d1SCLC\u6cbb\u7597\u7684\u60a3\u8005\u5e26\u6765\u4e86\u65b0\u7684\u5e0c\u671b\u3002\u5728\u4eca\u5e74ASCO\u5e74\u4f1a\u4e0a\uff0c\u6211\u4eec\u6b23\u559c\u7684\u770b\u5230Lurbinectedin\u5728\u4e2d\u56fd\u60a3\u8005\u7fa4\u4f53\u4e2d\u7684\u7597\u6548\u83b7\u76ca\u66f4\u4e3a\u660e\u663e\u3002\u6211\u4eec\u671f\u5f85\u8be5\u836f\u7269\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\u53d1\u6325\u51fa\u66f4\u597d\u7684\u4f5c\u7528\u3002\u201d<\/p>\n

\u9664\u4e86\u5355\u836f\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\uff0c Lurbinectedin\u5728\u56fd\u9645\u4e0a\u4ea6\u5f00\u5c55\u4e86\u591a\u9879\u8054\u5408\u7528\u836f\u7814\u7a76\u3002\u5728\u9898\u4e3a\u201cLurbinectedin\u4e2d\u56fd\u4e34\u5e8a\u5e94\u7528\u5706\u684c\u8bba\u575b\u201d\u73af\u8282\u4e2d\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u9644\u5c5e\u80f8\u79d1\u533b\u9662\u547c\u5438\u5185\u79d1\u5b66\u79d1\u4e3b\u4efb\u97e9\u5b9d\u60e0\u6559\u6388\u6307\u51fa\uff1a\u201cLurbinectedin\u83b7\u5f97\u4e86\u4e8c\u7ebf\u6cbb\u7597\u7684\u9002\u5e94\u75c7\u540e\uff0c\u8fd8\u6709\u5f88\u5927\u7684\u62d3\u5c55\u7a7a\u95f4\uff0c\u5305\u62ec\u8054\u5408\u5316\u7597\u3001\u514d\u75ab\u6cbb\u7597\u3001\u653e\u7597\u4ee5\u53ca\u5404\u79cd\u5176\u4ed6\u65b0\u578b\u7684\u8054\u7528\u7ec4\u5408\u3002\u5728\u8054\u7528\u8fc7\u7a0b\u4e2d\uff0c\u53ef\u4ee5\u63a2\u7d22\u66f4\u591a\u517c\u987e\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u7684\u8054\u5408\u6cbb\u7597\u7684\u7b56\u7565\uff0c\u9020\u798f\u66f4\u591aSCLC\u60a3\u8005\u3002\u201d\u5706\u684c\u8bba\u575b\u4e0a\uff0c\u5085\u5c0f\u9f99\u6559\u6388\u3001\u675f\u6c38\u524d\u6559\u6388\u3001\u8303\u4e91\u6559\u6388\u3001\u5468\u5b81\u5b81\u6559\u6388\u3001\u987e\u5eb7\u751f\u6559\u6388\u3001\u8d75\u519b\u6559\u6388\u7b49\u4e34\u5e8a\u5927\u5496\u4ea6\u5404\u6292\u5df1\u89c1\uff0c\u56f4\u7ed5Lurbinectedin\u7684\u63a8\u8350\u5242\u91cf\u3001\u8054\u7528\u65b9\u6848\u5c55\u5f00\u70ed\u8bae\u3002<\/p>\n

\u843d\u5730\u6d77\u5357\u201c\u5148\u8bd5\u5148\u884c\u201d\uff0c\u52a0\u901f\u60e0\u53ca\u4e2d\u56fd\u60a3\u8005<\/b><\/p>\n

\u83b7\u76ca\u4e8e\u6d77\u5357\u81ea\u7531\u8d38\u6613\u6e2f\u4e00\u7cfb\u5217\u201c\u5148\u884c\u5148\u8bd5\u201d\u653f\u7b56\uff0cLurbinectedin\u7387\u5148\u843d\u5730\u535a\u9ccc\u4e50\u57ce\u5148\u884c\u533a\u7279\u5b9a\u533b\u7597\u673a\u6784\u535a\u9ccc\u672a\u6765\u533b\u9662\u6295\u5165\u4e34\u5e8a\u4f7f\u7528\uff0c\u4f7f\u4e2d\u56fd\u60a3\u8005\u4e0d\u51fa\u56fd\u95e8\u4ea6\u80fd\u83b7\u76ca\u4e8e\u8fd9\u4e00\u56fd\u9645\u5148\u8fdb\u7684\u6cbb\u7597\u65b0\u65b9\u6848\u3002<\/p>\n

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\u53c2\u8003\u6587\u732e\uff1a<\/p>\n

\n\n\n\n\n\n\n
\n

[1].<\/sup> International Agency for Research on Cancer \u2013 Population Fact Sheets \u2013 China. Available at https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf<\/a>. Accessed in August 2022.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[2].<\/sup> \u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u6307\u5357\u5de5\u4f5c\u59d4\u5458\u4f1a. \u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u5c0f\u7ec6\u80de\u80ba\u764c\u8bca\u7597\u6307\u53572022. \u4eba\u6c11\u536b\u751f\u51fa\u7248\u793e. 2022<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[3]. <\/sup>Cancer.Net. Lung Cancer – Small Cell. Available at https:\/\/www.cancer.net\/cancer-types\/33776\/view-all. Accessed in August 2022.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[4].<\/sup> Rudin CM, et al. Nat Rev Dis Primers. 2021 Jan 14;7(1):3.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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\u590d\u53d1\u6027SCLC\u6cbb\u7597\u4e9f\u5f85\u7834\u51b0\uff0cLurbinectedin\u5f00\u542f\u65b0\u5c40\u9762 \u4e2d\u56fd\u80ba\u764c\u7684\u53d1\u75c5\u7387\u53ca\u6b7b\u4ea1\u7387\u9ad8\u5c45\u764c\u75c7\u4e4b\u9996\uff0c2020\u5e74\u65b0\u53d1\u60a3\u8005\u7ea681.5\u4e07\u4eba\uff0c\u6b7b\u4ea1\u7ea671.4\u4e07\u4eba[1]\uff0c\u5176\u4e2dSCLC\u5360\u80ba\u764c\u768413~17%[2]\u3002SCLC\u60a3\u8005\u786e\u8bca\u65f6\u591a\u4e3a\u665a\u671f\uff0c\u9884\u540e\u6781\u5dee\uff0c\u4e94\u5e74\u751f\u5b58\u7387\u4ec57%\uff0c\u5e7f\u6cdb\u671fSCLC\u7684\u4e94\u5e74\u751f\u5b58\u7387\u4ec53%[3]\u3002\u5c3d\u7ba1SCLC\u5bf9\u4e8e\u521d\u59cb\u6cbb\u7597\u975e\u5e38\u654f\u611f\uff0c\u4f46\u5927\u591a\u6570\u60a3\u8005\u5728\u521d\u59cb\u6cbb\u7597\u540e\u51fa\u73b0\u590d\u53d1\u53ca\u8010\u836f\uff1b\u636e\u7edf\u8ba1\uff0c\u7ea675%\u7684\u5c40\u90e8\u665a\u671f\u60a3\u8005\u548c\u8d85\u8fc790%\u7684\u8f6c\u79fb\u6027\u75be\u75c5\u60a3\u8005\u5728\u6cbb\u75972\u5e74\u5185\u590d\u53d1[4]\u3002SCLC\u7684\u9ad8\u590d\u53d1\u4e3a\u5176\u6cbb\u7597\u5e26\u6765\u5de8\u5927\u6311\u6218\uff0c\u4e34\u5e8a\u4e9f\u9700\u521b\u65b0\u6cbb\u7597\u65b9\u6848\u3002 Lurbinectedin\u662f\u4e00\u79cd\u9009\u62e9\u6027\u7684\u81f4\u764c\u57fa\u56e0\u8f6c\u5f55\u6291\u5236\u5242\uff0c\u72ec\u7279\u7684\u53cc\u91cd\u4f5c\u7528\u673a\u5236\u4f7f\u5176\u5728\u6291\u5236\u80bf\u7624\u57fa\u56e0\u8f6c\u5f55\u7684\u540c\u65f6\uff0c\u53ef\u8c03\u8282\u80bf\u7624\u5fae\u73af\u5883\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002Lurbinectedin\u4e8e2020\u5e74\u5728\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u83b7\u5f97\u52a0\u901f\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u5728\u542b\u94c2\u7c7b\u5316\u7597\u8fc7\u7a0b\u4e2d\u6216\u5316\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u8f6c\u79fb\u6027SCLC\u6210\u5e74\u60a3\u8005\uff0c\u6210\u4e3a\u8fd1\u4e8c\u5341\u4e94\u5e74\u6765\u9996\u4e2a\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u7684\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6027SCLC\u7684\u65b0\u5206\u5b50\u5b9e\u4f53\u3002 \u8be5\u83b7\u6279\u4e3b\u8981\u57fa\u4e8eLurbinectedin\u7684\u4e00\u9879\u5355\u836f\u6cbb\u7597105\u4f8b\u63a5\u53d7\u94c2\u7c7b\u836f\u7269\u5316\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684SCLC\u6210\u5e74\u60a3\u8005\uff08\u5305\u62ec\u94c2\u7c7b\u654f\u611f\u548c\u8010\u836f\u60a3\u8005\uff09\u7684\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3\u3001\u5355\u81c2\u3001II\u671f\u7bee\u5b50\u8bd5\u9a8c\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a\u63a5\u53d7Lurbinectedin\u6cbb\u7597\u7684\u60a3\u8005\u603b\u6709\u6548\u7387\uff08Overall Response Rate, ORR\uff09\u8fbe\u523035%\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08Duration of Response, DoR\uff09\u4e3a5.3\u4e2a\u6708\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08Overall Survival, OS\uff09\u4e3a9.3\u4e2a\u6708\u3002\u5176\u4e2d\uff0cLurbinectedin\u5728\u5316\u7597\u654f\u611f\u578b\u60a3\u8005\u7fa4\u4f53\uff08\u505c\u7597\u81f3\u590d\u53d1\u95f4\u9694\uff08CTFI\uff09\u226590\u5929\uff09\u4e2d\u7684\u5355\u836f\u7597\u6548ORR\u53ef\u8fbe45%\uff0c\u4e2d\u4f4dOS\u53ef\u8fbe11.9\u4e2a\u6708\u3002 \u4e2d\u56fd\u5de5\u7a0b\u9662\u9662\u58eb\u3001\u5c71\u4e1c\u7701\u80bf\u7624\u533b\u9662\u9662\u957f\u4e8e\u91d1\u660e\u6559\u6388\u8868\u793a\uff1a\u201cSCLC\u7684\u6076\u6027\u7a0b\u5ea6\u9ad8\u3001\u4fb5\u88ad\u6027\u9ad8\u3001\u6613\u53d1\u751f\u8010\u836f\u3001\u9884\u540e\u5dee\uff0c\u5728\u4e8c\u7ebf\u6cbb\u7597\u3001\u5c24\u5176\u662f\u96be\u6cbb\u6027SCLC\u7684\u6cbb\u7597\u4ecd\u4e9f\u5f85\u7834\u51b0\u3002\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u7684\u770b\u5230\uff0c\u7eff\u53f6\u5236\u836f\u6cbb\u7597SCLC\u7684\u521b\u65b0\u836fLurbinectedin\u6b63\u5f0f\u843d\u5730\u4e50\u57ce\u5148\u884c\u533a\uff0c\u8fd9\u5c06\u4e3a\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d \u4e2d\u56fd\u4e34\u5e8a\u7814\u7a76ORR\u8fbe45.5%\uff0c\u63d0\u793a\u4e2d\u56fd\u4eba\u7fa4\u83b7\u76ca\u66f4\u663e\u8457 \u4eca\u5e74\u7684\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\uff0c\u201cLurbinectedin\u4e8c\u7ebf\u6cbb\u7597\u4e2d\u56fdSCLC\u60a3\u8005\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u521d\u6b65\u7ed3\u679c\u201d\u4ea6\u83b7\u5f97\u4e13\u5bb6\u5b66\u8005\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u7814\u7a76\u7ed3\u679c\u63d0\u793a\uff1aLurbinectedin\uff083.2 mg\/\u33a1\uff09\u5728\u4e2d\u56fdSCLC\u60a3\u8005\u7fa4\u4f53\u7684\u4e8c\u7ebf\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u79ef\u6781\u7684\u7597\u6548\u6f5c\u529b\uff1a\u7531\u72ec\u7acb\u8bc4\u5ba1\u59d4\u5458\u4f1a\u8bc4\u4f30\u786e\u8ba4\u7684ORR\u4e3a45.5%\uff0c\u5176\u4e2d\uff0c\u5728\u96be\u6cbb\u6027SCLC\u53d7\u8bd5\u8005\u4e2d\u8d85\u8fc730%\uff1b\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08Progression-Free Survival\uff0cPFS\uff09\u4e3a6.6\u4e2a\u6708\u3002\u6b64\u5916\uff0cLurbinectedin\u8868\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u4e0e\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002 \u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5409\u6797\u7701\u80bf\u7624\u533b\u9662\u515a\u59d4\u4e66\u8bb0\u3001\u5409\u6797\u7701\u764c\u75c7\u4e2d\u5fc3\u4e3b\u4efb\u7a0b\u9896\u6559\u6388\u8868\u793a\uff1a\u201c\u4e0a\u8ff0\u7814\u7a76\u9996\u6b21\u5728\u4e2d\u56fd\u4eba\u7fa4\u4e2d\u63a2\u7d22\u4e86Lurbinectedin\u7684\u521d\u6b65\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u6211\u4eec\u770b\u5230\uff0cLurbinectedin\u5728\u4e00\u7ebf\u542b\u94c2\u5316\u7597\u51fa\u73b0\u8fdb\u5c55\u7684\u4e2d\u56fd\u590d\u53d1\u6027SCLC\u4eba\u7fa4\u4e2d\u7684\u7597\u6548\u4e0e\u56fd\u5916II\u671f\u4e34\u5e8a\u8bd5\u9a8cSCLC\u961f\u5217\u7684\u7597\u6548\u7ed3\u679c\u6709\u53ef\u6bd4\u6027\uff0c\u5e76\u503e\u5411\u4e8e\u83b7\u5f97\u66f4\u597d\u7684\u6709\u6548\u7387\u3002\u76f8\u4fe1Lurbinectedin\u843d\u5730\u535a\u9ccc\u4e50\u57ce\u80fd\u591f\u63a8\u52a8\u8fd9\u4e00\u521b\u65b0\u6cbb\u7597\u65b9\u6848\u5728\u4e2d\u56fd\u7684\u53ef\u53ca\u6027\u3002\u201d \u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662\u5185\u79d1\u4e3b\u4efb\u738b\u6d01\u6559\u6388\u4e5f\u5728\u4f1a\u4e0a\u6307\u51fa\uff1a\u201cLurbinectedin\u7684II\u671f\u7bee\u5b50\u8bd5\u9a8c\u6570\u636e\u53d1\u5e03\u540e\uff0c\u4e3a\u590d\u53d1SCLC\u6cbb\u7597\u7684\u60a3\u8005\u5e26\u6765\u4e86\u65b0\u7684\u5e0c\u671b\u3002\u5728\u4eca\u5e74ASCO\u5e74\u4f1a\u4e0a\uff0c\u6211\u4eec\u6b23\u559c\u7684\u770b\u5230Lurbinectedin\u5728\u4e2d\u56fd\u60a3\u8005\u7fa4\u4f53\u4e2d\u7684\u7597\u6548\u83b7\u76ca\u66f4\u4e3a\u660e\u663e\u3002\u6211\u4eec\u671f\u5f85\u8be5\u836f\u7269\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\u53d1\u6325\u51fa\u66f4\u597d\u7684\u4f5c\u7528\u3002\u201d \u9664\u4e86\u5355\u836f\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\uff0c Lurbinectedin\u5728\u56fd\u9645\u4e0a\u4ea6\u5f00\u5c55\u4e86\u591a\u9879\u8054\u5408\u7528\u836f\u7814\u7a76\u3002\u5728\u9898\u4e3a\u201cLurbinectedin\u4e2d\u56fd\u4e34\u5e8a\u5e94\u7528\u5706\u684c\u8bba\u575b\u201d\u73af\u8282\u4e2d\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u9644\u5c5e\u80f8\u79d1\u533b\u9662\u547c\u5438\u5185\u79d1\u5b66\u79d1\u4e3b\u4efb\u97e9\u5b9d\u60e0\u6559\u6388\u6307\u51fa\uff1a\u201cLurbinectedin\u83b7\u5f97\u4e86\u4e8c\u7ebf\u6cbb\u7597\u7684\u9002\u5e94\u75c7\u540e\uff0c\u8fd8\u6709\u5f88\u5927\u7684\u62d3\u5c55\u7a7a\u95f4\uff0c\u5305\u62ec\u8054\u5408\u5316\u7597\u3001\u514d\u75ab\u6cbb\u7597\u3001\u653e\u7597\u4ee5\u53ca\u5404\u79cd\u5176\u4ed6\u65b0\u578b\u7684\u8054\u7528\u7ec4\u5408\u3002\u5728\u8054\u7528\u8fc7\u7a0b\u4e2d\uff0c\u53ef\u4ee5\u63a2\u7d22\u66f4\u591a\u517c\u987e\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u7684\u8054\u5408\u6cbb\u7597\u7684\u7b56\u7565\uff0c\u9020\u798f\u66f4\u591aSCLC\u60a3\u8005\u3002\u201d\u5706\u684c\u8bba\u575b\u4e0a\uff0c\u5085\u5c0f\u9f99\u6559\u6388\u3001\u675f\u6c38\u524d\u6559\u6388\u3001\u8303\u4e91\u6559\u6388\u3001\u5468\u5b81\u5b81\u6559\u6388\u3001\u987e\u5eb7\u751f\u6559\u6388\u3001\u8d75\u519b\u6559\u6388\u7b49\u4e34\u5e8a\u5927\u5496\u4ea6\u5404\u6292\u5df1\u89c1\uff0c\u56f4\u7ed5Lurbinectedin\u7684\u63a8\u8350\u5242\u91cf\u3001\u8054\u7528\u65b9\u6848\u5c55\u5f00\u70ed\u8bae\u3002 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\u53c2\u8003\u6587\u732e\uff1a [1]. International Agency for Research on Cancer \u2013 Population Fact Sheets \u2013 China. Available at https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf. 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