{"id":75016,"date":"2022-08-05T11:09:00","date_gmt":"2022-08-05T04:09:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022080511090075016"},"modified":"2022-08-05T22:10:04","modified_gmt":"2022-08-05T14:10:04","slug":"2022-wclc-%e8%bf%aa%e5%93%b2%e8%88%92%e6%b2%83%e6%9b%bf%e5%b0%bc%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%e7%bb%93%e6%9e%9c%e5%96%9c%e4%ba%ba","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022080511090075016","title":{"rendered":"2022 WCLC | \u8fea\u54f2\u8212\u6c83\u66ff\u5c3c\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u559c\u4eba"},"content":{"rendered":"<p><p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2022\u5e748\u67085\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u6628\u65e5\uff0c\u8fea\u54f2\u533b\u836f\u5728<span id=\"spanHghlt557f\">\u7b2c23\u5c4a<\/span>\u4e16\u754c\u80ba\u764c\u5927\u4f1a\uff08WCLC\uff09\u516c\u5e03\u4e86<b>\u81ea\u4e3b\u7814\u53d1\u7684\u56fd\u5bb6<\/b><b>I<\/b><b>\u7c7b\u65b0\u836f &#8212; \u8212\u6c83\u66ff\u5c3c<\/b>\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u542b\u94c2\u5316\u7597\u5931\u8d25\u7684EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u578b\uff08EGFR exon20ins\uff09\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u6700\u65b0\u7814\u7a76\u6210\u679c\u3002<\/p>\n<p>\u8212\u6c83\u66ff\u5c3c\u662f\u4e00\u6b3e\u53e3\u670d\u3001\u4e0d\u53ef\u9006\u3001\u9488\u5bf9\u591a\u79cdEGFR\u7a81\u53d8\u4e9a\u578b\u7684\u9ad8\u9009\u62e9\u6027EGFR\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\uff0c\u51ed\u501f\u4f18\u79c0\u7684\u7814\u7a76\u6210\u679c\u6210\u4e3a<b>\u80ba\u764c\u9886\u57df\u9996\u4e2a\u3001\u4e14\u76ee\u524d\u552f\u4e00\u83b7\u5f97\u4e2d\u3001\u7f8e\u53cc&quot;\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a&quot;\u7684\u56fd\u521b\u65b0\u836f<\/b>\uff0c\u73b0\u5904\u4e8e\u5168\u7403\u5173\u952e\u6027\u6ce8\u518c\u4e34\u5e8a\u9636\u6bb5\u3002<\/p>\n<p>\u672c\u6b21WCLC\u4f1a\u8bae\u4e0a\u62a5\u9053\u7684\u66f4\u65b0\u6570\u636e\u6765\u81ea\u8212\u6c83\u66ff\u5c3c\u4e09\u9879I\/II\u671f\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\uff08WU-KONG1\u3001WU-KONG2\u548cWU-KONG6\uff09\u7684\u6c47\u603b\u5206\u6790\u3002<\/p>\n<p class=\"prnml4\"><span id=\"spanHghlt2c55\">\u622a\u81f32022\u5e744\u670830\u65e5\uff0c\u5171119\u4f8b\u65e2\u5f80\u63a5\u53d7\u542b\u94c2\u5316\u7597\u5931\u8d25\u7684\u3001EGFR exon20ins\u7a81\u53d8\u578b\u665a\u671fNSCLC\u60a3\u8005\u7eb3\u5165\u7597\u6548\u5206\u6790\u96c6\u3002\u8212\u6c83\u66ff\u5c3c\u5728\u6837\u672c\u91cf\u663e\u8457\u589e\u52a0\u7684\u60c5\u51b5\u4e0b\u4ecd\u663e\u793a\u5176\u7a33\u5065\u7684\u6297\u80bf\u7624\u7597\u6548\u3002<\/span><\/p>\n<ul type=\"disc\">\n<li><span id=\"spanHghlt8ebe\"><b>84<\/b><b>\u4f8b\u63a5\u53d7\u8212\u6c83\u66ff\u5c3c<\/b><b>RP2D<\/b><b>\u5242\u91cf\uff08<\/b><b>300 mg QD<\/b><b>\uff09<\/b><b>\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08<\/b><b>ORR<\/b><b>\uff09\u9ad8\u8fbe<\/b><b>52.4%<\/b><\/span><\/li>\n<li><span id=\"spanHghlte19f\"><b>\u8212\u6c83\u66ff\u5c3c\u5bf9\u57fa\u7ebf\u4f34\u6709\u8111\u8f6c\u79fb\u7684\u60a3\u8005<\/b><b>ORR<\/b><b>\u8fbe<\/b><b>44%<\/b><b>\uff0c<\/b><b>\u8868\u73b0\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027<\/b><\/span><\/li>\n<li><span id=\"spanHghltd5b3\"><b>\u5206\u6790\u5171\u7eb3\u5165\u7ea6<\/b><b>30<\/b><b>\u79cd<\/b><b>EGFR exon20ins<\/b><b>\u7a81\u53d8\u4e9a\u578b\uff0c\u4e0d\u8bba\u63d2\u5165\u7a81\u53d8\u53d1\u751f\u7684\u4f4d\u7f6e\uff0c\u643a\u5e26<\/b><b>EGFR exon20ins<\/b><b>\u7a81\u53d8\u7684\u60a3\u8005\u5747\u80fd\u4ece\u8212\u6c83\u66ff\u5c3c\u7684\u6cbb\u7597\u4e2d\u83b7\u76ca<\/b><\/span><\/li>\n<\/ul>\n<p><span id=\"spanHghltdd8c\">\u622a\u81f32022\u5e744\u670830\u65e5\uff0c\u5171238\u4f8bEGFR\u6216HER2\u7a81\u53d8\u7684\u665a\u671fNSCLC\u60a3\u8005\u7eb3\u5165\u5b89\u5168\u6027\u5206\u6790\u96c6\u3002<\/span><span id=\"spanHghlt3e79\">\u5b89\u5168\u6027\u6570\u636e\u8f83\u524d\u8fdb\u4e00\u6b65\u6210\u719f\uff0c\u6574\u4f53\u800c\u8a00\uff0c\u8212\u6c83\u66ff\u5c3c\u5b89\u5168\u6027\u826f\u597d\uff0c\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u7c7b\u578b\u4e0e\u4f20\u7edfEGFR TKI\u7c7b\u4f3c\uff0c\u4ee5\u8179\u6cfb\u3001\u76ae\u75b9\u4e3a\u4e3b\uff0c\u4e14\u7edd\u5927\u591a\u6570\u4e3a1-2\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u4e34\u5e8a\u53ef\u7ba1\u7406\u4e14\u53ef\u6062\u590d\u3002<\/span><\/p>\n<p>\u8fea\u54f2\u533b\u836f\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u5f20\u5c0f\u6797\u535a\u58eb\u8868\u793a\uff1a&quot;\u5f88\u9ad8\u5174\u770b\u5230\u8212\u6c83\u66ff\u5c3c\u7684\u7814\u7a76\u6210\u679c\u518d\u6b21\u53d7\u5230\u56fd\u9645\u6743\u5a01\u5927\u4f1a\u7684\u8ba4\u53ef\u3002\u6700\u65b0\u7814\u7a76\u6570\u636e\u5c55\u793a\u4e86\u8212\u6c83\u66ff\u5c3c\u76f8\u8f83\u73b0\u6709\u6cbb\u7597\u836f\u7269\u663e\u8457\u7684\u7597\u6548\u4f18\u52bf\uff0c\u4e5f\u5370\u8bc1\u4e86\u5176\u5728\u56fd\u9645\u4e0a&quot;\u540c\u7c7b\u6700\u4f18&quot;\u7684\u6f5c\u529b\u3002\u671f\u5f85\u8fdb\u4e00\u6b65\u63a8\u52a8\u5404\u9879\u4e34\u5e8a\u7814\u7a76\uff0c\u5c3d\u5feb\u60e0\u53ca\u5168\u7403EGFR exon20ins\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002&quot;<\/p>\n<p>\u5173\u4e8eWCLC<\/p>\n<p>\u7531\u56fd\u9645\u80ba\u764c\u7814\u7a76\u534f\u4f1a \uff08International Association for the Study of Lung Cancer, IASLC\uff09\u4e3b\u529e\u7684\u3001\u76ee\u524d\u4e16\u754c\u4e0a\u6700\u5927\u7684\u81f4\u529b\u4e8e\u80ba\u764c\u548c\u5176\u5b83\u80f8\u90e8\u6076\u6027\u80bf\u7624\u7684\u591a\u5b66\u79d1\u5b66\u672f\u76db\u4f1a\uff0c\u6bcf\u5e74\u4f17\u591a\u91cd\u78c5\u7814\u7a76\u5728\u5927\u4f1a\u5c55\u793a\uff0c\u5e76\u7531\u6b64\u66f4\u65b0\u4e34\u5e8a\u5b9e\u8df5\u3002<\/p>\n<p>\u5173\u4e8eEGFR Exon20ins NSCLC<\/p>\n<p>\u5728\u5168\u7403\u6076\u6027\u80bf\u7624\u5bfc\u81f4\u7684\u6b7b\u4ea1\u4e2d\uff0c\u80ba\u764c\u6392\u540d\u7b2c\u4e00\u3002\u80ba\u764c\u5206\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u548c\u5c0f\u7ec6\u80de\u80ba\u764c\u4e24\u5927\u7c7b\uff0c\u5176\u4e2d\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7ea6\u5360\u80ba\u764c\u768485%\uff0c\u800cEGFR\u7a81\u53d8\u662fNSCLC\u6700\u5e38\u89c1\u7684\u57fa\u56e0\u7a81\u53d8\u7c7b\u578b\u3002\u56fd\u9645\u4e0a\uff0c\u5409\u975e\u66ff\u5c3c\u3001\u5965\u5e0c\u66ff\u5c3c\u7b49\u7b2c\u4e00\u3001\u4e8c\u548c\u4e09\u4ee3EGFR-TKI\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u643a\u5e26EGFR\u654f\u611f\u7a81\u53d8\u3001T790M\u7a81\u53d8\u548c\u90e8\u5206\u7f55\u89c1\u7a81\u53d8\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u4f46EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u7531\u4e8e\u5176\u72ec\u7279\u7684\u86cb\u767d\u7ed3\u6784\uff0c\u73b0\u6709\u76841-3\u4ee3EGFR-TKI\u5bf9\u5176\u6ca1\u6709\u660e\u663e\u6548\u679c\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5316\u7597\u4ecd\u662f\u643a\u5e26EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u7684\u665a\u671fNSCLC\u60a3\u8005\u7684\u6807\u51c6\u6cbb\u7597\u624b\u6bb5\uff0c\u4f46\u7597\u6548\u6709\u9650\u3002\u56e0\u6b64\uff0c\u5728\u7cbe\u51c6\u533b\u7597\u65f6\u4ee3\u4e0b\uff0c\u9488\u5bf9EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u578b\u665a\u671fNSCLC\uff0c\u4e9f\u9700\u5f00\u53d1\u66f4\u9ad8\u6548\u66f4\u5b89\u5168\u7684EGFR TKI\u3002<\/p>\n<p>\u5173\u4e8e\u8212\u6c83\u66ff\u5c3c<\/p>\n<p>\u8212\u6c83\u66ff\u5c3c\u9996\u9009\u9002\u5e94\u75c7\u4e3a\u6cbb\u7597EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u6b63\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6b27\u6d32\u3001\u97e9\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u7b49\u56fd\u5bb6\u548c\u5730\u533a\u5f00\u5c55\u5173\u952e\u6027\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u662f\u7ecf\u72ec\u7acb\u5f71\u50cf\u8bc4\u5ba1\u59d4\u5458\u4f1a\u8bc4\u4f30\u7684ORR\u3002\u622a\u81f32022\u5e744\u670830\u65e5\uff0c\u5168\u7403\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u663e\u793a\uff0c\u8212\u6c83\u66ff\u5c3c\u6700\u4f73ORR\u8fbe\u523052.4%\uff0c\u5bf9\u57fa\u7ebf\u4f34\u6709\u8111\u8f6c\u79fb\u60a3\u8005ORR\u8fbe44%\uff0c\u5e76\u5728Amivantamab\u7597\u6548\u4e0d\u4f73\u6216\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u60a3\u8005\u4e2d\u5747\u663e\u793a\u7597\u6548\u3002\u6b64\u5916\uff0c\u8212\u6c83\u66ff\u5c3c\u5728&nbsp;EGFR\u654f\u611f\u7a81\u53d8\u3001T790M\u7a81\u53d8\u548c&nbsp;HER2 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u4e5f\u89c2\u5bdf\u5230\u521d\u6b65\u7597\u6548\u3002<\/p>\n<p>\u51ed\u501f\u5176\u4f18\u5f02\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u8212\u6c83\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5df2\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3&nbsp;&quot;\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u54c1\u79cd&quot;\u8ba4\u5b9a\u8d44\u683c\u548c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40&nbsp;&quot;\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff08Breakthrough Therapy Designation\uff09&quot;\uff0c\u7814\u7a76\u6210\u679c\u5728\u591a\u4e2a\u56fd\u9645\u5b66\u672f\u4f1a\u8bae\uff082019AACR\u30012021ASCO\u30012021WCLC\uff09\u4e0a\u53d1\u8868\u3002\u8212\u6c83\u66ff\u5c3c\u7684\u8f6c\u5316\u79d1\u5b66\u7814\u7a76\u6210\u679c\uff0c\u4e8e2022\u5e744\u6708\u8363\u767b\u56fd\u9645\u9876\u7ea7\u671f\u520aCancer 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