{"id":74990,"date":"2022-08-04T12:31:00","date_gmt":"2022-08-04T05:31:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022080412310074990"},"modified":"2022-08-04T22:13:47","modified_gmt":"2022-08-04T14:13:47","slug":"nature-medicine%e5%8f%91%e6%96%87%ef%bc%8c%e9%82%a6%e8%80%80%e7%94%9f%e7%89%a9brl-101%e5%9f%ba%e5%9b%a0%e6%b2%bb%e7%96%97%e5%9c%b0%e4%b8%ad%e6%b5%b7%e8%b4%ab%e8%a1%80%e7%97%87%e6%82%a3%e5%84%bf","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022080412310074990","title":{"rendered":"Nature Medicine\u53d1\u6587\uff0c\u90a6\u8000\u751f\u7269BRL-101\u57fa\u56e0\u6cbb\u7597\u5730\u4e2d\u6d77\u8d2b\u8840\u75c7\u60a3\u513f\u8131\u79bb\u8f93\u8840\u4f9d\u8d56\u5df2\u8d85\u8fc72\u5e74"},"content":{"rendered":"

\u4e0a\u6d77<\/span>2022\u5e748\u67084\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — 2022\u5e748\u67084\u65e5\uff0c\u805a\u7126\u4e8e\u57fa\u56e0\u548c\u7ec6\u80de\u6cbb\u7597\u7684\u4e0a\u6d77\u90a6\u8000\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0"\u90a6\u8000\u751f\u7269"\uff09\u5ba3\u5e03\uff0c\u90a6\u8000\u751f\u7269\u548c\u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u533b\u9662\u5408\u4f5c\u7684\u4e16\u754c\u9996\u4f8b<\/b>CRISPR\u57fa\u56e0\u7f16\u8f91\u6cbb\u7597\u03b20\/\u03b20\u578b\u91cd\u5ea6\u5730\u8d2b\u7684\u60a3\u513f\u76ee\u524d\u8131\u79bb\u8f93\u8840\u4f9d\u8d56\u5df2\u8d85\u8fc72\u5e74<\/b>\uff0c\u5f00\u542f\u4e86\u6b63\u5e38\u751f\u6d3b\u548c\u5b66\u4e60\uff0c\u540c\u65f6\u8be5\u9879\u4e34\u5e8a\u8bd5\u9a8c\u6210\u679c\u4eca\u65e5\u53d1\u8868\u5728\u56fd\u9645\u9876\u7ea7\u533b\u5b66\u5b66\u672f\u671f\u520aNature Medicine<\/i>\uff08\u5f71\u54cd\u56e0\u5b50\uff1a<\/b>87.241\uff09<\/b>\uff08Nature Medicine \u53d1\u6587 https:\/\/www.nature.com\/articles\/s41591-022-01906-z<\/a>\uff09<\/span>\u3002<\/p>\n

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\n

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\u90a6\u8000\u751f\u7269\u8463\u4e8b\u957f\u5218\u660e\u8000\u6559\u6388\u8bf4<\/b>\uff0c\u4ece\u4e24\u540d\u60a3\u513f\u63a5\u53d7\u6cbb\u7597\u540e\u7684\u6062\u590d\u7ed3\u679c\u6765\u770b\uff0c\u53ef\u4ee5\u8bf4\u8fd9\u4e00\u7814\u7a76\u4ee3\u8868\u4e86\u56fd\u5185\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5728\u4e34\u5e8a\u8f6c\u5316\u65b9\u9762\u7684\u7a81\u7834\u6027\u6210\u679c\uff0c\u4ece\u57fa\u7840\u5230\u4e34\u5e8a\u8f6c\u5316\u7814\u7a76\u5df2\u5904\u4e8e\u56fd\u9645\u9886\u5148\u6c34\u5e73\u3002\u4e00\u65b9\u9762\uff0c\u91c7\u7528\u57fa\u56e0\u7f16\u8f91\u6cbb\u7597\u65b9\u6848\u5bf9\u6bd4\u4f20\u7edf\u7597\u6cd5\uff0c\u4e0d\u4ec5\u66f4\u4e3a\u9ad8\u6548\u3001\u4fbf\u6377\u548c\u5b89\u5168\uff0c\u4e14\u6210\u672c\u6781\u5927\u964d\u4f4e\uff0c\u6709\u671b\u6210\u4e3a\u66f4\u60e0\u53ca\u5927\u4f17\u7684\u7597\u6cd5\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u57fa\u56e0\u6cbb\u7597\u5730\u8d2b\u7684\u6210\u529f\u6848\u4f8b\uff0c\u771f\u7684\u662f\u8ba9\u5f88\u591a\u5730\u8d2b\u60a3\u513f\u5bb6\u5ead\u770b\u5230\u4e86\u5e0c\u671b\uff0c\u5e76\u4e14\u901a\u8fc7\u65e5\u5e38\u4e0e\u5305\u62ec\u5730\u8d2b\u5728\u5185\u7684\u5927\u91cf\u7f55\u89c1\u75c5\u60a3\u8005\u63a5\u89e6\uff0c\u5bf9\u6b64\u4e5f\u5e0c\u671b\u548c\u547c\u5401\uff0c\u672a\u6765\u4e0d\u53ea\u662f\u805a\u7126\u5730\u8d2b\u9886\u57df\uff0c\u4e5f\u5e0c\u671b\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u80fd\u6cbb\u7597\u66f4\u591a\u7684\u5176\u4ed6\u7f55\u89c1\u6027\u75be\u75c5\u60a3\u8005\u3002<\/p>\n

\u76ee\u524d\uff0c\u90a6\u8000\u751f\u7269\u5229\u7528\u81ea\u4e3b\u5f00\u53d1\u7684\u57fa\u4e8e\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u7684\u9020\u8840\u5e72\u7ec6\u80de\u5e73\u53f0<\/b>(ModiHSC®<\/sup>)<\/b>\u5728\u6cbb\u7597\u03b20\/\u03b20\u578b\u91cd\u5ea6\u5730\u8d2b\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5df2\u53d6\u5f97\u4e86\u826f\u597d\u7684\u6548\u679c\uff0c\u5168\u56fd\u8303\u56f4\u5185\u5df2\u6210\u529f\u5e2e\u52a9\u591a\u4f8b\u03b2\u5730\u8d2b\u60a3\u8005\u8131\u79bb\u8f93\u8840\u4f9d\u8d56\uff08\u6839\u636e\u968f\u8bbf\u60a3\u8005\u6848\u4f8b\uff0c\u65f6\u957f\u5df2\u8d85\u8fc72\u5e74\uff09 <\/span>\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u6b64\u524d\u90a6\u8000\u751f\u7269\u5728\u5730\u8d2b\u9886\u57df\u7684\u7a81\u51fa\u6027\u6210\u679c\u5df2\u9009\u5165\u5230\u7b2c\u4e8c\u7248\u300a\u4e2d\u56fd\u5730\u8d2b\u9632\u6cbb\u84dd\u76ae\u4e66\u300b<\/b>(2020)<\/b>\u7684\u6cbb\u7597\u65b9\u6cd5\u90e8\u5206\uff1b\u5e76\u4e14\u5c31\u57282022\u5e745\u670831\u65e5\uff0c\u90a6\u8000\u751f\u7269\u7684"BRL-101\u81ea\u4f53\u9020\u8840\u5e72\u7956\u7ec6\u80de\u6ce8\u5c04\u6db2"\u7684\u4e34\u5e8a\u7533\u8bf7\u83b7\u5f97\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u54c1\u5ba1\u67e5\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\uff08\u53d7\u7406\u53f7\uff1aCXSL2200236\uff09<\/b>\u3002\u672a\u6765\u9488\u5bf9\u8fd9\u4e00\u9879\u76ee\u7684\u7814\u7a76\u5bf9\u8c61\u5e74\u9f84\u5c06\u8fdb\u4e00\u6b65\u6269\u5927\u523035\u5c81\uff0c\u6709\u671b\u8ba9\u5730\u8d2b\u79fb\u690d\u9886\u57df\u7684"\u8001\u5927\u96be\u7fa4\u4f53" — \u5927\u9f84\u53ca\u914d\u578b\u65e0\u671b\u7684\u60a3\u8005\u53d7\u76ca\u3002<\/p>\n

\u90a6\u8000\u751f\u7269\u4f5c\u4e3a\u4e00\u5bb6\u4ee5"\u4ee5\u57fa\u56e0\u7f16\u8f91\u5f15\u9886\u521b\u65b0\uff0c\u5f00\u53d1\u7a81\u7834\u6027\u7597\u6cd5\uff0c\u9020\u798f\u5168\u4eba\u7c7b<\/b>"\u4e3a\u4f7f\u547d\u7684\u7ec6\u80de\u57fa\u56e0\u836f\u4f01\uff0c\u4e0d\u65ad\u514b\u670d\u884c\u4e1a\u58c1\u5792\uff0c\u8fdb\u884c\u591a\u9776\u70b9\u7684\u6218\u7565\u5e03\u5c40\uff0c\u76ee\u524d\u5728\u57fa\u56e0\u7f16\u8f91\u6cbb\u7597\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u75c7\u3001PD1\u6572\u9664\u975e\u75c5\u6bd2\u5b9a\u70b9\u6574\u5408CAR-T\u3001\u4ee5\u53caUCART\u7b49\u9879\u76ee\u4e2d\u5df2\u7ecf\u53d6\u5f97\u4f18\u5f02\u4e34\u5e8a\u6548\u679c\u3002\u672a\u6765\uff0c\u4ecd\u5c06\u901a\u8fc7\u4e0d\u65ad\u5730\u52a0\u901f\u63a8\u8fdb\u521b\u65b0\u836f\u7269\u7684\u8f6c\u5316\u4e0e\u843d\u5730\uff0c\u4ece\u800c\u9020\u798f\u5305\u62ec\u5730\u4e2d\u6d77\u8d2b\u8840\u5728\u5185\u7684\u5168\u7403\u7f55\u89c1\u9057\u4f20\u75be\u75c5\u53ca\u6076\u6027\u80bf\u7624\u60a3\u8005\uff01<\/p>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u6d772022\u5e748\u67084\u65e5 \/\u7f8e\u901a\u793e\/ — 2022\u5e748\u67084\u65e5\uff0c\u805a\u7126\u4e8e\u57fa\u56e0\u548c\u7ec6\u80de\u6cbb\u7597\u7684\u4e0a\u6d77\u90a6\u8000\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0"\u90a6\u8000\u751f\u7269"\uff09\u5ba3\u5e03\uff0c\u90a6\u8000\u751f\u7269\u548c\u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u533b\u9662\u5408\u4f5c\u7684\u4e16\u754c\u9996\u4f8bCRISPR\u57fa\u56e0\u7f16\u8f91\u6cbb\u7597\u03b20\/\u03b20\u578b\u91cd\u5ea6\u5730\u8d2b\u7684\u60a3\u513f\u76ee\u524d\u8131\u79bb\u8f93\u8840\u4f9d\u8d56\u5df2\u8d85\u8fc72\u5e74\uff0c\u5f00\u542f\u4e86\u6b63\u5e38\u751f\u6d3b\u548c\u5b66\u4e60\uff0c\u540c\u65f6\u8be5\u9879\u4e34\u5e8a\u8bd5\u9a8c\u6210\u679c\u4eca\u65e5\u53d1\u8868\u5728\u56fd\u9645\u9876\u7ea7\u533b\u5b66\u5b66\u672f\u671f\u520aNature Medicine\uff08\u5f71\u54cd\u56e0\u5b50\uff1a87.241\uff09\uff08Nature Medicine \u53d1\u6587 https:\/\/www.nature.com\/articles\/s41591-022-01906-z\uff09\u3002 \u4f5c\u4e3a\u9996\u4e2a\u53d1\u8868\u4e8e\u9876\u7ea7\u5b66\u672f\u671f\u520a\u7684\u57fa\u4e8eCRISPR\u57fa\u56e0\u7f16\u8f91\u6cbb\u7597\u03b20\/\u03b20\u578b\u91cd\u5ea6\u5730\u8d2b\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u6587\u7ae0\u516c\u5e03\u4e86\u8be6\u7ec6\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u66f4\u4e3a\u5168\u9762\u5730\u89e3\u8bfb\u4e86BRL-101\u6cbb\u7597\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7279\u5f81\u3002 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