{"id":73878,"date":"2022-07-27T19:32:00","date_gmt":"2022-07-27T12:32:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022072719320073878"},"modified":"2022-07-27T22:18:15","modified_gmt":"2022-07-27T14:18:15","slug":"%e7%b4%a2%e6%99%ba%e7%94%9f%e7%89%a9%e3%80%81%e5%8b%a4%e6%b5%a9%e5%8c%bb%e8%8d%af%e3%80%81%e7%bb%b4%e7%9c%b8%e7%94%9f%e7%89%a9%e3%80%81domain%e3%80%81amberstone%e3%80%81%e5%ae%89%e6%b5%8e%e8%8d%af","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022072719320073878","title":{"rendered":"\u7d22\u667a\u751f\u7269\u3001\u52e4\u6d69\u533b\u836f\u3001\u7ef4\u7738\u751f\u7269\u3001Domain\u3001Amberstone\u3001\u5b89\u6d4e\u836f\u4e1a\u3001QurAlis\u8fd1\u671f\u53d1\u5c55\u52a8\u6001\u4e00\u89c8"},"content":{"rendered":"

\u4e0a\u6d77<\/span>2022\u5e747\u670827\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u7ef4\u4e9a\u751f\u7269\u6295\u8d44\u5b75\u5316\u751f\u6001\u5708\u8fd1\u671f\u52a8\u6001\u66f4\u65b0\uff1a<\/p>\n

\u7d22\u667a\u751f\u7269\u4e0e\u6e05\u534e\u5927\u5b66\u514d\u75ab\u5b66\u7814\u7a76\u6240\u5408\u4f5c\u63a2\u7d22\u548c\u63a8\u52a8\u81ea\u514d\u9886\u57df\u65b0\u836f\u7814\u53d1\uff1b<\/p>\n

\u52e4\u6d69\u533b\u836fERK1\/2\u6291\u5236\u5242GH55\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u83b7CDE\u53d7\u7406\uff1b<\/p>\n

\u7ef4\u7738\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u9752\u5149\u773c\u53cc\u9776\u70b9\u521b\u65b0\u836fVVN539\u5b8c\u6210\u7f8e\u56fdII\u671f\u4e34\u5e8a\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\uff1b<\/p>\n

Domain Therapeutics\u83b7\u9ed8\u514b\u6570\u767e\u4e07\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u7528\u4e8e\u514d\u75ab\u80bf\u7624\u836f\u7269M1069\u7684\u4e34\u5e8a\u5f00\u53d1\uff1b<\/p>\n

Amberstone Biosciences\u5ba3\u5e03\u6210\u7acb\u79d1\u5b66\u987e\u95ee\u59d4\u5458\u4f1a\uff1b<\/p>\n

\u5b89\u6d4e\u836f\u4e1a\u516c\u5e03\u4e24\u4e2a\u5173\u952e\u9879\u76eeANJ908\u548cANJ900\u7684\u6700\u65b0\u8fdb\u5c55\uff1b<\/p>\n

QurAlis\u5ba3\u5e03\u4efb\u547dAnne C. Whitaker\u4e3a\u8463\u4e8b\u4f1a\u4e3b\u5e2d<\/p>\n

\u7ef4\u4e9a\u751f\u7269\u6295\u8d44\u5b75\u5316\u548c\u4ee5\u670d\u52a1\u6362\u80a1\u6743\uff08EFS\uff09\u4e1a\u52a1\u7684\u6838\u5fc3\u90e8\u95e8 — \u7ef4\u4e9a\u751f\u7269\u521b\u65b0\u4e2d\u5fc3\u81f4\u529b\u4e8e\u6210\u4e3a\u5168\u7403\u521b\u65b0\u751f\u7269\u533b\u836f\u4f01\u4e1a\u5b75\u5316\u53ca\u6210\u957f\u7684\u5f00\u653e\u5f0f\u5408\u4f5c\u5e73\u53f0\u3002<\/p>\n

\u7d22\u667a\u751f\u7269\u4e0e\u6e05\u534e\u5927\u5b66\u514d\u75ab\u5b66\u7814\u7a76\u6240\u5408\u4f5c\u63a2\u7d22\u548c\u63a8\u52a8\u81ea\u514d\u9886\u57df\u65b0\u836f\u7814\u53d1<\/b><\/p>\n

\u8fd1\u671f\uff0c\u7531\u7ef4\u4e9a\u751f\u7269\u53c2\u4e0e\u6295\u8d44\u5b75\u5316\u7684\u7d22\u667a\u751f\u7269\u4e0e\u6e05\u534e\u5927\u5b66\u514d\u75ab\u5b66\u7814\u7a76\u6240\uff08\u7b80\u79f0"\u6e05\u534e\u514d\u75ab\u6240"\uff09\u8fbe\u6210\u5408\u4f5c\uff0c\u53cc\u65b9\u5c06\u5728\u81ea\u8eab\u514d\u75ab\u9886\u57df\u5bf9\u9776\u70b9\u9009\u62e9\u548c\u9a8c\u8bc1\u3001\u53d1\u75c5\u673a\u7406\u7b49\u9886\u57df\u8fdb\u884c\u8bba\u8bc1\u548c\u63a2\u8ba8\uff0c\u52a9\u529b\u7d22\u667a\u751f\u7269\u6253\u9020\u5177\u6709\u5168\u7403\u7ade\u4e89\u529b\u7684\u521b\u65b0\u836f\u7ba1\u7ebf\u3002\u7d22\u667a\u751f\u7269\u4ee5\u672a\u6ee1\u8db3\u7684\u81ea\u514d\u4e34\u5e8a\u9700\u6c42\u4e3a\u51fa\u53d1\u70b9\uff0c\u4f9d\u6258\u56e2\u961f\u5728\u65b0\u836f\u7814\u53d1\u7684\u4e30\u5bcc\u7ecf\u9a8c\uff0c\u7ed3\u5408\u7d22\u667a\u751f\u7269\u5b8c\u6574\u7684AI\u65b0\u836f\u7814\u53d1\u5e73\u53f0AIxMol™\uff0c\u4e3a\u81ea\u514d\u75be\u75c5\u60a3\u8005\u5e26\u6765\u4e2a\u6027\u5316\u7cbe\u51c6\u6cbb\u7597\u548c\u6df1\u5ea6\u75be\u75c5\u7f13\u89e3\u7684\u89e3\u51b3\u65b9\u6848\u3002\u53cc\u65b9\u4e8e7\u670819\u65e5\u5728\u5317\u4eac\u53ec\u5f00\u4e86\u9996\u6b21\u7ba1\u7ebf\u6218\u7565\u7814\u8ba8\u4f1a\u8bae\u3002\u672c\u6b21\u4f1a\u8bae\u7531\u6e05\u534e\u5927\u5b66\u514d\u75ab\u5b66\u7814\u7a76\u6240\u80e1\u5c0f\u7389\u3001\u5218\u5fd7\u534e\u3001\u66fe\u6587\u6587\u4e09\u4f4d\u8001\u5e08\u4e0e\u7d22\u667a\u751f\u7269\u56e2\u961f\u6210\u5458\u5171\u540c\u53c2\u4e0e\u3002<\/p>\n

\u52e4\u6d69\u533b\u836fERK1\/2<\/b>\u6291\u5236\u5242GH55<\/b>\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u83b7CDE<\/b>\u53d7\u7406<\/b><\/p>\n

2022\u5e747\u670812\u65e5\uff0c\u7531\u7ef4\u4e9a\u751f\u7269\u53c2\u4e0e\u6295\u8d44\u5b75\u5316\u7684\uff0c\u81f4\u529b\u4e8e\u5229\u7528\u7ec4\u5408\u6280\u672f\u5e73\u53f0\u5f00\u53d1\u5168\u7403\u65b0\u4e00\u4ee3\u6297\u80bf\u7624\u5c0f\u5206\u5b50\u836f\u7269\u7684\u7814\u53d1\u4f01\u4e1a — \u52e4\u6d69\u533b\u836f\u5ba3\u5e03\uff0c\u6839\u636e\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u6700\u65b0\u516c\u793a\uff0c\u8fd1\u65e5\uff0c\u7531\u52e4\u6d69\u533b\u836f\u7533\u62a5\u76841\u7c7b\u65b0\u836fGH55\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u5df2\u7ecf\u83b7\u5f97\u53d7\u7406\u3002\u4e0e\u6b64\u540c\u65f6\uff0cGH55\u7684\u7f8e\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u4e5f\u5728\u79ef\u6781\u7b79\u5907\u4e2d\u3002<\/p>\n

GH55\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u8fdb\u4e00\u6b65\u5b8c\u5584\u4e86\u52e4\u6d69\u533b\u836f1.0\u7ba1\u7ebf\u5728RAS\/MAPK\u4fe1\u53f7\u901a\u8def\u4e0a\u7684\u6218\u7565\u5e03\u5c40\u3002GH55\u662f\u4e00\u4e2a\u53cc\u673a\u5236ERK1\/2\u6291\u5236\u5242\uff0c\u5b83\u5728\u6291\u5236ERK1\/2\u6fc0\u9176\u6d3b\u6027\u7684\u540c\u65f6\uff0c\u80fd\u591f\u6291\u5236MEK\u5bf9\u4e8eERK1\/2\u7684\u6fc0\u6d3b\uff0c\u9632\u6b62\u7531\u4e8e\u8d1f\u53cd\u9988\u8c03\u8282\u9020\u6210\u7684\u8010\u836f\u3002<\/p>\n

\u7ef4\u7738\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u9752\u5149\u773c\u53cc\u9776\u70b9\u521b\u65b0\u836fVVN539<\/b>\u5b8c\u6210\u7f8e\u56fdII<\/b>\u671f\u4e34\u5e8a\u9996\u4f8b\u60a3\u8005\u5165\u7ec4<\/b><\/p>\n

7\u67088\u65e5\uff0c\u7ef4\u7738\u751f\u7269\u79d1\u6280\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8\uff08"\u7ef4\u7738\u751f\u7269"\uff09\u662f\u7531\u7ef4\u4e9a\u751f\u7269\u53c2\u4e0e\u6295\u8d44\u5b75\u5316\u7684\u3001\u4e00\u5bb6\u805a\u7126\u5dee\u5f02\u5316\u548c\u5168\u7403\u65b0\u5f00\u53d1\u7684\u773c\u79d1\u521b\u65b0\u836f\u516c\u53f8\uff0c\u5ba3\u5e03\u5176\u81ea\u4e3b\u7814\u53d1\u7684\u53cc\u9776\u70b9\u836f\u7269VVN539\uff0c\u9488\u5bf9\u5f00\u89d2\u578b\u9752\u5149\u773c\u60a3\u8005\u7684\u7f8e\u56fdII\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u5728\u7f8e\u56fd\u7ebd\u7ea6\u5dde\u7684Rochester Ophthalmological Group\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\u3002\u8fd9\u4e5f\u6807\u5fd7\u7740\u56fd\u5185\u9996\u4e2a<\/span>\u9752\u5149\u773c\u81ea\u4e3b\u521b\u65b0\u836f\u7684\u5f00\u53d1\uff0c\u8fdb\u5165\u4e86\u5feb\u901f\u63a8\u8fdb\u9636\u6bb5\u3002<\/p>\n

\u672c\u4e34\u5e8a\u7814\u7a76\u662f\u4e00\u9879\u8bc4\u4f30VVN539\u6ef4\u773c\u6db2\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u6eb6\u5a92\u5bf9\u7167\u3001\u5242\u6548\u63a2\u7d22\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002VVN539\u662f\u7ef4\u7738\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u5e76\u62e5\u6709\u5168\u7403\u77e5\u8bc6\u4ea7\u6743\u7684\u4e00\u6b3e\u6ef4\u773c\u7528\u836f\uff0c\u4f5c\u4e3a\u65b0\u4e00\u4ee3\u3001\u5177\u6709\u53cc\u9776\u70b9\u673a\u5236\u7684\u836f\u7269\uff0c\u76f4\u63a5\u4f5c\u7528\u4e8e\u773c\u90e8\u5c0f\u6881\u7f51\uff0c\u589e\u52a0\u623f\u6c34\u5916\u6d41\uff0c\u4ee5\u8fbe\u5230\u7406\u60f3\u7684\u964d\u4f4e\u773c\u538b\u7684\u6548\u679c\u3002<\/p>\n

Domain Therapeutics<\/b>\u83b7\u9ed8\u514b\u6570\u767e\u4e07\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u7528\u4e8e\u514d\u75ab\u80bf\u7624\u836f\u7269M1069<\/b>\u7684\u4e34\u5e8a\u5f00\u53d1<\/b><\/p>\n

6\u670828\u65e5\uff0cDomain Therapeutics\uff0c\u4e00\u5bb6\u7531\u7ef4\u4e9a\u751f\u7269\u53c2\u4e0e\u6295\u8d44\u5b75\u5316\u7684\uff0c\u4e13\u6ce8\u4e8e\u7814\u7a76\u548c\u5f00\u53d1\u514d\u75ab\u80bf\u7624\u5b66\u9886\u57df\u9776\u5411G\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff08GPCR\uff09\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5ba3\u5e03\u6536\u5230\u6765\u81ea\u9ed8\u514b\u5355\u7b14\u6570\u767e\u4e07\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002\u6839\u636e2017\u5e74Domain Therapeutics\u4e0e\u9ed8\u514b\u516c\u53f8\u7b7e\u7f72\u7684\u6536\u5165\u5408\u4f5c\u548c\u8bb8\u53ef\u5408\u4f5c\u534f\u8bae\uff08\u6b64\u534f\u8bae\u672a\u62ab\u9732\uff09\uff0c\u6b64\u6b21\u4ed8\u6b3e\u5c5e\u4e8e\u53cc\u65b9\u7ea6\u5b9a\u7684\u91d1\u989d\u4e3a 2.4 \u4ebf\u6b27\u5143\uff082.61 \u4ebf\u7f8e\u5143\uff09\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002<\/p>\n

M1069\u662f\u7531\u53cc\u65b9\u516c\u53f8\u5171\u540c\u5f00\u53d1\u7684\u4e00\u79cd\u53ef\u53e3\u670d\u7684\u817a\u82f7\u53d7\u4f53\u5c0f\u5206\u5b50\u62ee\u6297\u5242\u3002\u6b64\u6b21\u9ad8\u6548\u4e14\u6210\u529f\u7684\u5408\u4f5c\uff0c\u57fa\u4e8eDomain\u5728GPCR\u836f\u7269\u5316\u5b66\u3001\u836f\u7406\u5b66\u548c\u836f\u7269\u65b9\u9762\u7684\u4e13\u4e1a\u77e5\u8bc6\uff0c\u4ece\u800c\u4f7f\u5f97M1069\u88ab\u6210\u529f\u7eb3\u5165\u9ed8\u514b\u7684\u80bf\u7624\u7ba1\u9053\u3002M1069\u662fDomain\u73b0\u6709\u7ba1\u9053\u4e2d\u7b2c\u4e00\u4e2a\u5230\u8fbe\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u7684\u514d\u75ab\u80bf\u7624\u5b66\u9886\u57df\u5019\u9009\u836f\u7269\u3002<\/p>\n

Amberstone Biosciences<\/b>\u5ba3\u5e03\u6210\u7acb\u79d1\u5b66\u987e\u95ee\u59d4\u5458\u4f1a<\/b><\/p>\n

\u7531\u7ef4\u4e9a\u751f\u7269\u53c2\u4e0e\u6295\u8d44\u5b75\u5316\u7684Amberstone Biosciences\uff0c\u662f\u4e00\u5bb6\u65b0\u5174\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u65b0\u4e00\u4ee3\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u3002\u8fd1\u65e5\uff0c\u5176\u5ba3\u5e03\u6210\u7acb\u79d1\u5b66\u987e\u95ee\u59d4\u5458\u4f1a\uff0c\u7531\u836f\u7269\u9012\u9001\u3001\u80bf\u7624\u5b66\u3001\u514d\u75ab\u5b66\u548c\u836f\u7269\u5f00\u53d1\u9886\u57df\u7684\u9876\u7ea7\u79d1\u5b66\u5bb6\u7ec4\u6210\u3002\u79d1\u5b66\u987e\u95ee\u59d4\u5458\u4f1a\u5c06\u4e0eAmberstone\u5bc6\u5207\u5408\u4f5c\uff0c\u5171\u540c\u63a8\u8fdb\u516c\u53f8\u57fa\u4e8e\u80bf\u7624\u5fae\u73af\u5883\u7279\u5f02\u6027\u6fc0\u6d3b\u7597\u6cd5(T-MATE) \u7684\u4ea7\u54c1\u7ba1\u7ebf\u3002Amberstone\u79d1\u5b66\u987e\u95ee\u59d4\u5458\u4f1a\u6210\u5458\u5305\u62ec\u9ebb\u7701\u7406\u5de5\u5b66\u9662\uff08Massachusetts Institute of Technology\uff09\u6559\u6388\uff0cModerna\u7684\u8054\u5408\u521b\u59cb\u4eba\u517c\u8463\u4e8b\u4f1a\u8463\u4e8b\uff0c\u53ca\u88ab\u4e1a\u5185\u8a89\u4e3a"\u7ec4\u7ec7\u5de5\u7a0b\u548c\u836f\u7269\u9012\u9001\u4e4b\u7236"\u7684Robert Langer\u535a\u58eb\u3001\u5b89\u8fdb\uff08Amgen\uff09\u7814\u53d1\u526f\u603b\u88c1Philip Tagari\u7b49\u77e5\u540d<\/span>\u79d1\u5b66\u5bb6\u3002<\/p>\n

\u5b89\u6d4e\u836f\u4e1a\u516c\u5e03\u4e24\u4e2a\u5173\u952e\u9879\u76eeANJ908<\/b>\u548cANJ900<\/b>\u7684\u6700\u65b0\u8fdb\u5c55<\/b><\/p>\n

\u8fd1\u671f\uff0c\u7531\u7ef4\u4e9a\u751f\u7269\u53c2\u4e0e\u6295\u8d44\u5b75\u5316\u7684\u5b89\u6d4e\u836f\u4e1a\u5728\u4e24\u4e2a\u91cd\u8981\u79d1\u5b66\u5927\u4f1a — \u6d88\u5316\u75be\u75c5\u5468\uff08DDW\uff09\u548c\u7f8e\u56fd\u7cd6\u5c3f\u75c5\u534f\u4f1a\uff08ADA\uff09\u7b2c82\u5c4a\u79d1\u5b66\u4f1a\u8bae\u4e0a\u5206\u522b\u5206\u4eab\u4e86\u5173\u952e\u9879\u76eeANJ908\u548cANJ900\u7684\u6700\u65b0\u8fdb\u5c55\uff1a<\/p>\n

-\u5b89\u6d4e\u5df2\u5b8c\u6210\u6cbb\u7597\u6162\u6027\u4fbf\u79d8\u7684ANJ908\uff08pradigastat\uff092\u671f\u7814\u7a76\u7684\u60a3\u8005\u5165\u7ec4\uff1b<\/p>\n

-\u76ee\u524d\u6b63\u5728\u62db\u52df\u6b63\u5e38\u80be\u529f\u80fd\u3001\u6216\u60a3\u6709\u8f7b\u4e2d\u5ea6\u6162\u6027\u80be\u75c5\uff08CKD 1-3B\u671f\uff09\u76842\u578b\u7cd6\u5c3f\u75c5\uff08T2D\uff09\u60a3\u8005\uff0c\u5f00\u5c55 ANJ900\uff08\u4e8c\u7532\u53cc\u80cd\u5ef6\u8fdf\u91ca\u653e\u65b0\u5242\u578b\uff09\u7684\u5168\u74033\u671f\u7814\u7a76\uff1b\u9884\u8ba1\u57282022\u5e74\u7b2c\u56db\u5b63\u5ea6\u5c06ANJ900\u5168\u7403\u8ba1\u5212\u6269\u5c55\u81f3\u5e76\u53d1CKD3B\/4\u7684T2D\u60a3\u8005\uff0c\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u548c\u4e16\u754c\u5176\u4ed6\u5730\u533a\u5f00\u5c55\u7814\u7a76\u3002<\/p>\n

QurAlis<\/b>\u5ba3\u5e03\u4efb\u547dAnne C. Whitaker<\/b>\u4e3a\u8463\u4e8b\u4f1a\u4e3b\u5e2d<\/b><\/p>\n

2022\u5e746\u670821\u65e5\uff0cQurAlis Corporation\uff0c\u4e00\u5bb6\u7531\u7ef4\u4e9a\u751f\u7269\u53c2\u4e0e\u6295\u8d44\u5b75\u5316\u7684\uff0c\u4e13\u6ce8\u4e8e\u7cbe\u786e\u6cbb\u7597\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u548c\u5176\u4ed6\u795e\u7ecf\u75be\u75c5\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u5ba3\u5e03\u4efb\u547dAnne Clem Whitaker\u4e3a\u8463\u4e8b\u4f1a\u4e3b\u5e2d\u3002\u4f5c\u4e3a\u4e1a\u5185\u8d44\u6df1\u4eba\u58eb\uff0cWhitaker\u5973\u58eb\u66fe\u5728\u591a\u5bb6\u5927\u578b\u5236\u836f\u4f01\u4e1a\u53ca\u751f\u7269\u6280\u672f\u516c\u53f8\u62c5\u4efb\u8981\u804c\uff0c\u62e5\u6709\u4e30\u5bcc\u7684\u5546\u4e1a\u5316\u7ecf\u9a8c\u548c\u51fa\u8272\u7684\u9886\u5bfc\u80fd\u529b\u3002\u5979\u7684\u52a0\u5165\uff0c\u5c06\u8fdb\u4e00\u6b65\u63a8\u52a8\u516c\u53f8ALS\u548c\u5176\u4ed6\u4e25\u91cd\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u7814\u53d1\u3002<\/p>\n

\u5173\u4e8e\u7d22\u667a\u751f\u7269<\/b><\/p>\n

\u7d22\u667a\u751f\u7269\u662f\u4e00\u5bb6\u4ee5\u9700\u6c42\u9a71\u52a8\u3001\u4eba\u5de5\u667a\u80fd\u65b0\u836f\u7814\u53d1\u6280\u672f\u4e3a\u57fa\u7840\u7684\u521b\u65b0\u533b\u836f\u516c\u53f8\u3002\u6211\u4eec\u4e13\u6ce8\u4e8e\u7814\u53d1\u6cbb\u7597\u514d\u75ab\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\uff0c\u540c\u65f6\u6839\u636e\u7814\u53d1\u7684\u9700\u6c42\uff0c\u901a\u8fc7\u5f15\u8fdb\u3001\u5408\u4f5c\u548c\u6280\u672f\u521b\u65b0\uff0c\u6253\u9020\u2014\u4e2a\u7aef\u5230\u7aef\u7684AI\u65b0\u836f\u784f\u53d1\u65b0\u8303\u5f0f\uff0c\u5e2e\u52a9\u5b9e\u73b0\u9ad8\u6548\u548c\u9ad8\u7cbe\u5ea6\u7684\u5dee\u5f02\u5316\u65b0\u836f\u521b\u65b0\u3002\u6253\u9020\u2014\u4e2a\u4ee5\u4eba\u5de5\u667a\u80fd\u53ca\u6570\u636e\u4e3a\u57fa\u7840\u7684\u3001\u57fa\u4e8e\u7ed3\u6784\u7684\u9ad8\u6548\u65b0\u836f\u784f\u53d1\u65b0\u8303\u5f0f\u3002<\/p>\n

\u5173\u4e8e\u52e4\u6d69\u533b\u836f<\/b><\/p>\n

\u52e4\u6d69\u533b\u836f\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u5168\u7403\u9886\u5148\u7684\u5c0f\u5206\u5b50\u6297\u80bf\u7624\u65b0\u836f\u5f00\u53d1\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u516c\u53f8\u7ba1\u7406\u5c42\u62e5\u6709\u591a\u5e74\u4f01\u4e1a\u7ba1\u7406\u3001\u65b0\u836f\u7814\u53d1\u3001\u4e34\u5e8a\u533b\u5b66\u7814\u7a76\u7ecf\u9a8c\uff0c\u81f4\u529b\u4e8e\u7a81\u7834"\u96be\u4ee5\u6210\u836f"\u9776\u70b9\uff0c\u805a\u7126\u539f\u59cb\u521b\u65b0\u3002\u52e4\u6d69\u533b\u836f\u7740\u529b\u6253\u9020\u72ec\u5177\u7279\u8272\u7684\u521b\u65b0\u836f\u7269\u7814\u53d1\u4f53\u7cfb\uff0c\u5efa\u7acb\u4e86\u57fa\u4e8e\u7ed3\u6784\u751f\u7269\u5b66\u7684\u6784\u6548\u5173\u7cfb\u7814\u7a76\u5e73\u53f0\uff0c\u57fa\u4e8e\u9776\u70b9\u7814\u7a76\u7684\u65e9\u671f\u836f\u7269\u7b5b\u9009\u5e73\u53f0\u4ee5\u53ca\u6db5\u76d6\u836f\u6548\u3001\u4ee3\u8c22\u548c\u5b89\u5168\u6027\u7814\u7a76\u7684\u4e34\u5e8a\u524d\u8bc4\u4ef7\u5e73\u53f0\uff0c\u5f62\u6210\u4e86\u4ee5\u9776\u5411\u6297\u80bf\u7624\u54c1\u79cd\u4e3a\u6838\u5fc3\u7684\u4ea7\u54c1\u7ba1\u7ebf\u3002<\/p>\n

\u5173\u4e8e\u7ef4\u7738\u751f\u7269<\/b><\/p>\n

\u7ef4\u7738\u751f\u7269\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u773c\u79d1\u6cbb\u7597\u9886\u57df\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u62e5\u6709\u56fd\u9645\u4e00\u6d41\u7684\u773c\u79d1\u521b\u65b0\u836f\u7814\u53d1\u56e2\u961f\u548c\u6280\u672f\u5e73\u53f0\uff0c\u4f9d\u6258\u81ea\u4e3b\u7814\u53d1\u5df2\u7ecf\u5efa\u7acb\u8d77\u5177\u6709\u5168\u7403\u7ade\u4e89\u529b\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ecFirst-in-Class\u548cBest-in-Class\u4ea7\u54c1\u3002\u9664VVN001\u3001VVN539\u6b63\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u9879\u76ee\u5916\uff0c\u7528\u4e8e\u6cbb\u7597\u975e\u611f\u67d3\u6027\u8461\u8404\u819c\u708e\u7684VVN461\u7684\u4e2d\u56fdI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u5373\u5c06\u5c55\u5f00\u3002\u66f4\u591a\u4fe1\u606f\u8bf7\u8bbf\u95ee\uff1awww.vivavisionbio.com<\/a><\/p>\n

\u5173\u4e8eDomain Therapeutics<\/b><\/p>\n

Domain Therapeutics\u662f\u4e00\u5bb6\u5728\u6cd5\u56fd\u548c\u52a0\u62ff\u5927\u4e24\u5730\u7ecf\u8425\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u548c\u5f00\u53d1\u9776\u5411G\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff08GPCR\uff09\u7684\u521b\u65b0\u5019\u9009\u836f\u7269\u3002GPCR\u662f\u76ee\u524d\u6700\u91cd\u8981\u7684\u836f\u7269\u9776\u70b9\u79cd\u7c7b\u4e4b\u4e00\u3002\u516c\u53f8\u4e13\u6ce8\u4e8e\u5f00\u53d1\u5177\u6709\u9ad8\u4ef7\u503c\u7684\u5019\u9009\u836f\u7269\uff0c\u4ee5\u89e3\u51b3\u514d\u75ab\u80bf\u7624\u5b66\u4e2dGPCR\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\u3002\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\uff1awww.domaintherapeutics.com<\/a><\/p>\n

\u5173\u4e8e Amberstone Biosciences<\/b><\/p>\n

Amberstone Biosciences\u6210\u7acb\u4e8e2018\u5e74\uff0c\u662f\u4e00\u5bb6\u65b0\u5174\u7684\u751f\u7269\u6cbb\u7597\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u65b0\u578b\u7684\u80bf\u7624\u5fae\u73af\u5883\u6fc0\u6d3b\u514d\u75ab\u7597\u6cd5\u6765\u6cbb\u7597\u5b9e\u4f53\u764c\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.amberstonebio.com<\/a><\/p>\n

\u5173\u4e8e\u5b89\u6d4e\u836f\u4e1a<\/b><\/p>\n

\u5b89\u6d4e\u836f\u4e1a\u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u4e3a\u60a3\u8005\u63d0\u4f9b\u521b\u65b0\u7597\u6cd5\u4ee5\u663e\u8457\u63d0\u5347\u751f\u547d\u8d28\u91cf\u3002\u5b89\u6d4e\u7684\u5546\u4e1a\u6a21\u5f0f\u4ee5\u4ea7\u54c1\u7ba1\u7ebf\u4e3a\u4e2d\u5fc3\uff0c\u91c7\u7528"hub-and-spoke"\u6a21\u5f0f\uff0c\u5145\u5206\u53d1\u6325\u4e34\u5e8a\u5f00\u53d1\u7684\u6838\u5fc3\u80fd\u529b\uff0c\u5feb\u901f\u7075\u6d3b\u5730\u521b\u9020\u4e34\u5e8a\u4ef7\u503c\u3002\u5b89\u6d4e\u6b63\u5728\u8fdb\u884c\u540e\u671f\u4e34\u5e8a\u5f00\u53d1\u7684\u521b\u65b0\u836f\u7269\u5305\u62ec\uff1a\u76d0\u9178\u4e8c\u7532\u53cc\u80cd\u8fdf\u91ca\u7247\uff08ANJ900\u2013 \u5168\u7403\u4e34\u5e8a3\u671f\uff09\uff0c\u7528\u4ee5\u6709\u6548\u7ba1\u7406\u5408\u5e76\u4e2d\u91cd\u5ea6\u6162\u6027\u80be\u75c5\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8840\u7cd6\u6c34\u5e73\uff1b\u4ee5\u53capradigastat\uff08ANJ908 \u2013 \u5168\u7403\u4e34\u5e8a2\u671f\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u4fbf\u79d8\u3002\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.anjipharma.com<\/a><\/p>\n

\u5173\u4e8eQurAlis<\/b><\/p>\n

QurAlis\u5f00\u62d3\u6027\u5730\u7814\u53d1\u6cbb\u7597\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u548c\u5176\u4ed6\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u65b0\u4e00\u4ee3\u7cbe\u51c6\u836f\u7269\u3002\u6e90\u4e8e\u5bf9\u81f4\u75c5\u57fa\u56e0\u6df1\u5165\u7684\u7814\u7a76\uff0cQurAlis\u4f9d\u6258\u4e8e\u751f\u7269\u6807\u8bb0\u7269\u53d1\u73b0\u548c\u72ec\u6709\u7684\u7814\u53d1\u5e73\u53f0\uff0c\u5bf9\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u8fdb\u884c\u7cbe\u51c6\u6cbb\u7597\u3002\u516c\u53f8\u7531\u56fd\u9645\u4e00\u6d41\u7684\u3001\u6765\u81ea\u4e8e\u54c8\u4f5b\u5927\u5b66\u548c\u54c8\u4f5b\u533b\u5b66\u9662\u7684\u795e\u7ecf\u751f\u7269\u5b66\u4e13\u5bb6\u521b\u7acb\uff0c\u76ee\u524d\u5df2\u642d\u5efa\u5305\u62ec\u6838\u9178\u548c\u5c0f\u5206\u5b50\u591a\u4e2a\u9879\u76ee\u7684\u7814\u53d1\u7ba1\u7ebf\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u89e3\u51b3ALS\u4e2d\u4e3b\u8981\u4e9a\u578b\u7684\u6cbb\u7597\u65b0\u65b9\u6cd5\u3002\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.quralis.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u6d772022\u5e747\u670827\u65e5 \/\u7f8e\u901a\u793e\/ — \u7ef4\u4e9a\u751f\u7269\u6295\u8d44\u5b75\u5316\u751f\u6001\u5708\u8fd1\u671f\u52a8\u6001\u66f4\u65b0\uff1a \u7d22\u667a\u751f\u7269\u4e0e\u6e05\u534e\u5927\u5b66\u514d\u75ab\u5b66\u7814\u7a76\u6240\u5408\u4f5c\u63a2\u7d22\u548c\u63a8\u52a8\u81ea\u514d\u9886\u57df\u65b0\u836f\u7814\u53d1\uff1b \u52e4\u6d69\u533b\u836fERK1\/2\u6291\u5236\u5242GH55\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u83b7CDE\u53d7\u7406\uff1b \u7ef4\u7738\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u9752\u5149\u773c\u53cc\u9776\u70b9\u521b\u65b0\u836fVVN539\u5b8c\u6210\u7f8e\u56fdII\u671f\u4e34\u5e8a\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\uff1b Domain Therapeutics\u83b7\u9ed8\u514b\u6570\u767e\u4e07\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u7528\u4e8e\u514d\u75ab\u80bf\u7624\u836f\u7269M1069\u7684\u4e34\u5e8a\u5f00\u53d1\uff1b Amberstone Biosciences\u5ba3\u5e03\u6210\u7acb\u79d1\u5b66\u987e\u95ee\u59d4\u5458\u4f1a\uff1b \u5b89\u6d4e\u836f\u4e1a\u516c\u5e03\u4e24\u4e2a\u5173\u952e\u9879\u76eeANJ908\u548cANJ900\u7684\u6700\u65b0\u8fdb\u5c55\uff1b QurAlis\u5ba3\u5e03\u4efb\u547dAnne C. Whitaker\u4e3a\u8463\u4e8b\u4f1a\u4e3b\u5e2d \u7ef4\u4e9a\u751f\u7269\u6295\u8d44\u5b75\u5316\u548c\u4ee5\u670d\u52a1\u6362\u80a1\u6743\uff08EFS\uff09\u4e1a\u52a1\u7684\u6838\u5fc3\u90e8\u95e8 — \u7ef4\u4e9a\u751f\u7269\u521b\u65b0\u4e2d\u5fc3\u81f4\u529b\u4e8e\u6210\u4e3a\u5168\u7403\u521b\u65b0\u751f\u7269\u533b\u836f\u4f01\u4e1a\u5b75\u5316\u53ca\u6210\u957f\u7684\u5f00\u653e\u5f0f\u5408\u4f5c\u5e73\u53f0\u3002 \u7d22\u667a\u751f\u7269\u4e0e\u6e05\u534e\u5927\u5b66\u514d\u75ab\u5b66\u7814\u7a76\u6240\u5408\u4f5c\u63a2\u7d22\u548c\u63a8\u52a8\u81ea\u514d\u9886\u57df\u65b0\u836f\u7814\u53d1 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Technology\uff09\u6559\u6388\uff0cModerna\u7684\u8054\u5408\u521b\u59cb\u4eba\u517c\u8463\u4e8b\u4f1a\u8463\u4e8b\uff0c\u53ca\u88ab\u4e1a\u5185\u8a89\u4e3a"\u7ec4\u7ec7\u5de5\u7a0b\u548c\u836f\u7269\u9012\u9001\u4e4b\u7236"\u7684Robert Langer\u535a\u58eb\u3001\u5b89\u8fdb\uff08Amgen\uff09\u7814\u53d1\u526f\u603b\u88c1Philip Tagari\u7b49\u77e5\u540d\u79d1\u5b66\u5bb6\u3002 \u5b89\u6d4e\u836f\u4e1a\u516c\u5e03\u4e24\u4e2a\u5173\u952e\u9879\u76eeANJ908\u548cANJ900\u7684\u6700\u65b0\u8fdb\u5c55 \u8fd1\u671f\uff0c\u7531\u7ef4\u4e9a\u751f\u7269\u53c2\u4e0e\u6295\u8d44\u5b75\u5316\u7684\u5b89\u6d4e\u836f\u4e1a\u5728\u4e24\u4e2a\u91cd\u8981\u79d1\u5b66\u5927\u4f1a — \u6d88\u5316\u75be\u75c5\u5468\uff08DDW\uff09\u548c\u7f8e\u56fd\u7cd6\u5c3f\u75c5\u534f\u4f1a\uff08ADA\uff09\u7b2c82\u5c4a\u79d1\u5b66\u4f1a\u8bae\u4e0a\u5206\u522b\u5206\u4eab\u4e86\u5173\u952e\u9879\u76eeANJ908\u548cANJ900\u7684\u6700\u65b0\u8fdb\u5c55\uff1a 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