{"id":72967,"date":"2022-07-19T22:51:00","date_gmt":"2022-07-19T15:51:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022071922510072967"},"modified":"2022-07-20T22:09:49","modified_gmt":"2022-07-20T14:09:49","slug":"%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%af%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%85%b1%e5%90%8c%e5%ae%a3%e5%b8%83%e8%80%90%e7%ab%8b%e5%85%8b%e6%b2%bb%e7%96%97%e8%80%90%e8%8d%afcml%e4%b8%8a","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022071922510072967","title":{"rendered":"\u4e9a\u76db\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5171\u540c\u5ba3\u5e03\u8010\u7acb\u514b\u00ae\u6cbb\u7597\u8010\u836fCML\u4e0a\u5e02\u7533\u8bf7\u83b7CDE\u53d7\u7406\uff0c\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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\n<\/p><\/div>\n

2021\u5e7411\u6708\uff0cNMPA\u901a\u8fc7\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u7a0b\u5e8f\u9644\u6761\u4ef6\u6279\u51c6\u8010\u7acb\u514b®<\/sup>\u4e0a\u5e02\u7533\u8bf7\uff0c\u7528\u4e8e\u6cbb\u7597\u4efb\u4f55TKI\u8010\u836f\uff0c\u5e76\u91c7\u7528\u7ecf\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u8bca\u65ad\u4e3a\u4f34\u6709T315I\u7a81\u53d8\u7684CML-CP\u6216CML-AP\u7684\u6210\u4eba\u60a3\u8005\u3002\u5176\u4e0a\u5e02\u6253\u7834\u4e86\u4e2d\u56fd\u643aT315I\u7a81\u53d8\u8010\u836fCML\u60a3\u8005\u957f\u671f\u65e0\u836f\u53ef\u533b\u7684\u56f0\u5883\uff0c\u586b\u8865\u4e86\u4e34\u5e8a\u7a7a\u767d\u3002<\/p>\n

\u6b64\u6b21\u53d7\u7406\u53ca\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u662f\u57fa\u4e8e\u4e00\u9879\u5f00\u653e\u3001\u968f\u673a\u5bf9\u7167\u7684\u786e\u8bc1\u6027\u5173\u952e\u6ce8\u518cII\u671f\u7814\u7a76\uff08HQP1351CC203\u7814\u7a76\uff09\uff0c2021\u5e743\u6708CDE\u5df2\u57fa\u4e8e\u6b64\u9879\u7814\u7a76\u5c06\u8010\u7acb\u514b®<\/sup>\u7eb3\u5165\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\u3002\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u8010\u7acb\u514b®<\/sup>\u5728\u4e00\u4ee3\u548c\u4e8c\u4ee3TKIs\u8010\u836f\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u3001\u5b89\u5168\u6027\uff0c\u5171\u5165\u7ec4144\u4f8b\u53d7\u8bd5\u8005\uff0c\u968f\u673a\u5206\u914d\u5230\u8010\u7acb\u514b®<\/sup>\u6cbb\u7597\u7ec4\u548c\u73b0\u6709\u6700\u4f73\u6cbb\u7597\uff08Best Available Treatment, BAT\uff09\u5bf9\u7167\u7ec4\uff0c\u4ee5\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u4e3a\u4e3b\u8981\u7ec8\u70b9\u6307\u6807\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a\u8010\u7acb\u514b®<\/sup>\u76f8\u6bd4\u5bf9\u7167\u7ec4\u663e\u8457\u5ef6\u957f\u4e86EFS\uff0c\u8fbe\u5230\u4e86\u9884\u8bbe\u7684\u4f18\u6548\u6807\u51c6\u3002\u5177\u4f53\u7814\u7a76\u6570\u636e\u5c06\u5728\u672a\u6765\u76f8\u5173\u5b66\u672f\u4f1a\u8bae\u4e0a\u8fdb\u884c\u62ab\u9732\u3002<\/p>\n

CML\u662f\u4e00\u79cd\u4e0e\u767d\u7ec6\u80de\u6709\u5173\u7684\u6076\u6027\u80bf\u7624\u3002\u968f\u7740\u9776\u5411BCR-ABL\u7684TKI\u836f\u7269\u4e0a\u5e02\uff0c\u9488\u5bf9CML\u7684\u6cbb\u7597\u65b9\u5f0f\u5f97\u4ee5\u9769\u65b0\uff0c\u4f46\u83b7\u5f97\u6027\u8010\u836f\u4e00\u76f4\u662fCML\u6cbb\u7597\u7684\u4e3b\u8981\u6311\u6218\u3002BCR-ABL\u6fc0\u9176\u533a\u7a81\u53d8\u662f\u83b7\u5f97\u6027\u8010\u836f\u7684\u91cd\u8981\u673a\u5236\u4e4b\u4e00\uff0c\u4e34\u5e8a\u4e0a\u4e9f\u9700\u5b89\u5168\u6709\u6548\u7684\u65b0\u4e00\u4ee3\u836f\u7269\u3002\u8010\u7acb\u514b®<\/sup>\u4e3a\u4e9a\u76db\u533b\u836f\u5f00\u53d1\u7684\u6f5c\u5728\u5168\u7403\u540c\u7c7b\u6700\u4f73\uff08Best-in-class\uff09\u65b0\u836f\uff0c\u83b7\u56fd\u5bb6"\u91cd\u5927\u65b0\u836f\u521b\u5236"\u4e13\u9879\u652f\u6301\u3002\u8010\u7acb\u514b®<\/sup>\u4f5c\u4e3a\u4e2d\u56fd\u9996\u4e2a\u4e14\u552f\u4e00\u83b7\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3\u9776\u5411BCR-ABL\u8010\u836fCML\u6cbb\u7597\u836f\u7269\uff0c\u5bf9BCR-ABL\u4ee5\u53ca\u5305\u62ecT315I\u7a81\u53d8\u5728\u5185\u7684\u591a\u79cdBCR-ABL\u7a81\u53d8\u4f53\u6709\u7a81\u51fa\u6548\u679c\u3002<\/p>\n

\u8010\u7acb\u514b<\/b>®<\/sup><\/b>\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b66\u8840\u6db2\u75c5\u7814\u7a76\u6240\u6240\u957f\u3001\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662\u8840\u6db2\u79d1\u4e3b\u4efb\u9ec4\u6653\u519b\u6559\u6388<\/b>\u8868\u793a\uff1a"\u6b64\u524d\u8010\u7acb\u514b®<\/sup>\u7684\u83b7\u6279\u89e3\u5f00\u4e86\u4e2d\u56fd\u643aT315I\u7a81\u53d8\u8010\u836fCML\u60a3\u8005\u7684\u65e0\u836f\u53ef\u533b\u7684\u56f0\u5c40\u3002\u4f46\u6709\u66f4\u591a\u4e00\u4ee3\u3001\u4e8c\u4ee3TKI\u8010\u836f\/\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u4f9d\u65e7\u7f3a\u4e4f\u6709\u6548\u6cbb\u7597\u65b9\u6848\uff0c\u514b\u670dTKI\u8010\u836f\u4ecd\u7136\u662fCML\u6cbb\u7597\u9886\u57df\u9762\u4e34\u7684\u6311\u6218\u3002\u8fd1\u5e74\u6765\uff0c\u8010\u7acb\u514b®<\/sup>\u7684\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u9010\u6b65\u5370\u8bc1\u4e86\u8be5\u836f\u7269\u5728\u8010\u836fCML\u8fd9\u4e2a\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u9886\u57df\u6f5c\u529b\u5de8\u5927\u3002\u6211\u4eec\u975e\u5e38\u671f\u5f85\u8be5\u836f\u7269\u518d\u6b21\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u540e\uff0c\u80fd\u65e9\u65e5\u8ba9\u66f4\u591a\u8010\u836fCML\u60a3\u8005\u53d7\u76ca\u3002"<\/p>\n

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\u5173\u4e8e\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5<\/b><\/p>\n

\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08Chronic Myeloid Leukemia, CML\uff09\uff0c\u662f\u9aa8\u9ad3\u9020\u8840\u5e72\u7ec6\u80de\u514b\u9686\u6027\u589e\u6b96\u5f62\u6210\u7684\u6076\u6027\u80bf\u7624\uff0c\u4e5f\u88ab\u79f0\u4e3a\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\uff0c\u662f\u6162\u6027\u767d\u8840\u75c5\u4e2d\u6700\u5e38\u89c1\u7684\u4e00\u79cd\u7c7b\u578b\uff0c\u5360\u6210\u4eba\u767d\u8840\u75c5\u768415%\u3002\u4e2d\u56fdCML\u60a3\u8005\u53d1\u75c5\u8f83\u897f\u65b9\u66f4\u4e3a\u5e74\u8f7b\u5316\uff0c\u6d41\u884c\u75c5\u5b66\u8c03\u67e5\u663e\u793a\uff0c\u4e2d\u56fdCML\u7684\u4e2d\u4f4d\u53d1\u75c5\u5e74\u9f84\u4e3a45~50\u5c81\uff0c\u897f\u65b9\u56fd\u5bb6CML\u7684\u4e2d\u4f4d\u53d1\u75c5\u5e74\u9f84\u4e3a67\u5c81\u3002<\/p>\n

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\u6b64\u6b21\u53d7\u7406\u53ca\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u662f\u57fa\u4e8e\u4e00\u9879\u5f00\u653e\u3001\u968f\u673a\u5bf9\u7167\u7684\u786e\u8bc1\u6027\u5173\u952e\u6ce8\u518cII\u671f\u7814\u7a76\uff08HQP1351CC203\u7814\u7a76\uff09\uff0c2021\u5e743\u6708CDE\u5df2\u57fa\u4e8e\u6b64\u9879\u7814\u7a76\u5c06\u8010\u7acb\u514b®\u7eb3\u5165\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\u3002\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u8010\u7acb\u514b®\u5728\u4e00\u4ee3\u548c\u4e8c\u4ee3TKIs\u8010\u836f\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u3001\u5b89\u5168\u6027\uff0c\u5171\u5165\u7ec4144\u4f8b\u53d7\u8bd5\u8005\uff0c\u968f\u673a\u5206\u914d\u5230\u8010\u7acb\u514b®\u6cbb\u7597\u7ec4\u548c\u73b0\u6709\u6700\u4f73\u6cbb\u7597\uff08Best Available Treatment, BAT\uff09\u5bf9\u7167\u7ec4\uff0c\u4ee5\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u4e3a\u4e3b\u8981\u7ec8\u70b9\u6307\u6807\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a\u8010\u7acb\u514b®\u76f8\u6bd4\u5bf9\u7167\u7ec4\u663e\u8457\u5ef6\u957f\u4e86EFS\uff0c\u8fbe\u5230\u4e86\u9884\u8bbe\u7684\u4f18\u6548\u6807\u51c6\u3002\u5177\u4f53\u7814\u7a76\u6570\u636e\u5c06\u5728\u672a\u6765\u76f8\u5173\u5b66\u672f\u4f1a\u8bae\u4e0a\u8fdb\u884c\u62ab\u9732\u3002 CML\u662f\u4e00\u79cd\u4e0e\u767d\u7ec6\u80de\u6709\u5173\u7684\u6076\u6027\u80bf\u7624\u3002\u968f\u7740\u9776\u5411BCR-ABL\u7684TKI\u836f\u7269\u4e0a\u5e02\uff0c\u9488\u5bf9CML\u7684\u6cbb\u7597\u65b9\u5f0f\u5f97\u4ee5\u9769\u65b0\uff0c\u4f46\u83b7\u5f97\u6027\u8010\u836f\u4e00\u76f4\u662fCML\u6cbb\u7597\u7684\u4e3b\u8981\u6311\u6218\u3002BCR-ABL\u6fc0\u9176\u533a\u7a81\u53d8\u662f\u83b7\u5f97\u6027\u8010\u836f\u7684\u91cd\u8981\u673a\u5236\u4e4b\u4e00\uff0c\u4e34\u5e8a\u4e0a\u4e9f\u9700\u5b89\u5168\u6709\u6548\u7684\u65b0\u4e00\u4ee3\u836f\u7269\u3002\u8010\u7acb\u514b®\u4e3a\u4e9a\u76db\u533b\u836f\u5f00\u53d1\u7684\u6f5c\u5728\u5168\u7403\u540c\u7c7b\u6700\u4f73\uff08Best-in-class\uff09\u65b0\u836f\uff0c\u83b7\u56fd\u5bb6"\u91cd\u5927\u65b0\u836f\u521b\u5236"\u4e13\u9879\u652f\u6301\u3002\u8010\u7acb\u514b®\u4f5c\u4e3a\u4e2d\u56fd\u9996\u4e2a\u4e14\u552f\u4e00\u83b7\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3\u9776\u5411BCR-ABL\u8010\u836fCML\u6cbb\u7597\u836f\u7269\uff0c\u5bf9BCR-ABL\u4ee5\u53ca\u5305\u62ecT315I\u7a81\u53d8\u5728\u5185\u7684\u591a\u79cdBCR-ABL\u7a81\u53d8\u4f53\u6709\u7a81\u51fa\u6548\u679c\u3002 \u8010\u7acb\u514b®\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b66\u8840\u6db2\u75c5\u7814\u7a76\u6240\u6240\u957f\u3001\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662\u8840\u6db2\u79d1\u4e3b\u4efb\u9ec4\u6653\u519b\u6559\u6388\u8868\u793a\uff1a"\u6b64\u524d\u8010\u7acb\u514b®\u7684\u83b7\u6279\u89e3\u5f00\u4e86\u4e2d\u56fd\u643aT315I\u7a81\u53d8\u8010\u836fCML\u60a3\u8005\u7684\u65e0\u836f\u53ef\u533b\u7684\u56f0\u5c40\u3002\u4f46\u6709\u66f4\u591a\u4e00\u4ee3\u3001\u4e8c\u4ee3TKI\u8010\u836f\/\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u4f9d\u65e7\u7f3a\u4e4f\u6709\u6548\u6cbb\u7597\u65b9\u6848\uff0c\u514b\u670dTKI\u8010\u836f\u4ecd\u7136\u662fCML\u6cbb\u7597\u9886\u57df\u9762\u4e34\u7684\u6311\u6218\u3002\u8fd1\u5e74\u6765\uff0c\u8010\u7acb\u514b®\u7684\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u9010\u6b65\u5370\u8bc1\u4e86\u8be5\u836f\u7269\u5728\u8010\u836fCML\u8fd9\u4e2a\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u9886\u57df\u6f5c\u529b\u5de8\u5927\u3002\u6211\u4eec\u975e\u5e38\u671f\u5f85\u8be5\u836f\u7269\u518d\u6b21\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u540e\uff0c\u80fd\u65e9\u65e5\u8ba9\u66f4\u591a\u8010\u836fCML\u60a3\u8005\u53d7\u76ca\u3002" \u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a"\u4f5c\u4e3a\u4e00\u5bb6\u81f4\u529b\u4e8e\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u672a\u88ab\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u7684\u521b\u65b0\u836f\u4f01\uff0c\u6211\u4eec\u4e00\u76f4\u5728\u5168\u901f\u63a8\u8fdb\u516c\u53f8\u54c1\u79cd\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u8ba9\u60a3\u8005\u5c3d\u65e9\u4ece\u4e9a\u76db\u533b\u836f\u7684\u521b\u65b0\u6210\u679c\u4e2d\u83b7\u76ca\u3002\u6b64\u6b21\u8010\u7acb\u514b®\u7684\u4e0a\u5e02\u7533\u8bf7\u83b7CDE\u53d7\u7406\u5e76\u88ab\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff0c\u4f53\u73b0\u4e86\u56fd\u5bb6\u836f\u54c1\u76d1\u7ba1\u90e8\u95e8\u5bf9\u8010\u836fCML\u9886\u57df\u4e34\u5e8a\u7a7a\u767d\u7684\u91cd\u89c6\uff0c\u66f4\u4ee3\u8868\u5176\u5bf9\u8010\u7acb\u514b®\u8fd9\u4e00\u521b\u65b0\u836f\u7684\u8ba4\u53ef\u3002\u6211\u4eec\u5c06\u7ee7\u7eed\u4e0e\u76f8\u5173\u90e8\u95e8\u7d27\u5bc6\u5408\u4f5c\uff0c\u63a8\u52a8\u5176\u65e9\u65e5\u83b7\u6279\uff0c\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002" \u4fe1\u8fbe\u751f\u7269\u9ad8\u7ea7\u526f\u603b\u88c1\u5468\u8f89\u535a\u58eb\u8868\u793a\uff1a"\u6211\u4eec\u5f88\u9ad8\u5174\u8010\u7acb\u514b®\u5728\u4e2d\u56fd\u9012\u4ea4\u7684\u4e0a\u5e02\u7533\u8bf7\u6210\u529f\u83b7\u53d7\u7406\u5e76\u88ab\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff0c\u671f\u5f85\u66f4\u5e7f\u9614\u7684TKI\u8010\u836fCML\u60a3\u8005\u80fd\u65e9\u65e5\u56e0\u6b64\u83b7\u76ca\u3002\u4fe1\u8fbe\u751f\u7269\u5728\u8840\u6db2\u7624\u9886\u57df\u62e5\u6709\u6210\u68af\u961f\u7684\u521b\u65b0\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u6211\u4eec\u5c06\u79c9\u6301’\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f’\u7684\u4f7f\u547d\uff0c\u4e3a\u66f4\u591a\u60a3\u8005\u548c\u5bb6\u5ead\u5e26\u53bb\u5e0c\u671b\u3002" \u5173\u4e8e\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5 \u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08Chronic Myeloid Leukemia, CML\uff09\uff0c\u662f\u9aa8\u9ad3\u9020\u8840\u5e72\u7ec6\u80de\u514b\u9686\u6027\u589e\u6b96\u5f62\u6210\u7684\u6076\u6027\u80bf\u7624\uff0c\u4e5f\u88ab\u79f0\u4e3a\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\uff0c\u662f\u6162\u6027\u767d\u8840\u75c5\u4e2d\u6700\u5e38\u89c1\u7684\u4e00\u79cd\u7c7b\u578b\uff0c\u5360\u6210\u4eba\u767d\u8840\u75c5\u768415%\u3002\u4e2d\u56fdCML\u60a3\u8005\u53d1\u75c5\u8f83\u897f\u65b9\u66f4\u4e3a\u5e74\u8f7b\u5316\uff0c\u6d41\u884c\u75c5\u5b66\u8c03\u67e5\u663e\u793a\uff0c\u4e2d\u56fdCML\u7684\u4e2d\u4f4d\u53d1\u75c5\u5e74\u9f84\u4e3a45~50\u5c81\uff0c\u897f\u65b9\u56fd\u5bb6CML\u7684\u4e2d\u4f4d\u53d1\u75c5\u5e74\u9f84\u4e3a67\u5c81\u3002 \u968f\u7740\u9776\u5411BCR-ABL\u7684TKI\u836f\u7269\u4e0a\u5e02\uff0c\u9488\u5bf9CML\u7684\u6cbb\u7597\u65b9\u5f0f\u5f97\u4ee5\u9769\u65b0\uff0c\u4f46\u83b7\u5f97\u6027\u8010\u836f\u4e00\u76f4\u662fCML\u6cbb\u7597\u7684\u4e3b\u8981\u6311\u6218\uff0c\u800cBCR-ABL\u6fc0\u9176\u533a\u7a81\u53d8\u662f\u83b7\u5f97\u6027\u8010\u836f\u7684\u91cd\u8981\u673a\u5236\u4e4b\u4e00\u3002 \u5173\u4e8e\u8010\u7acb\u514b® \u8010\u7acb\u514b®\u662f\u4e9a\u76db\u533b\u836f\u539f\u521b1\u7c7b\u65b0\u836f\uff0c\u4e3a\u53e3\u670d\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5242\uff0c\u662f\u4e2d\u56fd\u9996\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u9776\u5411\u8010\u836fCML\u6cbb\u7597\u836f\u7269\uff0c\u5bf9BCR-ABL\u4ee5\u53ca\u5305\u62ecT315I\u7a81\u53d8\u5728\u5185\u7684\u591a\u79cdBCR-ABL\u7a81\u53d8\u4f53\u6709\u7a81\u51fa\u6548\u679c\uff0c\u83b7\u56fd\u5bb6"\u91cd\u5927\u65b0\u836f\u521b\u5236"\u4e13\u9879\u652f\u6301\u3002 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