\u7f8e\u56fd\u65e7\u91d1\u5c71\u548c\u4e2d\u56fd\u82cf\u5dde<\/span>2022\u5e747\u670819\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u514d\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\uff08glucagon-like peptide-1 receptor, GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u4f53\uff08glucagon receptor, GCGR\uff09\u53cc\u91cd\u6fc0\u52a8\u5242mazdutide\uff08\u7814\u53d1\u4ee3\u53f7\uff1aIBI362\uff09\u5728\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8bd5\u8005\u4e2d\u7684\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5b89\u6170\u5242\/\u5ea6\u62c9\u7cd6\u80bd\u5bf9\u7167\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\u3002<\/p>\n \u6b64\u9879\u7814\u7a76\uff08ClinicalTrials.gov, NCT04965506\uff09\u65e8\u5728\u8bc4\u4f30mazdutide\u5728\u7ecf\u81f3\u5c113\u4e2a\u6708\u751f\u6d3b\u65b9\u5f0f\u5e72\u9884\u4f34\u6216\u8005\u4e0d\u4f34\u7a33\u5b9a\u5242\u91cf\u4e8c\u7532\u53cc\u80cd\u6cbb\u7597\u540e\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\uff08HbA1c\uff09\u4ecd\u4e0d\u8fbe\u6807\u7684\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8bd5\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u5171\u5165\u7ec4252\u4f8b\u53d7\u8bd5\u8005\uff0c\u968f\u673a\u63a5\u53d7mazdutide 3.0 mg\u30014.5 mg\u62166.0 mg\u3001\u5b89\u6170\u5242\u6216\u5ea6\u62c9\u7cd6\u80bd1.5 mg\uff0c\u6bcf\u5468\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\uff0c\u8fde\u7eed\u7ed9\u836f20\u5468\uff08\u542b4\u5468\u62168\u5468\u6ef4\u5b9a\u671f\uff09\u3002\u7814\u7a76\u4e3b\u8981\u7ec8\u70b9\u4e3a\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u8fde\u7eed\u7ed9\u836f20\u5468\u540eHbA1c\u8f83\u57fa\u7ebf\u7684\u53d8\u5316\u3002\u5404\u7ec4\u53d7\u8bd5\u8005\u5e73\u5747\u7cd6\u5c3f\u75c5\u75c5\u53f2\u4e3a4.0~5.7\u5e74\uff0cHbA1c\u57fa\u7ebf\u5e73\u5747\u503c\u57287.94%~8.16%\u4e4b\u95f4\u3002<\/p>\n \u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c<\/b>mazdutide\u5404\u5242\u91cf\u7ec4\u5747\u80fd\u663e\u8457\u964d\u4f4e\u53d7\u8bd5\u8005HbA1c\u6c34\u5e73\uff08\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4, p\u503c\u5747\u5c0f\u4e8e0.0001\uff09\u3002<\/b>\u7ed9\u836f20\u5468\u540e\uff0cmazdutide\u5404\u5242\u91cf\u7ec4HbA1c\u6c34\u5e73\u8f83\u57fa\u7ebf\u53d8\u5316\u7684\u6700\u5c0f\u4e8c\u4e58\u5747\u503c\u5206\u522b\u4e3a\u22121.41%\uff0895%CI\uff1a\u22121.70, \u22121.13\uff1b3.0 mg\uff09\u3001\u22121.67%\uff08\u22121.95, \u22121.39\uff1b4.5 mg\uff09\u548c\u22121.54%\uff08\u22121.83, \u22121.25\uff1b6.0 mg\uff09\uff0c\u5ea6\u62c9\u7cd6\u80bd1.5 mg\u7ec4\u4e3a\u22121.35% (\u22121.63, \u22121.07)\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a0.03%\uff08\u22120.25, 0.31\uff09\uff1bMazdutide\u7ec4HbA1c < 7.0%\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\u5206\u522b\u4e3a62.8%\uff083.0 mg\uff09\u300174.4%\uff084.5 mg\uff09\u548c78.3%\uff086.0 mg\uff09\uff1b\u5ea6\u62c9\u7cd6\u80bd1.5 mg\u7ec4\u4e3a69.8%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a20.0%\u3002<\/p>\n \u5728\u53d7\u8bd5\u8005\u7684\u4f53\u91cd\u7ba1\u7406\u65b9\u9762\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c<\/b>mazdutide\u5404\u5242\u91cf\u5747\u53ef\u663e\u8457\u964d\u4f4e\u4f53\u91cd\uff0c\u4e14\u5448\u73b0\u5242\u91cf\u4f9d\u8d56\u6027\u3002<\/b>\u7ed9\u836f20\u5468\u540e\uff0cMazdutide 6.0 mg\u7ec4\u4f53\u91cd\u8f83\u57fa\u7ebf\u767e\u5206\u6bd4\u53d8\u5316\u7684\u6700\u5c0f\u4e8c\u4e58\u5747\u503c\u4e3a\u22127.14%\uff0895%CI\uff1a\u22128.49, \u22125.79\uff09\uff0c\u5ea6\u62c9\u7cd6\u80bd1.5 mg\u7ec4\u4e3a\u22122.69%\uff08\u22124.02, \u22121.37\uff09\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a\u22121.38%\uff08\u22122.70, \u22120.06\uff09\uff0c\u4e0e\u5ea6\u62c9\u7cd6\u80bd\u7ec4\u548c\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0cp\u503c\u5747\u5c0f\u4e8e0.0001\uff1bmazdutide 6.0 mg \u7ec4HbA1c<7.0%\u4e14\u4f53\u91cd\u8f83\u57fa\u7ebf\u4e0b\u964d\u22655%\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\u9ad8\u8fbe52.2%\uff08\u5ea6\u62c9\u7cd6\u80bd1.5 mg\u7ec4\u4e3a14.0%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a0%\uff09\u3002<\/p>\n \u540c\u65f6\uff0cmazdutide\u8fd8\u53ef\u964d\u4f4e\u7a7a\u8179\u8840\u7cd6\u3001\u9910\u540e\u8840\u7cd6\u3001\u8840\u538b\u3001\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\u548c\u7518\u6cb9\u4e09\u916f\u7b49\u6307\u6807\uff0c\u5e76\u6539\u5584\u80f0\u5c9b\u7d20\u654f\u611f\u6027\uff0c\u4e3a\u60a3\u8005\u5e26\u6765\u5168\u9762\u83b7\u76ca<\/b>\u3002<\/p>\n Mazdutide\u603b\u4f53\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002<\/b>\u65e0\u53d7\u8bd5\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u63d0\u524d\u9000\u51fa\u7814\u7a76\u3002\u7814\u7a76\u671f\u95f4\u672a\u53d1\u751f\u91cd\u5ea6\u4f4e\u8840\u7cd6\u4e8b\u4ef6\u3002\u6574\u4f53\u5b89\u5168\u6027\u7279\u5f81\u4e0emazdutide\u7684\u65e2\u5f80\u7814\u7a76\u548c\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u7c7b\u836f\u7269\u76f8\u4f3c\u3002\u6700\u5e38\u62a5\u544a\u7684\u6cbb\u7597\u671f\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u98df\u6b32\u51cf\u9000\u3001\u6076\u5fc3\u3001\u5455\u5410\u548c\u8179\u6cfb\uff0c\u591a\u4e3a\u8f7b\u5ea6\u6216\u4e2d\u5ea6\u4e14\u5448\u4e00\u8fc7\u6027\u7279\u5f81\u3002<\/p>\n \u672c\u7814\u7a76\u7684\u6570\u636e\u8fd8\u5728\u8fdb\u4e00\u6b65\u6574\u7406\u548c\u5206\u6790\u4e2d\uff0c\u76f8\u5173\u7ed3\u679c\u5c06\u4f1a\u5728\u540c\u884c\u8bc4\u5ba1\u7684\u5b66\u672f\u671f\u520a\u53d1\u8868\u3002<\/p>\n CIBI362A201\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u65e5\u53cb\u597d\u533b\u9662\u6768\u6587\u82f1\u6559\u6388<\/b>\u8868\u793a\uff1a\u201c\u76ee\u524d\uff0c\u6211\u56fd2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4ecd\u5b58\u5728\u8840\u7cd6\u603b\u4f53\u8fbe\u6807\u7387\u504f\u4f4e\uff0c\u4e14\u60a3\u8005\u5f80\u5f80\u5408\u5e76\u591a\u79cd\u5fc3\u8840\u7ba1\u98ce\u9669\u56e0\u7d20\uff0c\u5982\u80a5\u80d6\u3001\u9ad8\u8102\u8840\u75c7\u3001\u51a0\u5fc3\u75c5\u3001\u8102\u80aa\u809d\u3001\u75db\u98ce\u7b49\u60c5\u51b5\uff0c\u8fd9\u65e2\u589e\u52a0\u4e86\u60a3\u8005\u7684\u75be\u75c5\u8d1f\u62c5\uff0c\u4e5f\u7ed9\u533b\u751f\u6cbb\u7597\u589e\u52a0\u4e86\u96be\u5ea6\u548c\u590d\u6742\u6027\uff1b\u4e34\u5e8a\u4e0a\u8feb\u5207\u9700\u8981\u80fd\u6709\u7597\u6548\u786e\u5207\uff0c\u5b89\u5168\u6027\u597d\uff0c\u7ed9\u836f\u4fbf\u6377\uff0c\u4f4e\u8840\u7cd6\u98ce\u9669\u4f4e\uff0c\u4e14\u80fd\u5b9e\u73b0\u591a\u79cd\u5fc3\u8840\u7ba1\u83b7\u76ca\u7684\u521b\u65b0\u836f\u7269\u3002\u6211\u5f88\u9ad8\u5174\u5730\u770b\u5230\u65b0\u4e00\u4ee3GLP-1R\/ 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\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\u4e34\u5e8a\u526f\u603b\u88c1\u94b1\u956d\u535a\u58eb<\/b>\u8868\u793a\uff1a\u201cMazdutide\u662f\u9996\u4e2a\u517c\u5177\u5f3a\u6548\u964d\u7cd6\u548c\u51cf\u91cd\u7597\u6548\u7684\u5468\u5236\u5242GLP-1R\/GCGR\u53cc\u91cd\u6fc0\u52a8\u5242\u3002Mazdutide\u5728\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\u76842\u671f\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u5176\u5728\u964d\u7cd6\u3001\u51cf\u91cd\u548c\u7efc\u5408\u4ee3\u8c22\u83b7\u76ca\u65b9\u9762\u7684\u4f18\u52bf\u5f97\u5230\u5168\u9762\u9a8c\u8bc1\uff0c\u5e76\u5c55\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u8fd9\u4e3a\u6211\u4eec\u5373\u5c06\u5f00\u5c55\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\u5960\u5b9a\u4e86\u575a\u5b9e\u7684\u57fa\u7840\uff0c\u503c\u5f97\u6307\u51fa\u7684\u662f\uff0c\u6211\u4eec\u5728\u4e34\u5e8aII\u671f\u7814\u7a76\u4e2d\u5c31\u5b9e\u73b0\u4e86\u548c\u5ea6\u62c9\u7cd6\u80bd\uff081.5mg\uff09\u7684\u5bf9\u6bd4\uff0c\u5e76\u83b7\u5f97\u4e86\u632f\u594b\u4eba\u5fc3\u7684\u7ed3\u679c\uff0c\u8fd9\u5145\u5206\u5c55\u73b0\u4e86\u7533\u529e\u65b9\u5bf9mazdutide\u7684\u4fe1\u5fc3\u3002\u5728\u4e0e\u76d1\u7ba1\u673a\u6784\u5145\u5206\u6c9f\u901a\u7684\u57fa\u7840\u4e0a\uff0c\u6211\u4eec\u5c06\u66f4\u52a0\u79ef\u6781\u7684\u63a8\u8fdbIII\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u671f\u5f85\u80fd\u65e9\u65e5\u4e3a\u4e2d\u56fd\u7684\u533b\u751f\u548c\u7cd6\u5c3f\u75c5\u60a3\u8005\u5e26\u6765\u65b0\u7684\u4e34\u5e8a\u836f\u7269\u9009\u62e9\u3002\u201d<\/p>\n 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\u5173\u4e8e<\/b>Mazdutide\uff08IBI362\uff09<\/b><\/p>\n Mazdutide\uff08IBI362\uff09\u662f\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u4e0e\u793c\u6765\u5236\u836f\u5171\u540c\u63a8\u8fdb\u7684\u4e00\u6b3e\u80c3\u6ccc\u9178\u8c03\u8282\u7d20\u521b\u65b0\u5316\u5408\u7269\uff08OXM3\uff09\uff0c\u5728\u540c\u7c7b\u4ea7\u54c1\u4e2d\u5177\u6709\u6700\u4f18\u6f5c\u529b\u3002\u4f5c\u4e3a\u4e00\u79cd\u4e0e\u54fa\u4e73\u52a8\u7269\u80c3\u6ccc\u9178\u8c03\u8282\u7d20\u7c7b\u4f3c\u7684\u957f\u6548\u5408\u6210\u80bd\uff0cmazdutide\u5229\u7528\u8102\u80aa\u9170\u57fa\u4fa7\u94fe\u5ef6\u957f\u4f5c\u7528\u65f6\u95f4\uff0c\u5141\u8bb8\u6bcf\u5468\u7ed9\u836f\u4e00\u6b21\u3002mazdutide\u7684\u4f5c\u7528\u88ab\u8ba4\u4e3a\u662f\u901a\u8fc7GLP-1R\u548cGCGR\u7684\u7ed3\u5408\u548c\u6fc0\u6d3b\u4ecb\u5bfc\u7684\uff0c\u4e0eOXM\u5177\u6709\u76f8\u4f3c\u4f5c\u7528\u673a\u5236\uff0c\u56e0\u6b64\u9884\u8ba1\u5176\u53ef\u4ee5\u6539\u5584\u8461\u8404\u7cd6\u8010\u91cf\u5e76\u51cf\u8f7b\u4f53\u91cd\u3002\u9664\u4e86GLP-1R\u6fc0\u52a8\u5242\u5177\u6709\u7684\u4fc3\u8fdb\u80f0\u5c9b\u7d20\u5206\u6ccc\u3001\u964d\u4f4e\u8840\u7cd6\u548c\u51cf\u8f7b\u4f53\u91cd\u7b49\u4f5c\u7528\u5916\uff0cmazdutide\u8fd8\u53ef\u80fd\u901a\u8fc7GCGR\u7684\u6fc0\u6d3b\u5177\u6709\u589e\u52a0\u80fd\u91cf\u6d88\u8017\u548c\u6539\u5584\u809d\u810f\u8102\u80aa\u4ee3\u8c22\u7b49\u6548\u5e94\u3002\u901a\u8fc7\u5f00\u53d1\u540c\u65f6\u6fc0\u52a8\u591a\u4e2a\u4e0e\u4ee3\u8c22\u76f8\u5173\u7684\u9776\u70b9\u6765\u6cbb\u7597\u4ee3\u8c22\u6027\u75be\u75c5\u662f\u76ee\u524d\u56fd\u9645\u4e0a\u65b0\u836f\u7814\u53d1\u6700\u65b0\u7684\u8d8b\u52bf\u3002<\/p>\n \u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n \u201c\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c\u201d\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u7406\u60f3\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u75be\u75c5\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u30022018\u5e7410\u670831\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a01801\u3002<\/p>\n 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\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u201c\u9884\u671f\u201d\u3001\u201c\u76f8\u4fe1\u201d\u3001\u201c\u9884\u6d4b\u201d\u3001\u201c\u671f\u671b\u201d\u3001\u201c\u6253\u7b97\u201d\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u5e76\u65e0\u4e49\u52a1\u4e0d\u65ad\u5730\u66f4\u65b0\u8fd9\u4e9b\u9884\u6d4b\u6027\u9648\u8ff0\u3002<\/p>\n 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\u7f8e\u56fd\u65e7\u91d1\u5c71\u548c\u4e2d\u56fd\u82cf\u5dde2022\u5e747\u670819\u65e5 \/\u7f8e\u901a\u793e\/ — \u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u514d\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\uff08glucagon-like peptide-1 receptor, GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u4f53\uff08glucagon receptor, GCGR\uff09\u53cc\u91cd\u6fc0\u52a8\u5242mazdutide\uff08\u7814\u53d1\u4ee3\u53f7\uff1aIBI362\uff09\u5728\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8bd5\u8005\u4e2d\u7684\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5b89\u6170\u5242\/\u5ea6\u62c9\u7cd6\u80bd\u5bf9\u7167\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\u3002 \u6b64\u9879\u7814\u7a76\uff08ClinicalTrials.gov, NCT04965506\uff09\u65e8\u5728\u8bc4\u4f30mazdutide\u5728\u7ecf\u81f3\u5c113\u4e2a\u6708\u751f\u6d3b\u65b9\u5f0f\u5e72\u9884\u4f34\u6216\u8005\u4e0d\u4f34\u7a33\u5b9a\u5242\u91cf\u4e8c\u7532\u53cc\u80cd\u6cbb\u7597\u540e\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\uff08HbA1c\uff09\u4ecd\u4e0d\u8fbe\u6807\u7684\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8bd5\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u5171\u5165\u7ec4252\u4f8b\u53d7\u8bd5\u8005\uff0c\u968f\u673a\u63a5\u53d7mazdutide 3.0 mg\u30014.5 mg\u62166.0 mg\u3001\u5b89\u6170\u5242\u6216\u5ea6\u62c9\u7cd6\u80bd1.5 mg\uff0c\u6bcf\u5468\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\uff0c\u8fde\u7eed\u7ed9\u836f20\u5468\uff08\u542b4\u5468\u62168\u5468\u6ef4\u5b9a\u671f\uff09\u3002\u7814\u7a76\u4e3b\u8981\u7ec8\u70b9\u4e3a\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u8fde\u7eed\u7ed9\u836f20\u5468\u540eHbA1c\u8f83\u57fa\u7ebf\u7684\u53d8\u5316\u3002\u5404\u7ec4\u53d7\u8bd5\u8005\u5e73\u5747\u7cd6\u5c3f\u75c5\u75c5\u53f2\u4e3a4.0~5.7\u5e74\uff0cHbA1c\u57fa\u7ebf\u5e73\u5747\u503c\u57287.94%~8.16%\u4e4b\u95f4\u3002 \u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0cmazdutide\u5404\u5242\u91cf\u7ec4\u5747\u80fd\u663e\u8457\u964d\u4f4e\u53d7\u8bd5\u8005HbA1c\u6c34\u5e73\uff08\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4, p\u503c\u5747\u5c0f\u4e8e0.0001\uff09\u3002\u7ed9\u836f20\u5468\u540e\uff0cmazdutide\u5404\u5242\u91cf\u7ec4HbA1c\u6c34\u5e73\u8f83\u57fa\u7ebf\u53d8\u5316\u7684\u6700\u5c0f\u4e8c\u4e58\u5747\u503c\u5206\u522b\u4e3a\u22121.41%\uff0895%CI\uff1a\u22121.70, \u22121.13\uff1b3.0 mg\uff09\u3001\u22121.67%\uff08\u22121.95, \u22121.39\uff1b4.5 mg\uff09\u548c\u22121.54%\uff08\u22121.83, \u22121.25\uff1b6.0 mg\uff09\uff0c\u5ea6\u62c9\u7cd6\u80bd1.5 mg\u7ec4\u4e3a\u22121.35% (\u22121.63, \u22121.07)\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a0.03%\uff08\u22120.25, 0.31\uff09\uff1bMazdutide\u7ec4HbA1c < 7.0%\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\u5206\u522b\u4e3a62.8%\uff083.0 mg\uff09\u300174.4%\uff084.5 mg\uff09\u548c78.3%\uff086.0 mg\uff09\uff1b\u5ea6\u62c9\u7cd6\u80bd1.5 mg\u7ec4\u4e3a69.8%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a20.0%\u3002 \u5728\u53d7\u8bd5\u8005\u7684\u4f53\u91cd\u7ba1\u7406\u65b9\u9762\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0cmazdutide\u5404\u5242\u91cf\u5747\u53ef\u663e\u8457\u964d\u4f4e\u4f53\u91cd\uff0c\u4e14\u5448\u73b0\u5242\u91cf\u4f9d\u8d56\u6027\u3002\u7ed9\u836f20\u5468\u540e\uff0cMazdutide 6.0 mg\u7ec4\u4f53\u91cd\u8f83\u57fa\u7ebf\u767e\u5206\u6bd4\u53d8\u5316\u7684\u6700\u5c0f\u4e8c\u4e58\u5747\u503c\u4e3a\u22127.14%\uff0895%CI\uff1a\u22128.49, \u22125.79\uff09\uff0c\u5ea6\u62c9\u7cd6\u80bd1.5 mg\u7ec4\u4e3a\u22122.69%\uff08\u22124.02, \u22121.37\uff09\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a\u22121.38%\uff08\u22122.70, \u22120.06\uff09\uff0c\u4e0e\u5ea6\u62c9\u7cd6\u80bd\u7ec4\u548c\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0cp\u503c\u5747\u5c0f\u4e8e0.0001\uff1bmazdutide 6.0 mg \u7ec4HbA1c<7.0%\u4e14\u4f53\u91cd\u8f83\u57fa\u7ebf\u4e0b\u964d\u22655%\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\u9ad8\u8fbe52.2%\uff08\u5ea6\u62c9\u7cd6\u80bd1.5 mg\u7ec4\u4e3a14.0%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a0%\uff09\u3002 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<\/i>2. \u4fe1\u8fbe\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u83b7\u6279\u7684\u836f\u54c1\/\u9002\u5e94\u75c7\u4f7f\u7528\u3002<\/i><\/p>\n