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– \u4e3b\u5e2d\u81f4\u8f9e –<\/b><\/p>\n

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\n

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\n

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\n

\"\u5317\u4eac\u9646\u9053\u57f9\u533b\u9662\u6c5f\u5cb7\u6559\u6388\u62c5\u4efb\u7b2c\u5341\u5c4a\u9646\u9053\u57f9\u8840\u6db2\u75c5\u9ad8\u5cf0\u8bba\u575b\u5927\u4f1a\u79d8\u4e66\u957f\"<\/a>
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\u4f1a\u8bae\u7531\u6c5f\u5cb7\u6559\u6388\u4e3b\u6301<\/p>\n

– \u5b66\u672f\u62a5\u544a –<\/b><\/p>\n

\u601d\u60f3\u78b0\u649e\uff0c\u58f0\u8d2f\u5343\u91cc<\/b><\/p>\n

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\u4e3b\u4f1a\u573a<\/b><\/p>\n

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\u65b0\u578bCAR-T\u7ec6\u80de\u6cbb\u7597T-ALL\u548cAML<\/p>\n

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AA\u4e0eMDS\u7684\u9274\u522b<\/p>\n

\u5929\u6d25\u533b\u79d1\u5927\u5b66\u603b\u533b\u9662\u90b5\u5b97\u9e3f\u6559\u6388\u91cd\u70b9\u4ecb\u7ecd\u4e86\u901a\u8fc7\u4e0d\u540c\u9274\u522b\u65b9\u6cd5\u5982\u8840\u8c61\u3001\u9aa8\u9ad3\u3001\u514d\u75ab\u7ec4\u5316\u3001\u67d3\u8272\u4f53\u3001\u57fa\u56e0\u4ee5\u53ca\u6cbb\u7597\u53cd\u5e94\u7b49\u7b49\u65b9\u9762\u4ecb\u7ecd\u4e86AA\u4e0eMDS\u7684\u4e0d\u540c\u8868\u73b0\uff0c\u5e76\u603b\u7ed3\u5230\u767d\u8840\u75c5\u7684\u827a\u672f\u5728\u6cbb\u7597\uff0c\u518d\u969c\u7684\u827a\u672f\u5728\u8bca\u65ad\u3002<\/p>\n

\u5916\u5468T\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u7cbe\u51c6\u8bca\u6cbb<\/p>\n

\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u745e\u91d1\u533b\u9662\u8d75\u7ef4\u8385\u6559\u6388\u8be6\u7ec6\u4ecb\u7ecd\u4e86PTCL\u9884\u540e\u5206\u5c42\u7684\u4e34\u5e8a\u610f\u4e49\u3001\u4e0d\u540c\u8bca\u65ad\u65b9\u6cd5\uff0c\u56de\u987e\u6027\u5206\u6790\u4e86\u591a\u4e2d\u5fc3\u6700\u65b0\u8fdb\u5c55\u548c\u4e34\u5e8a\u7814\u7a76\uff0c\u5206\u4eab\u4e86\u5173\u4e8ePTCL\u7684\u4e34\u5e8a\u6cbb\u7597\u7ecf\u9a8c\u3002<\/p>\n

EBV\u76f8\u5173\u8840\u6db2\u7cfb\u7edf\u75be\u75c5\u8bca\u7597\u8fdb\u5c55<\/p>\n

\u5317\u4eac\u53cb\u8c0a\u533b\u9662\u738b\u662d\u6559\u6388\u5206\u4eab\u4e86\u5b9d\u8d35\u7684\u7ecf\u9a8c\uff1a\u6d3b\u52a8\u6027EBV\u611f\u67d3\u60a3\u8005\u75c7\u72b6\u6301\u7eed\u4e0d\u7f13\u89e3\uff0c\u51fa\u73b0\u8fdb\u884c\u6027\u8840\u7ec6\u80de\u51cf\u5c11\uff0c\u809d\u529f\u80fd\u6301\u7eed\u6076\u5316\uff0c\u4f4e\u86cb\u767d\u8840\u75c7\uff0c\u94c1\u86cb\u767d\u660e\u663e\u5347\u9ad8\u65f6\uff0c\u9700\u8b66\u60d5HLH\u53ef\u80fd\u3002\u53ca\u65e9\u5b8c\u5584NK\u7ec6\u80de\u6d3b\u6027\uff0csCD25\u3001CD107a\uff0c\u7ec6\u80de\u56e0\u5b50\uff0cEBV\u611f\u67d3\u6dcb\u5df4\u7ec6\u80de\u4e9a\u7fa4\u7684\u68c0\u6d4b\uff0c\u6709\u5229\u4e8eEBV-HLH\u7684\u65e9\u671f\u8bca\u65ad\u53ca\u9274\u522b\u8bca\u65ad\u3002VP-16\u7684\u65e9\u671f\u5e94\u7528\u6709\u5229\u4e8e\u6539\u5584EBV-HLH\u60a3\u8005\u7684\u9884\u540e\uff0c\u76ee\u524d\u5c1a\u7f3a\u4e4f\u6301\u7eed\u6709\u6548\u7684\u6e05\u9664EBV\u7684\u836f\u7269\uff0callo-ASCT\u53ef\u80fd\u662f\u6700\u7ec8\u6839\u6cbb\u624b\u6bb5\u3002<\/p>\n

CAR-T\u4e0eaIIo-HSCT in B-ALL<\/p>\n

\u5f90\u5dde\u533b\u79d1\u5927\u5b66\u8840\u6db2\u75c5\u7814\u7a76\u6240\u5f90\u5f00\u6797\u6559\u6388\u5bf9\u6bd4\u5927\u91cf\u4e34\u5e8a\u6570\u636e\u5f97\u51fa\u7ed3\u8bba\uff0c\u79fb\u690d\u540e\u590d\u53d1\u7684B-ALL\u7528CAR-T\u53ef\u4ee5\u518d\u6b21\u7f13\u89e3\uff0c\u4e3a\u4e8c\u6b21\u79fb\u690d\u521b\u9020\u4e86\u65f6\u673a\uff0cCAR-T\u540e\u6865\u63a5\u79fb\u690d\u662f\u63d0\u9ad8\u6cbb\u6108\u7387\u7684\u6700\u6709\u6548\u7684\u624b\u6bb5\uff1b\u4e24\u8005\u5f3a\u5f3a\u8054\u5408\u7684\u4ef7\u503c\u6709\u5f85\u8fdb\u4e00\u6b65\u5f00\u53d1\u3002<\/p>\n

B\u6025\u6dcb\u79fb\u690d\u540e\u590d\u53d1\u7684\u6cbb\u7597<\/p>\n

\u9646\u9053\u57f9\u533b\u9662\u9aa8\u9ad3\u79fb\u690d\u79d1\u66f9\u661f\u7389\u4e3b\u4efb\uff0c\u76f8\u6bd4\u4f20\u7edf\u6cbb\u7597\u548c\u5355\u6297\uff0cCD19 CAR-T\u6cbb\u7597allo-HSCT\u540e\u590d\u53d1\u7684B-ALL\u60a3\u8005\u5b89\u5168\u548c\u6709\u6548\uff0c\u9700\u8981\u6839\u636e\u79fb\u690d\u540e\u60a3\u8005\u5177\u4f53\u60c5\u51b5\u9009\u62e9\u5408\u9002\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u76ee\u524d\u6cbb\u7597\u6a21\u5f0f\u4e0b\uff0cCR\u540e\u5927\u90e8\u5206\u60a3\u8005\u4ecd\u9700\u91c7\u7528\u5de9\u56fa\u548c\u7ef4\u6301\u6cbb\u7597\uff0c\u4eba\u6e90\u5316CAR-T\u5c55\u73b0\u4e86\u826f\u597d\u7684\u524d\u666f\u3002<\/p>\n

Maintenance therapy post allogeneic stem cell transplantation<\/p>\n

EBMT\u524d\u4e3b\u5e2d\u3001\u7d22\u90a6\u5927\u5b66\u5723\u5b89\u4e1c\u5c3c\u533b\u9662Mohamad Mohty\u6559\u6388\uff0c\u901a\u8fc7\u4e34\u5e8a\u6570\u636e\u7814\u7a76\u5206\u4eab\u4e86\u5173\u4e8e\u79fb\u690d\u540e\u7ef4\u6301\u6cbb\u7597\u7684\u5b9d\u8d35\u7ecf\u9a8c\u3002<\/p>\n

\u5148\u5929\u514d\u75ab\u9519\u8bef\u4e0e\u9020\u8840\u7cfb\u7edf\u80bf\u7624<\/p>\n

\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662\u5f20\u4e50\u840d\u6559\u6388\u901a\u8fc7\u5177\u4f53\u75c5\u4f8b\uff0c\u5bfc\u51fa\u5148\u5929\u514d\u75ab\u4e0e\u8840\u6db2\u80bf\u7624\u7684\u5173\u7cfb\uff0c\u5e76\u603b\u7ed3\u5148\u5929\u514d\u75ab\u9519\u8bef\uff08IEIs\uff09\u5f80\u5f80\u65e9\u671f\u8868\u73b0\u4e3a\u5bf9\u611f\u67d3\u548c\u708e\u75c7\u53cd\u5e94\u5e94\u7b54\u5931\u8861\uff0c\u5176\u4e2d\u67d0\u4e9b\u7c7b\u578b\u6613\u8fdb\u5c55\u4e3a\u80bf\u7624\uff0c\u9020\u8840\u7cfb\u7edf\u80bf\u7624\u7684\u53d1\u751f\u663e\u8457\u9ad8\u4e8e\u666e\u901a\u4eba\u7fa4\u3002\u57fa\u56e0\u6cbb\u7597\u662f\u672a\u6765\u65b9\u5411\uff0c\u9020\u8840\u5e72\u7ec6\u80de\u65f6\u673a\u53ca\u4f9b\u8005\u9009\u62e9\u503c\u5f97\u91cd\u89c6\u3002<\/p>\n

\u80bf\u7624\u4e2d\u67a2\u6dcb\u5df4\u7624CAR-T\u6cbb\u7597\u63a2\u7d22<\/p>\n

\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u6b66\u6c49\u540c\u6d4e\u533b\u9662\u8096\u6bc5\u6559\u6388\uff0c\u603b\u7ed3\u4e86\u76ee\u524d\u5173\u4e8e\u4e2d\u67a2\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u8ba4\u4e3a\u76ee\u524d\u4e2d\u67a2\u6dcb\u5df4\u7624\u4ecd\u7136\u662f\u9700\u8981\u9762\u5bf9\u7684\u96be\u9898\uff0cBKT\u3001PD-1\uff0c\u65b0\u7684\u7ec4\u5408\u65b9\u6848\u7b49\u53d6\u5f97\u4e86\u4e00\u5b9a\u7684\u7597\u6548\uff0cTBC\u81ea\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u5de9\u56fa\u63d0\u9ad8\u4e86\u90e8\u5206\u75c5\u4eba\u7597\u6548\uff0c\u4f46\u4ecd\u6709\u590d\u53d1\uff0c\u81ea\u4f53\u79fb\u690d\u6865\u63a5CAR-T\u6709\u671b\u6cbb\u6108\u3002<\/p>\n

\u518d\u969c\u5355\u500d\u4f53\u79fb\u690d\u4f5c\u4e3a\u4e00\u7ebf\u9009\u62e9<\/p>\n

\u5f20\u5efa\u5e73\u4e3b\u4efb\uff0c\u8d5b\u8bfa\u83f2\u536b\u661f\u4f1a\u4e0a\u8ba8\u8bba\u4e86SAA\u4e00\u7ebfHSCT\u63a2\u7d22\u66ff\u4ee3\u4f9b\u8005\u7684\u5fc5\u8981\u6027\uff0c\u6570\u636e\u8868\u660eSAA\u60a3\u8005\u65e0MSD\u65f6\u4e00\u7ebfMUD\u6216\u5355\u500d\u4f53HSCT\u7406\u7531\u5145\u5206\u3002<\/p>\n

\u4e3b\u6301\u5609\u5bbe\uff1a\u738b\u666f\u6587\u6559\u6388\u3001\u5b8b\u6c38\u5e73\u6559\u6388\u3001\u4efb\u91d1\u6d77\u6559\u6388\u3001\u9ad8\u7d20\u541b\u6559\u6388\u3001\u5b59\u81ea\u654f\u6559\u6388\u3001\u5ed6\u65b0\u751f\u6559\u6388\u3001\u9648\u9759\u6559\u6388\u3001\u5f20\u4f2f\u9f99\u6559\u6388\u3001\u5218\u5f00\u5f66\u6559\u6388<\/p>\n

CAR-T\u7ec6\u80de\u6cbb\u7597\/\u6dcb\u5df4\u7624\/\u9aa8\u9ad3\u7624\u4e13\u573a<\/b><\/p>\n

\u63a2\u7d22\u524d\u6cbf\u6cbb\u7597\u624b\u6bb5<\/b><\/p>\n

\u4e00\u76f4\u4ee5\u6765\uff0c\u8010\u836f\u53ca\u590d\u53d1\u7b49\u95ee\u9898\uff0c\u662f\u6cbb\u7597\u6dcb\u5df4\u7624\u3001\u9aa8\u9ad3\u7624\u7b49\u8840\u6db2\u7cfb\u7edf\u5e38\u89c1\u6076\u6027\u80bf\u7624\u65f6\u9762\u4e34\u7684\u4e3b\u8981\u96be\u9898\u3002\u9646\u9053\u57f9\u533b\u9662\u8840\u6db2\u79d1\u5f20\u5f26\u4e3b\u4efb\u5c31\u96be\u6cbb\u590d\u53d1T\u6dcb\u5df4\u6bcd\u7cfb\u767d\u8840\u75c5\/\u6dcb\u5df4\u7624\uff08R\/R LBL\/ALL\uff09\u7684\u6cbb\u7597\u63a2\u7d22\u5206\u4eab\u4e86\u7ecf\u9a8c\uff0cR\/R T LBL\/ALL\u9996\u9009\u8fd8\u662f\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\uff0c\u4f46\u79fb\u690d\u524d\u662f\u5426CR\uff0c\u7279\u522b\u662fMRD(-)CR\uff0c\u662f\u5f71\u54cd\u79fb\u690d\u6548\u679c\u7684\u5173\u952e\uff0cCD7 CAR-T\u7ec6\u80de\u6cbb\u7597\u7684CR\u7387\u6700\u9ad8\uff0880%\u4ee5\u4e0a\uff09\uff0c\u5efa\u8bae\u5c3d\u65e9\u8fdb\u884c\u3002\u5317\u4eac\u671d\u9633\u533b\u9662\u9648\u6587\u660e\u6559\u6388\u8be6\u7ec6\u9610\u8ff0\u4e862022 EHA\u4f1a\u8bae\u4e0a\u5173\u4e8e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\u3002<\/p>\n

\u76ee\u524d\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u4e3b\u8981\u67094\u5927\u7c7b\u578b\uff1a\u514d\u75ab\u68c0\u67e5\u70b9\u6cbb\u7597\u3001\u53cc\u7279\u5f02\u6027\u6297\u4f53BITE\u3001\u6297\u4f53\u53caADC\u6cbb\u7597\u4ee5\u53caCAR-T\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u3002\u5982\u4f55\u66f4\u79d1\u5b66\u6709\u6548\u7684\u8fd0\u7528\u591a\u79cd\u624b\u6bb5\uff1f\u89e3\u653e\u519b\u603b\u533b\u9662\u7b2c\u4e00\u533b\u5b66\u4e2d\u5fc3\u97e9\u4e3a\u4e1c\u6559\u6388\u5206\u4eab\u4e86Combination of epigenetic agents with anti-PD-1 in the treatment of r\/r cHL\u7684\u7ecf\u9a8c\u3002\u4e0a\u6d77\u540c\u6d4e\u533b\u9662\u6881\u7231\u658c\u6559\u6388\u5728\u9898\u4e3a"\u8868\u89c2\u9057\u4f20\u5b66\u4e0e\u514d\u75ab\u6cbb\u7597"\u7684\u62a5\u544a\u4e2d\uff0c\u6307\u51fa\u8868\u89c2\u9057\u4f20\u5b66\u7684\u514d\u75ab\u8c03\u63a7\uff0c\u80fd\u591f\u9884\u6d4b\u548c\u5224\u65ad\u548c\u63d0\u9ad8\u4e34\u5e8a\u7684\u7597\u6548\u3002\u5929\u6d25\u533b\u79d1\u5927\u5b66\u80bf\u7624\u533b\u9662\u5f20\u4f1a\u6765\u6559\u6388\uff0c\u91cd\u70b9\u4ecb\u7ecd\u4e86PD-1\u5355\u6297\u5355\u836f\u6cbb\u7597\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\u73b0\u72b6\u53ca\u76f8\u5173\u4e34\u5e8a\u7814\u7a76\uff0c\u5206\u4eab\u4e86\u5bf9\u4e8e\u65b0\u578b\u514d\u75ab\u68c0\u67e5\u70b9\u7684\u63a2\u7d22\u3002<\/p>\n

\u5728\u536b\u661f\u4f1a\u4e2d\uff0c\u5f20\u5f26\u4e3b\u4efb\u5206\u4eab\u4e86\u65b0\u836f\u827e\u6c99\u5eb7\u5511\u5728\u6cbb\u7597R\/R ALL\u53ca\u771f\u83cc\u611f\u67d3\u5e7f\u8c31\u5f3a\u6548\u3001\u5b89\u5168\uff0c\u540c\u65f6\u53ef\u4ee5\u517c\u987e\u672c\u75c5\u6cbb\u7597\u7684\u4f18\u52bf\u3002\u9646\u9053\u57f9\u533b\u9662\u9aa8\u9ad3\u79fb\u690d\u79d1\u5b59\u745e\u5a1f\u4e3b\u4efb\u4ecb\u7ecd\u4e86\u6cca\u9a6c\u5ea6\u80fa\u5728\u767d\u8840\u75c5\u6cbb\u7597\u4e2d\u5e94\u7528\u7684\u4f18\u52bf\u3002<\/p>\n

\u4e3b\u6301\u5609\u5bbe\uff1a\u5362\u5cb3\u4e3b\u4efb\u3001\u4efb\u6c49\u4e91\u6559\u6388\u3001\u9ad8\u6625\u8bb0\u6559\u6388\u3001\u4faf\u5065\u6559\u6388\u6559\u6388\u3001\u97e9\u51b0\u6559\u6388\u3001\u5f20\u6653\u8f89\u6559\u6388\u3001\u9646\u4f69\u534e\u6559\u6388<\/p>\n

\u8840\u6db2\u75c5\u68c0\u9a8c\u4e13\u573a<\/b><\/p>\n

\u7cbe\u51c6\u8bca\u65ad\u8f85\u52a9\u7cbe\u51c6\u6cbb\u7597<\/b><\/p>\n

\u5bf9\u4e8e\u8840\u6db2\u80bf\u7624\u800c\u8a00\uff0c\u7cbe\u51c6\u7684\u8bca\u65ad\u80fd\u591f\u4e3a\u4e34\u5e8a\u533b\u751f\u5236\u5b9a\u66f4\u51c6\u786e\u3001\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6848\u63d0\u4f9b\u91cd\u8981\u4f9d\u636e\uff0c\u5bf9\u4e8e\u60a3\u8005\u75be\u75c5\u7684\u9884\u540e\u5224\u65ad\u5177\u6709\u91cd\u8981\u7684\u610f\u4e49\u3002\u9646\u9053\u57f9\u533b\u9662\u75c5\u7406\u4e0e\u68c0\u9a8c\u533b\u5b66\u56e2\u961f\u9664\u4e86\u4e3a\u6211\u9662\u4e34\u5e8a\u7cbe\u51c6\u6cbb\u7597\u4fdd\u9a7e\u62a4\u822a\u5916\uff0c\u8fd8\u4e3a\u5168\u56fd\u767e\u4f59\u5bb6\u533b\u9662\uff08\u4e3b\u8981\u662f\u4e09\u7532\u533b\u9662\uff09\u63d0\u4f9b\u68c0\u6d4b\u652f\u6301\uff0c\u540c\u65f6\u4e5f\u53d6\u5f97\u4e86\u4e30\u7855\u7684\u5b66\u672f\u6210\u679c\u3002<\/p>\n

\u5317\u4eac\u53cb\u8c0a\u533b\u9662\/\u5317\u4eac\u9646\u9053\u57f9\u533b\u9662\u5468\u5c0f\u9e3d\u6559\u6388\u5206\u4eab\u4e86\u5173\u4e8e\u6dcb\u5df4\u9020\u8840\u7ec4\u7ec7\u75be\u75c5\uff08\u4e0d\u542b\u6dcb\u5df4\u7624\uff09\u8bca\u65ad\u4e2d\u6297\u4f53\u7684\u5408\u7406\u9009\u62e9\uff0c\u7ed3\u5408\u5177\u4f53\u75be\u75c5\u7c7b\u578b\uff0c\u5f3a\u8c03\u9009\u62e9\u6297\u4f53\u7684\u91cd\u8981\u6027\u3002<\/p>\n

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