{"id":70921,"date":"2022-06-29T09:13:00","date_gmt":"2022-06-29T02:13:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022062909130070921"},"modified":"2022-06-29T22:16:03","modified_gmt":"2022-06-29T14:16:03","slug":"%e7%ae%95%e6%98%9f%e5%ae%a3%e5%b8%83aficamten%e5%9c%a8%e4%b8%ad%e5%9b%bd%e8%8e%b7%e5%be%973%e6%9c%9f%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e7%94%b3%e8%af%b7%e6%89%b9%e5%87%86","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022062909130070921","title":{"rendered":"\u7b95\u661f\u5ba3\u5e03aficamten\u5728\u4e2d\u56fd\u83b7\u5f973\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u6279\u51c6"},"content":{"rendered":"

Aficamten\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u5df2\u7ecf\u83b7\u5f97<\/i>\u6cbb\u7597\u75c7\u72b6\u6027\u6897\u963b\u6027\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u7684\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u8ba4\u5b9a<\/i><\/p>\n

\u4e0a\u6d77<\/span>2022\u5e746\u670829\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u7b95\u661f\u836f\u4e1a\uff08\u4e0b\u6587\u7b80\u79f0 "\u7b95\u661f" \uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u4e3a\u7f79\u60a3\u4e25\u91cd\u5371\u53ca\u751f\u547d\u5065\u5eb7\u75be\u75c5\u7684\u60a3\u8005\u63d0\u4f9b\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u5df2\u6279\u51c6aficamten\uff08CK-3773274\u7247\uff09\u5728\u4e2d\u56fd\u6cbb\u7597\u75c7\u72b6\u6027\u6897\u963b\u6027\u80a5\u539a\u578b\u5fc3\u808c\u75c5\uff08oHCM\uff09\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff0c\u8be5\u8bd5\u9a8c\u662faficamten\u5168\u7403\u591a\u4e2d\u5fc3\u7814\u7a76SEQUOIA-HCM\u7684\u4e00\u90e8\u5206\u3002<\/p>\n

Aficamten\u7531 Cytokinetics\u516c\u53f8\u7814\u53d1\uff0c\u662f\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u80a5\u539a\u578b\u5fc3\u808c\u75c5\uff08HCM\uff09\u7684\u6f5c\u5728\u65b0\u4e00\u4ee3\u5fc3\u808c\u808c\u7403\u86cb\u767d\u6291\u5236\u5242\u3002\u4e4b\u524d\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(FDA)\u548c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5df2\u7ecf\u5206\u522b\u6388\u4e88aficamten\u7528\u4e8e\u6cbb\u7597\u75c7\u72b6\u6027\u6897\u963b\u6027\u80a5\u539a\u578b\u5fc3\u808c\u75c5(oHCM)\u7684\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u8ba4\u5b9a\u3002<\/p>\n

"\u76ee\u524d\u4e2d\u56fd\u5c1a\u65e0\u9488\u5bf9oHCM\u57fa\u7840\u75c5\u7406\u751f\u7406\u5b66\u673a\u5236\u7684\u6cbb\u7597\u836f\u7269\u83b7\u6279\uff0c\u6211\u4eec\u76f8\u4fe1aficamten\u5177\u6709\u663e\u8457\u6539\u5584\u8be5\u75be\u75c5\u6cbb\u7597\u73b0\u72b6\u7684\u6f5c\u529b\uff0c\u7ed9\u60a3\u8005\u5e26\u6765\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5f71\u54cd\u3002"\u7b95\u661f\u5fc3\u8840\u7ba1\u9996\u5e2d\u533b\u5b66\u5b98\u674e\u5a9b\u535a\u58eb\u8bf4\uff0c"\u6211\u4eec\u671f\u5f85\u7740\u4e0eCytokinetics\u5408\u4f5c\u5f00\u5c55\u5168\u74033\u671f\u4e34\u5e8a\u8bd5\u9a8cSEQUOIA-HCM\uff0c\u5c3d\u65e9\u5c06aficamten\u8fd9\u4e00\u6f5c\u5728\u65b0\u836f\u5e26\u7ed9\u4e2d\u56fd\u60a3\u8005\u3002"<\/p>\n

SEQUOIA-HCM\u662f\u4e00\u9879\u5728oHCM\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u53cc\u76f2\u7684\u5168\u7403\u591a\u4e2d\u5fc33\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30aficamten\u5728\u4e3a\u671f24\u5468\u6cbb\u7597\u4e2d\u7684\u7597\u6548\u3002SEQUOIA-HCM \u9884\u8ba1\u5c06\u5165\u7ec4\u5305\u62ec\u4e2d\u56fd\u60a3\u8005\u5728\u5185\u7684\u5171270 \u540d\u60a3\u8005\u3002<\/p>\n

\u5173\u4e8e\u80a5\u539a\u578b\u5fc3\u808c\u75c5<\/b>(HCM)<\/b><\/p>\n

\u80a5\u539a\u578b\u5fc3\u808c\u75c5\uff08HCM\uff09\u662f\u6700\u5e38\u89c1\u7684\u9057\u4f20\u6027\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u4e2d\u56fd\u60a3\u75c5\u7387\u4e3a80\/10\u4e07\uff0c\u4f30\u7b97\u4e2d\u56fd\u6210\u4ebaHCM\u60a3\u8005\u8d85\u8fc7100\u4e07\u3002HCM\u53ef\u5bfc\u81f4\u52b3\u529b\u6027\u547c\u5438\u56f0\u96be\u3001\u75b2\u52b3\u3001\u80f8\u75db\u3001\u6655\u53a5\/\u5148\u5146\u6655\u53a5\u548c\u8fd0\u52a8\u80fd\u529b\u53d7\u9650\u3002\u4e0e\u75be\u75c5\u76f8\u5173\u7684\u6b7b\u4ea1\u7387\u5927\u591a\u53ef\u5f52\u56e0\u4e8e\u5fc3\u6e90\u6027\u731d\u6b7b\u3001\u5fc3\u529b\u8870\u7aed\u548c\u6813\u585e\u6027\u5352\u4e2d\u3002HCM\u662f\u9752\u5c11\u5e74\u548c\u8fd0\u52a8\u5458\u731d\u6b7b\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u3002\u5fc3\u810f\u6027\u731d\u6b7b\u5e38\u89c1\u4e8e10\uff5e35\u5c81\u7684\u5e74\u8f7b\u60a3\u8005\uff0c\u5fc3\u529b\u8870\u7aed\u6b7b\u4ea1\u591a\u53d1\u751f\u4e8e\u4e2d\u5e74\u60a3\u8005\uff0cHCM\u76f8\u5173\u7684\u5fc3\u623f\u98a4\u52a8\u5bfc\u81f4\u7684\u5352\u4e2d\u5219\u4ee5\u8001\u5e74\u60a3\u8005\u591a\u89c1\u3002\u5728\u4e09\u7ea7\u533b\u7597\u4e2d\u5fc3\u5c31\u8bca\u7684HCM\u60a3\u8005\u5e74\u6b7b\u4ea1\u7387\u4e3a2%\uff5e4%\u3002<\/p>\n

\u76ee\u524d\u5728\u4e2d\u56fd\u5c1a\u672a\u6709\u76f4\u63a5\u9488\u5bf9HCM\u7684\u83b7\u6279\u836f\u7269\uff0c\u6307\u5357\u63a8\u8350\u7684\u836f\u7269\u6cbb\u7597\u662f\u5728\u7ecf\u9a8c\u6cbb\u7597\u7684\u57fa\u7840\u4e0a\u8fdb\u884c\u63a8\u8350\u7684\uff0c\u4e3b\u8981\u5305\u62ec\u03b2\u53d7\u4f53\u963b\u6ede\u5242\u3001\u7ef4\u62c9\u5e15\u7c73\u3001\u5730\u5c14\u786b\u5353\u548c\u4e19\u5421\u80fa\uff0c\u7136\u800c\uff0c\u8fd9\u4e9b\u836f\u7269\u539f\u672c\u7528\u4e8e\u5176\u4ed6\u75be\u75c5\uff0c\u5e76\u975e\u9488\u5bf9HCM\u7684\u6839\u672c\u75c5\u7406\u673a\u5236\u5373\u5fc3\u808c\u8fc7\u5ea6\u6536\u7f29\uff0c\u901a\u5e38\u4e5f\u4e0d\u80fd\u963b\u6b62\u75be\u75c5\u8fdb\u5c55\uff0c\u4e14\u6709\u660e\u663e\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u4e19\u5421\u80fa\u4e5f\u5c1a\u672a\u5728\u4e2d\u56fd\u4e0a\u5e02\u3002\u5bf9\u4e8e\u90a3\u4e9b\u65e0\u8bba\u9759\u606f\u8fd8\u662f\u6fc0\u53d1\u65f6LVOT-G \u2265 50mmHg\uff0c \u4f34\u6709\u4e25\u91cd\u75c7\u72b6\u4e14\u836f\u7269\u6cbb\u7597\u65e0\u6548\u7684oHCM\u60a3\u8005\uff0c\u5ba4\u95f4\u9694\u6d88\u51cf\u6cbb\u7597\uff08\u5982\u5ba4\u95f4\u9694\u5fc3\u808c\u5207\u9664\u672f\u548c\u7ecf\u76ae\u5ba4\u95f4\u9694\u9152\u7cbe\u6d88\u878d\u672f\uff09\u53ef\u80fd\u662f\u6709\u6548\u7684\uff0c\u7136\u800c\uff0c\u8fd9\u4e9b\u4fb5\u5165\u5f0f\u624b\u672f\u65e0\u6cd5\u5728\u4e2d\u56fd\u5f97\u5230\u5e7f\u6cdb\u5e94\u7528\uff0c\u4e14\u5b58\u5728\u5305\u62ec\u6b7b\u4ea1\u5728\u5185\u7684\u98ce\u9669\u3002\u5ba4\u95f4\u9694\u6d88\u51cf\u6cbb\u7597\u53ca\u5176\u6210\u529f\u53d6\u51b3\u4e8e\u624b\u672f\u8005\u7684\u7ecf\u9a8c\u3002\u603b\u4e4b\uff0c\u76ee\u524d\u53ef\u7528\u7684\u6cbb\u7597\u65b9\u6cd5\u5747\u4e0d\u80fd\u76f4\u63a5\u89e3\u51b3\u75be\u75c5\u7684\u6839\u672c\u539f\u56e0\uff0c\u5373\u5fc3\u808c\u8fc7\u5ea6\u6536\u7f29\u3002<\/p>\n

\u5173\u4e8e<\/b>aficamten <\/b><\/p>\n

Aficamten \u662f\u4e00\u4e2a\u5728\u7814\u7684\u9009\u62e9\u6027\u5c0f\u5206\u5b50\u5fc3\u808c\u808c\u7403\u86cb\u767d\u6291\u5236\u5242\uff0c\u901a\u8fc7\u5168\u9762\u7684\u5316\u5b66\u4f18\u5316\u6765\u6539\u5584\u836f\u7269\u6cbb\u7597\u6307\u6570\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\uff0caficamten\u53ef\u6210\u4e3a\u6f5c\u5728\u7684\u65b0\u4e00\u4ee3\u5fc3\u808c\u808c\u7403\u86cb\u767d\u6291\u5236\u5242\u3002Aficamten\u51cf\u5c11\u6bcf\u4e2a\u5fc3\u52a8\u5468\u671f\u4e2d\u6d3b\u6027\u808c\u7403\u86cb\u767d\u4ea7\u529b\u6a2a\u6865\u7684\u6570\u91cf\uff0c\u4ece\u800c\u6291\u5236\u4e0e\u80a5\u539a\u578b\u5fc3\u808c\u75c5 (HCM) \u76f8\u5173\u7684\u5fc3\u808c\u8fc7\u5ea6\u6536\u7f29\u3002\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0caficamten\u901a\u8fc7\u76f4\u63a5\u4e0e\u5fc3\u808c\u808c\u7403\u86cb\u767d\u5728\u4e00\u4e2a\u72ec\u7279\u548c\u9009\u62e9\u6027\u7684\u53d8\u6784\u7ed3\u5408\u4f4d\u70b9\u7ed3\u5408\uff0c\u6765\u964d\u4f4e\u5fc3\u808c\u6536\u7f29\u529b\uff0c\u4ece\u800c\u963b\u6b62\u808c\u7403\u86cb\u767d\u8fdb\u5165\u6536\u7f29\u72b6\u6001\u3002Aficamten\u7684\u65b0\u836f\u5f00\u53d1\u9879\u76ee\u65e8\u5728\u8bc4\u4f30\u5176\u5728HCM\u60a3\u8005\u4e2d\u63d0\u9ad8\u8fd0\u52a8\u80fd\u529b\u3001\u7f13\u89e3\u75be\u75c5\u75c7\u72b6\uff0c\u4ee5\u53ca\u5bf9\u5fc3\u810f\u7ed3\u6784\u548c\u529f\u80fd\u957f\u671f\u5f71\u54cd\u7684\u6cbb\u7597<\/span>\u6f5c\u529b\u3002<\/p>\n

2020\u5e747\u6708\uff0c\u7b95\u661f\u4e0eCytokinetics, Incorporated\uff08\u4e00\u5bb6\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u52a0\u5dde\u7684\u5904\u4e8e\u65b0\u836f\u7814\u53d1\u540e\u671f\u9636\u6bb5\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff09\u7b7e\u8ba2\u8bb8\u53ef\u5408\u4f5c\u534f\u8bae\u3002\u6839\u636e\u534f\u8bae\uff0cCytokinetics\u6388\u4e88\u7b95\u661f\u5728\u5927\u4e2d\u534e\u5730\u533a\u5f00\u53d1\u548c\u5546\u4e1a\u5316aficamten\uff08\u4e4b\u524d\u79f0\u4e4b\u4e3aCK-274\uff09\u7684\u72ec\u5bb6\u8bb8\u53ef\u30022021\u5e7412\u6708\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(FDA)\u6388\u4e88aficamten\u7528\u4e8e\u6cbb\u7597\u75c7\u72b6\u6027oHCM\u7684\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u8ba4\u5b9a\u30022022\u5e742\u6708\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u6388\u4e88 aficamten\u6cbb\u7597\u75c7\u72b6\u6027oHCM\u7684\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u8ba4\u5b9a\u3002<\/p>\n

\u5173\u4e8e<\/b>SEQUOIA-HCM<\/b><\/p>\n

SEQUOIA-HCM\u662f\u4e00\u9879\u5728oHCM\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u53cc\u76f2\u7684\u5168\u7403\u591a\u4e2d\u5fc33\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30aficamten\u5728\u4e3a\u671f24\u5468\u6cbb\u7597\u4e2d\u7684\u7597\u6548\u3002\u7814\u7a76\u4e3b\u8981\u76ee\u7684\u662f\u901a\u8fc7\u4ece\u57fa\u7ebf\u81f3\u7b2c24\u5468\u5fc3\u80ba\u8fd0\u52a8\u8bd5\u9a8c\uff08CPET\uff09\u6d4b\u5b9a\u7684\u6700\u5927\u6444\u6c27\u91cf\uff08pVO2\uff09\u53d8\u5316\u4ee5\u8bc4\u4ef7aficamten\u5bf9\u75c7\u72b6\u6027oHCM\u60a3\u8005\u8fd0\u52a8\u80fd\u529b\u7684\u5f71\u54cd\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u4ece\u57fa\u7ebf\u81f3\u7b2c12\u5468\u548c\u7b2c24\u5468\u582a\u8428\u65af\u57ce\u5fc3\u808c\u75c5\u8c03\u67e5\u95ee\u5377-\u4e34\u5e8a\u7efc\u5408\u8bc4\u5206\uff08KCCQ­CSS\uff09\u7684\u53d8\u5316\uff0c\u7ebd\u7ea6\u5fc3\u810f\u534f\u4f1a\uff08NYHA\uff09\u5fc3\u529f\u80fd\u5206\u7ea7\u6539\u5584\u22651\u7ea7\u7684\u60a3\u8005\u6bd4\u4f8b\uff0cValsalva\u52a8\u4f5c\u540e\u5de6\u5ba4\u6d41\u51fa\u9053\u538b\u529b\u9636\u5dee\uff08LVOT-G\uff09\u7684\u53d8\u5316\uff0cValsalva\u52a8\u4f5c\u540eLVOT-G<30 mmHg\u7684\u60a3\u8005\u6bd4\u4f8b\u4ee5\u53caCPET\u671f\u95f4\u603b\u5de5\u4f5c\u8d1f\u8377\u7684\u53d8\u5316\u3002SEQUOIA-HCM \u9884\u8ba1\u5c06\u5165\u7ec4270 \u540d\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec\u7ea6 40 \u540d\u4e2d\u56fd\u60a3\u8005\uff0c\u60a3\u8005\u5728\u63a5\u53d7\u6807\u51c6\u6cbb\u7597\u4e4b\u5916\uff0c\u5c06\u4ee51:1\u7684\u6bd4\u4f8b\u968f\u673a\u63a5\u53d7aficamten\u6216\u5b89\u6170\u5242\u6cbb\u7597\u3002<\/p>\n

\u5173\u4e8e\u7b95\u661f<\/b><\/p>\n

\u7b95\u661f\u662f\u4e00\u5bb6\u603b\u90e8\u4f4d\u4e8e\u4e2d\u56fd\u4e0a\u6d77\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u5c06\u521b\u65b0\u79d1\u5b66\u548c\u836f\u7269\u5e26\u7ed9\u7f79\u60a3\u4e25\u91cd\u5371\u53ca\u751f\u547d\u5065\u5eb7\u75be\u75c5\u7684\u4e2d\u56fd\u60a3\u8005\u3002\u7b95\u661f\u7531RTW Investments, LP\u4e8e2019\u5e74\u6295\u8d44\u521b\u7acb\uff0c\u4e0e\u5168\u7403\u591a\u5bb6\u751f\u7269\u6280\u672f\u516c\u53f8\u5f00\u5c55\u5408\u4f5c\uff0c\u901a\u8fc7\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u72ec\u7279\u521b\u65b0\u7684\u6cbb\u7597\u836f\u7269\uff0c\u5e94\u5bf9\u5fc3\u8840\u7ba1\u548c\u773c\u79d1\u75be\u75c5\u9886\u57df\u5c1a\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002\u51ed\u501f\u5f3a\u52b2\u4e14\u4e0d\u65ad\u58ee\u5927\u7684\u4ea7\u54c1\u7ba1\u7ebf\u3001\u7ecf\u9a8c\u4e30\u5bcc\u7684\u7ba1\u7406\u56e2\u961f\u548c\u4ee5\u60a3\u8005\u4e3a\u4e2d\u5fc3\u7684\u7406\u5ff5\uff0c\u7b95\u661f\u5c06\u4e3a\u5927\u4e2d\u534e\u5730\u533a\u7684\u60a3\u8005\u7fa4\u4f53\u5e26\u6765\u6301\u4e45\u800c\u6df1\u8fdc\u7684\u5f71\u54cd\u3002<\/p>\n

\u5173\u4e8e<\/b>Cytokinetics<\/b><\/p>\n

Cytokinetics\u662f\u4e00\u5bb6\u5904\u4e8e\u65b0\u836f\u7814\u53d1\u540e\u671f\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u540c\u7c7b\u9996\u521b\u808c\u8089\u6fc0\u6d3b\u5242\u548c\u65b0\u4e00\u4ee3\u808c\u8089\u6291\u5236\u5242\u7684\u53d1\u73b0\u3001\u5f00\u53d1\u548c\u5546\u4e1a\u5316\uff0c\u4e3a\u808c\u8089\u6027\u80fd\u53d7\u635f\u7684\u8fdb\u884c\u6027\u8870\u5f31\u75be\u75c5\u60a3\u8005\u63d0\u4f9b\u6f5c\u5728\u6cbb\u7597\u9009\u62e9\u3002\u4f5c\u4e3a\u808c\u8089\u751f\u7269\u5b66\u548c\u808c\u8089\u8fd0\u52a8\u529b\u5b66\u9886\u57df\u7684\u9886\u519b\u8005\uff0cCytokinetics\u76ee\u524d\u6b63\u5728\u5f00\u53d1\u5c0f\u5206\u5b50\u5019\u9009\u836f\u7269\uff0c\u6b64\u7c7b\u836f\u7269\u4e13\u95e8\u8bbe\u8ba1\u7528\u4e8e\u5f71\u54cd\u808c\u8089\u7684\u529f\u80fd\u548c\u6536\u7f29\u529b\u3002\u5728\u4e00\u9879\u9488\u5bf9\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u7684\u5927\u578b\u56fd\u96453\u671f\u4e34\u5e8a\u8bd5\u9a8cGALACTIC-HF\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\u540e\uff0cCytokinetics\u5df2\u4e3a\u5176\u65b0\u578b\u5fc3\u808c\u6fc0\u6d3b\u5242omecamtiv mecarbil<\/i>\u7684\u6f5c\u5728\u5546\u4e1a\u5316\u505a\u597d\u51c6\u5907\u3002Cytokinetics \u8fd8\u5728\u5f00\u53d1\u65b0\u4e00\u4ee3\u5fc3\u808c\u808c\u7403\u86cb\u767d\u6291\u5236\u5242aficamten\uff0c\u5f00\u5c55aficamten \u5728\u75c7\u72b6\u6027\u963b\u585e\u6027 HCM\u60a3\u8005\u4e2d\u7684 3 \u671f\u4e34\u5e8a\u8bd5\u9a8cSEQUOIA-HCM\u30022\u671f\u4e34\u5e8a\u8bd5\u9a8cREDWOOD-HCM\u7684\u961f\u52174\u8fd8\u5728\u8bc4\u4f30 aficamten\u5bf9\u975e\u963b\u585e\u6027 HCM \u7684\u6cbb\u7597\u3002Cytokinetics\u8fd8\u62e5\u6709\u53e6\u4e00\u6b3e\u5728\u7814\u836f\u7269reldesemtiv<\/i>\uff0c\u8fd9\u662f\u4e00\u79cd\u5feb\u901f\u9aa8\u9abc\u808c\u808c\u9499\u86cb\u767d\u6fc0\u6d3b\u5242\uff0c\u76ee\u524d\u6b63\u5728\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\uff08ALS\uff09\u60a3\u8005\u4e2d\u8fdb\u884c3\u671f\u4e34\u5e8a\u8bd5\u9a8cCOURAGE-ALS\u3002Cytokinetics\u5ef6\u7eed\u5176\u5728\u808c\u8089\u751f\u7269\u5b66\u53ca\u76f8\u5173\u836f\u7406\u5b66\u9886\u57df20\u591a\u5e74\u6765\u7684\u5f00\u62d3\u521b\u65b0\u5386\u53f2\uff0c\u59cb\u7ec8\u4e13\u6ce8\u4e8e\u808c\u8089\u529f\u80fd\u969c\u788d\u548c\u808c\u65e0\u529b\u75be\u75c5\u3002<\/p>\n

\u5a92\u4f53\u8054\u7edc<\/i><\/p>\n

\u7b95\u661f\u836f\u4e1a
<\/i>media@jixingbio.com<\/a><\/i> <\/p>\n

\n\n\n\n\n\n\n\n
\n

\u53c2\u8003\u6587\u732e<\/i><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e2d\u56fd\u533b<\/i>\u5e08\u534f<\/i>\u4f1a\u5fc3\u529b\u8870\u7aed<\/i>\u4e13\u4e1a<\/i>\u59d4<\/i>\u5458<\/i>\u4f1a<\/i>, <\/i>\u4e2d<\/i>\u534e<\/i>\u5fc3\u529b\u8870\u7aed\u548c\u5fc3\u808c\u75c5<\/i>\u6742<\/i>\u5fd7<\/i>\u7f16\u8f91<\/i>\u59d4<\/i>\u5458<\/i>\u4f1a<\/i>. <\/i>\u4e2d\u56fd\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u7ba1\u7406\u6307\u5357<\/i>2017. <\/i>\u4e2d<\/i>\u534e<\/i>\u5fc3\u529b\u8870\u7aed\u548c\u5fc3\u808c\u75c5<\/i>\u6742<\/i>\u5fd7<\/i>. 2017; 1(2): 65-86.<\/i><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e2d<\/i>\u534e<\/i>\u533b\u5b66\u4f1a\u5fc3\u8840\u7ba1\u75c5\u5b66\u5206\u4f1a\u4e2d\u56fd\u6210\u4eba\u80a5\u539a\u578b\u5fc3\u808c\u75c5<\/i>\u8bca<\/i>\u65ad\u4e0e\u6cbb<\/i>\u7597<\/i>\u6307\u5357<\/i>\u7f16<\/i>\u5199<\/i>\u7ec4<\/i>, <\/i>\u4e2d<\/i>\u534e<\/i>\u5fc3\u8840\u7ba1\u75c5<\/i>\u6742<\/i>\u5fd7<\/i>\u7f16\u8f91<\/i>\u59d4<\/i>\u5458<\/i>\u4f1a<\/i>. <\/i>\u4e2d\u56fd\u6210\u4eba\u80a5\u539a\u578b\u5fc3\u808c\u75c5<\/i>\u8bca<\/i>\u65ad\u4e0e\u6cbb<\/i>\u7597<\/i>\u6307\u5357<\/i>. <\/i>\u4e2d<\/i>\u534e<\/i>\u5fc3\u8840\u7ba1\u75c5<\/i>\u6742<\/i>\u5fd7<\/i>. <\/i>2017;45(12): 1015-1031.<\/i><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Ommen SR et al. 2020 AHA\/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy. Circulation. 2020 Dec 22;142(25):e533-e557.<\/i><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Cytokinetics<\/i>\u5b98\u7f51.<\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Aficamten\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u5df2\u7ecf\u83b7\u5f97\u6cbb\u7597\u75c7\u72b6\u6027\u6897\u963b\u6027\u80a5\u539a\u578b\u5fc3\u808c\u75c5\u7684\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u8ba4\u5b9a \u4e0a\u6d772022\u5e746\u670829\u65e5 \/\u7f8e\u901a\u793e\/ — \u7b95\u661f\u836f\u4e1a\uff08\u4e0b\u6587\u7b80\u79f0 "\u7b95\u661f" 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Cytokinetics\u516c\u53f8\u7814\u53d1\uff0c\u662f\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u80a5\u539a\u578b\u5fc3\u808c\u75c5\uff08HCM\uff09\u7684\u6f5c\u5728\u65b0\u4e00\u4ee3\u5fc3\u808c\u808c\u7403\u86cb\u767d\u6291\u5236\u5242\u3002\u4e4b\u524d\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(FDA)\u548c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5df2\u7ecf\u5206\u522b\u6388\u4e88aficamten\u7528\u4e8e\u6cbb\u7597\u75c7\u72b6\u6027\u6897\u963b\u6027\u80a5\u539a\u578b\u5fc3\u808c\u75c5(oHCM)\u7684\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u8ba4\u5b9a\u3002 "\u76ee\u524d\u4e2d\u56fd\u5c1a\u65e0\u9488\u5bf9oHCM\u57fa\u7840\u75c5\u7406\u751f\u7406\u5b66\u673a\u5236\u7684\u6cbb\u7597\u836f\u7269\u83b7\u6279\uff0c\u6211\u4eec\u76f8\u4fe1aficamten\u5177\u6709\u663e\u8457\u6539\u5584\u8be5\u75be\u75c5\u6cbb\u7597\u73b0\u72b6\u7684\u6f5c\u529b\uff0c\u7ed9\u60a3\u8005\u5e26\u6765\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5f71\u54cd\u3002"\u7b95\u661f\u5fc3\u8840\u7ba1\u9996\u5e2d\u533b\u5b66\u5b98\u674e\u5a9b\u535a\u58eb\u8bf4\uff0c"\u6211\u4eec\u671f\u5f85\u7740\u4e0eCytokinetics\u5408\u4f5c\u5f00\u5c55\u5168\u74033\u671f\u4e34\u5e8a\u8bd5\u9a8cSEQUOIA-HCM\uff0c\u5c3d\u65e9\u5c06aficamten\u8fd9\u4e00\u6f5c\u5728\u65b0\u836f\u5e26\u7ed9\u4e2d\u56fd\u60a3\u8005\u3002" SEQUOIA-HCM\u662f\u4e00\u9879\u5728oHCM\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u53cc\u76f2\u7684\u5168\u7403\u591a\u4e2d\u5fc33\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30aficamten\u5728\u4e3a\u671f24\u5468\u6cbb\u7597\u4e2d\u7684\u7597\u6548\u3002SEQUOIA-HCM \u9884\u8ba1\u5c06\u5165\u7ec4\u5305\u62ec\u4e2d\u56fd\u60a3\u8005\u5728\u5185\u7684\u5171270 \u540d\u60a3\u8005\u3002 \u5173\u4e8e\u80a5\u539a\u578b\u5fc3\u808c\u75c5(HCM) 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