{"id":70687,"date":"2022-06-27T14:16:00","date_gmt":"2022-06-27T07:16:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022062714160070687"},"modified":"2022-06-27T22:42:10","modified_gmt":"2022-06-27T14:42:10","slug":"%e6%ac%a7%e7%8b%84%e6%b2%83r%e5%9c%a8%e4%b8%ad%e5%9b%bd%e5%90%8c%e6%ad%a5%e8%8e%b7%e6%89%b9%e4%b8%a4%e9%a1%b9%e9%a3%9f%e7%ae%a1%e7%99%8c%e9%80%82%e5%ba%94%e7%97%87","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022062714160070687","title":{"rendered":"\u6b27\u72c4\u6c83(R)\u5728\u4e2d\u56fd\u540c\u6b65\u83b7\u6279\u4e24\u9879\u98df\u7ba1\u764c\u9002\u5e94\u75c7"},"content":{"rendered":"<p><p><b>\u5b9e\u73b0\u8fc4\u4eca\u4e3a\u6b62\u56fd\u5185\u83b7\u6279\u4e0a\u6d88\u5316\u9053\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9002\u5e94\u75c7\u7684<\/b><b>&quot;<\/b><b>\u6700\u5168\u8986\u76d6<\/b><b>&quot;<\/b><sup><b><b>[1]<\/b><\/b><\/sup><\/p>\n<ul type=\"disc\">\n<li><i>\u6b27\u72c4\u6c83\uff08\u53ca\u5176\u8054\u5408\u6cbb\u7597\u65b9\u6848\uff09\u662f\u76ee\u524d\u552f\u4e00\u540c\u65f6\u8986\u76d6\u98df\u7ba1\u764c\u8f85\u52a9\u6cbb\u7597\u548c\u665a\u671f\u4e00\u7ebf\u6cbb\u7597\u7684<\/i><i>PD-1<\/i><i>\/PD-L1<\/i><i>\u6291\u5236\u5242\uff1b\u4e14\u5168\u9762\u8986\u76d6\u4e86\u4e0a\u6d88\u5316\u9053\u80bf\u7624\u4e00\u7ebf\u6cbb\u7597\uff08\u65e0\u8bba\u80bf\u7624\u90e8\u4f4d\u4e0e\u7ec4\u7ec7\u5b66\u5206\u578b\uff09\u3002<\/i><\/li>\n<li><i>\u6b27\u72c4\u6c83\u662f\u9996\u4e2a\u4e14\u76ee\u524d\u552f\u4e00\u83b7\u6279\u8f85\u52a9\u6cbb\u7597\u98df\u7ba1\u764c\u7684<\/i><i>PD-1<\/i><i>\/PD-L1<\/i><i>\u6291\u5236\u5242\uff0c\u5bf9\u6bd4\u5b89\u6170\u5242\u7528\u4e8e\u7279\u5b9a\u98df\u7ba1\u764c\u548c\u80c3\u98df\u7ba1\u8fde\u63a5\u90e8\u764c\u60a3\u8005\u7684\u8f85\u52a9\u6cbb\u7597\u53ef\u4f7f\u65e0\u75c5\u751f\u5b58\u671f\uff08<\/i><i>DFS<\/i><i>\uff09\u7ffb\u500d\u3002<\/i><\/li>\n<li><i>\u6b27\u72c4\u6c83\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u98df\u7ba1\u9cde\u764c\uff0c\u5bf9\u6bd4\u5316\u7597\u53ef\u663e\u8457\u6539\u5584\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\uff08<\/i><i>OS<\/i><i>\uff09\uff0c\u5168\u4eba\u7fa4\u83b7\u76ca\uff1b\u4e14\u5728<\/i><i>PD-L1<\/i><i>\u8868\u8fbe\u9633\u6027\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u83b7\u76ca\u66f4\u5927\u7684\u8d8b\u52bf\u3002<\/i><\/li>\n<\/ul>\n<p><span 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type=\"disc\">\n<li>\u7ecf\u65b0\u8f85\u52a9\u653e\u5316\u7597\uff08CRT\uff09\u53ca\u5b8c\u5168\u624b\u672f\u5207\u9664\u540e\u4ecd\u6709\u75c5\u7406\u5b66\u6b8b\u7559\u7684\u98df\u7ba1\u764c\u6216\u80c3\u98df\u7ba1\u8fde\u63a5\u90e8\u764c\u60a3\u8005\u7684\u8f85\u52a9\u6cbb\u7597\uff1b<\/li>\n<li>\u8054\u5408\u6c1f\u5627\u5576\u7c7b\u548c\u542b\u94c2\u5316\u7597\u9002\u7528\u4e8e\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<\/li>\n<\/ul>\n<p>\u6b64\u6b21\u83b7\u6279\uff0c\u6807\u5fd7\u7740<i>\u6b27\u72c4\u6c83<\/i>\u53ca<i>\u6b27\u72c4\u6c83<\/i>\u8054\u5408\u5316\u7597\u6210\u4e3a\u4e86\u4e2d\u56fd\u9996\u4e2a\u4e14\u76ee\u524d\u552f\u4e00\u540c\u65f6\u8986\u76d6\u98df\u7ba1\u764c\u8f85\u52a9\u6cbb\u7597\u4e0e\u665a\u671f\u4e00\u7ebf\u6cbb\u7597\u7684PD-1\/PD-L1\u6291\u5236\u5242\uff1b\u4ee5\u53ca\u9996\u4e2a\u4e14\u76ee\u524d\u552f\u4e00\u8986\u76d6\u4e0a\u6d88\u5316\u9053\u80bf\u7624\u4e00\u7ebf\u6cbb\u7597\u7684PD-1\/PD-L1\u6291\u5236\u5242<sup>[2]<\/sup>\uff08\u65e0\u8bba\u7ec4\u7ec7\u5b66\u5206\u578b\uff08\u9cde\u764c\u3001\u817a\u764c\uff09\u4e0e\u80bf\u7624\u90e8\u4f4d\uff08\u80c3\u3001\u98df\u7ba1\u3001\u80c3\u98df\u7ba1\u8fde\u63a5\u90e8\uff09\uff09\u3002<\/p>\n<p><b>\u524d\u7ebf\u7a81\u7834\u586b\u8865\u7a7a\u767d\uff0c\u5f15\u9886\u514d\u75ab\u8f85\u52a9&quot;\u98df&quot;\u4ee3<\/b><\/p>\n<p><i>\u6b27\u72c4\u6c83<\/i>\u98df\u7ba1\u764c\u8f85\u52a9\u6cbb\u7597\u9002\u5e94\u75c7\u7684\u83b7\u6279\u57fa\u4e8eCheckMate 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id=\"spanHghltdefd\">\u6b27\u72c4\u6c83<\/span><\/i>\u6cbb\u7597\u7684\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\u4e0e\u57fa\u7ebf\u76f8\u6bd4\u4fdd\u6301\u4e0d\u53d8<sup>[4]<\/sup>\u3002&nbsp;<\/p>\n<p>&quot;\u4e2d\u56fd\u662f\u4e16\u754c\u98df\u7ba1\u764c\u7b2c\u4e00\u5927\u56fd\uff0c\u65b0\u589e\u548c\u6b7b\u4ea1\u75c5\u4f8b\u6570\u7684\u5168\u7403\u5360\u6bd4\u5206\u522b\u9ad8\u8fbe53.7%\u548c55.3%<sup>[5]<\/sup>\u3002\u5bf9\u4e8e\u53ef\u624b\u672f\u7684\u5c40\u665a\u671f\u60a3\u8005\uff0c\u540c\u6b65\u653e\u5316\u7597\u662f\u76ee\u524d\u7684\u6807\u51c6\u672f\u524d\u65b0\u8f85\u52a9\u6cbb\u7597\u4e4b\u4e00\uff0c\u4f46\u4ecd\u6709\u7ea670%<sup>[6]&nbsp;<\/sup>\u7684\u60a3\u8005\u65e0\u6cd5\u8fbe\u5230\u75c5\u7406\u5b8c\u5168\u7f13\u89e3\uff0c\u590d\u53d1\u98ce\u9669\u8f83\u9ad8\uff0c\u5c24\u5176\u662f\u53d1\u751f\u8fdc\u5904\u8f6c\u79fb\u7684\u60a3\u8005\uff0c\u540e\u7eed\u6cbb\u7597\u6781\u4e3a\u56f0\u96be\uff1b\u4e14\u8be5\u9886\u57df\u957f\u671f\u4ee5\u6765\u7f3a\u5c11\u88ab\u8bc1\u5b9e\u6709\u6548\u7684\u6807\u51c6\u8f85\u52a9\u6cbb\u7597\u3002&quot; <b>\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662\u80f8\u5916\u79d1\u98df\u7ba1\u75c5\u533a\u4e3b\u4efb\u674e\u5370\u6559\u6388\u8868\u793a<\/b>\uff0c&quot;CheckMate -577\u662f\u514d\u75ab\u6cbb\u7597\u5728\u98df\u7ba1\u764c\u8f85\u52a9\u6cbb\u7597\u4e2d\u7684\u9996\u4e2a\u91cd\u5927\u7a81\u7834\uff0c\u8bc1\u5b9e<i>\u6b27\u72c4\u6c83<\/i>\u53ef\u5ef6\u957f\u60a3\u8005\u4e2d\u4f4dDFS\u81f3\u7ffb\u500d\u3001\u4e2d\u4f4dDMFS\u8fd130\u4e2a\u6708\uff0c\u4e14\u4e0d\u5f71\u54cd\u751f\u6d3b\u8d28\u91cf\uff0c\u5bf9\u6539\u5584\u60a3\u8005\u672f\u540e\u751f\u5b58\u610f\u4e49\u91cd\u5927\u3002\u6b64\u6b21\u83b7\u6279\u586b\u8865\u4e86\u4e34\u5e8a\u7a7a\u767d\uff0c\u6709\u671b\u91cd\u65b0\u5b9a\u4e49\u98df\u7ba1\u764c\u56f4\u624b\u672f\u671f\u6cbb\u7597\u89c4\u8303\uff1b\u4e5f\u575a\u5b9a\u4e86\u6211\u4eec\u5bf9\u4e8e\u514d\u75ab\u6cbb\u7597\u5411\u6d88\u5316\u9053\u80bf\u7624\u66f4\u524d\u7ebf\u63a8\u8fdb\u7684\u4fe1\u5fc3\u3002&quot;<\/p>\n<p>\u57fa\u4e8eCheckMate -577\u7684\u7ed3\u679c\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u5df2\u88ab\u7eb3\u5165\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09<sup>[7]<\/sup>\u3001\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7efc\u5408\u7f51\u7edc\uff08NCCN\uff09<sup>[8]<\/sup>\u7b49\u6743\u5a01\u98df\u7ba1\u764c\u4e34\u5e8a\u8bca\u7597\u6307\u5357\uff0c\u6210\u4e3a\u76ee\u524d\u552f\u4e00\u83b7\u63a8\u8350\u7684\u98df\u7ba1\u764c\u514d\u75ab\u8f85\u52a9\u6cbb\u7597\u836f\u7269\u3002<\/p>\n<p><b>\u4e00\u7ebf\u6cbb\u7597\u5168\u65b0\u9009\u62e9\uff0c\u663e\u8457\u83b7\u76ca\u5f70\u663e&quot;\u98df&quot;\u529b<\/b><\/p>\n<p><i>\u6b27\u72c4\u6c83<\/i>\u8054\u5408\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u98df\u7ba1\u9cde\u764c\u7684\u9002\u5e94\u75c7\u83b7\u6279\u57fa\u4e8eCheckMate -648\u7814\u7a76\u3002CheckMate -648\u662f\u8fc4\u4eca\u5f00\u5c55\u7684\u7eb3\u5165\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u6570\u91cf\u6700\u591a\u7684\u514d\u75ab\u6cbb\u7597III\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30\u4e0e\u5355\u7eaf\u5316\u7597\u76f8\u6bd4\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u8054\u5408\u5316\u7597\uff0c\u6216<i>\u6b27\u72c4\u6c83<\/i>\u8054\u5408CTLA-4\u6291\u5236\u5242<i>\u9038\u6c83<\/i><sup>&reg;<\/sup>\uff08\u4f0a\u5339\u6728\u5355\u6297\uff09\u7528\u4e8e\u665a\u671f\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u3002<\/p>\n<p>\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5728\u6240\u6709\u968f\u673a\u4eba\u7fa4\u4e2d\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5355\u7eaf\u5316\u7597\u53ef\u663e\u8457\u6539\u5584\u60a3\u8005\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3002<i>\u6b27\u72c4\u6c83<\/i>\u8054\u5408\u5316\u7597\u7ec4\u7684\u4e2d\u4f4dOS\u4e3a13.2\u4e2a\u6708\uff0c\u5355\u72ec\u5316\u7597\u7ec4\u4e3a10.7\u4e2a\u6708\u3002<i>\u6b27\u72c4\u6c83<\/i>\u8054\u5408\u5316\u7597\u7ec4\u8fd8\u663e\u793a\u51fa\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u6539\u5584\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u8054\u5408\u5316\u7597\u7ec4\u7684ORR\u4e3a47%\uff0c\u5355\u72ec\u5316\u7597\u7ec4\u4e3a27%<sup>[9]<\/sup>\u3002<\/p>\n<p>\u5728\u80bf\u7624\u8868\u8fbePD-L1 \u2265&nbsp;1%\u7684\u60a3\u8005\u4e2d\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u8054\u5408\u5316\u7597\u89c2\u5bdf\u5230\u83b7\u76ca\u66f4\u5927\u7684\u8d8b\u52bf\uff0c\u4e2d\u4f4dOS\u4e3a15.4\u4e2a\u6708\uff0c\u5bf9\u6bd4\u5355\u7eaf\u5316\u7597\u53ef\u4f7fOS\u5ef6\u957f\u8d856\u4e2a\u6708\uff08\u5316\u7597\u7ec4\u4e3a 9.1\u4e2a\u6708\uff09\uff0c\u964d\u4f4e46%\u6b7b\u4ea1\u98ce\u9669\u3002<i>\u6b27\u72c4\u6c83<\/i>\u8054\u5408\u5316\u7597\u7ec4\u7684ORR\uff0853%\uff09\u8fbe\u5355\u7eaf\u5316\u75972.5\u500d\uff0820%\uff09<sup>[9]<\/sup>\u3002<\/p>\n<p>\u7814\u7a76\u4e2d\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u8054\u5408\u5316\u7597\u672a\u51fa\u73b0\u9884\u671f\u5916\u7684\u5b89\u5168\u4fe1\u53f7\u3002<\/p>\n<p>&quot;\u4e2d\u56fd\u98df\u7ba1\u764c\u60a3\u8005\u4e2d\uff0c\u75c5\u7406\u7c7b\u578b\u4e3a\u9cde\u764c\u7684\u60a3\u8005\u5360\u6bd4\u8fbe90%\u4ee5\u4e0a<sup>[10]<\/sup>\u3002CheckMate \u2013648\u662f\u8fc4\u4eca\u4e3a\u6b62\u5f00\u5c55\u7684\u7eb3\u5165\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u6837\u672c\u6700\u5927\u7684\u514d\u75ab\u6cbb\u7597III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u4e14\u5176\u4e2d\u7684\u4e2d\u56fd\u60a3\u8005\u6570\u91cf\u53ef\u89c2\uff0c\u56e0\u800c\u5176\u7ed3\u679c\u5bf9\u4e8e\u4e2d\u56fd\u665a\u671f\u98df\u7ba1\u9cde\u764c\u7684\u4e00\u7ebf\u8bca\u7597\u5177\u6709\u91cd\u8981\u7684\u53c2\u8003\u610f\u4e49\u3002&quot;<b>\u89e3\u653e\u519b\u603b\u533b\u9662\u7b2c\u4e00\u533b\u5b66\u4e2d\u5fc3\u80bf\u7624\u4e2d\u5fc3\u4e3b\u4efb\u5f90\u5efa\u660e\u6559\u6388\u8868\u793a\uff0c<\/b>&quot;<i>\u6b27\u72c4\u6c83<\/i>\u65b9\u6848\u53ef\u663e\u8457\u6539\u5584\u4e00\u7ebf\u6cbb\u7597\u60a3\u8005OS\uff1b\u4e14\u5728\u6b64\u57fa\u7840\u4e0a\uff0cPD-L1\u9633\u6027\u60a3\u8005\u83b7\u76ca\u8d8b\u52bf\u66f4\u5927\uff0c\u4e2d\u4f4dOS\u7684\u5ef6\u957f\u5e45\u5ea6\u53ef\u8fbe\u534a\u5e74\u4ee5\u4e0a\u3002\u6b64\u6b21\u83b7\u6279\u8fdb\u4e00\u6b65\u4e30\u5bcc\u4e86\u98df\u7ba1\u9cde\u764c\u4e00\u7ebf\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u4e3a\u66f4\u591a\u4e2d\u56fd\u60a3\u8005\u5e26\u6765\u4e86\u6539\u5584\u7597\u6548\u7684\u5e0c\u671b\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u7814\u7a76\u4e2d<i>\u6b27\u72c4\u6c83<\/i>\u8054\u5408CTLA-4\u6291\u5236\u5242<i>\u9038\u6c83<\/i>\u4e5f\u8868\u73b0\u51fa\u663e\u8457\u7684\u7597\u6548\uff0c\u5bf9\u6bd4\u5355\u7eaf\u5316\u7597\u663e\u8457\u6539\u5584\u4e86\u6574\u4f53\u4eba\u7fa4\u4e2d\u4f4dOS\uff0c\u8fd9\u662f\u8be5\u9886\u57df\u9996\u4e2a\u2018\u65e0\u5316\u7597&#8217;\u65b9\u6848\uff0c\u5341\u5206\u671f\u5f85\u80fd\u5c3d\u5feb\u60e0\u53ca\u4e2d\u56fd\u60a3\u8005\u3002&quot;<\/p>\n<p><b>\u4e0a\u6d88\u5316\u9053\u5168\u9762\u8986\u76d6\uff0c\u5f00\u542f&quot;\u80c3&quot;\u6765&quot;\u98df&quot;\u4ee3\u5f81\u7a0b<\/b><\/p>\n<p>\u6b64\u6b21\u83b7\u6279\u540e\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u53ca<i>\u6b27\u72c4\u6c83<\/i>\u8054\u5408\u5316\u7597\u5df2\u5728\u4e2d\u56fd\u83b7\u62794\u9879\u4e0a\u6d88\u5316\u9053\u80bf\u7624\uff08\u5305\u62ec\u98df\u7ba1\u764c\u3001\u80c3\u98df\u7ba1\u8fde\u63a5\u90e8\u764c\u3001\u80c3\u764c\uff09\u9002\u5e94\u75c7<sup>[11]<\/sup>\uff0c\u5728\u6240\u6709PD-1\/PD-L1\u6291\u5236\u5242\u4e2d\u5c45\u9996\u4f4d\u3002<\/p>\n<p>&quot;<i>\u6b27\u72c4\u6c83<\/i>\u6b64\u6b21\u540c\u65f6\u6536\u83b7\u4e24\u5927\u98df\u7ba1\u764c\u9002\u5e94\u75c7\uff0c\u5f70\u663e\u4e86\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u8df5\u884c\u2018\u4e2d\u56fd2030\u6218\u7565&#8217;\u3001\u52a0\u901f\u5f15\u8fdb\u5168\u7403\u521b\u65b0\u4ea7\u54c1\u548c\u9002\u5e94\u75c7\u7684\u51b3\u5fc3\u4e0e\u529b\u5ea6\u3002&quot;&nbsp;<b>\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u4e2d\u56fd\u533a\u603b\u88c1\u9648\u601d\u6e0a\u5973\u58eb<\/b>\u8868\u793a\uff0c&quot;\u5728\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u8fdb\u5165\u4e2d\u56fd\u5927\u964640\u5468\u5e74\u4e4b\u9645\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u53ca\u5176\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5b9e\u73b0\u4e86\u8fc4\u4eca\u4e3a\u6b62\u514d\u75ab\u7597\u6cd5\u5728\u4e0a\u6d88\u5316\u9053\u80bf\u7624\u9886\u57df\u9002\u5e94\u75c7\u7684\u2018\u6700\u5168\u8986\u76d6&#8217;\u3002\u8fd9\u5c55\u73b0\u51fa\u6211\u4eec\u957f\u671f\u6df1\u8015\u4e2d\u56fd\u9ad8\u53d1\u75be\u75c5\u9886\u57df\uff0c\u81f4\u529b\u4e8e\u6ee1\u8db3\u4e2d\u56fd\u60a3\u8005\u7684\u672a\u5c3d\u4e4b\u9700\u3001\u5f15\u9886\u4e0a\u6d88\u5316\u9053\u80bf\u7624\u521b\u65b0\u6cbb\u7597\u7684\u4e0d\u61c8\u52aa\u529b\u3002\u672a\u6765\uff0c\u6211\u4eec\u5c06\u79ef\u6781\u53d1\u6325\u81ea\u8eab\u5728\u8f83\u65e9\u671f\u764c\u75c7\u63a2\u7d22\u4e2d\u7684\u4f18\u52bf\uff0c\u8fdb\u4e00\u6b65\u62d3\u5c55\u514d\u75ab\u6cbb\u7597\u7684\u5e94\u7528\uff1b\u540c\u65f6\u4e0e\u5404\u65b9\u643a\u624b\uff0c\u52aa\u529b\u63d0\u5347\u521b\u65b0\u836f\u7269\u53ef\u53ca\u6027\uff0c\u6539\u53d8\u60a3\u8005\u751f\u547d\u3002&quot;<\/p>\n<p>\u81ea2018\u5e74<i>\u6b27\u72c4\u6c83<\/i>\u6210\u4e3a\u4e2d\u56fd\u9996\u4e2a\u83b7\u6279\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u836f\u7269\u4ee5\u6765\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u59cb\u7ec8\u9ad8\u5ea6\u5173\u6ce8\u4e2d\u56fd\u60a3\u8005\u5bf9\u521b\u65b0\u6cbb\u7597\u7684\u53ef\u53ca\u6027\uff0c\u5e76\u4e8e2019\u5e74\u652f\u6301\u4e2d\u56fd\u764c\u75c7\u57fa\u91d1\u4f1a\uff08CFC\uff09\u53d1\u8d77\u4e86<i>\u6b27\u72c4\u6c83<\/i>\u60a3\u8005\u63f4\u52a9\u9879\u76ee\u3002\u4f34\u968f\u6b64\u6b21\u83b7\u6279\uff0c\u4e2d\u56fd\u764c\u75c7\u57fa\u91d1\u4f1a\u5ba3\u5e03\uff0c&quot;<i>\u6b27\u72c4\u6c83<\/i>\u60a3\u8005\u63f4\u52a9\u9879\u76ee&quot; \u5c06\u589e\u52a0\u98df\u7ba1\u764c\u6216\u80c3\u98df\u7ba1\u8fde\u63a5\u90e8\u764c\u8f85\u52a9\u6cbb\u7597\u548c\u4e00\u7ebf\u665a\u671f\u98df\u7ba1\u9cde\u764c\u9002\u5e94\u75c7\uff0c\u60e0\u53ca\u66f4\u591a\u4e2d\u56fd\u764c\u75c7\u60a3\u8005\uff0c\u5e2e\u52a9\u4ed6\u4eec\u83b7\u5f97\u6539\u5584\u6cbb\u7597\u6548\u679c\u7684\u673a\u4f1a\u3002<\/p>\n<p><i>\u6b27\u72c4\u6c83\u8054\u5408\u9038\u6c83\u7528\u4e8e\u98df\u7ba1\u9cde\u764c\u665a\u671f\u4e00\u7ebf\u6cbb\u7597\u5728\u4e2d\u56fd\u5c1a\u672a\u83b7\u6279<\/i><\/p>\n<p><i>\u672c\u8d44\u6599\u4e2d\u6d89\u53ca\u7684\u4fe1\u606f\u4ec5\u4f9b\u53c2\u8003\uff0c\u8bf7\u9075\u4ece\u533b\u751f\u6216\u5176\u4ed6\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u6216\u6307\u5bfc<\/i><i>.<\/i><\/p>\n<div>\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1] \u6839\u636e\u622a\u81f32021\u5e744\u670821\u65e5\u6839\u636e\u516c\u793a\u4fe1\u606f\u7edf\u8ba1\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[2] \u57fa\u4e8eCheckMate -649\u7814\u7a76\uff0c\u6b27\u72c4\u6c83\u5df2\u4e8e2021\u5e74\u83b7\u5f97NMPA\u6279\u51c6\u8054\u5408\u5316\u7597\u7528\u4e8e\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\u3001\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u764c\u6216\u98df\u7ba1\u817a\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[3]&nbsp;Moehler, M et al 2021, Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer following neoadjuvant chemoradiotherapy: 14-month follow-up of CheckMate 577, Poster 1381P, presented at the ESMO Virtual Congress 2021, September 16-21.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[4]&nbsp;Kelly, RJ et al 2021, Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer. N Engl J Med 2021; 384:1191-1203. DOI: 10.1056\/NEJMoa2032125.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[5]&nbsp;Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. Available from: https:\/\/gco.iarc.fr\/today.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[6]&nbsp;Blum MM et al. 2017, Pathological complete response in patients with esophageal cancer after the trimodality approach: the association with baseline variables and survival \u2014 the University of Texas MD Anderson Cancer Center experience. Cancer 2017;123:4106-4113.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[7]&nbsp;\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u6307\u5357\u5de5\u4f5c\u59d4\u5458\u4f1a. \u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u98df\u7ba1\u764c\u8bca\u7597\u6307\u53572021 . \u4eba\u6c11\u536b\u751f\u51fa\u7248\u793e, 2021.4.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[8] National Comprehensive Cancer Network. (2022).&nbsp;<i>Esophageal and Esophagogastric Junction Cancers (version 2.2022)<\/i>. Retrieved from https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/esophageal.pdf.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[9]&nbsp;Doki, Y et al. 2022, Nivolumab Combination Therapy in Advanced Esophageal Squamous-Cell Carcinoma. N Engl J Med 2022; 386:449-62.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[10]&nbsp;\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a. \u98df\u7ba1\u764c\u8bca\u7597\u89c4\u8303(2018\u5e74\u7248) [J\/CD] . \u4e2d\u534e\u6d88\u5316\u75c5\u4e0e\u5f71\u50cf\u6742\u5fd7\uff08\u7535\u5b50\u7248\uff09,2019,9 (4): 158-192.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[11]&nbsp;\u5177\u4f53\u83b7\u6279\u9002\u5e94\u75c7\u8bf7\u53c2\u89c1\u672b\u5c3e&quot;\u5173\u4e8e\u6b27\u72c4\u6c83&quot;\u90e8\u5206\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5b9e\u73b0\u8fc4\u4eca\u4e3a\u6b62\u56fd\u5185\u83b7\u6279\u4e0a\u6d88\u5316\u9053\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9002\u5e94\u75c7\u7684&quot;\u6700\u5168\u8986\u76d6&quot;[1] \u6b27\u72c4\u6c83\uff08\u53ca\u5176\u8054\u5408\u6cbb\u7597\u65b9\u6848\uff09\u662f\u76ee\u524d\u552f\u4e00\u540c\u65f6\u8986\u76d6\u98df\u7ba1\u764c\u8f85\u52a9\u6cbb\u7597\u548c\u665a\u671f\u4e00\u7ebf\u6cbb\u7597\u7684PD-1\/PD-L1\u6291\u5236\u5242\uff1b\u4e14\u5168\u9762\u8986\u76d6\u4e86\u4e0a\u6d88\u5316\u9053\u80bf\u7624\u4e00\u7ebf\u6cbb\u7597\uff08\u65e0\u8bba\u80bf\u7624\u90e8\u4f4d\u4e0e\u7ec4\u7ec7\u5b66\u5206\u578b\uff09\u3002 \u6b27\u72c4\u6c83\u662f\u9996\u4e2a\u4e14\u76ee\u524d\u552f\u4e00\u83b7\u6279\u8f85\u52a9\u6cbb\u7597\u98df\u7ba1\u764c\u7684PD-1\/PD-L1\u6291\u5236\u5242\uff0c\u5bf9\u6bd4\u5b89\u6170\u5242\u7528\u4e8e\u7279\u5b9a\u98df\u7ba1\u764c\u548c\u80c3\u98df\u7ba1\u8fde\u63a5\u90e8\u764c\u60a3\u8005\u7684\u8f85\u52a9\u6cbb\u7597\u53ef\u4f7f\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09\u7ffb\u500d\u3002 \u6b27\u72c4\u6c83\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u98df\u7ba1\u9cde\u764c\uff0c\u5bf9\u6bd4\u5316\u7597\u53ef\u663e\u8457\u6539\u5584\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\uff0c\u5168\u4eba\u7fa4\u83b7\u76ca\uff1b\u4e14\u5728PD-L1\u8868\u8fbe\u9633\u6027\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u83b7\u76ca\u66f4\u5927\u7684\u8d8b\u52bf\u3002 \u4e0a\u6d772022\u5e746\u670827\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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[1] \u6839\u636e\u622a\u81f32021\u5e744\u670821\u65e5\u6839\u636e\u516c\u793a\u4fe1\u606f\u7edf\u8ba1\u3002 [2] \u57fa\u4e8eCheckMate -649\u7814\u7a76\uff0c\u6b27\u72c4\u6c83\u5df2\u4e8e2021\u5e74\u83b7\u5f97NMPA\u6279\u51c6\u8054\u5408\u5316\u7597\u7528\u4e8e\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\u3001\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u764c\u6216\u98df\u7ba1\u817a\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002 [3]&nbsp;Moehler, M et al 2021, Adjuvant nivolumab in resected&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2022062714160070687\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-70687","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/70687","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=70687"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/70687\/revisions"}],"predecessor-version":[{"id":70688,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/70687\/revisions\/70688"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=70687"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=70687"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=70687"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}