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PD-1\/\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53\u914d\u4f531\uff08Programmed Death-Ligand 1, PD-L1\uff09\u901a\u8def\uff0c\u91cd\u65b0\u6fc0\u6d3b\u6dcb\u5df4\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684<sup>6<\/sup>\u3002\u76ee\u524d\u6709\u8d85\u8fc7\u4e8c\u5341\u591a\u4e2a\u4e34\u5e8a\u7814\u7a76\uff08\u5176\u4e2d10\u591a\u9879\u662f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\uff09\u6b63\u5728\u8fdb\u884c\uff0c\u4ee5\u8bc4\u4f30\u4fe1\u8fea\u5229\u5355\u6297\u5728\u5404\u7c7b\u5b9e\u4f53\u80bf\u7624\u548c\u8840\u6db2\u80bf\u7624\u4e0a\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u516d\u9879\u9002\u5e94\u75c7\u5e76\u4e14\u524d\u56db\u9879\u5df2\u6210\u529f\u7eb3\u5165\u4e2d\u56fd\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\uff0c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u7528\u4e8e\u6cbb\u7597\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff1b<\/li>\n<li>\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u5316\u7597\u7528\u4e8eEGFR\u6216ALK\u9634\u6027\u7684\u665a\u671f\u975e\u9cde\u72b6NSCLC\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/li>\n<li>\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u548c\u94c2\u7c7b\u5316\u7597\u9002\u7528\u4e8e\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6NSCLC\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/li>\n<li>\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7528\u4e8e\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/li>\n<li>\u8054\u5408\u987a\u94c2\u548c\u7d2b\u6749\u9187\/\u987a\u94c2\u548c5-\u6c1f\u5c3f\u5627\u5576\u7528\u4e8e\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/li>\n<li>\u8054\u5408\u542b\u6c1f\u5c3f\u5627\u5576\u7c7b\u548c\u94c2\u7c7b\u836f\u7269\u5316\u7597\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<\/li>\n<\/ul>\n<p>\u53e6\u5916\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u53ca\u5316\u7597\u7528\u4e8e\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKI\uff09\u6cbb\u7597\u5931\u8d25\u7684EGFR\u7a81\u53d8\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e0a\u5e02\u7533\u8bf7\u5df2\u83b7\u4e2d\u56fd\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\u5ba1\u8bc4\u3002<\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\u53e6\u6709\u4e24\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u5230\u7814\u7a76\u7ec8\u70b9\uff0c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u5355\u836f\u7528\u4e8e\u665a\u671f\/\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684\u4e8c\u671f\u4e34\u5e8a\u7814\u7a76\uff1b<\/li>\n<li>\u5355\u836f\u7528\u4e8e\u542b\u94c2\u5316\u7597\u5931\u8d25\u7684\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684\u4e09\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/li>\n<\/ul>\n<p><b>\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269\u548c\u793c\u6765\u5236\u836f\u7684\u6218\u7565\u5408\u4f5c<\/b><\/p>\n<p>\u4fe1\u8fbe\u751f\u7269\u4e0e\u793c\u6765\u5236\u836f\u4e8e2015\u5e743\u6708\u8fbe\u6210\u4e86\u4e00\u9879\u751f\u7269\u6280\u672f\u836f\u7269\u5f00\u53d1\u5408\u4f5c\uff0c\u8be5\u5408\u4f5c\u4ea6\u662f\u8fc4\u4eca\u4e3a\u6b62\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4f01\u4e1a\u4e0e\u8de8\u56fd\u836f\u4f01\u4e4b\u95f4\u6700\u5927\u7684\u5408\u4f5c\u4e4b\u4e00\u3002\u6839\u636e\u5408\u4f5c\u6761\u6b3e\uff0c\u4fe1\u8fbe\u751f\u7269\u548c\u793c\u6765\u5236\u836f\u5c06\u5728\u4e2d\u56fd\u5171\u540c\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u5305\u62ec\u8fbe\u4f2f\u8212&reg;\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u5728\u5185\u7684\u80bf\u7624\u836f\u7269\u30022015\u5e7410\u6708\uff0c\u53cc\u65b9\u5ba3\u5e03\u518d\u6b21\u62d3\u5c55\u5df2\u5efa\u7acb\u7684\u836f\u7269\u5f00\u53d1\u5408\u4f5c\uff0c\u589e\u52a0\u4e09\u4e2a\u65b0\u578b\u80bf\u7624\u6cbb\u7597\u6297\u4f53\u30022019\u5e748\u6708\uff0c\u53cc\u65b9\u5408\u4f5c\u6269\u5c55\u81f3\u7cd6\u5c3f\u75c5\u9886\u57df\uff0c\u4fe1\u8fbe\u751f\u7269\u83b7\u6388\u6743\u5728\u4e2d\u56fd\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u793c\u6765\u7684\u4e00\u4e2a\u6f5c\u5728\u5168\u7403\u6700\u4f73\u65b0\u578b\u4e34\u5e8a\u9636\u6bb5\u7cd6\u5c3f\u75c5\u836f\u7269\u3002\u8fd9\u4e09\u6b21\u4e0e\u793c\u6765\u5236\u836f\u7684\u5408\u4f5c\u6807\u5fd7\u7740\u4fe1\u8fbe\u751f\u7269\u5df2\u5efa\u7acb\u8d77\u4e00\u4e2a\u7531\u4e2d\u56fd\u521b\u65b0\u836f\u4f01\u4e0e\u5168\u7403\u5236\u836f\u5de8\u5934\u4e4b\u95f4\u7684\u5168\u9762\u6218\u7565\u5408\u4f5c\uff0c\u5176\u8303\u56f4\u6db5\u76d6\u65b0\u836f\u7814\u53d1\uff0c\u4e34\u5e8a\u7814\u7a76\uff0c\u751f\u4ea7\u8d28\u91cf\u548c\u5e02\u573a\u9500\u552e\u7b49\u30022020\u5e748\u6708\uff0c\u4fe1\u8fbe\u751f\u7269\u4e0e\u793c\u6765\u5236\u836f\u5ba3\u5e03\u5c06\u6269\u5927\u4fe1\u8fea\u5229\u5355\u6297\u7684\u6218\u7565\u5408\u4f5c\uff0c\u4fe1\u8fbe\u751f\u7269\u5c06\u6388\u4e88\u793c\u6765\u4fe1\u8fea\u5229\u5355\u6297\u5728\u4e2d\u56fd\u4ee5\u5916\u5730\u533a\u7684\u72ec\u5bb6\u8bb8\u53ef\uff0c\u793c\u6765\u5c06\u81f4\u529b\u4e8e\u5c06\u4fe1\u8fea\u5229\u5355\u6297\u63a8\u5411\u5317\u7f8e\u3001\u6b27\u6d32\u53ca\u5176\u4ed6\u5730\u533a\u30022022\u5e743\u6708\uff0c\u4fe1\u8fbe\u751f\u7269\u4e0e\u793c\u6765\u5236\u836f\u5ba3\u5e03\u6df1\u5316\u80bf\u7624\u9886\u57df\u6218\u7565\u5408\u4f5c\u3002<\/p>\n<p><b>\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n<p>&quot;\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c&quot;\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u7406\u60f3\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u7684\u521b\u65b0\u836f\u7269\u30022018\u5e7410\u670831\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a01801\u3002<\/p>\n<p>\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u516c\u53f8\u51ed\u501f\u521b\u65b0\u6210\u679c\u548c\u56fd\u9645\u5316\u7684\u8fd0\u8425\u6a21\u5f0f\u5728\u4f17\u591a\u751f\u7269\u5236\u836f\u516c\u53f8\u4e2d\u8131\u9896\u800c\u51fa\u3002\u5efa\u7acb\u8d77\u4e86\u4e00\u6761\u5305\u62ec32\u4e2a\u65b0\u836f\u54c1\u79cd\u7684\u4ea7\u54c1\u94fe\uff0c\u8986\u76d6\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u591a\u4e2a\u75be\u75c5\u9886\u57df\uff0c\u5176\u4e2d7\u4e2a\u54c1\u79cd\u5165\u9009\u56fd\u5bb6&quot;\u91cd\u5927\u65b0\u836f\u521b\u5236&quot;\u4e13\u9879\u3002\u516c\u53f8\u5df2\u6709 7\u4e2a\u4ea7\u54c1\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aTYVYT<sup>&reg;<\/sup>\uff1b\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u6538\u540c<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aBYVASDA <sup>&reg;<\/sup>\uff1b\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u82cf\u7acb\u4fe1<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aSULINNO <sup>&reg;<\/sup>\uff1b\u5229\u59a5\u6614\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u534e<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aHALPRYZA<sup>&reg;<\/sup>; \u4f69\u7c73\u66ff\u5c3c\u7247\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u5766<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aPEMAZYRE<sup>&reg;<\/sup>; \u5965\u96f7\u5df4\u66ff\u5c3c\uff0c\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b<sup>&reg;<\/sup>; \u96f7\u83ab\u897f\u5c24\u5355\u6297\uff0c\u5546\u54c1\u540d\uff1a\u5e0c\u5189\u62e9<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aCYRAMZA<sup>&reg;<\/sup>\uff09\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c3\u4e2a\u54c1\u79cd\u5728NMPA\u5ba1\u8bc4\u4e2d\uff0c3\u4e2a\u54c1\u79cd\u8fdb\u5165III\u671f\u6216\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u8fd8\u670919\u4e2a\u4ea7\u54c1\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u4fe1\u8fbe\u751f\u7269\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u5177\u6709\u56fd\u9645\u5148\u8fdb\u6c34\u5e73\u7684\u9ad8\u7aef\u751f\u7269\u836f\u5f00\u53d1\u3001\u4ea7\u4e1a\u5316\u4eba\u624d\u56e2\u961f\uff0c\u5305\u62ec\u4f17\u591a\u6d77\u5f52\u4e13\u5bb6\uff0c\u5e76\u4e0e\u7f8e\u56fd\u793c\u6765\u5236\u836f\u3001Adimab\u3001Incyte\u3001MD Anderson \u764c\u75c7\u4e2d\u5fc3\u548c\u97e9\u56fdHanmi\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1a<a href=\"http:\/\/www.innoventbio.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.innoventbio.com<\/a>\u6216\u516c\u53f8\u9886\u82f1\u8d26\u53f7www.linkedin.com\/company\/innovent-biologics\/\u3002<\/p>\n<p><b>\u5173\u4e8e\u793c\u6765\u5236\u836f<\/b><\/p>\n<p>\u793c\u6765\u5236\u836f\u662f\u4e00\u5bb6\u4ece\u4e8b\u836f\u54c1\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7684\u5168\u7403\u9886\u5148\u7684\u533b\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u901a\u8fc7\u521b\u65b0\u6539\u5584\u4eba\u7c7b\u5065\u5eb7\u6c34\u5e73\u3002\u793c\u6765\u5236\u836f\u8bde\u751f\u4e8e\u4e00\u4e2a\u591a\u4e16\u7eaa\u4e4b\u524d\uff0c\u4e8e1876\u5e74\u7531\u793c\u6765\u4e0a\u6821\u5728\u7f8e\u56fd\u5370\u7b2c\u5b89\u7eb3\u5dde\u521b\u7acb\uff0c\u516c\u53f8\u521b\u59cb\u4eba\u81f4\u529b\u4e8e\u751f\u4ea7\u9ad8\u8d28\u91cf\u7684\u836f\u54c1\u4ee5\u6ee1\u8db3\u5207\u5b9e\u7684\u533b\u7597\u9700\u6c42\u3002\u4eca\u5929\uff0c\u6211\u4eec\u4ecd\u7136\u6267\u7740\u4e8e\u8fd9\u4e00\u4f7f\u547d\uff0c\u5e76\u57fa\u4e8e\u6b64\u5f00\u5c55\u5de5\u4f5c\u3002\u5728\u5168\u7403\u8303\u56f4\u5185\uff0c\u6211\u4eec\u7684\u5458\u5de5\u59cb\u7ec8\u52aa\u529b\u7814\u53d1\u80fd\u4e3a\u4eba\u7c7b\u751f\u6d3b\u5e26\u6765\u6539\u53d8\u7684\u836f\u7269\uff0c\u5e76\u5c06\u5176\u63d0\u4f9b\u7ed9\u90a3\u4e9b\u5207\u5b9e\u6240\u9700\u7684\u60a3\u8005\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u6211\u4eec\u8fd8\u81f4\u529b\u4e8e\u6539\u5584\u516c\u4f17\u5bf9\u4e8e\u75be\u75c5\u7684\u7406\u89e3\u3001\u5e76\u66f4\u597d\u5730\u5f00\u5c55\u75be\u75c5\u7ba1\u7406\uff0c\u540c\u65f6\u901a\u8fc7\u6295\u8eab\u4e8e\u6148\u5584\u4e8b\u4e1a\u548c\u5fd7\u613f\u8005\u6d3b\u52a8\u56de\u9988\u793e\u4f1a\u3002\u793c\u6765\u672c\u7740&quot;\u690d\u6839\u4e2d\u56fd\uff0c\u9020\u798f\u4e2d\u56fd&quot;\u7684\u7406\u5ff5\uff0c\u7740\u529b\u62d3\u5c55\u5728\u534e\u4e1a\u52a1\uff0c\u5728\u7cd6\u5c3f\u75c5\u3001\u80bf\u7624\u3001\u514d\u75ab\u3001\u75bc\u75db\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7b49\u9886\u57df\u5c45\u9886\u5148\u5730\u4f4d\u3002\u5982\u679c\u9700\u8981\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u793c\u6765\u5236\u836f\u7684\u4fe1\u606f\uff0c\u8bf7\u767b\u5f55\uff1awww.lilly.com\u3002<\/p>\n<p><b>\u4fe1\u8fbe\u751f\u7269\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528&quot;\u9884\u671f&quot;\u3001&quot;\u76f8\u4fe1&quot;\u3001&quot;\u9884\u6d4b&quot;\u3001&quot;\u671f\u671b&quot;\u3001&quot;\u6253\u7b97&quot;\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u5e76\u65e0\u4e49\u52a1\u4e0d\u65ad\u5730\u66f4\u65b0\u8fd9\u4e9b\u9884\u6d4b\u6027\u9648\u8ff0\u3002<\/p>\n<p>\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n<p>\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u96c7\u5458\u4ee3\u7406\u6982\u4e0d\u627f\u62c5&nbsp;(a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7f51\u7ad9\u6240\u8f7d\u524d\u77bb\u6027\u8868\u8ff0\u4e4b\u4efb\u4f55\u4e49\u52a1;\u53ca&nbsp;(b) \u5018\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5b9e\u73b0\u6216\u53d8\u6210\u4e0d\u6b63\u786e\u800c\u5f15\u81f4\u4e4b\u4efb\u4f55\u8d23\u4efb\u3002<\/p>\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<ol type=\"1\">\n<li>Xu J, Jiang H, Pan Y, et al. LBA53 Sintilimab plus chemotherapy (chemo) versus chemo as first-line treatment for advanced gastric or gastroesophageal junction (G\/GEJ) adenocarcinoma (ORIENT-16): First results of a randomized, double-blind, phase III study. Ann Oncol 2021;32:S1331.<\/li>\n<li>Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71(3): 209-249.<\/li>\n<li>Fuchs CS, Shitara K, Di Bartolomeo M, et al. Ramucirumab with cisplatin and fluoropyrimidine as first-line therapy in patients with metastatic gastric or junctional adenocarcinoma (RAINFALL): a double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Oncol. 2019; 20(3): 420-435.<\/li>\n<li>Wang H, Guo W, Hu Y, et al. Superiority of the 8th edition of the TNM staging system for predicting overall survival in gastric cancer: Comparative analysis of the 7th and 8th editions in a monoinstitutional cohort[J]. Molecular and Clinical Oncology, 2018, 9(4): 423-431.<\/li>\n<li>Price TJ, Shapiro JD, Segelov E, Karapetis CS, Pavlakis N, Van Cutsem E, Shah MA, Kang YK, Tebbutt NC. Management of advanced gastric cancer. Expert Rev Gastroenterol Hepatol. 2012 Apr;6(2):199-208; quiz 209. doi: 10.1586\/egh.11.103. PMID: 22375525.<\/li>\n<li>Zhang S, Zhang M, Wu W, et al. Preclinical characterization of Sintilimab, a fully human anti-PD-1 therapeutic monoclonal antibody for cancer[J]. Antibody Therapeutics, 2018, 1(2): 65-73.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u56fd\u65e7\u91d1\u5c71\u548c\u4e2d\u56fd\u82cf\u5dde2022\u5e746\u670827\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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