{"id":69772,"date":"2022-06-16T11:27:00","date_gmt":"2022-06-16T04:27:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022061611270069772"},"modified":"2022-06-16T22:40:51","modified_gmt":"2022-06-16T14:40:51","slug":"sirnaomics%e4%ba%8e%e5%90%8c%e8%a1%8c%e8%af%84%e5%ae%a1%e5%88%8a%e7%89%a9%e3%80%8a%e7%9a%ae%e8%82%a4%e7%97%85%e8%8d%af%e7%89%a9%e6%9d%82%e5%bf%97%e3%80%8b%e5%8f%91%e8%a1%a8%e5%85%ac%e5%8f%b8%e6%a0%b8","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022061611270069772","title":{"rendered":"Sirnaomics\u4e8e\u540c\u884c\u8bc4\u5ba1\u520a\u7269\u300a\u76ae\u80a4\u75c5\u836f\u7269\u6742\u5fd7\u300b\u53d1\u8868\u516c\u53f8\u6838\u5fc3\u4ea7\u54c1STP705\u6cbb\u7597\u6210\u4eba\u539f\u4f4d\u9cde\u72b6\u7ec6\u80de\u76ae\u80a4\u764c\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c"},"content":{"rendered":"

\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u76d6\u745f\u65af\u5821\u5e02\u548c\u4e2d\u56fd\u82cf\u5dde<\/span>2022\u5e746\u670816\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — Sirnaomics Ltd.<\/b>\uff08"Sirnaomics<\/b>"\uff0c\u80a1\u4efd\u4ee3\u53f7\uff1a2257.HK\uff09\uff0c\u662f\u4e00\u5bb6\u884c\u4e1a\u9886\u5148\u7684\u4e13\u6ce8\u4e8e\u63a2\u7d22\u53ca\u5f00\u53d1RNAi\u7597\u6cd5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002Sirnaomics\u5ba3\u5e03STP705\u6cbb\u7597\u539f\u4f4d\u9cde\u72b6\u7ec6\u80de\u76ae\u80a4\u764c\uff08isSCC\uff09IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u7ecf\u540c\u884c\u8bc4\u5ba1\u53d1\u8868\u4e8e2022\u5e745\u6708\u300a\u76ae\u80a4\u75c5\u836f\u7269\u6742\u5fd7\u300b\uff08Journal of Drugs in Dermatology\uff0c"JDD<\/b>"\uff09\u3002\u8be5\u9879\u201cTGF-\u03b21\u548cCOX-2\u57fa\u56e0\u6c89\u9ed8\u7597\u6cd5\u5e94\u7528\u4e8e\u6210\u4eba\u539f\u4f4d\u9cde\u72b6\u7ec6\u80de\u76ae\u80a4\u764c\u4e2d\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u201d\u7684\u7814\u7a76\u8868\u660e\uff0cSTP705\u5728\u6cbb\u7597\u539f\u4f4d\u9cde\u72b6\u7ec6\u80de\u76ae\u80a4\u764c\u60a3\u8005\u65f6\u5c55\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002<\/p>\n

\u8be5\u539f\u521b\u578b\u8bba\u6587\u7684\u4e3b\u8981\u7ed3\u679c\u5c55\u793a\u4e86\u8fd9\u9879\u5355\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5242\u91cf\u9012\u589e\u961f\u5217\u7814\u7a76\uff0c\u6b64\u7814\u7a76\u8bc4\u4f30\u4e0d\u540c\u5242\u91cf\u7684STP705\u76ae\u5185\u8f93\u6ce8\u6cbb\u7597\u539f\u4f4d\u9cde\u72b6\u7ec6\u80de\u76ae\u80a4\u764c\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002STP705\u662f\u4e00\u79cdTGF-\u03b21\u548cCOX-2\u8054\u5408\u7ec4\u6c28\u9178 \u2014 \u8d56\u6c28\u9178\u591a\u80bd\uff08siRNA\/HKP\uff09\u7eb3\u7c73\u7c92\u5b50\u57fa\u56e0\u6c89\u9ed8\u7597\u6cd5\u3002\u4e3b\u8981\u7ec8\u70b9\u4e3a\u83b7\u5f97\u5b8c\u5168\u7ec4\u7ec7\u5b66\u6e05\u9664\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\u300225\u540d\u53d7\u8bd5\u8005\u6ce8\u5c04\u4e86\u4e0d\u540c\u5242\u91cf\u7684STP705\uff0c\u5176\u4e2d19\u540d\u53d7\u8bd5\u8005\uff0876%\uff09\u8fbe\u5230\u4e86\u7ec4\u7ec7\u5b66\u6e05\u9664\u3002\u572830\u03bcg\u6cbb\u7597\u7ec4\u548c60\u03bcg\u6cbb\u7597\u7ec4\u4e2d\uff0c\u7ec4\u7ec7\u5b66\u6e05\u9664\u7387\u5206\u522b\u8fbe\u5230\u4e8680%\u548c100%\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0cSTP705\u662f\u76ee\u524d\u6cbb\u7597\u539f\u4f4d\u9cde\u72b6\u7ec6\u80de\u76ae\u80a4\u764c\u4e2d\u8f83\u4e3a\u65e0\u521b\u4e14\u5b89\u5168\u6709\u6548\u7684\u3002\u5176\u5efa\u8bae\u672a\u6765\u7814\u7a76\u5242\u91cf\u4e3a30\u03bcg\/\u6b21\u548c60\u03bcg\/\u6b21\u3002<\/p>\n

\u53bb\u5e74\u4e3e\u884c\u76842021\u5e74\u79cb\u5b63\u4e34\u5e8a\u76ae\u80a4\u75c5\u5b66\u4f1a\u8bae\u4e0a\uff0c\u8fc8\u963f\u5bc6\u5927\u5b66\u7c73\u52d2\u533b\u5b66\u9662\u76ae\u80a4\u75c5\u5b66\u6559\u6388\u3001\u7f8e\u56fd\u76ae\u80a4\u75c5\u5b66\u4f1a\u8463\u4e8b\u4f1a\u6210\u5458\u3001STP705\u7528\u4ee5\u6cbb\u7597isSCC\u4e34\u5e8a\u7814\u7a76\u9996\u5e2d\u7814\u7a76\u5458Brian Berman\u535a\u58eb\u5c31STP705\u7684\u4e34\u5e8a\u5f00\u53d1\u4e0e\u8bd5\u9a8c\u7ed3\u679c\u7684\u7ec6\u8282\u8fdb\u884c\u6c47\u62a5\u6f14\u8bb2\u3002\u6f14\u8bb2\u7ed3\u675f\u540e\u5bf9\u73b0\u573a2000\u591a\u540d\u4e0e\u4f1a\u8005\u8fdb\u884c\u73b0\u573a\u8c03\u67e5\uff0c\u4ee5\u9a8c\u8bc1STP705\u6cbb\u7597isSCC\u662f\u5426\u6ee1\u8db3\u4e34\u5e8a\u5b9e\u8df5\u7684\u533b\u7597\u9700\u6c42\uff0c\u5e76\u4e14\u662f\u5426\u6709\u610f\u613f\u4f7f\u7528\u8fd9\u4e00\u521b\u65b0\u836f\u3002\u8c03\u67e5\u7ed3\u679c\u663e\u793a\uff0c\u73b0\u573a\u4e0e\u4f1a\u76ae\u80a4\u75c5\u533b\u5e08\u5bf9\u4e8eSTP705\u7684\u4e34\u5e8a\u5e94\u7528\u7ed9\u4e88\u6ee1\u5206\u7684\u8bc4\u4ef7\u3002\u5728\u540c\u4e00\u4f1a\u8bae\u671f\u95f4\u63a8\u52a8\u7684Gore Range Capital\u76ae\u80a4\u5065\u5eb7\u521b\u65b0\u5927\u8d5b\uff08Skin Health Innovation Competition\uff09\u4e2d\uff0cSirnaomics\u7684STP705\u88ab\u8bc4\u4e3a\u4e09\u4e2a\u4f18\u9009\u9879\u76ee\u4e4b\u4e00\u3002<\/p>\n

\u201c\u76ee\u524d\u7ecf\u6279\u51c6\u7684\u975e\u624b\u672f\u7684isSCC\u6cbb\u7597\u65b9\u6cd5\u6570\u91cf\u6709\u9650\u3002\u7ecf\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cSTP705\u6709\u53ef\u80fd\u6210\u4e3a\u4e00\u79cd\u53ef\u884c\u7684\u6cbb\u7597\u9009\u62e9\u5bf9\u4e8e\u975e\u624b\u672f\u578b\u7684\u975e\u9ed1\u8272\u7d20\u7624\u76ae\u80a4\u764c\u60a3\u8005\uff0c\u520a\u7269\u4e0e\u8c03\u67e5\u7ed3\u679c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u8be5\u65b0\u578bsiRNA\u7597\u6cd5\u7684\u4e34\u5e8a\u5e94\u7528\u6f5c\u529b\u3002\u201dSirnaomics\u6267\u884c\u8463\u4e8b\u517c\u9996\u5e2d\u533b\u52a1\u5b98Michael Molyneaux\u535a\u58eb\u8bf4\u9053\uff0c\u201cTGF-\u03b21\u548cCOX-2\u8fc7\u5ea6\u7684\u57fa\u56e0\u8868\u8fbe\u4e0eSCC\u7684\u53d1\u5c55\u5bc6\u5207\u76f8\u5173\uff0c\u5176\u4e2dTGF-\u03b21\u5728\u80bf\u7624\u53d1\u5c55\u7684\u8fc7\u7a0b\u4e2d\u5177\u6709\u91cd\u8981\u7684\u4f5c\u7528\u3002\u800c\u901a\u8fc7\u57fa\u4e8eRNAi\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u4f8b\u5982\u4f7f\u7528STP705\uff0c\u53ef\u4ee5\u4f7f\u8fd9\u4e9b\u57fa\u56e0\u6c89\u9ed8\uff0c\u6211\u4eec\u6709\u53ef\u80fd\u901a\u8fc7\u8be5\u975e\u4fb5\u5165\u6027\u7684\u6cbb\u7597\u65b9\u6cd5\u963b\u6b62isSCC\u7684\u589e\u6b96\u3002\u672c\u6b21\u7814\u7a76\u5bf9\u8be5\u8bba\u70b9\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u652f\u6301\uff0c\u6211\u4eec\u8ba1\u5212\u5728\u672a\u6765\u7684\u7814\u7a76\u4e2d\u7ee7\u7eed\u8bc4\u4f3030\u03bcg\u548c60\u03bcg\u7684\u5242\u91cf\u3002\u201d<\/p>\n

Sirnaomics\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u4f1a\u4e3b\u5e2d\u3001\u6267\u884c\u8463\u4e8b\u3001\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98\u9646\u9633\u535a\u58eb\u8868\u793a\uff1a\u201c\u516c\u53f8\u5019\u9009\u4ea7\u54c1STP705\u9002\u7528\u4e8e\u6cbb\u7597isSCC\u7684IIa\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u4e8e\u4ee5\u4e34\u5e8a\u4e3a\u6838\u5fc3\u7684\u520a\u7269\u7ecf\u540c\u884c\u8bc4\u5ba1\u53d1\u8868\uff0c\u52a0\u4e4b\u4e34\u5e8a\u76ae\u80a4\u79d1\u533b\u751f\u79ef\u6781\u6b63\u9762\u7684\u53cd\u9988\uff0c\u8fdb\u4e00\u6b65\u589e\u5f3a\u4e86\u6211\u4eec\u63a8\u8fdbSTP705\u5e94\u7528\u4e8e\u6cbb\u7597\u5404\u79cd\u7c7b\u578b\u7684\u975e\u9ed1\u8272\u7d20\u7624\u4e34\u5e8a\u7814\u7a76\u7684\u4fe1\u5fc3\u3002\u8fd9\u7c7b\u6d41\u884c\u6027\u764c\u75c7\u6bcf\u5e74\u5728\u7f8e\u56fd\u6709\u903e500\u4e07\u65b0\u589e\u75c5\u4f8b\uff0c\u5916\u79d1\u624b\u672f\u5207\u9664\u60a3\u8005\u7684\u80bf\u7624\u8fdb\u5c55\u3001\u8f6c\u79fb\u548c\u590d\u53d1\u7684\u98ce\u9669\u4f1a\u6709\u6240\u589e\u52a0\uff0c\u4e14\u540c\u65f6\u6709\u611f\u67d3\u3001\u8840\u80bf\u6216\u7559\u4e0b\u75a4\u75d5\u7684\u98ce\u9669\u3002\u8fd9\u4e9b\u60a3\u8005\u9700\u8981\u4e00\u79cd\u5177\u6709\u66ff\u4ee3\u6027\u548c\u975e\u4fb5\u5165\u6027\u7684\u6cbb\u7597\u65b9\u6848\u3002\u8fd9\u5c31\u662f\u6211\u4eec\u63a8\u52a8\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc4\u9274STP705\u5de8\u5927\u5e94\u7528\u524d\u666f\u7684\u539f\u56e0\u3002\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u76d6\u745f\u65af\u5821\u5e02\u548c\u4e2d\u56fd\u82cf\u5dde2022\u5e746\u670816\u65e5 \/\u7f8e\u901a\u793e\/ — Sirnaomics Ltd.\uff08"Sirnaomics"\uff0c\u80a1\u4efd\u4ee3\u53f7\uff1a2257.HK\uff09\uff0c\u662f\u4e00\u5bb6\u884c\u4e1a\u9886\u5148\u7684\u4e13\u6ce8\u4e8e\u63a2\u7d22\u53ca\u5f00\u53d1RNAi\u7597\u6cd5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002Sirnaomics\u5ba3\u5e03STP705\u6cbb\u7597\u539f\u4f4d\u9cde\u72b6\u7ec6\u80de\u76ae\u80a4\u764c\uff08isSCC\uff09IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u7ecf\u540c\u884c\u8bc4\u5ba1\u53d1\u8868\u4e8e2022\u5e745\u6708\u300a\u76ae\u80a4\u75c5\u836f\u7269\u6742\u5fd7\u300b\uff08Journal of Drugs in Dermatology\uff0c"JDD"\uff09\u3002\u8be5\u9879\u201cTGF-\u03b21\u548cCOX-2\u57fa\u56e0\u6c89\u9ed8\u7597\u6cd5\u5e94\u7528\u4e8e\u6210\u4eba\u539f\u4f4d\u9cde\u72b6\u7ec6\u80de\u76ae\u80a4\u764c\u4e2d\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u201d\u7684\u7814\u7a76\u8868\u660e\uff0cSTP705\u5728\u6cbb\u7597\u539f\u4f4d\u9cde\u72b6\u7ec6\u80de\u76ae\u80a4\u764c\u60a3\u8005\u65f6\u5c55\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002 \u8be5\u539f\u521b\u578b\u8bba\u6587\u7684\u4e3b\u8981\u7ed3\u679c\u5c55\u793a\u4e86\u8fd9\u9879\u5355\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5242\u91cf\u9012\u589e\u961f\u5217\u7814\u7a76\uff0c\u6b64\u7814\u7a76\u8bc4\u4f30\u4e0d\u540c\u5242\u91cf\u7684STP705\u76ae\u5185\u8f93\u6ce8\u6cbb\u7597\u539f\u4f4d\u9cde\u72b6\u7ec6\u80de\u76ae\u80a4\u764c\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002STP705\u662f\u4e00\u79cdTGF-\u03b21\u548cCOX-2\u8054\u5408\u7ec4\u6c28\u9178 \u2014 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