{"id":69554,"date":"2022-06-14T08:00:00","date_gmt":"2022-06-14T01:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022061408000069554"},"modified":"2022-06-14T22:05:01","modified_gmt":"2022-06-14T14:05:01","slug":"%e4%b9%b3%e8%85%ba%e7%99%8c%e5%a4%9a%e5%9f%ba%e5%9b%a0%e6%a3%80%e6%b5%8bendopredict%ef%bc%8c%e4%b8%ba%e4%b9%b3%e8%85%ba%e7%99%8c%e9%a2%84%e5%90%8e%e8%af%84%e4%bc%b0%e6%96%b0%e8%a7%86%e8%a7%92","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022061408000069554","title":{"rendered":"\u4e73\u817a\u764c\u591a\u57fa\u56e0\u68c0\u6d4bEndoPredict\uff0c\u4e3a\u4e73\u817a\u764c\u9884\u540e\u8bc4\u4f30\u65b0\u89c6\u89d2"},"content":{"rendered":"

Ki-67\u51b3\u5b9a\u5316\u7597\u5fc5\u8981\u6027\uff1fKi-67\u4e0e\u9884\u540e\u7684\u5173\u7cfb<\/p>\n

\u6e56\u5dde<\/span>2022\u5e746\u670813\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u8fd1\u671f\uff0c<\/span>\u7531\u6570\u95ee\u751f\u7269\u72ec\u5bb6\u5f15\u8fdb\u7684EndoPredict\uff08\u95ee\u8c31\u7279\u3001EPclin\u300112\u57fa\u56e0\uff09\u7cbe\u51c6\u8bc4\u4f30\u60a3\u8005\u8fdc\u671f\u9884\u540e\uff0c\u7acb\u8db3\u4e8e\u57fa\u56e0\u8bc4\u4f30\uff0c\u7740\u773c\u4e8e\u4e34\u5e8a\u56e0\u7d20\uff0c\u4e3a\u4e73\u817a\u764c\u9884\u540e\u8bc4\u4f30\u63d0\u4f9b\u65b0\u89c6\u89d2\uff0c\u52a9\u529b\u4e73\u817a\u764c\u4e2a\u4f53\u5316\u8bca\u7597\u65b0\u7bc7\u7ae0\u3002<\/p>\n

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\u6709\u4e00\u9879\u7814\u7a76\u9488\u5bf9Ki-67\u8868\u8fbe\u5f3a\u5ea6\u4e0e\u4e73\u817a\u764c\u8fdc\u5904\u590d\u53d1\u98ce\u9669\u7684\u5173\u7cfb\u8fdb\u884c\u4e86\u5206\u6790\u30022020\u5e74\u5723\u5b89\u4e1c\u5c3c\u5965\u56fd\u9645\u4e73\u817a\u764c\u4f1a\u8bae\uff08SABCS\uff09\u4e0a\u53d1\u5e03\u4e86\u4e00\u9879\u5728\u771f\u5b9e\u4e16\u754c\u4e2d\u4e0e\u4e34\u5e8a\u6307\u6807\u5bf9\u6bd4\u5206\u6790\u7684\u6458\u8981\u7814\u7a76\u3010<\/sup>2<\/sup>\u3011<\/sup>\u3002\u8be5\u7814\u7a76\u56de\u987e\u6027\u5206\u6790\u4e86\u4ece2017-2020\u5e74\u671f\u95f4\u5728\u4e34\u5e8a\u8bca\u7597\u4e2d\u8fdb\u884c\u8fc7EndoPredict\uff08EPclin\u300112\u57fa\u56e0\uff09\u68c0\u6d4b\u76841652\u4f8bER\u9633\u6027\u3001HER2\u9634\u6027\u65e9\u671f\u4e73\u817a\u764c\u6837\u672c\uff0c\u5206\u522b\u4eceKi-67\u3001EPclin\u8bc4\u5206\u533a\u5206\u7684\u4e9a\u7ec4\u8fdb\u884c\u5206\u6790\u3002<\/p>\n

\u7ed3\u679c\u663e\u793a\uff1a<\/p>\n

    \n
  1. \u57281652\u4f8b\u60a3\u8005\u4e2d\uff0cEPclin\u8bc4\u5206\u533a\u5206\u51fa1026\u4f8b\u9ad8\u5371\u60a3\u8005\uff0c\u5360\u6bd462.1%\uff1b<\/li>\n
  2. Ki-67\u4f4e\u8868\u8fbe\u7ec4\uff08Ki-67\u5927\u4e8e\u7b49\u4e8e<\/span>20%\uff09\u5171\u5305\u542b1203\u4f8b\u60a3\u8005\uff0c\u5176\u4e2dEPclin\u9ad8\u5371\u60a3\u8005\u5171695\u4f8b\uff0c\u5360\u6bd457.8%\uff0c\u800c449\u4f8bKi-67\u9ad8\u8868\u8fbe\u7ec4\u60a3\u8005\u4e2d\uff08Ki-67\uff1e20%\uff09\u6709118\u4f8b\u60a3\u8005\uff08\u5360\u6bd426.3%\uff09\u88ab\u8bc4\u4f30\u4e3aEPclin\u4f4e\u5371\u3002<\/li>\n
  3. Ki-67\u5728\u4ee510%\u548c30%\u4e3a\u4e34\u754c\u503c\u65f6\uff0c\u540c\u6837\u53ef\u4ee5\u5f97\u5230\u7c7b\u4f3c\u5206\u6790\u7ed3\u679c\uff1a\u4f4e\u8868\u8fbe\u7ec4\u4e2d\uff08N=557, \uff1c10%\uff09\u6709299\u4f8b\uff08\u5360\u6bd453.7%\uff09\u88ab\u8bc4\u4f30\u4e3aEPclin\u9ad8\u5371\uff0c\u800c\u9ad8\u8868\u8fbe\u7ec4\u4e2d\uff08N=101, \uff1e30%\uff09\u670928\u4f8b\uff08\u5360\u6bd427.7%\uff09\u88ab\u8bc4\u4f30\u4e3aEPclin\u4f4e\u5371\u3002<\/li>\n<\/ol>\n

    \u8fd9\u9879\u7814\u7a76\u8bc1\u660eEPclin\u98ce\u9669\u8bc4\u5206\u5728Ki-67\u4e0d\u540c\u4e9a\u7ec4\u4e4b\u95f4\u7684\u5206\u5e03\u5b58\u5728\u5dee\u5f02\uff0c\u5c24\u5176\u662f\u5728Ki-67\u4f4e\u8868\u8fbe\u7ec4\uff08<10\uff05\uff09\u6709\u5f88\u5927\u6bd4\u4f8b\u7684EPclin\u9ad8\u98ce\u9669\u60a3\u8005\uff0cKi-67\u9ad8\u8868\u8fbe\u7ec4\uff08> 30\uff05\uff09\u80bf\u7624\u4e2d\u540c\u6837\u6709\u4e00\u5b9a\u6bd4\u4f8b\u7684EPclin\u4f4e\u98ce\u9669\u60a3\u8005\uff1b\u800c\u65e2\u5f80\u7814\u7a76\u3010<\/sup>3<\/sup>\u3011\u3010<\/sup>4<\/sup>\u3011\u3010<\/sup>5<\/sup>\u3011<\/sup>\u8868\u660eEPclin\u4f4e\u5371\u60a3\u8005\uff0c10\u5e74\u8fdc\u5904\u590d\u53d1\u98ce\u9669\u7ea65%\uff0cEPclin\u9ad8\u5371\u60a3\u8005\uff0c10\u5e74\u8fdc\u5904\u590d\u53d1\u98ce\u9669\u7ea620%\uff1b\u56e0\u6b64\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0aKi-67\u8868\u8fbe\u7684\u9ad8\u4f4e\uff0c\u4e0d\u80fd\u5b8c\u5168\u4ee3\u8868\u60a3\u8005\u5316\u7597\u7684\u83b7\u76ca\u60c5\u51b5\u3002<\/p>\n

    \u57282012\u5e74Annals of Oncology\u6742\u5fd7\u53d1\u8868\u7684ABCSG 6&8\u7814\u7a76\u3010<\/sup>3<\/sup>\u3011<\/sup>\u4e9a\u7ec4\u5206\u6790\u4e2d\uff0c\u5bf9\u4e8eKi-67\uff1c14%\u4e9a\u7ec4\uff08N=1271\uff09\uff0cEndoPredict\u5206\u522b\u7b5b\u9009\u51fa71%\u7684\u4f4e\u5371\u60a3\u8005\u548c29%\u7684\u9ad8\u5371\u60a3\u8005\uff0810\u5e74\u8fdc\u5904\u590d\u53d1\u7387\uff1a\u4f4e\u53714.6% VS. 20.5%\uff0cp\uff1c0.001\uff09\uff0c\u800c\u5bf9\u4e8eKi-67\u5927\u4e8e\u7b49\u4e8e<\/span>14%\u4e9a\u7ec4\uff08N=367\uff09, EndoPredict\u5206\u522b\u7b5b\u9009\u51fa34%\u7684\u4f4e\u5371\u60a3\u8005\u548c66%\u7684\u9ad8\u5371\u60a3\u8005\uff0810\u5e74\u8fdc\u5904\u590d\u53d1\u7387\uff1a\u4f4e\u53716.8% VS. 29.0%\uff0cp\uff1c0.001\uff09\uff0c\u8bc1\u660eEndoPredict\u7684\u786e\u53ef\u4ee5\u5728Ki-67\u4e0d\u540c\u4e9a\u7ec4\u4e2d\u8fdb\u4e00\u6b65\u533a\u5206\u9884\u540e\uff0c\u5373\u4fbf\u662f\u5728Ki-67\u660e\u786e\u7684\u4f4e\u8868\u8fbe\u6216\u9ad8\u8868\u8fbe\u7684\u60a3\u8005\u4eba\u7fa4\u4e2d\u4ecd\u5177\u6709\u8f83\u5927\u7684\u68c0\u6d4b\u4ef7\u503c\u3002<\/p>\n

    \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cKi-67\u8868\u8fbe\u9ad8\u4f4e\u7684\u5206\u754c\u7ebf\u4ecd\u672a\u660e\u786e\uff0c\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u4e73\u817a\u764c\u8bca\u7597\u6307\u5357\u3010<\/sup>6<\/sup>\u3011<\/sup>\u63a8\u835015%-30%\u65f6\uff0c\u5316\u7597\u83b7\u76ca\u4e0d\u786e\u5b9a\uff0c\u800cKi-67\u56fd\u9645\u5171\u8bc6\u8ba4\u4e3a5%-30%\u4e4b\u95f4\uff0c\u68c0\u6d4b\u4e00\u81f4\u6027\u8f83\u5dee\uff0c\u9700\u8981\u53c2\u8003\u591a\u57fa\u56e0\u68c0\u6d4b\u3002<\/p>\n

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    EndoPredict\uff08\u95ee\u8c31\u7279\u3001EPclin\u300112\u57fa\u56e0\uff09\u7b2c\u4e8c\u4ee3\u4e73\u817a\u764c\u591a\u57fa\u56e0\u68c0\u6d4b\u7cbe\u51c6\u9884\u540e\uff0c\u4e3a\u75c5\u7406\u548c\u4e34\u5e8a\u63d0\u4f9b\u4e00\u4e2a\u66f4\u5168\u9762\u7684\u89c6\u89d2\u8bc4\u4f30\u60a3\u8005\u7684\u9884\u540e\u3002<\/p>\n

    \n\n\n\n\n\n\n\n\n\n
    \n

    \u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<\/td>\n<\/tr>\n

    \n

    1.         \u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u4e73\u817a\u764c\u8bca\u6cbb\u6307\u5357\u4e0e\u89c4\u8303(2021\u5e74\u7248)[J]. \u4e2d\u56fd\u764c\u75c7\u6742\u5fd7, 2021, 31(10):87.<\/span><\/p>\n<\/td>\n<\/tr>\n

    \n

    2.         2020 SABCS PS4-21.<\/span><\/p>\n<\/td>\n<\/tr>\n

    \n

    3.         EndoPredict improves the prognostic classification derived from common clinical guidelines in ER-positive, HER2-negative early breast cancer[J]. Annals of Oncology Official Journal of the European Society for Medical Oncology, 2013, 24(3):640-647.<\/span><\/p>\n<\/td>\n<\/tr>\n

    \n

    4.         Richard B , Ivana S , Ralf K , et al. Comparison of EndoPredict and EPclin With Oncotype DX Recurrence Score for Prediction of Risk of Distant Recurrence After Endocrine Therapy[J]. Jnci Journal of the National Cancer Institute(11):djw149.<\/span><\/p>\n<\/td>\n<\/tr>\n

    \n

    5.         Constantinidou A,Marcou Y ,Simmons T , et al. Clinical validation of EndoPredict in premenopausal women with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) primary breast cancer[J]. Journal of Clinical Oncology, 2021, 39(15_suppl):537-537.<\/span><\/p>\n<\/td>\n<\/tr>\n

    \n

    6.         \u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u4e73\u817a\u764c\u8bca\u7597\u6307\u5357\uff082021\u5e74\u7248\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    Ki-67\u51b3\u5b9a\u5316\u7597\u5fc5\u8981\u6027\uff1fKi-67\u4e0e\u9884\u540e\u7684\u5173\u7cfb \u6e56\u5dde2022\u5e746\u670813\u65e5 \/\u7f8e\u901a\u793e\/ — \u8fd1\u671f\uff0c\u7531\u6570\u95ee\u751f\u7269\u72ec\u5bb6\u5f15\u8fdb\u7684EndoPredict\uff08\u95ee\u8c31\u7279\u3001EPclin\u300112\u57fa\u56e0\uff09\u7cbe\u51c6\u8bc4\u4f30\u60a3\u8005\u8fdc\u671f\u9884\u540e\uff0c\u7acb\u8db3\u4e8e\u57fa\u56e0\u8bc4\u4f30\uff0c\u7740\u773c\u4e8e\u4e34\u5e8a\u56e0\u7d20\uff0c\u4e3a\u4e73\u817a\u764c\u9884\u540e\u8bc4\u4f30\u63d0\u4f9b\u65b0\u89c6\u89d2\uff0c\u52a9\u529b\u4e73\u817a\u764c\u4e2a\u4f53\u5316\u8bca\u7597\u65b0\u7bc7\u7ae0\u3002 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\u6709\u4e00\u9879\u7814\u7a76\u9488\u5bf9Ki-67\u8868\u8fbe\u5f3a\u5ea6\u4e0e\u4e73\u817a\u764c\u8fdc\u5904\u590d\u53d1\u98ce\u9669\u7684\u5173\u7cfb\u8fdb\u884c\u4e86\u5206\u6790\u30022020\u5e74\u5723\u5b89\u4e1c\u5c3c\u5965\u56fd\u9645\u4e73\u817a\u764c\u4f1a\u8bae\uff08SABCS\uff09\u4e0a\u53d1\u5e03\u4e86\u4e00\u9879\u5728\u771f\u5b9e\u4e16\u754c\u4e2d\u4e0e\u4e34\u5e8a\u6307\u6807\u5bf9\u6bd4\u5206\u6790\u7684\u6458\u8981\u7814\u7a76\u30102\u3011\u3002\u8be5\u7814\u7a76\u56de\u987e\u6027\u5206\u6790\u4e86\u4ece2017-2020\u5e74\u671f\u95f4\u5728\u4e34\u5e8a\u8bca\u7597\u4e2d\u8fdb\u884c\u8fc7EndoPredict\uff08EPclin\u300112\u57fa\u56e0\uff09\u68c0\u6d4b\u76841652\u4f8bER\u9633\u6027\u3001HER2\u9634\u6027\u65e9\u671f\u4e73\u817a\u764c\u6837\u672c\uff0c\u5206\u522b\u4eceKi-67\u3001EPclin\u8bc4\u5206\u533a\u5206\u7684\u4e9a\u7ec4\u8fdb\u884c\u5206\u6790\u3002 \u7ed3\u679c\u663e\u793a\uff1a 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