{"id":69525,"date":"2022-06-14T15:06:00","date_gmt":"2022-06-14T08:06:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022061415060069525"},"modified":"2022-06-14T21:49:27","modified_gmt":"2022-06-14T13:49:27","slug":"%e5%85%a8%e7%90%83%e9%a6%96%e4%b8%aa%e7%ba%a2%e7%bb%86%e8%83%9e%e6%88%90%e7%86%9f%e5%89%82%e5%88%a9%e5%b8%83%e6%b4%9b%e6%b3%bd%e5%9c%a8%e5%9b%bd%e5%86%85%e4%b8%8a%e5%b8%82","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022061415060069525","title":{"rendered":"\u5168\u7403\u9996\u4e2a\u7ea2\u7ec6\u80de\u6210\u719f\u5242\u5229\u5e03\u6d1b\u6cfd\u00ae\u5728\u56fd\u5185\u4e0a\u5e02"},"content":{"rendered":"

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β-\u5730\u4e2d\u6d77\u8d2b\u8840\u662f\u4e00\u79cd\u7531\u73e0\u86cb\u767d\u80bd\u94fe\u57fa\u56e0\u7a81\u53d8\u6216\u7f3a\u5931\u5f15\u8d77\u7684\u9057\u4f20\u6027\u8840\u6db2\u75be\u75c5[2]<\/sup>\uff0c\u65e0\u6548\u9020\u8840\u662fβ-\u5730\u8d2b\u7684\u91cd\u8981\u75c5\u7406\u751f\u7406\u5b66\u673a\u5236\u4e4b\u4e00\uff0c\u4f1a\u5bfc\u81f4\u4e0d\u5065\u5eb7\u7ea2\u7ec6\u80de\u7684\u4ea7\u751f\u53ca\u6b63\u5e38\u7ea2\u7ec6\u80de\u6570\u76ee\u51cf\u5c11\uff0c\u4ece\u800c\u5f15\u53d1\u4e25\u91cd\u8d2b\u8840\u3002\u5728\u4e2d\u56fd\uff0c\u5e7f\u4e1c\u3001\u5e7f\u897f\u3001\u798f\u5efa\u3001\u4e91\u5357\u3001\u8d35\u5dde\u3001\u56db\u5ddd\u3001\u6d77\u5357\u7b49\u5730\u662f\u5176\u9ad8\u53d1\u5730\u533a\u3002<\/p>\n

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“\u4f5c\u4e3a\u521b\u65b0\u6cbb\u7597\u836f\u7269\uff0c\u7f57\u7279\u897f\u666e\u80fd\u6709\u6548\u5730\u964d\u4f4e\u8f93\u8840\u4f9d\u8d56\u578bβ-\u5730\u4e2d\u6d77\u8d2b\u8840\u60a3\u8005\u7684\u8f93\u8840\u8d1f\u62c5\uff0c\u4e3a\u7f13\u89e3\u793e\u4f1a\u8840\u6e90\u7d27\u5f20\u5e26\u6765\u4e86\u79ef\u6781\u610f\u4e49\u3002\u7ecf\u4f30\u7b97\uff0c\u5e94\u7b54\u4e2d\u56fd\u60a3\u8005\u7684\u5e74\u8f93\u8840\u91cf\u6709\u671b\u964d\u4f4e\u7ea657%[5]<\/sup>\u3002\u800cIII\u671f\u4e34\u5e8a\u7814\u7a76BELIEVE\u8bc1\u5b9e\uff0c\u4f7f\u7528\u7f57\u7279\u897f\u666e\u8fdb\u884c\u6cbb\u7597\uff0c\u60a3\u8005\u8f93\u8840\u8d1f\u62c5\u8f83\u57fa\u7ebf\u964d\u4f4e≥33%\u7684\u6bd4\u4f8b\u5728\u7b2c13\u81f324\u5468\u662f\u5b89\u6170\u5242\u7ec4\u7684\u8fd15\u500d\uff0821.4% vs 4.5%)\uff0c\u8be5\u6bd4\u4f8b\u5728\u4efb\u610f24\u5468\u662f\u5b89\u6170\u5242\u7ec4\u768415\u500d (41.1% vs 2.7%)\u3002”\u4e2d\u534e\u533b\u5b66\u4f1a\u8840\u6db2\u5b66\u5206\u4f1a\u5e38\u59d4\u3001\u7ea2\u7ec6\u80de\u75be\u75c5\u5b66\u7ec4\u7ec4\u957f\u3001\u7518\u8083\u7701\u8840\u6db2\u75c5\u4e34\u5e8a\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u3001\u5170\u5927\u4e8c\u9662\u8840\u6db2\u5b66\u79d1\u5e26\u5934\u4eba\u5f20\u8fde\u751f\u6559\u6388\u8868\u793a<\/strong>\uff0c”\u5728\u521a\u521a\u7ed3\u675f\u76842022\u6b27\u6d32\u8840\u6db2\u5b66\u534f\u4f1a\u5e74\u4f1a\uff08EHA\uff09\u4e0a\uff0cBELIEVE\u7814\u7a76\u7684\u957f\u671f\u7597\u6548\u53ca\u5b89\u5168\u6027\u6570\u636e\u516c\u5e03\uff0c\u6570\u636e\u663e\u793a\uff0c\u7f57\u7279\u897f\u666e\u7ec4\u60a3\u8005\u5728\u4e2d\u4f4d\u6cbb\u7597\u7ea6154\u5468\u7684\u60c5\u51b5\u4e0b\uff0c\u66f4\u591a\u60a3\u8005\u8f93\u8840\u8d1f\u62c5\u964d\u4f4e\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\uff0c\u518d\u6b21\u8bc1\u5b9e\u957f\u671f\u63a5\u53d7\u7f57\u7279\u897f\u666e\u6cbb\u7597\u80fd\u591f\u4e3a\u60a3\u8005\u5e26\u6765\u6301\u7eed\u83b7\u76ca\u3002”<\/p>\n

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\u4e3a\u6b64\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u4e0e\u5317\u4eac\u65b0\u9633\u5149\u6148\u5584\u57fa\u91d1\u4f1a\u5c55\u5f00\u6df1\u5ea6\u5408\u4f5c\uff0c\u4ece\u4e86\u89e3\u60a3\u8005\u7684\u6cbb\u7597\u548c\u751f\u6d3b\u73b0\u72b6\u5165\u624b\uff0c\u901a\u8fc7\u53d1\u5e03\u62a5\u544a\u3001\u8d4b\u80fd\u60a3\u8005\u7ec4\u7ec7\u3001\u5f00\u5c55\u75be\u75c5\u6559\u80b2\u7b49\u65b9\u5f0f\u6765\u63d0\u5347\u60a3\u8005\u7684\u6574\u4f53\u8ba4\u77e5\u6c34\u5e73\uff0c\u52a0\u5f3a\u89c4\u8303\u5316\u6cbb\u7597\u610f\u8bc6\u3002<\/p>\n

\u5317\u4eac\u65b0\u9633\u5149\u6148\u5584\u57fa\u91d1\u4f1a\u79d8\u4e66\u957f\u5218\u6b63\u741b<\/strong>\u8868\u793a\uff0c”\u901a\u8fc7\u8c03\u7814\uff0c\u6211\u4eec\u770b\u5230\u4e86\u91cd\u578bβ-\u5730\u8d2b\u6210\u4eba\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u6240\u9762\u4e34\u7684\u56f0\u5883\uff0c\u8f93\u8840\u56f0\u96be\u3001\u7ecf\u6d4e\u8d1f\u62c5\u6c89\u91cd\u7b49\u95ee\u9898\u4f7f\u5f97\u90e8\u5206\u60a3\u8005\u65e0\u6cd5\u5b8c\u6210\u89c4\u8303\u5316\u6cbb\u7597\uff0c\u5bfc\u81f4\u5e76\u53d1\u75c7\u7684\u53d1\u751f\u548c\u9884\u671f\u5bff\u547d\u7684\u51cf\u5c11\u3002\u800c\u7ec8\u751f\u8f93\u8840\u548c\u795b\u94c1\u6cbb\u7597\u5bf9\u60a3\u8005\u7684\u5de5\u4f5c\u548c\u5b66\u4e60\u5747\u4ea7\u751f\u4e86\u4e25\u91cd\u5f71\u54cd\uff0c\u9ad8\u8fbe72%\u7684\u6210\u5e74\u60a3\u8005\u65e0\u6cd5\u53c2\u52a0\u5de5\u4f5c\u5e76\u9020\u6210\u4e3b\u8981\u7167\u62a4\u8005\u8bef\u5de5\u635f\u5931\u3002\u4e3a\u6b64\uff0c\u6211\u4eec\u5e0c\u671b\u901a\u8fc7\u542f\u52a8”\u5173\u7231\u5730\u8d2b\u60a3\u8005\uff0c\u76ca\u8d77\u5411\u672a\u6765”\u7cfb\u5217\u6d3b\u52a8\uff0c\u8d4b\u80fd\u60a3\u8005\u7ec4\u7ec7\u63d0\u5347\u8fd0\u8425\u53ca\u4f20\u64ad\u80fd\u529b\uff0c\u901a\u8fc7\u5e7f\u6cdb\u5f00\u5c55\u75be\u75c5\u6559\u80b2\uff0c\u5f3a\u5316\u60a3\u8005\u89c4\u8303\u5316\u6cbb\u7597\u610f\u8bc6\uff0c\u8ba9\u66f4\u591a\u4eba\u4e86\u89e3\u5e76\u83b7\u76ca\u4e8e\u521b\u65b0\u6cbb\u7597\uff0c\u52a9\u529b\u66f4\u591a\u9752\u58ee\u5e74\u60a3\u8005\u91cd\u8fd4\u793e\u4f1a\uff0c\u63d0\u5347\u751f\u4ea7\u529b\u3002”<\/p>\n

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\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u4e2d\u56fd\u533a\u603b\u88c1\u9648\u601d\u6e0a<\/strong>\u8868\u793a\uff0c”\u5229\u5e03\u6d1b\u6cfd®<\/sup><\/strong>\u662f\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u542f\u52a8\u5168\u65b0‘\u4e2d\u56fd2030\u6218\u7565’\u540e\u5728\u8840\u6db2\u5b66\u9886\u57df\u83b7\u6279\u7684\u7b2c\u4e00\u4e2a\u521b\u65b0\u836f\u7269\uff0c\u5177\u6709\u91cc\u7a0b\u7891\u610f\u4e49\u3002\u836f\u7269\u7684\u4e0a\u5e02\u53ea\u662f\u7b2c\u4e00\u6b65\uff0c\u5982\u4f55\u66f4\u597d\u5730\u5e94\u7528\u4e8e\u4e34\u5e8a\uff0c\u4e3a\u60a3\u8005\u5e26\u6765\u751f\u547d\u7684”\u624b\u62a4”\u662f\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u77e2\u5fd7\u4e0d\u6e1d\u7684\u627f\u8bfa\u3002\u6211\u4eec\u975e\u5e38\u8363\u5e78\u80fd\u591f\u5728\u4e1a\u754c\u4e13\u5bb6\u7684\u652f\u6301\u4e0b\uff0c\u548c\u5317\u4eac\u5eb7\u76df\u6148\u5584\u57fa\u91d1\u4f1a\u4ee5\u53ca\u5317\u4eac\u65b0\u9633\u5149\u6148\u5584\u57fa\u91d1\u4f1a\u5408\u4f5c\uff0c\u5728\u4e13\u4e1a\u9886\u57df\u548c\u516c\u4f17\u5c42\u9762\u534f\u529b\u63d0\u5347\u89c4\u8303\u5316\u548c\u521b\u65b0\u6cbb\u7597\u610f\u8bc6\uff0c\u4e5f\u5e0c\u671b\u5728\u672a\u6765\u80fd\u591f\u4e0e\u5404\u65b9\u5171\u540c\u52aa\u529b\uff0c\u591a\u63aa\u5e76\u4e3e\uff0c\u901a\u8fc7\u521b\u65b0\u7684\u51c6\u5165\u6a21\u5f0f\u52a9\u529b\u836f\u7269\u53ef\u53ca\u6027\u7684\u63d0\u9ad8\uff0c\u8ba9\u66f4\u591a\u60a3\u8005\u53ca\u5bb6\u5ead\u83b7\u76ca\u3002”<\/p>\n","protected":false},"excerpt":{"rendered":"

‘\u5e03’\u5c40\u521b\u65b0\u6cbb\u7597\uff0c‘\u6cfd’\u8000\u5730\u8d2b\u60a3\u8005 \u4e0a\u6d772022\u5e746\u670814\u65e5 \/\u7f8e\u901a\u793e\/ — \u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u5ba3\u5e03\uff0c\u5168\u7403\u9996\u4e2a\u4e14\u76ee\u524d\u552f\u4e00\u7ea2\u7ec6\u80de\u6210\u719f\u5242\u5229\u5e03\u6d1b\u6cfd®\uff08\u901a\u7528\u540d”\u6ce8\u5c04\u7528\u7f57\u7279\u897f\u666e”\uff09\u4e8e\u4eca\u65e5\u6b63\u5f0f\u5728\u56fd\u5185\u4e0a\u5e02\u3002\u4f5c\u4e3a\u5341\u4f59\u5e74\u6765\u56fd\u5185\u9996\u4e2a\u6cbb\u7597β-\u5730\u4e2d\u6d77\u8d2b\u8840\uff08\u540e\u79f0‘β-\u5730\u8d2b’\uff09\u7684\u521b\u65b0\u836f\u7269\uff0c\u5229\u5e03\u6d1b\u6cfd®\u5c06\u7528\u4e8e\u6cbb\u7597\u9700\u8981\u5b9a\u671f\u8f93\u6ce8\u7ea2\u7ec6\u80de\u4e14\u7ea2\u7ec6\u80de\u8f93\u6ce8≤15\u5355\u4f4d[1]\/24\u5468\u7684β-\u5730\u4e2d\u6d77\u8d2b\u8840\u6210\u4eba\u60a3\u8005\u3002 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\u7834\u89e3\u4f20\u7edf\u6cbb\u7597\u96be\u9898\uff0c\u52a9‘\u5229’\u51cf\u8f7b\u8f93\u8840\u8d1f\u62c5 β-\u5730\u4e2d\u6d77\u8d2b\u8840\u662f\u4e00\u79cd\u7531\u73e0\u86cb\u767d\u80bd\u94fe\u57fa\u56e0\u7a81\u53d8\u6216\u7f3a\u5931\u5f15\u8d77\u7684\u9057\u4f20\u6027\u8840\u6db2\u75be\u75c5[2]\uff0c\u65e0\u6548\u9020\u8840\u662fβ-\u5730\u8d2b\u7684\u91cd\u8981\u75c5\u7406\u751f\u7406\u5b66\u673a\u5236\u4e4b\u4e00\uff0c\u4f1a\u5bfc\u81f4\u4e0d\u5065\u5eb7\u7ea2\u7ec6\u80de\u7684\u4ea7\u751f\u53ca\u6b63\u5e38\u7ea2\u7ec6\u80de\u6570\u76ee\u51cf\u5c11\uff0c\u4ece\u800c\u5f15\u53d1\u4e25\u91cd\u8d2b\u8840\u3002\u5728\u4e2d\u56fd\uff0c\u5e7f\u4e1c\u3001\u5e7f\u897f\u3001\u798f\u5efa\u3001\u4e91\u5357\u3001\u8d35\u5dde\u3001\u56db\u5ddd\u3001\u6d77\u5357\u7b49\u5730\u662f\u5176\u9ad8\u53d1\u5730\u533a\u3002 \u4f20\u7edf\u6cbb\u7597\u65b9\u6848\u4e2d\uff0c\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u662f\u552f\u4e00\u53ef\u6839\u6cbb\u7684\u6cbb\u7597\u624b\u6bb5[3]\u3002\u4f46\u5b58\u5728\u9700\u8981\u914d\u578b\u3001\u79fb\u690d\u76f8\u5173\u526f\u53cd\u5e94\u3001\u5e74\u9f84\u9650\u5236\u7b49\u95ee\u9898\uff0c\u5bf9\u4e8e\u65e0\u6cd5\u63a5\u53d7\u79fb\u690d\u7684\u6210\u4eba\u60a3\u8005\uff0c\u5219\u9700\u8981\u957f\u671f\u63a5\u53d7\u89c4\u8303\u5316\u7684\u8f93\u8840\u548c\u795b\u94c1\u6cbb\u7597[4]\u3002\u53d7\u9650\u4e8e\u8840\u6e90\u7d27\u5f20\uff0c\u957f\u671f\u8f93\u8840\u5bfc\u81f4\u7684\u94c1\u8fc7\u8f7d\u548c\u6f5c\u5728\u611f\u67d3\u98ce\u9669\u7b49\u56e0\u7d20\uff0c\u4f7f\u5f97\u60a3\u8005\u7ec8\u8eab\u8f93\u8840\u96be\u4ee5\u4fdd\u969c\uff0c\u5bf9\u4e8e\u521b\u65b0\u836f\u7269\u7684\u9700\u6c42\u8feb\u5728\u7709\u776b\u3002 \u5229\u5e03\u6d1b\u6cfd®\u7684\u83b7\u6279\u4e0a\u5e02\uff0c\u4e3aβ-\u5730\u8d2b\u60a3\u8005\u5e26\u6765\u4e86\u9664\u4f20\u7edf\u8f93\u8840\u53ca\u795b\u94c1\u4ee5\u5916\u7684\u6cbb\u7597\u65b0\u9009\u62e9\u3002\u4e0e\u4f20\u7edf\u673a\u5236\u4e0d\u540c\uff0c\u5229\u5e03\u6d1b\u6cfd®\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u878d\u5408\u86cb\u767d\uff0c\u4f5c\u7528\u4e8e\u7ea2\u7ec6\u80de\u6210\u719f\u7684\u665a\u671f\u9636\u6bb5\uff0c\u901a\u8fc7\u4e0e\u8c03\u63a7\u7ea2\u7ec6\u80de\u6210\u719f\u7684\u5173\u952e\u7ec6\u80de\u56e0\u5b50——TGF-β\u8d85\u5bb6\u65cf\u914d\u4f53\u7ed3\u5408\uff0c\u964d\u4f4e\u5f02\u5e38\u589e\u5f3a\u7684Smad 2\/3\u4fe1\u53f7\u901a\u8def\u8f6c\u5bfc\uff0c\u4ece\u800c\u4fc3\u8fdb\u665a\u671f\u7ea2\u7ec6\u80de\u6210\u719f\uff0c\u4f7f\u673a\u4f53\u80fd\u591f\u4ea7\u751f\u66f4\u591a\u6210\u719f\u7684\u7ea2\u7ec6\u80de\u3002 “\u4f5c\u4e3a\u521b\u65b0\u6cbb\u7597\u836f\u7269\uff0c\u7f57\u7279\u897f\u666e\u80fd\u6709\u6548\u5730\u964d\u4f4e\u8f93\u8840\u4f9d\u8d56\u578bβ-\u5730\u4e2d\u6d77\u8d2b\u8840\u60a3\u8005\u7684\u8f93\u8840\u8d1f\u62c5\uff0c\u4e3a\u7f13\u89e3\u793e\u4f1a\u8840\u6e90\u7d27\u5f20\u5e26\u6765\u4e86\u79ef\u6781\u610f\u4e49\u3002\u7ecf\u4f30\u7b97\uff0c\u5e94\u7b54\u4e2d\u56fd\u60a3\u8005\u7684\u5e74\u8f93\u8840\u91cf\u6709\u671b\u964d\u4f4e\u7ea657%[5]\u3002\u800cIII\u671f\u4e34\u5e8a\u7814\u7a76BELIEVE\u8bc1\u5b9e\uff0c\u4f7f\u7528\u7f57\u7279\u897f\u666e\u8fdb\u884c\u6cbb\u7597\uff0c\u60a3\u8005\u8f93\u8840\u8d1f\u62c5\u8f83\u57fa\u7ebf\u964d\u4f4e≥33%\u7684\u6bd4\u4f8b\u5728\u7b2c13\u81f324\u5468\u662f\u5b89\u6170\u5242\u7ec4\u7684\u8fd15\u500d\uff0821.4% vs 4.5%)\uff0c\u8be5\u6bd4\u4f8b\u5728\u4efb\u610f24\u5468\u662f\u5b89\u6170\u5242\u7ec4\u768415\u500d (41.1% vs 2.7%)\u3002”\u4e2d\u534e\u533b\u5b66\u4f1a\u8840\u6db2\u5b66\u5206\u4f1a\u5e38\u59d4\u3001\u7ea2\u7ec6\u80de\u75be\u75c5\u5b66\u7ec4\u7ec4\u957f\u3001\u7518\u8083\u7701\u8840\u6db2\u75c5\u4e34\u5e8a\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u3001\u5170\u5927\u4e8c\u9662\u8840\u6db2\u5b66\u79d1\u5e26\u5934\u4eba\u5f20\u8fde\u751f\u6559\u6388\u8868\u793a\uff0c”\u5728\u521a\u521a\u7ed3\u675f\u76842022\u6b27\u6d32\u8840\u6db2\u5b66\u534f\u4f1a\u5e74\u4f1a\uff08EHA\uff09\u4e0a\uff0cBELIEVE\u7814\u7a76\u7684\u957f\u671f\u7597\u6548\u53ca\u5b89\u5168\u6027\u6570\u636e\u516c\u5e03\uff0c\u6570\u636e\u663e\u793a\uff0c\u7f57\u7279\u897f\u666e\u7ec4\u60a3\u8005\u5728\u4e2d\u4f4d\u6cbb\u7597\u7ea6154\u5468\u7684\u60c5\u51b5\u4e0b\uff0c\u66f4\u591a\u60a3\u8005\u8f93\u8840\u8d1f\u62c5\u964d\u4f4e\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\uff0c\u518d\u6b21\u8bc1\u5b9e\u957f\u671f\u63a5\u53d7\u7f57\u7279\u897f\u666e\u6cbb\u7597\u80fd\u591f\u4e3a\u60a3\u8005\u5e26\u6765\u6301\u7eed\u83b7\u76ca\u3002” 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