{"id":69388,"date":"2022-06-12T19:00:00","date_gmt":"2022-06-12T12:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022061219000069388"},"modified":"2022-06-13T22:08:41","modified_gmt":"2022-06-13T14:08:41","slug":"%e4%ba%98%e5%96%9c%e7%94%9f%e7%89%a9%e5%9c%a8eha2022%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83bcma-cd19%e5%8f%8c%e9%9d%b6%e7%82%b9-fastcar%e5%80%99%e9%80%89%e4%ba%a7%e5%93%81gc012f%e6%b2%bb","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022061219000069388","title":{"rendered":"\u4e98\u559c\u751f\u7269\u5728EHA2022\u5e74\u4f1a\u4e0a\u516c\u5e03BCMA\/CD19\u53cc\u9776\u70b9 FasTCAR\u5019\u9009\u4ea7\u54c1GC012F\u6cbb\u7597RRMM\u7684\u66f4\u65b0\u4e34\u5e8a\u6570\u636e\uff0c100%\u60a3\u8005\u8fbe\u5230MRD\u9634\u6027"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/Logo-335.jpg\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><p><i>\u4e98\u559c\u751f\u7269\u540c\u6b65\u53d1\u8868\u4e86<\/i><i>GC012F<\/i><i>\u6cbb\u7597<\/i><i>B-NHL<\/i><i>\u4ee5\u53ca\u540c\u79cd\u5f02\u4f53<\/i><i>CAR-T GC502<\/i><i>\u6cbb\u7597<\/i><i>B-ALL<\/i><i>\u7684\u4e34\u5e8a\u6570\u636e<\/i><\/p>\n<p><i>\u516c\u53f8\u7ba1\u7406\u5c42\u5c06\u4e8e\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f4<\/i><i>6<\/i><i>\u6708<\/i><i>13<\/i><i>\u65e5\uff08\u5468\u4e00\uff09\u4e0a\u5348<\/i><i>8<\/i><i>\u70b9\u53ec\u5f00\u4e34\u5e8a\u6570\u636e\u89e3\u8bfb\u4f1a<\/i><\/p>\n<p><span class=\"legendSpanClass\">\u4e2d\u56fd\u6c5f\u82cf\u82cf\u5dde\u3001\u4e0a\u6d77\u548c\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5723\u8fed\u6208<\/span><span class=\"legendSpanClass\">2022\u5e746\u670812\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u4e98\u559c\u751f\u7269\u79d1\u6280\u96c6\u56e2\uff08\u7b80\u79f0&quot;\u4e98\u559c\u751f\u7269&quot;\u6216&quot;\u516c\u53f8&quot;\uff1b\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aGRCL\uff09\u4e00\u5bb6\u81f4\u529b\u4e8e\u5f00\u53d1\u9ad8\u6548\u3001\u7ecf\u6d4e\u7684\u7ec6\u80de\u7597\u6cd5\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u5168\u7403\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5728\u5965\u5730\u5229\u7ef4\u4e5f\u7eb3\u53ec\u5f00\u7684\u6b27\u6d32\u8840\u6db2\u5b66\u534f\u4f1a\uff08EHA\uff092022\u5e74\u4f1a\u4e0a\u6b63\u5f0f\u53d1\u8868\u4e86\u65d7\u4e0bB\u7ec6\u80de\u6210\u719f\u6297\u539f\uff08BCMA\uff09\/CD19\u53cc\u9776\u70b9\u81ea\u4f53CAR-T\u5019\u9009\u4ea7\u54c1GC012F\u57fa\u4e8e\u4e00\u9879\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08RRMM\uff09\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\u7684\u66f4\u65b0\u6570\u636e\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p>&quot;\u5728\u521a\u521a\u8fc7\u53bb\u7684ASCO\u5e74\u4f1a\u4e0a\uff0c\u6211\u4eec\u516c\u5e03\u4e86GC012F\u6cbb\u7597RRMM\u79ef\u6781\u7684\u4e34\u5e8a\u7ed3\u679c\uff0c\u5f88\u9ad8\u5174\u80fd\u7d27\u63a5\u7740\u5728EHA\u5e74\u4f1a\u4e0a\u7ee7\u7eed\u5206\u4eab\u66f4\u591a\u8fdb\u5c55\u3002\u6700\u65b0\u6570\u636e\u663e\u793a\uff0c29\u4f8b\u60a3\u8005100%\u8fbe\u5230MRD\u9634\u6027\uff0c\u8fdb\u4e00\u6b65\u660e\u786e\u4e86\u5176\u6df1\u5ea6\u5e94\u7b54\u7684\u7597\u6548\u3002&quot;\u4e98\u559c\u751f\u7269\u9996\u5e2d\u533b\u5b66\u5b98Martina Sersch\u535a\u58eb\u8868\u793a\uff0c&quot;GC012F\u5728\u6cbb\u7597RRMM\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\u4e0d\u65ad\u5c55\u73b0\u51fa\u53ef\u9760\u7684\u5b89\u5168\u6027\u548c\u6301\u4e45\u7f13\u89e3\u7684\u5353\u8d8a\u7597\u6548\uff0c\u5373\u4f7f\u9488\u5bf9\u4f34\u6709\u9ad3\u5916\u75c5\u53d8\u548c\u63a5\u53d7\u8fc7\u86cb\u767d\u9176\u6291\u5236\u5242\u3001\u514d\u75ab\u8c03\u8282\u6291\u5236\u5242\u4ee5\u53ca\u6297CD38\u5355\u6297\u7b49\u591a\u91cd\u65e2\u5f80\u6cbb\u7597\u7684\u9ad8\u5371\u60a3\u8005\uff0c\u4ecd\u7136\u53d6\u5f97\u4e86\u4ee4\u4eba\u9f13\u821e\u768415.7\u4e2a\u6708\u7684\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08mDoR\uff09\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u6211\u4eec\u8fd8\u5728EHA\u5e74\u4f1a\u4e0a\u9996\u6b21\u516c\u5e03\u4e86GC012F\u9488\u5bf9\u53e6\u4e00\u9879\u9002\u5e94\u75c7B-NHL\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u7ed3\u679c\u540c\u6837\u559c\u4eba\u3002\u63a5\u4e0b\u6765\uff0c\u6211\u4eec\u5c06\u5168\u529b\u63a8\u8fdb\u8be5\u6838\u5fc3\u4ea7\u54c1\u7684\u5404\u9879\u7814\u7a76\uff0c\u65e9\u65e5\u4e3a\u4e34\u5e8a\u672a\u5c3d\u4e4b\u9700\u5e26\u6765\u6f5c\u5728\u9769\u65b0\u7597\u6cd5\u3002&quot;<\/p>\n<p>\u6b64\u524d\uff0c\u4e98\u559c\u751f\u7269\u8fd8\u57286\u670810\u65e5\u53d1\u8868\u4e86\u4e00\u9879\u8bc4\u4f30GC012F\u6cbb\u7597B\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08B-NHL\uff09\u60a3\u8005\u5b89\u5168\u6027\u53ca\u8010\u53d7\u6027\u7684\u7531\u7814\u7a76\u8005\u53d1\u8d77\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff08IIT\uff09\u7684\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\uff08FIH\uff09\u6570\u636e\uff0c\u4ee5\u53ca\u4e00\u9879\u8bc4\u4f30\u540c\u79cd\u5f02\u4f53TruUCAR-T GC502\u6cbb\u7597\u6025\u6027B\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08B-ALL\uff09\u60a3\u8005\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027IIT\u7684\u66f4\u65b0\u4e34\u5e8a\u6570\u636e\u3002\u516c\u53f8\u4e8e5\u670812\u65e5\u901a\u8fc7<a href=\"https:\/\/cn.gracellbio.com\/html\/newsroom\/110.html\" target=\"_blank\" rel=\"nofollow noopener\"><span id=\"spanHghlt3e09\">\u65b0\u95fb\u7a3f<\/span><\/a>\u53d1\u5e03\u4e86\u4e0a\u8ff0\u6570\u636e\u8be6\u60c5\u3002<\/p>\n<p><b>BCMA\/CD19<\/b><b>\u53cc\u9776\u70b9<\/b><b>FasTCAR-T GC012F<\/b><b>\u6cbb\u7597<\/b><b>RRMM<\/b><\/p>\n<p>\u81ea2019\u5e7410\u6708\u81f32022\u5e741\u6708\uff0c\u8fd9\u9879\u5355\u81c2\u3001\u5f00\u653e\u6027\u3001\u591a\u4e2d\u5fc3\u7684IIT\u7814\u7a76\u5171\u8ba1\u5165\u7ec4\u4e8629\u4f8b\u63a5\u53d7\u8fc7\u6df1\u5ea6\u65e2\u5f80\u6cbb\u7597\u7684RRMM\u60a3\u8005\uff0c\u5165\u7ec4\u60a3\u8005\u5206\u522b\u63a5\u53d7\u4e86GC012F\u4e09\u79cd\u5242\u91cf\u6c34\u5e73\u7684\u5355\u6b21\u8f93\u6ce8\u6cbb\u7597\uff1a<span id=\"spanHghlt1e23\">1&#215;10<\/span><sup><span id=\"spanHghlt073b\">5<\/span><\/sup>\u7ec6\u80de\/\u516c\u65a4\u4f53\u91cd\uff08DL1\uff09\u3001<span id=\"spanHghlt3135\">2&#215;10<\/span><sup><span id=\"spanHghlt9baa\">5<\/span><\/sup>\u7ec6\u80de\/\u516c\u65a4\u4f53\u91cd\uff08DL2\uff09\u548c<span id=\"spanHghlt11b2\">3&#215;10<\/span><sup><span id=\"spanHghlt7e83\">5<\/span><\/sup>\u7ec6\u80de\/\u516c\u65a4\u4f53\u91cd\uff08DL3\uff09\u300290%\uff0826\/29\uff09\u7684\u60a3\u8005\u6839\u636emSMART 3.0\u6807\u51c6\u88ab\u5b9a\u4e49\u4e3a\u9ad8\u5371\u60a3\u8005\u3002\u6240\u6709\u60a3\u8005\u4e2d\u4f4d\u65e2\u5f80\u6cbb\u7597\u7ebf\u6570\u4e3a5\u6b21\u3002&nbsp;<\/p>\n<p>\u622a\u81f32022\u5e746\u67088\u65e5\u6570\u636e\u622a\u6b62\u65e5\uff0c29\u4f8b\u60a3\u8005\u63a5\u53d7\u4e86\u7597\u6548\u8bc4\u4f30\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a11\u4e2a\u6708\uff08\u8303\u56f4\uff1a4.9 &#8211; 34.5\u4e2a\u6708\uff09\uff1b\u76ee\u524d\uff0c\u8be5\u7814\u7a76\u4ecd\u5728\u5bf9\u60a3\u8005\u8fdb\u884c\u6301\u7eed\u968f\u8bbf\uff0c\u4ee5\u8bc4\u4f30\u4e0d\u65ad\u52a0\u6df1\u7684\u53cd\u5e94\u3002\u4e0d\u540c\u5242\u91cf\u6c34\u5e73\uff08DL\uff09\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u5206\u522b\u4e3aDL1\uff1a100%\uff082\/2\uff09\uff0cDL2\uff1a80%\uff088\/10\uff09\u4ee5\u53caDL3\uff1a100%\uff0817\/17\uff09\u3002\u6240\u6709\u60a3\u8005100%\uff0829\/29\uff09\u90fd\u8fbe\u5230\u4e86MRD\u9634\u6027\uff1b75.9%\uff0822\/29\uff09\u7684\u60a3\u8005\u8fbe\u5230\u4e86\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\u9634\u6027-\u4e25\u683c\u610f\u4e49\u4e0a\u7684\u5b8c\u5168\u7f13\u89e3\uff08MRD- sCR\uff09\u3002\u6570\u636e\u622a\u6b62\u65e5\u65f6\u7684mDoR \u4e3a15.7\u4e2a\u6708\uff0895%\u7f6e\u4fe1\u533a\u95f4&nbsp;[7.6-33.1] \uff09\u3002<\/p>\n<p>GC012F\u7684\u5b89\u5168\u6027\u4e0e\u6b64\u524d\u7684\u89c2\u5bdf\u7ed3\u679c\u4e00\u81f4\uff0c\u4e3b\u8981\u51fa\u73b0\u7684\u662f\u4f4e\u7ea7\u522b\u7684\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u300293%\uff0827\/29\uff09\u7684\u60a3\u8005\u51fa\u73b00-2\u7ea7CRS\uff0c7%\uff082\/29\uff09\u7684\u60a3\u8005\u51fa\u73b03\u7ea7CRS\uff0c\u5e76\u672a\u89c2\u5bdf\u52304\u7ea7\/5\u7ea7CRS\u6216\u4efb\u4f55\u7ea7\u522b\u7684\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u76f8\u5173\u795e\u7ecf\u6bd2\u6027\uff08ICANS\uff09\u3002\u8be5\u7814\u7a76\u8fd8\u5c06\u6301\u7eed\u76d1\u6d4b\u8bc4\u4f30GC012F\u6cbb\u7597\u60a3\u8005\u8fc7\u7a0b\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u5305\u62ec\u6700\u4f73\u603b\u4f53\u7f13\u89e3\u7387\uff08BOR\uff09\u4ee5\u53caDoR\u3002\u9700\u8981\u6307\u51fa\u7684\u662f\uff0c\u53d7\u6b64\u524d\u4e0a\u6d77\u65b0\u51a0\u75ab\u60c5\u5c01\u63a7\u5f71\u54cd\uff0c\u9488\u5bf9\u90e8\u5206\u60a3\u8005\u7684\u968f\u8bbf\u8bc4\u4f30\u5de5\u4f5c\u51fa\u73b0\u4e86\u5ef6\u8fdf\uff0c\u76ee\u524d\u5df2\u9010\u6b65\u6062\u590d\u3002\u516c\u53f8\u8ba1\u5212\u5728\u540e\u7eed\u7684\u5b66\u672f\u520a\u7269\u4e0a\u53d1\u8868\u5168\u4f53\u53d7\u8bd5\u8005\u66f4\u65b0\u7684\u7597\u6548\u6570\u636e\uff0c\u5305\u62ecDoR\u3001ORR\u4ee5\u53caBOR\u3002<\/p>\n<p>2021\u5e7411\u6708\uff0cGC012F\u88ab\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002<\/p>\n<p>\u53e3\u5934\u62a5\u544a\u56de\u987e\u8be6\u60c5\u5982\u4e0b\uff1a<\/p>\n<ul type=\"disc\">\n<li><b>\u6458\u8981\u6807\u9898<\/b>\uff1aBCMA\/CD19\u53cc\u9776\u70b9FasTCAR-T GC012F\u6cbb\u7597RRMM\u7684\u591a\u4e2d\u5fc3\u3001\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u7684\u6700\u65b0\u7814\u7a76\u7ed3\u679c<br \/><b>Abstract title<\/b>: Updated results of a multicenter first-in-human study of BCMA\/CD19 dual-targeting FasTCAR-T GC012F for patients with relapsed\/refractory multiple myeloma (RRMM)<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li><b>\u73af\u8282\u540d\u79f0<\/b>\uff1a\u590d\u53d1\/\u96be\u6cbb\u6027\u9aa8\u9ad3\u7624\uff1aBCMA\u9776\u5411\u7597\u6cd5<br \/><b>Session title<\/b>: Relapsed\/refractory myeloma: BCMA-directed therapies<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li><b>\u62a5\u544a\u65f6\u95f4<\/b>\uff1a6\u670812\u65e5\uff08\u661f\u671f\u65e5\uff09\uff0c\u4e2d\u6b27\u590f\u5b63\u65f6\u95f4\u4e0a\u534811:30 \u2013 \u4e0b\u534812:45<br \/><b>Presentation time<\/b>: <span class=\"xn-chron\">Sunday, June 12<\/span> from <span class=\"xn-chron\">11:30 AM<\/span> \u2013 <span class=\"xn-chron\">12:45 PM CEST<\/span><\/li>\n<\/ul>\n<ul type=\"disc\">\n<li><b>\u62a5\u544a\u5730\u70b9<\/b>\uff1aA2-A3\u5385<br \/><b>Presentation location<\/b>: Hall A2-A3<\/li>\n<\/ul>\n<p>\u6709\u5173EHA2022\u5e74\u4f1a\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u53ef\u8bbf\u95ee<a href=\"http:\/\/www.ehaweb.org\/\" target=\"_blank\" rel=\"nofollow noopener\">www.ehaweb.org<\/a>\u7f51\u7ad9\u67e5\u9605\u3002<\/p>\n<p><b>\u4e34\u5e8a\u6570\u636e\u7ebf\u4e0a\u89e3\u8bfb\u4f1a\u53c2\u4f1a\u4fe1\u606f<\/b><\/p>\n<p>\u5317\u4eac\u65f6\u95f4&nbsp; 6\u670813\u65e5&nbsp;20:00&nbsp; |&nbsp; \u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f4&nbsp;6\u670813\u65e5&nbsp;8:00<br \/>\u7ebf\u4e0a\u53c2\u4f1a\u94fe\u63a5\uff1a<a href=\"https:\/\/ir.gracellbio.com\/news-events\/events-and-presentations\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/ir.gracellbio.com\/news-events\/events-and-presentations<\/a><i>&nbsp; &nbsp; &nbsp;<br \/>\u6e29\u99a8\u63d0\u793a\uff1a\u60a8\u53ef\u4ee5\u5728\u4f1a\u8bae\u7ed3\u675f\u540e<\/i><i>90<\/i><i>\u5929\u5185\u767b\u5f55<\/i><i>&nbsp;<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=n0WvhlUNv5aEFUbhzjL43PUgiXNtqleAHCjg8keJA8aFSecLWyNhTtWwHJAuMBBxheB5XBNOL3Dw8saODmp7Acmbl_hlU0uHI1SbjabKZnM=\" target=\"_blank\" rel=\"nofollow noopener\">ir.gracellbio.com<\/a><\/i><i>\u89c2\u770b\u4f1a\u8bae\u91cd\u64ad\u3002<\/i><\/p>\n<p><b>\u5173\u4e8e<\/b><b>GC012F<\/b><\/p>\n<p>GC012F\u662f\u4e00\u6b3e\u57fa\u4e8eFasTCAR\u5e73\u53f0\u5f00\u53d1\u7684\u53cc\u9776\u70b9\u81ea\u4f53CAR-T\u7597\u6cd5\u5019\u9009\u4ea7\u54c1\u3002\u76ee\u524d\uff0c\u8be5\u5019\u9009\u4ea7\u54c1\u6b63\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u591a\u9879\u7531\u7814\u7a76\u8005\u53d1\u8d77\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc4\u4f30\u5176\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u4ee5\u53caB\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08B-NHL\uff09\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002GC012F\u901a\u8fc7\u540c\u65f6\u9776\u5411CD19\u548cBCMA\u9776\u70b9\uff0c\u80fd\u5e26\u6765\u5feb\u901f\u3001\u6df1\u5165\u4e14\u6301\u4e45\u7684\u6cbb\u7597\u6548\u679c\uff0c\u5e2e\u52a9MM\u53caB-NHL\u60a3\u8005\u63d0\u9ad8\u6cbb\u7597\u54cd\u5e94\u7387\u3001\u5e76\u6709\u671b\u964d\u4f4e\u590d\u53d1\u7387\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>FasTCAR <\/b><\/p>\n<p>FasTCAR\u662f\u4e98\u559c\u751f\u7269\u5177\u6709\u77e5\u8bc6\u4ea7\u6743\u7684\u6280\u672f\u5e73\u53f0\uff0c\u65e8\u5728\u5f00\u53d1\u9ad8\u8d28\u91cf\u7684\u81ea\u4f53CAR-T\u7ec6\u80de\u7597\u6cd5\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\uff0c\u901a\u8fc7FasTCAR\u6280\u672f\u5e73\u53f0\u751f\u4ea7\u7684CAR-T\u7ec6\u80de\u8868\u578b\u66f4\u5e74\u8f7b\u3001\u8017\u7aed\u7a0b\u5ea6\u66f4\u4f4e\uff0c\u5e76\u4e14\u6269\u589e\u80fd\u529b\u3001\u6301\u4e45\u6027\u3001\u9aa8\u9ad3\u8fc1\u79fb\u80fd\u529b\u4ee5\u53ca\u80bf\u7624\u7ec6\u80de\u6e05\u9664\u6d3b\u6027\u5747\u5f97\u5230\u589e\u5f3a\u3002\u51ed\u501f&quot;\u6b21\u65e5\u5b8c\u6210\u751f\u4ea7&quot;\u7684\u4f18\u52bf\uff0cFasTCAR\u5e73\u53f0\u6280\u672f\u80fd\u5927\u5e45\u63d0\u9ad8\u7ec6\u80de\u751f\u4ea7\u6548\u7387\uff0c\u4ece\u800c\u663e\u8457\u964d\u4f4e\u751f\u4ea7\u6210\u672c\uff1b\u540c\u65f6\uff0c\u5f97\u76ca\u4e8e\u5236\u5907\u65f6\u95f4\u5927\u5e45\u7f29\u77ed\uff0c\u4e5f\u63d0\u5347\u4e86\u7ec6\u80de\u7597\u6cd5\u5bf9\u4e8e\u764c\u75c7\u60a3\u8005\u7684\u53ef\u53ca\u6027\u3002<\/p>\n<p><b>\u5173\u4e8e\u4e98\u559c\u751f\u7269<\/b><\/p>\n<p>\u4e98\u559c\u751f\u7269\u79d1\u6280\u96c6\u56e2\uff08\u7b80\u79f0&quot;\u4e98\u559c\u751f\u7269&quot;\uff09\u662f\u4e00\u5bb6\u81f4\u529b\u4e8e\u53d1\u73b0\u548c\u5f00\u53d1\u7a81\u7834\u6027\u7ec6\u80de\u7597\u6cd5\u7684\u5168\u7403\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u5229\u7528\u5176\u5f00\u521b\u6027FasTCAR\u53caTruUCAR\u4e24\u5927\u7a81\u7834\u6027\u6280\u672f\u5e73\u53f0\u4ee5\u53caSMART CART<sup>TM<\/sup>\u6280\u672f\u6a21\u5757\uff0c\u4e98\u559c\u751f\u7269\u6b63\u5728\u5f00\u53d1\u591a\u9879\u81ea\u4f53\u548c\u540c\u79cd\u5f02\u4f53\u7684\u4e30\u5bcc\u4e34\u5e8a\u9636\u6bb5\u764c\u75c7\u6cbb\u7597\u4ea7\u54c1\u7ba1\u7ebf\u3002\u8fd9\u4e9b\u4ea7\u54c1\u6709\u671b\u653b\u514b\u4f20\u7edfCAR-T\u7597\u6cd5\u6301\u7eed\u5b58\u5728\u7684\u91cd\u5927\u884c\u4e1a\u6311\u6218\uff0c\u5305\u62ec\u751f\u4ea7\u65f6\u95f4\u957f\u3001\u4ea7\u54c1\u7ec6\u80de\u8d28\u91cf\u6b20\u4f73\u3001\u6cbb\u7597\u6210\u672c\u9ad8\u548c\u5bf9\u5b9e\u4f53\u7624\u7f3a\u4e4f\u6709\u6548\u6cbb\u7597\u7b49\u3002\u5982\u9700\u8fdb\u4e00\u6b65\u4e86\u89e3\u4e98\u559c\u751f\u7269\uff0c<a href=\"mailto:%E8%AF%B7%E8%AE%BF%E9%97%AEwww.gracellbio.com\/%E5%85%B3%E6%B3%A8%E9%A2%86%E8%8B%B1%E8%B4%A6%E5%8F%B7@GracellBio\" target=\"_blank\" rel=\"nofollow noopener\">\u8bf7\u8bbf\u95eewww.gracellbio.com\/\u5173\u6ce8\u9886\u82f1\u8d26\u53f7@GracellBio<\/a>\u3002<\/p>\n<p><b>\u5173\u4e8e\u524d\u77bb\u6027\u9648\u8ff0\u7684\u8b66\u6212\u6027\u58f0\u660e<\/b><\/p>\n<p>\u8be5\u65b0\u95fb\u7a3f\u4e2d\u9488\u5bf9\u672a\u6765\u9884\u671f\u3001\u8ba1\u5212\u3001\u524d\u666f\u4ee5\u53ca\u5176\u4ed6\u975e\u5386\u53f2\u4e8b\u5b9e\u7684\u58f0\u660e\u53ef\u80fd\u5305\u542b\u6839\u636e\u300a1995 \u5e74\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 1995\uff09\u4e0b\u5b9a\u4e49\u7684&quot;\u524d\u77bb\u6027\u58f0\u660e&quot;\u3002\u8fd9\u4e9b\u58f0\u660e\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u4e0e\u672c\u6b21\u53d1\u884c\u7684\u9884\u8ba1\u4ea4\u6613\u53ca\u5b8c\u6210\u65f6\u95f4\u76f8\u5173\u7684\u58f0\u660e\u3002\u8fd9\u4e9b\u58f0\u660e\u53ef\u80fd\u4f46\u4e0d\u4e00\u5b9a\u5305\u542b\u4e0b\u5217\u8bcd\u6c47\u4ee5\u53ca\u76f8\u5bf9\u5e94\u7684\u5426\u5b9a\u5f62\u5f0f\u6216\u76f8\u4f3c\u7684\u8bcd\u6c47\uff1a\u76ee\u7684\u4e3a\u3001\u9884\u671f\u3001\u76f8\u4fe1\u3001 \u4f30\u8ba1\u3001\u9884\u8ba1\u3001\u9884\u6d4b\u3001\u6253\u7b97\u3001\u53ef\u80fd\u3001\u524d\u666f\u3001\u8ba1\u5212\u3001\u6f5c\u5728\u3001\u63a8\u60f3\u3001\u62df\u5b9a\u3001\u5bfb\u6c42\u3001\u53ef\u80fd\u3001\u5e94\u8be5\u3001\u5c06\u3002\u7531\u4e8e\u5404\u79cd\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u58f0\u660e\u6709\u91cd\u5927\u5dee\u5f02\uff0c\u4e5f\u65e0\u6cd5\u786e\u4fdd\u4efb\u4f55\u524d\u77bb\u6027\u58f0\u660e\u4f1a\u5b9e\u73b0\u3002\u8fd9\u4e9b\u91cd\u8981\u56e0\u7d20\u5305\u62ec\u4e98\u559c\u751f\u7269\u6700\u8fd1\u5728\u5e74\u5ea6\u62a5\u544a20-F\u8868\u5355\u4e2d\u7684\u300a\u98ce\u9669\u56e0\u7d20\u300b\u7ae0\u8282\u6240\u63d0\u53ca\u7684\u56e0\u7d20\uff0c\u4ee5\u53ca\u4e98\u559c\u751f\u7269\u540e\u7eed\u5411\u7f8e\u56fd\u8bc1\u76d1\u4f1a\u671f\u540e\u5448\u62a5\u4e2d\u5173\u4e8e\u6f5c\u5728\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8ba8\u8bba\u3002\u4efb\u4f55\u672c\u58f0\u660e\u4e2d\u7684\u524d\u77bb\u6027\u58f0\u660e\u4ec5\u53cd\u5e94\u5f53\u524d\u7684\u9884\u671f\uff0c\u4e98\u559c\u751f\u7269\u5e76\u65e0\u8d23\u4efb\u516c\u5f00\u66f4\u65b0\u6216\u56de\u987e\u4efb\u4e00\u524d\u77bb\u6027\u58f0\u660e\uff0c\u65e0\u8bba\u662f\u57fa\u4e8e\u65b0\u4fe1\u606f\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u662f\u5176\u4ed6\u539f\u56e0\u3002\u8bf7\u8bfb\u8005\u4e0d\u8981\u5728\u672c\u65b0\u95fb\u7a3f\u51fa\u7248\u65e5\u4e4b\u540e\u4f9d\u8d56\u524d\u77bb\u6027\u58f0\u660e\u3002<\/p>\n<p><b>\u5a92\u4f53\u8054\u7cfb\u4eba<br \/><\/b><b>\u5510\u6021\u73ae<\/b><b>&nbsp;Marvin Tang<\/b>&nbsp; &nbsp;<br \/><a href=\"mailto:marvin.tang@gracellbio.com\" target=\"_blank\" rel=\"nofollow noopener\">marvin.tang@gracellbio.com<\/a><\/p>\n<p><b>\u6295\u8d44\u8005\u8054\u7cfb\u4eba<br \/><\/b><b>\u738b\u601d\u8fdc<\/b><b> <span class=\"xn-person\">Sarah Wang<\/span><\/b><a href=\"mailto:siyuan.wang@gracellbio.com\" target=\"_blank\" rel=\"nofollow noopener\"><br \/>siyuan.wang@gracellbio.com<\/a><\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder2\">  <\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e98\u559c\u751f\u7269\u540c\u6b65\u53d1\u8868\u4e86GC012F\u6cbb\u7597B-NHL\u4ee5\u53ca\u540c\u79cd\u5f02\u4f53CAR-T GC502\u6cbb\u7597B-ALL\u7684\u4e34\u5e8a\u6570\u636e \u516c\u53f8\u7ba1\u7406\u5c42\u5c06\u4e8e\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f46\u670813\u65e5\uff08\u5468\u4e00\uff09\u4e0a\u53488\u70b9\u53ec\u5f00\u4e34\u5e8a\u6570\u636e\u89e3\u8bfb\u4f1a 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GC012F\u7684\u5b89\u5168\u6027\u4e0e\u6b64\u524d\u7684\u89c2\u5bdf\u7ed3\u679c\u4e00\u81f4\uff0c\u4e3b\u8981\u51fa\u73b0\u7684\u662f\u4f4e\u7ea7\u522b\u7684\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u300293%\uff0827\/29\uff09\u7684\u60a3\u8005\u51fa\u73b00-2\u7ea7CRS\uff0c7%\uff082\/29\uff09\u7684\u60a3\u8005\u51fa\u73b03\u7ea7CRS\uff0c\u5e76\u672a\u89c2\u5bdf\u52304\u7ea7\/5\u7ea7CRS\u6216\u4efb\u4f55\u7ea7\u522b\u7684\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u76f8\u5173\u795e\u7ecf\u6bd2\u6027\uff08ICANS\uff09\u3002\u8be5\u7814\u7a76\u8fd8\u5c06\u6301\u7eed\u76d1\u6d4b\u8bc4\u4f30GC012F\u6cbb\u7597\u60a3\u8005\u8fc7\u7a0b\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u5305\u62ec\u6700\u4f73\u603b\u4f53\u7f13\u89e3\u7387\uff08BOR\uff09\u4ee5\u53caDoR\u3002\u9700\u8981\u6307\u51fa\u7684\u662f\uff0c\u53d7\u6b64\u524d\u4e0a\u6d77\u65b0\u51a0\u75ab\u60c5\u5c01\u63a7\u5f71\u54cd\uff0c\u9488\u5bf9\u90e8\u5206\u60a3\u8005\u7684\u968f\u8bbf\u8bc4\u4f30\u5de5\u4f5c\u51fa\u73b0\u4e86\u5ef6\u8fdf\uff0c\u76ee\u524d\u5df2\u9010\u6b65\u6062\u590d\u3002\u516c\u53f8\u8ba1\u5212\u5728\u540e\u7eed\u7684\u5b66\u672f\u520a\u7269\u4e0a\u53d1\u8868\u5168\u4f53\u53d7\u8bd5\u8005\u66f4\u65b0\u7684\u7597\u6548\u6570\u636e\uff0c\u5305\u62ecDoR\u3001ORR\u4ee5\u53caBOR\u3002 2021\u5e7411\u6708\uff0cGC012F\u88ab\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002 \u53e3\u5934\u62a5\u544a\u56de\u987e\u8be6\u60c5\u5982\u4e0b\uff1a \u6458\u8981\u6807\u9898\uff1aBCMA\/CD19\u53cc\u9776\u70b9FasTCAR-T GC012F\u6cbb\u7597RRMM\u7684\u591a\u4e2d\u5fc3\u3001\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u7684\u6700\u65b0\u7814\u7a76\u7ed3\u679cAbstract title: Updated results of a multicenter first-in-human study of BCMA\/CD19 dual-targeting FasTCAR-T GC012F for patients with relapsed\/refractory multiple myeloma (RRMM) \u73af\u8282\u540d\u79f0\uff1a\u590d\u53d1\/\u96be\u6cbb\u6027\u9aa8\u9ad3\u7624\uff1aBCMA\u9776\u5411\u7597\u6cd5Session title: Relapsed\/refractory myeloma: BCMA-directed therapies 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More<\/a><\/p>\n","protected":false},"author":556,"featured_media":69391,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-69388","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/69388","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=69388"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/69388\/revisions"}],"predecessor-version":[{"id":69390,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/69388\/revisions\/69390"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/69391"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=69388"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=69388"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=69388"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}