{"id":69384,"date":"2022-06-13T06:45:00","date_gmt":"2022-06-12T23:45:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022061306450069384"},"modified":"2022-06-13T22:04:56","modified_gmt":"2022-06-13T14:04:56","slug":"%e3%80%90eha-2022%e3%80%91%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%af%e5%85%ac%e5%b8%83bcl-2%e6%8a%91%e5%88%b6%e5%89%82apg-2575%e6%b2%bb%e7%96%97%e4%b8%ad%e5%9b%bd%e5%a4%8d%e5%8f%91-%e9%9a%be%e6%b2%bb","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022061306450069384","title":{"rendered":"\u3010EHA 2022\u3011\u4e9a\u76db\u533b\u836f\u516c\u5e03Bcl-2\u6291\u5236\u5242APG-2575\u6cbb\u7597\u4e2d\u56fd\u590d\u53d1\/\u96be\u6cbb\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u79ef\u6781\u4e34\u5e8a\u6570\u636e"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02<\/span>2022\u5e746\u670813\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a — \u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u65e5\u524d\u57282022\u5e74\u6b27\u6d32\u8840\u6db2\u5b66\u534f\u4f1a\u5e74\u4f1a\uff08EHA 2022\uff09\u4e0a\u516c\u5e03\u4e86\u5728\u7814\u539f\u521b1\u7c7b\u65b0\u836fBcl-2\u9009\u62e9\u6027\u6291\u5236\u5242APG-2575\u6cbb\u7597\u4e2d\u56fd\u590d\u53d1\/\u96be\u6cbb\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624(r\/r NHL)\u60a3\u8005\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u3002<\/p>\n

\n<\/p><\/div>\n

\u4f5c\u4e3a\u6b27\u6d32\u8840\u6db2\u5b66\u9886\u57df\u89c4\u6a21\u6700\u5927\u7684\u56fd\u9645\u4f1a\u8bae\uff0cEHA\u5e74\u4f1a\u6bcf\u5e74\u90fd\u6709\u6765\u81ea\u5168\u7403100\u591a\u4e2a\u56fd\u5bb6\u768410000\u4f59\u540d\u4e13\u4e1a\u4eba\u58eb\u4e0e\u4f1a\uff0c\u5171\u540c\u5206\u4eab\u5e76\u63a2\u8ba8\u6709\u5173\u8840\u6db2\u5b66\u7684\u521b\u65b0\u7406\u5ff5\u53ca\u6700\u65b0\u7684\u79d1\u5b66\u548c\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u3002<\/p>\n

\u672c\u6b21\u5728EHA\u5e74\u4f1a\u5c55\u793a\u7684\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0cAPG-2575\u5728\u5242\u91cf\u722c\u5347\u81f3800mg\/\u5929\u65f6\u4ecd\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u672a\u89c2\u5bdf\u5230\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\uff08TLS\uff09\uff0c\u5728\u591a\u79cd\u590d\u53d1\u96be\u6cbb\u8840\u6db2\u80bf\u7624\uff0c\u5305\u62ec\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u3001\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff08MZL\uff09\u3001\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u4ee5\u53caT\u7ec6\u80deNHL\u4e2d\u5747\u5c55\u73b0\u51fa\u521d\u6b65\u7597\u6548\u3002\u572832\u4f8b\u53ef\u8bc4\u4f30\u60a3\u8005\u4e2d\u51714\u4f8b\u83b7\u5f97\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u30018\u4f8b\u83b7\u5f97\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u3002<\/p>\n

\u5176\u4e2d\u572811\u4f8b\u53ef\u8bc4\u4f30CLL\u60a3\u8005\u4e2d\uff08\u6240\u6709\u60a3\u8005\u5747\u5728\u524d\u671f\u63a5\u53d7\u8fc7\u91cd\u5ea6\u6cbb\u7597\u5305\u62ec\u514d\u75ab\u5316\u7597\u3001BTK\u6291\u5236\u5242\u7b49\uff0c\u4e14\u7edd\u5927\u591a\u6570\u60a3\u8005\u90fd\u5177\u6709\u81f3\u5c11\u4e00\u79cd\u9ad8\u5371\u9884\u540e\u56e0\u7d20\u5305\u62ec17p\u7f3a\u5931\/TP53\u7a81\u53d8\u548c\/\u6216\u5176\u5b83\uff09\uff0c200mg(\u542b)\u4ee5\u4e0a\u7684\u5242\u91cf\u7ec4\u67098\u4f8b\u53ef\u8bc4\u4f30\u60a3\u8005\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe\u523087.5%\uff0c\u4e3a3\u4f8bCR\u30014\u4f8bPR\u3002\u57286\u4f8b\u53ef\u8bc4\u4f30MCL\u60a3\u8005\u4e2d\uff0cORR\u4e3a33.3%\uff08\u5305\u62ec1\u4f8bCR\uff09\u3002\u57284\u4f8b\u53ef\u8bc4\u4f30MZL\u60a3\u8005\u4e2d\uff0cORR\u4e3a50%\u3002\u57283\u4f8b\u53ef\u8bc4\u4f30T\u7ec6\u80deNHL\u60a3\u8005\u4e2d\uff0cORR\u4e3a33.3%\u3002<\/p>\n

APG-2575\u662f\u4e9a\u76db\u533b\u836f\u81ea\u4e3b\u7814\u53d1\u7684Bcl-2\u9009\u62e9\u6027\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u901a\u8fc7\u9009\u62e9\u6027\u6291\u5236Bcl-2\u86cb\u767d\u6765\u6062\u590d\u80bf\u7624\u7ec6\u80de\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u673a\u5236\uff08\u7ec6\u80de\u51cb\u4ea1\uff09\uff0c\u4ece\u800c\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\uff0c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684\u3002APG-2575\u4e5f\u662f\u5168\u7403\u7b2c\u4e8c\u3001\u56fd\u5185\u9996\u4e2a\u8fdb\u5165\u5173\u952e\u6ce8\u518c\u4e34\u5e8a\u9636\u6bb5\u4e14\u5177\u6709\u660e\u786e\u7597\u6548\u7684Bcl-2\u9009\u62e9\u6027\u6291\u5236\u5242\uff0c\u6b63\u5728\u5168\u7403\u8303\u56f4\u5185\u5f00\u5c55\u6d89\u53ca\u591a\u4e2a\u8840\u6db2\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5448\u73b0\u5de8\u5927\u7684\u4e34\u5e8a\u5f00\u53d1\u6f5c\u529b\u3002<\/p>\n

\u672c\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u8840\u6db2\u75c5\u533b\u9662\uff08\u8840\u6db2\u5b66\u7814\u7a76\u6240\uff09\u526f\u6240\u9662\u957f\u738b\u5efa\u7965\u6559\u6388\u8868\u793a\uff1a"Bcl-2\u6291\u5236\u5242\u5728\u591a\u4e2a\u8840\u6db2\u80bf\u7624\u6cbb\u7597\u4e2d\u5177\u6709\u5de8\u5927\u6f5c\u529b\u3002APG-2575\u662f\u56fd\u5185\u7814\u53d1\u8fdb\u5c55\u6700\u5feb\u7684Bcl-2\u6291\u5236\u5242\uff0c\u5728\u524d\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5c55\u73b0\u4e86\u5f88\u597d\u7684"\u7597\u6548-\u5b89\u5168\u6027"\u7684\u5e73\u8861\uff0c\u800c\u4e14\u7528\u836f\u65b9\u6848\u4fbf\u6377\uff0c\u548c\u56fd\u5916\u540c\u7c7b\u836f\u7269\u76f8\u6bd4\u663e\u5f97\u72ec\u5177\u7279\u8272\u3002\u6211\u4eec\u671f\u5f85APG-2575\u8fd9\u4e2a\u56fd\u4ea7\u539f\u7814\u3001\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u65b0\u578bBcl-2\u6291\u5236\u5242\u80fd\u591f\u5c3d\u5feb\u83b7\u6279\u4e0a\u5e02\uff0c\u4e3a\u4e2d\u56fd\u60a3\u8005\u4e0e\u533b\u751f\u63d0\u4f9b\u66f4\u591a\u3001\u66f4\u597d\u7684\u6cbb\u7597\u9009\u62e9\u3002"<\/p>\n

\u8be5\u9879\u7814\u7a76\u7684\u4f1a\u8bae\u62a5\u544a\u4eba\u3001\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u8840\u6db2\u75c5\u533b\u9662\u5b59\u660e\u5a9b\u533b\u751f\u8868\u793a\uff1a"\u672c\u9879\u7814\u7a76\u5448\u73b0\u4e86APG-2575\u826f\u597d\u7684\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\uff0c\u4ee5\u53ca\u5728CLL\u4e0eMCL\u4e2d\u53ef\u89c2\u7684\u521d\u6b65\u7597\u6548\u3002\u76f8\u6bd4\u73b0\u6709\u7684Bcl-2\u6291\u5236\u5242\uff0cAPG-2575\u6bcf\u65e5\u5242\u91cf\u9012\u589e\u65b9\u6848\u53ef\u4ee5\u4e3a\u60a3\u8005\u63d0\u4f9b\u66f4\u4e3a\u65b9\u4fbf\u7684\u6cbb\u7597\u9009\u62e9\u3002"<\/p>\n

\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u8868\u793a\uff1a"APG-2575\u662f\u516c\u53f8\u5728\u7ec6\u80de\u51cb\u4ea1\u9886\u57df\u7684\u91cd\u8981\u5728\u7814\u54c1\u79cd\uff0c\u5728\u9488\u5bf9\u8840\u6db2\u80bf\u7624\u53ca\u5b9e\u4f53\u7624\u7684\u591a\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5c55\u73b0\u4e86\u5176\u826f\u597d\u7684\u8010\u53d7\u6027\u53ca\u6709\u6548\u6027\u3002\u6b64\u6b21\u6570\u636e\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86APG-2575\u5728r\/r NHL\u65b9\u9762\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u6211\u4eec\u671f\u5f85\u79ef\u6781\u63a8\u8fdbAPG-2575\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u52a0\u901f\u63a8\u5411\u5e02\u573a\uff0c\u4e3a\u6709\u9700\u8981\u7684\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002"<\/p>\n

APG-2575\u5728EHA 2022\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a<\/p>\n

Preliminary Results of a Phase 1 Study of Novel Bcl-2 Inhibitor Lisaftoclax (APG-2575) in Chinese Patients (pts) with Relapsed or Refractory (r\/r) Non-Hodgkin Lymphomas (NHLs)<\/b><\/p>\n

\u65b0\u578b<\/b>Bcl-2<\/b>\u6291\u5236\u5242<\/b>lisaftoclax (APG-2575)<\/b>\u6cbb\u7597\u4e2d\u56fd\u590d\u53d1<\/b>\/<\/b>\u96be\u6cbb\u6027<\/b>(r\/r)<\/b>\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624<\/b>(NHLs)<\/b>\u60a3\u8005\u7684<\/b>I<\/b>\u671f\u4e34\u5e8a\u8bd5\u9a8c\u521d\u6b65\u7ed3\u679c<\/b><\/p>\n

\u6458\u8981\u7f16\u53f7\uff1a<\/u> P1106<\/p>\n

\u6838\u5fc3\u8981\u70b9\uff1a<\/u><\/p>\n

    \n
  • \u8fd9\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5355\u836f\u5242\u91cf\u722c\u5761\u4e0e\u5242\u91cf\u9012\u589e\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u662fAPG-2575\u5728\u4e2d\u56fd\u7684\u9996\u4e2a\u4eba\u4f53\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30APG-2575\u5728\u4e2d\u56fdr\/r NHL\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u836f\u6548\u52a8\u529b\u5b66\u53ca\u521d\u6b65\u7597\u6548\u3002<\/li>\n
  • APG-2575\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\uff0c28\u5929\u4e3a\u4e00\u4e2a\u5468\u671f\u3002\u5728CLL\u6216\u4e2d\u3001\u9ad8TLS\u98ce\u9669\u7684NHL\u60a3\u8005\u4e2d\u91c7\u7528\u6bcf\u65e5\u5242\u91cf\u9012\u589e\u65b9\u6848\u3002<\/li>\n
  • \u622a\u81f32022\u5e741\u67081\u65e5\uff0c\u5171\u5165\u7ec440\u4f8b\u60a3\u8005\uff0c\u5305\u62ec12\u4f8bCLL\uff0c9\u4f8b\u6ee4\u6ce1\u6dcb\u5df4\u7624\uff08FL\uff09\u30017\u4f8bMCL\u30014\u4f8bMZL\u30014\u4f8bT\u7ec6\u80de\u6dcb\u5df4\u7624\u30012\u4f8b\u5f25\u6f2b\u6027\u5927B\u6dcb\u5df4\u7624\u4ee5\u53ca2\u4f8b\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff1b\u60a3\u8005\u63a5\u53d7\u4e8620~800mg\u5242\u91cf\u7684\u7ed9\u836f\uff0c\u76ee\u524d\u4ecd\u670920\u4f8b\u60a3\u8005\u5728\u7ec4\u3002<\/li>\n
  • \u4e2d\u4f4d\u6cbb\u7597\u65f6\u957f\u4e3a4\u4e2a\u5468\u671f\uff0c32\u4f8b\u53ef\u8bc4\u4f30\u60a3\u8005\u4e2d\u51714\u4f8b\u83b7\u5f97CR\u30018\u4f8b\u83b7\u5f97PR\uff08ORR 37.5%\uff09\u300211\u4f8b\u53ef\u8bc4\u4f30CLL\u60a3\u8005\u4e2d\uff0cORR\u4e3a 63.6%\uff0c3\u4f8bCR \uff0827.3%\uff09\uff0c4\u4f8bPR (36.4%)\uff0c\u5176\u4e2d\u5728\u2265 200 mg\u7684\u5242\u91cf\u7ec4\u4e2d\uff0cORR\u4e3a 87.5%\u3002\u57286\u4f8b\u53ef\u8bc4\u4f30MCL\u60a3\u8005\u4e2d\uff0c1\u4f8bCR\uff0c1\u4f8bPR\u3002\u57284\u4f8b\u53ef\u8bc4\u4f30MZL\u60a3\u8005\u4e2d\uff0c2\u4f8bPR\u3002\u57283\u4f8b\u53ef\u8bc4\u4f30T\u7ec6\u80deNHL\u60a3\u8005\u4e2d\uff0c1\u4f8bPR\u3002<\/li>\n
  • \u6cbb\u7597\u4e2d\u4e0d\u826f\u4e8b\u4ef6\uff08TEAEs\uff09\u591a\u6570\uff0867.5%\uff09\u4e3a1~2\u7ea7\uff0c\u8010\u53d7\u6027\u826f\u597d\u3002\u5728\u6240\u6709\u5242\u91cf\u7ec4\u5747\u672a\u89c2\u5bdf\u5230\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\uff0c\u4e5f\u6ca1\u6709\u89c2\u5bdf\u5230\u5b9e\u9a8c\u5ba4\u6216\u4e34\u5e8aTLS\u3002\u6ca1\u6709\u53d7\u8bd5\u8005\u56e0\u4e3a\u836f\u7269\u4e0d\u8010\u53d7\u800c\u53d1\u751f\u964d\u4f4e\u5242\u91cf\u6216\u9000\u51fa\u6cbb\u7597\u3002<\/li>\n<\/ul>\n

    \u7ed3\u8bba\uff1a<\/u><\/p>\n

    APG-2575\u5c55\u73b0\u51fa\u5f88\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5728CLL\/SLL\u548c MZL\u3001 MCL\u3001 T\u7ec6\u80deNHL\u7b49\u6dcb\u5df4\u7624\u4e9a\u578b\u4e2d\u663e\u73b0\u51fa\u826f\u597d\u6cbb\u7597\u53cd\u5e94\u3002APG-2575\u5b89\u5168\u6027\u51fa\u8272\uff0cAPG-2575\u5242\u91cf\u4ece20mg\/\u5929\u722c\u5347\u81f3800mg\/\u5929\u5747\u672a\u89c2\u5bdf\u5230DLT\uff0c\u4e5f\u6ca1\u6709\u89c2\u5bdf\u5230TLS\u3002<\/p>\n

    \u5173\u4e8e\u4e9a\u76db\u533b\u836f\uff08<\/u><\/b>6855.HK\uff09<\/u><\/b><\/p>\n

    \u4e9a\u76db\u533b\u836f\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u56fd\u3001\u9762\u5411\u5168\u7403\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\uff0c\u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u7684\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9a\u76db\u533b\u836f\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u4e3b\u677f\u6302\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a6855.HK\u3002<\/p>\n

    \u4e9a\u76db\u533b\u836f\u62e5\u6709\u81ea\u4e3b\u6784\u5efa\u7684\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u9776\u5411\u836f\u7269\u8bbe\u8ba1\u5e73\u53f0\uff0c\u5904\u4e8e\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u65b0\u836f\u7814\u53d1\u7684\u5168\u7403\u6700\u524d\u6cbf\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u62e5\u67098\u4e2a\u5df2\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u76841\u7c7b\u5c0f\u5206\u5b50\u65b0\u836f\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216 MDM2-p53 \u7b49\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u5173\u952e\u86cb\u767d\u7684\u6291\u5236\u5242\uff1b\u65b0\u4e00\u4ee3\u9488\u5bf9\u764c\u75c7\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u6fc0\u9176\u7a81\u53d8\u4f53\u7684\u6291\u5236\u5242\u7b49\uff0c\u4e3a\u5168\u7403\u552f\u4e00\u5728\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u5173\u952e\u86cb\u767d\u9886\u57df\u5747\u6709\u4e34\u5e8a\u5f00\u53d1\u54c1\u79cd\u7684\u521b\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u53ca\u6b27\u6d32\u5f00\u5c5550\u591a\u9879I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u7528\u4e8e\u6cbb\u7597\u8010\u836f\u6027\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u79cd\u5965\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\uff09\u66fe\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u65b0\u836f\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u548c\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\uff0c\u5e76\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u4e2a\u4e0a\u5e02\u54c1\u79cd\u3002\u8be5\u54c1\u79cd\u8fd8\u83b7\u5f97\u4e86\u7f8e\u56fdFDA\u5feb\u901f\u901a\u9053\u8d44\u683c\u3001\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3001\u4ee5\u53ca\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002\u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u4e2a\u5728\u7814\u65b0\u836f\u83b7\u5f9715\u9879FDA\u548c1\u9879\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c2\u9879FDA\u5feb\u901f\u901a\u9053\u8d44\u683c\u4ee5\u53ca2\u9879FDA\u513f\u7ae5\u7f55\u89c1\u75c5\u8d44\u683c\u8ba4\u8bc1\u3002\u516c\u53f8\u5148\u540e\u627f\u62c5\u591a\u9879\u56fd\u5bb6\u79d1\u6280\u91cd\u5927\u4e13\u9879\uff0c\u5176\u4e2d"\u91cd\u5927\u65b0\u836f\u521b\u5236"\u4e13\u98795\u9879\uff0c\u5305\u62ec1\u9879"\u4f01\u4e1a\u521b\u65b0\u836f\u7269\u5b75\u5316\u57fa\u5730"\u53ca4\u9879"\u521b\u65b0\u836f\u7269\u7814\u53d1"\uff0c\u53e6\u5916\u627f\u62c5"\u91cd\u5927\u4f20\u67d3\u75c5\u9632\u6cbb"\u4e13\u98791\u9879\u3002<\/p>\n

    \u51ed\u501f\u5f3a\u5927\u7684\u7814\u53d1\u80fd\u529b\uff0c\u4e9a\u76db\u533b\u836f\u5df2\u5728\u5168\u7403\u8303\u56f4\u5185\u8fdb\u884c\u77e5\u8bc6\u4ea7\u6743\u5e03\u5c40\uff0c\u5e76\u4e0eUNITY\u3001MD Anderson\u3001\u6885\u5965\u533b\u5b66\u4e2d\u5fc3\u548cDana-Farber\u764c\u75c7\u7814\u7a76\u6240\u3001\u9ed8\u6c99\u4e1c\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f89\u745e\u7b49\u9886\u5148\u7684\u751f\u7269\u6280\u672f\u53ca\u533b\u836f\u516c\u53f8\u3001\u5b66\u672f\u673a\u6784\u8fbe\u6210\u5168\u7403\u5408\u4f5c\u5173\u7cfb\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u4e00\u652f\u5177\u6709\u4e30\u5bcc\u7684\u539f\u521b\u65b0\u836f\u7814\u53d1\u4e0e\u4e34\u5e8a\u5f00\u53d1\u7ecf\u9a8c\u7684\u56fd\u9645\u5316\u4eba\u624d\u56e2\u961f\uff0c\u540c\u65f6\uff0c\u516c\u53f8\u6b63\u5728\u9ad8\u6807\u51c6\u6253\u9020\u540e\u671f\u7684\u5546\u4e1a\u5316\u751f\u4ea7\u53ca\u5e02\u573a\u8425\u9500\u56e2\u961f\u3002\u4e9a\u76db\u533b\u836f\u5c06\u4e0d\u65ad\u63d0\u9ad8\u7814\u53d1\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u8fdb\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u7684\u4e34\u5e8a\u5f00\u53d1\u8fdb\u5ea6\uff0c\u771f\u6b63\u8df5\u884c"\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42"\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002<\/p>\n

    \u524d\u77bb\u6027\u58f0\u660e<\/u><\/b><\/p>\n

    \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9648\u8ff0\u4ec5\u4e0e\u672c\u6587\u4f5c\u51fa\u8be5\u9648\u8ff0\u5f53\u65e5\u7684\u4e8b\u4ef6\u6216\u8d44\u6599\u6709\u5173\u3002\u9664\u6cd5\u5f8b\u89c4\u5b9a\u5916\uff0c\u4e8e\u4f5c\u51fa\u524d\u77bb\u6027\u9648\u8ff0\u5f53\u65e5\u4e4b\u540e\uff0c\u65e0\u8bba\u662f\u5426\u51fa\u73b0\u65b0\u8d44\u6599\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u51b5\uff0c\u6211\u4eec\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u6216\u516c\u5f00\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u53ca\u9884\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8bf7\u7ec6\u9605\u672c\u6587\uff0c\u5e76\u7406\u89e3\u6211\u4eec\u7684\u5b9e\u9645\u672a\u6765\u4e1a\u7ee9\u6216\u8868\u73b0\u53ef\u80fd\u4e0e\u9884\u671f\u6709\u91cd\u5927\u5dee\u5f02\u3002\u672c\u6587\u5185\u6240\u6709\u9648\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u53d1\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u6765\u53d1\u5c55\u800c\u51fa\u73b0\u53d8\u52a8\u3002<\/p>\n

     <\/p>\n

    <\/div>\n","protected":false},"excerpt":{"rendered":"

    \u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e022022\u5e746\u670813\u65e5 \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a — \u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u65e5\u524d\u57282022\u5e74\u6b27\u6d32\u8840\u6db2\u5b66\u534f\u4f1a\u5e74\u4f1a\uff08EHA 2022\uff09\u4e0a\u516c\u5e03\u4e86\u5728\u7814\u539f\u521b1\u7c7b\u65b0\u836fBcl-2\u9009\u62e9\u6027\u6291\u5236\u5242APG-2575\u6cbb\u7597\u4e2d\u56fd\u590d\u53d1\/\u96be\u6cbb\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624(r\/r NHL)\u60a3\u8005\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u3002 \u4f5c\u4e3a\u6b27\u6d32\u8840\u6db2\u5b66\u9886\u57df\u89c4\u6a21\u6700\u5927\u7684\u56fd\u9645\u4f1a\u8bae\uff0cEHA\u5e74\u4f1a\u6bcf\u5e74\u90fd\u6709\u6765\u81ea\u5168\u7403100\u591a\u4e2a\u56fd\u5bb6\u768410000\u4f59\u540d\u4e13\u4e1a\u4eba\u58eb\u4e0e\u4f1a\uff0c\u5171\u540c\u5206\u4eab\u5e76\u63a2\u8ba8\u6709\u5173\u8840\u6db2\u5b66\u7684\u521b\u65b0\u7406\u5ff5\u53ca\u6700\u65b0\u7684\u79d1\u5b66\u548c\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u3002 \u672c\u6b21\u5728EHA\u5e74\u4f1a\u5c55\u793a\u7684\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0cAPG-2575\u5728\u5242\u91cf\u722c\u5347\u81f3800mg\/\u5929\u65f6\u4ecd\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u672a\u89c2\u5bdf\u5230\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\uff08TLS\uff09\uff0c\u5728\u591a\u79cd\u590d\u53d1\u96be\u6cbb\u8840\u6db2\u80bf\u7624\uff0c\u5305\u62ec\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u3001\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff08MZL\uff09\u3001\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u4ee5\u53caT\u7ec6\u80deNHL\u4e2d\u5747\u5c55\u73b0\u51fa\u521d\u6b65\u7597\u6548\u3002\u572832\u4f8b\u53ef\u8bc4\u4f30\u60a3\u8005\u4e2d\u51714\u4f8b\u83b7\u5f97\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u30018\u4f8b\u83b7\u5f97\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u3002 \u5176\u4e2d\u572811\u4f8b\u53ef\u8bc4\u4f30CLL\u60a3\u8005\u4e2d\uff08\u6240\u6709\u60a3\u8005\u5747\u5728\u524d\u671f\u63a5\u53d7\u8fc7\u91cd\u5ea6\u6cbb\u7597\u5305\u62ec\u514d\u75ab\u5316\u7597\u3001BTK\u6291\u5236\u5242\u7b49\uff0c\u4e14\u7edd\u5927\u591a\u6570\u60a3\u8005\u90fd\u5177\u6709\u81f3\u5c11\u4e00\u79cd\u9ad8\u5371\u9884\u540e\u56e0\u7d20\u5305\u62ec17p\u7f3a\u5931\/TP53\u7a81\u53d8\u548c\/\u6216\u5176\u5b83\uff09\uff0c200mg(\u542b)\u4ee5\u4e0a\u7684\u5242\u91cf\u7ec4\u67098\u4f8b\u53ef\u8bc4\u4f30\u60a3\u8005\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe\u523087.5%\uff0c\u4e3a3\u4f8bCR\u30014\u4f8bPR\u3002\u57286\u4f8b\u53ef\u8bc4\u4f30MCL\u60a3\u8005\u4e2d\uff0cORR\u4e3a33.3%\uff08\u5305\u62ec1\u4f8bCR\uff09\u3002\u57284\u4f8b\u53ef\u8bc4\u4f30MZL\u60a3\u8005\u4e2d\uff0cORR\u4e3a50%\u3002\u57283\u4f8b\u53ef\u8bc4\u4f30T\u7ec6\u80deNHL\u60a3\u8005\u4e2d\uff0cORR\u4e3a33.3%\u3002 APG-2575\u662f\u4e9a\u76db\u533b\u836f\u81ea\u4e3b\u7814\u53d1\u7684Bcl-2\u9009\u62e9\u6027\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u901a\u8fc7\u9009\u62e9\u6027\u6291\u5236Bcl-2\u86cb\u767d\u6765\u6062\u590d\u80bf\u7624\u7ec6\u80de\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u673a\u5236\uff08\u7ec6\u80de\u51cb\u4ea1\uff09\uff0c\u4ece\u800c\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\uff0c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684\u3002APG-2575\u4e5f\u662f\u5168\u7403\u7b2c\u4e8c\u3001\u56fd\u5185\u9996\u4e2a\u8fdb\u5165\u5173\u952e\u6ce8\u518c\u4e34\u5e8a\u9636\u6bb5\u4e14\u5177\u6709\u660e\u786e\u7597\u6548\u7684Bcl-2\u9009\u62e9\u6027\u6291\u5236\u5242\uff0c\u6b63\u5728\u5168\u7403\u8303\u56f4\u5185\u5f00\u5c55\u6d89\u53ca\u591a\u4e2a\u8840\u6db2\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5448\u73b0\u5de8\u5927\u7684\u4e34\u5e8a\u5f00\u53d1\u6f5c\u529b\u3002 \u672c\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u8840\u6db2\u75c5\u533b\u9662\uff08\u8840\u6db2\u5b66\u7814\u7a76\u6240\uff09\u526f\u6240\u9662\u957f\u738b\u5efa\u7965\u6559\u6388\u8868\u793a\uff1a"Bcl-2\u6291\u5236\u5242\u5728\u591a\u4e2a\u8840\u6db2\u80bf\u7624\u6cbb\u7597\u4e2d\u5177\u6709\u5de8\u5927\u6f5c\u529b\u3002APG-2575\u662f\u56fd\u5185\u7814\u53d1\u8fdb\u5c55\u6700\u5feb\u7684Bcl-2\u6291\u5236\u5242\uff0c\u5728\u524d\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5c55\u73b0\u4e86\u5f88\u597d\u7684"\u7597\u6548-\u5b89\u5168\u6027"\u7684\u5e73\u8861\uff0c\u800c\u4e14\u7528\u836f\u65b9\u6848\u4fbf\u6377\uff0c\u548c\u56fd\u5916\u540c\u7c7b\u836f\u7269\u76f8\u6bd4\u663e\u5f97\u72ec\u5177\u7279\u8272\u3002\u6211\u4eec\u671f\u5f85APG-2575\u8fd9\u4e2a\u56fd\u4ea7\u539f\u7814\u3001\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u65b0\u578bBcl-2\u6291\u5236\u5242\u80fd\u591f\u5c3d\u5feb\u83b7\u6279\u4e0a\u5e02\uff0c\u4e3a\u4e2d\u56fd\u60a3\u8005\u4e0e\u533b\u751f\u63d0\u4f9b\u66f4\u591a\u3001\u66f4\u597d\u7684\u6cbb\u7597\u9009\u62e9\u3002" \u8be5\u9879\u7814\u7a76\u7684\u4f1a\u8bae\u62a5\u544a\u4eba\u3001\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u8840\u6db2\u75c5\u533b\u9662\u5b59\u660e\u5a9b\u533b\u751f\u8868\u793a\uff1a"\u672c\u9879\u7814\u7a76\u5448\u73b0\u4e86APG-2575\u826f\u597d\u7684\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\uff0c\u4ee5\u53ca\u5728CLL\u4e0eMCL\u4e2d\u53ef\u89c2\u7684\u521d\u6b65\u7597\u6548\u3002\u76f8\u6bd4\u73b0\u6709\u7684Bcl-2\u6291\u5236\u5242\uff0cAPG-2575\u6bcf\u65e5\u5242\u91cf\u9012\u589e\u65b9\u6848\u53ef\u4ee5\u4e3a\u60a3\u8005\u63d0\u4f9b\u66f4\u4e3a\u65b9\u4fbf\u7684\u6cbb\u7597\u9009\u62e9\u3002" \u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u8868\u793a\uff1a"APG-2575\u662f\u516c\u53f8\u5728\u7ec6\u80de\u51cb\u4ea1\u9886\u57df\u7684\u91cd\u8981\u5728\u7814\u54c1\u79cd\uff0c\u5728\u9488\u5bf9\u8840\u6db2\u80bf\u7624\u53ca\u5b9e\u4f53\u7624\u7684\u591a\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5c55\u73b0\u4e86\u5176\u826f\u597d\u7684\u8010\u53d7\u6027\u53ca\u6709\u6548\u6027\u3002\u6b64\u6b21\u6570\u636e\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86APG-2575\u5728r\/r NHL\u65b9\u9762\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u6211\u4eec\u671f\u5f85\u79ef\u6781\u63a8\u8fdbAPG-2575\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u52a0\u901f\u63a8\u5411\u5e02\u573a\uff0c\u4e3a\u6709\u9700\u8981\u7684\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002" APG-2575\u5728EHA 2022\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a Preliminary Results of a Phase 1 Study of Novel Bcl-2 Inhibitor Lisaftoclax (APG-2575) in Chinese Patients (pts) with Relapsed or Refractory (r\/r) Non-Hodgkin Lymphomas (NHLs) \u65b0\u578bBcl-2\u6291\u5236\u5242lisaftoclax (APG-2575)\u6cbb\u7597\u4e2d\u56fd\u590d\u53d1\/\u96be\u6cbb\u6027(r\/r)\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624(NHLs)\u60a3\u8005\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u521d\u6b65\u7ed3\u679c \u6458\u8981\u7f16\u53f7\uff1a P1106 \u6838\u5fc3\u8981\u70b9\uff1a \u8fd9\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5355\u836f\u5242\u91cf\u722c\u5761\u4e0e\u5242\u91cf\u9012\u589e\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u662fAPG-2575\u5728\u4e2d\u56fd\u7684\u9996\u4e2a\u4eba\u4f53\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30APG-2575\u5728\u4e2d\u56fdr\/r NHL\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u836f\u6548\u52a8\u529b\u5b66\u53ca\u521d\u6b65\u7597\u6548\u3002 APG-2575\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\uff0c28\u5929\u4e3a\u4e00\u4e2a\u5468\u671f\u3002\u5728CLL\u6216\u4e2d\u3001\u9ad8TLS\u98ce\u9669\u7684NHL\u60a3\u8005\u4e2d\u91c7\u7528\u6bcf\u65e5\u5242\u91cf\u9012\u589e\u65b9\u6848\u3002 \u622a\u81f32022\u5e741\u67081\u65e5\uff0c\u5171\u5165\u7ec440\u4f8b\u60a3\u8005\uff0c\u5305\u62ec12\u4f8bCLL\uff0c9\u4f8b\u6ee4\u6ce1\u6dcb\u5df4\u7624\uff08FL\uff09\u30017\u4f8bMCL\u30014\u4f8bMZL\u30014\u4f8bT\u7ec6\u80de\u6dcb\u5df4\u7624\u30012\u4f8b\u5f25\u6f2b\u6027\u5927B\u6dcb\u5df4\u7624\u4ee5\u53ca2\u4f8b\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff1b\u60a3\u8005\u63a5\u53d7\u4e8620~800mg\u5242\u91cf\u7684\u7ed9\u836f\uff0c\u76ee\u524d\u4ecd\u670920\u4f8b\u60a3\u8005\u5728\u7ec4\u3002 \u4e2d\u4f4d\u6cbb\u7597\u65f6\u957f\u4e3a4\u4e2a\u5468\u671f\uff0c32\u4f8b\u53ef\u8bc4\u4f30\u60a3\u8005\u4e2d\u51714\u4f8b\u83b7\u5f97CR\u30018\u4f8b\u83b7\u5f97PR\uff08ORR 37.5%\uff09\u300211\u4f8b\u53ef\u8bc4\u4f30CLL\u60a3\u8005\u4e2d\uff0cORR\u4e3a 63.6%\uff0c3\u4f8bCR \uff0827.3%\uff09\uff0c4\u4f8bPR… Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":69387,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-69384","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/69384","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=69384"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/69384\/revisions"}],"predecessor-version":[{"id":69386,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/69384\/revisions\/69386"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/69387"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=69384"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=69384"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=69384"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}