{"id":69374,"date":"2022-06-13T07:00:00","date_gmt":"2022-06-13T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022061307000069374"},"modified":"2022-06-13T21:51:48","modified_gmt":"2022-06-13T13:51:48","slug":"%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%9c%a8%e7%be%8e%e5%9b%bd%e5%86%85%e5%88%86%e6%b3%8c%e5%b9%b4%e4%bc%9aendo-2022%e5%85%ac%e5%b8%83mazdutideibi362%e5%9c%a8%e4%b8%ad%e5%9b%bd%e8%82%a5%e8%83%96","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022061307000069374","title":{"rendered":"\u4fe1\u8fbe\u751f\u7269\u5728\u7f8e\u56fd\u5185\u5206\u6ccc\u5e74\u4f1a(ENDO 2022)\u516c\u5e03mazdutide(IBI362)\u5728\u4e2d\u56fd\u80a5\u80d6\u6216\u8d85\u91cd\u60a3\u8005\u4e2d\u7684Ib\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u9ad8\u5242\u91cf\u961f\u5217\u7ed3\u679c"},"content":{"rendered":"<p><p><span class=\"legendSpanClass\">\u7f8e\u56fd\u65e7\u91d1\u5c71\u548c\u4e2d\u56fd\u82cf\u5dde<\/span><span 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\u7684mazdutide\u6216\u5b89\u6170\u5242\u7684\u5242\u91cf\u6ef4\u5b9a\uff0c\u6bcf\u5468\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\uff0c\u6bcf\u4e2a\u5242\u91cf\u6c34\u5e73\u8fde\u7eed\u7ed9\u836f4\u5468\u3002\u961f\u52174\u5171\u7ed9\u836f16\u5468\uff0c\u5176\u4f59\u961f\u5217\u5171\u7ed9\u836f12\u5468\u3002<\/p>\n<ul type=\"disc\">\n<li>\u5728\u4f4e\u5242\u91cf\u961f\u5217\uff08\u961f\u52171-3\uff09\uff0cmazdutide\u5c55\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u53ca\u5b89\u5168\u6027\uff0c\u5e73\u5747\u4f53\u91cd\u81ea\u57fa\u7ebf\u767e\u5206\u6bd4\u964d\u5e45\u6700\u9ad8\u8fbe6.4%\uff0c\u53d7\u8bd5\u8005\u7684BMI\u548c\u8170\u56f4\uff0c\u4ee5\u53ca\u8840\u538b\u3001\u8840\u8102\u548c\u8840\u5c3f\u9178\u7b49\u4ee3\u8c22\u6307\u6807\u4e0d\u540c\u7a0b\u5ea6\u6539\u5584\uff0c\u4ee5\u4e0a\u961f\u5217\u6570\u636e\u5df2\u53d1\u8868\u4e8e\u67f3\u53f6\u5200\u5b50\u520a<i>EClinicalMedicine<\/i><span id=\"spanHghlt08f7\"><sup>&nbsp;[<\/sup><sup>1]<\/sup><\/span>\u3002<\/li>\n<li>\u672c\u6b21ENDO\u5927\u4f1a\u9996\u6b21\u62ab\u9732\u9ad8\u5242\u91cf\u961f\u5217\uff08\u961f\u52174\u548c5\uff09\u7684\u6570\u636e\u3002\u5728\u9ad8\u5242\u91cf\u961f\u5217\u4e2d\uff0cmazdutide\u6ef4\u5b9a\u81f310 mg\u548c9 mg\u5c55\u73b0\u51fa\u4e0e\u4f4e\u5242\u91cf\u961f\u5217\u76f8\u4f3c\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002\u65e0\u53d7\u8bd5\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u9000\u51fa\u7814\u7a76\u3002\u65e0\u53d7\u8bd5\u8005\u8fdb\u884c\u7814\u7a76\u836f\u7269\u5242\u91cf\u8c03\u6574\u3002\u672a\u53d1\u751f\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002<\/li>\n<li>\u8fde\u7eed\u7ed9\u836f16\u5468\u540e\uff0c\u961f\u52174\u4e2d\u63a5\u53d7mazdutide\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u5e73\u5747\u4f53\u91cd\u8f83\u57fa\u7ebf\u4e0b\u964d7.62 kg\uff08\u767e\u5206\u6bd4\u964d\u5e459.5%\uff09\uff1b\u8fde\u7eed\u7528\u836f12\u5468\u540e\uff0c\u961f\u52175\u4e2d\u63a5\u53d7mazdutide\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u5e73\u5747\u4f53\u91cd\u8f83\u57fa\u7ebf\u4e0b\u964d9.23 kg\uff08\u767e\u5206\u6bd4\u964d\u5e4511.7%\uff09\u3002\u961f\u52174\u548c\u961f\u52175\u4e2d\u5404\u67094\u4f8b\u53d7\u8bd5\u8005\uff0850%\uff09\u4f53\u91cd\u81ea\u57fa\u7ebf\u767e\u5206\u6bd4\u964d\u5e45\u8d85\u8fc710%\uff0c\u5404\u67092\u4f8b\u53d7\u8bd5\u8005\uff0825%\uff09\u4f53\u91cd\u81ea\u57fa\u7ebf\u767e\u5206\u6bd4\u964d\u5e45\u8d85\u8fc715%\u3002\u63a5\u53d7mazdutide\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u7684BMI\u548c\u8170\u56f4\uff0c\u4ee5\u53ca\u8840\u538b\u3001\u8840\u8102\u548c\u8840\u5c3f\u9178\u7b49\u4ee3\u8c22\u6307\u6807\u7684\u6539\u5584\u4e0e\u4f4e\u5242\u91cf\u961f\u5217\u4e2d\u89c2\u5bdf\u5230\u7684\u8d8b\u52bf\u4e00\u81f4\u3002<\/li>\n<\/ul>\n<p><b>\u8be5\u9879\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662\u7eaa\u7acb\u519c\u6559\u6388<\/b>\u8868\u793a\uff1a&quot;\u4e2d\u56fd\u80a5\u80d6\u4eba\u7fa4\u8d85\u8fc71\u4ebf\uff0c\u5927\u90e8\u5206\u60a3\u8005\u4e0d\u80fd\u901a\u8fc7\u751f\u6d3b\u65b9\u5f0f\u5e72\u9884\u8fbe\u5230\u51cf\u91cd\u76ee\u6807\uff0c\u4e9f\u9700\u5b89\u5168\u4e14\u6709\u6548\u7684\u51cf\u91cd\u836f\u7269\u3002\u6211\u4eec\u5f88\u6b23\u559c\u5730\u770b\u5230\uff0c\u5728\u4f4e\u5242\u91cf\u826f\u597d\u5b89\u5168\u6027\u548c\u663e\u8457\u51cf\u91cd\u7597\u6548\u7684\u57fa\u7840\u4e0a\uff0c\u9ad8\u5242\u91cfmazdutide\u5c55\u73b0\u51fa\u540c\u7b49\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\u3001\u66f4\u52a0\u5f3a\u5927\u7684\u51cf\u91cd\u7597\u6548\u4ee5\u53ca\u4ee3\u8c22\u6307\u6807\u7684\u591a\u91cd\u83b7\u76ca\uff0c\u6709\u671b\u4e3a\u91cd\u5ea6\u80a5\u80d6\u60a3\u8005\u5e26\u6765\u4e0e\u51cf\u91cd\u624b\u672f\u7597\u6548\u76f8\u5ab2\u7f8e\u7684\u6cbb\u7597\u9009\u62e9\u3002\u57fa\u4e8e\u5f53\u524d\u7d2f\u79ef\u7684\u4e34\u5e8a\u6570\u636e\u4ee5\u53ca\u7814\u53d1\u8fdb\u5ea6\uff0c\u6709\u7406\u7531\u76f8\u4fe1mazdutide 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id=\"spanHghlt48fe\">\u51cf\u91cd\u5355\u836f<\/span>\u79cd\u552f\u4e00\u51cf\u91cd\u5e45\u5ea6\u5728\u7ed9\u836f12\u5468\u5373\u8d85\u8fc711.5%\u7684\u5206\u5b50\u3002\u8be5\u7ed3\u679c\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86GLP-1R\u548cGCGR\u53cc\u6fc0\u52a8\u5242\u76f8\u8f83\u4e8eGLP-1R\u5355\u9776\u70b9\u6fc0\u52a8\u5242\u5728\u51cf\u91cd\u7597\u6548\u65b9\u9762\u7684\u4f18\u52bf\u3002\u540c\u65f6\uff0cmazdutide\u5728\u8d85\u91cd\u6216\u80a5\u80d6\u60a3\u8005\u4e2d\u5e26\u6765\u7684\u591a\u91cd\u4ee3\u8c22\u83b7\u76ca\u4e5f\u8fdb\u4e00\u6b65\u5f97\u5230\u9a8c\u8bc1\u3002\u6211\u4eec\u5c06\u7ee7\u7eed\u63a8\u8fdb\u9ad8\u5242\u91cfmazdutide\u5728\u4e2d\u56fd\u8d85\u91cd\u6216\u80a5\u80d6\u7b49\u9002\u5e94\u75c7\u4e2d\u7684\u8fdb\u4e00\u6b65\u4e34\u5e8a\u7814\u7a76\uff0c\u76f8\u4fe1\u80fd\u83b7\u5f97\u66f4\u52a0\u4ee4\u4eba\u6b23\u559c\u7684\u7ed3\u679c\u3002&quot;<\/p>\n<p><sup><span id=\"spanHghlt4793\">[1]<\/span><\/sup>Ji L, Jiang H, An P, et al. (2021) IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose phase <span class=\"xn-money\">1b<\/span> study. <i>EClinicalMedicine<\/i> 39: 101088. 10.1016\/j.eclinm.2021.101088<\/p>\n<p><b>\u5173\u4e8e\u80a5\u80d6<\/b><\/p>\n<p>\u6211\u56fd\u662f\u5168\u7403\u80a5\u80d6\u4eba\u53e3\u6700\u591a\u7684\u56fd\u5bb6\uff0c\u4e14\u5448\u73b0\u9010\u6e10\u4e0a\u5347\u8d8b\u52bf\u3002\u80a5\u80d6\u53ef\u4ee5\u5bfc\u81f4\u4e00\u7cfb\u5217\u5e76\u53d1\u75c7\u6216\u8005\u76f8\u5173\u75be\u75c5\uff0c\u8fdb\u800c\u5f71\u54cd\u9884\u671f\u5bff\u547d\u6216\u8005\u5bfc\u81f4\u751f\u6d3b\u8d28\u91cf\u4e0b\u964d\u3002\u5728\u8f83\u4e3a\u4e25\u91cd\u7684\u80a5\u80d6\u60a3\u8005\u4e2d\uff0c\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u548c\u67d0\u4e9b\u80bf\u7624\u7684\u53d1\u751f\u7387\u53ca\u6b7b\u4ea1\u7387\u660e\u663e\u4e0a\u5347\u3002\u80a5\u80d6\u75c7\u662f\u9700\u8981\u957f\u671f\u6cbb\u7597\u7684\u6162\u6027\u75be\u75c5\uff0c\u76ee\u524d\u7f3a\u4e4f\u957f\u671f\u6709\u6548\u4e14\u5b89\u5168\u7684\u6cbb\u7597\u624b\u6bb5\u3002\u751f\u6d3b\u65b9\u5f0f\u5e72\u9884\u662f\u8d85\u91cd\u6216\u80a5\u80d6\u8005\u7684\u9996\u9009\u548c\u57fa\u7840\u6cbb\u7597\u624b\u6bb5\uff0c\u4f46\u662f\u4ecd\u6709\u76f8\u5f53\u4e00\u90e8\u5206\u60a3\u8005\u7531\u4e8e\u79cd\u79cd\u539f\u56e0\u4e0d\u80fd\u8fbe\u5230\u671f\u671b\u7684\u51cf\u91cd\u76ee\u6807\uff0c\u9700\u7528\u836f\u7269\u8f85\u52a9\u51cf\u91cd\u3002\u4f20\u7edf\u51cf\u80a5\u836f\u51cf\u91cd\u6548\u679c\u6709\u9650\uff0c\u4e14\u5b58\u5728\u5b89\u5168\u95ee\u9898\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b> Mazdutide\uff08IBI362\uff09<\/b><\/p>\n<p>Mazdutide\uff08IBI362\uff09\u662f\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u4e0e\u793c\u6765\u5236\u836f\u5171\u540c\u63a8\u8fdb\u7684\u4e00\u6b3e\u80c3\u6ccc\u9178\u8c03\u8282\u7d20\u521b\u65b0\u5316\u5408\u7269\uff08OXM3\uff09\uff0c\u5728\u540c\u7c7b\u4ea7\u54c1\u4e2d\u5177\u6709\u6700\u4f18\u6f5c\u529b\u3002\u4f5c\u4e3a\u4e00\u79cd\u4e0e\u54fa\u4e73\u52a8\u7269\u80c3\u6ccc\u9178\u8c03\u8282\u7d20\u7c7b\u4f3c\u7684\u957f\u6548\u5408\u6210\u80bd\uff0cmazdutide\u5229\u7528\u8102\u80aa\u9170\u57fa\u4fa7\u94fe\u5ef6\u957f\u4f5c\u7528\u65f6\u95f4\uff0c\u5141\u8bb8\u6bcf\u5468\u7ed9\u836f\u4e00\u6b21\u3002Mazdutide\u7684\u4f5c\u7528\u88ab\u8ba4\u4e3a\u662f\u901a\u8fc7GLP-1R\u548cGCGR\u7684\u7ed3\u5408\u548c\u6fc0\u6d3b\u4ecb\u5bfc\u7684\uff0c\u4e0eOXM\u5177\u6709\u76f8\u4f3c\u4f5c\u7528\u673a\u5236\uff0c\u56e0\u6b64\u9884\u8ba1\u5176\u53ef\u4ee5\u6539\u5584\u8461\u8404\u7cd6\u8010\u91cf\u5e76\u51cf\u8f7b\u4f53\u91cd\u3002\u9664\u4e86GLP-1R\u6fc0\u52a8\u5242\u5177\u6709\u7684\u4fc3\u8fdb\u80f0\u5c9b\u7d20\u5206\u6ccc\u3001\u964d\u4f4e\u8840\u7cd6\u548c\u51cf\u8f7b\u4f53\u91cd\u7b49\u4f5c\u7528\u5916\uff0cmazdutide\u8fd8\u53ef\u80fd\u901a\u8fc7GCGR\u7684\u6fc0\u6d3b\u5177\u6709\u589e\u52a0\u80fd\u91cf\u6d88\u8017\u548c\u6539\u5584\u809d\u810f\u8102\u80aa\u4ee3\u8c22\u7b49\u6548\u5e94\u3002\u901a\u8fc7\u5f00\u53d1\u540c\u65f6\u6fc0\u52a8\u591a\u4e2a\u4e0e\u4ee3\u8c22\u76f8\u5173\u7684\u9776\u70b9\u6765\u6cbb\u7597\u4ee3\u8c22\u6027\u75be\u75c5\u662f\u76ee\u524d\u56fd\u9645\u4e0a\u65b0\u836f\u7814\u53d1\u6700\u65b0\u7684\u8d8b\u52bf\u3002<\/p>\n<p><b>\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n<p>&quot;\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c&quot;\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u7406\u60f3\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u7684\u521b\u65b0\u836f\u7269\u30022018\u5e7410\u670831\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a01801\u3002<\/p>\n<p>\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u516c\u53f8\u51ed\u501f\u521b\u65b0\u6210\u679c\u548c\u56fd\u9645\u5316\u7684\u8fd0\u8425\u6a21\u5f0f\u5728\u4f17\u591a\u751f\u7269\u5236\u836f\u516c\u53f8\u4e2d\u8131\u9896\u800c\u51fa\u3002\u5efa\u7acb\u8d77\u4e86\u4e00\u6761\u5305\u62ec32\u4e2a\u65b0\u836f\u54c1\u79cd\u7684\u4ea7\u54c1\u94fe\uff0c\u8986\u76d6\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u591a\u4e2a\u75be\u75c5\u9886\u57df\uff0c\u5176\u4e2d7\u4e2a\u54c1\u79cd\u5165\u9009\u56fd\u5bb6&quot;\u91cd\u5927\u65b0\u836f\u521b\u5236&quot;\u4e13\u9879\u3002\u516c\u53f8\u5df2\u6709 7\u4e2a\u4ea7\u54c1\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aTYVYT<sup>&reg;<\/sup>\uff1b\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u6538\u540c<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aBYVASDA <sup>&reg;<\/sup>\uff1b\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u82cf\u7acb\u4fe1<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aSULINNO <sup>&reg;<\/sup>\uff1b\u5229\u59a5\u6614\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u534e<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aHALPRYZA<sup>&reg;<\/sup>; \u4f69\u7c73\u66ff\u5c3c\u7247\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u5766<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aPEMAZYRE<sup>&reg;<\/sup>; \u5965\u96f7\u5df4\u66ff\u5c3c\uff0c\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b<sup>&reg;<\/sup>; \u96f7\u83ab\u897f\u5c24\u5355\u6297\uff0c\u5546\u54c1\u540d\uff1a\u5e0c\u5189\u62e9<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aCYRAMZA<sup>&reg;<\/sup>\uff09\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c 2\u4e2a\u54c1\u79cd\u5728NMPA\u5ba1\u8bc4\u4e2d\uff0c4\u4e2a\u54c1\u79cd\u8fdb\u5165III\u671f\u6216\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u8fd8\u670919\u4e2a\u4ea7\u54c1\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u4fe1\u8fbe\u751f\u7269\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u5177\u6709\u56fd\u9645\u5148\u8fdb\u6c34\u5e73\u7684\u9ad8\u7aef\u751f\u7269\u836f\u5f00\u53d1\u3001\u4ea7\u4e1a\u5316\u4eba\u624d\u56e2\u961f\uff0c\u5305\u62ec\u4f17\u591a\u6d77\u5f52\u4e13\u5bb6\uff0c\u5e76\u4e0e\u7f8e\u56fd\u793c\u6765\u5236\u836f\u3001Adimab\u3001Incyte\u3001MD Anderson \u764c\u75c7\u4e2d\u5fc3\u548c\u97e9\u56fdHanmi\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002<\/p>\n<p>\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1a<a href=\"http:\/\/www.innoventbio.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.innoventbio.com<\/a>\u6216\u516c\u53f8\u9886\u82f1\u8d26\u53f7\uff1aInnovent Biologics\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528&quot;\u9884\u671f&quot;\u3001&quot;\u76f8\u4fe1&quot;\u3001&quot;\u9884\u6d4b&quot;\u3001&quot;\u671f\u671b&quot;\u3001&quot;\u6253\u7b97&quot;\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u5747\u5c5e\u4e8e\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u5e76\u65e0\u4e49\u52a1\u4e0d\u65ad\u5730\u66f4\u65b0\u8fd9\u4e9b\u9884\u6d4b\u6027\u9648\u8ff0\u3002<\/p>\n<p>\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u662f\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u662f\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n<p>\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u96c7\u5458\u4ee3\u7406\u6982\u4e0d\u627f\u62c5&nbsp;(a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7f51\u7ad9\u6240\u8f7d\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u4e49\u52a1;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5b9e\u73b0\u6216\u53d8\u6210\u4e0d\u6b63\u786e\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8d23\u4efb\u3002<\/p>\n<p>\u58f0\u660e\uff1a<\/p>\n<p><i>1. \u8be5\u9002\u5e94\u75c7\u4e3a\u7814\u7a76\u4e2d\u7684\u836f\u54c1\u7528\u6cd5\uff0c\u5c1a\u672a\u5728\u4e2d\u56fd\u83b7\u6279\uff1b<br \/><\/i><i>2. \u4fe1\u8fbe\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u83b7\u6279\u7684\u836f\u54c1\/\u9002\u5e94\u75c7\u4f7f\u7528\u3002<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u56fd\u65e7\u91d1\u5c71\u548c\u4e2d\u56fd\u82cf\u5dde2022\u5e746\u670813\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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2022\uff09\u63a5\u53d7\u5e76\u4ee5\u7ebf\u4e0a\u58c1\u62a5\uff08ODP014\uff09\u5f62\u5f0f\u53d1\u8868\u3002 \u8be5\u7814\u7a76\uff08ClinicalTrials.gov, NCT04440345\uff09\u662f\u4e00\u9879\u5728\u4e2d\u56fd\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u8bc4\u4f30mazdutide\u591a\u6b21\u5242\u91cf\u9012\u589e\u7ed9\u836f\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u836f\u4ee3\/\u836f\u6548\u52a8\u529b\u5b66\u7279\u5f81\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\u3002\u7814\u7a76\u52065\u4e2a\u961f\u5217\uff0c\u6bcf\u4e2a\u961f\u5217\u4e2d12\u4f8b\u53d7\u8bd5\u8005\u63092\uff1a1\u7684\u6bd4\u4f8b\u968f\u673a\u63a5\u53d71.0-2.0-3.0 mg \uff08\u961f\u52171\uff09\uff0c1.5-3.0-4.5 mg\uff08\u961f\u52172\uff09\u30012.0-4.0-6.0 mg\uff08\u961f\u52173\uff09\u30012.5-5.0-7.5-10.0 mg\uff08\u961f\u52174\uff09\u62163.0-6.0-9.0 mg\uff08\u961f\u52175\uff09 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[1]Ji L, Jiang H, An P, et al. 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