{"id":69251,"date":"2022-05-24T18:00:00","date_gmt":"2022-05-24T11:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022052418000069251"},"modified":"2022-05-25T06:46:04","modified_gmt":"2022-05-24T22:46:04","slug":"%e4%ba%91%e9%a1%b6%e6%96%b0%e8%80%80%e6%8e%88%e6%9d%83%e5%90%88%e4%bd%9c%e4%bc%99%e4%bc%b4%e8%be%89%e7%91%9e%e5%85%ac%e5%b8%83elevate%e8%af%95%e9%aa%8c%e7%9a%84%e5%85%b3%e9%94%ae%e6%80%a7%e7%a0%94","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022052418000069251","title":{"rendered":"\u4e91\u9876\u65b0\u8000\u6388\u6743\u5408\u4f5c\u4f19\u4f34\u8f89\u745e\u516c\u5e03ELEVATE\u8bd5\u9a8c\u7684\u5173\u952e\u6027\u7814\u7a76\u7ed3\u679c\uff0c\u663e\u793aEtrasimod\u6709\u671b\u6210\u4e3a\u6cbb\u7597\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684Best-in-Class\u836f\u7269"},"content":{"rendered":"

\u4e0a\u6d77<\/span>2022\u5e745\u670824\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u4e91\u9876\u65b0\u8000\uff08HKEX 1952.HK\uff09\u7684\u6388\u6743\u5408\u4f5c\u4f19\u4f34\u8f89\u745e\u516c\u53f8\uff08\u7ebd\u7ea6\u8bc1\u5238\u4ea4\u6613\u6240\u80a1\u7968\u4ee3\u7801\uff1aPFE\uff09\u57282022\u5e74\u7f8e\u56fd\u6d88\u5316\u75be\u75c5\u5468\uff08DDW\uff09\u4e0a\u516c\u5e03\u4e86ELEVATE UC 3\u671f\u6ce8\u518c\u8bd5\u9a8c\u4e2d\u4e24\u9879\u5173\u952e\u6027\u7814\u7a76\u7684\u8be6\u7ec6\u7ed3\u679c\uff0c\u7814\u7a76\u8bc4\u4f30\u4e86\u9009\u62e9\u6027\u9798\u6c28\u9187-1-\u78f7\u9178\uff08S1P\uff09\u53d7\u4f53\u8c03\u8282\u5242etrasimod\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u6cbb\u7597\u4e2d\u91cd\u5ea6\u6d3b\u52a8\u6027\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\uff08UC\uff09\u7684\u6548\u679c\u3002<\/p>\n

\u8fd9\u4e24\u98793\u671f\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76\u90fd\u8fbe\u5230\u4e86\u6240\u6709\u4e3b\u8981\u7ec8\u70b9\u548c\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff0c\u4e14etrasimod\u663e\u793a\u51fa\u4e0e\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\u7684\u5b89\u5168\u6027\u3002\u5728\u4e3a\u671f52\u5468\u7684ELEVATE UC 52\u7814\u7a76\u4e2d\uff0c\u7b2c12\u5468\u65f6\uff0c\u63a5\u53d7etrasimod\u6cbb\u7597\u7684\u60a3\u8005\u4e34\u5e8a\u7f13\u89e3\u7387\u4e3a27.0%\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5242\u5bf9\u7167\u7684\u60a3\u8005\u4e3a7.4%\uff08\u76f8\u5dee19.8%\uff0cP=\u02c2.001\uff09\uff1b\u7b2c52\u5468\u65f6\uff0c\u63a5\u53d7etrasimod\u6cbb\u7597\u7684\u60a3\u8005\u4e34\u5e8a\u7f13\u89e3\u7387\u4e3a32.1%\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5242\u5bf9\u7167\u7684\u60a3\u8005\u4e3a6.7%\uff08\u76f8\u5dee25.4%\uff0cP=\u02c2.001\uff09\u3002\u5728\u4e3a\u671f12\u5468\u7684ELEVATE UC 12\u7814\u7a76\u4e2d\uff0c\u63a5\u53d7etrasimod\u6cbb\u7597\u7684\u60a3\u8005\u4e34\u5e8a\u7f13\u89e3\u7387\u4e3a24.8%\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5242\u6cbb\u7597\u7684\u60a3\u8005\u4e3a15.2%\uff08\u76f8\u5dee9.7%\uff0cP=.0264\uff09\u3002<\/p>\n

\u4e3a\u671f52\u5468\u7684ELEVATE UC 52\u7814\u7a76\u91c7\u7528\u4e86\u9ad8\u5ea6\u6a21\u62df\u771f\u5b9e\u4e16\u754c\u7684\u6301\u7eed\u6cbb\u7597\u7684\u4e34\u5e8a\u8bbe\u8ba1\u3002ELEVATE UC 52\u7684\u6240\u6709\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u90fd\u53d6\u5f97\u4e86\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u6539\u5584\uff0c\u5305\u62ec\u5728\u7b2c12\u5468\u548c\u7b2c52\u5468\u65f6\u7684\u5185\u7aa5\u955c\u6539\u5584\u3001\u75c7\u72b6\u7f13\u89e3\u548c\u7c98\u819c\u6108\u5408\uff0c\u4ee5\u53ca\u7b2c52\u5468\u65f6\u7684\u65e0\u76ae\u8d28\u7c7b\u56fa\u9187\u7f13\u89e3\u548c\u6301\u7eed\u4e34\u5e8a\u7f13\u89e3\u3002ELEVATE UC 12\u7814\u7a76\u5728\u7b2c12\u5468\u65f6\u4e5f\u8fbe\u5230\u4e86\u6240\u6709\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff0c\u5305\u62ec\u5185\u7aa5\u955c\u6539\u5584\u3001\u75c7\u72b6\u7f13\u89e3\u548c\u7c98\u819c\u6108\u5408\u3002<\/p>\n

\u5728\u8fd9\u4e24\u9879\u7814\u7a76\u7684\u6cbb\u7597\u7ec4\u4e2d\uff0c\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff0c\u5305\u62ec\u4e25\u91cdAE\uff09\u7c7b\u4f3c\u3002\u622a\u81f3\u7b2c52\u5468\uff0cetrasimod\u6cbb\u7597\u7ec4\u4e2d\u53d1\u751f\u7387\u4e3a3%\u53ca\u4ee5\u4e0a\u4e14\u9ad8\u4e8e\u5b89\u6170\u5242\u6cbb\u7597\u7ec4\u7684\u6700\u5e38\u89c1\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u5934\u75db\u3001UC\u52a0\u91cd\u3001COVID-19\u611f\u67d3\u3001\u5934\u6655\u3001\u53d1\u70ed\u3001\u5173\u8282\u75db\u3001\u8179\u75db\u548c\u6076\u5fc3\u3002\u6ca1\u6709\u62a5\u544a\u5fc3\u52a8\u8fc7\u7f13\u6216\u623f\u5ba4\u963b\u6ede\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002<\/p>\n

Etrasimod\u7531Arena Pharmaceuticals\u516c\u53f8\u5f00\u53d1\uff0c\u8f89\u745e\u4e8e\u8fd1\u671f\u5b8c\u6210\u4e86\u5bf9Arena Pharmaceuticals\u7684\u6536\u8d2d\uff0c\u800c\u4e91\u9876\u65b0\u8000\u4e8e2017\u5e74\u4eceArena\u83b7\u5f97\u4e86\u5728\u5927\u4e2d\u534e\u533a\u548c\u97e9\u56fd\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316etrasimod\u7684\u72ec\u5bb6\u6743\u5229\u3002\u4e91\u9876\u65b0\u8000\u6b63\u5728\u4e9a\u6d32\u8fdb\u884cetrasimod\u6cbb\u7597\u4e2d\u91cd\u5ea6\u6d3b\u52a8\u6027\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u76843\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u9884\u8ba1\u5c06\u4e8e2023\u5e74\u5b8c\u6210\u5165\u7ec4\u3002<\/p>\n

\u4e91\u9876\u65b0\u8000\u9996\u5e2d\u6267\u884c\u5b98\u8584\u79d1\u745e\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u7684\u5408\u4f5c\u4f19\u4f34\u5f00\u5c55\u7684ELEVATE UC 3\u671f\u9879\u76ee\u7684\u8be6\u7ec6\u7ed3\u679c\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86etrasimod\u6709\u671b\u6210\u4e3abest-in-class\u7597\u6cd5\uff0c\u8fd9\u589e\u5f3a\u4e86\u6211\u4eec\u5bf9\u5728\u4e9a\u6d32\u5f00\u5c55\u7684\u4e34\u5e8a\u7814\u7a76\u7684\u4fe1\u5fc3\uff0c\u6211\u4eec\u5e0c\u671b\u4e9a\u6d32\u7684\u8bd5\u9a8c\u4e5f\u80fd\u53d6\u5f97\u7c7b\u4f3c\u7684\u79ef\u6781\u7ed3\u679c\u3002\u201d<\/p>\n

ELEVATE UC 52\u548cUC 12\u7684\u6570\u636e\u9884\u671f\u5c06\u7528\u4e8e\u76d1\u7ba1\u7533\u8bf7\uff0c\u8f89\u745e\u9884\u8ba1\u5c06\u4e8e\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u5f00\u59cb\u8fdb\u884c\u76d1\u7ba1\u7533\u62a5\u3002\u6709\u5173\u8fd9\u4e9b\u7814\u7a76\u7684\u66f4\u591a\u4fe1\u606f\u53ef\u8bbf\u95eewww.clinicaltrials.gov<\/a>\uff0c\u6ce8\u518c\u7f16\u53f7\u4e3aNCT03945188\u3001NCT03996369\u548cNCT03950232\u3002<\/p>\n

\u5173\u4e8e<\/b>Etrasimod<\/b><\/p>\n

Etrasimod \u662f\u4e00\u79cd\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7684\u9009\u62e9\u6027\u9798\u6c28\u9187-1-\u78f7\u9178\uff08S1P\uff09\u53d7\u4f53\u8c03\u8282\u5242\uff0c\u4e0eS1P\u53d7\u4f531\u30014\u548c5\u7ed3\u5408\uff0c\u6b63\u5728\u7814\u7a76\u5c06\u5176\u7528\u4e8e\u6cbb\u7597\u4e00\u7cfb\u5217\u514d\u75ab\u708e\u75c7\u6027\u75be\u75c5\uff0c\u5305\u62ec\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u3001\u514b\u7f57\u6069\u6c0f\u75c5\u3001\u7279\u5e94\u6027\u76ae\u708e\u3001\u55dc\u9178\u7ec6\u80de\u6027\u98df\u7ba1\u708e\u548c\u6591\u79c3\u3002<\/p>\n

\u5173\u4e8e<\/b>ELEVATE UC 52<\/b>\u548c<\/b>ELEVATE UC 12<\/b><\/p>\n

ELEVATE UC 52\u548cELEVATE UC 12\u662fELEVATE UC 3\u671f\u6ce8\u518c\u9879\u76ee\u4e2d\u7684\u5173\u952e\u6027\u8bd5\u9a8c\u3002<\/p>\n

ELEVATE UC 52\u662f\u4e00\u9879\u91c7\u7528\u6301\u7eed\u6cbb\u7597\u8bbe\u8ba1\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg etrasimod\u572812\u5468\u548c52\u5468\u6cbb\u7597\u540e\u7684\u5b89\u5168\u6027\u548c\u8fbe\u5230\u4e34\u5e8a\u7f13\u89e3\u7684\u7597\u6548\u3002\u5728\u8fd9\u9879\u4e3a\u671f52\u5468\u7684\u7814\u7a76\u4e2d\uff0c\u4ece\u4efb\u4e00\u6cbb\u7597\u7ec4\u4e2d\u9000\u51fa\u7684\u6240\u6709\u60a3\u8005\u90fd\u6309\u65e0\u5e94\u7b54\u8005\u8ba1\u3002\u4e3b\u8981\u7ec8\u70b9\u57fa\u4e8e 3 \u4e2a\u5b50\u9879\u7684\u6539\u826f\u6885\u5965\u8bc4\u5206\uff08MMS\uff09\u3002\u5173\u952e\u6b21\u8981\u6307\u6807\u5305\u62ec\u7b2c12\u5468\u548c\u7b2c 52 \u5468\u65f6\u7684\u5185\u7aa5\u955c\u6539\u5584\u3001\u75c7\u72b6\u7f13\u89e3\u548c\u7c98\u819c\u6108\u5408\u60c5\u51b5\u4ee5\u53ca\u7b2c52\u5468\u65f6\u7684\u65e0\u76ae\u8d28\u7c7b\u56fa\u9187\u7f13\u89e3\u548c\u6301\u7eed\u4e34\u5e8a\u7f13\u89e3\u3002<\/p>\n

ELEVATE UC 12\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u4e2d\u91cd\u5ea6\u6d3b\u52a8\u6027\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u60a3\u8005\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg etrasimod\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u8be5\u8bd5\u9a8c\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8bc4\u4f30etrasimod\u572812\u5468\u6cbb\u7597\u540e\u7684\u5b89\u5168\u6027\u548c\u8fbe\u5230\u4e34\u5e8a\u7f13\u89e3\u7684\u7597\u6548\uff0c\u8bc4\u4f30\u57fa\u4e8eFDA\u8981\u6c42\u76843\u4e2a\u5b50\u9879\u7684\u6539\u826f\u6885\u5965\u8bc4\u5206\u3002\u5173\u952e\u6b21\u8981\u6307\u6807\u5305\u62ec\u5185\u7aa5\u955c\u6539\u5584\u3001\u75c7\u72b6\u7f13\u89e3\u548c\u7c98\u819c\u6108\u5408\u60c5\u51b5\u3002<\/p>\n

\u8fd9\u4e24\u9879\u8bd5\u9a8c\u4e2d62.6%\u63a5\u53d7etrasimod\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u4ee5\u53caELEVATE UC 52\u4e2d61.8%\u548cELEVATE UC 12\u4e2d62.9%\u63a5\u53d7\u5b89\u6170\u5242\u6cbb\u7597\u7684\u60a3\u8005\u4e4b\u524d\u4ece\u672a\u63a5\u53d7\u8fc7\u751f\u7269\u5236\u5242\u6216JAK\u6291\u5236\u5242\u6cbb\u7597\u3002<\/p>\n

\u5173\u4e8e\u6e83\u75a1\u6027\u7ed3\u80a0\u708e<\/b><\/p>\n

\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u662f\u4e00\u79cd\u6162\u6027\u3001\u901a\u5e38\u4f7f\u4eba\u8870\u5f31\u7684\u708e\u75c7\u6027\u80a0\u75c5[i]<\/sup>\uff0c\u5168\u7403\u60a3\u75c5\u7387\u8f83\u9ad8\uff0c\u5317\u7f8e\u548c\u6b27\u6d32\u4f30\u8ba1\u6709 380 \u4e07\u4eba\u60a3\u6709\u6b64\u75c5[ii]<\/sup>\uff0c\u4e2d\u56fd\u548c\u4e9a\u592a\u5730\u533a\u7684\u53d1\u75c5\u7387\u6b63\u5448\u9010\u5e74\u4e0a\u5347\u7684\u8d8b\u52bf\uff0c\u4e2d\u56fd\u7684\u53d1\u75c5\u7387\u5df2\u8d85\u8fc711.6\/10\u4e07\u4eba\u3002\u8be5\u75c5\u75c7\u72b6\u53ef\u80fd\u5305\u62ec\u6162\u6027\u8179\u6cfb\u4f34\u8840\u6db2\u548c\u9ecf\u6db2\u3001\u8179\u75db\u548c\u91cc\u6025\u540e\u91cd[iii],<\/sup>\uff0c\u5176\u53ef\u5bf9\u60a3\u8005\u5de5\u4f5c\u3001\u5bb6\u5ead\u548c\u793e\u4f1a\u6d3b\u52a8\u4ea7\u751f\u663e\u8457\u5f71\u54cd[iv]<\/sup>\u3002<\/span><\/p>\n

\u5173\u4e8e\u4e91\u9876\u65b0\u8000<\/b><\/p>\n

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\n\n\n\n\n\n\n
\n

[i] Crohn’s and Colitis Foundation. What is Ulcerative Colitis. \u53c2\u89c1\uff1a What is Ulcerative Colitis? | Crohn’s & Colitis Foundation (crohnscolitisfoundation.org). <\/a> 2022\u5e744\u670826\u65e5\u8bbf\u95ee\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[ii] Seyedian, SS.  A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease.  J Med Life.<\/i> 2019;12(2):113-122.\u53c2\u89c1\uff1aA review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease – PMC (<\/a>nih.gov<\/a>)\u30022022\u5e744\u670826\u65e5\u8bbf\u95ee\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[iii] Hanauer SB.Inflammatory bowel disease.N Engl J Med.<\/i>1996;334(13):841-8.\u53c2\u89c1\uff1aInflammatory Bowel Disease | NEJM<\/a>\u30022022\u5e744\u670826\u65e5\u8bbf\u95ee\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

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[iv] Irvine EJ.Quality of Life of Patients with Ulcerative Colitis: Past, Present, and Future.Inflammatory Bowel Diseases.2008;14(4):554-563.\u53c2\u89c1\uff1aQuality of life of patients with ulcerative colitis:<\/a>Past, present, and future | Inflammatory Bowel Diseases | Oxford Academic (<\/a>openathens.net<\/a>)\u30022022\u5e744\u670826\u65e5\u8bbf\u95ee\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

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