{"id":69066,"date":"2022-05-05T09:30:00","date_gmt":"2022-05-05T02:30:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022050509300069066"},"modified":"2022-05-05T17:53:55","modified_gmt":"2022-05-05T09:53:55","slug":"%e8%bf%aa%e5%93%b2%e5%8c%bb%e8%8d%af%e9%87%8d%e7%a3%85%e9%a1%b9%e7%9b%ae%e8%88%92%e6%b2%83%e6%9b%bf%e5%b0%bc%e8%8d%a3%e7%99%bb%e3%80%8acancer-discovery%e3%80%8b%ef%bc%8c%e5%bd%b0%e6%98%be%e4%b8%ad","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022050509300069066","title":{"rendered":"\u8fea\u54f2\u533b\u836f\u91cd\u78c5\u9879\u76ee\u8212\u6c83\u66ff\u5c3c\u8363\u767b\u300aCancer Discovery\u300b\uff0c\u5f70\u663e\u4e2d\u56fd\u79d1\u521b\u786c\u6838\u5b9e\u529b"},"content":{"rendered":"

\u4e0a\u6d77<\/span>2022\u5e745\u67085\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u8fd1\u65e5\uff0c\u8fea\u54f2\u533b\u836f<\/span>\u81ea\u4e3b\u7814\u53d1\u7684\u5168\u7403\u9996\u521b\u5c0f\u5206\u5b50\u5316\u5408\u7269\u8212\u6c83\u66ff\u5c3c\uff08DZD9008\uff09\u7684\u836f\u7269\u7814\u53d1\u3001\u8f6c\u5316\u79d1\u5b66\u548c\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u53d1\u8868\u5728\u56fd\u9645\u9876\u7ea7\u671f\u520a\u300aCancer Discovery\u300b[1]\uff08\u300a\u764c\u75c7\u53d1\u73b0\u300b\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a39.397\uff09\u3002\u8212\u6c83\u66ff\u5c3c\u662f\u8fea\u54f2\u9488\u5bf9EGFR\u7a81\u53d8\u5bfc\u81f4\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u800c\u8bbe\u8ba1\u7684\u65b0\u4e00\u4ee3\u9776\u5411\u836f\u7269\u3002\u5317\u4eac\u534f\u548c\u533b\u9662\u547c\u5438\u4e0e\u5371\u91cd\u75c7\u533b\u5b66\u79d1\u738b\u5b5f\u662d\u6559\u6388\u548c\u53f0\u6e7e\u5927\u5b66\u533b\u5b66\u9662\u9644\u8bbe\u533b\u9662\u764c\u533b\u4e2d\u5fc3\u5206\u9662\u6768\u5fd7\u65b0\uff08James Chih-Hsin Yang\uff09\u6559\u6388\u4e3a\u6587\u7ae0\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u7f8e\u56fd\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09Pasi A. Jänne\u6559\u6388\u4e3a\u672c\u6587\u7684\u901a\u8baf\u4f5c\u8005\u3002<\/p>\n

\u300aCancer Discovery\u300b\u662f\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u51fa\u7248\u96c6\u56e2\u7684\u6838\u5fc3\u520a\u7269\uff0c\u53d1\u8868\u5177\u6709\u9ad8\u5f71\u54cd\u529b\u3001\u7ecf\u540c\u884c\u8bc4\u5ba1\u3001\u652f\u6301\u4e34\u5e8a\u8bd5\u9a8c\u7684\u57fa\u7840\u7814\u7a76\u548c\u8f6c\u5316\u79d1\u5b66\u9886\u57df\u7684\u5168\u7403\u91cd\u5927\u6210\u679c\u8fdb\u5c55\uff0c\u4e3b\u8981\u53d1\u6587\u673a\u6784\u4e3a\u5168\u7403\u8457\u540d\u9ad8\u6821\u548c\u5c16\u7aef\u80bf\u7624\u7814\u7a76\u673a\u6784\u3002\u672c\u6b21\u516c\u53f8\u5728\u7814\u4ea7\u54c1\u8212\u6c83\u66ff\u5c3c\u7814\u7a76\u6210\u679c\u88ab\u80bf\u7624\u9886\u57dfSCI\u5f71\u54cd\u56e0\u5b50\u5168\u7403\u524d\u5341\u5927\u56fd\u9645\u9876\u5c16\u671f\u520a\u6536\u5f55\uff0c\u7a81\u663e\u4e86\u8fea\u54f2\u533b\u836f\u5728\u836f\u7269\u7814\u53d1\u3001\u8f6c\u5316\u79d1\u5b66\u548c\u4e34\u5e8a\u7814\u7a76\u4e0a\u7684\u5168\u7403\u7ade\u4e89\u529b\u3002<\/p>\n

"\u8212\u6c83\u66ff\u5c3c\u662f\u8fc4\u4eca\u4e3a\u6b62\u80ba\u764c\u9886\u57df\u9996\u4e2a\u4e14\u552f\u4e00\u83b7\u5f97\u4e2d\u3001\u7f8e\u53cc\u91cd\u2018\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff08BTD\uff09\u7684\u4e2d\u56fd\u539f\u7814\u521b\u65b0\u836f\uff0c"\u8d1f\u8d23\u7275\u5934\u56fd\u5185\u591a\u4e2d\u5fc3\u5173\u952e\u6027\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u7684\u738b\u5b5f\u662d\u6559\u6388\u8868\u793a\uff0c"\u8212\u6c83\u66ff\u5c3c\u7814\u7a76\u6210\u679c\u83b7\u5f97\u56fd\u5185\u5916\u9ad8\u5ea6\u5173\u6ce8\uff0c\u5c06\u4e3a\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u643a\u5e26EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\uff08EGFR Exon20ins mutations\uff09\u7684\u60a3\u8005\u5e26\u6765\u66d9\u5149\u3002"<\/p>\n

\u6768\u5fd7\u65b0\u6559\u6388\u8868\u793a\uff1a"\u8212\u6c83\u66ff\u5c3c\u76f8\u6bd4\u540c\u7c7b\u4ea7\u54c1\uff0c\u5177\u6709\u66f4\u597d\u7684\u5b89\u5168\u6027\u548c\u4f9d\u4ece\u6027\u3002\u8212\u6c83\u66ff\u5c3c\u7684\u4e0d\u826f\u53cd\u5e94\u8c31\u4e0e\u5df2\u83b7\u6279\u7684EGFR TKI\u7c7b\u4f3c\uff0c\u65e0\u7279\u6b8a\u4e0d\u826f\u53cd\u5e94\uff0c\u56e0\u836f\u7269\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u5bfc\u81f4\u6c38\u4e45\u505c\u836f\u3001\u51cf\u5242\u91cf\u53ca\u22653\u7ea7TEAEs\uff08\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff09\u53d1\u751f\u7387\u8f83\u4f4e\u3002"<\/p>\n

Pasi A. Jänne\u6559\u6388\u662f\u8212\u6c83\u66ff\u5c3c\u5728\u4e2d\u56fd\u4ee5\u5916\u5f00\u5c55\u56fd\u9645\u591a\u4e2d\u5fc3\u5173\u952e\u6027\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u4ed6\u8868\u793a\uff0c"\u8212\u6c83\u66ff\u5c3c\u5177\u5907\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c100 mg \u53ca\u4ee5\u4e0a\u5242\u91cf\u5728\u4e0d\u540c\u4e9a\u578b\u7684 EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u6297\u80bf\u7624\u7597\u6548\uff0c\u5e76\u5728\u8111\u8f6c\u79fb\u60a3\u8005\u53caAmivantamab\u7597\u6548\u4e0d\u4f73\u6216\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u60a3\u8005\u4e2d\u5747\u663e\u793a\u7597\u6548\uff0c\u6700\u4f73\u80bf\u7624\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe\u523048.4%\u3002"<\/p>\n

"\u8212\u6c83\u66ff\u5c3c\u539f\u521b\u7814\u7a76\u6210\u679c\u5728\u56fd\u9645\u6700\u9ad8\u7ea7\u5b66\u672f\u671f\u520aCancer Discovery\u4e0a\u53d1\u8868\u518d\u6b21\u5f70\u663e\u4e86\u8fea\u54f2\u7684\u65b0\u836f\u6e90\u5934\u521b\u65b0\u80fd\u529b\u3002\u8212\u6c83\u66ff\u5c3c\u4e34\u5e8a\u524d\u624e\u5b9e\u7684\u7814\u7a76\u548c\u4f18\u5f02\u7684\u8f6c\u5316\u79d1\u5b66\u6570\u636e\u662f\u6211\u4eec\u80fd\u591f\u5438\u5f15\u56fd\u5185\u5916\u9876\u7ea7\u80ba\u764c\u4e34\u5e8a\u4e13\u5bb6\u5408\u4f5c\u7684\u57fa\u7840\u3002\u548c\u7ade\u54c1\u76f8\u6bd4\uff0c\u8212\u6c83\u66ff\u5c3c\u5728\u4e34\u5e8a\u4e0a\u8868\u73b0\u51fa\u6765\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u4f18\u52bf\u518d\u6b21\u5f97\u5230\u5370\u8bc1\uff0c\u4e5f\u83b7\u5f97\u4e86\u4e2d\u7f8e\u4e24\u56fd\u836f\u7269\u76d1\u7ba1\u90e8\u95e8\u7684\u8ba4\u53ef\uff0c\u7ed9\u4e88\u4e86\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u3002"\u8fea\u54f2\u8463\u4e8b\u957f\u3001\u9996\u5e2d\u6267\u884c\u5b98\u5f20\u5c0f\u6797\u535a\u58eb\u8868\u793a\uff0c"\u516c\u53f8\u7684\u53d1\u5c55\u6218\u7565\u5c31\u662f\u7784\u51c6\u6076\u6027\u80bf\u7624\u3001\u514d\u75ab\u6027\u75be\u75c5\u9886\u57df\uff0c\u5229\u7528\u8f6c\u5316\u79d1\u5b66\u548c\u5206\u5b50\u8bbe\u8ba1\u7684\u4f18\u52bf\uff0c\u643a\u624b\u5168\u7403\u9876\u7ea7\u533b\u7597\u7814\u7a76\u673a\u6784\u505a\u5168\u7403\u6700\u597d\u7684\u521b\u65b0\u836f\u3002"<\/p>\n

\u516c\u53f8\u7814\u53d1\u7ba1\u7406\u56e2\u961f\u7cfb\u539f\u963f\u65af\u5229\u5eb7\u5168\u7403\u552f\u4e00\u80bf\u7624\u8f6c\u5316\u79d1\u5b66\u4e2d\u5fc3\u56e2\u961f\uff0c\u66fe\u5bf9\u963f\u65af\u5229\u5eb7\u7684\u591a\u4e2a\u91cd\u78c5\u4ea7\u54c1\u5305\u62ec\u6cf0\u745e\u6c99\u3001\u6613\u745e\u6c99\u505a\u51fa\u91cd\u5927\u8d21\u732e\u3002\u7acb\u8db3\u4e8e\u5bf9EGFR\u9886\u57df\u7684\u6df1\u523b\u7406\u89e3\uff0c\u516c\u53f8\u4eceEGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08EGFR Exon20ins NSCLC\uff09\u8fd9\u4e00\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u51fa\u53d1\uff0c\u901a\u8fc7\u5bf9EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u7684\u86cb\u767d\u7ed3\u6784\u4ee5\u53ca\u5df2\u6709EGFR-TKI\u5316\u5b66\u7ed3\u6784\u7684\u5206\u6790\uff0c\u7ecf\u8fc7\u591a\u8f6e\u8bbe\u8ba1\u3001\u5408\u6210\u3001\u6d4b\u8bd5\uff0c\u7814\u53d1\u51fa\u8212\u6c83\u66ff\u5c3c\u8fd9\u4e00\u9ad8\u6548\u3001\u9ad8\u9009\u62e9\u6027\u53ca\u5177\u6709\u826f\u597d\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u7684\u5168\u65b0\u4e00\u4ee3EGFR-TKI\uff0c\u80fd\u591f\u6709\u6548\u6291\u5236EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\uff0c\u5e76\u5bf9EGFR\u654f\u611f\u7a81\u53d8\u3001T790M\u53cc\u7a81\u53d8\u548c\u7f55\u89c1\u7a81\u53d8\u5747\u6709\u6548\uff0c\u540c\u65f6\u4fdd\u6301\u5bf9\u91ce\u751f\u578bEGFR\u7684\u9ad8\u9009\u62e9\u6027\u3002\u8212\u6c83\u66ff\u5c3c\u4e8e2019\u5e747\u6708\u5b8c\u6210\u9996\u4f8b\u53d7\u8bd5\u8005\u7ed9\u836f\uff0c\u73b0\u5904\u4e8e\u5168\u7403\u5173\u952e\u6027\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002<\/p>\n

\u4e00\u3001\u5173\u4e8e<\/b>EGFR Exon20ins NSCLC<\/b><\/p>\n

\u5728\u5168\u7403\u6076\u6027\u80bf\u7624\u5bfc\u81f4\u7684\u6b7b\u4ea1\u4e2d\uff0c\u80ba\u764c\u6392\u540d\u7b2c\u4e00\u3002\u80ba\u764c\u5206\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u548c\u5c0f\u7ec6\u80de\u80ba\u764c\u4e24\u5927\u7c7b\uff0c\u5176\u4e2d\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7ea6\u5360\u80ba\u764c\u768485%\uff0c\u800cEGFR\u7a81\u53d8\u662fNSCLC\u6700\u5e38\u89c1\u7684\u57fa\u56e0\u7a81\u53d8\u7c7b\u578b\u3002\u56fd\u9645\u4e0a\uff0c\u5409\u975e\u66ff\u5c3c\u3001\u5965\u5e0c\u66ff\u5c3c\u7b49\u7b2c\u4e00\u3001\u4e8c\u548c\u4e09\u4ee3EGFR-TKI\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u643a\u5e26EGFR\u654f\u611f\u7a81\u53d8\u3001T790M\u7a81\u53d8\u548c\u90e8\u5206\u7f55\u89c1\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u4f46EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u7531\u4e8e\u5176\u72ec\u7279\u7684\u86cb\u767d\u7ed3\u6784\uff0c\u7b2c\u4e00\u3001\u4e8c\u548c\u4e09\u4ee3EGFR-TKI\u5bf9\u5176\u6ca1\u6709\u660e\u663e\u6548\u679c\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0cNSCLC\u4e2d\u5df2\u53d1\u73b0\u591a\u79cd\u4e0d\u540c\u7684EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u4e9a\u578b\uff0c\u5404\u4e9a\u578b\u5bf9\u7279\u5b9a\u7684 EGFR TKI \u654f\u611f\u6027\u4e0d\u540c\uff0c\u56e0\u6b64\uff0c\u4e9f\u9700\u5f00\u53d1\u51fa\u80fd\u591f\u9ad8\u6548\u6291\u5236EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u5404\u7a81\u53d8\u4e9a\u578b\u7684EGFR TKI\u3002<\/p>\n

\u4e8c\u3001\u5173\u4e8e\u8212\u6c83\u66ff\u5c3c<\/b><\/p>\n

\u8212\u6c83\u66ff\u5c3c\u9996\u9009\u9002\u5e94\u75c7\u4e3a\u6cbb\u7597EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u6b63\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6b27\u6d32\u3001\u97e9\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u65e5\u672c\u7b49\u56fd\u5bb6\u548c\u5730\u533a\u5f00\u5c55\u5173\u952e\u6027\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u662f\u7ecf\u72ec\u7acb\u5f71\u50cf\u8bc4\u5ba1\u59d4\u5458\u4f1a\u8bc4\u4f30\u7684ORR\u3002\u622a\u81f32021\u5e744\u67083\u65e5\uff0c\u5168\u7403\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u663e\u793a\uff0c\u8212\u6c83\u66ff\u5c3c\u6700\u4f73ORR\u8fbe\u523048.4%\uff0c\u5e76\u5728\u8111\u8f6c\u79fb\u60a3\u8005\u53caAmivantamab\u7597\u6548\u4e0d\u4f73\u6216\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u60a3\u8005\u4e2d\u5747\u663e\u793a\u7597\u6548\u3002\u6b64\u5916\uff0c\u8212\u6c83\u66ff\u5c3c\u5728 EGFR\u654f\u611f\u7a81\u53d8\u3001T790M\u7a81\u53d8\u548c HER2 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u4e5f\u89c2\u5bdf\u5230\u521d\u6b65\u7597\u6548\u3002<\/p>\n

\u8212\u6c83\u66ff\u5c3c\u5177\u5907\u826f\u597d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u3002\u4eba\u4f53\u534a\u8870\u671f\u957f\u8fbe\u7ea650\u5c0f\u65f6\uff0cPK\u66f2\u7ebf\u5e73\u7f13\uff0c\u56e0\u6b64\u8fde\u7eed\u7528\u836f\u8fbe\u5230\u7a33\u6001\u65f6\u836f\u7269\u5cf0\u503c\u6d53\u5ea6\u548c\u8c37\u5e95\u6d53\u5ea6\u5dee\u8ddd\u5c0f\u3002\u4e0a\u8ff0PK\u7279\u5f81\u6709\u5229\u4e8e\u5bf9\u9776\u70b9\u7684\u6301\u7eed\u6291\u5236\uff0c\u4e14\u964d\u4f4e\u7531\u4e8e\u836f\u7269\u5cf0\u503c\u6d53\u5ea6\u8fc7\u9ad8\u5e26\u6765\u7684\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7684\u53ef\u80fd\u6027\u3002\u6b64\u5916\uff0c\u8212\u6c83\u66ff\u5c3c\u4e0e\u5df2\u83b7\u6279EGFR TKI\u76f8\u6bd4\u5177\u5907\u66f4\u597d\u7684\u5b89\u5168\u6027\uff0c\u56e0\u4e3a\u836f\u7269\u76f8\u5173\u7684TEAE\u5bfc\u81f4\u6c38\u4e45\u505c\u836f\u548c\u51cf\u5242\u91cf\u3001\u2265<\/span>3\u7ea7\u836f\u7269\u76f8\u5173TEAEs\u53d1\u751f\u7387\u8f83\u4f4e\u3002<\/p>\n

\u51ed\u501f\u5176\u4f18\u5f02\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u8212\u6c83\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5df2\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3 "\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u54c1\u79cd"\u8ba4\u5b9a\u8d44\u683c\u548c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40 "\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff08Breakthrough Therapy Designation\uff09"\uff0c\u7814\u7a76\u6210\u679c\u5728\u591a\u4e2a\u56fd\u9645\u5b66\u672f\u4f1a\u8bae\uff082019AACR\u30012021ASCO\u30012021WCLC\uff09\u4e0a\u53d1\u8868\u3002<\/p>\n

\u4e09\u3001\u5173\u4e8e\u8fea\u54f2\u533b\u836f<\/b><\/p>\n

\u8fea\u54f2\u533b\u836f\u662f\u4e00\u5bb6\u4ea7\u54c1\u5904\u4e8e\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u7684\u5168\u7403\u521b\u65b0\u578b\u751f\u7269\u533b\u836f\u4f01\u4e1a\uff0c\u4e13\u6ce8\u4e8e\u6076\u6027\u80bf\u7624\u3001\u514d\u75ab\u6027\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7684\u7814\u7a76\u3001\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u3002\u516c\u53f8\u575a\u6301\u6e90\u5934\u521b\u65b0\u7684\u7814\u53d1\u7406\u5ff5\uff0c\u81f4\u529b\u4e8e\u65b0\u9776\u70b9\u7684\u6316\u6398\u4e0e\u4f5c\u7528\u673a\u7406\u9a8c\u8bc1\uff0c\u4ee5\u63a8\u51fa\u5168\u7403\u9996\u521b\u836f\u7269\uff08First-in-class\uff09\u548c\u5177\u6709\u7a81\u7834\u6027\u6f5c\u529b\u7684\u6cbb\u7597\u65b9\u6cd5\u4e3a\u76ee\u6807\uff0c\u529b\u6c42\u586b\u8865\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\uff0c\u5f15\u9886\u884c\u4e1a\u53d1\u5c55\u65b9\u5411\u3002\u76ee\u524d\uff0c\u4e24\u6b3e\u5728\u7814\u836f\u7269\u5904\u4e8e\u5168\u7403\u5173\u952e\u6027\u6ce8\u518c\u4e34\u5e8a\u9636\u6bb5\uff0c\u4e94\u6b3e\u836f\u7269\u5904\u4e8e\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u9636\u6bb5\u3002<\/p>\n

\u56db\u3001\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n

\u672c\u65b0\u95fb\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528"\u9884\u671f"\u3001"\u76f8\u4fe1"\u3001"\u9884\u6d4b"\u3001"\u671f\u671b"\u3001"\u6253\u7b97"\u3001"\u6709\u671b"\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002<\/p>\n

\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n[1] https:\/\/doi.org\/10.1158\/2159-8290.CD-21-1615<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u6d772022\u5e745\u67085\u65e5 \/\u7f8e\u901a\u793e\/ — \u8fd1\u65e5\uff0c\u8fea\u54f2\u533b\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u5168\u7403\u9996\u521b\u5c0f\u5206\u5b50\u5316\u5408\u7269\u8212\u6c83\u66ff\u5c3c\uff08DZD9008\uff09\u7684\u836f\u7269\u7814\u53d1\u3001\u8f6c\u5316\u79d1\u5b66\u548c\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u53d1\u8868\u5728\u56fd\u9645\u9876\u7ea7\u671f\u520a\u300aCancer Discovery\u300b[1]\uff08\u300a\u764c\u75c7\u53d1\u73b0\u300b\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a39.397\uff09\u3002\u8212\u6c83\u66ff\u5c3c\u662f\u8fea\u54f2\u9488\u5bf9EGFR\u7a81\u53d8\u5bfc\u81f4\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u800c\u8bbe\u8ba1\u7684\u65b0\u4e00\u4ee3\u9776\u5411\u836f\u7269\u3002\u5317\u4eac\u534f\u548c\u533b\u9662\u547c\u5438\u4e0e\u5371\u91cd\u75c7\u533b\u5b66\u79d1\u738b\u5b5f\u662d\u6559\u6388\u548c\u53f0\u6e7e\u5927\u5b66\u533b\u5b66\u9662\u9644\u8bbe\u533b\u9662\u764c\u533b\u4e2d\u5fc3\u5206\u9662\u6768\u5fd7\u65b0\uff08James Chih-Hsin Yang\uff09\u6559\u6388\u4e3a\u6587\u7ae0\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u7f8e\u56fd\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09Pasi A. Jänne\u6559\u6388\u4e3a\u672c\u6587\u7684\u901a\u8baf\u4f5c\u8005\u3002 \u300aCancer Discovery\u300b\u662f\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u51fa\u7248\u96c6\u56e2\u7684\u6838\u5fc3\u520a\u7269\uff0c\u53d1\u8868\u5177\u6709\u9ad8\u5f71\u54cd\u529b\u3001\u7ecf\u540c\u884c\u8bc4\u5ba1\u3001\u652f\u6301\u4e34\u5e8a\u8bd5\u9a8c\u7684\u57fa\u7840\u7814\u7a76\u548c\u8f6c\u5316\u79d1\u5b66\u9886\u57df\u7684\u5168\u7403\u91cd\u5927\u6210\u679c\u8fdb\u5c55\uff0c\u4e3b\u8981\u53d1\u6587\u673a\u6784\u4e3a\u5168\u7403\u8457\u540d\u9ad8\u6821\u548c\u5c16\u7aef\u80bf\u7624\u7814\u7a76\u673a\u6784\u3002\u672c\u6b21\u516c\u53f8\u5728\u7814\u4ea7\u54c1\u8212\u6c83\u66ff\u5c3c\u7814\u7a76\u6210\u679c\u88ab\u80bf\u7624\u9886\u57dfSCI\u5f71\u54cd\u56e0\u5b50\u5168\u7403\u524d\u5341\u5927\u56fd\u9645\u9876\u5c16\u671f\u520a\u6536\u5f55\uff0c\u7a81\u663e\u4e86\u8fea\u54f2\u533b\u836f\u5728\u836f\u7269\u7814\u53d1\u3001\u8f6c\u5316\u79d1\u5b66\u548c\u4e34\u5e8a\u7814\u7a76\u4e0a\u7684\u5168\u7403\u7ade\u4e89\u529b\u3002 "\u8212\u6c83\u66ff\u5c3c\u662f\u8fc4\u4eca\u4e3a\u6b62\u80ba\u764c\u9886\u57df\u9996\u4e2a\u4e14\u552f\u4e00\u83b7\u5f97\u4e2d\u3001\u7f8e\u53cc\u91cd\u2018\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff08BTD\uff09\u7684\u4e2d\u56fd\u539f\u7814\u521b\u65b0\u836f\uff0c"\u8d1f\u8d23\u7275\u5934\u56fd\u5185\u591a\u4e2d\u5fc3\u5173\u952e\u6027\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u7684\u738b\u5b5f\u662d\u6559\u6388\u8868\u793a\uff0c"\u8212\u6c83\u66ff\u5c3c\u7814\u7a76\u6210\u679c\u83b7\u5f97\u56fd\u5185\u5916\u9ad8\u5ea6\u5173\u6ce8\uff0c\u5c06\u4e3a\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u643a\u5e26EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\uff08EGFR Exon20ins mutations\uff09\u7684\u60a3\u8005\u5e26\u6765\u66d9\u5149\u3002" \u6768\u5fd7\u65b0\u6559\u6388\u8868\u793a\uff1a"\u8212\u6c83\u66ff\u5c3c\u76f8\u6bd4\u540c\u7c7b\u4ea7\u54c1\uff0c\u5177\u6709\u66f4\u597d\u7684\u5b89\u5168\u6027\u548c\u4f9d\u4ece\u6027\u3002\u8212\u6c83\u66ff\u5c3c\u7684\u4e0d\u826f\u53cd\u5e94\u8c31\u4e0e\u5df2\u83b7\u6279\u7684EGFR TKI\u7c7b\u4f3c\uff0c\u65e0\u7279\u6b8a\u4e0d\u826f\u53cd\u5e94\uff0c\u56e0\u836f\u7269\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u5bfc\u81f4\u6c38\u4e45\u505c\u836f\u3001\u51cf\u5242\u91cf\u53ca\u22653\u7ea7TEAEs\uff08\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff09\u53d1\u751f\u7387\u8f83\u4f4e\u3002" Pasi A. Jänne\u6559\u6388\u662f\u8212\u6c83\u66ff\u5c3c\u5728\u4e2d\u56fd\u4ee5\u5916\u5f00\u5c55\u56fd\u9645\u591a\u4e2d\u5fc3\u5173\u952e\u6027\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u4ed6\u8868\u793a\uff0c"\u8212\u6c83\u66ff\u5c3c\u5177\u5907\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c100 mg \u53ca\u4ee5\u4e0a\u5242\u91cf\u5728\u4e0d\u540c\u4e9a\u578b\u7684 EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u6297\u80bf\u7624\u7597\u6548\uff0c\u5e76\u5728\u8111\u8f6c\u79fb\u60a3\u8005\u53caAmivantamab\u7597\u6548\u4e0d\u4f73\u6216\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u60a3\u8005\u4e2d\u5747\u663e\u793a\u7597\u6548\uff0c\u6700\u4f73\u80bf\u7624\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe\u523048.4%\u3002" "\u8212\u6c83\u66ff\u5c3c\u539f\u521b\u7814\u7a76\u6210\u679c\u5728\u56fd\u9645\u6700\u9ad8\u7ea7\u5b66\u672f\u671f\u520aCancer Discovery\u4e0a\u53d1\u8868\u518d\u6b21\u5f70\u663e\u4e86\u8fea\u54f2\u7684\u65b0\u836f\u6e90\u5934\u521b\u65b0\u80fd\u529b\u3002\u8212\u6c83\u66ff\u5c3c\u4e34\u5e8a\u524d\u624e\u5b9e\u7684\u7814\u7a76\u548c\u4f18\u5f02\u7684\u8f6c\u5316\u79d1\u5b66\u6570\u636e\u662f\u6211\u4eec\u80fd\u591f\u5438\u5f15\u56fd\u5185\u5916\u9876\u7ea7\u80ba\u764c\u4e34\u5e8a\u4e13\u5bb6\u5408\u4f5c\u7684\u57fa\u7840\u3002\u548c\u7ade\u54c1\u76f8\u6bd4\uff0c\u8212\u6c83\u66ff\u5c3c\u5728\u4e34\u5e8a\u4e0a\u8868\u73b0\u51fa\u6765\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u4f18\u52bf\u518d\u6b21\u5f97\u5230\u5370\u8bc1\uff0c\u4e5f\u83b7\u5f97\u4e86\u4e2d\u7f8e\u4e24\u56fd\u836f\u7269\u76d1\u7ba1\u90e8\u95e8\u7684\u8ba4\u53ef\uff0c\u7ed9\u4e88\u4e86\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u3002"\u8fea\u54f2\u8463\u4e8b\u957f\u3001\u9996\u5e2d\u6267\u884c\u5b98\u5f20\u5c0f\u6797\u535a\u58eb\u8868\u793a\uff0c"\u516c\u53f8\u7684\u53d1\u5c55\u6218\u7565\u5c31\u662f\u7784\u51c6\u6076\u6027\u80bf\u7624\u3001\u514d\u75ab\u6027\u75be\u75c5\u9886\u57df\uff0c\u5229\u7528\u8f6c\u5316\u79d1\u5b66\u548c\u5206\u5b50\u8bbe\u8ba1\u7684\u4f18\u52bf\uff0c\u643a\u624b\u5168\u7403\u9876\u7ea7\u533b\u7597\u7814\u7a76\u673a\u6784\u505a\u5168\u7403\u6700\u597d\u7684\u521b\u65b0\u836f\u3002" \u516c\u53f8\u7814\u53d1\u7ba1\u7406\u56e2\u961f\u7cfb\u539f\u963f\u65af\u5229\u5eb7\u5168\u7403\u552f\u4e00\u80bf\u7624\u8f6c\u5316\u79d1\u5b66\u4e2d\u5fc3\u56e2\u961f\uff0c\u66fe\u5bf9\u963f\u65af\u5229\u5eb7\u7684\u591a\u4e2a\u91cd\u78c5\u4ea7\u54c1\u5305\u62ec\u6cf0\u745e\u6c99\u3001\u6613\u745e\u6c99\u505a\u51fa\u91cd\u5927\u8d21\u732e\u3002\u7acb\u8db3\u4e8e\u5bf9EGFR\u9886\u57df\u7684\u6df1\u523b\u7406\u89e3\uff0c\u516c\u53f8\u4eceEGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08EGFR Exon20ins NSCLC\uff09\u8fd9\u4e00\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u51fa\u53d1\uff0c\u901a\u8fc7\u5bf9EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u7684\u86cb\u767d\u7ed3\u6784\u4ee5\u53ca\u5df2\u6709EGFR-TKI\u5316\u5b66\u7ed3\u6784\u7684\u5206\u6790\uff0c\u7ecf\u8fc7\u591a\u8f6e\u8bbe\u8ba1\u3001\u5408\u6210\u3001\u6d4b\u8bd5\uff0c\u7814\u53d1\u51fa\u8212\u6c83\u66ff\u5c3c\u8fd9\u4e00\u9ad8\u6548\u3001\u9ad8\u9009\u62e9\u6027\u53ca\u5177\u6709\u826f\u597d\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u7684\u5168\u65b0\u4e00\u4ee3EGFR-TKI\uff0c\u80fd\u591f\u6709\u6548\u6291\u5236EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\uff0c\u5e76\u5bf9EGFR\u654f\u611f\u7a81\u53d8\u3001T790M\u53cc\u7a81\u53d8\u548c\u7f55\u89c1\u7a81\u53d8\u5747\u6709\u6548\uff0c\u540c\u65f6\u4fdd\u6301\u5bf9\u91ce\u751f\u578bEGFR\u7684\u9ad8\u9009\u62e9\u6027\u3002\u8212\u6c83\u66ff\u5c3c\u4e8e2019\u5e747\u6708\u5b8c\u6210\u9996\u4f8b\u53d7\u8bd5\u8005\u7ed9\u836f\uff0c\u73b0\u5904\u4e8e\u5168\u7403\u5173\u952e\u6027\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002 \u4e00\u3001\u5173\u4e8eEGFR Exon20ins NSCLC \u5728\u5168\u7403\u6076\u6027\u80bf\u7624\u5bfc\u81f4\u7684\u6b7b\u4ea1\u4e2d\uff0c\u80ba\u764c\u6392\u540d\u7b2c\u4e00\u3002\u80ba\u764c\u5206\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u548c\u5c0f\u7ec6\u80de\u80ba\u764c\u4e24\u5927\u7c7b\uff0c\u5176\u4e2d\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7ea6\u5360\u80ba\u764c\u768485%\uff0c\u800cEGFR\u7a81\u53d8\u662fNSCLC\u6700\u5e38\u89c1\u7684\u57fa\u56e0\u7a81\u53d8\u7c7b\u578b\u3002\u56fd\u9645\u4e0a\uff0c\u5409\u975e\u66ff\u5c3c\u3001\u5965\u5e0c\u66ff\u5c3c\u7b49\u7b2c\u4e00\u3001\u4e8c\u548c\u4e09\u4ee3EGFR-TKI\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u643a\u5e26EGFR\u654f\u611f\u7a81\u53d8\u3001T790M\u7a81\u53d8\u548c\u90e8\u5206\u7f55\u89c1\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u4f46EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u7531\u4e8e\u5176\u72ec\u7279\u7684\u86cb\u767d\u7ed3\u6784\uff0c\u7b2c\u4e00\u3001\u4e8c\u548c\u4e09\u4ee3EGFR-TKI\u5bf9\u5176\u6ca1\u6709\u660e\u663e\u6548\u679c\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0cNSCLC\u4e2d\u5df2\u53d1\u73b0\u591a\u79cd\u4e0d\u540c\u7684EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u4e9a\u578b\uff0c\u5404\u4e9a\u578b\u5bf9\u7279\u5b9a\u7684 EGFR TKI \u654f\u611f\u6027\u4e0d\u540c\uff0c\u56e0\u6b64\uff0c\u4e9f\u9700\u5f00\u53d1\u51fa\u80fd\u591f\u9ad8\u6548\u6291\u5236EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u5404\u7a81\u53d8\u4e9a\u578b\u7684EGFR TKI\u3002 \u4e8c\u3001\u5173\u4e8e\u8212\u6c83\u66ff\u5c3c \u8212\u6c83\u66ff\u5c3c\u9996\u9009\u9002\u5e94\u75c7\u4e3a\u6cbb\u7597EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u6b63\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6b27\u6d32\u3001\u97e9\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u65e5\u672c\u7b49\u56fd\u5bb6\u548c\u5730\u533a\u5f00\u5c55\u5173\u952e\u6027\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u662f\u7ecf\u72ec\u7acb\u5f71\u50cf\u8bc4\u5ba1\u59d4\u5458\u4f1a\u8bc4\u4f30\u7684ORR\u3002\u622a\u81f32021\u5e744\u67083\u65e5\uff0c\u5168\u7403\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u663e\u793a\uff0c\u8212\u6c83\u66ff\u5c3c\u6700\u4f73ORR\u8fbe\u523048.4%\uff0c\u5e76\u5728\u8111\u8f6c\u79fb\u60a3\u8005\u53caAmivantamab\u7597\u6548\u4e0d\u4f73\u6216\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u60a3\u8005\u4e2d\u5747\u663e\u793a\u7597\u6548\u3002\u6b64\u5916\uff0c\u8212\u6c83\u66ff\u5c3c\u5728 EGFR\u654f\u611f\u7a81\u53d8\u3001T790M\u7a81\u53d8\u548c HER2 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u4e5f\u89c2\u5bdf\u5230\u521d\u6b65\u7597\u6548\u3002 \u8212\u6c83\u66ff\u5c3c\u5177\u5907\u826f\u597d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u3002\u4eba\u4f53\u534a\u8870\u671f\u957f\u8fbe\u7ea650\u5c0f\u65f6\uff0cPK\u66f2\u7ebf\u5e73\u7f13\uff0c\u56e0\u6b64\u8fde\u7eed\u7528\u836f\u8fbe\u5230\u7a33\u6001\u65f6\u836f\u7269\u5cf0\u503c\u6d53\u5ea6\u548c\u8c37\u5e95\u6d53\u5ea6\u5dee\u8ddd\u5c0f\u3002\u4e0a\u8ff0PK\u7279\u5f81\u6709\u5229\u4e8e\u5bf9\u9776\u70b9\u7684\u6301\u7eed\u6291\u5236\uff0c\u4e14\u964d\u4f4e\u7531\u4e8e\u836f\u7269\u5cf0\u503c\u6d53\u5ea6\u8fc7\u9ad8\u5e26\u6765\u7684\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7684\u53ef\u80fd\u6027\u3002\u6b64\u5916\uff0c\u8212\u6c83\u66ff\u5c3c\u4e0e\u5df2\u83b7\u6279EGFR TKI\u76f8\u6bd4\u5177\u5907\u66f4\u597d\u7684\u5b89\u5168\u6027\uff0c\u56e0\u4e3a\u836f\u7269\u76f8\u5173\u7684TEAE\u5bfc\u81f4\u6c38\u4e45\u505c\u836f\u548c\u51cf\u5242\u91cf\u3001\u22653\u7ea7\u836f\u7269\u76f8\u5173TEAEs\u53d1\u751f\u7387\u8f83\u4f4e\u3002 \u51ed\u501f\u5176\u4f18\u5f02\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u8212\u6c83\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5df2\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3 "\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u54c1\u79cd"\u8ba4\u5b9a\u8d44\u683c\u548c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40 "\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff08Breakthrough Therapy Designation\uff09"\uff0c\u7814\u7a76\u6210\u679c\u5728\u591a\u4e2a\u56fd\u9645\u5b66\u672f\u4f1a\u8bae\uff082019AACR\u30012021ASCO\u30012021WCLC\uff09\u4e0a\u53d1\u8868\u3002 \u4e09\u3001\u5173\u4e8e\u8fea\u54f2\u533b\u836f… Read 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