{"id":67974,"date":"2022-04-19T17:00:00","date_gmt":"2022-04-19T10:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022041917000067974"},"modified":"2022-04-20T18:10:10","modified_gmt":"2022-04-20T10:10:10","slug":"%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9e%e5%9c%a8asco%e5%85%a8%e4%bd%93%e5%a4%a7%e4%bc%9a%e7%b3%bb%e5%88%97%e4%bc%9a%e8%ae%ae%e4%b8%8a%e5%85%ac%e5%b8%83%e7%99%be%e6%b3%bd%e5%ae%89r%e9%92%88%e5%af%b9","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022041917000067974","title":{"rendered":"\u767e\u6d4e\u795e\u5dde\u5728ASCO\u5168\u4f53\u5927\u4f1a\u7cfb\u5217\u4f1a\u8bae\u4e0a\u516c\u5e03\u767e\u6cfd\u5b89(R)\u9488\u5bf9\u4e00\u7ebf\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8cRATIONALE-309\u7684\u66f4\u65b0\u7ed3\u679c"},"content":{"rendered":"

\u6b64\u6b21\u6570\u636e\u5c55\u793a\u4e86\u767e\u6cfd\u5b89<\/i>®<\/sup><\/i>\u8054\u5408\u5316\u7597\u5728\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a<\/i>15.5<\/i>\u4e2a\u6708\u65f6\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u83b7\u76ca<\/i><\/p>\n

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\u4e2d\u56fd\u5317\u4eac\u3001\u7f8e\u56fd\u9ebb\u7701\u5251\u6865\u548c\u745e\u58eb\u5df4\u585e\u5c142022\u5e744\u670819\u65e5 \/\u7f8e\u901a\u793e\/ — \u767e\u6d4e\u795e\u5dde\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff1b\u4e0a\u4ea4\u6240\u4ee3\u7801\uff1a688235\uff09\u662f\u4e00\u5bb6\u7acb\u8db3\u4e8e\u79d1\u5b66\u7684\u5168\u7403\u6027\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u521b\u65b0\u3001\u53ef\u8d1f\u62c5\u7684\u836f\u7269\uff0c\u65e8\u5728\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u6548\u679c\uff0c\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u516c\u53f8\u4eca\u65e5\u5ba3\u5e03\u5c06\u5728\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5168\u4f53\u5927\u4f1a\u7cfb\u5217\u4f1a\u8bae\u4e0a\u516c\u5e033\u671f\u4e34\u5e8a\u8bd5\u9a8cRATIONALE- 309\u7684\u66f4\u65b0\u6570\u636e\u5206\u6790\u3002\u8be5\u9879\u8bd5\u9a8c\u65e8\u5728\u7814\u7a76\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\uff08RM-NPC\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

\u66f4\u65b0\u540e\u7684\u6709\u6548\u6027\u5206\u6790\u8868\u660e\uff0c\u5728\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a15.5\u4e2a\u6708\u65f6\uff0c\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u5316\u7597\u76f8\u6bd4\u4e8e\u5355\u72ec\u5316\u7597\u5728RM-NPC\u60a3\u8005\u4e2d\u4ecd\u663e\u793a\u51fa\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u83b7\u76ca\u3002\u767e\u6cfd\u5b89®<\/sup>\u548c\u5316\u7597\u8054\u5408\u7528\u836f\u7684\u5b89\u5168\u6027\u7279\u5f81\u603b\u4f53\u53ef\u63a7\uff0c\u4e14\u4e0e\u6bcf\u79cd\u6cbb\u7597\u836f\u7269\u7684\u5df2\u77e5\u98ce\u9669\u4e00\u81f4\u3002<\/p>\n

\u767e\u6d4e\u795e\u5dde\u5b9e\u4f53\u7624\u9996\u5e2d\u533b\u5b66\u5b98Mark Lanasa\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u66f4\u65b0\u6570\u636e\u5206\u6790\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u5316\u7597\u4f5c\u4e3aRM-NPC\u60a3\u8005\u7684\u6f5c\u5728\u6807\u51c6\u4e00\u7ebf\u6cbb\u7597\uff0c\u8be5\u7814\u7a76\u7684\u6570\u636e\u5206\u6790\u80fd\u591f\u5728\u5907\u53d7\u77a9\u76ee\u7684ASCO\u5168\u4f53\u5927\u4f1a\u4e0a\u8fdb\u884c\u5c55\u793a\uff0c\u8fd9\u518d\u6b21\u5370\u8bc1\u4e86\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u5316\u7597\u6709\u671b\u6210\u4e3aRM-NPC\u60a3\u8005\u7684\u6cbb\u7597\u65b0\u9009\u62e9\u3002\u201d<\/p>\n

\u57fa\u4e8e\u622a\u6b62\u65e5\u671f\u4e3a2021\u5e749\u670830\u65e5\u7684\u6700\u65b0\u6570\u636e\u5e93\uff0c\u66f4\u65b0\u5206\u6790\u4e86\u4e3b\u8981\u7ec8\u70b9\uff08PFS\uff09\u548c\u4e24\u4e2a\u6b21\u8981\u7ec8\u70b9\uff08PFS2\uff0cOS\uff09\u3002\u5728\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a15.5\u4e2a\u6708\u65f6\uff0c\u57fa\u4e8e\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRC\uff09\u7684\u8bc4\u4f30\uff0c\u63a5\u53d7200 mg\u5242\u91cf\u7684\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u5316\u7597\u7684\u60a3\u8005\u4e2d\u4f4dPFS\u4e3a9.6\u4e2a\u6708\uff08\u5206\u5c42\u98ce\u9669\u6bd4\uff08HR\uff09=0.50 [CI\uff1a0.37\uff0c0.68]\uff09\uff0c\u800c\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u5bf9\u7167\u7ec4\u60a3\u8005\u7684\u4e2d\u4f4dPFS\u4e3a7.4\u4e2a\u6708\u3002<\/p>\n

\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u534e\u5357\u80bf\u7624\u5b66\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u548c\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f20\u529b\u6559\u6388\u8868\u793a\uff1a\u201c\u6839\u636eRATIONALE-309\u8bd5\u9a8c\u7684\u66f4\u65b0\u6570\u636e\uff0c\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u5316\u7597\u5728\u665a\u671f\u9f3b\u54bd\u764c\u60a3\u8005\u4e2d\u663e\u793a\u51faPFS\u83b7\u76ca\uff0c\u540c\u65f6\u5728\u4e00\u7cfb\u5217\u5176\u4ed6\u751f\u5b58\u7ec8\u70b9\u4e2d\u4e5f\u663e\u793a\u51fa\u83b7\u76ca\u3002\u8bd5\u9a8c\u7ed3\u679c\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u5316\u7597\u4f5c\u4e3aRM-NPC\u6807\u51c6\u4e00\u7ebf\u6cbb\u7597\u7684\u6f5c\u529b\u3002\u201d<\/p>\n

\u672c\u8bd5\u9a8c\u7684\u4ea4\u53c9\u8bbe\u8ba1\u5141\u8bb8\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7ec4\u60a3\u8005\u5728\u75be\u75c5\u8fdb\u5c55\u540e\u63a5\u53d7\u767e\u6cfd\u5b89®<\/sup>\u5355\u836f\u6cbb\u7597\u3002\u8bd5\u9a8c\u8bb0\u5f55\u4e86\u81f3\u7b2c\u4e8c\u6b21\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\uff08PFS2\uff09\uff0c\u4ee5\u63a2\u7d22\u6700\u4f73\u6cbb\u7597\u987a\u5e8f\u3002\u5bf9\u4e8e\u63a5\u53d7\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u5316\u7597\u7684\u60a3\u8005\uff0c\u4e2d\u4f4dPFS2\u5c1a\u672a\u8fbe\u5230\uff0c\u800c\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7ec4\u7684\u4e2d\u4f4dPFS2\u4e3a13.9\u4e2a\u6708\uff08HR=0.38[95% CI\uff1a0.25\uff0c0.58]\uff09\u3002\u603b\u751f\u5b58\u671f\uff08OS\uff09\u5448\u6539\u5584\u8d8b\u52bf\uff0c\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u5316\u7597\u7ec4\u5c1a\u672a\u8fbe\u5230\u4e2d\u4f4dOS\uff0c\u800c\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7ec4\u7684\u4e2d\u4f4dOS\u4e3a23\u4e2a\u6708\uff08HR=0.60 [95% CI\uff1a0.25\uff0c1.01]\uff09\u3002<\/p>\n

\u9488\u5bf9\u63a2\u7d22\u6027\u7ec8\u70b9\u8fd8\u8fdb\u884c\u4e86\u751f\u7269\u6807\u5fd7\u7269\u5206\u6790\uff08\u5305\u62ecPD-L1\u548c\u57fa\u56e0\u8868\u8fbe\u8c31[GEP]\uff09\u3002\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u5316\u7597\u7ec4\u60a3\u8005\uff08\u65e0\u8bbaPD-L1\u72b6\u6001\uff09\u7684PFS\u5747\u6709\u6539\u5584\u3002GEP\u5206\u6790\u9274\u5b9a\u4e86\u4e00\u7ec4\u5177\u6709\u201c\u70ed\u201d\u80bf\u7624\u514d\u75ab\u7279\u5f81\u7684\u60a3\u8005\uff0c\u5176\u7279\u5f81\u662f\u6700\u9ad8\u6c34\u5e73\u8868\u8fbe\u514d\u75ab\u7ec6\u80de\uff0c\u5305\u62ecT\u7ec6\u80de\u3001\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u3001\u6811\u7a81\u72b6\u7ec6\u80de\u548c\u6297\u539f\u5448\u9012\u673a\u5236\u3002\u5728\u8fd9\u7ec4\u201c\u70ed\u201d\u80bf\u7624\u5fae\u73af\u5883\u7279\u5f81\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u5316\u7597\u7684\u6700\u5927PFS\u83b7\u76ca\u3002<\/p>\n

2021\u5e748\u6708\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\u4e86\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u5316\u7597\u4f5c\u4e3aRM-NPC\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u3002\u767e\u6d4e\u795e\u5dde\u5c06\u7ee7\u7eed\u652f\u6301\u8bfa\u534e\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u5bf9\u4e8e\u767e\u6cfd\u5b89®<\/sup>\u4f5c\u4e3aNPC\u4e00\u7ebf\u6cbb\u7597\u7684\u6ce8\u518c\u7533\u8bf7\u8ba1\u5212\u3002<\/p>\n

ASCO<\/b>\u5168\u4f53\u5927\u4f1a\u7cfb\u5217\u4f1a\u8bae<\/b> \u76f8\u5173\u65e5\u7a0b<\/b> <\/p>\n

2022\u5e744\u670820\u65e5\uff0c\u661f\u671f\u4e09\uff1b\u5317\u4eac\u65f6\u95f4\u65e93\u70b9 – 4\u70b9<\/p>\n

\uff082022\u5e744\u670819\u65e5\uff0c\u661f\u671f\u4e8c\uff1b\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f4\u4e0b\u53483\u70b9 – 4\u70b9\uff09<\/p>\n

\u5f20\u529b\u6559\u6388\u5c06\u5728\u672c\u6b21ASCO\u5728\u7ebf\u76f4\u64ad\u5e74\u5ea6\u5927\u4f1a\u4e0a\u62a5\u544a\u4e00\u4efd\u7814\u7a76\u6458\u8981\uff08#384950\uff09\uff0c\u6807\u9898\u4e3a\u201cRATIONALE-309\uff0c\u4e00\u9879\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u590d\u53d1\/\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u4e00\u7ebf\u6cbb\u7597\u76843\u671f\u3001\u53cc\u76f2\u8bd5\u9a8c\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u66f4\u65b0\u3001\u4e0b\u4e00\u7ebf\u6cbb\u7597\u540e\u7684PFS\u548c\u603b\u751f\u5b58\u671f\u6570\u636e\u201d\u3002\u4e0e\u4f1a\u8005\u53ef\u5728\u4ee5\u4e0b\u7f51\u7ad9\u514d\u8d39\u6ce8\u518c\uff1ahttps:\/\/www.asco.org\/meetings-education\/monthly-plenary-series\/program<\/a>\u3002<\/p>\n

\u5173\u4e8e\u9f3b\u54bd\u764c<\/b><\/p>\n

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\u5173\u4e8e<\/b>RATIONALE-309<\/b>\u4e34\u5e8a\u8bd5\u9a8c<\/b><\/p>\n

RATIONALE-309 \u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT03924986\uff09\uff0c\u65e8\u5728\u8bc4\u4f30\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u548c\u987a\u94c2\uff08A\u7ec4\uff09\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u548c\u987a\u94c2\uff08B\u7ec4\uff09\u4f5c\u4e3aRM-NPC\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n

\u8be5\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u7ecf\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRC\uff09\u6839\u636eRECIST1.1\u7248\u6807\u51c6\u8bc4\u4f30\u7684\u610f\u5411\u6027\u6cbb\u7597\uff08ITT\uff09\u4eba\u7fa4\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff1b\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u7ecfIRC\u8bc4\u4f30\u7684\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u548c\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\u3001\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3001\u7814\u7a76\u8005\u8bc4\u4f30\u7684PFS\u3001\u81f3\u7b2c\u4e8c\u6b21\u5ba2\u89c2\u75be\u75c5\u8fdb\u5c55\u65f6\u95f4\uff08PFS2\uff09\u4ee5\u53ca\u5b89\u5168\u6027\u3002<\/p>\n

\u8bd5\u9a8c\u5171\u5165\u7ec4263\u4f8b\u60a3\u8005\uff0c\u5206\u522b\u6709131\u4f8b\u548c132\u4f8b\u60a3\u8005\u968f\u673a\u5206\u914d\u81f3A\u7ec4\u548cB\u7ec4\uff0c\u4e24\u7ec4\u60a3\u8005\u7684\u57fa\u7ebf\u7279\u5f81\u5747\u8861\u3002\u8be5\u8bd5\u9a8c\u7684\u671f\u4e2d\u7ed3\u679c\u5df2\u4e8e2021\u5e7412\u6708\u5728\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u514d\u75ab\u80bf\u7624\u5b66\uff08ESMO I-O\uff09\u5927\u4f1a\u4e0a\u516c\u5e03\u3002\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0c\u5728\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a10\u4e2a\u6708\u65f6\uff0c\u4e0e\u5355\u72ec\u5316\u7597\u76f8\u6bd4\uff0c\u767e\u6cfd\u5b89®<\/sup>\u5728\u7edf\u8ba1\u5b66\u4e0a\u663e\u8457\u5ef6\u957f\u4e86\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u5728\u5176\u4ed6\u751f\u5b58\u7ec8\u70b9\u65b9\u9762\u4e5f\u663e\u793a\u51fa\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u83b7\u76ca\uff0c\u4e14\u5b89\u5168\u6027\u7279\u5f81\u603b\u4f53\u53ef\u63a7\u3002<\/p>\n

\u5173\u4e8e\u767e\u6cfd\u5b89<\/b>®<\/sup><\/b>\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09<\/b><\/p>\n

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\u767e\u6cfd\u5b89®<\/sup>\u662f\u7b2c\u4e00\u6b3e\u7531\u767e\u6d4e\u795e\u5dde\u7684\u514d\u75ab\u80bf\u7624\u751f\u7269\u5e73\u53f0\u7814\u53d1\u7684\u836f\u7269\uff0c\u76ee\u524d\u6b63\u8fdb\u884c\u5355\u836f\u53ca\u8054\u5408\u7597\u6cd5\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u5f00\u53d1\u4e00\u7cfb\u5217\u9488\u5bf9\u5b9e\u4f53\u7624\u548c\u8840\u6db2\u80bf\u7624\u7684\u5e7f\u6cdb\u9002\u5e94\u75c7\u3002\u767e\u6d4e\u795e\u5dde\u5df2\u5728\u4e2d\u56fd\u548c\u5168\u7403\u8303\u56f4\u5185\u5f00\u5c55\u6216\u5b8c\u6210\u4e8620\u591a\u9879\u767e\u6cfd\u5b89®<\/sup>\u7684\u6ce8\u518c\u53ef\u7528\u6027\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u4e2d\u5305\u62ec17\u98793\u671f\u4e34\u5e8a\u8bd5\u9a8c\u548c4\u9879\u5173\u952e\u60272\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

\u767e\u6cfd\u5b89®<\/sup>\u5df2\u88ab\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c68\u9879\u9002\u5e94\u75c7\uff0c\u5176\u4e2d\u9488\u5bf9NSCLC\u5df2\u83b7\u5f97\u591a\u9879\u6279\u51c6\u3002\u767e\u6cfd\u5b89®<\/sup>\u5728\u4e2d\u56fd\u8fd8\u6709\u53e6\u5916\u4e00\u9879\u9002\u5e94\u75c7\u5df2\u88ab\u53d7\u7406\uff0c\u76ee\u524d\u6b63\u5728\u5ba1\u8bc4\u4e2d\u3002\u767e\u6cfd\u5b89®<\/sup>\u5728\u7f8e\u56fd\u662f\u65e2\u5f80\u5168\u8eab\u6cbb\u7597\u540e\u4e0d\u53ef\u5207\u9664\u7684\u590d\u53d1\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u7684\u6f5c\u5728\u6cbb\u7597\u836f\u7269\uff0c\u5728\u6b27\u6d32\u662fNSCLC\u548cESCC\u7684\u6f5c\u5728\u6cbb\u7597\u836f\u7269\u30022021\u5e741\u6708\uff0c\u767e\u6d4e\u795e\u5dde\u4e0e\u8bfa\u534e\u8fbe\u6210\u5408\u4f5c\uff0c\u4ee5\u52a0\u901f\u767e\u6cfd\u5b89®<\/sup>\u5728\u5317\u7f8e\u3001\u6b27\u6d32\u548c\u65e5\u672c\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u3002 <\/p>\n

\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66<\/b><\/p>\n

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\u540c\u65f6\uff0c\u767e\u6d4e\u795e\u5dde\u8fd8\u4e0e\u5176\u4ed6\u521b\u65b0\u516c\u53f8\u5408\u4f5c\uff0c\u5171\u540c\u643a\u624b\u63a8\u8fdb\u521b\u65b0\u7597\u6cd5\u7684\u7814\u53d1\uff0c\u4ee5\u6ee1\u8db3\u5168\u7403\u5065\u5eb7\u9700\u6c42\u3002\u5728\u4e2d\u56fd\uff0c\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u9500\u552e\u591a\u6b3e\u7531\u5b89\u8fdb\u3001\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u3001EUSA Pharma\u3001\u767e\u5965\u6cf0\u6388\u6743\u7684\u80bf\u7624\u836f\u7269\u3002\u516c\u53f8\u4e5f\u901a\u8fc7\u4e0e\u5305\u62ecMirati Therapeutics\u3001Seagen\u4ee5\u53caZymeworks\u5728\u5185\u7684\u591a\u5bb6\u516c\u53f8\u5408\u4f5c\uff0c\u66f4\u5927\u7a0b\u5ea6\u6ee1\u8db3\u5f53\u524d\u5168\u7403\u8303\u56f4\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002<\/p>\n

2021\u5e741\u6708\uff0c\u767e\u6d4e\u795e\u5dde\u548c\u8bfa\u534e\u5ba3\u5e03\u5408\u4f5c\uff0c\u6388\u4e88\u8bfa\u534e\u5728\u5317\u7f8e\u3001\u6b27\u6d32\u548c\u65e5\u672c\u5171\u540c\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u767e\u6d4e\u795e\u5dde\u7684\u6297PD-1\u6297\u4f53\u767e\u6cfd\u5b89®<\/sup>\u3002\u57fa\u4e8e\u8fd9\u4e00\u5353\u6709\u6210\u6548\u7684\u5408\u4f5c\uff0c\u5305\u62ecFDA\u6b63\u5728\u8bc4\u5ba1\u7684\u65b0\u836f\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\uff08BLA\uff09\uff0c\u767e\u6d4e\u795e\u5dde\u548c\u8bfa\u534e\u4e8e2021\u5e7412\u6708\u5ba3\u5e03\u4e86\u5173\u4e8e\u6b63\u57283\u671f\u5f00\u53d1\u7684\u767e\u6d4e\u795e\u5ddeTIGIT\u6291\u5236\u5242\u6b27\u53f8\u73c0\u5229\u5355\u6297\u7684\u9009\u62e9\u6743\u3001\u5408\u4f5c\u548c\u8bb8\u53ef\u534f\u8bae\u3002\u8bfa\u534e\u548c\u767e\u6d4e\u795e\u5dde\u8fd8\u7b7e\u8ba2\u4e86\u4e00\u9879\u6218\u7565\u5546\u4e1a\u534f\u8bae\uff0c\u901a\u8fc7\u8be5\u534f\u8bae\uff0c\u767e\u6d4e\u795e\u5dde\u5c06\u5728\u4e2d\u56fd\u5883\u5185\u6307\u5b9a\u533a\u57df\u63a8\u5e7f5\u6b3e\u5df2\u83b7\u6279\u7684\u8bfa\u534e\u6297\u80bf\u7624\u836f\u7269\u3002 <\/p>\n

\u5173\u4e8e\u767e\u6d4e\u795e\u5dde<\/b><\/p>\n

\u767e\u6d4e\u795e\u5dde\u662f\u4e00\u5bb6\u7acb\u8db3\u4e8e\u79d1\u5b66\u7684\u5168\u7403\u6027\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u521b\u65b0\u3001\u53ef\u8d1f\u62c5\u7684\u836f\u7269\uff0c\u65e8\u5728\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u6548\u679c\u3001\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u76ee\u524d\u516c\u53f8\u5e7f\u6cdb\u7684\u836f\u7269\u7ec4\u5408\u5305\u62ec40\u591a\u6b3e\u4e34\u5e8a\u5019\u9009\u836f\u7269\u3002\u516c\u53f8\u901a\u8fc7\u52a0\u5f3a\u81ea\u4e3b\u7814\u53d1\u80fd\u529b\u548c\u5408\u4f5c\uff0c\u52a0\u901f\u63a8\u8fdb\u591a\u5143\u3001\u521b\u65b0\u7684\u836f\u7269\u7ba1\u7ebf\u5f00\u53d1\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u57282030\u5e74\u524d\u4e3a\u5168\u740320\u591a\u4ebf\u4eba\u5168\u9762\u6539\u5584\u836f\u7269\u53ef\u53ca\u6027\u3002\u767e\u6d4e\u795e\u5dde\u5728\u5168\u7403\u4e94\u5927\u6d32\u6253\u9020\u4e86\u4e00\u652f\u8d85\u8fc78,000\u4eba\u7684\u56e2\u961f\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eehttp:\/\/www.beigene.com.cn<\/a>\u3002<\/p>\n

\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n

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\u53c2\u8003\u6587\u732e\uff1a<\/b><\/p>\n[1] Global Cancer Observatory: Cancer Today. Lyon, France<\/span>: International Agency for Research on Cancer. Available at: https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/4-Nasopharynx-fact-sheet.pdf<\/a>. Accessed February 22, 2022<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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309\u7684\u66f4\u65b0\u6570\u636e\u5206\u6790\u3002\u8be5\u9879\u8bd5\u9a8c\u65e8\u5728\u7814\u7a76\u767e\u6cfd\u5b89®\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\uff08RM-NPC\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u6548\u679c\u3002 \u66f4\u65b0\u540e\u7684\u6709\u6548\u6027\u5206\u6790\u8868\u660e\uff0c\u5728\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a15.5\u4e2a\u6708\u65f6\uff0c\u767e\u6cfd\u5b89®\u8054\u5408\u5316\u7597\u76f8\u6bd4\u4e8e\u5355\u72ec\u5316\u7597\u5728RM-NPC\u60a3\u8005\u4e2d\u4ecd\u663e\u793a\u51fa\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u83b7\u76ca\u3002\u767e\u6cfd\u5b89®\u548c\u5316\u7597\u8054\u5408\u7528\u836f\u7684\u5b89\u5168\u6027\u7279\u5f81\u603b\u4f53\u53ef\u63a7\uff0c\u4e14\u4e0e\u6bcf\u79cd\u6cbb\u7597\u836f\u7269\u7684\u5df2\u77e5\u98ce\u9669\u4e00\u81f4\u3002 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