{"id":67326,"date":"2022-04-12T08:44:00","date_gmt":"2022-04-12T01:44:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022041208440067326"},"modified":"2022-04-12T18:01:05","modified_gmt":"2022-04-12T10:01:05","slug":"iii%e6%9c%9f%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6checkmate-816%e8%af%81%e5%ae%9e%ef%bc%9a%e6%9c%af%e5%89%8d%e4%bd%bf%e7%94%a8%e6%ac%a7%e7%8b%84%e6%b2%83%e8%81%94%e5%90%88%e5%8c%96%e7%96%97%e6%98%be","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022041208440067326","title":{"rendered":"III\u671f\u4e34\u5e8a\u7814\u7a76CheckMate -816\u8bc1\u5b9e\uff1a\u672f\u524d\u4f7f\u7528\u6b27\u72c4\u6c83\u8054\u5408\u5316\u7597\u663e\u8457\u6539\u5584\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f"},"content":{"rendered":"<p class=\"prntac\"><i>\u672f\u524d\u4f7f\u7528\u4e09\u4e2a\u7597\u7a0b\u6b27\u72c4\u6c83<\/i><i><sup>&reg;<\/sup><\/i><i>\u8054\u5408\u5316\u7597\uff0c\u60a3\u8005\u75be\u75c5\u8fdb\u5c55\u3001\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e<\/i><i>37%\uff0c\u540c\u65f6\u603b\u751f\u5b58\u671f\u663e\u793a\u51fa\u79ef\u6781\u7684\u65e9\u671f\u83b7\u76ca\u8d8b\u52bf<\/i><\/p>\n<p class=\"prntac\"><i>CheckMate -816\u662f\u9996\u4e2a\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u53d6\u5f97\u9633\u6027\u7ed3\u679c\u7684\u514d\u75ab\u65b0\u8f85\u52a9III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u4e5f\u662f\u7b2c\u56db\u4e2a\u8bc1\u660e\u6b27\u72c4\u6c83\u80fd\u591f\u4e3a\u65e9\u671f\u764c\u75c7\u5e26\u6765\u83b7\u76ca\u7684<\/i><i>\u7814\u7a76<\/i><\/p>\n<p class=\"prntac\"><i>\u7814\u7a76\u7ed3\u679c<\/i><i>\u4ee5\u53e3\u5934\u62a5\u544a\u7684\u5f62\u5f0f<\/i><i>\u5728<\/i><i>2022\u5e74<\/i><i>\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08<\/i><i>AACR\uff09<\/i><i>\u5e74\u4f1a<\/i><i>\u4e34\u5e8a\u7814\u7a76\u5168\u4f53\u5927\u4f1a\u4e0a\u53d1\u5e03<\/i><i>\uff0c\u5e76\u540c\u6b65\u53d1\u8868\u4e8e\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b<\/i><\/p>\n<p class=\"prntac\"><i>\u57fa\u4e8e<\/i><i>CheckMate -816\u7684\u7814\u7a76\u6570\u636e\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6279\u51c6\u6b27\u72c4\u6c83\u8054\u5408\u5316\u7597\u7528\u4e8e\u65b0\u8f85\u52a9\u6cbb\u7597\u7279\u5b9a\u53ef\u5207\u9664\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005<\/i><\/p>\n<p><p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2022\u5e744\u670812\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; <span id=\"spanHghlt5e56\">\u8fd1\u65e5\uff0c<\/span>\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08\u7ebd\u7ea6\u8bc1\u5238\u4ea4\u6613\u6240\u4ee3\u7801\uff1aBMY\uff09\u516c\u5e03\u4e86III\u671f\u4e34\u5e8a\u7814\u7a76CheckMate -816\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u7684\u6570\u636e\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5355\u7528\u5316\u7597\u76f8\u6bd4\uff0c\u53ef\u5207\u9664\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u5728\u672f\u524d\u63a5\u53d73\u4e2a\u7597\u7a0b\u7684\u6b27\u72c4\u6c83\u8054\u5408\u5316\u7597\uff0c\u53ef\u663e\u8457\u6539\u5584\u60a3\u8005EFS\u83b7\u76ca\u3002\u60a3\u8005\u968f\u673a\u5206\u7ec4\uff0c\u6700\u77ed\u968f\u8bbf21.0\u4e2a\u6708\u65f6\uff0c\u672f\u524d\u63a5\u53d7\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u7684\u60a3\u8005\u75be\u75c5\u590d\u53d1\u3001\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8637%\uff08HR 0.63\uff1b97.38% \u7f6e\u4fe1\u533a\u95f4[CI]\uff1a0.43-0.91\uff1bp=0.0052\uff09\u3002\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u60a3\u8005\u7684\u4e2d\u4f4dEFS\u4e3a31.6\u4e2a\u6708\uff0c\u800c\u5355\u7528\u5316\u7597\u7ec4\u60a3\u8005\u7684\u4e2d\u4f4dEFS\u4e3a20.8\u4e2a\u6708\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u867d\u7136\u76ee\u524d\u751f\u5b58\u6570\u636e\u5c1a\u4e0d\u6210\u719f\u4e14\u5206\u6790\u672a\u8fbe\u5230\u7edf\u8ba1\u5b66\u8fb9\u754c\uff0c\u4f46\u5728\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u60a3\u8005\u7ec4\u4e2d\u5df2\u89c2\u5bdf\u5230\u826f\u597d\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u65e9\u671f\u83b7\u76ca\u60c5\u5f62\uff08HR 0.57\uff1b99.67% \u7f6e\u4fe1\u533a\u95f4[CI]\uff1a0.30-1.07\uff09\u3002\u968f\u8bbf\u4e24\u5e74\u65f6\uff0c\u63a5\u53d7\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u65b0\u8f85\u52a9\u6cbb\u7597\u7684\u60a3\u8005\u751f\u5b58\u7387\u4e3a83%\uff0c\u5728\u5355\u7528\u5316\u7597\u60a3\u8005\u4e2d\u5219\u4e3a71%\u3002\u540e\u7eed\u4f1a\u7ee7\u7eed\u968f\u8bbfOS\u5e76\u505a\u8fdb\u4e00\u6b65\u5206\u6790\u3002<\/p>\n<p>CheckMate -816\u662f<span id=\"spanHghlte1c3\">\u9996\u4e2a<\/span>\u8bc1\u5b9e\u4ee5\u514d\u75ab\u4e3a\u57fa\u7840\u7684\u8054\u5408\u6cbb\u7597\u5728\u65b0\u8f85\u52a9\u9636\u6bb5\u80fd\u591f\u663e\u8457\u6539\u5584\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005EFS\u548c\u53e6\u4e00\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u75c5\u7406\u5b8c\u5168\u7f13\u89e3\uff08pCR\uff09\u7387\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\u3002EFS\u6570\u636e<span id=\"spanHghlt7eff\">\u4e8e<\/span>\u5317\u4eac\u65f6\u95f42022\u5e744\u670811\u65e523:15-4\u670812\u65e501:15\u57282022\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u5e74\u4f1a\u65b0\u8f85\u52a9\u548c\u56f4\u624b\u672f\u671f\u514d\u75ab\u6cbb\u7597\u4e34\u5e8a\u7814\u7a76\u5168\u4f53\u4f1a\u8bae\u4e0a\u9996\u6b21\u516c\u5e03\uff08\u6458\u8981\u7f16\u53f7#CT012\uff09\uff0c\u5e76\u540c\u6b65\u5728\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u4e0a\u53d1\u8868\u3002<\/p>\n<p>CheckMate -816\u7814\u7a76\u8005\u3001\u5df4\u9ece\u5c45\u91cc\u8499\u82cf\u91cc\u80f8\u90e8\u7814\u7a76\u6240\u6559\u6388\u3001\u6240\u957fNicolas Girard\u535a\u58eb\u8868\u793a\uff1a\u201c\u5c3d\u7ba1\u4e00\u4e9b\u53ef\u5207\u9664\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u6709\u6cbb\u6108\u53ef\u80fd\uff0c\u4f46\u5927\u90e8\u5206\u60a3\u8005\u4ecd\u7136\u9762\u4e34\u8f83\u9ad8\u7684\u672f\u540e\u590d\u53d1\u98ce\u9669\uff0c\u56e0\u6b64\u6211\u4eec\u9700\u8981\u6709\u6548\u7684\u7cfb\u7edf\u6027\u6cbb\u7597\u65b9\u6848\u6765\u9632\u6b62\u8fd9\u4e00\u60c5\u51b5\u7684\u53d1\u751f\u3002CheckMate -816 \u7684\u7814\u7a76\u7ed3\u679c\u9996\u6b21\u8bc1\u660e\uff0c\u4e0e\u5355\u7528\u5316\u7597\u76f8\u6bd4\uff0c\u4ee5\u514d\u75ab\u6cbb\u7597\u4e3a\u57fa\u7840\u7684\u8054\u5408\u65b9\u6848\u65b0\u8f85\u52a9\u6cbb\u7597\u80fd\u591f\u4e3a\u8fd9\u4e9b\u60a3\u8005\u5e26\u6765\u660e\u786e\u4e14\u663e\u8457\u7684\u83b7\u76ca\u3002\u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u9996\u5148\u89c2\u5bdf\u5230\u60a3\u8005\u7684\u75c5\u7406\u5b8c\u5168\u7f13\u89e3\u7387\u83b7\u5f97\u4e86\u6539\u5584\uff0c\u5982\u4eca\u53c8\u770b\u5230\u4e86\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\u7684\u63d0\u9ad8\uff0c\u540c\u65f6\u603b\u751f\u5b58\u671f\u4e5f\u5448\u73b0\u51fa\u4e86\u79ef\u6781\u7684\u83b7\u76ca\u8d8b\u52bf\u3002\u6211\u4eec\u6b63\u5411\u7740\u6cbb\u6108\u60a3\u8005\u7684\u6700\u7ec8\u76ee\u6807\u4e0d\u65ad\u52aa\u529b\uff0c\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u6709\u671b\u4e3a\u60a3\u8005\u5e26\u6765\u66f4\u597d\u7684\u957f\u671f\u751f\u5b58\u7ed3\u679c\u3002\u201d<\/p>\n<p>\u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u65b0\u8f85\u52a9\u6cbb\u7597\u7684\u5b89\u5168\u6027\u4e0e\u65e2\u5f80\u7814\u7a76\u62a5\u9053\u4e00\u81f4\uff0c\u5728\u5bf9EFS\u8fdb\u884c\u5206\u6790\u65f6\u672a\u89c2\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002\u4e0e\u5355\u7528\u5316\u7597\u76f8\u6bd4\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u7ec43-4\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u7684\u53d1\u751f\u7387\u4e0e\u5355\u7528\u5316\u7597\u7ec4\u76f8\u4f3c\uff0834% vs 37%\uff09\u3002\u6b64\u5916\uff0c 3-4\u7ea7\u624b\u672f\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u5728\u4e24\u7ec4\u4e2d\u7684\u53d1\u751f\u7387\u4e5f\u76f8\u4f3c\uff08\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\uff1a11%\uff0c\u5355\u7528\u5316\u7597\u7ec4\uff1a15%\uff09\u3002\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u4e2d83%\u7684\u60a3\u8005\u63a5\u53d7\u4e86\u624b\u672f\uff0c\u800c\u5355\u7528\u5316\u7597\u7ec4\u4e3a75%\u3002<\/p>\n<p>CheckMate -816\u7814\u7a76\u8005\u3001\u9ea6\u5409\u5c14\u5927\u5b66\u5916\u79d1\u5b66\u526f\u6559\u6388\u3001\u9ea6\u5409\u5c14\u5927\u5b66\u5065\u5eb7\u4e2d\u5fc3\u8499\u7279\u5229\u5c14\u603b\u533b\u9662\u80f8\u90e8\u548c\u4e0a\u6d88\u5316\u9053\u5916\u79d1\u4e3b\u6cbb\u533b\u5e08Jonathan Spicer\u8868\u793a\uff1a\u201c\u624b\u672f\u4ecd\u7136\u662f\u6cbb\u6108\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u57fa\u77f3\u3002\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u65b0\u8f85\u52a9\u6cbb\u7597\uff0c\u4f7f\u5f97\u624b\u672f\u65f6\u95f4\u66f4\u77ed\u3001\u4fb5\u5165\u6027\u66f4\u5c0f\u3001\u624b\u672f\u8303\u56f4\u66f4\u5c0f\uff0c\u540c\u65f6\u4e0d\u589e\u52a0\u5e76\u53d1\u75c7\u6216\u4e0d\u826f\u4e8b\u4ef6\uff0c\u8fd9\u5bf9\u80f8\u5916\u79d1\u533b\u751f\u53ca\u5176\u60a3\u8005\u6765\u8bf4\u90fd\u662f\u975e\u5e38\u91cd\u8981\u7684\u3002\u624b\u672f\u6cbb\u7597\u7ed3\u5c40\u7684\u83b7\u76ca\uff0c\u52a0\u4e0a\u5bf9\u60a3\u8005\u751f\u5b58\u7ed3\u679c\u7684\u6539\u5584\uff0c\u5c06\u6709\u671b\u5f7b\u5e95\u6539\u53d8\u5916\u79d1\u548c\u80bf\u7624\u79d1\u533b\u751f\u5728\u6cbb\u7597\u53ef\u5207\u9664\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u65f6\u7684\u5408\u4f5c\u65b9\u5f0f\u3002\u201d<\/p>\n<p>\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u526f\u603b\u88c1\u3001\u80f8\u90e8\u80bf\u7624\u5f00\u53d1\u8d1f\u8d23\u4ebaAbderrahim Oukessou\u535a\u58eb\u8868\u793a\uff1a\u201c\u514d\u75ab\u6cbb\u7597\u5f00\u521b\u4e86\u665a\u671f\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u65f6\u4ee3\uff0c\u6539\u53d8\u4e86\u80ba\u764c\u548c\u8bb8\u591a\u5176\u4ed6\u7c7b\u578b\u80bf\u7624\u60a3\u8005\u7684\u751f\u5b58\u9884\u671f\u3002\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u5bf9\u514d\u75ab\u7cfb\u7edf\u548c\u764c\u75c7\u751f\u7269\u5b66\u673a\u7406\u7684\u6df1\u5165\u4e86\u89e3\uff0c\u6211\u4eec\u4e0d\u65ad\u63a2\u7d22\u514d\u75ab\u6cbb\u7597\u5728\u65b0\u8f85\u52a9\u3001\u8f85\u52a9\u548c\u56f4\u624b\u672f\u671f\u7684\u4f7f\u7528\u3002\u901a\u8fc7CheckMate -816\u7684\u7814\u7a76\u6570\u636e\uff0c\u5305\u62ec\u4ee4\u4eba\u9f13\u821e\u7684\u603b\u751f\u5b58\u671f\u65e9\u671f\u7ed3\u679c\uff0c\u518d\u6b21\u8bc1\u5b9e\u4e86\u5728\u65e9\u671f\u764c\u75c7\u4e2d\u8fdb\u884c\u514d\u75ab\u6cbb\u7597\u7814\u7a76\u7684\u91cd\u8981\u6027\uff0c\u6211\u4eec\u671f\u5f85\u7ee7\u7eed\u770b\u5230\u8fd9\u4e9b\u79d1\u5b66\u7814\u7a76\u80fd\u591f\u4e3a\u60a3\u8005\u53ca\u5176\u5bb6\u4eba\u5e26\u6765\u5207\u5b9e\u83b7\u76ca\u3002\u201d<\/p>\n<p>\u57fa\u4e8eCheckMate -816\u7684EFS\u548cpCR\u7ed3\u679c\uff0c\u7f8e\u56fdFDA\u4e8e2022\u5e743\u6708\u6279\u51c6\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u542b\u94c2\u53cc\u836f\u5316\u7597\uff08\u6bcf\u4e09\u5468\u4e00\u4e2a\u7597\u7a0b\uff0c\u5171\u4e09\u4e2a\u7597\u7a0b\uff09\uff0c\u7528\u4e8e\u65b0\u8f85\u52a9\u6cbb\u7597\u80bf\u7624\u22654cm\u6216\u6dcb\u5df4\u7ed3\u9633\u6027\u7684\u53ef\u5207\u9664NSCLC\u6210\u4eba\u60a3\u8005\u3002\u5168\u7403\u8303\u56f4\u5185\u7684\u5176\u4ed6\u56fd\u5bb6\u536b\u751f\u76d1\u7ba1\u673a\u6784\u4e5f\u6b63\u5728\u5ba1\u8bc4\u8be5\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n<p>\u5728\u975e\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u9886\u57df\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u4e0e\u5408\u4f5c\u4f19\u4f34\u6b63\u5171\u540c\u63a2\u7d22\u514d\u75ab\u6cbb\u7597\u5728\u65b0\u8f85\u52a9\u3001\u8f85\u52a9\u548c\u56f4\u624b\u672f\u671f\u7684\u4f7f\u7528\uff0c\u4ee5\u53ca\u4e0e\u653e\u5316\u7597\u7684\u8054\u7528\u3002\u5728\u65b0\u8f85\u52a9\u6cbb\u7597\u9636\u6bb5\u4e2d\u4f7f\u7528\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5177\u6709\u53cc\u91cd\u79d1\u5b66\u4f9d\u636e\uff1a\u9996\u5148\uff0c\u5728\u91c7\u7528\u514d\u75ab\u6cbb\u7597\u65f6\uff0c\u80bf\u7624\u7684\u5b58\u5728\u53ef\u80fd\u4f1a\u4f7f\u514d\u75ab\u53cd\u5e94\u66f4\u5f3a\uff0c\u4ece\u800c\u6709\u671b\u4f7f\u9488\u5bf9\u539f\u53d1\u80bf\u7624\u7684\u6cbb\u7597\u66f4\u6709\u6548\u3002\u5176\u6b21\uff0c\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5c06\u6709\u673a\u4f1a\u6e05\u9664\u9690\u853d\u7684\u5fae\u8f6c\u79fb\u7076\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u6b27\u72c4\u6c83\u4f5c\u4e3a\u65b0\u8f85\u52a9\u6216\u8f85\u52a9\u6cbb\u7597\u5df2\u5728\u56db\u79cd\u80bf\u7624\u7c7b\u578b\u4e2d\u663e\u793a\u51fa\u4e86\u7597\u6548\u6539\u5584\uff0c\u5305\u62ec\u80ba\u764c\u3001\u8180\u80f1\u764c\u3001\u98df\u7ba1\u764c\/\u80c3\u98df\u7ba1\u8fde\u63a5\u90e8\u764c\u548c\u9ed1\u8272\u7d20\u7624\u3002<\/p>\n<p>\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u5bf9\u53c2\u4e0e CheckMate -816 \u4e34\u5e8a\u8bd5\u9a8c\u7684\u60a3\u8005\u548c\u7814\u7a76\u4eba\u5458\u8868\u793a\u8bda\u631a\u8c22\u610f\u3002<\/p>\n<p><i>\uff08\u76ee\u524d\u8be5\u9002\u5e94\u75c7\u5c1a\u672a\u5728\u4e2d\u56fd\u83b7\u6279\u3002\u672c\u8d44\u6599\u4e2d\u6d89\u53ca\u7684\u4fe1\u606f\u4ec5\u4f9b\u53c2\u8003\uff0c\u8bf7\u9075\u4ece\u533b\u751f\u6216\u5176\u4ed6\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u6216\u6307\u5bfc\uff09<\/i><\/p>\n<p><b><u>\u5173\u4e8e<\/u><\/b><b><u>CheckMate -816<\/u><\/b><\/p>\n<p>CheckMate -816\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u4e0e\u5355\u7528\u5316\u7597\u76f8\u6bd4\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u65b0\u8f85\u52a9\u6cbb\u7597\u7528\u4e8e\u53ef\u5207\u9664IB\u671f\u81f3IIIA\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u7597\u6548\uff08\u6839\u636e\u7b2c7\u7248AJCC\/UICC\u5206\u671f\u6807\u51c6\uff09\uff0c\u4e0d\u8bba\u60a3\u8005\u80bf\u7624PD-L1\u8868\u8fbe\u6c34\u5e73\u3002\u5728\u4e3b\u8981\u5206\u6790\u4e2d\uff0c358\u4f8b\u60a3\u8005\u5728\u672f\u524d\u968f\u673a\u63a5\u53d7\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff08360mg\uff09\u8054\u5408\u57fa\u4e8e\u7ec4\u7ec7\u5b66\u5206\u578b\u7684\u542b\u94c2\u53cc\u836f\u5316\u7597\uff08\u6bcf3\u5468\u4e00\u4e2a\u7597\u7a0b\uff0c\u51713\u4e2a\u7597\u7a0b\uff09\uff0c\u6216\u8005\u5355\u7528\u542b\u94c2\u53cc\u836f\u5316\u7597\uff08\u6bcf3\u5468\u4e00\u4e2a\u7597\u7a0b\uff0c\u51713\u4e2a\u7597\u7a0b\uff09\uff0c\u4e4b\u540e\u8fdb\u884c\u624b\u672f\u6cbb\u7597\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\u548c\u75c5\u7406\u5b8c\u5168\u7f13\u89e3\u7387\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u603b\u751f\u5b58\u671f\u3001\u4e3b\u8981\u75c5\u7406\u7f13\u89e3\u7387\u4ee5\u53ca\u81f3\u6b7b\u4ea1\u6216\u8fdc\u5904\u8f6c\u79fb\u7684\u65f6\u95f4\u3002<\/p>\n<p><b><u>\u5173\u4e8e\u80ba\u764c<\/u><\/b><\/p>\n<p>\u80ba\u764c\u662f\u5168\u7403\u764c\u75c7\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u662f\u6700\u4e3a\u5e38\u89c1\u7684\u80ba\u764c\u7c7b\u578b\uff0c\u5360\u6240\u6709\u786e\u8bca\u75c5\u4f8b\u768484%\u3002\u5927\u90e8\u5206NSCLC\u60a3\u8005\uff08\u7ea660%\uff09\u5728\u8bca\u65ad\u65f6\u5c1a\u672a\u53d1\u751f\u8f6c\u79fb\uff0c\u5176\u4e2d\u591a\u8fbe\u4e00\u534a\u662f\u53ef\u5207\u9664\u7684\u3002\u968f\u7740\u7b5b\u67e5\u7684\u52a0\u5f3a\uff0c\u8fd9\u4e00\u6bd4\u4f8b\u9884\u8ba1\u4f1a\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u63d0\u9ad8\u3002\u5c3d\u7ba1\u8bb8\u591a\u975e\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u53ef\u4ee5\u901a\u8fc7\u624b\u672f\u6cbb\u6108\uff0c\u4f46\u4ecd\u670930%\u81f355%\u7684\u60a3\u8005\u4f1a\u5728\u672f\u540e\u590d\u53d1\u548c\u6b7b\u4e8e\u75be\u75c5\u3002\u56e0\u6b64\u9700\u8981\u591a\u79cd\u6cbb\u7597\u9009\u62e9\uff0c\u5305\u62ec\u672f\u524d\uff08\u65b0\u8f85\u52a9\u6cbb\u7597\uff09\u548c\/\u6216\u672f\u540e\uff08\u8f85\u52a9\u6cbb\u7597\uff09\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u7684\u957f\u671f\u751f\u5b58\u3002<\/p>\n<p><b><u>\u5173\u4e8e\u6b27\u72c4\u6c83<\/u><\/b><\/p>\n<p>\u6b27\u72c4\u6c83\u662f\u4e00\u79cdPD-1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u72ec\u7279\u5730\u5229\u7528\u4eba\u4f53\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u6765\u5e2e\u52a9\u673a\u4f53\u6062\u590d\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u79cd\u901a\u8fc7\u5229\u7528\u4eba\u4f53\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\u6765\u6297\u51fb\u764c\u75c7\u7684\u7279\u6027\uff0c\u4f7f\u6b27\u72c4\u6c83\u5df2\u6210\u4e3a\u591a\u7624\u79cd\u7684\u91cd\u8981\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n<p>\u57fa\u4e8e\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u5728\u514d\u75ab\u80bf\u7624\uff08I-O\uff09\u6cbb\u7597\u9886\u57df\u7684\u79d1\u5b66\u4e13\u957f\uff0c\u6b27\u72c4\u6c83\u62e5\u6709\u5168\u7403\u9886\u5148\u7684\u7814\u53d1\u9879\u76ee\uff0c\u6db5\u76d6\u591a\u7624\u79cd\u7684\u5404\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5305\u62ec\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u622a\u81f3\u76ee\u524d\uff0c\u5df2\u6709\u8d85\u8fc735,000\u540d\u60a3\u8005\u5728\u6b27\u72c4\u6c83\u7684\u4e34\u5e8a\u7814\u53d1\u9879\u76ee\u4e2d\u63a5\u53d7\u4e86\u6b27\u72c4\u6c83\u7684\u6cbb\u7597\u3002\u6b27\u72c4\u6c83\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6709\u52a9\u4e8e\u52a0\u6df1\u7406\u89e3\u751f\u7269\u6807\u5fd7\u7269\u5bf9\u60a3\u8005\u6cbb\u7597\u9009\u62e9\u7684\u6f5c\u5728\u63d0\u793a\u4f5c\u7528\uff0c\u7279\u522b\u662f\u8bc6\u522b\u4e0d\u540cPD-L1\u8868\u8fbe\u6c34\u5e73\u7684\u60a3\u8005\u5982\u4f55\u80fd\u591f\u4ece\u6b27\u72c4\u6c83\u4e2d\u83b7\u76ca\u3002<\/p>\n<p>2014\u5e747\u6708\uff0c\u6b27\u72c4\u6c83\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u83b7\u5f97\u76d1\u7ba1\u673a\u6784\u6279\u51c6\u7684PD-1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u76ee\u524d\u6b27\u72c4\u6c83\u5df2\u5728\u8d85\u8fc765\u4e2a\u56fd\u5bb6\u6216\u5730\u533a\u83b7\u5f97\u6279\u51c6\uff0c\u5305\u62ec\u7f8e\u56fd\u3001\u6b27\u76df\u3001\u65e5\u672c\u548c\u4e2d\u56fd\u3002\u7ee72015\u5e7410\u6708\uff0c\u6b27\u72c4\u6c83&reg;\uff08\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u8054\u5408\u9038\u6c83<sup>&reg;<\/sup>\uff08\u4f0a\u5339\u6728\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u9996\u6b21\u83b7\u5f97\u76d1\u7ba1\u673a\u6784\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u540e\uff0c\u76ee\u524d\u8be5\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5df2\u5728\u8d85\u8fc750\u4e2a\u56fd\u5bb6\u6216\u5730\u533a\u83b7\u5f97\u6279\u51c6\uff0c\u5305\u62ec\u7f8e\u56fd\u3001\u6b27\u76df\u548c\u4e2d\u56fd\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u672f\u524d\u4f7f\u7528\u4e09\u4e2a\u7597\u7a0b\u6b27\u72c4\u6c83&reg;\u8054\u5408\u5316\u7597\uff0c\u60a3\u8005\u75be\u75c5\u8fdb\u5c55\u3001\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e37%\uff0c\u540c\u65f6\u603b\u751f\u5b58\u671f\u663e\u793a\u51fa\u79ef\u6781\u7684\u65e9\u671f\u83b7\u76ca\u8d8b\u52bf CheckMate -816\u662f\u9996\u4e2a\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u53d6\u5f97\u9633\u6027\u7ed3\u679c\u7684\u514d\u75ab\u65b0\u8f85\u52a9III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u4e5f\u662f\u7b2c\u56db\u4e2a\u8bc1\u660e\u6b27\u72c4\u6c83\u80fd\u591f\u4e3a\u65e9\u671f\u764c\u75c7\u5e26\u6765\u83b7\u76ca\u7684\u7814\u7a76 \u7814\u7a76\u7ed3\u679c\u4ee5\u53e3\u5934\u62a5\u544a\u7684\u5f62\u5f0f\u57282022\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u5e74\u4f1a\u4e34\u5e8a\u7814\u7a76\u5168\u4f53\u5927\u4f1a\u4e0a\u53d1\u5e03\uff0c\u5e76\u540c\u6b65\u53d1\u8868\u4e8e\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b \u57fa\u4e8eCheckMate -816\u7684\u7814\u7a76\u6570\u636e\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6279\u51c6\u6b27\u72c4\u6c83\u8054\u5408\u5316\u7597\u7528\u4e8e\u65b0\u8f85\u52a9\u6cbb\u7597\u7279\u5b9a\u53ef\u5207\u9664\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005 \u4e0a\u6d772022\u5e744\u670812\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u8fd1\u65e5\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08\u7ebd\u7ea6\u8bc1\u5238\u4ea4\u6613\u6240\u4ee3\u7801\uff1aBMY\uff09\u516c\u5e03\u4e86III\u671f\u4e34\u5e8a\u7814\u7a76CheckMate -816\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u7684\u6570\u636e\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5355\u7528\u5316\u7597\u76f8\u6bd4\uff0c\u53ef\u5207\u9664\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u5728\u672f\u524d\u63a5\u53d73\u4e2a\u7597\u7a0b\u7684\u6b27\u72c4\u6c83\u8054\u5408\u5316\u7597\uff0c\u53ef\u663e\u8457\u6539\u5584\u60a3\u8005EFS\u83b7\u76ca\u3002\u60a3\u8005\u968f\u673a\u5206\u7ec4\uff0c\u6700\u77ed\u968f\u8bbf21.0\u4e2a\u6708\u65f6\uff0c\u672f\u524d\u63a5\u53d7\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u7684\u60a3\u8005\u75be\u75c5\u590d\u53d1\u3001\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8637%\uff08HR 0.63\uff1b97.38% \u7f6e\u4fe1\u533a\u95f4[CI]\uff1a0.43-0.91\uff1bp=0.0052\uff09\u3002\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u60a3\u8005\u7684\u4e2d\u4f4dEFS\u4e3a31.6\u4e2a\u6708\uff0c\u800c\u5355\u7528\u5316\u7597\u7ec4\u60a3\u8005\u7684\u4e2d\u4f4dEFS\u4e3a20.8\u4e2a\u6708\u3002 \u6b64\u5916\uff0c\u867d\u7136\u76ee\u524d\u751f\u5b58\u6570\u636e\u5c1a\u4e0d\u6210\u719f\u4e14\u5206\u6790\u672a\u8fbe\u5230\u7edf\u8ba1\u5b66\u8fb9\u754c\uff0c\u4f46\u5728\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u60a3\u8005\u7ec4\u4e2d\u5df2\u89c2\u5bdf\u5230\u826f\u597d\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u65e9\u671f\u83b7\u76ca\u60c5\u5f62\uff08HR 0.57\uff1b99.67% \u7f6e\u4fe1\u533a\u95f4[CI]\uff1a0.30-1.07\uff09\u3002\u968f\u8bbf\u4e24\u5e74\u65f6\uff0c\u63a5\u53d7\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u65b0\u8f85\u52a9\u6cbb\u7597\u7684\u60a3\u8005\u751f\u5b58\u7387\u4e3a83%\uff0c\u5728\u5355\u7528\u5316\u7597\u60a3\u8005\u4e2d\u5219\u4e3a71%\u3002\u540e\u7eed\u4f1a\u7ee7\u7eed\u968f\u8bbfOS\u5e76\u505a\u8fdb\u4e00\u6b65\u5206\u6790\u3002 CheckMate -816\u662f\u9996\u4e2a\u8bc1\u5b9e\u4ee5\u514d\u75ab\u4e3a\u57fa\u7840\u7684\u8054\u5408\u6cbb\u7597\u5728\u65b0\u8f85\u52a9\u9636\u6bb5\u80fd\u591f\u663e\u8457\u6539\u5584\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005EFS\u548c\u53e6\u4e00\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u75c5\u7406\u5b8c\u5168\u7f13\u89e3\uff08pCR\uff09\u7387\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\u3002EFS\u6570\u636e\u4e8e\u5317\u4eac\u65f6\u95f42022\u5e744\u670811\u65e523:15-4\u670812\u65e501:15\u57282022\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u5e74\u4f1a\u65b0\u8f85\u52a9\u548c\u56f4\u624b\u672f\u671f\u514d\u75ab\u6cbb\u7597\u4e34\u5e8a\u7814\u7a76\u5168\u4f53\u4f1a\u8bae\u4e0a\u9996\u6b21\u516c\u5e03\uff08\u6458\u8981\u7f16\u53f7#CT012\uff09\uff0c\u5e76\u540c\u6b65\u5728\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u4e0a\u53d1\u8868\u3002 CheckMate -816\u7814\u7a76\u8005\u3001\u5df4\u9ece\u5c45\u91cc\u8499\u82cf\u91cc\u80f8\u90e8\u7814\u7a76\u6240\u6559\u6388\u3001\u6240\u957fNicolas Girard\u535a\u58eb\u8868\u793a\uff1a\u201c\u5c3d\u7ba1\u4e00\u4e9b\u53ef\u5207\u9664\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u6709\u6cbb\u6108\u53ef\u80fd\uff0c\u4f46\u5927\u90e8\u5206\u60a3\u8005\u4ecd\u7136\u9762\u4e34\u8f83\u9ad8\u7684\u672f\u540e\u590d\u53d1\u98ce\u9669\uff0c\u56e0\u6b64\u6211\u4eec\u9700\u8981\u6709\u6548\u7684\u7cfb\u7edf\u6027\u6cbb\u7597\u65b9\u6848\u6765\u9632\u6b62\u8fd9\u4e00\u60c5\u51b5\u7684\u53d1\u751f\u3002CheckMate -816 \u7684\u7814\u7a76\u7ed3\u679c\u9996\u6b21\u8bc1\u660e\uff0c\u4e0e\u5355\u7528\u5316\u7597\u76f8\u6bd4\uff0c\u4ee5\u514d\u75ab\u6cbb\u7597\u4e3a\u57fa\u7840\u7684\u8054\u5408\u65b9\u6848\u65b0\u8f85\u52a9\u6cbb\u7597\u80fd\u591f\u4e3a\u8fd9\u4e9b\u60a3\u8005\u5e26\u6765\u660e\u786e\u4e14\u663e\u8457\u7684\u83b7\u76ca\u3002\u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u9996\u5148\u89c2\u5bdf\u5230\u60a3\u8005\u7684\u75c5\u7406\u5b8c\u5168\u7f13\u89e3\u7387\u83b7\u5f97\u4e86\u6539\u5584\uff0c\u5982\u4eca\u53c8\u770b\u5230\u4e86\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\u7684\u63d0\u9ad8\uff0c\u540c\u65f6\u603b\u751f\u5b58\u671f\u4e5f\u5448\u73b0\u51fa\u4e86\u79ef\u6781\u7684\u83b7\u76ca\u8d8b\u52bf\u3002\u6211\u4eec\u6b63\u5411\u7740\u6cbb\u6108\u60a3\u8005\u7684\u6700\u7ec8\u76ee\u6807\u4e0d\u65ad\u52aa\u529b\uff0c\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u6709\u671b\u4e3a\u60a3\u8005\u5e26\u6765\u66f4\u597d\u7684\u957f\u671f\u751f\u5b58\u7ed3\u679c\u3002\u201d \u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u65b0\u8f85\u52a9\u6cbb\u7597\u7684\u5b89\u5168\u6027\u4e0e\u65e2\u5f80\u7814\u7a76\u62a5\u9053\u4e00\u81f4\uff0c\u5728\u5bf9EFS\u8fdb\u884c\u5206\u6790\u65f6\u672a\u89c2\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002\u4e0e\u5355\u7528\u5316\u7597\u76f8\u6bd4\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u7ec43-4\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u7684\u53d1\u751f\u7387\u4e0e\u5355\u7528\u5316\u7597\u7ec4\u76f8\u4f3c\uff0834% vs 37%\uff09\u3002\u6b64\u5916\uff0c 3-4\u7ea7\u624b\u672f\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u5728\u4e24\u7ec4\u4e2d\u7684\u53d1\u751f\u7387\u4e5f\u76f8\u4f3c\uff08\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\uff1a11%\uff0c\u5355\u7528\u5316\u7597\u7ec4\uff1a15%\uff09\u3002\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u4e2d83%\u7684\u60a3\u8005\u63a5\u53d7\u4e86\u624b\u672f\uff0c\u800c\u5355\u7528\u5316\u7597\u7ec4\u4e3a75%\u3002 CheckMate -816\u7814\u7a76\u8005\u3001\u9ea6\u5409\u5c14\u5927\u5b66\u5916\u79d1\u5b66\u526f\u6559\u6388\u3001\u9ea6\u5409\u5c14\u5927\u5b66\u5065\u5eb7\u4e2d\u5fc3\u8499\u7279\u5229\u5c14\u603b\u533b\u9662\u80f8\u90e8\u548c\u4e0a\u6d88\u5316\u9053\u5916\u79d1\u4e3b\u6cbb\u533b\u5e08Jonathan Spicer\u8868\u793a\uff1a\u201c\u624b\u672f\u4ecd\u7136\u662f\u6cbb\u6108\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u57fa\u77f3\u3002\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u65b0\u8f85\u52a9\u6cbb\u7597\uff0c\u4f7f\u5f97\u624b\u672f\u65f6\u95f4\u66f4\u77ed\u3001\u4fb5\u5165\u6027\u66f4\u5c0f\u3001\u624b\u672f\u8303\u56f4\u66f4\u5c0f\uff0c\u540c\u65f6\u4e0d\u589e\u52a0\u5e76\u53d1\u75c7\u6216\u4e0d\u826f\u4e8b\u4ef6\uff0c\u8fd9\u5bf9\u80f8\u5916\u79d1\u533b\u751f\u53ca\u5176\u60a3\u8005\u6765\u8bf4\u90fd\u662f\u975e\u5e38\u91cd\u8981\u7684\u3002\u624b\u672f\u6cbb\u7597\u7ed3\u5c40\u7684\u83b7\u76ca\uff0c\u52a0\u4e0a\u5bf9\u60a3\u8005\u751f\u5b58\u7ed3\u679c\u7684\u6539\u5584\uff0c\u5c06\u6709\u671b\u5f7b\u5e95\u6539\u53d8\u5916\u79d1\u548c\u80bf\u7624\u79d1\u533b\u751f\u5728\u6cbb\u7597\u53ef\u5207\u9664\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u65f6\u7684\u5408\u4f5c\u65b9\u5f0f\u3002\u201d \u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u526f\u603b\u88c1\u3001\u80f8\u90e8\u80bf\u7624\u5f00\u53d1\u8d1f\u8d23\u4ebaAbderrahim Oukessou\u535a\u58eb\u8868\u793a\uff1a\u201c\u514d\u75ab\u6cbb\u7597\u5f00\u521b\u4e86\u665a\u671f\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u65f6\u4ee3\uff0c\u6539\u53d8\u4e86\u80ba\u764c\u548c\u8bb8\u591a\u5176\u4ed6\u7c7b\u578b\u80bf\u7624\u60a3\u8005\u7684\u751f\u5b58\u9884\u671f\u3002\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u5bf9\u514d\u75ab\u7cfb\u7edf\u548c\u764c\u75c7\u751f\u7269\u5b66\u673a\u7406\u7684\u6df1\u5165\u4e86\u89e3\uff0c\u6211\u4eec\u4e0d\u65ad\u63a2\u7d22\u514d\u75ab\u6cbb\u7597\u5728\u65b0\u8f85\u52a9\u3001\u8f85\u52a9\u548c\u56f4\u624b\u672f\u671f\u7684\u4f7f\u7528\u3002\u901a\u8fc7CheckMate -816\u7684\u7814\u7a76\u6570\u636e\uff0c\u5305\u62ec\u4ee4\u4eba\u9f13\u821e\u7684\u603b\u751f\u5b58\u671f\u65e9\u671f\u7ed3\u679c\uff0c\u518d\u6b21\u8bc1\u5b9e\u4e86\u5728\u65e9\u671f\u764c\u75c7\u4e2d\u8fdb\u884c\u514d\u75ab\u6cbb\u7597\u7814\u7a76\u7684\u91cd\u8981\u6027\uff0c\u6211\u4eec\u671f\u5f85\u7ee7\u7eed\u770b\u5230\u8fd9\u4e9b\u79d1\u5b66\u7814\u7a76\u80fd\u591f\u4e3a\u60a3\u8005\u53ca\u5176\u5bb6\u4eba\u5e26\u6765\u5207\u5b9e\u83b7\u76ca\u3002\u201d \u57fa\u4e8eCheckMate -816\u7684EFS\u548cpCR\u7ed3\u679c\uff0c\u7f8e\u56fdFDA\u4e8e2022\u5e743\u6708\u6279\u51c6\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u542b\u94c2\u53cc\u836f\u5316\u7597\uff08\u6bcf\u4e09\u5468\u4e00\u4e2a\u7597\u7a0b\uff0c\u5171\u4e09\u4e2a\u7597\u7a0b\uff09\uff0c\u7528\u4e8e\u65b0\u8f85\u52a9\u6cbb\u7597\u80bf\u7624\u22654cm\u6216\u6dcb\u5df4\u7ed3\u9633\u6027\u7684\u53ef\u5207\u9664NSCLC\u6210\u4eba\u60a3\u8005\u3002\u5168\u7403\u8303\u56f4\u5185\u7684\u5176\u4ed6\u56fd\u5bb6\u536b\u751f\u76d1\u7ba1\u673a\u6784\u4e5f\u6b63\u5728\u5ba1\u8bc4\u8be5\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u3002 \u5728\u975e\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u9886\u57df\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u4e0e\u5408\u4f5c\u4f19\u4f34\u6b63\u5171\u540c\u63a2\u7d22\u514d\u75ab\u6cbb\u7597\u5728\u65b0\u8f85\u52a9\u3001\u8f85\u52a9\u548c\u56f4\u624b\u672f\u671f\u7684\u4f7f\u7528\uff0c\u4ee5\u53ca\u4e0e\u653e\u5316\u7597\u7684\u8054\u7528\u3002\u5728\u65b0\u8f85\u52a9\u6cbb\u7597\u9636\u6bb5\u4e2d\u4f7f\u7528\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5177\u6709\u53cc\u91cd\u79d1\u5b66\u4f9d\u636e\uff1a\u9996\u5148\uff0c\u5728\u91c7\u7528\u514d\u75ab\u6cbb\u7597\u65f6\uff0c\u80bf\u7624\u7684\u5b58\u5728\u53ef\u80fd\u4f1a\u4f7f\u514d\u75ab\u53cd\u5e94\u66f4\u5f3a\uff0c\u4ece\u800c\u6709\u671b\u4f7f\u9488\u5bf9\u539f\u53d1\u80bf\u7624\u7684\u6cbb\u7597\u66f4\u6709\u6548\u3002\u5176\u6b21\uff0c\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5c06\u6709\u673a\u4f1a\u6e05\u9664\u9690\u853d\u7684\u5fae\u8f6c\u79fb\u7076\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u6b27\u72c4\u6c83\u4f5c\u4e3a\u65b0\u8f85\u52a9\u6216\u8f85\u52a9\u6cbb\u7597\u5df2\u5728\u56db\u79cd\u80bf\u7624\u7c7b\u578b\u4e2d\u663e\u793a\u51fa\u4e86\u7597\u6548\u6539\u5584\uff0c\u5305\u62ec\u80ba\u764c\u3001\u8180\u80f1\u764c\u3001\u98df\u7ba1\u764c\/\u80c3\u98df\u7ba1\u8fde\u63a5\u90e8\u764c\u548c\u9ed1\u8272\u7d20\u7624\u3002 \u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u5bf9\u53c2\u4e0e CheckMate -816 \u4e34\u5e8a\u8bd5\u9a8c\u7684\u60a3\u8005\u548c\u7814\u7a76\u4eba\u5458\u8868\u793a\u8bda\u631a\u8c22\u610f\u3002 \uff08\u76ee\u524d\u8be5\u9002\u5e94\u75c7\u5c1a\u672a\u5728\u4e2d\u56fd\u83b7\u6279\u3002\u672c\u8d44\u6599\u4e2d\u6d89\u53ca\u7684\u4fe1\u606f\u4ec5\u4f9b\u53c2\u8003\uff0c\u8bf7\u9075\u4ece\u533b\u751f\u6216\u5176\u4ed6\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u6216\u6307\u5bfc\uff09 \u5173\u4e8eCheckMate -816 CheckMate -816\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u4e0e\u5355\u7528\u5316\u7597\u76f8\u6bd4\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u65b0\u8f85\u52a9\u6cbb\u7597\u7528\u4e8e\u53ef\u5207\u9664IB\u671f\u81f3IIIA\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u7597\u6548\uff08\u6839\u636e\u7b2c7\u7248AJCC\/UICC\u5206\u671f\u6807\u51c6\uff09\uff0c\u4e0d\u8bba\u60a3\u8005\u80bf\u7624PD-L1\u8868\u8fbe\u6c34\u5e73\u3002\u5728\u4e3b\u8981\u5206\u6790\u4e2d\uff0c358\u4f8b\u60a3\u8005\u5728\u672f\u524d\u968f\u673a\u63a5\u53d7\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff08360mg\uff09\u8054\u5408\u57fa\u4e8e\u7ec4\u7ec7\u5b66\u5206\u578b\u7684\u542b\u94c2\u53cc\u836f\u5316\u7597\uff08\u6bcf3\u5468\u4e00\u4e2a\u7597\u7a0b\uff0c\u51713\u4e2a\u7597\u7a0b\uff09\uff0c\u6216\u8005\u5355\u7528\u542b\u94c2\u53cc\u836f\u5316\u7597\uff08\u6bcf3\u5468\u4e00\u4e2a\u7597\u7a0b\uff0c\u51713\u4e2a\u7597\u7a0b\uff09\uff0c\u4e4b\u540e\u8fdb\u884c\u624b\u672f\u6cbb\u7597\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\u548c\u75c5\u7406\u5b8c\u5168\u7f13\u89e3\u7387\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u603b\u751f\u5b58\u671f\u3001\u4e3b\u8981\u75c5\u7406\u7f13\u89e3\u7387\u4ee5\u53ca\u81f3\u6b7b\u4ea1\u6216\u8fdc\u5904\u8f6c\u79fb\u7684\u65f6\u95f4\u3002 \u5173\u4e8e\u80ba\u764c \u80ba\u764c\u662f\u5168\u7403\u764c\u75c7\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u662f\u6700\u4e3a\u5e38\u89c1\u7684\u80ba\u764c\u7c7b\u578b\uff0c\u5360\u6240\u6709\u786e\u8bca\u75c5\u4f8b\u768484%\u3002\u5927\u90e8\u5206NSCLC\u60a3\u8005\uff08\u7ea660%\uff09\u5728\u8bca\u65ad\u65f6\u5c1a\u672a\u53d1\u751f\u8f6c\u79fb\uff0c\u5176\u4e2d\u591a\u8fbe\u4e00\u534a\u662f\u53ef\u5207\u9664\u7684\u3002\u968f\u7740\u7b5b\u67e5\u7684\u52a0\u5f3a\uff0c\u8fd9\u4e00\u6bd4\u4f8b\u9884\u8ba1\u4f1a\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u63d0\u9ad8\u3002\u5c3d\u7ba1\u8bb8\u591a\u975e\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u53ef\u4ee5\u901a\u8fc7\u624b\u672f\u6cbb\u6108\uff0c\u4f46\u4ecd\u670930%\u81f355%\u7684\u60a3\u8005\u4f1a\u5728\u672f\u540e\u590d\u53d1\u548c\u6b7b\u4e8e\u75be\u75c5\u3002\u56e0\u6b64\u9700\u8981\u591a\u79cd\u6cbb\u7597\u9009\u62e9\uff0c\u5305\u62ec\u672f\u524d\uff08\u65b0\u8f85\u52a9\u6cbb\u7597\uff09\u548c\/\u6216\u672f\u540e\uff08\u8f85\u52a9\u6cbb\u7597\uff09\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u7684\u957f\u671f\u751f\u5b58\u3002 \u5173\u4e8e\u6b27\u72c4\u6c83 \u6b27\u72c4\u6c83\u662f\u4e00\u79cdPD-1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u72ec\u7279\u5730\u5229\u7528\u4eba\u4f53\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u6765\u5e2e\u52a9\u673a\u4f53\u6062\u590d\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u79cd\u901a\u8fc7\u5229\u7528\u4eba\u4f53\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\u6765\u6297\u51fb\u764c\u75c7\u7684\u7279\u6027\uff0c\u4f7f\u6b27\u72c4\u6c83\u5df2\u6210\u4e3a\u591a\u7624\u79cd\u7684\u91cd\u8981\u6cbb\u7597\u9009\u62e9\u3002 \u57fa\u4e8e\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u5728\u514d\u75ab\u80bf\u7624\uff08I-O\uff09\u6cbb\u7597\u9886\u57df\u7684\u79d1\u5b66\u4e13\u957f\uff0c\u6b27\u72c4\u6c83\u62e5\u6709\u5168\u7403\u9886\u5148\u7684\u7814\u53d1\u9879\u76ee\uff0c\u6db5\u76d6\u591a\u7624\u79cd\u7684\u5404\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5305\u62ec\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u622a\u81f3\u76ee\u524d\uff0c\u5df2\u6709\u8d85\u8fc735,000\u540d\u60a3\u8005\u5728\u6b27\u72c4\u6c83\u7684\u4e34\u5e8a\u7814\u53d1\u9879\u76ee\u4e2d\u63a5\u53d7\u4e86\u6b27\u72c4\u6c83\u7684\u6cbb\u7597\u3002\u6b27\u72c4\u6c83\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6709\u52a9\u4e8e\u52a0\u6df1\u7406\u89e3\u751f\u7269\u6807\u5fd7\u7269\u5bf9\u60a3\u8005\u6cbb\u7597\u9009\u62e9\u7684\u6f5c\u5728\u63d0\u793a\u4f5c\u7528\uff0c\u7279\u522b\u662f\u8bc6\u522b\u4e0d\u540cPD-L1\u8868\u8fbe\u6c34\u5e73\u7684\u60a3\u8005\u5982\u4f55\u80fd\u591f\u4ece\u6b27\u72c4\u6c83\u4e2d\u83b7\u76ca\u3002 2014\u5e747\u6708\uff0c\u6b27\u72c4\u6c83\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u83b7\u5f97\u76d1\u7ba1\u673a\u6784\u6279\u51c6\u7684PD-1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u76ee\u524d\u6b27\u72c4\u6c83\u5df2\u5728\u8d85\u8fc765\u4e2a\u56fd\u5bb6\u6216\u5730\u533a\u83b7\u5f97\u6279\u51c6\uff0c\u5305\u62ec\u7f8e\u56fd\u3001\u6b27\u76df\u3001\u65e5\u672c\u548c\u4e2d\u56fd\u3002\u7ee72015\u5e7410\u6708\uff0c\u6b27\u72c4\u6c83&reg;\uff08\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u8054\u5408\u9038\u6c83&reg;\uff08\u4f0a\u5339\u6728\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u9996\u6b21\u83b7\u5f97\u76d1\u7ba1\u673a\u6784\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u540e\uff0c\u76ee\u524d\u8be5\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5df2\u5728\u8d85\u8fc750\u4e2a\u56fd\u5bb6\u6216\u5730\u533a\u83b7\u5f97\u6279\u51c6\uff0c\u5305\u62ec\u7f8e\u56fd\u3001\u6b27\u76df\u548c\u4e2d\u56fd\u3002&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2022041208440067326\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-67326","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/67326","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=67326"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/67326\/revisions"}],"predecessor-version":[{"id":67327,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/67326\/revisions\/67327"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=67326"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=67326"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=67326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}