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id=\"spanHghltb462\">\u3002\u201d<\/span><\/p>\n<p><b>\u4fe1\u8fbe\u751f\u7269\u9ad8\u7ea7\u526f\u603b\u88c1\u5468\u8f89\u535a\u58eb<\/b>\u8868\u793a\uff1a\u201cIBI322\u662f\u7279\u5f02\u6027\u9488\u5bf9\u91cd\u7ec4\u6297\u5206\u5316\u6297\u539f\u7c0747\uff08CD47\uff09\u548c\u6297\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u4f531\uff08PD-L1\uff09\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u4fe1\u8fbe\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u5e76\u62e5\u6709\u5168\u7403\u6743\u76ca\u3002\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u5728Ia\u671f\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230IBI322\u5728\u6807\u51c6\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671f\u6076\u6027\u80bf\u7624\u60a3\u8005\u4e2d\u521d\u6b65\u7684\u7597\u6548\u4fe1\u53f7\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u63a8\u8fdbIb\u671f\u6269\u5c55\u961f\u5217\u7814\u7a76\uff0c\u8fdb\u4e00\u6b65\u63a2\u7d22IBI322\u5728\u591a\u4e2a\u9002\u5e94\u75c7\u7684\u5b89\u5168\u6027\u4e0e\u7597\u6548\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u901a\u8fc7\u5e03\u5c40\u5b8c\u6574\u3001\u8fdb\u5ea6\u9886\u5148\u7684\u4e0b\u4e00\u4ee3\u80bf\u7624\u514d\u75ab\u6291\u5236\u5242\u9776\u70b9\u7684\u7ba1\u7ebf\u7ec4\u5408\uff0c\u80fd\u7ed9\u66f4\u591a\u60a3\u8005\u5e26\u6765\u4e34\u5e8a\u83b7\u76ca\u3002\u201d<\/p>\n<p><b>\u5173\u4e8e<\/b><b>IBI322<\/b><\/p>\n<p>IBI322\u662f\u7531\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u81ea\u4e3b\u5f00\u53d1\u7684\u7279\u5f02\u6027\u9488\u5bf9CD47\/PD-L1\u9776\u70b9\u7684\u91cd\u7ec4\u53cc\u7279\u5f02\u6027\u6297\u4f53\u3002\u672c\u5019\u9009\u4ea7\u54c1\u53ef\u9776\u5411\u80bf\u7624\u7ec6\u80de\u8868\u9762CD47\uff0c\u963b\u65adSIRP\u03b1\/CD47\u4fe1\u53f7\u901a\u8def\uff0c\u6fc0\u6d3b\u5de8\u566c\u7ec6\u80de\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u541e\u566c\u4f5c\u7528\uff1b\u8fd8\u80fd\u7ed3\u5408\u80bf\u7624\u7ec6\u80de\u8868\u9762PD-L1\uff0c\u963b\u65adPD-1\/PD-L1\u4fe1\u53f7\u901a\u8def\uff0c\u89e3\u9664\u80bf\u7624\u5fae\u73af\u5883\u5bf9T\u7ec6\u80de\u6291\u5236\uff0c\u6fc0\u6d3bT\u7ec6\u80de\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528\u3002IBI322\u901a\u8fc7\u540c\u65f6\u4f5c\u7528\u4e24\u4e2a\u514d\u75ab\u68c0\u67e5\u70b9\uff08CD47\u4e0ePD-L1\uff09\u7684\u53cc\u7279\u5f02\u529f\u80fd\uff0c\u540c\u65f6\u6fc0\u6d3b\u5929\u7136\u514d\u75ab\u548c\u83b7\u5f97\u6027\u514d\u75ab\u901a\u8def\uff0c\u589e\u5f3a\u514d\u75ab\u7cfb\u7edf\u5bf9\u80bf\u7624\u7684\u5b9a\u5411\u8bc6\u522b\uff0c\u5177\u6709\u6297\u80bf\u7624\u7684\u201c\u534f\u540c\u6548\u5e94\u201d\u3002\u6b64\u5916\uff0cIBI322\u901a\u8fc7PD-L1\u6297\u4f53\u6bb5\u7684\u9776\u5411\u4f5c\u7528\uff0c\u63d0\u9ad8\u4e86\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u9009\u62e9\u6027\u7ed3\u5408\u80fd\u529b\uff0c\u51cf\u5c11\u4e0e\u8868\u8fbeCD47\u7684\u4eba\u4f53\u6b63\u5e38\u7ec4\u7ec7\u7ec6\u80de\u7ed3\u5408\uff0c\u964d\u4f4eCD47\u6cbb\u7597\u6027\u6297\u4f53\u5e26\u6765\u7684\u6bd2\u526f\u4f5c\u7528\u3002IBI322\u5df2\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u548c\u7f8e\u56fdFDA\u7684IND\u6279\u51c6\uff0c\u6b63\u5728\u5168\u7403\u79ef\u6781\u5f00\u5c55\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p><b>\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n<p>\u201c\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c\u201d\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u7406\u60f3\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u75be\u75c5\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u30022018\u5e7410\u670831\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a01801\u3002<\/p>\n<p>\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u516c\u53f8\u51ed\u501f\u521b\u65b0\u6210\u679c\u548c\u56fd\u9645\u5316\u7684\u8fd0\u8425\u6a21\u5f0f\u5728\u4f17\u591a\u751f\u7269\u5236\u836f\u516c\u53f8\u4e2d\u8131\u9896\u800c\u51fa\u3002\u5efa\u7acb\u8d77\u4e86\u4e00\u6761\u5305\u62ec32\u4e2a\u65b0\u836f\u54c1\u79cd\u7684\u4ea7\u54c1\u94fe\uff0c\u8986\u76d6\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u591a\u4e2a\u75be\u75c5\u9886\u57df\uff0c\u5176\u4e2d7\u4e2a\u54c1\u79cd\u5165\u9009\u56fd\u5bb6\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u4e13\u9879\u3002\u516c\u53f8\u5df2\u67097\u4e2a\u4ea7\u54c1\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aTYVYT<sup>&reg;<\/sup>\uff1b\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u6538\u540c<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aBYVASDA<sup>&reg;<\/sup>\uff1b\u963f\u8fbe\u6728\u5355\u6297\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