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\u8fbe\u4f2f\u5766®<\/sup>\u7531Incyte\u548c\u4fe1\u8fbe\u751f\u7269\u5171\u540c\u5f00\u53d1\uff0c\u4fe1\u8fbe\u751f\u7269\u8d1f\u8d23\u4e2d\u56fd\u5927\u9646\u3001\u9999\u6e2f\u3001\u6fb3\u95e8\u548c\u53f0\u6e7e\u5730\u533a\u7684\u5546\u4e1a\u5316\u3002\u672c\u6b21\u4e2d\u56fd\u5927\u9646\u5e02\u573a\u83b7\u6279\u662f\u7ee72021\u5e746\u6708\u4e2d\u56fd\u53f0\u6e7e\u83b7\u6279\u30012022\u5e741\u6708\u4e2d\u56fd\u9999\u6e2f\u83b7\u6279\u540e\u7684\u53c8\u4e00\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u8fbe\u4f2f\u5766®<\/sup>\u4e5f\u662f\u9996\u4e2a\u5728\u4e2d\u56fd\u83b7\u6279\u7684\u9009\u62e9\u6027FGFR\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u3002<\/p>\n

\u8be5\u9002\u5e94\u75c7\u7684\u83b7\u6279\u4e3b\u8981\u57fa\u4e8e\u4e24\u9879\u4e34\u5e8a\u7814\u7a76\u3002\u4e00\u9879\u4e3a\u5728\u6d77\u5916\u65e2\u5f80\u7ecf\u8fc7\u81f3\u5c11\u4e00\u7ebf\u7cfb\u7edf\u6027\u6cbb\u7597\u5931\u8d25\u7684\u3001\u4f34FGFR2\u878d\u5408\u6216\u91cd\u6392\u7684\u3001\u624b\u672f\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u80c6\u7ba1\u764c\u53d7\u8bd5\u8005\u4e2d\u8bc4\u4ef7\u4f69\u7c73\u66ff\u5c3c\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684II\u671f\u3001\u5f00\u653e\u6027\u3001\u5355\u81c2\u3001\u591a\u4e2d\u5fc3\u7684\u7814\u7a76\uff08FIGHT202\u7814\u7a76\uff0cNCT02924376\uff09\u3002\u53e6\u4e00\u9879\u662f\u5728\u4e2d\u56fd\u8fdb\u884c\u7684\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6027\u3001\u5355\u81c2\u8bd5\u9a8c\uff08\u7814\u7a76\u4ee3\u53f7\uff1aCIBI375A201, NCT04256980\uff09\uff0c\u76ee\u7684\u4e3a\u8bc4\u4ef7\u4f69\u7c73\u66ff\u5c3c\u5728\u4e2d\u56fd\u540c\u7c7b\u80c6\u7ba1\u764c\u53d7\u8bd5\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u4e24\u9879\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u90fd\u662f\u57fa\u4e8e\u72ec\u7acb\u5f71\u50cf\u59d4\u5458\u4f1a\uff08IRRC\uff09\u6839\u636e\u5b9e\u4f53\u7624\u8bc4\u4ef7\u6807\u51c6V1.1\u8bc4\u4ef7\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u3002<\/p>\n

FIGHT-202\u7814\u7a76[1]\u4e2d\uff0c\u622a\u6b622020\u5e744\u67087\u65e5\u5171\u5165\u7ec4108\u4f8b\u4f34\u6709FGFR2\u91cd\u6392\u6216\u878d\u5408\u7684\u80c6\u7ba1\u764c\u53d7\u8bd5\u8005\uff0c\u63a5\u53d7\u4f69\u7c73\u66ff\u5c3c\u6cbb\u7597\uff0813.5mg\/\u5929\uff0c\u670d\u836f\u4e24\u5468\u505c\u836f\u4e00\u5468\uff09\uff0c\u7531IRRC\u8bc4\u4f30\u7684\u7ecf\u5f71\u50cf\u5b66\u786e\u8ba4\u7684ORR\u4e3a37.0% (95% CI: 27.94%, 46.86%)\uff0c\u5305\u62ec4\u4f8b\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u7684\u53d7\u8bd5\u8005\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DOR\uff09\u4e3a8.08\u4e2a\u6708\uff0c\u5176\u4e2d40\u4f8b\u51fa\u73b0\u80bf\u7624\u7f13\u89e3\u7684\u53d7\u8bd5\u8005\u4e2d\u670926\u4f8b\uff0866%\uff09\u53d7\u8bd5\u8005\u7684\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u5927\u4e8e\u7b49\u4e8e6\u4e2a\u6708\uff0c15\u4f8b\uff0837.5%\uff09\u53d7\u8bd5\u8005\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u5927\u4e8e12\u4e2a\u6708\u3002CIBI375A201\u7814\u7a76\u4e2d\uff0c\u622a\u6b622021\u5e741\u670829\u65e5\uff0c30\u4f8b\u7597\u6548\u53ef\u8bc4\u4ef7\u53d7\u8bd5\u8005\u4e2d\u7684\u5ba2\u89c2\u7f13\u89e3\u7387ORR\u4e3a50%\uff0895% CI: 31.3%,68.7%\uff09\uff0c\u5747\u4e3a\u90e8\u5206\u7f13\u89e3\u3002FIGHT-202\u7814\u7a76\u548cCIBI375A201\u7814\u7a76\u4e2d\u53d7\u8bd5\u8005\u603b\u4f53\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u6bd4\u4f8b\u548c\u7c7b\u522b\u57fa\u672c\u4e00\u81f4\uff0c\u7edd\u5927\u591a\u6570\u4e0d\u826f\u53cd\u5e94\u4e3a1-2\u7ea7\uff0c\u6574\u4f53\u5b89\u5168\u6027\u826f\u597d\u3002<\/p>\n

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\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u770b\u5230\u8fbe\u4f2f\u5766®<\/sup>\uff08\u4f69\u7c73\u66ff\u5c3c\uff09\u901a\u8fc7\u4e86\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7684\u6279\u51c6\u7528\u4e8e\u80c6\u7ba1\u764c\u7684\u4e8c\u7ebf\u6cbb\u7597\uff0c\u8fd9\u662f\u672c\u4ea7\u54c1\u5f00\u53d1\u7684\u53c8\u4e00\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u540c\u65f6\u4e5f\u4e3a\u4e2d\u56fd\u80c6\u7ba1\u764c\u60a3\u8005\u63d0\u4f9b\u4e86\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u201d\uff0c<\/span>\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\u603b\u88c1\u5218\u52c7\u519b\u535a\u58eb<\/b>\u5f3a\u8c03\u8bf4\uff0c\u201c\u8fbe\u4f2f\u5766®<\/sup>\u5728\u65e2\u5f80\u7ecf\u8fc7\u81f3\u5c11\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u5931\u8d25\u7684\u5b58\u5728FGFR2\u878d\u5408\u7684\u665a\u671f\u80c6\u7ba1\u764c\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u5c55\u793a\u51fa\u4e86\u4ee4\u4eba\u6ee1\u610f\u7684\u5b89\u5168\u6027\u53ca\u7597\u6548\uff0c\u8fdb\u4e00\u6b65\u589e\u5f3a\u4e86\u6211\u4eec\u6df1\u5165\u63a2\u7d22\u548c\u62d3\u5bbd\u4ea7\u54c1\u94fe\u7684\u4fe1\u5fc3\u3002\u76ee\u524d\u8fbe\u4f2f\u5766®<\/sup>\u7528\u4e8e\u665a\u671f\u4e00\u7ebf\u80c6\u7ba1\u764c\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u5305\u62ec\u4e2d\u56fd\u5728\u5185\u7684\u5168\u7403\u8303\u56f4\u5f00\u5c55\uff0c\u672a\u6765\u6211\u4eec\u8fd8\u5c06\u56f4\u7ed5\u8fbe\u4f2f\u5766®<\/sup>\u8fdb\u884c\u6df1\u5ea6\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u79ef\u6781\u63a2\u7d22\u5176\u4ed6\u9002\u5e94\u75c7\uff0c\u6211\u4eec\u76f8\u4fe1\u5c06\u4e3a\u66f4\u591a\u7684\u764c\u75c7\u60a3\u8005\u5c06\u5e26\u6765\u4e34\u5e8a\u83b7\u76ca\u3002\u201d<\/p>\n

\u5173\u4e8e\u665a\u671f\u80c6\u7ba1\u764c\u548c<\/b>FGFR2<\/b>\u57fa\u56e0\u878d\u5408<\/b>\/<\/b>\u91cd\u6392<\/b><\/p>\n

\u80c6\u7ba1\u764c\u662f\u4e00\u79cd\u8d77\u6e90\u4e8e\u80c6\u7ba1\u4e0a\u76ae\u7ec6\u80de\u7684\u6076\u6027\u80bf\u7624\uff0c\u6309\u6240\u53d1\u751f\u7684\u90e8\u4f4d\u53ef\u5206\u4e3a\u809d\u5185\u80c6\u7ba1\u764c\u548c\u809d\u5916\u80c6\u7ba1\u764c\u4e24\u5927\u7c7b\u3002\u8fd1\u5e74\u6765\u80c6\u7ba1\u764c\u7684\u53d1\u75c5\u7387\u9010\u5e74\u5347\u9ad8\uff0c\u624b\u672f\u662f\u552f\u4e00\u5177\u6709\u6cbb\u6108\u6f5c\u529b\u7684\u6cbb\u7597\u65b9\u5f0f\u3002\u4f46\u662f\u5927\u90e8\u5206\u80c6\u7ba1\u764c\u60a3\u8005\u5728\u521d\u8bca\u65f6\u5373\u4e3a\u4e0d\u53ef\u5207\u9664\u6027\u80bf\u7624\u6216\u5b58\u5728\u8f6c\u79fb\uff0c\u5931\u53bb\u4e86\u624b\u672f\u6839\u6cbb\u7684\u673a\u4f1a\u3002\u5bf9\u4e8e\u4e0d\u53ef\u5207\u9664\u3001\u5b58\u5728\u8f6c\u79fb\u7684\u6216\u624b\u672f\u540e\u590d\u53d1\u7684\u80c6\u7ba1\u764c\u60a3\u8005\uff0c\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u4e3a\u987a\u94c2\u8054\u5408\u5409\u897f\u4ed6\u6ee8\uff0c\u5176\u7597\u6548\u5dee\u5f3a\u4eba\u610f\uff0c\u603b\u751f\u5b58\u671f\u5c0f\u4e8e1\u5e74\u3002<\/p>\n

FGFR\u57fa\u56e0\u53d8\u5f02\u5b58\u5728\u4e8e\u591a\u79cd\u7c7b\u578b\u7684\u4eba\u7c7b\u80bf\u7624\u4e2d\uff0c\u4e3b\u8981\u901a\u8fc7FGFR\u57fa\u56e0\u6269\u589e\u3001\u7a81\u53d8\u3001\u67d3\u8272\u4f53\u6613\u4f4d\u4ee5\u53ca\u914d\u4f53\u4f9d\u8d56\u6027\u6d3b\u5316\u5f15\u8d77\u7684FGFR\u4fe1\u53f7\u5f02\u5e38\u3002\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u4fe1\u53f7\u901a\u8fc7\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u3001\u5b58\u6d3b\u3001\u8fc1\u79fb\u548c\u8840\u7ba1\u751f\u6210\u6765\u4fc3\u8fdb\u6076\u6027\u80bf\u7624\u7684\u53d1\u5c55\u3002\u5305\u62ec\u8fbe\u4f2f\u5766®<\/sup>\u5185\u7684\u9009\u62e9\u6027FGFR\u6291\u5236\u5242\u7684\u65e9\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u8be5\u7c7b\u836f\u7269\u5177\u6709\u53ef\u8010\u53d7\u7684\u5b89\u5168\u6027\uff0c\u5728\u5b58\u5728FGF\/FGFR\u53d8\u5f02\u53d7\u8bd5\u8005\u4e2d\u5177\u6709\u4e34\u5e8a\u83b7\u76ca\u7684\u521d\u6b65\u8ff9\u8c61\u3002<\/p>\n

\u5173\u4e8e<\/b>\u8fbe\u4f2f\u5766<\/b>®<\/b><\/sup>\uff08\u4f69\u7c73\u66ff\u5c3c\u7247\uff0c<\/b>pemigatinib<\/b>\uff09<\/b><\/p>\n

Pemigatinib\u662f\u4e00\u79cd\u9488\u5bf9FGFR\u4e9a\u578b1\/2\/3\u7684\u5f3a\u6548\u9009\u62e9\u6027\u53e3\u670d\u6291\u5236\u5242\u30022020\u5e744\u6708\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6Incyte\u516c\u53f8Pemazyre®<\/sup>\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u6210\u4eba\u665a\u671f\/\u8f6c\u79fb\u6027\u6216\u4e0d\u53ef\u5207\u9664\u7684FGFR2\u57fa\u56e0\u878d\u5408\/\u91cd\u6392\u578b\u80c6\u7ba1\u764c\uff08\u901a\u8fc7FDA\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u786e\u8ba4\uff09\u3002<\/p>\n

\u5728\u65e5\u672c\uff0cPemazyre®<\/sup>\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u5177\u6709FGFR2\u878d\u5408\u57fa\u56e0\u7684\u4e0d\u53ef\u5207\u9664\u7684\u80c6\u9053\u764c\uff08BTC\uff09\u5e76\u5728\u5316\u7597\u540e\u6076\u5316\u7684\u60a3\u8005\u3002\u5728\u6b27\u6d32\uff0cPemazyre®<\/sup>\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597FGFR2\u878d\u5408\u6216\u91cd\u6392\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c6\u7ba1\u764c\u5e76\u5df2\u5728\u81f3\u5c11\u4e00\u9879\u5148\u524d\u7684\u5168\u8eab\u6027\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u6210\u4eba\u60a3\u8005\u3002Pemazyre®<\/sup>\u7531Incyte\u5728\u7f8e\u56fd\uff0c\u6b27\u6d32\u548c\u65e5\u672c\u9500\u552e\u3002<\/p>\n

2018\u5e7412\u6708\uff0c\u4fe1\u8fbe\u751f\u7269\u4e0eIncyte\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u4fe1\u8fbe\u751f\u7269\u62e5\u6709pemigatinib\u5728\u4e2d\u56fd\u5927\u9646\u3001\u9999\u6e2f\u3001\u6fb3\u95e8\u548c\u53f0\u6e7e\u5730\u533a\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u5229\u3002<\/p>\n

2020\u5e743\u6708\uff0c\u4fe1\u8fbe\u751f\u7269\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u4e00\u9879\u9488\u5bf9\u665a\u671f\u80c6\u7ba1\u764c\u60a3\u8005\u7684\u5173\u952e\u6027\u8bd5\u9a8c\u5df2\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002<\/p>\n

2021\u5e746\u6708\u8fbe\u4f2f\u5766®<\/sup>\uff08\u4f69\u7c73\u66ff\u5c3c\u7247\uff09\u88ab\u53f0\u6e7e\u536b\u751f\u798f\u5229\u90e8\u98df\u54c1\u836f\u7269\u7ba1\u7406\u7f72\uff08TFDA\uff09\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u63a5\u53d7\u8fc7\u5168\u8eab\u6027\u836f\u7269\u6cbb\u7597\u3001\u80bf\u7624\u5177\u6709\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f532\uff08FGFR2\uff09\u878d\u5408\u6216\u91cd\u6392\u3001\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c6\u7ba1\u764c\u3002<\/p>\n

2022\u5e741\u6708\uff0c\u8fbe\u4f2f\u5766®<\/sup>\uff08\u4f69\u7c73\u66ff\u5c3c\u7247\uff09\u88ab\u9999\u6e2f\u7279\u522b\u884c\u653f\u533a\u653f\u5e9c\u536b\u751f\u7f72\uff08DH\uff09\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6027\u836f\u7269\u6cbb\u7597\u3001\u4f34\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f532\uff08FGFR2\uff09\u878d\u5408\u6216\u91cd\u6392\u3001\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c6\u7ba1\u764c\u3002<\/p>\n

2022\u5e744\u6708\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6b63\u5f0f\u6279\u51c6\u8fbe\u4f2f\u5766®<\/sup>\uff08\u4f69\u7c73\u66ff\u5c3c\u7247\uff09\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u7cfb\u7edf\u6027\u6cbb\u7597\uff0c\u4e14\u7ecf\u68c0\u6d4b\u786e\u8ba4\u5b58\u5728\u6709FGFR2\u878d\u5408\u6216\u91cd\u6392\u7684\u665a\u671f\u3001\u8f6c\u79fb\u6027\u6216\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u80c6\u7ba1\u764c\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/p>\n

Pemazyre®<\/sup>\u662fIncyte Corporation\u7684\u5546\u6807\u3002 <\/p>\n

\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n

\u201c\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c\u201d\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u7406\u60f3\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u75be\u75c5\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u30022018\u5e7410\u670831\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a01801\u3002<\/p>\n

\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u516c\u53f8\u51ed\u501f\u521b\u65b0\u6210\u679c\u548c\u56fd\u9645\u5316\u7684\u8fd0\u8425\u6a21\u5f0f\u5728\u4f17\u591a\u751f\u7269\u5236\u836f\u516c\u53f8\u4e2d\u8131\u9896\u800c\u51fa\u3002\u5efa\u7acb\u8d77\u4e86\u4e00\u6761\u5305\u62ec32\u4e2a\u65b0\u836f\u54c1\u79cd\u7684\u4ea7\u54c1\u94fe\uff0c\u8986\u76d6\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u591a\u4e2a\u75be\u75c5\u9886\u57df\uff0c\u5176\u4e2d7\u4e2a\u54c1\u79cd\u5165\u9009\u56fd\u5bb6"\u91cd\u5927\u65b0\u836f\u521b\u5236"\u4e13\u9879\u3002\u516c\u53f8\u5df2\u67097\u4e2a\u4ea7\u54c1\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u8212®<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aTYVYT®<\/sup>\uff1b\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u6538\u540c®<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aBYVASDA®<\/sup>\uff1b\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u82cf\u7acb\u4fe1®<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aSULINNO®<\/sup>\uff1b\u5229\u59a5\u6614\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u534e®<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aHALPRYZA®<\/sup>\uff1b\u4f69<\/span>\u7c73\u66ff\u5c3c\u7247\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u5766®<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aPEMAZYRE®<\/sup>\uff1b\u5965\u96f7\u5df4\u66ff\u5c3c\u7247\uff0c\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b®<\/sup>; \u96f7\u83ab\u897f\u5c24\u5355\u6297\uff0c\u5546\u54c1\u540d\uff1a\u5e0c\u5189\u62e9®<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aCYRAMZA®<\/sup>\uff09\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c 1\u4e2a\u54c1\u79cd\u5728NMPA\u5ba1\u8bc4\u4e2d\uff0c\u53e6\u5916\u8fd8\u670919\u4e2a\u4ea7\u54c1\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n

\u4fe1\u8fbe\u751f\u7269\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u5177\u6709\u56fd\u9645\u5148\u8fdb\u6c34\u5e73\u7684\u9ad8\u7aef\u751f\u7269\u836f\u5f00\u53d1\u3001\u4ea7\u4e1a\u5316\u4eba\u624d\u56e2\u961f\uff0c\u5305\u62ec\u4f17\u591a\u6d77\u5f52\u4e13\u5bb6\uff0c\u5e76\u4e0e\u7f8e\u56fd\u793c\u6765\u5236\u836f\u3001Adimab\u3001Incyte\u3001MD Anderson \u764c\u75c7\u4e2d\u5fc3\u548c\u97e9\u56fdHanmi\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1awww.innoventbio.com<\/a> \u6216\u516c\u53f8\u9886\u82f1\u8d26\u53f7www.linkedin.com\/company\/innovent-biologics\/<\/a>\u3002<\/p>\n

\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n

\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528"\u9884\u671f"\u3001"\u76f8\u4fe1"\u3001"\u9884\u6d4b"\u3001"\u671f\u671b"\u3001"\u6253\u7b97"\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u5e76\u65e0\u4e49\u52a1\u4e0d\u65ad\u5730\u66f4\u65b0\u8fd9\u4e9b\u9884\u6d4b\u6027\u9648\u8ff0\u3002<\/p>\n

\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n

\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u96c7\u5458\u4ee3\u7406\u6982\u4e0d\u627f\u62c5 (a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7f51\u7ad9\u6240\u8f7d\u524d\u77bb\u6027\u8868\u8ff0\u4e4b\u4efb\u4f55\u4e49\u52a1;\u53ca (b) \u5018\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5b9e\u73b0\u6216\u53d8\u6210\u4e0d\u6b63\u786e\u800c\u5f15\u81f4\u4e4b\u4efb\u4f55\u8d23\u4efb\u3002<\/p>\n

\n\n\n\n
\n

[1] \u5173\u4e8e FIGHT-202\u7684\u8bd5\u9a8c\u53ca\u7ed3\u679c\u8be6\u60c5, \u8bf7\u89c1\u5982\u4e0b\u94fe\u63a5\uff1a https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02924376<\/a><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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