{"id":66889,"date":"2022-04-06T16:00:00","date_gmt":"2022-04-06T09:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022040616000066889"},"modified":"2022-04-06T18:13:55","modified_gmt":"2022-04-06T10:13:55","slug":"%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9e%e5%ae%a3%e5%b8%83%e6%ac%a7%e6%b4%b2%e8%8d%af%e5%93%81%e7%ae%a1%e7%90%86%e5%b1%80%e5%b7%b2%e5%8f%97%e7%90%86%e7%99%be%e6%b3%bd%e5%ae%89r%e7%94%a8%e4%ba%8e","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022040616000066889","title":{"rendered":"\u767e\u6d4e\u795e\u5dde\u5ba3\u5e03\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\u5df2\u53d7\u7406\u767e\u6cfd\u5b89(R)\u7528\u4e8e\u6cbb\u7597\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7"},"content":{"rendered":"<p><p>&nbsp;<\/p>\n<p><i>\u8fd9\u662f\u767e\u6cfd\u5b89<\/i><i><sup>&reg;<\/sup><\/i><i>\u5728\u6b27\u6d32\u7684\u9996\u6b21\u7533\u62a5\uff0c\u4e5f\u662f\u8bfa\u534e\u7ee7\u83b7\u5f97\u8be5\u4ea7\u54c1\u5728\u5317\u7f8e\u3001\u6b27\u6d32\u548c\u65e5\u672c\u5408\u4f5c\u6388\u6743\u540e\u5728\u6b27\u6d32\u7684\u9996\u6b21\u7533\u62a5<\/i>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"legendSpanClass\">\u4e2d\u56fd\u5317\u4eac\u3001\u745e\u58eb\u5df4\u585e\u5c14\u548c\u7f8e\u56fd\u9ebb\u7701\u5251\u6865<\/span><span class=\"legendSpanClass\">2022\u5e744\u67086\u65e5<\/span> &nbsp;\/\u7f8e\u901a\u793e\/ &#8212; <a href=\"https:\/\/www.beigene.com\/\" target=\"_blank\" rel=\"nofollow noopener\">\u767e\u6d4e\u795e\u5dde<\/a>\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff1b\u4e0a\u4ea4\u6240\u4ee3\u7801\uff1a688235\uff09\u662f\u4e00\u5bb6\u7acb\u8db3\u4e8e\u79d1\u5b66\u7684\u5168\u7403\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u521b\u65b0\u3001\u53ef\u8d1f\u62c5\u7684\u836f\u7269\uff0c\u65e8\u5728\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u6548\u679c\uff0c\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u516c\u53f8\u4e8e\u4eca\u65e5\u5ba3\u5e03\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u5168\u8eab\u5316\u7597\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\uff08ESCC\uff09\u60a3\u8005\uff0c\u4ee5\u53ca\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\uff08MAA\uff09\u5df2\u83b7\u5f97\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u53d7\u7406\uff0c\u76ee\u524d\u6b63\u5728\u5ba1\u8bc4\u4e2d\u3002\u8be5\u7533\u8bf7\u7531\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u6b27\u6d32\u8bb8\u53ef\u6301\u6709\u4eba\u8bfa\u534e\u63d0\u4ea4\u3002\u5176\u4e2d\uff0c\u9488\u5bf9NSCLC\u9012\u4ea4\u7684\u76f8\u5173\u9002\u5e94\u75c7\u5305\u62ec\uff1a&nbsp;<\/p>\n<ul type=\"disc\">\n<li>\u5355\u836f\u6cbb\u7597\u65e2\u5f80\u7ecf\u5316\u7597\u540e\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u7684\u6210\u4eba\u60a3\u8005\uff1b<\/li>\n<li>\u4f5c\u4e3a\u4e00\u7ebf\u7597\u6cd5\uff0c\u4e0e\u5361\u94c2\u548c\u7d2b\u6749\u9187\uff08\u6216\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\uff09\u8054\u5408\u7528\u836f\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6NSCLC\u6210\u4eba\u60a3\u8005\uff1b<\/li>\n<li>\u4f5c\u4e3a\u4e00\u7ebf\u7597\u6cd5\uff0c\u4e0e\u57f9\u7f8e\u66f2\u585e\u548c\u542b\u94c2\u5316\u7597\u65b9\u6848\u8054\u5408\u7528\u836f\u6cbb\u7597\u65e0EGFR\u6216ALK\u9633\u6027\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6NSCLC\u6210\u4eba\u60a3\u8005\u3002&nbsp;<\/li>\n<\/ul>\n<p>\u767e\u6d4e\u795e\u5dde\u9ad8\u7ea7\u526f\u603b\u88c1\u3001\u5b9e\u4f53\u7624\u9996\u5e2d\u533b\u5b66\u5b98Mark Lanasa\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a&quot;\u6211\u4eec\u5728\u9488\u5bf9\u4e8c\u7ebfESCC\u548cNSCLC\u4e2d\u8fdb\u884c\u7684\u5168\u74033\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\uff0c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5355\u836f\u663e\u8457\u6539\u5584\u4e86\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\uff0c\u5e76\u4e14\u5728\u8fd9\u4e9b\u6cbb\u7597\u7ec4\u4e2d\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\u3002\u5728\u4e24\u9879\u9488\u5bf9\u4e00\u7ebfNSCLC\u76843\u671f\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\uff0c\u76f8\u6bd4\u5316\u7597\uff0c\u65e0\u8bba\u662f\u9cde\u72b6\u7ec4\u7ec7\uff0c\u8fd8\u662f\u975e\u9cde\u72b6\u7ec4\u7ec7\uff0c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u8054\u5408\u5316\u7597\u90fd\u663e\u793a\u51fa\u663e\u8457\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u6539\u5584\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u51fa\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u6b64\u6b21\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5728EMA\u9012\u4ea4\u9996\u6b21\u4e0a\u5e02\u7533\u8bf7\u662f\u6211\u4eec\u4e0e\u8bfa\u534e\u5408\u4f5c\u8fbe\u6210\u7684\u53c8\u4e00\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff0c\u6211\u4eec\u671f\u5f85\u5728\u53cc\u65b9\u5408\u4f5c\u7684\u5730\u533a\u4e2d\uff0c\u5171\u540c\u62d3\u5c55\u8fd9\u4e00\u521b\u65b0\u836f\u7269\u7684\u53ef\u53ca\u6027\u3002\u6211\u4eec\u7684\u56e2\u961f\u6bcf\u5929\u90fd\u5728\u52aa\u529b\u52a0\u5feb\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7684\u8fdb\u5c55\uff0c\u81f4\u529b\u4e8e\u5c06\u8fd9\u4e00\u91cd\u8981\u7684\u514d\u75ab\u6cbb\u7597\u65b0\u9009\u62e9\u5e26\u7ed9\u5168\u7403\u66f4\u591a\u60a3\u8005\u3002&quot;&nbsp;<\/p>\n<p>\u6b64\u6b21\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7528\u4e8eNSCLC\u7684MAA\u9012\u4ea4\u662f\u57fa\u4e8e\u767e\u6d4e\u795e\u5dde\u76843\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT03358875\u3001NCT03594747\u3001NCT03663205\uff09\u7684\u7ed3\u679c\uff0c\u8fd9\u4e09\u9879\u8bd5\u9a8c\u5171\u7eb3\u5165\u4e861499\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec\u4e00\u9879RATIONALE 303\u8bd5\u9a8c\u3002\u8fd9\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6027\u3001\u5168\u74033\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u5bf9\u6bd4\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u548c\u591a\u897f\u4ed6\u8d5b\u7528\u4e8e\u9488\u5bf9\u65e2\u5f80\u7ecf\u542b\u94c2\u5316\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u4e8c\u7ebf\u6216\u4e09\u7ebf\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u3002\u8be5\u8bd5\u9a8c\u5728\u7f8e\u6d32\u3001\u6b27\u6d32\u3001\u4e9a\u6d32\u548c\u5927\u6d0b\u6d32\u768410\u4e2a\u56fd\u5bb6\u5171\u5165\u7ec4\u4e86805\u4f8b\u60a3\u8005\uff0c\u60a3\u8005\u4ee52:1\u7684\u6bd4\u4f8b\u968f\u673a\u5206\u914d\u81f3\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7ec4\u6216\u591a\u897f\u4ed6\u8d5b\u7ec4\u3002\u767e\u6d4e\u795e\u5dde\u5df2\u4e8e2020\u5e7411\u6708<span id=\"spanHghlt4371\">\u5ba3\u5e03<\/span>\uff0c\u7ecf\u72ec\u7acb\u6570\u636e\u76d1\u67e5\u59d4\u5458\u4f1a\uff08IDMC\uff09\u8bc4\u4f30\u5224\u65ad\uff0c\u8be5\u8bd5\u9a8c\u5728\u8ba1\u5212\u7684\u671f\u4e2d\u5206\u6790\u4e2d\u8fbe\u5230\u4e86\u603b\u751f\u5b58\u671f\uff08OS\uff09\u8fd9\u4e00\u4e3b\u8981\u7ec8\u70b9\u3002\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7684\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u5728\u5404\u80bf\u7624\u7c7b\u578b\u4e2d\u65e2\u5f80\u62a5\u544a\u7684\u5df2\u77e5\u98ce\u9669\u4e00\u81f4\uff0c\u672a\u51fa\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u767e\u6d4e\u795e\u5dde\u4e8e2021\u5e744\u6708\u5728\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u8be5\u8bd5\u9a8c\u7684\u671f\u4e2d\u5206\u6790\u7ed3\u679c\u3002&nbsp;<\/p>\n<p>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7528\u4e8eESCC\u7684MAA\u9012\u4ea4\u662f\u57fa\u4e8e\u767e\u6d4e\u795e\u5ddeRATIONALE 302\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u8fd9\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6027\u3001\u591a\u4e2d\u5fc3\u7684\u5168\u74033\u671f\u8bd5\u9a8c\uff08NCT03430843\uff09\uff0c\u65e8\u5728\u8bc4\u4ef7\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u76f8\u6bd4\u7814\u7a76\u8005\u9009\u62e9\u7684\u5316\u7597\u65b9\u6848\u7528\u4e8e\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u4e8c\u7ebf\u6cbb\u7597\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8be5\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u5df2\u57282021\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\uff08ASCO 2021\uff09\u4e0a<span id=\"spanHghlt4224\">\u516c\u5e03<\/span>\u3002\u9012\u4ea4\u8d44\u6599\u4e2d\u8fd8\u5305\u62ec\u57287\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d1972\u4f8b\u63a5\u53d7\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5355\u836f\u6cbb\u7597\u60a3\u8005\u7684\u5b89\u5168\u6027\u6570\u636e\u3002\u6b64\u5916\uff0c\u7f8e\u56fdFDA\u76ee\u524d\u6b63\u5728\u5ba1\u8bc4\u8be5\u9002\u5e94\u75c7\u7684\u65b0\u836f\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\uff08BLA\uff09\u3002\u9664\u6b27\u76df\u548c\u7f8e\u56fd\u5916\uff0c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7528\u4e8eESCC\u60a3\u8005\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u4e5f\u5728\u4e2d\u56fd\u83b7\u5f97\u53d7\u7406\u4e14\u6b63\u5728\u5ba1\u8bc4\u4e2d\u3002&nbsp;<\/p>\n<p><b>\u5173\u4e8e\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\uff08<\/b><b>ESCC<\/b><b>\uff09<\/b>&nbsp;<\/p>\n<p>&nbsp;\u5728\u5168\u7403\u8303\u56f4\u5185\uff0c\u98df\u7ba1\u764c\u662f\u6700\u5e38\u89c1\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\uff0c\u4e5f\u662f\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002<sup>\u2170<\/sup>2020\u5e74\uff0c\u98df\u7ba1\u764c\u7684\u53d1\u75c5\u7387\u5728\u6240\u6709\u764c\u75c7\u53d1\u75c5\u7387\u4e2d\u6392\u540d\u7b2c\u4e03\uff08604,000\u4f8b\u65b0\u53d1\u75c5\u4f8b\uff09\uff0c\u603b\u6b7b\u4ea1\u7387\u6392\u540d\u7b2c\u516d\uff08544,000\u4f8b\u6b7b\u4ea1\u75c5\u4f8b\uff09\uff0c\u8fd9\u8868\u660e\uff0c\u6bcf18\u4f8b\u764c\u75c7\u6b7b\u4ea1\u4e2d\u67091\u4f8b\u662f\u56e0\u98df\u7ba1\u764c\u6b7b\u4ea1\u3002<sup>\u2171<\/sup>&nbsp;<\/p>\n<p>\u6839\u636e\u764c\u7ec6\u80de\u4f4d\u7f6e\u7684\u4e0d\u540c\uff0c\u98df\u7ba1\u764c\u4e3b\u8981\u5206\u4e3a\u4e24\u79cd\u7c7b\u578b\uff1a\u9cde\u72b6\u7ec6\u80de\u764c\uff08ESCC\uff09\u548c\u817a\u764c\uff08EAC\uff09\u3002<sup>\u2172<\/sup>\u7531\u4e8e\u8bb8\u591a\u60a3\u8005\u5728\u786e\u8bca\u65f6\u5df2\u5904\u4e8e\u75be\u75c5\u665a\u671f\uff0cESCC\u60a3\u8005\u7684\u603b\u4f53\u9884\u540e\u8f83\u4e0d\u7406\u60f3\uff0c\u6cbb\u7597\u6781\u5177\u6311\u6218\u6027\u3002<sup>\u2173\uff0c\u2174<\/sup>&nbsp;<\/p>\n<p><b>\u5173\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08<\/b><b>NSCLC<\/b><b>\uff09<\/b>&nbsp;<\/p>\n<p>\u5728\u5168\u7403\uff0c\u80ba\u764c\u662f\u7b2c\u4e8c\u5927\u5e38\u89c1\u7684\u764c\u75c7\u7c7b\u578b\uff0c\u4e5f\u662f\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002<sup>\u2175<\/sup>\u5728\u6b27\u6d32\uff0c\u80ba\u764c\u662f\u7b2c\u4e09\u5927\u5e38\u89c1\u764c\u75c7\u3002\u5728\u6240\u6709\u80ba\u764c\u75c5\u4f8b\u4e2d\uff0cNSCLC\u75c5\u4f8b\u7ea6\u536085 ~ 90%\u3002<sup>\u2176<\/sup>\u57282018\u5e74\uff0c\u6b27\u6d32\u65b0\u8bca\u65ad\u80ba\u764c\u75c5\u4f8b\u6570\u9884\u4f30\u8d85\u8fc747\u4e07\u4f8b\uff08Ferlay et al., 2018\uff09\u3002<sup>\u2177<\/sup>&nbsp;IIIB\u671f\u548cIV\u671fNSCLC\u60a3\u8005\u7ecf\u6cbb\u540e\u7684\u4e94\u5e74\u751f\u5b58\u7387\u5206\u522b\u4ec5\u4e3a5%\u548c2%\u3002<sup>\u2178<\/sup>&nbsp;<\/p>\n<p><b>\u5173\u4e8e\u767e\u6cfd\u5b89<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09<\/b>&nbsp;<\/p>\n<p>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u662f\u4e00\u6b3e\u4eba\u6e90\u5316IgG4\u6297\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f531\uff08PD-1\uff09\u5355\u514b\u9686\u6297\u4f53\uff0c\u8bbe\u8ba1\u76ee\u7684\u65e8\u5728\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u4e0e\u5de8\u566c\u7ec6\u80de\u4e2d\u7684Fc\u03b3\u53d7\u4f53\u7ed3\u5408\u3002\u4e34\u5e8a\u524d\u6570\u636e\u8868\u660e\uff0c\u5de8\u566c\u7ec6\u80de\u4e2d\u7684Fc\u03b3\u53d7\u4f53\u7ed3\u5408\u4e4b\u540e\u4f1a\u6fc0\u6d3b\u6297\u4f53\u4f9d\u8d56\u7ec6\u80de\u4ecb\u5bfc\u6740\u4f24T\u7ec6\u80de\uff0c\u4ece\u800c\u964d\u4f4e\u4e86PD-1\u6297\u4f53\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u662f\u7b2c\u4e00\u6b3e\u7531\u767e\u6d4e\u795e\u5dde\u7684\u514d\u75ab\u80bf\u7624\u751f\u7269\u5e73\u53f0\u7814\u53d1\u7684\u836f\u7269\uff0c\u76ee\u524d\u6b63\u8fdb\u884c\u5355\u836f\u53ca\u8054\u5408\u7597\u6cd5\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u5f00\u53d1\u4e00\u7cfb\u5217\u9488\u5bf9\u5b9e\u4f53\u7624\u548c\u8840\u6db2\u80bf\u7624\u7684\u5e7f\u6cdb\u9002\u5e94\u75c7\u3002&nbsp;<\/p>\n<p>\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u5df2\u6279\u51c6\u767e\u6cfd\u5b89<sup>&reg;<\/sup>7\u9879\u9002\u5e94\u75c7\uff0c\u5305\u62ec\uff1a&nbsp;<\/p>\n<ol type=\"1\">\n<li>\u5b8c\u5168\u6279\u51c6\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u8054\u5408\u5316\u7597\u7528\u4e8e\u665a\u671f\u9cde\u72b6NSCLC\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597<\/li>\n<li>\u5b8c\u5168\u6279\u51c6\u767e\u6cfd\u5b89<sup>&reg;<\/sup><span>\u8054\u5408\u5316\u7597\u7528\u4e8e\u665a\u671f\u975e\u9cde\u72b6NSCLC\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597 <\/span><\/li>\n<li>\u5b8c\u5168\u6279\u51c6\u767e\u6cfd\u5b89<sup>&reg;<\/sup><span>\u9488\u5bf9\u65e2\u5f80\u63a5\u53d7\u94c2\u7c7b\u836f\u7269\u5316\u7597\u540e\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u7684\u4e8c\u7ebf\u6216\u4e09\u7ebf\u6cbb\u7597 <\/span><\/li>\n<li>\u9644\u6761\u4ef6\u6279\u51c6\u767e\u6cfd\u5b89<sup>&reg;<\/sup><span>\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u6cbb\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08cHL\uff09\u60a3\u8005 <\/span><\/li>\n<li>\u9644\u6761\u4ef6\u6279\u51c6\u767e\u6cfd\u5b89<sup>&reg;<\/sup><span>\u7528\u4e8ePD-L1\u9ad8\u8868\u8fbe\u7684\u63a5\u53d7\u542b\u94c2\u5316\u7597\u5931\u8d25\u5305\u62ec\u65b0\u8f85\u52a9\u6216\u8f85\u52a9\u5316\u759712\u4e2a\u6708\u5185\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\uff08UC\uff09\u60a3\u8005 <\/span><\/li>\n<li>\u9644\u6761\u4ef6\u6279\u51c6\u767e\u6cfd\u5b89<sup>&reg;<\/sup><span>\u65e2\u5f80\u81f3\u5c11\u7ecf\u8fc7\u4e00\u79cd\u5168\u8eab\u6cbb\u7597\u7684\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u60a3\u8005 <\/span><\/li>\n<li>\u9644\u6761\u4ef6\u6279\u51c6\u767e\u6cfd\u5b89<sup>&reg;<\/sup><span>\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u578b\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u57fa\u56e0\u7f3a\u9677\u578b\uff08dMMR\uff09\u6210\u4eba\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u3002&nbsp;<\/span><\/li>\n<\/ol>\n<p>\u9488\u5bf9\u4e0a\u8ff0\u9644\u6761\u4ef6\u83b7\u6279\u9002\u5e94\u75c7\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u6b63\u5728\u8fdb\u884c\u7684\u786e\u8bc1\u6027\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u6216\u5176\u4ed6\u7ecf\u536b\u751f\u76d1\u7ba1\u90e8\u95e8\u6279\u51c6\u7684\u786e\u8bc1\u6027\u8bd5\u9a8c\u7ed3\u679c\u3002&nbsp;<\/p>\n<p>\u6b64\u5916\uff0c\u4e24\u9879\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u6b63\u5728\u63a5\u53d7NMPA\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u7684\u5ba1\u8bc4\uff0c\u5305\u62ec\u4e00\u9879\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e00\u7ebf\u6807\u51c6\u5316\u7597\u540e\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\uff08ESCC\uff09\u60a3\u8005\uff0c\u4ee5\u53ca\u4e00\u9879\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\uff08NPC\uff09\u60a3\u8005\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u3002&nbsp;<\/p>\n<p>\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u53d7\u7406\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7ecf\u7cfb\u7edf\u6cbb\u7597\u540e\u4e0d\u53ef\u5207\u9664\u3001\u590d\u53d1\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u3002&nbsp;<\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u5df2\u5728\u4e2d\u56fd\u548c\u5168\u7403\u8303\u56f4\u5185\u5f00\u5c55\u6216\u5b8c\u6210\u4e86\u8d85\u8fc720\u9879\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7684\u6f5c\u5728\u6ce8\u518c\u53ef\u7528\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u4e2d\u5305\u62ec17\u98793\u671f\u4e34\u5e8a\u8bd5\u9a8c\u548c4\u9879\u5173\u952e\u60272\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u6b64\u5916\uff0c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u4e0e\u5176\u4ed6\u836f\u7269\uff08\u5305\u62ec\u6b27\u53f8\u73c0\u5229\u5355\u6297\u3001sitravatinib\u548czanidatamab\uff09\u8054\u5408\u7528\u836f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u6b63\u5728\u8fdb\u884c\u4e2d\u3002&nbsp;<\/p>\n<p>2021\u5e741\u6708\uff0c\u767e\u6d4e\u795e\u5dde\u4e0e\u8bfa\u534e\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u6388\u6743\u8bfa\u534e\u5728\u5317\u7f8e\u3001\u6b27\u6d32\u548c\u65e5\u672c\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u3002&nbsp;<\/p>\n<p>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u4ee5\u5916\u56fd\u5bb6\u6216\u5730\u533a\u5c1a\u672a\u83b7\u6279\u3002&nbsp;<\/p>\n<p><b>\u5173\u4e8e\u767e\u6cfd\u5b89<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u7684\u4e34\u5e8a\u7814\u53d1\u9879\u76ee<\/b>&nbsp;<\/p>\n<p>\u767e\u6cfd\u5b89&reg;\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5305\u62ec\uff1a&nbsp;<\/p>\n<ul type=\"disc\">\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u591a\u897f\u4ed6\u8d5b\u7528\u4e8e\u4e8c\u7ebf\u6216\u4e09\u7ebf\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5b89\u5168\u6027\u6709\u6548\u6027\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03358875\uff09\uff1b&nbsp;<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u6551\u63f4\u6027\u5316\u7597\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04486391\uff09\uff1b<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03967977\uff09\uff1b<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03594747\uff09\uff1b&nbsp;<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03663205\uff09\uff1b<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u542b\u94c2\u53cc\u836f\u5316\u7597\u7528\u4e8e\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04379635\uff09\uff1b<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\/\u5b89\u6170\u5242\u8054\u5408\u94c2\u7c7b\u836f\u7269\u548c\u4f9d\u6258\u6cca\u82f7\u7528\u4e8e\u6cbb\u7597\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04005716\uff09\uff1b<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u809d\u7ec6\u80de\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03412773\uff09\uff1b<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7ecf\u6cbb\u60a3\u8005\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03419897\uff09\uff1b<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u8180\u80f1\u764c\u60a3\u8005\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04004221\uff09\uff1b<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u5316\u7597\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03430843\uff09\uff1b<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03783442\uff09\uff1b<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u540c\u6b65\u653e\u5316\u7597\u7528\u4e8e\u6cbb\u7597\u5c40\u9650\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03957590\uff09\uff1b<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u80c3\u764c\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03777657\uff09\uff1b<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408Sitravatinib\u5bf9\u6bd4\u591a\u897f\u4ed6\u8d5b\u7528\u4e8e\u6cbb\u7597\u4f7f\u7528\u5316\u7597\u548c\u6297PD-\uff08L\uff091\u6297\u4f53\u540e\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671fNSCLC\u60a3\u8005\u76843\u671f\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04921358\uff09\uff1b&nbsp;<\/li>\n<li>Zanidatamab\u8054\u5408\u5316\u7597\u52a0\u6216\u4e0d\u52a0\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597HER2\u9633\u6027\u665a\u671f\u80c3\u764c\u548c\u98df\u7ba1\u764c\u60a3\u8005\u76843\u671f\u8bd5\u9a8c \uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT05152147\uff09\uff1b<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03209973\uff09\uff1b<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597MSI-H\/dMMR\u5b9e\u4f53\u7624\u60a3\u8005\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03736889\uff09\uff1b\u4ee5\u53ca<\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u9f3b\u54bd\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03924986\uff09\u3002&nbsp;<\/li>\n<\/ul>\n<p>\u76ee\u524d\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8fd8\u5f00\u5c55\u4e86\u591a\u9879\u4e0e\u767e\u6d4e\u795e\u5dde\u5728\u7814\u7684\u3001\u5177\u6709\u5b8c\u6574Fc\u529f\u80fd\u7684\u5f3a\u6548TIGIT\u6291\u5236\u5242\u6b27\u53f8\u73c0\u5229\u5355\u6297\u8054\u5408\u7528\u836f\u7684\u8bd5\u9a8c\uff0c\u5305\u62ec\uff1a&nbsp;<\/p>\n<ul type=\"disc\">\n<li>AdvanTIG-301\uff1a\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u3001\u4e0d\u53ef\u5207\u9664\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u76843\u671f\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04866017\uff09\uff1b<\/li>\n<li>AdvanTIG-302\uff1a\u6cbb\u7597\u672a\u7ecf\u6cbb\u7597\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u76843\u671f\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04746924\uff09\uff1b<\/li>\n<li>AdvanTIG-202\uff1a\u6cbb\u7597\u8f6c\u79fb\u6027\u5bab\u9888\u764c\u76842\u671f\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04693234\uff09\uff1b<\/li>\n<li>AdvanTIG-203\uff1a\u6cbb\u7597\u665a\u671f\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\u76842\u671f\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04732494\uff09\uff1b<\/li>\n<li>AdvanTIG-204\uff1a\u6cbb\u7597\u672a\u7ecf\u6cbb\u7597\u7684\u5c40\u9650\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\u76842\u671f\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04952597\uff09\uff1b&nbsp;<\/li>\n<li>AdvanTIG-205\uff1a\u6cbb\u7597\u672a\u7ecf\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u76842\u671f\u8bd5\u9a8c \uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT05014815\uff09\uff1b<\/li>\n<li>AdvanTIG-206\uff1a\u6cbb\u7597\u4e00\u7ebf\u665a\u671f\u809d\u7ec6\u80de\u764c\u76842\u671f\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04948697\uff09\uff1b\u4ee5\u53ca<\/li>\n<li>\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u76841b\u671f\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04047862\uff09\u3002&nbsp;<\/li>\n<\/ul>\n<p><b>\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66<\/b>&nbsp;<\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u6216\u4e0e\u5fd7\u540c\u9053\u5408\u7684\u5408\u4f5c\u4f19\u4f34\u643a\u624b\uff0c\u4e0d\u65ad\u63a8\u52a8\u540c\u7c7b\u6700\u4f73\u6216\u540c\u7c7b\u7b2c\u4e00\u7684\u4e34\u5e8a\u5019\u9009\u836f\u7269\u7814\u53d1\uff0c\u81f4\u529b\u4e8e\u4e3a\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u6709\u6548\u3001\u53ef\u53ca\u4e14\u53ef\u8d1f\u62c5\u7684\u836f\u7269\u3002\u516c\u53f8\u5168\u7403\u4e34\u5e8a\u7814\u53d1\u548c\u533b\u5b66\u4e8b\u52a1\u56e2\u961f\u5df2\u6709\u7ea62,900\u4eba\u4e14\u4ecd\u5728\u4e0d\u65ad\u58ee\u5927\uff0c\u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u56f4\u652f\u6301100\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u5c55\u5f00\uff0c\u5df2\u62db\u52df\u53d7\u8bd5\u8005\u8d85\u8fc714,500\u4eba\u3002\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u6df1\u539a\u3001\u8bd5\u9a8c\u5e03\u5c40\u5e7f\u6cdb\uff0c\u8bd5\u9a8c\u5df2\u8986\u76d6\u5168\u7403\u8d85\u8fc745\u4e2a\u56fd\u5bb6\/\u5730\u533a\uff0c\u4e14\u5747\u7531\u516c\u53f8\u5185\u90e8\u56e2\u961f\u7275\u5934\u3002\u516c\u53f8\u6df1\u8015\u4e8e\u8840\u6db2\u80bf\u7624\u548c\u5b9e\u4f53\u80bf\u7624\u7684\u9776\u5411\u6cbb\u7597\u53ca\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u5f00\u53d1\uff0c\u540c\u65f6\u4e13\u6ce8\u4e8e\u5355\u836f\u7597\u6cd5\u548c\u8054\u5408\u7597\u6cd5\u7684\u63a2\u7d22\u3002\u76ee\u524d\uff0c\u767e\u6d4e\u795e\u5dde\u81ea\u4e3b\u7814\u53d1\u7684\u4e09\u6b3e\u836f\u7269\u5df2\u83b7\u6279\u4e0a\u5e02\uff1a\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\uff08BTK\u6291\u5236\u5242\uff0c\u5df2\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u6b27\u76df\u548c\u82f1\u56fd\u3001\u52a0\u62ff\u5927\u3001\u6fb3\u5927\u5229\u4e9a\u53ca\u5176\u4ed6\u56fd\u9645\u5e02\u573a\u83b7\u6279\u4e0a\u5e02\uff09\u3001\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\uff08\u53ef\u6709\u6548\u907f\u514dFc-\u03b3\u53d7\u4f53\u7ed3\u5408\u7684\u6297PD-1\u6297\u4f53\uff0c\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff09\u53ca\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\uff08PARP\u6291\u5236\u5242\uff0c\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff09\u3002&nbsp;<\/p>\n<p>\u540c\u65f6\uff0c\u767e\u6d4e\u795e\u5dde\u8fd8\u4e0e\u5176\u4ed6\u521b\u65b0\u516c\u53f8\u5408\u4f5c\uff0c\u5171\u540c\u643a\u624b\u63a8\u8fdb\u521b\u65b0\u7597\u6cd5\u7684\u7814\u53d1\uff0c\u4ee5\u6ee1\u8db3\u5168\u7403\u5065\u5eb7\u9700\u6c42\u3002\u5728\u4e2d\u56fd\uff0c\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u9500\u552e\u591a\u6b3e\u7531\u5b89\u8fdb\u3001\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u3001EUSA Pharma\u3001\u767e\u5965\u6cf0\u6388\u6743\u7684\u80bf\u7624\u836f\u7269\u3002\u516c\u53f8\u4e5f\u901a\u8fc7\u4e0e\u5305\u62ecMirati Therapeutics\u3001Seagen\u4ee5\u53caZymeworks\u5728\u5185\u7684\u591a\u5bb6\u516c\u53f8\u5408\u4f5c\uff0c\u66f4\u5927\u7a0b\u5ea6\u6ee1\u8db3\u5f53\u524d\u5168\u7403\u8303\u56f4\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002&nbsp;<\/p>\n<p>2021\u5e741\u6708\uff0c\u767e\u6d4e\u795e\u5dde\u548c\u8bfa\u534e\u5ba3\u5e03\u5408\u4f5c\uff0c\u6388\u4e88\u8bfa\u534e\u5728\u5317\u7f8e\u3001\u6b27\u6d32\u548c\u65e5\u672c\u5171\u540c\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u767e\u6d4e\u795e\u5dde\u7684\u6297PD-1\u6297\u4f53\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u3002\u57fa\u4e8e\u8fd9\u4e00\u5353\u6709\u6210\u6548\u7684\u5408\u4f5c\uff0c\u5305\u62ecFDA\u6b63\u5728\u8bc4\u5ba1\u7684\u65b0\u836f\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\uff08BLA\uff09\uff0c\u767e\u6d4e\u795e\u5dde\u548c\u8bfa\u534e\u4e8e2021\u5e7412\u6708\u5ba3\u5e03\u4e86\u5173\u4e8e\u6b63\u57283\u671f\u5f00\u53d1\u7684\u767e\u6d4e\u795e\u5ddeTIGIT\u6291\u5236\u5242\u6b27\u53f8\u73c0\u5229\u5355\u6297\u7684\u9009\u62e9\u6743\u3001\u5408\u4f5c\u548c\u8bb8\u53ef\u534f\u8bae\u3002\u8bfa\u534e\u548c\u767e\u6d4e\u795e\u5dde\u8fd8\u7b7e\u8ba2\u4e86\u4e00\u9879\u6218\u7565\u5546\u4e1a\u534f\u8bae\uff0c\u901a\u8fc7\u8be5\u534f\u8bae\uff0c\u767e\u6d4e\u795e\u5dde\u5c06\u5728\u4e2d\u56fd\u5883\u5185\u6307\u5b9a\u533a\u57df\u63a8\u5e7f5\u6b3e\u5df2\u83b7\u6279\u7684\u8bfa\u534e\u6297\u80bf\u7624\u836f\u7269\u3002&nbsp;<\/p>\n<p><b>\u5173\u4e8e\u767e\u6d4e\u795e\u5dde<\/b>&nbsp;<\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u662f\u4e00\u5bb6\u7acb\u8db3\u79d1\u5b66\u7684\u5168\u7403\u6027\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u53ef\u8d1f\u62c5\u7684\u521b\u65b0\u836f\u7269\uff0c\u65e8\u5728\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u6548\u679c\uff0c\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u76ee\u524d\u516c\u53f8\u5e7f\u6cdb\u7684\u836f\u7269\u7ec4\u5408\u5305\u62ec40\u591a\u6b3e\u4e34\u5e8a\u5019\u9009\u836f\u7269\u3002\u516c\u53f8\u901a\u8fc7\u52a0\u5f3a\u81ea\u4e3b\u7814\u53d1\u80fd\u529b\u548c\u5408\u4f5c\uff0c\u52a0\u901f\u63a8\u8fdb\u591a\u5143\u3001\u521b\u65b0\u7684\u836f\u7269\u7ba1\u7ebf\u5f00\u53d1\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u57282030\u5e74\u524d\u4e3a\u5168\u740320\u591a\u4ebf\u4eba\u5168\u9762\u6539\u5584\u836f\u7269\u53ef\u53ca\u6027\u3002\u767e\u6d4e\u795e\u5dde\u5728\u5168\u7403\u4e94\u5927\u6d32\u6253\u9020\u4e86\u4e00\u652f\u8d85\u8fc78,000\u4eba\u7684\u56e2\u961f\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a href=\"http:\/\/www.beigene.com.cn\/\" target=\"_blank\" rel=\"nofollow noopener\">http:\/\/www.beigene.com.cn<\/a>\u3002&nbsp;<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b>&nbsp;<\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u6839\u636e\u300a1995\u5e74\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 1995\uff09\u4ee5\u53ca\u5176\u4ed6\u8054\u90a6\u8bc1\u5238\u6cd5\u4e2d\u5b9a\u4e49\u7684\u524d\u77bb\u6027\u58f0\u660e\uff0c\u5305\u62ec\u5173\u4e8e\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5728ESCC\u548cNSCLC\u60a3\u8005\u4e2d\u76843\u671f\u8bd5\u9a8c\u6570\u636e\u3001\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5728ESCC\u548cNSCLC\u60a3\u8005\u4e2d\u7684\u6f5c\u5728\u4e34\u5e8a\u83b7\u76ca\u7684\u58f0\u660e\u3001\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5728\u6b27\u76dfESCC\u548cNSCLC\u7684MAA\u7684\u7533\u62a5\u548c\u6f5c\u5728\u6279\u51c6\u3001\u4e0e\u8bfa\u534e\u5408\u4f5c\u4e0b\u76d1\u7ba1\u9012\u4ea4\u548c\u6279\u51c6\u7684\u6301\u7eed\u8fdb\u5c55\u3001\u767e\u6d4e\u795e\u5dde\u7684\u8fdb\u5c55\u3001\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7684\u9884\u671f\u4e34\u5e8a\u5f00\u53d1\u3001\u76d1\u7ba1\u91cc\u7a0b\u7891\u548c\u5546\u4e1a\u5316\uff0c\u4ee5\u53ca\u5728&quot;\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66&quot;\u548c&quot;\u5173\u4e8e\u767e\u6d4e\u795e\u5dde&quot;\u526f\u6807\u9898\u4e0b\u63d0\u53ca\u7684\u8ba1\u5212\u3001\u627f\u8bfa\u3001\u613f\u671b\u548c\u76ee\u6807\u3002\u8fd9\u4e9b\u56e0\u7d20\u5305\u62ec\u4e86\u4ee5\u4e0b\u4e8b\u9879\u7684\u98ce\u9669\uff1a\u767e\u6d4e\u795e\u5dde\u8bc1\u660e\u5176\u5019\u9009\u836f\u7269\u529f\u6548\u548c\u5b89\u5168\u6027\u7684\u80fd\u529b\uff1b\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u7ed3\u679c\u53ef\u80fd\u4e0d\u652f\u6301\u8fdb\u4e00\u6b65\u5f00\u53d1\u6216\u4e0a\u5e02\u5ba1\u6279\uff1b\u836f\u653f\u90e8\u95e8\u7684\u884c\u52a8\u53ef\u80fd\u4f1a\u5f71\u54cd\u5230\u4e34\u5e8a\u8bd5\u9a8c\u7684\u542f\u52a8\u3001\u65f6\u95f4\u8868\u548c\u8fdb\u5c55\u4ee5\u53ca\u836f\u7269\u4e0a\u5e02\u5ba1\u6279\uff1b\u767e\u6d4e\u795e\u5dde\u7684\u4e0a\u5e02\u836f\u7269\u53ca\u5019\u9009\u836f\u7269\uff08\u5982\u80fd\u83b7\u6279\uff09\u83b7\u5f97\u5546\u4e1a\u6210\u529f\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u83b7\u5f97\u548c\u7ef4\u62a4\u5bf9\u5176\u836f\u7269\u548c\u6280\u672f\u7684\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u4f9d\u8d56\u7b2c\u4e09\u65b9\u8fdb\u884c\u836f\u7269\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5176\u4ed6\u670d\u52a1\u7684\u60c5\u51b5\uff1b\u767e\u6d4e\u795e\u5dde\u53d6\u5f97\u76d1\u7ba1\u5ba1\u6279\u548c\u5546\u4e1a\u5316\u533b\u836f\u4ea7\u54c1\u7684\u6709\u9650\u7ecf\u9a8c\uff0c\u53ca\u5176\u83b7\u5f97\u8fdb\u4e00\u6b65\u7684\u8425\u8fd0\u8d44\u91d1\u4ee5\u5b8c\u6210\u5019\u9009\u836f\u7269\u5f00\u53d1\u548c\u5b9e\u73b0\u5e76\u4fdd\u6301\u76c8\u5229\u7684\u80fd\u529b\uff1b\u65b0\u51a0\u80ba\u708e\u5168\u7403\u5927\u6d41\u884c\u5bf9\u767e\u6d4e\u795e\u5dde\u7684\u4e34\u5e8a\u5f00\u53d1\u3001\u76d1\u7ba1\u3001\u5546\u4e1a\u5316\u8fd0\u8425\u3001\u751f\u4ea7\u4ee5\u53ca\u5176\u4ed6\u4e1a\u52a1\u5e26\u6765\u7684\u5f71\u54cd\uff1b\u767e\u6d4e\u795e\u5dde\u5728\u6700\u8fd1\u5e74\u5ea6\u62a5\u544a\u768410-K\u8868\u683c\u4e2d&quot;\u98ce\u9669\u56e0\u7d20&quot;\u7ae0\u8282\u91cc\u66f4\u5168\u9762\u8ba8\u8bba\u7684\u5404\u7c7b\u98ce\u9669\uff1b\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u671f\u540e\u5448\u62a5\u4e2d\u5173\u4e8e\u6f5c\u5728\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8ba8\u8bba\u3002\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u4ec5\u53ca\u4e8e\u65b0\u95fb\u7a3f\u53d1\u5e03\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6d4e\u795e\u5dde\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u8be5\u7b49\u4fe1\u606f\u3002&nbsp;<\/p>\n<p><sup><sup>[1]<\/sup><\/sup> Wong, M.C.S., Hamilton, W., Whiteman, D.C.&nbsp;<i>et al.<\/i>&nbsp;Global Incidence and mortality of oesophageal cancer and their correlation with socioeconomic indicators temporal patterns and trends in 41 countries.&nbsp;<i>Sci Rep<\/i>&nbsp;<b>8,&nbsp;<\/b>4522 (2018). <u><a href=\"https:\/\/doi.org\/10.1038\/s41598-018-19819-8\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1038\/s41598-018-19819-8<\/a><\/u><\/p>\n<p>ii &nbsp;<u><a href=\"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/full\/10.3322\/caac.21660\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/full\/10.3322\/caac.21660<\/a><\/u><\/p>\n<p><sup>iii<\/sup> <u><a href=\"https:\/\/www.thelancet.com\/journals\/langas\/article\/PIIS2468-1253(20)30007-8\/fulltext\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.thelancet.com\/journals\/langas\/article\/PIIS2468-1253(20)30007-8\/fulltext<\/a><\/u><\/p>\n<p><sup>iv <\/sup>Codipilly DC et al. Gastrointest Endosc. 2018 Sep; 88(3): 413\u2013426.<\/p>\n<p><sup>v<\/sup> Abnet CC et al. Gastroenterology. 2018 Jan; 154(2): 360\u2013373.<\/p>\n<p><sup>vi<\/sup> Globocan 2020 accessed 3.22<\/p>\n<p><sup>vii <\/sup>American Cancer Society. <u><a href=\"https:\/\/www.cancer.org\/cancer\/lung-cancer\/about\/what-is.html\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.cancer.org\/cancer\/lung-cancer\/about\/what-is.html<\/a><\/u><\/p>\n<p><sup>viii<\/sup> <u><a href=\"https:\/\/www.esmo.org\/content\/download\/7252\/143219\/1\/EN-Non-Small-Cell-Lung-Cancer-Guide-for-Patients.pdf\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.esmo.org\/content\/download\/7252\/143219\/1\/EN-Non-Small-Cell-Lung-Cancer-Guide-for-Patients.pdf<\/a><\/u><\/p>\n<p><sup>ix <\/sup>&nbsp;U.S. National Institute of Health, National Cancer Institute. SEER Cancer Statistics Review, 1975\u20132015.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; \u8fd9\u662f\u767e\u6cfd\u5b89&reg;\u5728\u6b27\u6d32\u7684\u9996\u6b21\u7533\u62a5\uff0c\u4e5f\u662f\u8bfa\u534e\u7ee7\u83b7\u5f97\u8be5\u4ea7\u54c1\u5728\u5317\u7f8e\u3001\u6b27\u6d32\u548c\u65e5\u672c\u5408\u4f5c\u6388\u6743\u540e\u5728\u6b27\u6d32\u7684\u9996\u6b21\u7533\u62a5&nbsp; &nbsp; \u4e2d\u56fd\u5317\u4eac\u3001\u745e\u58eb\u5df4\u585e\u5c14\u548c\u7f8e\u56fd\u9ebb\u7701\u5251\u68652022\u5e744\u67086\u65e5 &nbsp;\/\u7f8e\u901a\u793e\/ &#8212; \u767e\u6d4e\u795e\u5dde\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff1b\u4e0a\u4ea4\u6240\u4ee3\u7801\uff1a688235\uff09\u662f\u4e00\u5bb6\u7acb\u8db3\u4e8e\u79d1\u5b66\u7684\u5168\u7403\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u521b\u65b0\u3001\u53ef\u8d1f\u62c5\u7684\u836f\u7269\uff0c\u65e8\u5728\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u6548\u679c\uff0c\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u516c\u53f8\u4e8e\u4eca\u65e5\u5ba3\u5e03\u767e\u6cfd\u5b89&reg;\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u5168\u8eab\u5316\u7597\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\uff08ESCC\uff09\u60a3\u8005\uff0c\u4ee5\u53ca\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\uff08MAA\uff09\u5df2\u83b7\u5f97\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u53d7\u7406\uff0c\u76ee\u524d\u6b63\u5728\u5ba1\u8bc4\u4e2d\u3002\u8be5\u7533\u8bf7\u7531\u767e\u6cfd\u5b89&reg;\u6b27\u6d32\u8bb8\u53ef\u6301\u6709\u4eba\u8bfa\u534e\u63d0\u4ea4\u3002\u5176\u4e2d\uff0c\u9488\u5bf9NSCLC\u9012\u4ea4\u7684\u76f8\u5173\u9002\u5e94\u75c7\u5305\u62ec\uff1a&nbsp; 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\u767e\u6cfd\u5b89&reg;\u7528\u4e8eESCC\u7684MAA\u9012\u4ea4\u662f\u57fa\u4e8e\u767e\u6d4e\u795e\u5ddeRATIONALE 302\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u8fd9\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6027\u3001\u591a\u4e2d\u5fc3\u7684\u5168\u74033\u671f\u8bd5\u9a8c\uff08NCT03430843\uff09\uff0c\u65e8\u5728\u8bc4\u4ef7\u767e\u6cfd\u5b89&reg;\u76f8\u6bd4\u7814\u7a76\u8005\u9009\u62e9\u7684\u5316\u7597\u65b9\u6848\u7528\u4e8e\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u4e8c\u7ebf\u6cbb\u7597\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8be5\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u5df2\u57282021\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\uff08ASCO 2021\uff09\u4e0a\u516c\u5e03\u3002\u9012\u4ea4\u8d44\u6599\u4e2d\u8fd8\u5305\u62ec\u57287\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d1972\u4f8b\u63a5\u53d7\u767e\u6cfd\u5b89&reg;\u5355\u836f\u6cbb\u7597\u60a3\u8005\u7684\u5b89\u5168\u6027\u6570\u636e\u3002\u6b64\u5916\uff0c\u7f8e\u56fdFDA\u76ee\u524d\u6b63\u5728\u5ba1\u8bc4\u8be5\u9002\u5e94\u75c7\u7684\u65b0\u836f\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\uff08BLA\uff09\u3002\u9664\u6b27\u76df\u548c\u7f8e\u56fd\u5916\uff0c\u767e\u6cfd\u5b89&reg;\u7528\u4e8eESCC\u60a3\u8005\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u4e5f\u5728\u4e2d\u56fd\u83b7\u5f97\u53d7\u7406\u4e14\u6b63\u5728\u5ba1\u8bc4\u4e2d\u3002&nbsp; \u5173\u4e8e\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\uff08ESCC\uff09&nbsp; &nbsp;\u5728\u5168\u7403\u8303\u56f4\u5185\uff0c\u98df\u7ba1\u764c\u662f\u6700\u5e38\u89c1\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\uff0c\u4e5f\u662f\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002\u21702020\u5e74\uff0c\u98df\u7ba1\u764c\u7684\u53d1\u75c5\u7387\u5728\u6240\u6709\u764c\u75c7\u53d1\u75c5\u7387\u4e2d\u6392\u540d\u7b2c\u4e03\uff08604,000\u4f8b\u65b0\u53d1\u75c5\u4f8b\uff09\uff0c\u603b\u6b7b\u4ea1\u7387\u6392\u540d\u7b2c\u516d\uff08544,000\u4f8b\u6b7b\u4ea1\u75c5\u4f8b\uff09\uff0c\u8fd9\u8868\u660e\uff0c\u6bcf18\u4f8b\u764c\u75c7\u6b7b\u4ea1\u4e2d\u67091\u4f8b\u662f\u56e0\u98df\u7ba1\u764c\u6b7b\u4ea1\u3002\u2171&nbsp; \u6839\u636e\u764c\u7ec6\u80de\u4f4d\u7f6e\u7684\u4e0d\u540c\uff0c\u98df\u7ba1\u764c\u4e3b\u8981\u5206\u4e3a\u4e24\u79cd\u7c7b\u578b\uff1a\u9cde\u72b6\u7ec6\u80de\u764c\uff08ESCC\uff09\u548c\u817a\u764c\uff08EAC\uff09\u3002\u2172\u7531\u4e8e\u8bb8\u591a\u60a3\u8005\u5728\u786e\u8bca\u65f6\u5df2\u5904\u4e8e\u75be\u75c5\u665a\u671f\uff0cESCC\u60a3\u8005\u7684\u603b\u4f53\u9884\u540e\u8f83\u4e0d\u7406\u60f3\uff0c\u6cbb\u7597\u6781\u5177\u6311\u6218\u6027\u3002\u2173\uff0c\u2174&nbsp; \u5173\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09&nbsp; \u5728\u5168\u7403\uff0c\u80ba\u764c\u662f\u7b2c\u4e8c\u5927\u5e38\u89c1\u7684\u764c\u75c7\u7c7b\u578b\uff0c\u4e5f\u662f\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002\u2175\u5728\u6b27\u6d32\uff0c\u80ba\u764c\u662f\u7b2c\u4e09\u5927\u5e38\u89c1\u764c\u75c7\u3002\u5728\u6240\u6709\u80ba\u764c\u75c5\u4f8b\u4e2d\uff0cNSCLC\u75c5\u4f8b\u7ea6\u536085 ~ 90%\u3002\u2176\u57282018\u5e74\uff0c\u6b27\u6d32\u65b0\u8bca\u65ad\u80ba\u764c\u75c5\u4f8b\u6570\u9884\u4f30\u8d85\u8fc747\u4e07\u4f8b\uff08Ferlay et al., 2018\uff09\u3002\u2177&nbsp;IIIB\u671f\u548cIV\u671fNSCLC\u60a3\u8005\u7ecf\u6cbb\u540e\u7684\u4e94\u5e74\u751f\u5b58\u7387\u5206\u522b\u4ec5\u4e3a5%\u548c2%\u3002\u2178&nbsp; \u5173\u4e8e\u767e\u6cfd\u5b89&reg;\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09&nbsp; \u767e\u6cfd\u5b89&reg;\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u662f\u4e00\u6b3e\u4eba\u6e90\u5316IgG4\u6297\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f531\uff08PD-1\uff09\u5355\u514b\u9686\u6297\u4f53\uff0c\u8bbe\u8ba1\u76ee\u7684\u65e8\u5728\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u4e0e\u5de8\u566c\u7ec6\u80de\u4e2d\u7684Fc\u03b3\u53d7\u4f53\u7ed3\u5408\u3002\u4e34\u5e8a\u524d\u6570\u636e\u8868\u660e\uff0c\u5de8\u566c\u7ec6\u80de\u4e2d\u7684Fc\u03b3\u53d7\u4f53\u7ed3\u5408\u4e4b\u540e\u4f1a\u6fc0\u6d3b\u6297\u4f53\u4f9d\u8d56\u7ec6\u80de\u4ecb\u5bfc\u6740\u4f24T\u7ec6\u80de\uff0c\u4ece\u800c\u964d\u4f4e\u4e86PD-1\u6297\u4f53\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u767e\u6cfd\u5b89&reg;\u662f\u7b2c\u4e00\u6b3e\u7531\u767e\u6d4e\u795e\u5dde\u7684\u514d\u75ab\u80bf\u7624\u751f\u7269\u5e73\u53f0\u7814\u53d1\u7684\u836f\u7269\uff0c\u76ee\u524d\u6b63\u8fdb\u884c\u5355\u836f\u53ca\u8054\u5408\u7597\u6cd5\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u5f00\u53d1\u4e00\u7cfb\u5217\u9488\u5bf9\u5b9e\u4f53\u7624\u548c\u8840\u6db2\u80bf\u7624\u7684\u5e7f\u6cdb\u9002\u5e94\u75c7\u3002&nbsp; 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