{"id":66795,"date":"2022-04-04T09:27:00","date_gmt":"2022-04-04T02:27:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022040409270066795"},"modified":"2022-04-04T17:56:45","modified_gmt":"2022-04-04T09:56:45","slug":"%e5%bc%80%e6%8b%93%e8%8d%af%e4%b8%9a%e6%99%ae%e5%85%8b%e9%b2%81%e8%83%ba%e5%92%8cc-myc-degrader%e6%9c%80%e6%96%b0%e7%a0%94%e7%a9%b6%e6%95%b0%e6%8d%ae%e5%b0%86%e4%ba%ae%e7%9b%b82022-aacr","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022040409270066795","title":{"rendered":"\u5f00\u62d3\u836f\u4e1a\u666e\u514b\u9c81\u80fa\u548cc-Myc Degrader\u6700\u65b0\u7814\u7a76\u6570\u636e\u5c06\u4eae\u76f82022 AACR"},"content":{"rendered":"<p><p>\u4e2d\u56fd\u82cf\u5dde2022\u5e744\u67084\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; <b>\u5f00\u62d3\u836f\u4e1a\uff08\u80a1\u7968\u4ee3\u7801\uff1a9939.HK\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u6f5c\u5728\u540c\u7c7b\u9996\u521b\u548c\u540c\u7c7b\u6700\u4f73\u521b\u65b0\u836f\u7269\u7814\u53d1\u53ca\u4ea7\u4e1a\u5316\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5ba3\u5e03\u5c06\u4e8e<\/b><b>\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f4<\/b><b>2022\u5e744\u67088\u65e5-13\u65e5\u4e3e\u884c\u7684\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR<\/b><b>\uff09<\/b><b>\u5e74\u4f1a\u4e0a\uff0c\u901a\u8fc7\u58c1\u62a5\uff08<\/b><b>E-Poster<\/b><b>\uff09<\/b><b>\u7684\u65b9\u5f0f\u516c\u5e03\u666e\u514b\u9c81\u80fa\u6cbb\u7597\u65b0\u51a0\u7684\u4f5c\u7528\u673a\u5236\u548c<\/b><b>c-Myc degrader\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e\u3002<\/b><\/p>\n<ul type=\"disc\">\n<li><b>\u58c1\u62a5\u5c55\u793a<\/b>&nbsp;<\/li>\n<\/ul>\n<p><b>\u6458\u8981\u6807\u9898\uff1a<\/b>&nbsp;<b><i>Mechanisms of action (MOA) for proxalutamide, an androgen receptor (AR) antagonist, for the treatment of mild, moderate and severe COVID-19 patients<\/i><\/b><\/p>\n<p>\u96c4\u6fc0\u7d20\u53d7\u4f53\uff08AR\uff09\u62ee\u6297\u5242\u666e\u514b\u9c81\u80fa\u7528\u4e8e\u6cbb\u7597\u8f7b\u4e2d\u3001\u91cd\u75c7\u65b0\u51a0\u60a3\u8005\u7684\u4f5c\u7528\u673a\u5236\uff08MOA\uff09<\/p>\n<p><b>\u6458\u8981\u7f16\u53f7\uff1a<\/b>5274<\/p>\n<p><b>\u4f1a\u8bae\u4e3b\u9898\uff1a<\/b>COVID-19 and Cancer\uff08\u65b0\u51a0\u4e0e\u764c\u75c7\uff09<\/p>\n<p><b>\u62a5\u544a\u65f6\u95f4\uff1a<\/b>\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f42022\u5e744\u67088\u65e5\u4e0b\u534812:00-1:00<\/p>\n<p><b>\u6458\u8981\u94fe\u63a5\uff1a<\/b><a href=\"https:\/\/www.abstractsonline.com\/pp8\/#!\/10517\/presentation\/18533\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.abstractsonline.com\/pp8\/#!\/10517\/presentation\/18533<\/a><br \/><b>\u6458\u8981\u6807\u9898\uff1a<\/b><b><i>Discovery and evaluation of GT19630, a c-Myc\/GSPT1 cereblon E3 ligase modulator (CELMoD) , for targeting Myc-driven blood cancers and small cell lung cancers (SCLC)<\/i><\/b><\/p>\n<p>\u53d1\u73b0\u548c\u8bc4\u4ef7\u9488\u5bf9c-Myc\u9a71\u52a8\u7684\u8840\u6db2\u764c\u75c7\u548c\u5c0f\u7ec6\u80de\u80ba\u764c\uff08SCLC\uff09\u7684c-Myc\/GSPT1&nbsp; cereblon E3 ligase modulator (CELMoD) GT19630<\/p>\n<p><b>\u6458\u8981\u7f16\u53f7\uff1a<\/b>5479<\/p>\n<p><b>\u4f1a\u8bae\u4e3b\u9898\uff1a<\/b>Small Molecule Therapeutic Agents\uff08\u5c0f\u5206\u5b50\u6cbb\u7597\u836f\u7269\uff09<\/p>\n<p><b>\u62a5\u544a\u65f6\u95f4\uff1a<\/b>\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f42022\u5e744\u67088\u65e5\u4e0b\u534812:00-1:00<\/p>\n<p><b>\u6458\u8981\u94fe\u63a5\uff1a<\/b><a href=\"https:\/\/www.abstractsonline.com\/pp8\/#!\/10517\/presentation\/18624\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.abstractsonline.com\/pp8\/#!\/10517\/presentation\/18624<\/a><\/p>\n<p>\u66f4\u591a\u4f1a\u8bae\u8be6\u60c5\uff0c\u8bf7\u767b\u5f55AACR\u5b98\u7f51\u67e5\u9605\u3002<\/p>\n<p><b>\u5173\u4e8e\u5f00\u62d3\u836f\u4e1a<\/b><\/p>\n<p>\u5f00\u62d3\u836f\u4e1a\u6210\u7acb\u4e8e2009\u5e74\uff0c\u4e13\u6ce8\u53d1\u5c55\u6f5c\u5728\u201cbest-in-class\u201d\u548c\u201cfirst-in-class\u201d\u521b\u65b0\u836f\u7269\u7684\u7814\u53d1\u53ca\u4ea7\u4e1a\u5316\uff0c\u81f4\u529b\u6210\u4e3a\u521b\u65b0\u7597\u6cd5\u7814\u7a76\u3001\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u9886\u519b\u4f01\u4e1a\u3002\u516c\u53f8\u7ecf\u8fc7\u591a\u5e74\u7684\u53d1\u5c55\uff0c\u4ee5\u96c4\u6fc0\u7d20\u53d7\u4f53(AR)\u76f8\u5173\u75be\u75c5\u4e3a\u6838\u5fc3\uff0c\u7814\u53d1\u591a\u901a\u9053\u4ea7\u54c1\u7ec4\u5408\uff0c\u4ea7\u54c1\u8986\u76d6\u5168\u7403\u9ad8\u53d1\u75c5\u7387\u764c\u75c7\u53ca\u5176\u5b83\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u7684\u75be\u75c5\u9886\u57df\uff0c\u5305\u62ec\u65b0\u51a0\u80ba\u708e\u3001\u524d\u5217\u817a\u764c\u3001\u4e73\u817a\u764c\u3001\u809d\u764c\u3001\u8131\u53d1\u548c\u75e4\u75ae\u7b49\u3002\u5f00\u62d3\u836f\u4e1a\u524d\u77bb\u6027\u5e03\u5c40\u4e86\u5305\u542b\u5c0f\u5206\u5b50\u521b\u65b0\u836f\u3001\u751f\u7269\u521b\u65b0\u836f\u53ca\u8054\u5408\u7597\u6cd5\u7684\u591a\u5143\u5316\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ec7\u6b3e\u6b63\u5728\u5f00\u5c55\u4e34\u5e8a\u7814\u7a76\u7684\u4ea7\u54c1\uff0c\u5982\u4e24\u6b3e\u96c4\u6fc0\u7d20\u53d7\u4f53(AR)\u62ee\u6297\u5242\u3001ALK-1\u5355\u6297\u3001AR-PROTAC\u5316\u5408\u7269\u3001PD-L1\/TGF-\u03b2\u53cc\u9776\u70b9\u6297\u4f53\u3001mTOR\u6fc0\u9176\u9776\u5411\u6291\u5236\u5242\u548cHedgehog\u6291\u5236\u5242\uff0c\u4ee5\u53ca\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u524d\u7814\u7a76\u7684ALK-1\/VEGF\u53cc\u6297\u548cc-Myc\u6291\u5236\u5242\u7b49\u3002\u516c\u53f8\u5728\u5168\u7403\u62e5\u6709\u5df2\u83b7\u5f97\u53ca\u7533\u8bf7\u4e2d\u768480\u591a\u9879\u4e13\u5229\uff0c\u591a\u4e2a\u9879\u76ee\u88ab\u5217\u4e3a\u56fd\u5bb6\u5341\u4e8c\u4e94\u3001\u5341\u4e09\u4e94<span id=\"spanHghltc21e\">\u201c<\/span>\u91cd\u5927\u65b0\u836f\u521b\u5236<span id=\"spanHghlt75cc\">\u201d<\/span>\u4e13\u9879\u30022020\u5e745\u670822\u65e5\uff0c\u5f00\u62d3\u836f\u4e1a\u6b63\u5f0f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u6302\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a9939.HK\u3002\u6b22\u8fce\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1a<a href=\"http:\/\/www.kintor.com.cn\/\" target=\"_blank\" rel=\"nofollow noopener\">www.kintor.com.cn<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u56fd\u82cf\u5dde2022\u5e744\u67084\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u5f00\u62d3\u836f\u4e1a\uff08\u80a1\u7968\u4ee3\u7801\uff1a9939.HK\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u6f5c\u5728\u540c\u7c7b\u9996\u521b\u548c\u540c\u7c7b\u6700\u4f73\u521b\u65b0\u836f\u7269\u7814\u53d1\u53ca\u4ea7\u4e1a\u5316\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5ba3\u5e03\u5c06\u4e8e\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f42022\u5e744\u67088\u65e5-13\u65e5\u4e3e\u884c\u7684\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u5e74\u4f1a\u4e0a\uff0c\u901a\u8fc7\u58c1\u62a5\uff08E-Poster\uff09\u7684\u65b9\u5f0f\u516c\u5e03\u666e\u514b\u9c81\u80fa\u6cbb\u7597\u65b0\u51a0\u7684\u4f5c\u7528\u673a\u5236\u548cc-Myc degrader\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e\u3002 \u58c1\u62a5\u5c55\u793a&nbsp; \u6458\u8981\u6807\u9898\uff1a&nbsp;Mechanisms of action (MOA) for proxalutamide, an androgen receptor (AR) antagonist, for the treatment of mild, moderate and severe COVID-19 patients \u96c4\u6fc0\u7d20\u53d7\u4f53\uff08AR\uff09\u62ee\u6297\u5242\u666e\u514b\u9c81\u80fa\u7528\u4e8e\u6cbb\u7597\u8f7b\u4e2d\u3001\u91cd\u75c7\u65b0\u51a0\u60a3\u8005\u7684\u4f5c\u7528\u673a\u5236\uff08MOA\uff09 \u6458\u8981\u7f16\u53f7\uff1a5274 \u4f1a\u8bae\u4e3b\u9898\uff1aCOVID-19 and Cancer\uff08\u65b0\u51a0\u4e0e\u764c\u75c7\uff09 \u62a5\u544a\u65f6\u95f4\uff1a\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f42022\u5e744\u67088\u65e5\u4e0b\u534812:00-1:00 \u6458\u8981\u94fe\u63a5\uff1ahttps:\/\/www.abstractsonline.com\/pp8\/#!\/10517\/presentation\/18533\u6458\u8981\u6807\u9898\uff1aDiscovery and evaluation of GT19630, a c-Myc\/GSPT1 cereblon E3 ligase modulator (CELMoD) , for targeting Myc-driven blood cancers and small cell lung&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2022040409270066795\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-66795","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/66795","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=66795"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/66795\/revisions"}],"predecessor-version":[{"id":66796,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/66795\/revisions\/66796"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=66795"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=66795"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=66795"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}