{"id":66576,"date":"2022-03-31T17:05:00","date_gmt":"2022-03-31T10:05:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022033117050066576"},"modified":"2022-04-01T18:20:56","modified_gmt":"2022-04-01T10:20:56","slug":"%e8%85%be%e7%9b%9b%e5%8d%9a%e8%8d%af%e5%9c%a82022%e5%b9%b4%e4%ba%9a%e5%a4%aa%e8%82%9d%e8%84%8f%e7%a0%94%e7%a9%b6%e5%ad%a6%e4%bc%9a%e4%bc%9a%e8%ae%ae%ef%bc%88apasl%ef%bc%89%e4%b8%8a%e5%85%ac%e5%b8%83br","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022033117050066576","title":{"rendered":"\u817e\u76db\u535a\u836f\u57282022\u5e74\u4e9a\u592a\u809d\u810f\u7814\u7a76\u5b66\u4f1a\u4f1a\u8bae\uff08APASL\uff09\u4e0a\u516c\u5e03BRII-835\uff08VIR-2218\uff09\u5728\u4e2d\u56fd\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u4e2d\u7814\u7a76\u7684\u6700\u65b0\u6570\u636e"},"content":{"rendered":"<p><p><span class=\"xn-subheadline\">\u65b0\u6570\u636e\u8868\u660e\uff0cBRII-835\uff08VIR-2218\uff09\u5728\u4e2d\u56fd\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u4e14\u8840\u6e05HBsAg\u6c34\u5e73\u660e\u663e\u964d\u4f4e<\/span><\/p>\n<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/Logo-325.jpg\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span id=\"spanHghlt1fc0\">\u5317\u4eac\u548c\u5317\u5361\u7f57\u83b1\u7eb3\u5dde\u8fbe\u52d2\u59c6\u5e02<\/span>2022\u5e743\u670831\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; <a target=\"_blank\" href=\"http:\/\/cn.briibio.com\/index.php\" rel=\"nofollow noopener\">\u817e\u76db\u535a\u836f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/a><a target=\"_blank\" href=\"https:\/\/www.briibio.com\/index.php\" rel=\"nofollow noopener\">Brii Biosciences Limited<\/a>\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u817e\u76db\u535a\u836f\u201d\u6216\u201c\u516c\u53f8\u201d\uff0c\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u9488\u5bf9\u60a3\u8005\u672a\u88ab\u6ee1\u8db3\u7684\u9700\u6c42\u53ca\u91cd\u5927\u516c\u5171\u536b\u751f\u75be\u75c5\u5f00\u53d1\u521b\u65b0\u7597\u6cd5\u7684\u8de8\u56fd\u4f01\u4e1a\uff0c\u4eca\u65e5\u57282022\u5e74\u4e9a\u592a\u809d\u810f\u7814\u7a76\u5b66\u4f1a\u7b2c&nbsp;31 \u5c4a\u4f1a\u8bae\uff08APASL\uff09\u4e0a\uff0c\u516c\u5e03\u4e86\u5176\u4e34\u5e8a\u9636\u6bb5\u5c0f\u5e72\u6270\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09BRII-835\uff08VIR-2218\uff09\u5728\u4e2d\u56fd\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u4e00\u9879\u4e8c\u671f\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\u7684\u6700\u65b0\u6570\u636e\uff0c\u8be5\u4f1a\u8bae\u4e8e3 \u6708 30 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id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p>\u6570\u636e\u663e\u793a\uff0c\u5728\u63a5\u53d7\u4e24\u6b21BRII-835\uff08VIR-2218\uff09\u7ed9\u836f\u540e\uff0c\u4e2d\u56fd\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u7684HBV\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6c34\u5e73\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u964d\u4f4e\uff0c\u5e76\u4e14\u5728HBeAg\u9634\u6027\u548cHBeAg\u9633\u6027\u60a3\u8005\u4e2dHBsAg\u6c34\u5e73\u964d\u4f4e\u7a0b\u5ea6\u76f8\u8fd1\u3002\u6b64\u5916\uff0cBRII-835\uff08VIR-2218\uff09\u8010\u53d7\u6027\u826f\u597d\uff0c\u6240\u6709\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\u5747\u4e3a\u8f7b\u6216\u4e2d\u5ea6\uff0c\u672a\u89c2\u5bdf\u5230\u5177\u6709\u663e\u8457\u4e34\u5e8a\u610f\u4e49\u7684\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08ALT\uff09\u5347\u9ad8\u3002<\/p>\n<p>\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u53cb\u8c0a\u533b\u9662\u809d\u75c5\u7814\u7a76\u4e2d\u5fc3\u8d3e\u7ee7\u4e1c\u6559\u6388\u8868\u793a\uff1a\u201c\u5728\u672c\u7814\u7a76\u4e2d\uff0cBRII-835\uff08VIR-2218\uff09\u4e24\u6b21\u7ed9\u836f\u540e\uff0cHBeAg\u9634\u6027\u548cHBeAg\u9633\u6027\u4e2d\u56fd\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u7684\u8840\u6e05HBsAg\u6c34\u5e73\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u964d\u4f4e\uff0c\u8fd9\u4e0e\u4e4b\u524d\u5728\u5176\u4ed6\u4eba\u79cd\/\u79cd\u65cf\u4e2d\u7684\u7814\u7a76\u7ed3\u679c\u4e00\u81f4\u3002\u5728\u8fd9\u4e9b\u6570\u636e\u7684\u652f\u6301\u4e0b\uff0c\u6211\u4eec\u8ba4\u4e3aBRII-835\uff08VIR-2218\uff09\u8fd9\u7c7b\u53ef\u964d\u4f4e\u7531\u6162\u6027HBV\u611f\u67d3\u5f15\u8d77\u7684\u9ad8\u75c5\u6bd2\u6297\u539f\u8d1f\u8377\u7684\u65b0\u578b\u836f\u7269\uff0c\u6709\u6f5c\u529b\u6210\u4e3a\u6162\u6027HBV\u529f\u80fd\u6027\u6cbb\u6108\u65b9\u6848\u7684\u57fa\u77f3\uff0c\u4ece\u800c\u6709\u52a9\u89e3\u51b3\u6162\u6027HBV\u611f\u67d3\u6240\u5e26\u6765\u7684\u5168\u7403\u6027\u91cd\u5927\u516c\u5171\u536b\u751f\u95ee\u9898\u3002\u201d<\/p>\n<p>\u817e\u76db\u535a\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u4e25\u7acb\u535a\u58eb\u8868\u793a\uff1a\u201c\u5f00\u53d1\u6162\u6027HBV\u529f\u80fd\u6027\u6cbb\u6108\u65b9\u6848\u662f\u817e\u76db\u535a\u836f\u7684\u76ee\u6807\u4e4b\u4e00\u3002\u6211\u4eec\u6b63\u5728\u8fdb\u884c\u591a\u9879\u7814\u7a76\u4ee5\u8bc4\u4f30\u4e0d\u540c\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6848\uff0c\u6211\u4eec\u5f88\u9ad8\u5174\u672c\u7814\u7a76\u7684\u6570\u636e\u652f\u6301siRNA\u4f5c\u4e3a\u8054\u5408\u6cbb\u7597\u65b9\u6848\u7684\u9aa8\u5e72\u7684\u6f5c\u529b\u3002\u6211\u4eec\u671f\u5f85\u5728\u4eca\u5e74\u5e95\u80fd\u591f\u4ece\u8fd9\u4e9b\u7814\u7a76\u4e2d\u770b\u5230\u6709\u5173BRII-835\uff08VIR-2218\uff09\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u5408\u4f7f\u7528\u7684\u66f4\u591a\u6570\u636e\u3002\u201d<\/p>\n<p><b>\u6458\u8981<\/b><b>\u7f16<\/b><b>\u53f7\uff1a<\/b>L-OP-1324<\/p>\n<p><b>\u62a5\u544a<\/b><b>\u6807\u9898<\/b><b>\uff1a<\/b>&nbsp;\u9776\u5411X\u57fa\u56e0\u7684RNAi \u7597\u6cd5BRII-835\uff08VIR-2218\uff09\u5728\u4e2d\u56fd\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u4e2d\u4e24\u6b21\u7ed9\u836f\uff08\u95f4\u9694\u4e00\u6708\uff09\u7684\u5b89\u5168\u6027\u548c\u6297\u75c5\u6bd2\u6d3b\u6027<\/p>\n<p><b>\u4e3b<\/b><b>\u8bb2<\/b><b>\u4eba\uff1a<\/b>\u8d3e\u7ee7\u4e1c\u6559\u6388\uff0cMD, Ph.D.\uff0c\u9996\u90fd\u533b\u79d1\u5927\u5b66\u533b\u5b66\u6559\u6388\uff0c\u5317\u4eac\u53cb\u8c0a\u533b\u9662\u809d\u75c5\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb<\/p>\n<ul type=\"disc\">\n<li>\u572816\u4f8b\u8fbe\u5230\u75c5\u6bd2\u5b66\u6291\u5236\u7684\u4e2d\u56fd\u975e\u809d\u786c\u5316\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u4e2d\uff0c\u63a5\u53d7\u4e24\u6b21\uff08\u95f4\u9694\u4e00\u6708\uff09\u76ae\u4e0b\u6ce8\u5c04BRII-835\uff08VIR-2218\uff09\u7ed9\u836f\uff0c\u663e\u793a\u51fa\u5176\u826f\u597d\u7684\u8010\u53d7\u6027 <\/li>\n<li>\u672b\u6b21\u7ed9\u836f\u540e12\u5468\u65f6\uff0c\u5728\u63a5\u53d750 mg\u548c100 mg\u5242\u91cfBRII-835\uff08VIR-2218\uff09\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u5e73\u5747HBsAg\u964d\u5e45\u5206\u522b\u4e3a\uff1aHBeAg\u9634\u6027\u60a3\u8005\u4e3a1.02 log<sub>10<\/sub> IU\/mL\u548c1.22 log<sub>10 <\/sub>IU\/mL\uff0cHBeAg\u9633\u6027\u60a3\u8005\u4e3a0.70 log<sub>10 <\/sub>IU\/mL\u548c1.15 log<sub>10 <\/sub>IU\/mL <\/li>\n<li>\u672b\u6b21\u7ed9\u836f\u540e12\u5468HBsAg\u6c34\u5e73\u964d\u4f4e&gt;1 log<sub>10<\/sub> IU\/mL\u7684\u6240\u6709\u60a3\u8005\uff0c\u8840\u6e05HBsAg\u6c34\u5e73\u81f3\u7b2c48\u5468\u59cb\u7ec8\u4f4e\u4e8e\u57fa\u7ebf\u6c34\u5e73<\/li>\n<\/ul>\n<p><b>\u5173\u4e8e<\/b><b>BRII-835\uff08VIR-2218\uff09<\/b><\/p>\n<p>BRII-835\uff08VIR-2218\uff09\u662f\u4e00\u79cd\u7ecf\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\u7684\u9776\u5411HBV\u7684siRNA\u7814\u7a76\u6027\u836f\u7269\uff0c\u5176\u4ecb\u5bfcRNA\u5e72\u6270\uff08RNAi\uff09\uff0c\u5177\u6709\u5bf9HBV\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u548c\u8bf1\u5bfc\u6709\u6548\u514d\u75ab\u5e94\u7b54\u7684\u6f5c\u529b\u3002\u5b83\u662f\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u7684\u91c7\u7528\u589e\u5f3a\u578b\u7a33\u5b9a\u5316\u5b66+\uff08ESC+\uff09\u6280\u672f\u7684siRNA\uff0c\u53ef\u589e\u5f3a\u7a33\u5b9a\u6027\u5e76\u6700\u5927\u7a0b\u5ea6\u5730\u964d\u4f4e\u8131\u9776\u6548\u5e94\uff0c\u4ece\u800c\u53ef\u63d0\u5347\u6cbb\u7597\u6548\u529b\u3002\u817e\u76db\u535a\u836f\u4e8e2020\u5e74\u4eceVir\u751f\u7269\u6280\u672f\u516c\u53f8\uff08\u201cVir\u201d\uff09\u83b7\u5f97\u4e86\u5728\u5927\u4e2d\u534e\u5730\u533a\u5f00\u53d1\u548c\u5546\u4e1a\u5316VIR-2218\u7684\u4e13\u6709\u6743\u3002<\/p>\n<p>\u540c\u65f6\uff0c\u4e09\u9879\u5206\u522b\u7531\u817e\u76db\u535a\u836f\u548c&nbsp;Vir \u7533\u529e\u7684\u4e8c\u671f\u7814\u7a76\u6b63\u5728\u5bf9BRII-835\uff08VIR-2218\uff09\u4f5c\u4e3a\u6162\u6027HBV\u611f\u67d3\u529f\u80fd\u6027\u6cbb\u6108\u65b9\u6848\u7684\u7ec4\u5408\u8fdb\u884c\u8bc4\u4f30\uff0c\u5305\u62ec\uff1aBRII-835\uff08VIR-2218\uff09&nbsp;\u4e0e&nbsp;BRII-179\uff08\u4e00\u79cd\u6cbb\u7597\u6027\u91cd\u7ec4\u86cb\u767d\u75ab\u82d7\uff09\uff0c\u805a\u4e59\u4e8c\u9187\u5316\u5e72\u6270\u7d20-\u03b1\uff08PEG-IFN-\u03b1\uff09\uff0c\u548c\/\u6216 VIR-3434 \uff08\u4e00\u79cd\u9488\u5bf9 HBV \u7684\u5355\u514b\u9686\u6297\u4f53\uff09\u7ec4\u5408\u3002<\/p>\n<p><b>\u5173\u4e8e\u4e59\u578b\u809d\u708e<\/b><\/p>\n<p>\u4e59\u578b\u809d\u708e\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u516c\u5171\u536b\u751f\u95ee\u9898\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6570\u8d85\u8fc72.9\u4ebf\uff0c\u6211\u56fd\u611f\u67d3\u4eba\u6570\u7ea6\u67097000\u591a\u4e07\u3002\u4e59\u809d\u75c5\u6bd2\u611f\u67d3\u662f\u809d\u810f\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u76ee\u524d\u7684\u6cbb\u7597\u65b9\u6cd5\u5f88\u96be\u5bf9\u5176\u8fdb\u884c\u6cbb\u6108\uff0c\u8bb8\u591a\u60a3\u8005\u4f1a\u7ee7\u53d1\u809d\u764c\u3002\u6bcf\u5e74\u7ea6\u670978\u4e07\u4eba\u6b7b\u4e8e\u6162\u6027\u4e59\u809d\u75c5\u6bd2\u611f\u67d3\u7684\u5e76\u53d1\u75c7\uff0c\u4f8b\u5982\u809d\u529f\u80fd\u5931\u4ee3\u507f\u4e0e\u809d\u7ec6\u80de\u764c\u3002<\/p>\n<p><b>\u5173\u4e8e\u817e\u76db\u535a\u836f<\/b><\/p>\n<p>\u817e\u76db\u535a\u836f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u201c\u817e\u76db\u535a\u836f\u201d\uff1b\u80a1\u4efd\u4ee3\u53f7\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u4f4d\u4e8e\u4e2d\u56fd\u53ca\u7f8e\u56fd\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u9488\u5bf9\u4e2d\u56fd\u53ca\u5168\u7403\u91cd\u5927\u611f\u67d3\u6027\u75be\u75c5\uff08\u5982\u4e59\u578b\u809d\u708e\u3001COVID-19\u3001\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2&nbsp;(HIV) \u611f\u67d3\u3001\u591a\u91cd\u8010\u836f&nbsp;(MDR) \u6216\u5e7f\u6cdb\u8010\u836f\u6027&nbsp;(XDR) \u9769\u5170\u6c0f\u9634\u6027\u83cc\u611f\u67d3\uff09\u53ca\u5176\u5b83\u5177\u6709\u91cd\u5927\u516c\u5171\u536b\u751f\u8d1f\u62c5\u7684\u75be\u75c5\uff08\u5982\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf&nbsp;(CNS) \u75be\u75c5\uff09\u5f00\u53d1\u521b\u65b0\u7597\u6cd5\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a target=\"_blank\" href=\"https:\/\/cn.briibio.com\/index.php\" rel=\"nofollow noopener\">www.briibio.com<\/a>\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder2\">  <\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u65b0\u6570\u636e\u8868\u660e\uff0cBRII-835\uff08VIR-2218\uff09\u5728\u4e2d\u56fd\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u4e14\u8840\u6e05HBsAg\u6c34\u5e73\u660e\u663e\u964d\u4f4e \u5317\u4eac\u548c\u5317\u5361\u7f57\u83b1\u7eb3\u5dde\u8fbe\u52d2\u59c6\u5e022022\u5e743\u670831\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u817e\u76db\u535a\u836f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8Brii Biosciences Limited\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u817e\u76db\u535a\u836f\u201d\u6216\u201c\u516c\u53f8\u201d\uff0c\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u9488\u5bf9\u60a3\u8005\u672a\u88ab\u6ee1\u8db3\u7684\u9700\u6c42\u53ca\u91cd\u5927\u516c\u5171\u536b\u751f\u75be\u75c5\u5f00\u53d1\u521b\u65b0\u7597\u6cd5\u7684\u8de8\u56fd\u4f01\u4e1a\uff0c\u4eca\u65e5\u57282022\u5e74\u4e9a\u592a\u809d\u810f\u7814\u7a76\u5b66\u4f1a\u7b2c&nbsp;31 \u5c4a\u4f1a\u8bae\uff08APASL\uff09\u4e0a\uff0c\u516c\u5e03\u4e86\u5176\u4e34\u5e8a\u9636\u6bb5\u5c0f\u5e72\u6270\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09BRII-835\uff08VIR-2218\uff09\u5728\u4e2d\u56fd\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u4e00\u9879\u4e8c\u671f\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\u7684\u6700\u65b0\u6570\u636e\uff0c\u8be5\u4f1a\u8bae\u4e8e3 \u6708 30 \u65e5\u81f3 4 \u6708 3 \u65e5\u671f\u95f4\u901a\u8fc7\u5728\u7ebf\u5f62\u5f0f\u5728\u97e9\u56fd\u9996\u5c14\u4e3e\u884c\u3002 \u6570\u636e\u663e\u793a\uff0c\u5728\u63a5\u53d7\u4e24\u6b21BRII-835\uff08VIR-2218\uff09\u7ed9\u836f\u540e\uff0c\u4e2d\u56fd\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u7684HBV\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6c34\u5e73\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u964d\u4f4e\uff0c\u5e76\u4e14\u5728HBeAg\u9634\u6027\u548cHBeAg\u9633\u6027\u60a3\u8005\u4e2dHBsAg\u6c34\u5e73\u964d\u4f4e\u7a0b\u5ea6\u76f8\u8fd1\u3002\u6b64\u5916\uff0cBRII-835\uff08VIR-2218\uff09\u8010\u53d7\u6027\u826f\u597d\uff0c\u6240\u6709\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\u5747\u4e3a\u8f7b\u6216\u4e2d\u5ea6\uff0c\u672a\u89c2\u5bdf\u5230\u5177\u6709\u663e\u8457\u4e34\u5e8a\u610f\u4e49\u7684\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08ALT\uff09\u5347\u9ad8\u3002 \u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u53cb\u8c0a\u533b\u9662\u809d\u75c5\u7814\u7a76\u4e2d\u5fc3\u8d3e\u7ee7\u4e1c\u6559\u6388\u8868\u793a\uff1a\u201c\u5728\u672c\u7814\u7a76\u4e2d\uff0cBRII-835\uff08VIR-2218\uff09\u4e24\u6b21\u7ed9\u836f\u540e\uff0cHBeAg\u9634\u6027\u548cHBeAg\u9633\u6027\u4e2d\u56fd\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u7684\u8840\u6e05HBsAg\u6c34\u5e73\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u964d\u4f4e\uff0c\u8fd9\u4e0e\u4e4b\u524d\u5728\u5176\u4ed6\u4eba\u79cd\/\u79cd\u65cf\u4e2d\u7684\u7814\u7a76\u7ed3\u679c\u4e00\u81f4\u3002\u5728\u8fd9\u4e9b\u6570\u636e\u7684\u652f\u6301\u4e0b\uff0c\u6211\u4eec\u8ba4\u4e3aBRII-835\uff08VIR-2218\uff09\u8fd9\u7c7b\u53ef\u964d\u4f4e\u7531\u6162\u6027HBV\u611f\u67d3\u5f15\u8d77\u7684\u9ad8\u75c5\u6bd2\u6297\u539f\u8d1f\u8377\u7684\u65b0\u578b\u836f\u7269\uff0c\u6709\u6f5c\u529b\u6210\u4e3a\u6162\u6027HBV\u529f\u80fd\u6027\u6cbb\u6108\u65b9\u6848\u7684\u57fa\u77f3\uff0c\u4ece\u800c\u6709\u52a9\u89e3\u51b3\u6162\u6027HBV\u611f\u67d3\u6240\u5e26\u6765\u7684\u5168\u7403\u6027\u91cd\u5927\u516c\u5171\u536b\u751f\u95ee\u9898\u3002\u201d 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\u7597\u6cd5BRII-835\uff08VIR-2218\uff09\u5728\u4e2d\u56fd\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u4e2d\u4e24\u6b21\u7ed9\u836f\uff08\u95f4\u9694\u4e00\u6708\uff09\u7684\u5b89\u5168\u6027\u548c\u6297\u75c5\u6bd2\u6d3b\u6027 \u4e3b\u8bb2\u4eba\uff1a\u8d3e\u7ee7\u4e1c\u6559\u6388\uff0cMD, Ph.D.\uff0c\u9996\u90fd\u533b\u79d1\u5927\u5b66\u533b\u5b66\u6559\u6388\uff0c\u5317\u4eac\u53cb\u8c0a\u533b\u9662\u809d\u75c5\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb \u572816\u4f8b\u8fbe\u5230\u75c5\u6bd2\u5b66\u6291\u5236\u7684\u4e2d\u56fd\u975e\u809d\u786c\u5316\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u4e2d\uff0c\u63a5\u53d7\u4e24\u6b21\uff08\u95f4\u9694\u4e00\u6708\uff09\u76ae\u4e0b\u6ce8\u5c04BRII-835\uff08VIR-2218\uff09\u7ed9\u836f\uff0c\u663e\u793a\u51fa\u5176\u826f\u597d\u7684\u8010\u53d7\u6027 \u672b\u6b21\u7ed9\u836f\u540e12\u5468\u65f6\uff0c\u5728\u63a5\u53d750 mg\u548c100 mg\u5242\u91cfBRII-835\uff08VIR-2218\uff09\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u5e73\u5747HBsAg\u964d\u5e45\u5206\u522b\u4e3a\uff1aHBeAg\u9634\u6027\u60a3\u8005\u4e3a1.02 log10 IU\/mL\u548c1.22 log10 IU\/mL\uff0cHBeAg\u9633\u6027\u60a3\u8005\u4e3a0.70 log10 IU\/mL\u548c1.15 log10 IU\/mL \u672b\u6b21\u7ed9\u836f\u540e12\u5468HBsAg\u6c34\u5e73\u964d\u4f4e&gt;1 log10 IU\/mL\u7684\u6240\u6709\u60a3\u8005\uff0c\u8840\u6e05HBsAg\u6c34\u5e73\u81f3\u7b2c48\u5468\u59cb\u7ec8\u4f4e\u4e8e\u57fa\u7ebf\u6c34\u5e73 \u5173\u4e8eBRII-835\uff08VIR-2218\uff09 BRII-835\uff08VIR-2218\uff09\u662f\u4e00\u79cd\u7ecf\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\u7684\u9776\u5411HBV\u7684siRNA\u7814\u7a76\u6027\u836f\u7269\uff0c\u5176\u4ecb\u5bfcRNA\u5e72\u6270\uff08RNAi\uff09\uff0c\u5177\u6709\u5bf9HBV\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u548c\u8bf1\u5bfc\u6709\u6548\u514d\u75ab\u5e94\u7b54\u7684\u6f5c\u529b\u3002\u5b83\u662f\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u7684\u91c7\u7528\u589e\u5f3a\u578b\u7a33\u5b9a\u5316\u5b66+\uff08ESC+\uff09\u6280\u672f\u7684siRNA\uff0c\u53ef\u589e\u5f3a\u7a33\u5b9a\u6027\u5e76\u6700\u5927\u7a0b\u5ea6\u5730\u964d\u4f4e\u8131\u9776\u6548\u5e94\uff0c\u4ece\u800c\u53ef\u63d0\u5347\u6cbb\u7597\u6548\u529b\u3002\u817e\u76db\u535a\u836f\u4e8e2020\u5e74\u4eceVir\u751f\u7269\u6280\u672f\u516c\u53f8\uff08\u201cVir\u201d\uff09\u83b7\u5f97\u4e86\u5728\u5927\u4e2d\u534e\u5730\u533a\u5f00\u53d1\u548c\u5546\u4e1a\u5316VIR-2218\u7684\u4e13\u6709\u6743\u3002 \u540c\u65f6\uff0c\u4e09\u9879\u5206\u522b\u7531\u817e\u76db\u535a\u836f\u548c&nbsp;Vir \u7533\u529e\u7684\u4e8c\u671f\u7814\u7a76\u6b63\u5728\u5bf9BRII-835\uff08VIR-2218\uff09\u4f5c\u4e3a\u6162\u6027HBV\u611f\u67d3\u529f\u80fd\u6027\u6cbb\u6108\u65b9\u6848\u7684\u7ec4\u5408\u8fdb\u884c\u8bc4\u4f30\uff0c\u5305\u62ec\uff1aBRII-835\uff08VIR-2218\uff09&nbsp;\u4e0e&nbsp;BRII-179\uff08\u4e00\u79cd\u6cbb\u7597\u6027\u91cd\u7ec4\u86cb\u767d\u75ab\u82d7\uff09\uff0c\u805a\u4e59\u4e8c\u9187\u5316\u5e72\u6270\u7d20-\u03b1\uff08PEG-IFN-\u03b1\uff09\uff0c\u548c\/\u6216 VIR-3434 \uff08\u4e00\u79cd\u9488\u5bf9 HBV \u7684\u5355\u514b\u9686\u6297\u4f53\uff09\u7ec4\u5408\u3002 \u5173\u4e8e\u4e59\u578b\u809d\u708e \u4e59\u578b\u809d\u708e\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u516c\u5171\u536b\u751f\u95ee\u9898\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6570\u8d85\u8fc72.9\u4ebf\uff0c\u6211\u56fd\u611f\u67d3\u4eba\u6570\u7ea6\u67097000\u591a\u4e07\u3002\u4e59\u809d\u75c5\u6bd2\u611f\u67d3\u662f\u809d\u810f\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u76ee\u524d\u7684\u6cbb\u7597\u65b9\u6cd5\u5f88\u96be\u5bf9\u5176\u8fdb\u884c\u6cbb\u6108\uff0c\u8bb8\u591a\u60a3\u8005\u4f1a\u7ee7\u53d1\u809d\u764c\u3002\u6bcf\u5e74\u7ea6\u670978\u4e07\u4eba\u6b7b\u4e8e\u6162\u6027\u4e59\u809d\u75c5\u6bd2\u611f\u67d3\u7684\u5e76\u53d1\u75c7\uff0c\u4f8b\u5982\u809d\u529f\u80fd\u5931\u4ee3\u507f\u4e0e\u809d\u7ec6\u80de\u764c\u3002 \u5173\u4e8e\u817e\u76db\u535a\u836f 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