{"id":66221,"date":"2022-03-30T07:00:00","date_gmt":"2022-03-30T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022033007000066221"},"modified":"2022-03-30T18:14:22","modified_gmt":"2022-03-30T10:14:22","slug":"%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%85%ac%e5%b8%832021%e5%b9%b4%e5%85%a8%e5%b9%b4%e4%b8%9a%e7%bb%a9%e5%8f%8a%e5%85%ac%e5%8f%b8%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022033007000066221","title":{"rendered":"\u4fe1\u8fbe\u751f\u7269\u516c\u5e032021\u5e74\u5168\u5e74\u4e1a\u7ee9\u53ca\u516c\u53f8\u8fdb\u5c55"},"content":{"rendered":"<p><p><span class=\"xn-subheadline\">\u4ea7\u54c1\u6536\u5165\u783440\u4ebf\uff0c\u8fc8\u5165\u540e\u671f\u7ba1\u7ebf\u6536\u83b7\u671f\uff0c32\u6761\u9ad8\u4ef7\u503c\u4ea7\u54c1\u7ba1\u7ebf\u84c4\u52bf\u5f85\u53d1<\/span><\/p>\n<p>\u7f8e\u56fd\u65e7\u91d1\u5c71\u548c\u4e2d\u56fd\u82cf\u5dde2022\u5e743\u670829\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u516c\u5e03\u4e862021\u5e74\u5ea6\u4e1a\u7ee9\u548c\u516c\u53f8\u8fdb\u5c55\u3002<\/p>\n<p>\u4fe1\u8fbe\u751f\u7269\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517cCEO\u4fde\u5fb7\u8d85\u535a\u58eb\u8868\u793a\uff1a\u201c2021\u5e74\u662f\u4fe1\u8fbe\u6210\u7acb\u7684\u7b2c\u5341\u5e74\uff0c\u5341\u5e74\u6765\u6211\u4eec\u575a\u6301\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\u7684\u4f7f\u547d\uff0c\u6210\u957f\u4e3a\u4e00\u5bb6\u4e2d\u56fd\u9886\u5148\u7684\u62e5\u6709\u6210\u719f\u5e73\u53f0\u80fd\u529b\u3001\u5f3a\u5927\u7684\u6267\u884c\u529b\u548c\u826f\u597d\u7684\u8d22\u52a1\u8fd0\u8425\u72b6\u51b5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u8fc7\u53bb\u4e00\u5e74\uff0c\u6211\u4eec\u575a\u5b9a\u5730\u6267\u884c\u516c\u53f8\u521b\u65b0\u548c\u5168\u7403\u5316\u53d1\u5c55\u7684\u6218\u7565\uff0c\u5728\u521b\u65b0\u7814\u53d1\u3001\u5546\u4e1a\u89c4\u5212\u3001\u4ea7\u80fd\u5efa\u8bbe\u3001\u5168\u7403\u5e03\u5c40\u548c\u6218\u7565\u5408\u4f5c\u591a\u65b9\u9762\u6301\u7eed\u53d6\u5f97\u91cd\u8981\u8fdb\u5c55\u3002\u516c\u53f8\u642d\u5efa\u4e86\u4e00\u6761\u62e5\u670932\u6b3e\u5904\u4e8e\u4e34\u5e8a\u4e0d\u540c\u9636\u6bb5\u4ea7\u54c1\u7684\u9ad8\u4ef7\u503c\u7ba1\u7ebf\uff0c\u672a\u6765\u4e24\u5e74\u83b7\u6279\u4ea7\u54c1\u5c06\u6269\u5145\u81f3\u5341\u6b3e\u4ee5\u4e0a\uff0c\u6210\u719f\u5b8c\u5907\u7684\u5546\u4e1a\u5316\u5e73\u53f0\u548c\u961f\u4f0d\u4ee5\u53ca\u517c\u5177\u6210\u672c\u4f18\u52bf\u548c\u8fd0\u8425\u6548\u7387\u7684\u9ad8\u8d28\u91cf\u5927\u89c4\u6a21\u4ea7\u80fd\u4fdd\u8bc1\u4e86\u4e1a\u52a1\u7684\u5f3a\u52b2\u589e\u957f\u3002\u6211\u4eec\u5efa\u7acb\u4e86\u5168\u7403\u521b\u65b0\u7684\u7814\u53d1\u3001<span id=\"spanHghlte00a\">\u4e34\u5e8a\u7814\u7a76<\/span>\u548c\u6ce8\u518c\u56e2\u961f\u53ca\u4f53\u7cfb\uff0c\u5341\u591a\u6b3e\u5177\u6709\u5168\u7403\u6f5c\u529b\u7684\u521b\u65b0\u7ba1\u7ebf\u6b63\u5904\u4e8e\u4e34\u5e8a\u63a2\u7d22\u9636\u6bb5\u30022022\u5e74\u662f\u4fe1\u8fbe\u751f\u7269\u65b0\u5341\u5e74\u7684\u5f00\u7aef\uff0c\u5728\u65b0\u7684\u8d77\u70b9\u4e0a\u6211\u4eec\u5c06\u4ee5\u521b\u65b0\u4e3a\u57fa\u77f3\uff0c\u8d70\u5168\u7403\u5316\u9053\u8def\uff0c\u81f4\u529b\u4e8e\u6210\u4e3a\u4e00\u5bb6\u56fd\u9645\u4e00\u6d41\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e3a\u60a3\u8005\u3001\u5458\u5de5\u3001\u80a1\u4e1c\u548c\u793e\u4f1a\u4e0d\u65ad\u521b\u9020\u4ef7\u503c\uff0c\u5b9e\u73b0\u516c\u53f8\u7684\u957f\u671f\u53ef\u6301\u7eed\u53d1\u5c55\u3002\u201d<\/p>\n<p><b>\u4e1a\u7ee9\u4eae\u70b9<\/b><b>&nbsp;<\/b><b>\u4e00\u7779\u4e3a\u5148<\/b><\/p>\n<ul type=\"disc\">\n<li>2021\u5e74\u5168\u5e74\uff0c\u516c\u53f8\u5b9e\u73b0\u603b\u6536\u516542.61\u4ebf\uff0c\u4ea7\u54c1\u6536\u516540.01\u4ebf\u4eba\u6c11\u5e01\uff0c<span id=\"spanHghltef0f\">\u4ea7\u54c1\u6536\u5165<\/span>\u540c\u6bd4\u589e\u957f69.0%\uff1b <\/li>\n<li>\u6269\u5145\u5546\u4e1a\u5316\u7248\u56fe\u81f3\u516d\u4e2a\u4e0a\u5e02\u4ea7\u54c1(\u4e24\u4e2a\u65b0\u83b7\u6279)\uff1b\u4e0e\u793c\u6765\u62d3\u5c55\u6218\u7565\u5408\u4f5c\uff0c\u518d\u83b7\u7b2c\u4e03\u4e2a\u83b7\u6279\u4ea7\u54c1\u53ca\u4e00\u6b3e\u4e34\u8fd1\u5546\u4e1a\u5316\u4ea7\u54c1\uff1b <\/li>\n<li>\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\u65b0\u589e\u4e09\u9879\u5927\u7624\u79cd\u4e00\u7ebf\u9002\u5e94\u75c7\u83b7\u6279\u5e76\u6210\u529f\u8fdb\u5165\u533b\u4fdd\u76ee\u5f55\uff0c\u4e5f\u662f\u552f\u4e00\u62e5\u6709\u4e94\u5927\u9002\u5e94\u75c7\u9633\u6027\u7ed3\u679c\u7684PD-1\u6291\u5236\u5242\uff1b <\/li>\n<li>\u516d\u4e2a\u5206\u5b50\u5904\u4e8eNDA\u6216<span id=\"spanHghltb145\">\u4e34\u5e8a\u7814\u7a76\u540e\u671f\uff1b<\/span> <\/li>\n<li>\u4e03\u4e2a\u5206\u5b50\u53d6\u5f97\u79ef\u6781\u6982\u5ff5\u9a8c\u8bc1\uff08PoC\uff09\u6570\u636e\uff1b <\/li>\n<li>\u5168\u7403\u5316\u521b\u65b0\u5e03\u5c40\u52a0\u901f\uff0cFIC\u9776\u70b9\u52a0\u901f\u63a2\u7d22\u3001\u5168\u7403\u7814\u53d1\u56e2\u961f\u6709\u5e8f\u6269\u5927\u3001\u5168\u7403\u5e73\u53f0\u4f53\u7cfb\u5efa\u7acb\uff1b <\/li>\n<li>\u8fd110\u9879\u6d77\u5185\u5916\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u6218\u7565\u5408\u4f5c\uff0c\u5145\u5206\u53d1\u6325\u5e73\u53f0\u4ef7\u503c\uff0c\u62d3\u5c55\u7ba1\u7ebf\u534f\u540c\u6548\u5e94\u3002<\/li>\n<\/ul>\n<p><b>\u4ea7\u54c1\u6536\u5165\u5feb\u901f\u589e\u957f<\/b><b>&nbsp;<\/b><b>\u5546\u4e1a\u5316\u5e73\u53f0\u4ef7\u503c\u518d\u83b7\u9a8c\u8bc1<\/b><\/p>\n<ul type=\"disc\">\n<li>\u516c\u53f8\u4ea7\u54c1\u6536\u5165\u8fbe40.01\u4ebf\u4eba\u6c11\u5e01\uff1a\u540c\u6bd4\u589e\u957f69.0%\uff1b <\/li>\n<li>\u81f32021\u5e74\u5e95\uff0c\u83b7\u6279\u54c1\u79cd\u589e\u52a0\u81f3\u516d\u6b3e\uff1a\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\u3001\u8fbe\u6538\u540c<sup>&reg;<\/sup>\u3001\u82cf\u7acb\u4fe1<sup>&reg;<\/sup>\u3001\u8fbe\u4f2f\u534e<sup>&reg;<\/sup>\u3001\u8fbe\u4f2f\u5766<sup>&reg;<\/sup>\u3001\u8010\u7acb\u514b<sup>&reg;<\/sup> \uff1b <\/li>\n<li>2022\u5e743\u6708\uff0c\u4e0e\u793c\u6765\u62d3\u5c55\u6218\u7565\u5408\u4f5c\uff0c\u5546\u4e1a\u5316\u80fd\u529b\u518d\u83b7\u8ba4\u53ef\uff1a\u83b7\u5f97\u7b2c\u4e03\u6b3e\u4e0a\u5e02\u54c1\u79cd\u5e0c\u5189\u62e9<sup>&reg;<\/sup>\uff08\u96f7\u83ab\u897f\u5c24\u5355\u6297\uff09\u548c\u4e00\u6b3eNDA\u9636\u6bb5\u54c1\u79cdRetsevmo<sup>&reg;<\/sup>\uff08\u585e\u666e\u66ff\u5c3c\uff09\u5728\u4e2d\u56fd\u5927\u9646\u7684\u72ec\u5bb6\u5546\u4e1a\u5316\u6743\u5229\uff0c\u53ca\u540e\u671f\u4e34\u5e8a\u7ba1\u7ebfPirtobrutinib\uff08BTK\u6291\u5236\u5242\uff09\u5728\u4e2d\u56fd\u5927\u9646\u7684\u72ec\u5bb6\u5546\u4e1a\u5316\u4f18\u5148\u8c08\u5224\u6743\uff1b <\/li>\n<li>\u5e7f\u9614\u7684\u6e20\u9053\u8986\u76d6\u548c\u4e13\u4e1a\u5316\u56e2\u961f\uff1a\u8d855,100\u5bb6\u533b\u9662\u548c1,100\u5bb6DTP\u836f\u623f\u8986\u76d6\uff0c\u8fd1<span id=\"spanHghlt4666\">3,000<\/span>\u4eba\u5546\u4e1a\u5316\u56e2\u961f\uff0c\u5546\u4e1a\u5316\u5e73\u53f0\u4ef7\u503c\u51f8\u663e\u3002<\/li>\n<\/ul>\n<p><b>32<\/b><b>\u4e2a\u521b\u65b0\u7ba1\u7ebf<\/b><b>&nbsp;<\/b><b>\u8fc8\u5165\u4ea7\u54c1\u4e0a\u5e02\u6301\u7eed\u6536\u83b7\u671f<\/b><\/p>\n<ul type=\"disc\">\n<li><b>PD-1<\/b><b>\u9886\u5148\u54c1\u724c\u8fbe\u4f2f\u8212<\/b><b><sup>&reg;<\/sup><\/b>\uff1a <\/li>\n<ul type=\"circle\">\n<li>\u65b0\u589e\u4e09\u9879\u5927\u7624\u79cd\u9002\u5e94\u75c7\u83b7\u6279\u5e76\u6210\u529f\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\uff08\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u809d\u764c\uff09\uff1b <\/li>\n<li>\u552f\u4e00\u5728\u5305\u62ec\u4e94\u9879\u9ad8\u53d1\u7624\u79cd\u7684\u4e00\u7ebf\u6cbb\u7597\u4e2d\u5747\u8bc1\u5b9e\u5176\u4e34\u5e8a\u7597\u6548\u7684PD-1\u6291\u5236\u5242\uff08\u4e00\u7ebf\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u4e00\u7ebf\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u4e00\u7ebf\u809d\u764c\u3001\u4e00\u7ebf\u98df\u7ba1\u764c\u548c\u4e00\u7ebf\u80c3\u764c\uff09\uff1b <\/li>\n<li>\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>&nbsp;\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u8363\u767b\u56fd\u9645\u533b\u5b66\u6742\u5fd7<i>\u67f3\u53f6\u5200\u5b50\u520a\u3001<\/i><i>ESMO Open<\/i><i>\u3001<\/i><i>BMJ<\/i>\u7b49\uff1b<\/li>\n<\/ul>\n<li><b>\u516d\u6b3e\u4ea7\u54c1\u5904\u4e8e<\/b><b>NDA<\/b><b>\u6216\u6ce8\u518c<\/b><b>\/<\/b><b>\u5173\u952e\u4e34\u5e8a\uff1a<\/b> <\/li>\n<ul type=\"circle\">\n<li>Retsevmo<sup>&reg;<\/sup>\uff08\u585e\u666e\u66ff\u5c3c\uff09\uff0c\u5df2\u9012\u4ea4NDA <\/li>\n<li>IBI-326 (BCMA CAR-T) \uff0c2022\u5e74\u9012\u4ea4NDA <\/li>\n<li>IBI-306 (PCSK9) \uff0c2022\u5e74\u9012\u4ea4NDA <\/li>\n<li>IBI-310 (CTLA-4) \uff0c2022\u5e74\u9012\u4ea4NDA <\/li>\n<li>IBI-344 (ROS1\/NTRK) \uff0c\u5173\u952e\u4e8c\u671f\u4e34\u5e8a\u8fdb\u884c\u4e2d <\/li>\n<li>IBI-376 (PI3K\u03b4) \uff0c\u5173\u952e\u4e8c\u671f\u4e34\u5e8a\u8fdb\u884c\u4e2d<sup>[1]<\/sup><\/li>\n<\/ul>\n<li><b>\u4e03\u6b3e\u521b\u65b0\u4ea7\u54c1\u7ba1\u7ebf\u53d6\u5f97\u79ef\u6781\u7684\u6982\u5ff5\u9a8c\u8bc1\uff08<\/b><b>PoC<\/b><b>\uff09\u6570\u636e\uff0c\u8ba1\u5212\u63a8\u8fdb\u540e\u671f\u4e34\u5e8a\uff1a<\/b> <\/li>\n<ul type=\"circle\">\n<li>IBI-188 (CD47)\uff1aMDS\u4e34\u5e8a1b\u671f\u521d\u6b65\u6570\u636e\u8bfb\u51fa\uff0c\u7597\u6548\u6027\u7a81\u51fa\uff08ORR 83.3%\uff09\uff0c\u5b89\u5168\u6027\u53ef\u63a7\u30022022\u5e74\u8fdb\u5165MDS 3\u671f\u4e34\u5e8a\uff1b <\/li>\n<li>IBI-362 (GLP-1\/GCGR) \uff1a\u80a5\u80d61b\u671f\u4e34\u5e8a\u663e\u793a\u51fa\u975e\u51e1\u51cf\u91cd\u6548\u679c\uff0c\u7814\u7a76\u7ed3\u679c\u8363\u767b\u67f3\u53f6\u5200\u5b50\u520a\uff1b\u964d\u7cd6\u6548\u679c\u7a81\u51fa\uff1b\u6709\u671b\u6210\u4e3a\u540c\u7c7b\u9996\u521b\uff08FIC\uff09\u548c\u540c\u7c7b\u6700\u4f73\uff08BIC\uff09\u65b0\u4e00\u4ee3\u53cc\u9776GLP-1\u6291\u5236\u5242\u30022022\u5e74\u8fdb\u5165\u80a5\u80d6\u53ca\u7cd6\u5c3f\u75c5\u53cc\u9879\u9002\u5e94\u75c7\u4e09\u671f\u4e34\u5e8a\uff1b&nbsp; <\/li>\n<li>IBI-326 (BCMA CAR-T)\uff1a\u4e34\u5e8a1\/2\u671f<span id=\"spanHghlt3ff3\">\u7814\u7a76<\/span>\u663e\u793a\u51fa\u4f18\u5f02\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u66f4\u957f\u7684\u4f53\u5185\u5b58\u7eed\u65f6\u95f4\uff0c\u53ca\u65e2\u5f80BCMA CAR-T\u590d\u53d1\u540e\u7684\u9ad8\u7597\u6548\uff0c2022\u5e74\u7533\u62a5NDA\uff1b <\/li>\n<li>IBI-310 (CTLA-4)\uff1a\u8054\u5408\u4fe1\u8fea\u4f8b\u5355\u6297\u6cbb\u7597\u5bab\u9888\u764c\u548c\u809d\u764c\u5747\u53d6\u5f97\u79ef\u6781PoC\u30022022\u5e74\u7533\u62a5\u5bab\u9888\u764cNDA\uff1b <\/li>\n<li>IBI-344 (ROS1\/NTRK)\uff1a\u5728\u65e2\u5f80\u63a5\u53d7\u8fc7\u6216\u672a\u63a5\u53d7\u8fc7\u514b\u5511\u66ff\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u4e2dORR% \u9ad8\u8fbe90.5% \u548c&nbsp;43.8%\u3002\u83b7NMPA\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u8bc1\u30022022\u5e74\u7ee7\u7eed\u5173\u952e\u4e34\u5e8a2\u671f\uff1b <\/li>\n<li>IBI-302 (VEGF\/C)\uff1a1b\u671f\u4e34\u5e8a<span id=\"spanHghlt3ff3\">\u7814\u7a76<\/span>\u663e\u793a\u89c6\u529b\u53ca\u9ec4\u6591\u6c34\u80bf\u6539\u5584\uff0c\u9ec4\u6591\u53d8\u60272\u671f\u4e34\u5e8a<span id=\"spanHghlt3ff3\">\u7814\u7a76<\/span>\u8fdb\u884c\u4e2d\uff1b <\/li>\n<li>IBI-112 (IL-23p19)\uff1a\u94f6\u5c51\u75c52\u671f\u4e34\u5e8a\u6548\u679c\u7a81\u51fa\uff0c\u56fd\u5185\u8fdb\u5c55\u6700\u5feb\u4e14\u5177\u6709\u66f4\u957f\u6548\u6f5c\u529b\u7684IL-23\u6297\u4f53\u30022022\u5e74\u8fdb\u5165\u94f6\u5c51\u75c53\u671f\u4e34\u5e8a<span id=\"spanHghlt3ff3\">\u7814\u7a76\uff1b<\/span><\/li>\n<\/ul>\n<li><b>\u52a0\u901f\u5f00\u5c55\u591a\u6b3e\u5168\u7403\u6f5c\u529b\u7ba1\u7ebf\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u9646\u7eed\u8bfb\u51fa<span id=\"spanHghltbc2c\">\u4e34\u5e8a\u7814\u7a76<\/span>\u6982\u5ff5\u9a8c\u8bc1\uff08<\/b><b>PoC<\/b><b>\uff09\u6570\u636e<\/b><b>&nbsp;<\/b> <\/li>\n<ul type=\"circle\">\n<li><b>CD47<\/b><b>\u5bb6\u65cf\uff1a<\/b>IBI-188 (CD47), IBI-322 (PD-L1\/CD47), IBI-397 (SIRP\u03b1) <\/li>\n<li><b>LAG-3<\/b><b>\u5bb6\u65cf\uff1a<\/b>IBI-110 (LAG-3), IBI-323 (PD-L1\/LAG-3) <\/li>\n<li><b>TIGIT<\/b><b>\u5bb6\u65cf\uff1a<\/b>IBI-939 (TIGIT), IBI-321 (PD-1\/TIGIT) <\/li>\n<li><b>VEGF<\/b><b>\u5bb6\u65cf\uff1a<\/b>IBI-302 (VEGF\/C), IBI-324 (<span id=\"spanHghlte3e3\">VEGF\/<\/span>ANG-2), IBI-333 (VEGF-A\/VEGF-C)<\/li>\n<\/ul>\n<\/ul>\n<p><b>\u5347\u7ea7\u5168\u7403\u5316\u521b\u65b0\u5e73\u53f0\u4e0e\u4f53\u7cfb<\/b><\/p>\n<ul type=\"disc\">\n<li><b>\u7f8e\u56fd\u7814\u53d1\u4e2d\u5fc3\uff08<\/b><b>Innovent US <span id=\"spanHghlte253\">Labs<\/span><\/b><b>\uff09\u6b63\u5f0f\u843d\u6210<\/b>\uff1a\u4e13\u6ce8\u5168\u7403\u521b\u65b0\uff0c\u6253\u9020\u524d\u6cbf\u65b0\u9776\u70b9\u53ca\u6280\u672f\u5e73\u53f0\uff0c\u52a0\u901f\u79d1\u5b66\u6210\u679c\u8f6c\u5316\u843d\u5730\uff1b <\/li>\n<li><b>\u79d1\u5b66\u987e\u95ee\u59d4\u5458\u4f1a\uff08<\/b><b>SAB<\/b><b>\uff09\u6210\u7acb<\/b>\uff1a\u80bf\u7624\u5b66\u548c\u751f\u547d\u79d1\u5b66\u9886\u57df\u9876\u5c16\u4e13\u5bb6\u52a0\u5165\uff0c\u5e26\u6765\u4e13\u4e1a\u524d\u6cbf\u7684\u5b66\u672f\u7814\u7a76\u7406\u5ff5\u3001\u4e3a\u65e9\u671f\u836f\u7269\u53d1\u73b0\u53ca\u4e34\u5e8a\u5f00\u53d1\u63d0\u4f9b\u79d1\u5b66\u5efa\u8bae\uff1b <\/li>\n<li><b>CMC<\/b><b>\u987e\u95ee\u59d4\u5458\u4f1a\u6210\u7acb\uff1a<\/b>\u4e3aCMC\u677f\u5757\u7684\u6218\u7565\u548c\u7ec4\u7ec7\u4f18\u5316\u65b9\u6848\u53ca\u677f\u5757\u6295\u8d44\u8fdb\u884c\u5ba1\u67e5\u5e76\u63d0\u4f9b\u4e13\u4e1a\u5efa\u8bae\uff0c\u4ee5\u4fdd\u969c\u4fe1\u8fbe\u751f\u7269CMC\u677f\u5757\u66f4\u6709\u6548\u5730\u843d\u5b9e\u6218\u7565\uff1b <\/li>\n<li><b>\u6d77\u5916\u7814\u53d1\u56e2\u961f\u5feb\u901f\u6269\u5f20\uff0c\u6253\u9020\u5b8c\u5907\u5168\u7403\u5f00\u53d1\u5e73\u53f0\u4f53\u7cfb\uff1a<\/b>\u5df2\u642d\u5efa\u8fd1\u767e\u4eba\u6d77\u5916\u7814\u53d1\u56e2\u961f\u5e76\u521d\u6b65\u5efa\u7acb\u5b8c\u5907\u6d77\u5916\u5f00\u53d1\u6ce8\u518c\u4f53\u7cfb\uff1b\u6d77\u5916\u56e2\u961f\u5feb\u901f\u6269\u5f20\uff0c\u52a0\u901f\u7ba1\u7ebf\u5168\u7403\u5f00\u53d1\u3002 <\/li>\n<li><b>\u5e03\u5c40\u591a\u9879\u5168\u7403\u521b\u65b0\u6280\u672f\u5e73\u53f0\u7684\u5f00\u53d1\u5408\u4f5c\uff1a<\/b> <\/li>\n<ul type=\"circle\">\n<li>\u4e0eSynaffix\u5408\u4f5c\u5f00\u53d1ADC\u5019\u9009\u5206\u5b50 <\/li>\n<li>\u4e0eBOLT Therapeutics\u5408\u4f5c\u5f00\u53d1\u6297\u4f53-\u514d\u75ab\u523a\u6fc0\u5076\u8054\u7269\uff08ISAC\uff09\u5019\u9009\u836f\u7269 <\/li>\n<li>\u4e0eAmagma Therapeutics\u5408\u4f5c\u5f00\u53d1\u9176\u7279\u5f02\u6027\u6297\u4f53\u836f\u7269 <\/li>\n<li>\u5c06\u5168\u4eba\u6e90&nbsp;BCMA CAR \u7ed3\u6784\u6388\u4e88SANA Biotechnology\u7528\u4e8e\u7279\u5b9a\u7684\u4f53\u5185\u57fa\u56e0\u6cbb\u7597\u548c\u4f53\u5916\u4f4e\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u5f00\u53d1<\/li>\n<\/ul>\n<\/ul>\n<p><b>\u91cd\u78c5\u6d77\u5185\u5916\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u5408\u4f5c<\/b><b>&nbsp;<\/b><b>\u643a\u624b\u5171\u8d62<\/b><\/p>\n<ul type=\"disc\">\n<li><b>\u8fbe\u6210\u591a\u9879\u91cd\u8981\u7ba1\u7ebf\u7684\u5171\u540c\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u5408\u4f5c\uff1a<\/b> <\/li>\n<ul type=\"circle\">\n<li>\u4e0e\u793c\u6765\u5236\u836f\u8fdb\u4e00\u6b65\u6df1\u5316\u6218\u7565\u5408\u4f5c\uff0c\u83b7\u5f97\u5e0c\u5189\u62e9<sup>&reg;<\/sup>\uff08\u96f7\u83ab\u897f\u5c24\u5355\u6297\uff09\u548cRetsevmo<sup>&reg;<\/sup>\uff08\u585e\u666e\u66ff\u5c3c\uff09\u5728\u4e2d\u56fd\u5927\u9646\u7684\u72ec\u5bb6\u5546\u4e1a\u5316\u6743\u5229\uff0c\u4ee5\u53capirtobrutinib\u672a\u6765\u5728\u4e2d\u56fd\u5927\u9646\u5546\u4e1a\u5316\u6743\u5229\u7684\u4f18\u5148\u8c08\u5224\u6743\uff1b <\/li>\n<li>\u4e0e\u8446\u5143\u533b\u836f\u8fbe\u6210\u5408\u4f5c\uff0c\u5728\u5927\u4e2d\u534e\u533a\u5171\u540c\u5f00\u53d1\u548c\u5546\u4e1a\u5316taletrectinib\uff08ROS1\/NTRK\u6291\u5236\u5242\uff09\uff1b <\/li>\n<li>\u4e0e\u4e9a\u76db\u533b\u836f\u8fbe\u6210\u5408\u4f5c\uff0c\u5171\u540c\u8fdb\u884colverembatinib\uff08BCR-ABL\u6291\u5236\u5242\uff09\u7684\u5546\u4e1a\u63a8\u5e7f\u53ca\u5176\u5b83\u5408\u4f5c\uff1b <\/li>\n<li>\u4e0e\u52b2\u65b9\u533b\u836f\u8fbe\u6210\u5408\u4f5c\uff0c\u83b7\u5f97GFH925\uff08KRAS G12C\u6291\u5236\u5242\uff09\u7684\u4e2d\u56fd\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u76ca\u53ca\u5168\u7403\u6743\u76ca\u9009\u62e9\u6743\uff1b <\/li>\n<li>\u4e0eUNION\u7b7e\u8ba2\u5408\u4f5c\uff0c\u83b7\u5f97orismilast\uff08PDE4\u6291\u5236\u5242\uff09\u5728\u4e2d\u56fd\u7814\u53d1\u548c\u5546\u4e1a\u5316\u7684\u72ec\u5bb6\u6743\u76ca\u3002<\/li>\n<\/ul>\n<\/ul>\n<p><b>\u9ad8\u8d28\u91cf\u89c4\u6a21\u5316\u751f\u4ea7<\/b><b>&nbsp;<\/b><b>\u7115\u65b0\u5347\u7ea7<\/b><\/p>\n<ul type=\"disc\">\n<li>\u65b0\u751f\u4ea7\u8bbe\u65bd\u843d\u6210\uff1a\u4ea7\u80fd\u6210\u529f\u4ece24000\u5347\u6269\u5927\u523060000\u5347\uff0c\u62e5\u6709\u56fd\u5185\u6700\u5927\u89c4\u6a21\u4e4b\u4e00\u7684\u4e0d\u9508\u94a2\u751f\u4ea7\u4ea7\u80fd\uff1b <\/li>\n<li>\u751f\u4ea7\u7b26\u5408GMP\u8981\u6c42\uff0c\u5927\u89c4\u6a21\u4e0d\u9508\u94a2\u751f\u4ea7\u6210\u672c\u4f18\u52bf\u660e\u663e\u3002<\/li>\n<\/ul>\n<p><b>\u8d22\u52a1\u56de\u987e<\/b><b>&nbsp;<\/b><b>\u52a0\u901f\u53d1\u5c55<\/b><\/p>\n<ul type=\"disc\">\n<li>\u603b\u6536\u516542.61\u4ebf\u4eba\u6c11\u5e01\uff0c\u4ea7\u54c1\u6536\u516540.01\u4ebf\u4eba\u6c11\u5e01\uff0c\u540c\u6bd4\u589e\u957f69.0%\uff1b <\/li>\n<li>\u4ea7\u54c1\u6bdb\u5229\u738788.6%\uff0c\u540c\u6bd4\u4e0a\u53473.7%\uff1b <\/li>\n<li>\u7814\u53d1\u6295\u516521.16\u4ebf\u4eba\u6c11\u5e01\uff0c\u540c\u6bd4\u589e\u957f23.2%\uff1b <\/li>\n<li>\u51c0\u4e8f\u635f22.43\u4ebf<span id=\"spanHghltc240\">\u4eba\u6c11\u5e01\uff1b<\/span> <\/li>\n<li>\u622a\u6b622021\u5e74\u5e95\uff0c\u62e5\u6709\u73b0\u91d1\u7ea614.15\u4ebf\u7f8e\u5143\uff0c\u4e3a\u516c\u53f8\u6301\u7eed\u4e13\u6ce8\u4e8e\u957f\u671f\u53d1\u5c55\u63d0\u4f9b\u575a\u5b9e\u4fdd\u969c<sup><span id=\"spanHghlt830f\">[2]&nbsp;<\/span><\/sup><\/li>\n<\/ul>\n<div>\n<table id=\"convertedTable8d96\" cellspacing=\"0\" cellpadding=\"0\" border=\"0\" class=\"prnsbt0 prnsbr0 prnbcc prnsbb0 prnsbl0\">\n<tbody>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><i><sup>[1].<\/sup><\/i><i>&nbsp;<\/i><i>2022<\/i><i>\u5e74<\/i><i>1<\/i><i>\u6708\uff0c<\/i><i>Incyte<\/i><i>\u51b3\u5b9a\u64a4\u56de<\/i><i>PI3K<\/i><i>\u03b4\u6291\u5236\u5242<\/i><i>parsaclisib<\/i><i>\u5728\u7f8e\u56fd\u7684<\/i><i>FL<\/i><i>\u3001<\/i><i>MZL<\/i><i>\u548c<\/i><i>MCL<\/i><i>\u7684<\/i><i>NDA<\/i><i>\u7533\u8bf7\u3002\u64a4\u56de\u662f\u4e00\u9879\u5546\u4e1a\u51b3\u5b9a\uff0c\u4e0e<\/i><i>parsaclisib<\/i><i>\u7684\u7597\u6548\u6216\u5b89\u5168\u6027\u65e0\u5173\u3002\u516c\u53f8\u62e5\u6709<\/i><i>parsaclisib<\/i><i>\u7684\u4e2d\u56fd\u6743\u76ca\u3002\u516c\u53f8\u8ba1\u5212\u4e0e<\/i><i>&nbsp;NMPA <\/i><i>\u8fdb\u884c<\/i><i>\u6c9f\u901a\uff0c\u8ba8\u8bba\u5728\u4e2d\u56fd\u7684\u6f5c\u5728\u7533\u62a5\u8ba1\u5212\u3002<\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><i><sup>[2].<\/sup> <\/i><i>\u672c\u6587\u4e2d\u63d0\u53ca\u7684\u8d22\u52a1\u6570\u636e\u91c7\u7528\u4e86\u975e\u56fd\u9645\u8d22\u52a1\u62a5\u544a\u51c6\u5219\u8ba1\u91cf\uff0c\u53bb\u9664\u82e5\u5e72\u975e\u73b0\u91d1\u9879\u76ee\u53ca\u975e\u7ecf\u5e38\u6027\u4e8b\u4ef6\u5e26\u6765\u7684\u5f71\u54cd\u3002\u8be6\u60c5\u8bf7\u53c2\u9605\u96c6\u56e2\u4e1a\u7ee9\u516c\u544a\u3002<\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p><b>\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n<p>\u201c\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c\u201d\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u7406\u60f3\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u75be\u75c5\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u30022018\u5e7410\u670831\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a01801\u3002<\/p>\n<p>\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u516c\u53f8\u51ed\u501f\u521b\u65b0\u6210\u679c\u548c\u56fd\u9645\u5316\u7684\u8fd0\u8425\u6a21\u5f0f\u5728\u4f17\u591a\u751f\u7269\u5236\u836f\u516c\u53f8\u4e2d\u8131\u9896\u800c\u51fa\u3002\u5efa\u7acb\u8d77\u4e86\u4e00\u6761\u5305\u62ec32\u4e2a\u65b0\u836f\u54c1\u79cd\u7684\u4ea7\u54c1\u94fe\uff0c\u8986\u76d6\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u591a\u4e2a\u75be\u75c5\u9886\u57df\uff0c\u5176\u4e2d7\u4e2a\u54c1\u79cd\u5165\u9009\u56fd\u5bb6\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u4e13\u9879\u3002\u516c\u53f8\u5df2\u67097\u4e2a\u4ea7\u54c1\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aTYVYT<sup>&reg;<\/sup>\uff1b\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u6538\u540c<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aBYVASDA<sup>&reg;<\/sup>\uff1b\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u82cf\u7acb\u4fe1<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aSULINNO<sup>&reg;<\/sup>\uff1b\u5229\u59a5\u6614\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u534e<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aHALPRYZA<sup>&reg;<\/sup>\uff1b\u57f9\u7c73\u66ff\u5c3c\u7247\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u5766<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aPEMAZYRE<sup>&reg;<\/sup>\uff1b\u5965\u96f7\u5df4\u66ff\u5c3c\u7247\uff0c\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b<sup>&reg;<\/sup>\uff1b\u96f7\u83ab\u897f\u5c24\u5355\u6297\uff0c\u5546\u54c1\u540d\uff1a\u5e0c\u5189\u62e9<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aCYRAMZA<sup>&reg;<\/sup>\uff09\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c1\u4e2a\u54c1\u79cd\u5728NMPA\u5ba1\u8bc4\u4e2d\uff0c5\u4e2a\u54c1\u79cd\u8fdb\u5165III\u671f\u6216\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u8fd8\u670919\u4e2a\u4ea7\u54c1\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u4fe1\u8fbe\u751f\u7269\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u5177\u6709\u56fd\u9645\u5148\u8fdb\u6c34\u5e73\u7684\u9ad8\u7aef\u751f\u7269\u836f\u5f00\u53d1\u3001\u4ea7\u4e1a\u5316\u4eba\u624d\u56e2\u961f\uff0c\u5305\u62ec\u4f17\u591a\u6d77\u5f52\u4e13\u5bb6\uff0c\u5e76\u4e0e\u7f8e\u56fd\u793c\u6765\u5236\u836f\u3001Adimab\u3001Incyte\u3001MD Anderson \u764c\u75c7\u4e2d\u5fc3\u548c\u97e9\u56fdHanmi\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1a<a target=\"_blank\" href=\"http:\/\/www.innoventbio.com\/\" rel=\"nofollow noopener\">www.innoventbio.com<\/a> \u6216\u516c\u53f8\u9886\u82f1\u8d26\u53f7<a target=\"_blank\" href=\"http:\/\/www.linkedin.com\/company\/innovent-biologics\/\" rel=\"nofollow noopener\">www.linkedin.com\/company\/innovent-biologics\/<\/a>\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u201c\u9884\u671f\u201d\u3001\u201c\u76f8\u4fe1\u201d\u3001\u201c\u9884\u6d4b\u201d\u3001\u201c\u671f\u671b\u201d\u3001\u201c\u6253\u7b97\u201d\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u5e76\u65e0\u4e49\u52a1\u4e0d\u65ad\u5730\u66f4\u65b0\u8fd9\u4e9b\u9884\u6d4b\u6027\u9648\u8ff0\u3002<\/p>\n<p>\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n<p>\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u96c7\u5458\u4ee3\u7406\u6982\u4e0d\u627f\u62c5&nbsp;(a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7f51\u7ad9\u6240\u8f7d\u524d\u77bb\u6027\u8868\u8ff0\u4e4b\u4efb\u4f55\u4e49\u52a1\uff1b\u53ca&nbsp;(b) \u5018\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5b9e\u73b0\u6216\u53d8\u6210\u4e0d\u6b63\u786e\u800c\u5f15\u81f4\u4e4b\u4efb\u4f55\u8d23\u4efb\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4ea7\u54c1\u6536\u5165\u783440\u4ebf\uff0c\u8fc8\u5165\u540e\u671f\u7ba1\u7ebf\u6536\u83b7\u671f\uff0c32\u6761\u9ad8\u4ef7\u503c\u4ea7\u54c1\u7ba1\u7ebf\u84c4\u52bf\u5f85\u53d1 \u7f8e\u56fd\u65e7\u91d1\u5c71\u548c\u4e2d\u56fd\u82cf\u5dde2022\u5e743\u670829\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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