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type=\"disc\">\n<li>\u5df4\u897f\u4e09\u9879\u7531\u7814\u7a76\u8005\u53d1\u8d77\u7684\u4e34\u5e8a\u8bd5\u9a8c\u663e\u793a\uff1a\u666e\u514b\u9c81\u80fa\u5bf9\u4e8e\u8f7b\u4e2d\u75c7\u65b0\u51a0\u7537\u3001\u5973\u60a3\u8005\uff08NCT04446429\u548cNCT04853134\uff09\u7684\u6709\u6548\u7387\u5206\u522b\u4e3a92%\u548c\u7ea690%\uff0c\u5bf9\u4e8e\u91cd\u75c7\u65b0\u51a0\u60a3\u8005\uff08NCT04728802\uff09\u7684\u6b7b\u4ea1\u7387\u964d\u4f4e78%\u3002\n<\/li>\n<li>\u6b63\u5728\u79ef\u6781\u63a8\u8fdb\u7531\u516c\u53f8\u4e3b\u5bfc\u7684\u666e\u514b\u9c81\u80fa\u6cbb\u7597\u65b0\u51a0\u7684\u4e09\u4e2a\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5305\u62ec\u5728\u7f8e\u56fd\u7b49\u56fd\u5bb6\u8fdb\u884c\u7684\u6cbb\u7597\u8f7b\u4e2d\u75c7\u65b0\u51a0\u60a3\u8005\u7684\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT04870606\uff09\u548c\u5728\u4e2d\u56fd\u3001\u5df4\u897f\u3001\u83f2\u5f8b\u5bbe\u548c\u9a6c\u6765\u897f\u4e9a\u7b49\u56fd\u5bb6\u5f00\u5c55\u7684\u8f7b\u4e2d\u75c7\u65b0\u51a0\u60a3\u8005\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT04869228\uff09\uff0c\u4ee5\u53ca\u5728\u7f8e\u56fd\u3001\u83f2\u5f8b\u5bbe\u3001\u5357\u975e\u548c\u4e2d\u56fd\u7b49\u56fd\u5bb6\u5f00\u5c55\u7684\u91cd\u75c7\u4f4f\u9662\u65b0\u51a0\u60a3\u8005\u7684\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT05009732\uff09\u3002\n<\/li>\n<li>2021\u5e747\u670813\u65e5\uff0c\u5ba3\u5e03\u666e\u514b\u9c81\u80fa\u83b7\u5df4\u62c9\u572d\u56fd\u5bb6\u516c\u5171\u536b\u751f\u548c\u793e\u4f1a\u798f\u5229\u90e8\uff08MSPBS\uff09\u6388\u4e88\u7d27\u6025\u4f7f\u7528\u6388\u6743\uff08EUA\uff09\uff0c\u7528\u4e8e\u4f4f\u9662\u65b0\u51a0\u60a3\u8005\u7684\u6cbb\u7597\u3002\u53e6\u5916\uff0c\u666e\u514b\u9c81\u80fa\u4e8e2022\u5e741\u6708\u83b7\u6ce2\u65af\u5c3c\u4e9a\u548c\u9ed1\u585e\u54e5\u7ef4\u90a3\uff08\u7b80\u79f0\u201c\u6ce2\u9ed1\u201d\uff09\u8428\u62c9\u70ed\u7a9d\u5dde\u536b\u751f\u90e8\u6388\u4e88EUA\uff0c\u7528\u4e8e\u4f4f\u9662\u65b0\u51a0\u60a3\u8005\u7684\u6cbb\u7597\uff0c\u4ee5\u53ca\u4e8e2022\u5e743\u6708\u83b7\u52a0\u7eb3\u5171\u548c\u56fd\u536b\u751f\u90e8\u6388\u6743\u4f7f\u7528\u3002\n<\/li>\n<li>2021\u5e7412\u670827\u65e5\uff0c\u516c\u5e03\u666e\u514b\u9c81\u80fa\u6cbb\u7597\u8f7b\u4e2d\u75c7\u65b0\u51a0\u60a3\u8005\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT04870606\uff09\u7684\u4e2d\u671f\u5206\u6790\u7ed3\u679c\uff0c\u7531\u4e8e\u4e8b\u4ef6\u6570\u8f83\u5c11\u800c\u672a\u663e\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u57fa\u4e8e\u4e2d\u671f\u5206\u6790\u7ed3\u679c\uff0c\u666e\u514b\u9c81\u80fa\u7684\u5b89\u5168\u6027\u826f\u597d\uff0c\u6ca1\u6709\u62a5\u544a\u4e00\u4f8b\u836f\u7269\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6(SAEs)\u3002\n<\/li>\n<li>2022\u5e742\u670810\u65e5\uff0c\u5728\u4e2d\u56fd\u3001\u5df4\u897f\u3001\u83f2\u5f8b\u5bbe\u548c\u9a6c\u6765\u897f\u4e9a\u7b49\u56fd\u5bb6\u5f00\u5c55\u7684\u666e\u514b\u9c81\u80fa\u6cbb\u7597\u8f7b\u4e2d\u75c7\u65b0\u51a0\u60a3\u8005\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT04869228\uff09\u5728\u6df1\u5733\u5e02\u7b2c\u4e09\u4eba\u6c11\u533b\u9662\u5b8c\u6210\u4e2d\u56fd\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\u7ed9\u836f\u3002<\/li>\n<\/ul>\n<p>\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c<\/p>\n<ul type=\"disc\">\n<li>\u6b63\u5728\u4e2d\u56fd\u5f00\u5c55\u666e\u514b\u9c81\u80fa\u4f5c\u4e3a\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\uff08mCRPC\uff09\u4e8c\u7ebf\u7597\u6cd5\u3001\u666e\u514b\u9c81\u80fa\u548c\u963f\u6bd4\u7279\u9f99\u8054\u7528\u4f5c\u4e3a\u4e00\u7ebf\u7597\u6cd5\u7684\u4e24\u9879III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\n<\/li>\n<li>2021\u5e742\u6708\uff0c\u516c\u53f8\u5728ASCO GU\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86\u666e\u514b\u9c81\u80fa\u5355\u836f\u6cbb\u7597mCRPC\u7684\u4e2d\u56fdII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u548c\u666e\u514b\u9c81\u80fa\u6cbb\u7597mCRPC\u7684\u7f8e\u56fdII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u671f\u6570\u636e\u3002\n<\/li>\n<li>2022\u5e742\u670824\u65e5\uff0c\u666e\u514b\u9c81\u80fa\u548c\u963f\u6bd4\u7279\u9f99\u8054\u7528\u4e00\u7ebf\u6cbb\u7597mCRPC\u7684\u4e2d\u56fdIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u6240\u6709718\u540d\u53d7\u8bd5\u8005\u5165\u7ec4\u3002\n<\/li>\n<li>\u666e\u514b\u9c81\u80fa\u6cbb\u7597mCRPC\u7684\u7f8e\u56fdII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u6570\u636e\u5206\u6790\u3002<\/li>\n<\/ul>\n<p>AR+\u8f6c\u79fb\u6027\u4e73\u817a\u764c<\/p>\n<ul type=\"disc\">\n<li>\u6b63\u5728\u4e2d\u56fd\u5f00\u5c55\u5f00\u653e\u3001\u591a\u4e2d\u5fc3\u7684Ic\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u8bc4\u4f30\u666e\u514b\u9c81\u80fa\u8054\u5408\u4f9d\u897f\u7f8e\u5766\u3001\u6765\u66f2\u5511\u53ca\u6c1f\u7ef4\u53f8\u7fa4\u5bf9AR+\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08mBC\uff09\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u836f\u7269\u52a8\u529b\u5b66\u5206\u6790\u53ca\u521d\u6b65\u7597\u6548\u3002\u8be5Ic\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u4e8e2021\u5e748\u670825\u65e5\u5b8c\u6210\u60a3\u8005\u62db\u52df\u3002<\/li>\n<\/ul>\n<p>\u9884\u671f\u91cc\u7a0b\u7891<\/p>\n<ul type=\"disc\">\n<li>\u5728\u7f8e\u56fd\u7b49\u56fd\u5bb6\u8fdb\u884c\u7684\u666e\u514b\u9c81\u80fa\u6cbb\u7597\u8f7b\u4e2d\u75c7\u65b0\u51a0\u60a3\u8005III\u671f\u4e34\u5e8a\u8bd5\u9a8c(NCT04870606)\u7684\u9876\u7ebf(top-line)\u6570\u636e\u5373\u5c06\u516c\u5e03\u3002\n<\/li>\n<li>2022\u5e74\u4e0b\u534a\u5e74\uff0c\u516c\u5e03\u5728\u4e2d\u56fd\u3001\u5df4\u897f\u3001\u83f2\u5f8b\u5bbe\u548c\u9a6c\u6765\u897f\u4e9a\u7b49\u56fd\u5bb6\u5f00\u5c55\u7684\u8f7b\u4e2d\u75c7\u65b0\u51a0\u60a3\u8005\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8c(NCT04869228)\u4e2d\u671f\u5206\u6790\u6570\u636e\u3002<\/li>\n<\/ul>\n<p>\u798f\u745e\u4ed6\u6069\uff08KX-826\uff09<\/p>\n<p>\u5916\u7528AR\u62ee\u6297\u5242\uff0c\u6b63\u5728\u8fdb\u884c\u7537\u5973\u96c4\u6fc0\u7d20\u6027\u8131\u53d1\uff08AGA\uff09\u3001\u75e4\u75ae\u6cbb\u7597\u7684\u4e34\u5e8a\u5f00\u53d1\u3002\u798f\u745e\u4ed6\u6069\u662f\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u6ce8\u518c\u6027III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7528\u4e8eAGA\u6cbb\u7597\u7684AR\u62ee\u6297\u5242\u3002<\/p>\n<p>\u96c4\u6fc0\u7d20\u6027\u8131\u53d1<\/p>\n<ul type=\"disc\">\n<li>\u9488\u5bf9\u7537\u6027AGA\uff0c\u6b63\u5728\u4e2d\u56fd\u8fdb\u884cIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u548c\u5728\u7f8e\u56fd\u8fdb\u884cII\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u9488\u5bf9\u5973\u6027AGA\uff0c\u6b63\u5728\u4e2d\u56fd\u8fdb\u884cII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\n<\/li>\n<li>2021\u5e749\u67088\u65e5\uff0c\u5ba3\u5e03\u798f\u745e\u4ed6\u6069\u6cbb\u7597\u7537\u6027AGA\u7684\u4e2d\u56fdII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u8fbe\u5230\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\uff0c\u7ed3\u679c\u663e\u793a\u5177\u6709\u826f\u597d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\n<\/li>\n<li>2021\u5e7412\u670831\u65e5\uff0c\u798f\u745e\u4ed6\u6069\u6cbb\u7597\u7537\u6027AGA\u7684\u4e2d\u56fd\u6ce8\u518c\u6027III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\u53ca\u7ed9\u836f\u3002\n<\/li>\n<li>2022\u5e742\u670828\u65e5\uff0c\u798f\u745e\u4ed6\u6069\u6cbb\u7597\u7537\u6027AGA\u7684\u7f8e\u56fdII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\u53ca\u7ed9\u836f\u3002\n<\/li>\n<li>2022\u5e743\u67084\u65e5\uff0c\u798f\u745e\u4ed6\u6069\u6cbb\u7597\u5973\u6027AGA\u7684\u4e2d\u56fdII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u6240\u6709160\u540d\u53d7\u8bd5\u8005\u5165\u7ec4\u3002<\/li>\n<\/ul>\n<p>\u75e4\u75ae<\/p>\n<ul type=\"disc\">\n<li>\u798f\u745e\u4ed6\u6069\u6cbb\u7597\u75e4\u75ae\u7684\u4e2d\u56fdI\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5206\u522b\u4e8e2021\u5e744\u670816\u65e5\u548c2022\u5e741\u670824\u65e5\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\u53ca\u7ed9\u836f\u3002<\/li>\n<\/ul>\n<p>\u9884\u671f\u91cc\u7a0b\u7891<\/p>\n<ul type=\"disc\">\n<li>2022\u5e74\u4e0a\u534a\u5e74\uff0c\u798f\u745e\u4ed6\u6069\u6cbb\u7597\u7537\u6027AGA\u7684\u4e2d\u56fdIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u6240\u6709\u53d7\u8bd5\u8005\u5165\u7ec4\u3002\n<\/li>\n<li>2022\u5e74\u4e0a\u534a\u5e74\uff0c\u798f\u745e\u4ed6\u6069\u6cbb\u7597\u75e4\u75ae\u7684\u4e2d\u56fdII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u6240\u6709\u53d7\u8bd5\u8005\u5165\u7ec4\u3002\n<\/li>\n<li>2022\u5e746\u6708\uff0c\u798f\u745e\u4ed6\u6069\u6cbb\u7597\u7537\u6027AGA\u7684\u4e2d\u56fdII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u5c06\u7531\u4e3b\u8981\u7814\u7a76\u8005\uff08PIs\uff09\u5728\u76f8\u5173\u7814\u8ba8\u4f1a\u4e0a\u5c55\u793a\u3002\n<\/li>\n<li>2022\u5e74\u7b2c\u56db\u5b63\u5ea6\uff0c\u798f\u745e\u4ed6\u6069\u6cbb\u7597\u5973\u6027AGA\u7684\u4e2d\u56fdII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u5f97\u521d\u6b65\u6570\u636e\u3002<\/li>\n<\/ul>\n<p>ALK-1\u5355\u6297\uff08GT90001\uff09<\/p>\n<p>\u65b0\u578b\u6297\u8840\u7ba1\u751f\u6210\u6291\u5236\u5242\uff0c\u6b63\u5728\u8fdb\u884c\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\u548c\u665a\u671f\u6216\u96be\u6cbb\u6027\u5b9e\u4f53\u80bf\u7624\u6cbb\u7597\u7684\u4e34\u5e8a\u5f00\u53d1\u3002\u5f00\u62d3\u836f\u4e1a\u4e8e2018\u5e74\u81ea\u8f89\u745e\u53d6\u5f97ALK-1\u5355\u6297\u5728\u6240\u6709\u7624\u79cd\u9886\u57df\u7684\u72ec\u5bb6\u5168\u7403\u8bb8\u53ef\u3002<\/p>\n<p>\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c<\/p>\n<ul type=\"disc\">\n<li>\u6b63\u5728\u4e2d\u56fd\u53f0\u6e7e\u5f00\u5c55ALK-1\u5355\u6297\u4e0eNivolumab\u8054\u5408\u4e8c\u7ebf\u6cbb\u7597\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u7684Ib\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u30022021\u5e741\u6708\uff0c\u516c\u53f8\u5728ASCO GI\u4e0a\u516c\u5e03\u8be5\u9879\u53f0\u6e7eII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff0c\u7ed3\u679c\u663e\u793a\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a40%\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002\n<\/li>\n<li>2021\u5e742\u670811\u65e5\uff0c\u7f8e\u56fdFDA\u6279\u51c6ALK-1\u5355\u6297\u8054\u5408Nivolumab\u4e8c\u7ebf\u6cbb\u7597HCC\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\n<\/li>\n<li>2021\u5e7410\u67089\u65e5\uff0cALK-1\u5355\u6297(GT90001C)\u8054\u5408Nivolumab\u6cbb\u7597HCC\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(NMPA)\u7684\u6279\u51c6\u3002<\/li>\n<\/ul>\n<p>\u5b9e\u4f53\u80bf\u7624<\/p>\n<ul type=\"disc\">\n<li>2021\u5e7411\u67082\u65e5\uff0cALK-1\u5355\u6297\u8054\u5408\u5eb7\u5b81\u6770\u745e\u751f\u7269\u5236\u836f\u7684\u91cd\u7ec4\u4eba\u6e90\u5316PD-L1\/CTLA-4\u53cc\u7279\u5f02\u6027\u6297\u4f53KN046\u5728\u4e2d\u56fd\u53f0\u6e7e\u8fdb\u884c\u7684\u6cbb\u7597\u665a\u671f\u6216\u96be\u6cbb\u6027\u5b9e\u4f53\u80bf\u7624\u7684Ib\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\u53ca\u7ed9\u836f\u3002<\/li>\n<\/ul>\n<p>\u9884\u671f\u91cc\u7a0b\u7891<\/p>\n<ul type=\"disc\">\n<li>2022\u5e74\u4e0a\u534a\u5e74\uff0cALK-1\u5355\u6297\u8054\u5408Nivolumab\u4e8c\u7ebf\u6cbb\u7597HCC\u7684\u7f8e\u56fdII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\u53ca\u7ed9\u836f\u3002<\/li>\n<\/ul>\n<p>GT20029<\/p>\n<p>\u57fa\u4e8ePROTAC\u6280\u672f\u5f00\u53d1\uff0c\u6b63\u5728\u8fdb\u884cAGA\u548c\u75e4\u75ae\u6cbb\u7597\u7684\u4e34\u5e8a\u5f00\u53d1\u3002GT20029\u662f\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684\u5916\u7528PROTAC\u5316\u5408\u7269\u3002<\/p>\n<p>\u96c4\u6fc0\u7d20\u6027\u8131\u53d1\u548c\u75e4\u75ae<\/p>\n<ul type=\"disc\">\n<li>2021\u5e747\u670828\u65e5\uff0cGT20029\u4e2d\u56fdI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u5b8c\u6210\u9996\u6279\u53d7\u8bd5\u8005\u5165\u7ec4\u53ca\u7ed9\u836f\u3002\n<\/li>\n<li>2022\u5e742\u67083\u65e5\uff0cGT20029\u6cbb\u7597AGA\u548c\u75e4\u75ae\u7684\u7f8e\u56fdI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u4e8e\u5f53\u5730\u65f6\u95f42022\u5e742\u67081\u65e5\u5b8c\u6210\u9996\u4f8b\u53d7\u8bd5\u8005\u5165\u7ec4\u53ca\u7ed9\u836f\u3002<\/li>\n<\/ul>\n<p>\u9884\u671f\u91cc\u7a0b\u7891<\/p>\n<ul type=\"disc\">\n<li>2022\u5e74\u4e0a\u534a\u5e74\uff0cGT20029\u4e2d\u56fdI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u6240\u6709\u53d7\u8bd5\u8005\u5165\u7ec4\u53ca\u7ed9\u836f\u3002\n<\/li>\n<li>2022\u5e74\u4e0b\u534a\u5e74\uff0cGT20029\u7f8e\u56fdI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u6240\u6709\u53d7\u8bd5\u8005\u5165\u7ec4\u53ca\u7ed9\u836f\u3002<\/li>\n<\/ul>\n<p>GT90008<\/p>\n<p>PD-L1\/TGF-\u03b2\u53cc\u9776\u70b9\u6297\u4f53\uff0c\u6b63\u5728\u8fdb\u884c\u665a\u671f\u5b9e\u4f53\u80bf\u7624\u6cbb\u7597\u7684\u4e34\u5e8a\u5f00\u53d1\u3002<\/p>\n<ul type=\"disc\">\n<li>2021\u5e7410\u670821\u65e5\uff0cGT90008\u5df2\u83b7\u5f97\u4e2d\u56fdNMPA\u7684\u6279\u51c6\uff0c\u5f00\u5c55\u665a\u671f\u5b9e\u4f53\u7624\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<\/ul>\n<p>\u9884\u671f\u91cc\u7a0b\u7891<\/p>\n<ul type=\"disc\">\n<li>2022\u5e74\u4e0b\u534a\u5e74\uff0cGT90008\u4e2d\u56fdI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\u53ca\u7ed9\u836f\u3002<\/li>\n<\/ul>\n<p>\u8fea\u62d3\u8d5b\u66ff\uff08GT0486\uff09<\/p>\n<p>PI3K\/mTOR\u4fe1\u53f7\u9014\u5f84\u6291\u5236\u5242\uff0c\u6b63\u5728\u8fdb\u884c\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u6cbb\u7597\u7684\u4e34\u5e8a\u5f00\u53d1\u3002<\/p>\n<ul type=\"disc\">\n<li>\u6b63\u5728\u4e2d\u56fd\u8fdb\u884cI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5242\u91cf\u722c\u5761\u3002<\/li>\n<\/ul>\n<p>GT1708F<\/p>\n<p>hedgehog\u4fe1\u53f7\u8f6c\u5bfc\u9014\u5f84\u6291\u5236\u5242\uff0c\u6b63\u5728\u8fdb\u884c\u8840\u6db2\u80bf\u7624\u548c\u57fa\u5e95\u7ec6\u80de\u764c\u6cbb\u7597\u7684\u4e34\u5e8a\u5f00\u53d1\u3002<\/p>\n<ul type=\"disc\">\n<li>\u6b63\u5728\u4e2d\u56fd\u8fdb\u884c\u6cbb\u7597\u8840\u6db2\u80bf\u7624\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5242\u91cf\u722c\u5761\u3002<\/li>\n<\/ul>\n<p>\u9664\u4e0a\u8ff0\u4e34\u5e8a\u9636\u6bb5\u5728\u7814\u836f\u7269\u4e4b\u5916\uff0c\u516c\u53f8\u6b63\u5728\u5f00\u53d1\u591a\u6b3e\u4e34\u5e8a\u524d\u9636\u6bb5\u836f\u7269\uff0c\u5305\u62ecALK-1\/VEGF\u53cc\u6297\u548cc-Myc\u6291\u5236\u5242\u7b49\u3002<\/p>\n<p><b>\u5546\u4e1a\u5316\u5408\u4f5c<\/b><\/p>\n<p>2021\u5e744\u670812\u65e5\uff0c\u4e0e\u534e\u76ca\u6cf0\u5eb7\u5c31\u6269\u5927\u666e\u514b\u9c81\u80fa\u4ea7\u80fd\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u534f\u8bae\u3002<\/p>\n<p>2021\u5e747\u670815\u65e5\uff0c\u4e0e\u590d\u661f\u533b\u836f\u4ea7\u4e1a\u5c31\u666e\u514b\u9c81\u80fa\u6cbb\u7597\u65b0\u51a0\u5728\u5370\u5ea6\u548c28\u4e2a\u975e\u6d32\u56fd\u5bb6\u7684\u5546\u4e1a\u5316\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u53cc\u65b9\u76f8\u4e92\u5408\u4f5c\u3001\u5171\u540c\u63a8\u8fdb\u666e\u514b\u9c81\u80fa\u65b0\u51a0\u9002\u5e94\u75c7\u7684\u7d27\u6025\u4f7f\u7528\u6388\u6743(EUA)\u7533\u8bf7\u3001\u63a8\u5e7f\u548c\u9500\u552e\u5de5\u4f5c\u3002\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u590d\u661f\u533b\u836f\u4ea7\u4e1a\u5c06\u83b7\u5f97\u666e\u514b\u9c81\u80fa\u5728\u5408\u4f5c\u533a\u57df\u7684\u72ec\u5bb6\u6ce8\u518c\u548c\u5546\u4e1a\u5316\u9500\u552e\u6743\u76ca\uff0c\u5e76\u5c31\u6b64\u652f\u4ed8\u5f00\u62d3\u836f\u4e1a\u4e0d\u8d85\u8fc7\u4eba\u6c11\u5e015.6\u4ebf\u5143\u6b3e\u9879\uff0c\u5305\u542b\u9996\u4ed8\u6b3e\u3001\u5f00\u53d1\u91cc\u7a0b\u7891\u7ea6\u4eba\u6c11\u5e011.1\u4ebf\u5143\u4ee5\u53ca\u5546\u4e1a\u5316\u91cc\u7a0b\u7891\u4e0d\u8d85\u8fc7\u4eba\u6c11\u5e014.5\u4ebf\u5143\u3002\u6b64\u5916\uff0c\u5f00\u62d3\u836f\u4e1a\u5c06\u57fa\u4e8e\u666e\u514b\u9c81\u80fa\u5728\u5408\u4f5c\u533a\u57df\u5185\u7684\u672a\u6765\u51c0\u9500\u552e\u989d\uff0c\u5206\u7ea7\u6536\u53d6\u4e0d\u4f4e\u4e8e\u5229\u6da6\u603b\u989d\u768450%\u4f5c\u4e3a\u9500\u552e\u63d0\u6210\u3002<\/p>\n<p>2021\u5e748\u670825\u65e5\uff0c\u4e0eEtana\u5173\u4e8e\u666e\u514b\u9c81\u80fa\u6cbb\u7597\u65b0\u51a0\u5728\u5370\u5ea6\u5c3c\u897f\u4e9a\u7684\u5546\u4e1a\u5316\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\u3002\u6839\u636e\u534f\u8bae\uff0c\u5f00\u62d3\u836f\u4e1a\u5c06\u83b7\u5f97\u6765\u81eaEtana\u7684\u9996\u4ed8\u6b3e\u4ee5\u53ca\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u6b64\u5916\uff0c\u8fd8\u5c06\u83b7\u5f97\u666e\u514b\u9c81\u80fa\u5728\u5370\u5c3c\u4e0a\u5e02\u9500\u552e\u76f8\u5173\u7684\u7ecf\u6d4e\u5229\u76ca\u3002<\/p>\n<p>2021\u5e749\u67087\u65e5\uff0c\u5ba3\u5e03\u4e0e\u6676\u6cf0\u79d1\u6280\u8fbe\u6210\u5408\u4f5c\uff0c\u65e8\u5728\u901a\u8fc7\u4eba\u5de5\u667a\u80fd\uff08AI\uff09\u4e0e\u8ba1\u7b97\u5316\u5b66\u6280\u672f\u8f85\u52a9\u6297\u80bf\u7624\u5355\u514b\u9686\u6297\u4f53\u836f\u7269\u7814\u53d1\u3002<\/p>\n<p>2021\u5e7412\u670816\u65e5\uff0c\u4e0e\u4e0a\u836f\u63a7\u80a1\u4e3e\u884c\u6218\u7565\u5408\u4f5c\u7b7e\u7ea6\u4eea\u5f0f\u3002<\/p>\n<p><b>\u751f\u4ea7\u8fd0\u8425<\/b><\/p>\n<ul type=\"disc\">\n<li>\u82cf\u5dde\u751f\u4ea7\u57fa\u5730\u901a\u8fc7\u6b27\u76dfQP\u5ba1\u8ba1\u3002\n<\/li>\n<li>\u5efa\u6210\u914a\u5242\u3001\u51dd\u80f6\u5242\u751f\u4ea7\u7ebf\uff0c\u5e76\u83b7\u5f97\u836f\u54c1\u751f\u4ea7\u8bb8\u53ef\u8bc1\u3002\n<\/li>\n<li>\u5546\u4e1a\u5316\u4ea7\u80fd\u50a8\u5907\u8fdb\u4e00\u6b65\u63d0\u5347\uff0c\u76ee\u524d\u5177\u5907\u666e\u514b\u9c81\u80fa100\u4e07\u4eba\u4efd\/\u6708\u4ea7\u80fd\uff0c2022\u5e74\u5e95\u8fbe\u52305000\u4e07\u4eba\u4efd\/\u5e74\u4ea7\u80fd\u3002\n<\/li>\n<li>2021\u5e744\u6708\uff0c\u4f4d\u4e8e\u5e7f\u4e1c\u7701\u73e0\u6d77\u5e02\u91d1\u6e7e\u533a\u7684\u73e0\u6d77\u56fd\u9645\u5065\u5eb7\u6e2f\u7814\u53d1\u57fa\u5730\u542f\u7528\uff0c\u4ee5\u80bf\u7624\u514d\u75ab\u4e3a\u91cd\u70b9\uff0c\u5927\u529b\u63a8\u8fdb\u5f00\u62d3\u751f\u7269\u836f\u7684\u4e34\u5e8a\u7814\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u3002\n<\/li>\n<li>\u4f4d\u4e8e\u6d59\u6c5f\u7701\u5e73\u6e56\u53bf\u7684\u539f\u6599\u836f\u548c\u5236\u5242\u751f\u4ea7\u57fa\u5730\u9879\u76ee\uff0c\u7ea6\u5360\u57304\u4e07\u5e73\u65b9\u7c73\uff0c\u9884\u8ba12022\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u5f00\u5de5\u5efa\u8bbe\u3002<\/li>\n<\/ul>\n<p><b>\u8d44\u672c\u5e02\u573a\u8868\u73b0<\/b><\/p>\n<ul type=\"disc\">\n<li>2021\u5e746\u67082\u65e5\uff0c\u5b8c\u6210\u4e0a\u5e02\u540e\u9996\u6b21\u589e\u53d1\uff0c\u51c0\u52df\u96c6\u8d44\u91d1\u7ea611.6\u4ebf\u6e2f\u5143\uff08\u6298\u54081.5\u4ebf\u7f8e\u5143\uff09\u3002\n<\/li>\n<li>2021\u5e749\u67086\u65e5\uff0c\u6b63\u5f0f\u83b7\u7eb3\u5165\u6052\u751f\u7efc\u5408\u6307\u6570\u548c\u6e2f\u80a1\u901a\uff0c\u8fdb\u4e00\u6b65\u63d0\u5347\u516c\u53f8\u7684\u80a1\u7968\u6d41\u901a\u6027\u3001\u77e5\u540d\u5ea6\u4ee5\u53ca\u6269\u5927\u6295\u8d44\u8005\u57fa\u7840\u3002<\/li>\n<\/ul>\n<p><b>\u5176\u4ed6\u4e1a\u52a1\u4eae\u70b9<\/b><\/p>\n<ul type=\"disc\">\n<li>2021\u5e744\u67089\u65e5\uff0c\u5ba3\u5e03\u57282021\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a(AACR)\u5e74\u4f1a\u4e0a\u901a\u8fc7\u58c1\u62a5(E-Poster)\u7684\u65b9\u5f0f\uff0c\u516c\u5e03\u666e\u514b\u9c81\u80fa\u6cbb\u7597\u65b0\u51a0\u3001c-Myc\u6291\u5236\u5242\u6cbb\u7597\u8840\u764c\u7684\u6700\u65b0\u4e34\u5e8a\u524d\u6570\u636e\u3002\n<\/li>\n<li>2021\u5e745\u670816\u65e5\uff0c\u5ba3\u5e03\u4efb\u547d\u9646\u7fa4\u535a\u58eb\u4e3a\u516c\u53f8\u9996\u5e2d\u6280\u672f\u5b98\uff08CTO\uff09\uff0c\u4e3b\u8981\u8d1f\u8d23\u5316\u5b66\u3001\u751f\u4ea7\u53ca\u63a7\u5236\uff08CMC\uff09\uff0c\u5305\u62ec\u836f\u54c1\u5206\u6790\u3001\u5236\u5242\u7814\u53d1\u53ca\u751f\u4ea7\uff1b\u4efb\u547d\u97e9\u5bb6\u6587\u535a\u58eb\u4e3a\u516c\u53f8\u5546\u52a1\u62d3\u5c55\u526f\u603b\u88c1\uff0c\u4e3b\u8981\u8d1f\u8d23\u5546\u52a1\u62d3\u5c55\u76f8\u5173\u4e1a\u52a1\u548c\u7ba1\u7406\u5de5\u4f5c\u3002\n<\/li>\n<li>2021\u5e7410\u670819\u65e5\uff0c\u4e2d\u5171\u4e2d\u592e\u653f\u6cbb\u5c40\u59d4\u5458\u3001\u56fd\u52a1\u9662\u526f\u603b\u7406\u5b59\u6625\u5170\u5230\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u8c03\u7814\uff0c\u4e86\u89e3\u65b0\u51a0\u75c5\u6bd2\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u3001\u5ba1\u8bc4\u670d\u52a1\u7b49\u60c5\u51b5\uff0c\u5e76\u53ec\u5f00\u76f8\u5173\u4f01\u4e1a\u548c\u4e13\u5bb6\u5ea7\u8c08\u4f1a\uff0c\u542c\u53d6\u836f\u7269\u7814\u53d1\u5de5\u4f5c\u7684\u610f\u89c1\u5efa\u8bae\u3002\u671f\u95f4\uff0c\u7ae5\u535a\u58eb\u4f5c\u4e3a\u4f01\u4e1a\u5bb6\u4ee3\u8868\u53c2\u52a0\u4e86\u5ea7\u8c08\uff0c\u5e76\u4ecb\u7ecd\u4e86\u666e\u514b\u9c81\u80fa\u6cbb\u7597\u65b0\u51a0III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u5c55\u3002\n<\/li>\n<li>2021\u5e7411\u67088\u65e5\uff0c\u5370\u5ea6\u5c3c\u897f\u4e9a\u9a7b\u534e\u5927\u4f7f\u5468\u6d69\u9ece\uff08H.E. 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2022\u5e74\u4e0b\u534a\u5e74\uff0c\u516c\u5e03\u5728\u4e2d\u56fd\u3001\u5df4\u897f\u3001\u83f2\u5f8b\u5bbe\u548c\u9a6c\u6765\u897f\u4e9a\u7b49\u56fd\u5bb6\u5f00\u5c55\u7684\u8f7b\u4e2d\u75c7\u65b0\u51a0\u60a3\u8005\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8c(NCT04869228)\u4e2d\u671f\u5206\u6790\u6570\u636e\u3002 \u798f\u745e\u4ed6\u6069\uff08KX-826\uff09 \u5916\u7528AR\u62ee\u6297\u5242\uff0c\u6b63\u5728\u8fdb\u884c\u7537\u5973\u96c4\u6fc0\u7d20\u6027\u8131\u53d1\uff08AGA\uff09\u3001\u75e4\u75ae\u6cbb\u7597\u7684\u4e34\u5e8a\u5f00\u53d1\u3002\u798f\u745e\u4ed6\u6069\u662f\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u6ce8\u518c\u6027III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7528\u4e8eAGA\u6cbb\u7597\u7684AR\u62ee\u6297\u5242\u3002 \u96c4\u6fc0\u7d20\u6027\u8131\u53d1 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2022\u5e742\u670828\u65e5\uff0c\u798f\u745e\u4ed6\u6069\u6cbb\u7597\u7537\u6027AGA\u7684\u7f8e\u56fdII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\u53ca\u7ed9\u836f\u3002 2022\u5e743\u67084\u65e5\uff0c\u798f\u745e\u4ed6\u6069\u6cbb\u7597\u5973\u6027AGA\u7684\u4e2d\u56fdII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u6240\u6709160\u540d\u53d7\u8bd5\u8005\u5165\u7ec4\u3002 \u75e4\u75ae \u798f\u745e\u4ed6\u6069\u6cbb\u7597\u75e4\u75ae\u7684\u4e2d\u56fdI\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5206\u522b\u4e8e2021\u5e744\u670816\u65e5\u548c2022\u5e741\u670824\u65e5\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\u53ca\u7ed9\u836f\u3002 \u9884\u671f\u91cc\u7a0b\u7891 2022\u5e74\u4e0a\u534a\u5e74\uff0c\u798f\u745e\u4ed6\u6069\u6cbb\u7597\u7537\u6027AGA\u7684\u4e2d\u56fdIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u6240\u6709\u53d7\u8bd5\u8005\u5165\u7ec4\u3002 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