{"id":64831,"date":"2022-03-14T07:00:00","date_gmt":"2022-03-14T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022031407000064831"},"modified":"2022-03-14T18:17:06","modified_gmt":"2022-03-14T10:17:06","slug":"%e4%ba%91%e9%a1%b6%e6%96%b0%e8%80%80%e4%b8%8ecalliditas-therapeutics%e5%b0%b1%e6%89%a9%e5%a4%a7%e6%8e%88%e6%9d%83%e8%8c%83%e5%9b%b4%e8%be%be%e6%88%90%e5%8d%8f%e8%ae%ae%e4%bb%a5%e5%9c%a8%e9%9f%a9","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022031407000064831","title":{"rendered":"\u4e91\u9876\u65b0\u8000\u4e0eCalliditas Therapeutics\u5c31\u6269\u5927\u6388\u6743\u8303\u56f4\u8fbe\u6210\u534f\u8bae\u4ee5\u5728\u97e9\u56fd\u5f00\u53d1\u548c\u5546\u4e1a\u5316NEFECON"},"content":{"rendered":"

\u4e0a\u6d772022\u5e743\u670814\u65e5 \/\u7f8e\u901a\u793e\/ — \u4e91\u9876\u65b0\u8000<\/a>\uff08Everest Medicines\uff0cHKEX 1952.HK\uff09\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u521b\u65b0\u836f\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u6ee1\u8db3\u4e9a\u592a\u5e02\u573a\u5c1a\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\uff0c\u4eca\u65e5\u5ba3\u5e03\u5df2\u4e0eCalliditas Therapeutics AB\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aCALT\uff0c\u7eb3\u65af\u8fbe\u514b\u65af\u5fb7\u54e5\u5c14\u6469\u80a1\u7968\u4ee3\u7801\uff1aCALTX\uff09\u7b7e\u8ba2\u6388\u6743\u534f\u8bae\uff0c\u5c06\u5728\u97e9\u56fd\u5f00\u53d1\u548c\u5546\u4e1a\u5316NEFECON\u7528\u4e8e\u6cbb\u7597\u539f\u53d1\u6027IgA\u80be\u75c5\uff08IgAN\uff09\uff0c\u6269\u5927\u4e86\u73b0\u6709\u7684\u5728\u5927\u4e2d\u534e\u533a\u548c\u65b0\u52a0\u5761\u7684\u8bb8\u53ef\u6743\u3002\u8be5\u534f\u8bae\u662f\u516c\u53f8\u8fdb\u4e00\u6b65\u6269\u5927\u5176\u56fd\u9645\u5546\u4e1a\u7248\u56fe\u6240\u505a\u7684\u6700\u65b0\u52aa\u529b\u3002<\/p>\n

\u4e91\u9876\u65b0\u8000\u9996\u5e2d\u6267\u884c\u5b98\u8584\u79d1\u745e\u535a\u58eb\u8868\u793a\uff1a\u201c<\/span>\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u591f\u8fdb\u4e00\u6b65\u52a0\u5f3a\u4e0eCalliditas\u7684\u5408\u4f5c\uff0c\u5c06\u6388\u6743\u8303\u56f4\u6269\u5927\u5230\u97e9\u56fd\uff0c\u8fd9\u79bb\u6211\u4eec\u5b9e\u73b0\u5f00\u53d1\u548c\u5546\u4e1a\u5316NEFECON\u4ee5\u4f7f\u5176\u6210\u4e3a\u5168\u7403IgA\u80be\u75c5\u6cbb\u7597\u6f5c\u5728\u521b\u65b0\u7597\u6cd5\u8fd9\u4e00\u5171\u540c\u613f\u666f\u53c8\u8fd1\u4e86\u4e00\u6b65\u3002\u867d\u7136\u539f\u53d1\u6027IgA\u80be\u75c5\u5728\u4e9a\u6d32\u7684\u53d1\u75c5\u7387\u6bd4\u4e16\u754c\u5176\u4ed6\u5730\u533a\u66f4\u9ad8\uff0c\u4f46\u76ee\u524d\u5c1a\u672a\u9488\u5bf9\u8be5\u6162\u6027\u75c5\u5f00\u53d1\u51fa\u5b8c\u5584\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u8fd9\u51f8\u663e\u4e86\u60a3\u8005\u5bf9\u4e8e\u521b\u65b0\u836f\u7269\u7684\u91cd\u5927\u800c\u7d27\u8feb\u7684\u9700\u6c42\u672a\u5f97\u5230\u6ee1\u8db3\u3002\u201d<\/span><\/p>\n

\u4e91\u9876\u65b0\u8000\u9996\u5e2d\u5546\u52a1\u5b98\u90ed\u6c38\u5f3a\u8c03\uff1a\u201c<\/span>\u97e9\u56fd\u662f\u4e9a\u592a\u5730\u533a\u7b2c\u4e09\u5927\u533b\u836f\u5e02\u573a\uff0c\u4ec5\u6b21\u4e8e\u4e2d\u56fd\u548c\u65e5\u672c\uff0c\u663e\u793a\u7740\u5de8\u5927\u7684\u673a\u9047\u3002\u8be5\u56fd\u7684\u533b\u7597\u6a21\u5f0f\u5df2\u8f83\u4e3a\u6210\u719f\uff0c\u610f\u5473\u7740NEFECON\u7b49\u521b\u65b0\u836f\u7269\u4e00\u65e6\u83b7\u6279\uff0c\u4fbf\u6709\u66f4\u5927\u7684\u53ef\u80fd\u6027\u53ef\u4ee5\u7eb3\u5165\u5065\u5eb7\u4fdd\u9669\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u6240\u6709\u76f8\u5173\u65b9\u5bc6\u5207\u5408\u4f5c\uff0c\u5c3d\u5feb\u5c06NEFECON\u5e26\u7ed9\u97e9\u56fd\u7684IgA\u80be\u75c5\u60a3\u8005\u3002\u201d<\/span><\/p>\n

Calliditas\u7684\u9996\u5e2d\u6267\u884c\u5b98Renée Aguiar-Lucander\u8868\u793a\uff1a\u201c<\/span>\u6211\u4eec\u5c06\u7ee7\u7eed\u4e0e\u4e91\u9876\u65b0\u8000\u5f00\u5c55\u5bcc\u6709\u6210\u6548\u7684\u5408\u4f5c\uff0c\u540c\u65f6\u5f88\u9ad8\u5174\u770b\u5230\u6211\u4eec\u5c31\u5728\u97e9\u56fd\u5f00\u53d1\u548c\u5546\u4e1a\u5316NEFECON\u4e5f\u8fbe\u6210\u4e86\u534f\u8bae\u3002\u201d<\/span><\/p>\n

\u5728\u672a\u6765\u7684\u51e0\u4e2a\u6708\uff0c\u4e91\u9876\u65b0\u8000\u5c06\u4e0e\u97e9\u56fd\u98df\u54c1\u548c\u836f\u54c1\u5b89\u5168\u90e8\u5408\u4f5c\uff0c\u51c6\u5907NEFECON\u7528\u4e8e\u6cbb\u7597\u539f\u53d1\u6027IgA\u80be\u75c5\u7684\u76d1\u7ba1\u6587\u4ef6\u548c\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\u3002<\/p>\n

\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0cCalliditas\u5728\u7b7e\u7f72\u534f\u8bae\u65f6\u6536\u5230300\u4e07\u7f8e\u5143\u7684\u521d\u59cb\u9884\u4ed8\u6b3e\u3002<\/p>\n

\u5173\u4e8e<\/b>NEFECON<\/b><\/p>\n

NEFECON\uff08\u5728\u7f8e\u56fd\u4ee5\u53e6\u4e00\u4e2a\u5546\u54c1\u540d\u83b7\u5f97\u52a0\u901f\u6279\u51c6\uff09\u662f\u53e3\u670d\u9776\u5411\u5e03\u5730\u5948\u5fb7\u8fdf\u91ca\u80f6\u56ca\uff0c\u8be5\u76ae\u8d28\u7c7b\u56fa\u9187\u836f\u7269\u5177\u6709\u5f3a\u5927\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6d3b\u6027\u548c\u5fae\u5f31\u7684\u77ff\u7269\u7c7b\u76ae\u8d28\u6fc0\u7d20\u6d3b\u6027\uff0c\u4f1a\u8fdb\u884c\u5927\u91cf\u7684\u9996\u8fc7\u4ee3\u8c22\u3002\u5b83\u88ab\u8bbe\u8ba1\u4e3a4mg\u7684\u8fdf\u91ca\u80f6\u56ca\uff0c\u5e76\u4ee5\u80a0\u6eb6\u8863\u5305\u8986\uff0c\u4ee5\u4fbf\u5728\u9012\u9001\u81f3\u56de\u80a0\u4e4b\u524d\u4fdd\u6301\u5b8c\u6574\u3002\u6bcf\u7c92\u80f6\u56ca\u5747\u542b\u6709\u5e03\u5730\u5948\u5fb7\u5305\u8863\u5fae\u4e38\uff0c\u9776\u5411\u56de\u80a0\u4e2d\u7684\u7c98\u819cB\u7ec6\u80de\uff0c\u5305\u62ec\u6d3e\u5c14\u96c6\u5408\u6dcb\u5df4\u7ed3\u5904\uff08\u8d1f\u8d23\u4ea7\u751f\u53ef\u5bfc\u81f4IgA\u80be\u75c5\u7684\u534a\u4e73\u7cd6\u7f3a\u9677\u7684IgA1\u6297\u4f53\uff08Gd-Ag1\uff09\uff09\u3002\u76ee\u524d\u5c1a\u4e0d\u660e\u786eNEFECON\u7684\u7597\u6548\u5728\u591a\u5927\u7a0b\u5ea6\u4e0a\u662f\u901a\u8fc7\u56de\u80a0\u5c40\u90e8\u4f5c\u7528\u548c\u5168\u8eab\u4f5c\u7528\u4ecb\u5bfc\u7684\u30022019\u5e746\u6708\uff0c\u4e91\u9876\u65b0\u8000\u4e0eCalliditas\u7b7e\u8ba2\u4e86\u4e00\u4efd\u9644\u5e26\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u7684\u72ec\u5bb6\u8bb8\u53ef\u534f\u8bae\uff0c\u6388\u4e88\u4e91\u9876\u65b0\u8000\u5728\u5927\u4e2d\u534e\u533a\u548c\u65b0\u52a0\u5761\u5f00\u53d1\u548c\u5546\u4e1a\u5316NEFECON\u7684\u72ec\u5bb6\u6743\u5229\u3002\u8be5\u534f\u8bae\u4e8e2022\u5e743\u6708\u8fdb\u4e00\u6b65\u6269\u5c55\uff0c\u5c06\u97e9\u56fd\u7eb3\u5165\u4e91\u9876\u65b0\u8000\u7684\u8bb8\u53ef\u8303\u56f4\u3002<\/p>\n

\u5173\u4e8e\u539f\u53d1\u6027\u514d\u75ab\u7403\u86cb\u767d<\/b>A<\/b>\u80be\u75c5\uff08<\/b>IgA<\/b>\u80be\u75c5\uff09<\/b><\/p>\n

\u539f\u53d1\u6027\u514d\u75ab\u7403\u86cb\u767dA\u80be\u75c5\uff08IgA\u80be\u75c5\uff0cIgAN\u6216\u4f2f\u683c\u6c0f\u75c5\uff09\u662f\u4e00\u79cd\u4fb5\u88ad\u80be\u810f\u7684\u8fdb\u884c\u6027\u6162\u6027\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5f53\u81ea\u8eab\u6297\u4f53\u8bc6\u522b\u51fa\u534a\u4e73\u7cd6\u7f3a\u9677\u7684IgA1\u5206\u5b50\u65f6\u51fa\u73b0\uff0c\u53ef\u4ea7\u751fIgA1\u514d\u75ab\u590d\u5408\u7269\uff0c\u5e76\u6c89\u79ef\u5728\u80be\u5c0f\u7403\u7cfb\u819c\u4e2d[1],[2]<\/sup>\u3002\u8fd9\u79cd\u80be\u810f\u6c89\u79ef\u53ef\u5bfc\u81f4\u8fdb\u884c\u6027\u80be\u810f\u635f\u5bb3\uff0c\u5e76\u53ef\u80fd\u5bfc\u81f4\u7ec8\u672b\u671f\u80be\u810f\u75be\u75c5\u3002IgA\u80be\u75c5\u6700\u5e38\u5728\u9752\u5c11\u5e74\u665a\u671f\u81f3\u8fd140\u5c81\u65f6\u53d1\u75c5[2],[3]<\/sup>\u3002<\/span><\/p>\n

\u5173\u4e8e\u4e91\u9876\u65b0\u8000<\/b><\/p>\n

\u4e91\u9876\u65b0\u8000\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u521b\u65b0\u836f\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u6ee1\u8db3\u4e9a\u6d32\u5e02\u573a\u5c1a\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002\u4e91\u9876\u65b0\u8000\u7684\u7ba1\u7406\u56e2\u961f\u5728\u4e9a\u6d32\u53ca\u5168\u7403\u5236\u836f\u4f01\u4e1a\u4ece\u4e8b\u8fc7\u9ad8\u8d28\u91cf\u4e34\u5e8a\u5f00\u53d1\u3001\u836f\u653f\u4e8b\u52a1\u3001\u5316\u5b66\u5236\u9020\u4e0e\u63a7\u5236\uff08CMC\uff09\u3001\u4e1a\u52a1\u53d1\u5c55\u548c\u8fd0\u8425\uff0c\u62e5\u6709\u6df1\u539a\u7684\u4e13\u957f\u548c\u4e30\u5bcc\u7684\u7ecf\u9a8c\u3002\u4e91\u9876\u65b0\u8000\u5df2\u6253\u902011\u6b3e\u6709\u6f5c\u529b\u6210\u4e3a\u5168\u7403\u540c\u7c7b\u9996\u521b\u6216\u8005\u540c\u7c7b\u6700\u4f73\u7684\u836f\u7269\u7ec4\u5408\uff0c\u5176\u4e2d\u5927\u90e8\u5206\u5df2\u7ecf\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u540e\u671f\u9636\u6bb5\u3002\u516c\u53f8\u7684\u6cbb\u7597\u9886\u57df\u5305\u62ec\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u5fc3\u80be\u75be\u75c5\u3001\u611f\u67d3\u6027\u548c\u4f20\u67d3\u6027\u75be\u75c5\u3002\u6709\u5173\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1awww.everestmedicines.com<\/a>\u3002<\/p>\n

\u5173\u4e8e<\/b>Calliditas<\/b><\/p>\n

Calliditas Therapeutics\u662f\u4e00\u5bb6\u603b\u90e8\u4f4d\u4e8e\u745e\u5178\u65af\u5fb7\u54e5\u5c14\u6469\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u8bc6\u522b\u3001\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u5b64\u513f\u75c5\u9002\u5e94\u75c7\u7684\u521b\u65b0\u7597\u6cd5\uff0c\u6700\u521d\u4e13\u6ce8\u4e8e\u5177\u6709\u91cd\u5927\u672a\u6ee1\u8db3\u533b\u7597\u9700\u6c42\u7684\u80be\u810f\u548c\u809d\u810f\u75be\u75c5\u3002Calliditas\u5df2\u5728\u7eb3\u65af\u8fbe\u514b\u65af\u5fb7\u54e5\u5c14\u6469\uff08\u80a1\u7968\u4ee3\u7801\uff1aCALTX\uff09\u548c\u7eb3\u65af\u8fbe\u514b\u5168\u7403\u7cbe\u9009\u5e02\u573a\uff08\u80a1\u7968\u4ee3\u7801\uff1aCALT\uff09\u4e0a\u5e02\u3002\u8bbf\u95eewww.calliditas.com<\/a> \u4ee5\u83b7\u53d6\u66f4\u591a\u4fe1\u606f\u3002<\/p>\n

\n\n\n\n\n\n
\n

[1] Barratt, J., & Feehally, J. (2005).IgA nephropathy.J Am Soc Nephrol<\/i>.16(7), 2088-2097. https:\/\/doi.org\/10.1681\/ASN.2005020134<\/a> <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[2] Barratt, J., Rovin, B. H., Cattran, D., et al.(2020).Why Target the Gut to Treat IgA Nephropathy? Kidney Int Rep<\/i>.5(10), 1620-1624. https:\/\/doi.org\/10.1016\/j.ekir.2020.08.009<\/a> <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[3] Jarrick, S., Lundberg, S., Welander, A., et al.(2019).Mortality in IgA Nephropathy: A Nationwide Population-Based Cohort Study.J Am Soc Nephrol<\/i>.30(5), 866-876.https:\/\/doi.org\/10.1681\/ASN.2018101017<\/a><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n\n

\u524d\u77bb\u6027\u58f0\u660e\uff1a<\/p>\n

\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\uff0c\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u6216\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u516c\u53f8\u4e1a\u52a1\u8fd0\u8425\u60c5\u51b5\u53ca\u8d22\u52a1\u72b6\u51b5\u7684\u73b0\u6709\u770b\u6cd5\u3001\u76f8\u4fe1\u3001\u548c\u73b0\u6709\u9884\u671f\uff0c\u53ef\u80fd\u4f1a\u4f7f\u7528"\u5c06"\u3001"\u9884\u671f"\u3001"\u9884\u6d4b"\u3001"\u671f\u671b"\u3001"\u6253\u7b97"\u3001"\u8ba1\u5212"\u3001"\u76f8\u4fe1"\u3001"\u9884\u4f30"\u3001"\u786e\u4fe1"\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u3002\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u4e1a\u7ee9\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7b49\u5404\u79cd\u56e0\u7d20\u53ca\u5047\u8bbe\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002\u672c\u516c\u53f8\u53ca\u5404\u9644\u5c5e\u516c\u53f8\u3001\u5404\u4f4d\u8463\u4e8b\u3001\u7ba1\u7406\u4eba\u5458\u3001\u987e\u95ee\u53ca\u4ee3\u7406\u672a\u66fe\u4e14\u6982\u4e0d\u627f\u62c5\u66f4\u65b0\u8be5\u7a3f\u4ef6\u6240\u8f7d\u524d\u77bb\u6027\u8868\u8ff0\u4ee5\u53cd\u6620\u5728\u672c\u65b0\u95fb\u7a3f\u53d1\u5e03\u65e5\u540e\u6700\u65b0\u4fe1\u606f\u3001\u672a\u6765\u9879\u76ee\u6216\u60c5\u5f62\u7684\u4efb\u4f55\u4e49\u52a1\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u6d772022\u5e743\u670814\u65e5 \/\u7f8e\u901a\u793e\/ — \u4e91\u9876\u65b0\u8000\uff08Everest Medicines\uff0cHKEX 1952.HK\uff09\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u521b\u65b0\u836f\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u6ee1\u8db3\u4e9a\u592a\u5e02\u573a\u5c1a\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\uff0c\u4eca\u65e5\u5ba3\u5e03\u5df2\u4e0eCalliditas Therapeutics AB\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aCALT\uff0c\u7eb3\u65af\u8fbe\u514b\u65af\u5fb7\u54e5\u5c14\u6469\u80a1\u7968\u4ee3\u7801\uff1aCALTX\uff09\u7b7e\u8ba2\u6388\u6743\u534f\u8bae\uff0c\u5c06\u5728\u97e9\u56fd\u5f00\u53d1\u548c\u5546\u4e1a\u5316NEFECON\u7528\u4e8e\u6cbb\u7597\u539f\u53d1\u6027IgA\u80be\u75c5\uff08IgAN\uff09\uff0c\u6269\u5927\u4e86\u73b0\u6709\u7684\u5728\u5927\u4e2d\u534e\u533a\u548c\u65b0\u52a0\u5761\u7684\u8bb8\u53ef\u6743\u3002\u8be5\u534f\u8bae\u662f\u516c\u53f8\u8fdb\u4e00\u6b65\u6269\u5927\u5176\u56fd\u9645\u5546\u4e1a\u7248\u56fe\u6240\u505a\u7684\u6700\u65b0\u52aa\u529b\u3002 \u4e91\u9876\u65b0\u8000\u9996\u5e2d\u6267\u884c\u5b98\u8584\u79d1\u745e\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u591f\u8fdb\u4e00\u6b65\u52a0\u5f3a\u4e0eCalliditas\u7684\u5408\u4f5c\uff0c\u5c06\u6388\u6743\u8303\u56f4\u6269\u5927\u5230\u97e9\u56fd\uff0c\u8fd9\u79bb\u6211\u4eec\u5b9e\u73b0\u5f00\u53d1\u548c\u5546\u4e1a\u5316NEFECON\u4ee5\u4f7f\u5176\u6210\u4e3a\u5168\u7403IgA\u80be\u75c5\u6cbb\u7597\u6f5c\u5728\u521b\u65b0\u7597\u6cd5\u8fd9\u4e00\u5171\u540c\u613f\u666f\u53c8\u8fd1\u4e86\u4e00\u6b65\u3002\u867d\u7136\u539f\u53d1\u6027IgA\u80be\u75c5\u5728\u4e9a\u6d32\u7684\u53d1\u75c5\u7387\u6bd4\u4e16\u754c\u5176\u4ed6\u5730\u533a\u66f4\u9ad8\uff0c\u4f46\u76ee\u524d\u5c1a\u672a\u9488\u5bf9\u8be5\u6162\u6027\u75c5\u5f00\u53d1\u51fa\u5b8c\u5584\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u8fd9\u51f8\u663e\u4e86\u60a3\u8005\u5bf9\u4e8e\u521b\u65b0\u836f\u7269\u7684\u91cd\u5927\u800c\u7d27\u8feb\u7684\u9700\u6c42\u672a\u5f97\u5230\u6ee1\u8db3\u3002\u201d \u4e91\u9876\u65b0\u8000\u9996\u5e2d\u5546\u52a1\u5b98\u90ed\u6c38\u5f3a\u8c03\uff1a\u201c\u97e9\u56fd\u662f\u4e9a\u592a\u5730\u533a\u7b2c\u4e09\u5927\u533b\u836f\u5e02\u573a\uff0c\u4ec5\u6b21\u4e8e\u4e2d\u56fd\u548c\u65e5\u672c\uff0c\u663e\u793a\u7740\u5de8\u5927\u7684\u673a\u9047\u3002\u8be5\u56fd\u7684\u533b\u7597\u6a21\u5f0f\u5df2\u8f83\u4e3a\u6210\u719f\uff0c\u610f\u5473\u7740NEFECON\u7b49\u521b\u65b0\u836f\u7269\u4e00\u65e6\u83b7\u6279\uff0c\u4fbf\u6709\u66f4\u5927\u7684\u53ef\u80fd\u6027\u53ef\u4ee5\u7eb3\u5165\u5065\u5eb7\u4fdd\u9669\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u6240\u6709\u76f8\u5173\u65b9\u5bc6\u5207\u5408\u4f5c\uff0c\u5c3d\u5feb\u5c06NEFECON\u5e26\u7ed9\u97e9\u56fd\u7684IgA\u80be\u75c5\u60a3\u8005\u3002\u201d Calliditas\u7684\u9996\u5e2d\u6267\u884c\u5b98Renée Aguiar-Lucander\u8868\u793a\uff1a\u201c\u6211\u4eec\u5c06\u7ee7\u7eed\u4e0e\u4e91\u9876\u65b0\u8000\u5f00\u5c55\u5bcc\u6709\u6210\u6548\u7684\u5408\u4f5c\uff0c\u540c\u65f6\u5f88\u9ad8\u5174\u770b\u5230\u6211\u4eec\u5c31\u5728\u97e9\u56fd\u5f00\u53d1\u548c\u5546\u4e1a\u5316NEFECON\u4e5f\u8fbe\u6210\u4e86\u534f\u8bae\u3002\u201d \u5728\u672a\u6765\u7684\u51e0\u4e2a\u6708\uff0c\u4e91\u9876\u65b0\u8000\u5c06\u4e0e\u97e9\u56fd\u98df\u54c1\u548c\u836f\u54c1\u5b89\u5168\u90e8\u5408\u4f5c\uff0c\u51c6\u5907NEFECON\u7528\u4e8e\u6cbb\u7597\u539f\u53d1\u6027IgA\u80be\u75c5\u7684\u76d1\u7ba1\u6587\u4ef6\u548c\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\u3002 \u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0cCalliditas\u5728\u7b7e\u7f72\u534f\u8bae\u65f6\u6536\u5230300\u4e07\u7f8e\u5143\u7684\u521d\u59cb\u9884\u4ed8\u6b3e\u3002 \u5173\u4e8eNEFECON NEFECON\uff08\u5728\u7f8e\u56fd\u4ee5\u53e6\u4e00\u4e2a\u5546\u54c1\u540d\u83b7\u5f97\u52a0\u901f\u6279\u51c6\uff09\u662f\u53e3\u670d\u9776\u5411\u5e03\u5730\u5948\u5fb7\u8fdf\u91ca\u80f6\u56ca\uff0c\u8be5\u76ae\u8d28\u7c7b\u56fa\u9187\u836f\u7269\u5177\u6709\u5f3a\u5927\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6d3b\u6027\u548c\u5fae\u5f31\u7684\u77ff\u7269\u7c7b\u76ae\u8d28\u6fc0\u7d20\u6d3b\u6027\uff0c\u4f1a\u8fdb\u884c\u5927\u91cf\u7684\u9996\u8fc7\u4ee3\u8c22\u3002\u5b83\u88ab\u8bbe\u8ba1\u4e3a4mg\u7684\u8fdf\u91ca\u80f6\u56ca\uff0c\u5e76\u4ee5\u80a0\u6eb6\u8863\u5305\u8986\uff0c\u4ee5\u4fbf\u5728\u9012\u9001\u81f3\u56de\u80a0\u4e4b\u524d\u4fdd\u6301\u5b8c\u6574\u3002\u6bcf\u7c92\u80f6\u56ca\u5747\u542b\u6709\u5e03\u5730\u5948\u5fb7\u5305\u8863\u5fae\u4e38\uff0c\u9776\u5411\u56de\u80a0\u4e2d\u7684\u7c98\u819cB\u7ec6\u80de\uff0c\u5305\u62ec\u6d3e\u5c14\u96c6\u5408\u6dcb\u5df4\u7ed3\u5904\uff08\u8d1f\u8d23\u4ea7\u751f\u53ef\u5bfc\u81f4IgA\u80be\u75c5\u7684\u534a\u4e73\u7cd6\u7f3a\u9677\u7684IgA1\u6297\u4f53\uff08Gd-Ag1\uff09\uff09\u3002\u76ee\u524d\u5c1a\u4e0d\u660e\u786eNEFECON\u7684\u7597\u6548\u5728\u591a\u5927\u7a0b\u5ea6\u4e0a\u662f\u901a\u8fc7\u56de\u80a0\u5c40\u90e8\u4f5c\u7528\u548c\u5168\u8eab\u4f5c\u7528\u4ecb\u5bfc\u7684\u30022019\u5e746\u6708\uff0c\u4e91\u9876\u65b0\u8000\u4e0eCalliditas\u7b7e\u8ba2\u4e86\u4e00\u4efd\u9644\u5e26\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u7684\u72ec\u5bb6\u8bb8\u53ef\u534f\u8bae\uff0c\u6388\u4e88\u4e91\u9876\u65b0\u8000\u5728\u5927\u4e2d\u534e\u533a\u548c\u65b0\u52a0\u5761\u5f00\u53d1\u548c\u5546\u4e1a\u5316NEFECON\u7684\u72ec\u5bb6\u6743\u5229\u3002\u8be5\u534f\u8bae\u4e8e2022\u5e743\u6708\u8fdb\u4e00\u6b65\u6269\u5c55\uff0c\u5c06\u97e9\u56fd\u7eb3\u5165\u4e91\u9876\u65b0\u8000\u7684\u8bb8\u53ef\u8303\u56f4\u3002 \u5173\u4e8e\u539f\u53d1\u6027\u514d\u75ab\u7403\u86cb\u767dA\u80be\u75c5\uff08IgA\u80be\u75c5\uff09 \u539f\u53d1\u6027\u514d\u75ab\u7403\u86cb\u767dA\u80be\u75c5\uff08IgA\u80be\u75c5\uff0cIgAN\u6216\u4f2f\u683c\u6c0f\u75c5\uff09\u662f\u4e00\u79cd\u4fb5\u88ad\u80be\u810f\u7684\u8fdb\u884c\u6027\u6162\u6027\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5f53\u81ea\u8eab\u6297\u4f53\u8bc6\u522b\u51fa\u534a\u4e73\u7cd6\u7f3a\u9677\u7684IgA1\u5206\u5b50\u65f6\u51fa\u73b0\uff0c\u53ef\u4ea7\u751fIgA1\u514d\u75ab\u590d\u5408\u7269\uff0c\u5e76\u6c89\u79ef\u5728\u80be\u5c0f\u7403\u7cfb\u819c\u4e2d[1],[2]\u3002\u8fd9\u79cd\u80be\u810f\u6c89\u79ef\u53ef\u5bfc\u81f4\u8fdb\u884c\u6027\u80be\u810f\u635f\u5bb3\uff0c\u5e76\u53ef\u80fd\u5bfc\u81f4\u7ec8\u672b\u671f\u80be\u810f\u75be\u75c5\u3002IgA\u80be\u75c5\u6700\u5e38\u5728\u9752\u5c11\u5e74\u665a\u671f\u81f3\u8fd140\u5c81\u65f6\u53d1\u75c5[2],[3]\u3002 \u5173\u4e8e\u4e91\u9876\u65b0\u8000 \u4e91\u9876\u65b0\u8000\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u521b\u65b0\u836f\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u6ee1\u8db3\u4e9a\u6d32\u5e02\u573a\u5c1a\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002\u4e91\u9876\u65b0\u8000\u7684\u7ba1\u7406\u56e2\u961f\u5728\u4e9a\u6d32\u53ca\u5168\u7403\u5236\u836f\u4f01\u4e1a\u4ece\u4e8b\u8fc7\u9ad8\u8d28\u91cf\u4e34\u5e8a\u5f00\u53d1\u3001\u836f\u653f\u4e8b\u52a1\u3001\u5316\u5b66\u5236\u9020\u4e0e\u63a7\u5236\uff08CMC\uff09\u3001\u4e1a\u52a1\u53d1\u5c55\u548c\u8fd0\u8425\uff0c\u62e5\u6709\u6df1\u539a\u7684\u4e13\u957f\u548c\u4e30\u5bcc\u7684\u7ecf\u9a8c\u3002\u4e91\u9876\u65b0\u8000\u5df2\u6253\u902011\u6b3e\u6709\u6f5c\u529b\u6210\u4e3a\u5168\u7403\u540c\u7c7b\u9996\u521b\u6216\u8005\u540c\u7c7b\u6700\u4f73\u7684\u836f\u7269\u7ec4\u5408\uff0c\u5176\u4e2d\u5927\u90e8\u5206\u5df2\u7ecf\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u540e\u671f\u9636\u6bb5\u3002\u516c\u53f8\u7684\u6cbb\u7597\u9886\u57df\u5305\u62ec\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u5fc3\u80be\u75be\u75c5\u3001\u611f\u67d3\u6027\u548c\u4f20\u67d3\u6027\u75be\u75c5\u3002\u6709\u5173\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1awww.everestmedicines.com\u3002 \u5173\u4e8eCalliditas Calliditas Therapeutics\u662f\u4e00\u5bb6\u603b\u90e8\u4f4d\u4e8e\u745e\u5178\u65af\u5fb7\u54e5\u5c14\u6469\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u8bc6\u522b\u3001\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u5b64\u513f\u75c5\u9002\u5e94\u75c7\u7684\u521b\u65b0\u7597\u6cd5\uff0c\u6700\u521d\u4e13\u6ce8\u4e8e\u5177\u6709\u91cd\u5927\u672a\u6ee1\u8db3\u533b\u7597\u9700\u6c42\u7684\u80be\u810f\u548c\u809d\u810f\u75be\u75c5\u3002Calliditas\u5df2\u5728\u7eb3\u65af\u8fbe\u514b\u65af\u5fb7\u54e5\u5c14\u6469\uff08\u80a1\u7968\u4ee3\u7801\uff1aCALTX\uff09\u548c\u7eb3\u65af\u8fbe\u514b\u5168\u7403\u7cbe\u9009\u5e02\u573a\uff08\u80a1\u7968\u4ee3\u7801\uff1aCALT\uff09\u4e0a\u5e02\u3002\u8bbf\u95eewww.calliditas.com \u4ee5\u83b7\u53d6\u66f4\u591a\u4fe1\u606f\u3002 [1] Barratt, J., & Feehally, J. (2005).IgA nephropathy.J Am Soc Nephrol.16(7), 2088-2097. https:\/\/doi.org\/10.1681\/ASN.2005020134 [2] Barratt, J., Rovin, B. H., Cattran, D., et al.(2020).Why Target the Gut to Treat IgA Nephropathy? Kidney Int Rep.5(10), 1620-1624.… Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-64831","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/64831","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=64831"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/64831\/revisions"}],"predecessor-version":[{"id":64832,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/64831\/revisions\/64832"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=64831"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=64831"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=64831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}