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18.2\u7684\u6297\u4f53\u5076\u8054\u836f\u7269ATG-022\u5728\u80c3\u764c\u60a3\u8005\u7684\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\u663e\u793a\u4e86\u4f18\u5f02\u7684\u4f53\u5185\u7597\u6548<br \/><b>\u6458\u8981\u7f16\u53f7\uff1a<\/b>1143<br \/><b>\u5206\u4f1a\u573a\uff1a<\/b>\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u836f\u7269\u5b66<br \/><b>\u65e5\u671f\u548c\u65f6\u95f4\uff1a<\/b>2022\u5e744\u670811\u65e5\u4e0a\u53489:00\u81f3\u4e0b\u534812:30\uff08\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f4\uff09<br \/><b>\u5730\u70b9\uff1a<\/b>\u58c1\u62a5\u5c55\u793a\u533a25<\/p>\n<p><b>\u8be5\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u5728\u591a\u4e2a\u80c3\u764c\u60a3\u8005\u7684\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\u5bf9\u9776\u5411\u4f5c\u7528\u4e8e<\/b><b>Claudin 18.2\uff08CLDN18.2\uff09\u7684\u6297\u4f53\u5076\u8054\u836f\u7269ATG-022\u8fdb\u884c\u4e86\u8bc4\u4f30\uff0c\u4ee5\u5224\u65ad\u5176\u5728\u4e0d\u540cCLDN18.2\u8868\u8fbe\u6c34\u5e73\u4e0b\u7684\u6cbb\u7597\u6f5c\u529b\u3002<\/b>\u6709\u76f8\u5f53\u6570\u91cf\u7684\u80c3\u764c\u548c\u80f0\u817a\u764c\u90fd\u5b58\u5728CLDN18.2\u8fc7\u5ea6\u8868\u8fbe\u3002\u9488\u5bf9CLDN18.2\u7684\u5355\u514b\u9686\u6297\u4f53\u836f\u7269\uff08IMAB362\uff09\u7814\u7a76\u663e\u793a\uff0c\u5c3d\u7ba1\u8be5\u836f\u7269\u8054\u5408\u5316\u7597\u663e\u793a\u4e86\u79ef\u6781\u7684\u4e34\u5e8a\u83b7\u76ca\uff0c\u4f46\u5b83\u5728\u4f4e\u8868\u8fbeCLDN18.2\u7684\u75c5\u4eba\u4e2d\u7597\u6548\u5e76\u4e0d\u7406\u60f3\u3002\u8fd9\u9879\u5c06\u5728AACR\u5927\u4f1a\u4e0a\u53d1\u5e03\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\uff1aATG-022\u4ee5\u6781\u9ad8\u7684\u4eb2\u548c\u529b\uff08\u4f4e\u4e8e\u7eb3\u6469\u5c14\u7ea7\u522b\uff09\u4e0eCLDN18.2\u7ed3\u5408\uff0c\u5e76\u663e\u793a\u4e86\u5f3a\u6548\u7684\u4f53\u5185\u548c\u4f53\u5916\u6297\u80bf\u7624\u6d3b\u6027\u3002\u6b64\u5916\uff0c\u8be5\u7814\u7a76\u8fd8\u5728CLDN18.2\u4f4e\u8868\u8fbe\u7684\u80bf\u7624\u6a21\u578b\u4e2d\u89c2\u5bdf\u5230\u4e86\u663e\u8457\u7684\u4f53\u5185\u7597\u6548\u3002\u6587\u7ae0\u7684\u4f5c\u8005\u5728\u7ed3\u8bba\u4e2d\u6307\u51fa\uff0cATG-022\u663e\u793a\u4e86\u4e3a\u5177\u6709\u4e0d\u540cCLDN18.2\u8868\u8fbe\u6c34\u5e73\u7684\u80c3\u764c\u60a3\u8005\u5e26\u6765\u4e34\u5e8a\u83b7\u76ca\u7684\u6f5c\u529b\u3002<b>\u76ee\u524d\uff0c\u5fb7\u742a\u533b\u836f\u6b63\u5728\u63a8\u8fdb<\/b><b>ATG-022\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u3002<br \/><\/b><\/p>\n<p><b>\u6807\u9898\uff1a<\/b>Kras (G12C)\u6291\u5236\u5242\u8054\u5408SHP2\u3001ERK1\/2\u3001mTORC1\/2\u6216XPO1 \u6291\u5236\u5242\u5728\u643a\u5e26Kras (G12C)\u53d8\u5f02\u7684\u80bf\u7624\u4e2d\u7684\u534f\u540c\u6548\u5e94<br \/><b>\u6458\u8981\u7f16\u53f7\uff1a<\/b>2679<br \/><b>\u5206\u4f1a\u573a\uff1a<\/b>\u4fe1\u53f7\u901a\u8def\u6291\u5236\u5242<br \/><b>\u65e5\u671f\u548c\u65f6\u95f4\uff1a<\/b>2022\u5e744\u670812\u65e5\u4e0a\u53489:00\u81f3\u4e0b\u534812:30\uff08\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f4\uff09<br \/><b>\u5730\u70b9\uff1a<\/b>\u58c1\u62a5\u5c55\u793a\u533a25<\/p>\n<p><b>\u8be5\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u65e8\u5728\u5bfb\u627e\u53ef\u514b\u670d<\/b><b>KRAS G12C\u6291\u5236\u5242\u6cbb\u7597\u4e2d\u5e38\u89c1\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u8f83\u77ed\u8fd9\u4e00\u4e34\u5e8a\u56f0\u5883\u7684\u8054\u5408\u7597\u6cd5\u3002<\/b>\u8be5\u7814\u7a76\u5728\u5b9e\u4f53\u80bf\u7624CDX\u6a21\u578b\u4e2d\u8bc4\u4f30\u4e86KRAS G12C\u6291\u5236\u5242ATG-012\u5206\u522b\u8054\u5408\u4f5c\u7528\u4e8e\u591a\u4e2a\u80bf\u7624\u901a\u8def\u7684\u56db\u6b3e\u836f\u7269\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u8fd9\u4e9b\u836f\u7269\u662f\uff1a1\uff09SHP2\u6291\u5236\u5242\uff0cET0038\uff1b2\uff09ERK 1\/2\u6fc0\u9176\u6291\u5236\u5242\uff0cATG-017\uff1b3\uff09TORC1\/2\u6fc0\u9176\u6291\u5236\u5242\uff0cATG-008\uff1b4\uff09XPO-1\u6291\u5236\u5242\uff0c\u585e\u5229\u5c3c\u7d22\u3002\u4e0d\u4ec5ATG-012\u5355\u836f\u53ef\u4ee5\u4f7f\u80bf\u7624\u751f\u957f\u53d7\u5230\u660e\u663e\u6291\u5236\uff0c\u6587\u7ae0\u4f5c\u8005\u540c\u65f6\u6307\u51fa\u8fd9\u56db\u79cd\u836f\u7269\u4e0eATG-012\u7ec4\u6210\u7684\u53cc\u836f\u7ec4\u5408\u5728\u7814\u7a76\u4e2d\u5168\u7a0b\u6301\u7eed\u663e\u793a\u4e86\u660e\u663e\u7684\u4f53\u5185\u534f\u540c\u4f5c\u7528\u3002<b>\u8fd9\u4e9b\u6570\u636e\u63ed\u793a\u4e86\u591a\u4e2a\u6f5c\u5728\u7684<\/b><b>ATG-012\u8054\u5408\u7597\u6cd5\uff0c\u672a\u6765\u53ef\u5728\u643a\u5e26KRAS 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