{"id":63131,"date":"2022-02-23T16:41:00","date_gmt":"2022-02-23T09:41:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022022316410063131"},"modified":"2022-02-24T17:53:38","modified_gmt":"2022-02-24T09:53:38","slug":"sirnaomics%e5%85%ac%e5%b8%83stp705%e6%b2%bb%e7%96%97%e7%9a%ae%e8%82%a4%e5%9f%ba%e5%ba%95%e7%bb%86%e8%83%9e%e7%99%8c%e4%b8%b4%e5%ba%8aii%e6%9c%9f%e4%b8%ad%e6%9c%9f%e6%95%b0%e6%8d%ae","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022022316410063131","title":{"rendered":"Sirnaomics\u516c\u5e03STP705\u6cbb\u7597\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c\u4e34\u5e8aII\u671f\u4e2d\u671f\u6570\u636e"},"content":{"rendered":"

\u9999\u6e2f2022\u5e742\u670823\u65e5 \/\u7f8e\u901a\u793e\/ — Sirnaomics Ltd.\uff08\u201c\u516c\u53f8<\/b>\u201d\uff0c\u201cSirnaomics<\/b>\u201d\uff0c\u80a1\u4efd\u4ee3\u53f7\uff1a2257.HK\uff09\uff0c\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u63a2\u7d22\u53ca\u5f00\u53d1RNAi\u7597\u6cd5\u884c\u4e1a\u9886\u5148\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002Sirnaomics\u516c\u5e03\u5176siRNA\uff08\u5c0f\u5e72\u6270RNA\uff09\u7597\u6cd5STP705\u6cbb\u7597\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c(BCC)II\u671f\u4e2d\u671f\u4e34\u5e8a\u6570\u636e\u3002\u8be5\u4e2d\u671f\u6570\u636e\u4e3a\u4e09\u7ec4\uff08\u517115\u540d\u53d7\u8bd5\u8005\uff09\uff0c\u8868\u660e\u5176\u8fbe\u81f3\u5b8c\u5168\u6e05\u9664\u7597\u6548\u7684\u540c\u65f6\uff0c\u4e5f\u5177\u6709\u6539\u5584\u6216\u7a33\u5b9a\u7684\u7f8e\u5bb9\u6548\u679c\uff0c\u4e14\u65e0\u660e\u663e\u7684\u76ae\u80a4\u4e0d\u826f\u53cd\u5e94\u3002\u4e2d\u671f\u6570\u636e\u8fd8\u663e\u793a\u65e0\u836f\u7269\u76f8\u5173\u7684\u4e0d\u826f\u4e8b\u4ef6(AEs)\u6216\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6(SAEs)\uff0c\u6545\u6b64STP705\u5177\u6709\u5c40\u90e8\u7528\u836f\u6cbb\u7597\u76ae\u80a4\u764c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002<\/p>\n

\u672c\u9879\u5f00\u653e\u6807\u7b7e\u3001\u5242\u91cf\u722c\u5761\u7684\u4e34\u5e8aII\u671f\u8bd5\u9a8c\u4e3b\u8981\u662f\u8bc4\u4f30\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c(BCC)\u60a3\u8005\u5728\u5c40\u90e8\u6ce8\u5c04\u540e\u4e0d\u540c\u5242\u91cfSTP705\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u53ca\u6709\u6548\u6027\u3002\u4e3b\u8981\u7ec8\u70b9\u4e3a\u786e\u5b9a\u539f\u4f4d\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c\u75c5\u7f69\u5185\u7684\u80bf\u7624\u7ec6\u80de\u7ec4\u7ec7\u5b66\u5b8c\u5168\u6e05\u9664\u7597\u6548\u7684\u60a3\u8005\u6bd4\u4f8b\uff0c\u5373\u5728\u75c5\u7076\u4e2d\u65e0\u53ef\u89c2\u5bdf\u5230\u7684BCC\u80bf\u7624\u7ec6\u80de\u5de2\u4f5c\u4e3a\u4e3b\u8981\u4f9d\u636e\u3002\u6b21\u8981\u7ec8\u70b9\u4e3a\u786e\u5b9a\u6700\u4f73\u5242\u91cf\u4e0bSTP705\u7684\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\uff0c\u5e76\u5206\u6790\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c\u5728\u5f62\u6210\u8fc7\u7a0b\u4e2d\u5e38\u89c1\u7684\u751f\u7269\u6807\u5fd7\u7269\uff08\u5305\u62ecTGF-\u03b21\u548cCOX-2\uff09\u3002<\/p>\n

\u672c\u6b21\u4e2d\u671f\u6570\u636e\u5171\u6709\u4e09\u4e2a\u5242\u91cf\u722c\u5761\u7ec4\uff0c\u5176\u8303\u56f4\u4e3a30\u5fae\u514b\u523090\u5fae\u514b\u3002\u6bcf\u7ec4\u75315\u540d\u53d7\u8bd5\u8005\u7ec4\u6210\uff0c\u76ee\u524d\u670915\u540d\u53d7\u8bd5\u8005\u53c2\u4e0e\u662f\u6b21\u8bd5\u9a8c\u3002\u53d7\u8bd5\u8005\u6bcf\u5468\u63a5\u53d7\u4e00\u6b21STP705\u6ce8\u5c04\uff0c\u5e76\u8fde\u7eed\u91cd\u590d\u7ed9\u836f\u516d\u5468\u3002\u5176\u4e2d\uff0cB\u7ec4\u548cC\u7ec4\u5c06\u5206\u522b\u6ce8\u5c0460\u5fae\u514b\u548c90\u5fae\u514b\u7684STP705\uff0c\u4e94\u540d\u53d7\u8bd5\u8005\u4e2d\u6709\u4e09\u540d\u8fbe\u5230\u4e86\u5b8c\u5168\u6e05\u9664\u7597\u6548\u3002A\u7ec4\u5219\u63a5\u53d730\u5fae\u514b\u7684STP705\uff0c\u4e94\u540d\u53d7\u8bd5\u8005\u4e2d\u6709\u4e00\u540d\u8fbe\u6210\u4e86\u5b8c\u5168\u6e05\u9664\u7597\u6548\u3002<\/p>\n

Sirnaomics\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u4f1a\u4e3b\u5e2d\u3001\u6267\u884c\u8463\u4e8b\u3001\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98\u9646\u9633\u535a\u58eb\u8868\u793a\uff1a\u201c\u672c\u6b21\u4e2d\u671f\u6570\u636e\u8868\u660e\uff0cSTP705\u5728\u5df2\u7ecf\u53d6\u5f97\u6cbb\u7597\u76ae\u80a4\u9cde\u764c(SCC)\u79ef\u6781\u6548\u679c\u7684\u57fa\u7840\u4e0a\uff0c\u53c8\u83b7\u5f97\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c(BCC)\u60a3\u8005\u6cbb\u7597\u7684\u79ef\u6781\u54cd\u5e94\u3002\u8fd9\u5c06\u8fdb\u4e00\u6b65\u8bc1\u660e\u672c\u516c\u53f8\u5728\u5f00\u53d1\u5e94\u7528RNAi\u7597\u6cd5\u6cbb\u7597\u76ae\u80a4\u764c\u65b9\u9762\u4e2d\u7684\u9886\u5148\u5730\u4f4d\u3002\u6211\u4eec\u671f\u5f85\u672c\u9879II\u671f\u8bd5\u9a8c\u4e2d\u4f59\u4e0b\u53d7\u8bd5\u8005\u7ec4\u522b\u7684\u6570\u636e\u8bfb\u51fa\u7ed3\u679c\u3002\u4e8b\u56e0\u6211\u4eec\u6b63\u5728\u63a8\u8fdb\u8be5\u91cd\u8981\u5019\u9009\u7597\u6cd5\uff0c\u8fd9\u5c06\u63d0\u5347\u6211\u4eec\u5bf9STP705\u7597\u6548\u7684\u4e86\u89e3\u7a0b\u5ea6\u3002\u201d<\/p>\n

Sirnaomics\u6267\u884c\u8463\u4e8b\u517c\u9996\u5e2d\u533b\u7597\u5b98Michael Molyneaux\u535a\u58eb\u8865\u5145\u9053\uff1a\u201c\u672c\u6b21STP705 II\u671f\u4e2d\u671f\u4e34\u5e8a\u6570\u636e\u4ee4\u4eba\u632f\u594b\uff0c\u8fd9\u8bc1\u660e\u6211\u4eec\u6b63\u8d70\u5728\u4e3a\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u6cbb\u7597\u65b9\u6cd5\u7684\u9053\u8def\u4e0a\u3002\u8fd9\u5c06\u662f\u5bf9\u8fd9\u4e9b\u75c5\u53d8\u8fdb\u884c\u624b\u672f\u5207\u9664\u7684\u66ff\u4ee3\u65b9\u6848\u3002\u76ee\u524d\u5404\u79cd\u7c7b\u578b\u975e\u9ed1\u8272\u7d20\u7624\u76ae\u80a4\u764c\u7684\u975e\u624b\u672f\u6cbb\u7597\u4ecd\u6709\u5de8\u5927\u7684\u533b\u7597\u9700\u6c42\uff0c\u800c\u6211\u4eec\u5df2\u7ecf\u5728\u662f\u6b21\u7814\u7a76\u4e2d\u53d1\u73b0\u8be5\u975e\u624b\u672f\u6cbb\u7597\u65b9\u6848\u4e5f\u53ef\u4ee5\u5b9e\u73b0\u51cf\u5c11\u75a4\u75d5\u548c\u9ad8\u7ec4\u7ec7\u6e05\u9664\u7387\u3002\u201d<\/p>\n

\u672c\u6b21II\u671f\u8bd5\u9a8c\u4f59\u4e0b\u90e8\u5206\u5305\u62ec\u53e6\u5916\u4e24\u7ec4\uff08\u6bcf\u7ec45\u4f4d\uff09120\u5fae\u514b\u548c180\u5fae\u514b\u8bd5\u9a8c\u7ec4\uff0c\u5171\u670925\u4f4d\u53d7\u8bd5\u8005\u53c2\u4e0e\u6574\u4e2a\u672c\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u3002\u6709\u5173\u672c\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5176\u4ed6\u76f8\u5173\u4fe1\u606f\uff0c\u8bf7\u6d4f\u89c8clinicaltrials.gov<\/a>\uff0c\u6807\u8bc6\u7b26\uff1aNCT04669808<\/p>\n

\u5173\u4e8e\u57fa\u5e95\u7ec6\u80de\u764c<\/b><\/p>\n

\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c(BCC)\u662f\u4e00\u79cd\u975e\u9ed1\u8272\u7d20\u7624\u76ae\u80a4\u764c(NMSC)\uff0c\u5176\u5f62\u6210\u539f\u56e0\u4e0e\u9633\u5149\u7684\u7d2b\u5916\u7ebf\u8f90\u5c04\u6709\u5173\u3002\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c\u901a\u5e38\u4e0d\u4f1a\u6269\u6563\u5230\u8eab\u4f53\u7684\u5176\u4ed6\u90e8\u4f4d\uff0c\u56e0\u6b64\u5927\u90e8\u5206\u75c5\u4f8b\u4e3a\u8f6c\u79fb\u524d\u7684\u3002\u6839\u636eCIC\u62a5\u544a\u6307\u51fa\uff0c\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c\u8f6c\u79fb\u7387\u7ea6\u4e3a0.0029%\u548c0.55%\u4e4b\u95f4\uff0c\u5e38\u89c1\u7684\u8f6c\u79fb\u90e8\u4f4d\u4e3a\u533a\u57df\u6dcb\u5df4\u7ed3\u3001\u80ba\u90e8\u3001\u9aa8\u9abc\u3001\u76ae\u80a4\u4e0e\u809d\u810f\u3002\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c\u5e38\u7528\u7684\u6cbb\u7597\u65b9\u6cd5\u4e3a\u666e\u901a\u5916\u79d1\u624b\u672f\u3001\u83ab\u6c0f\u663e\u5fae\u56fe\u50cf\u624b\u672f\u3001\u8f6f\u818f\u5c40\u90e8\u6cbb\u7597\u3001\u51b7\u7597\u3001\u956d\u5c04\u3001\u7535\u5207\u548c\u653e\u5c04\u6cbb\u7597\u3002\u5404\u79cd\u5f62\u5f0f\u7684\u5916\u79d1\u624b\u672f\u4f1a\u5e26\u6765\u660e\u663e\u7684\u76ae\u80a4\u4e0d\u826f\u4e8b\u4ef6\uff1a\u8bf8\u5982\u75a4\u75d5\u3001\u611f\u67d3\u548c\u51fa\u8840\u7b49\u98ce\u9669\u3002\u76ee\u524d\u53ea\u6709\u4e24\u79cd\u836f\u7269\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(FDA)\u6279\u51c6\u7528\u4e8e\u8f6c\u79fb\u524d\u7684\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c\u60a3\u8005\uff0c\u4f46\u4ecd\u7136\u6709\u53ef\u80fd\u5f15\u8d77\u60a3\u8005\u7684\u76ae\u80a4\u53cd\u5e94\u3002<\/p>\n

\u76ee\u524dSTP705\u5e94\u7528\u4e8e\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c\u7684\u6cbb\u7597\uff0c\u663e\u793a\u51fa\u5bf9\u4e8e\u7f8e\u5bb9\u5916\u89c2\u7684\u4f18\u52bf\uff0c\u5c24\u5176\u6709\u6548\u4e8e\u5728\u5934\u90e8\u3001\u9762\u90e8\u6216\u9888\u90e8\u6709\u75c5\u53d8\u7684\u60a3\u8005\u3002\u4e34\u5e8a\u7ed3\u679c\u8868\u660e\uff0c\u4e8e\u76ee\u524d\u53ef\u7528\u7684\u5c40\u90e8\u7597\u6cd5\u76f8\u6bd4\uff0cSTP705\u80fd\u66f4\u9ad8\u5730\u8fbe\u6210\u5b8c\u5168\u6e05\u9664\u7597\u6548\u3002<\/p>\n

\u5173\u4e8e<\/b>STP705<\/b><\/p>\n

Sirnaomics\u516c\u53f8\u7684\u6838\u5fc3\u5019\u9009\u836f\u7269STP705\u662f\u4e00\u79cd\u57fa\u4e8e\u5c0f\u5e72\u6270\u6838\u9178\u7684TGF-\u03b21\/COX-2\u53cc\u9776\u70b9\u6291\u5236\u5242\u3002TGF-\u03b21\u53caCOX-2\u662f\u7ecf\u8fc7\u5145\u5206\u9a8c\u8bc1\u7684\u80bf\u7624\u5b66\u53ca\u7ea4\u7ef4\u5316\u75be\u75c5\u836f\u7269\u5f00\u53d1\u7684\u5b88\u95e8\u4eba\u9776\u70b9\u3002TGF-\u03b21\u8c03\u8282\u5e7f\u6cdb\u7684\u7ec6\u80de\u8fc7\u7a0b\uff0c\u5305\u62ec\u7ec6\u80de\u589e\u6b96\u3001\u5206\u5316\u3001\u51cb\u4ea1\u3001\u7ec6\u80de\u5916\u57fa\u8d28\u751f\u6210\u3001\u8840\u7ba1\u751f\u6210\u3001\u708e\u75c7\u548c\u514d\u75ab\u53cd\u5e94\uff0c\u800cCOX-2\u662f\u4e00\u79cd\u4fc3\u8fdb\u708e\u75c7\u548c\u589e\u6b96\u7684\u4ecb\u8d28\u3002STP705\u901a\u8fc7\u5229\u7528\u5176\u53cc\u9776\u5411\u6291\u5236\u7279\u6027\u548c\u4f18\u5316\u7684\u591a\u80bd\u7eb3\u7c73\u9897\u7c92(PNP)\u9012\u9001\u7cfb\u7edf\uff0c\u91c7\u7528\u5c40\u90e8\u7ed9\u836f\u7597\u6cd5\uff0c\u76f4\u63a5\u6291\u5236\u80bf\u7624\u75c5\u7076\u4e2dTGF-\u03b21\u548cCOX-2\u57fa\u56e0\u8868\u8fbe\u3002\u8be5\u5019\u9009\u836f\u4ea7\u54c1\u7528\u4e8e\u6cbb\u7597\u975e\u9ed1\u8272\u7d20\u7624\u76ae\u80a4\u764c\uff0c\u5305\u62ec\u539f\u4f4d\u9cde\u72b6\u7ec6\u80de\u76ae\u80a4\u764c(isSCC)\u3001\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c(BCC)\u3001\u76ae\u80a4\u7ea4\u7ef4\u5316\u548c\u5b9e\u4f53\u809d\u80bf\u7624\u3002<\/p>\n

\u5173\u4e8e<\/b>Sirnaomics<\/b><\/p>\n

Sirnaomics\u662f\u4e00\u5bb6RNA\u7597\u6cd5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u516c\u53f8\u5019\u9009\u4ea7\u54c1\u5904\u4e8e\u4e34\u5e8a\u524d\u53ca\u4e34\u5e8a\u9636\u6bb5\uff0c\u4e13\u6ce8\u4e8e\u63a2\u7d22\u53ca\u5f00\u53d1\u521b\u65b0\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597\u5b58\u5728\u533b\u7597\u9700\u6c42\u53ca\u5e9e\u5927\u5e02\u573a\u673a\u4f1a\u7684\u9002\u5e94\u75c7\u3002Sirnaomics\u662f\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u5747\u62e5\u6709\u91cd\u8981\u5e02\u573a\u5730\u4f4d\u7684\u9996\u5bb6\u4e34\u5e8a\u9636\u6bb5RNA\u7597\u6cd5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e14\u662f\u9996\u5bb6\u4e3a\u6838\u5fc3\u4ea7\u54c1STP705\u7684RNAi\u7597\u6cd5\u5728\u80bf\u7624\u5b66\u9886\u57df\u53d6\u5f97\u79ef\u6781IIa\u671f\u4e34\u5e8a\u7ed3\u679c\u7684\u516c\u53f8\u3002\u5982\u6b32\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u516c\u53f8\u4fe1\u606f\uff0c\u53ef\u6d4f\u89c8\uff1awww.sirnaomics.com<\/a>\u3002<\/p>\n

\u8054\u7cfb\u65b9\u5f0f\uff1a
<\/b>Michael Molyneaux<\/span>, MD, MBA 
Sirnaomics\u6267\u884c\u8463\u4e8b\u517c\u9996\u5e2d\u533b\u7597\u5b98 
\u7535\u90ae\uff1aMichaelMolyneaux@sirnaomics.com<\/a><\/p>\n

\u6295\u8d44\u8005\u67e5\u8be2\uff1a
<\/b>\u53f6\u6c38\u57fa
Sirnaomics\u4e2d\u56fd\u9996\u5e2d\u8d22\u52a1\u5b98 
\u7535\u90ae\uff1aNigelYip@sirnaomics.com<\/a><\/p>\n

\u7f8e\u56fd\u4f20\u5a92\u67e5\u8be2\uff1a
<\/b>Mark Corbae<\/span>
\u7535\u8bdd\uff1a+1 203 682 8288 
\u7535\u90ae\uff1aMark.Corbae@westwicke.com<\/a> <\/p>\n

\u4e9a\u6d32\u4f20\u5a92\u67e5\u8be2\uff1a
<\/b>\u674e\u8000\u8363
\u7535\u8bdd\uff1a+852 3150 6707 
\u7535\u90ae\uff1asirnaomics.hk@pordahavas.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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\u5173\u4e8eSirnaomics Sirnaomics\u662f\u4e00\u5bb6RNA\u7597\u6cd5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u516c\u53f8\u5019\u9009\u4ea7\u54c1\u5904\u4e8e\u4e34\u5e8a\u524d\u53ca\u4e34\u5e8a\u9636\u6bb5\uff0c\u4e13\u6ce8\u4e8e\u63a2\u7d22\u53ca\u5f00\u53d1\u521b\u65b0\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597\u5b58\u5728\u533b\u7597\u9700\u6c42\u53ca\u5e9e\u5927\u5e02\u573a\u673a\u4f1a\u7684\u9002\u5e94\u75c7\u3002Sirnaomics\u662f\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u5747\u62e5\u6709\u91cd\u8981\u5e02\u573a\u5730\u4f4d\u7684\u9996\u5bb6\u4e34\u5e8a\u9636\u6bb5RNA\u7597\u6cd5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e14\u662f\u9996\u5bb6\u4e3a\u6838\u5fc3\u4ea7\u54c1STP705\u7684RNAi\u7597\u6cd5\u5728\u80bf\u7624\u5b66\u9886\u57df\u53d6\u5f97\u79ef\u6781IIa\u671f\u4e34\u5e8a\u7ed3\u679c\u7684\u516c\u53f8\u3002\u5982\u6b32\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u516c\u53f8\u4fe1\u606f\uff0c\u53ef\u6d4f\u89c8\uff1awww.sirnaomics.com\u3002 \u8054\u7cfb\u65b9\u5f0f\uff1aMichael Molyneaux, MD, MBA Sirnaomics\u6267\u884c\u8463\u4e8b\u517c\u9996\u5e2d\u533b\u7597\u5b98 \u7535\u90ae\uff1aMichaelMolyneaux@sirnaomics.com \u6295\u8d44\u8005\u67e5\u8be2\uff1a\u53f6\u6c38\u57faSirnaomics\u4e2d\u56fd\u9996\u5e2d\u8d22\u52a1\u5b98 \u7535\u90ae\uff1aNigelYip@sirnaomics.com \u7f8e\u56fd\u4f20\u5a92\u67e5\u8be2\uff1aMark Corbae\u7535\u8bdd\uff1a+1 203 682 8288 \u7535\u90ae\uff1aMark.Corbae@westwicke.com  \u4e9a\u6d32\u4f20\u5a92\u67e5\u8be2\uff1a\u674e\u8000\u8363\u7535\u8bdd\uff1a+852 3150 6707 \u7535\u90ae\uff1asirnaomics.hk@pordahavas.com… Read 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