{"id":62553,"date":"2022-02-17T12:56:00","date_gmt":"2022-02-17T05:56:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022021712560062553"},"modified":"2022-02-17T17:58:38","modified_gmt":"2022-02-17T09:58:38","slug":"%e8%bd%ac%e7%a7%bb%e6%80%a7%e5%8e%bb%e5%8a%bf%e6%8a%b5%e6%8a%97%e6%80%a7%e5%89%8d%e5%88%97%e8%85%ba%e7%99%8c%e4%b8%80%e7%ba%bf%e6%b2%bb%e7%96%97%e4%b8%ad%ef%bc%8c%e5%88%a9%e6%99%ae%e5%8d%93%e5%92%8c","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022021712560062553","title":{"rendered":"\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u4e00\u7ebf\u6cbb\u7597\u4e2d\uff0c\u5229\u666e\u5353\u548c\u963f\u6bd4\u7279\u9f99\u8054\u5408\u7597\u6cd5\u6bd4\u6807\u51c6\u7597\u6cd5\u964d\u4f4e\u75be\u75c5\u8fdb\u5c55\u98ce\u9669\u8fbe34%"},"content":{"rendered":"<ul type=\"disc\">\n<li><b>\u4e0e\u5355\u7528\u963f\u6bd4\u7279\u9f99\u6cbb\u7597\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u8054\u5408\u7597\u6cd5\u8010\u53d7\u6027\u826f\u597d\uff0c\u60a3\u8005\u80fd\u591f\u4fdd\u6301\u751f\u6d3b\u8d28\u91cf\u3002<\/b> <\/li>\n<li><b>PROpel<\/b> <b>III \u671f\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u65e0\u8bba\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\u57fa\u56e0\u7a81\u53d8\uff0c\u60a3\u8005\u5747\u53ef\u4ece\u8054\u5408\u7597\u6cd5\u4e2d\u83b7\u76ca\u3002<\/b><\/li>\n<\/ul>\n<p><p>\u4e0a\u6d772022\u5e742\u670817\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; PROpel III \u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u9633\u6027\u7ed3\u679c\u8868\u660e\uff0c\u963f\u65af\u5229\u5eb7\uff08AstraZeneca\uff09\u548c\u9ed8\u6c99\u4e1c\uff08MSD\uff09\u5408\u4f5c\u5f00\u53d1\u7684\u5965\u62c9\u5e15\u5229\uff08\u5546\u54c1\u540d\u5229\u666e\u5353\uff09\u4e0e\u963f\u6bd4\u7279\u9f99\u8054\u5408\u7528\u836f\uff0c\u4e00\u7ebf\u6cbb\u7597\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\uff08mCRPC\uff09\u60a3\u8005\uff0c\u4e0e\u76ee\u524d\u7684\u6807\u51c6\u6cbb\u7597\u963f\u6bd4\u7279\u9f99\u76f8\u6bd4\uff0c\u65e0\u8bba\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\uff08HRR\uff09\u57fa\u56e0\u7a81\u53d8\u72b6\u6001\uff0c\u5f71\u50cf\u5b66\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08rPFS\uff09\u8fbe\u5230\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u6539\u5584\u3002&nbsp;&nbsp;<\/p>\n<p>\u8bd5\u9a8c\u7ed3\u679c\u5c06\u4e8e2\u670817\u65e5\u57282022\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7edf\u764c\u75c7\u7814\u8ba8\u4f1a\u4e0a\u516c\u5e03\u3002<\/p>\n<p>\u524d\u5217\u817a\u764c\u662f\u7537\u6027\u7b2c\u4e8c\u5927\u5e38\u89c1\u764c\u75c7\uff0c\u57282020\u5e74\u5bfc\u81f4\u7ea6375,000\u4eba\u6b7b\u4ea1<sup>[1]<\/sup>\u3002\u665a\u671f\u524d\u5217\u817a\u764c\u60a3\u8005\u9884\u540e\u5f88\u5dee\uff0c\u4e94\u5e74\u751f\u5b58\u7387\u4e00\u76f4\u8f83\u4f4e<sup>[1],[2],[3]<\/sup>\u3002\u5927\u7ea6\u4e00\u534a\u7684mCRPC\u60a3\u8005\u53ea\u63a5\u53d7\u8fc7\u4e00\u7ebf\u6709\u6548\u6cbb\u7597\uff0c\u540e\u7eed\u6cbb\u7597\u7684\u83b7\u76ca\u6709\u9650<sup>[4],[5],[6],[7]<\/sup>\u3002\u5927\u7ea620-30%\u7684mCRPC\u60a3\u8005\u643a\u5e26HRR\u57fa\u56e0\u7a81\u53d8<sup>[8]<\/sup>\u3002<\/p>\n<p>PROpel\u8bd5\u9a8c\u7684\u9996\u5e2d\u7814\u7a76\u5458\uff0c\u8499\u7279\u5229\u5c14\u5927\u5b66\u533b\u7597\u4e2d\u5fc3\u6ccc\u5c3f\u5916\u79d1\u4e3b\u4efb\uff0c\u6ccc\u5c3f\u751f\u6b96\u80bf\u7624\u79d1\u4e3b\u7ba1Fred Saad\u6559\u6388\u8bf4\uff1a\u201c\u6211\u5f88\u6e05\u695a\uff0cmCRPC\u60a3\u8005\u7684\u9884\u540e\u6781\u5dee\uff0c\u800c\u8bb8\u591a\u60a3\u8005\u53ea\u63a5\u53d7\u4e00\u79cd\u6709\u6548\u6cbb\u7597\u3002PROpel\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u4e0e\u963f\u6bd4\u7279\u9f99\u76f8\u6bd4\uff0c\u5965\u62c9\u5e15\u5229\u8054\u5408\u963f\u6bd4\u7279\u9f99\u663e\u8457\u5ef6\u8fdf\u75be\u75c5\u8fdb\u5c55\u8d85\u8fc78\u4e2a\u6708\uff0c\u8fd9\u8868\u660e\u5982\u679c\u83b7\u5f97\u6279\u51c6\uff0c\u8be5\u8054\u5408\u7597\u6cd5\u6709\u53ef\u80fd\u6210\u4e3a\u4e00\u79cd\u65b0\u7684mCRPC\u6807\u51c6\u7597\u6cd5\u3002\u201d <\/p>\n<p>\u963f\u65af\u5229\u5eb7\u80bf\u7624\u7814\u53d1\u6267\u884c\u526f\u603b\u88c1Susan Galbraith\u8bf4\uff1a\u201c\u8fd9\u79cd\u5965\u62c9\u5e15\u5229\u8054\u5408\u7597\u6cd5\u6709\u53ef\u80fd\u8ba9\u4e00\u7ebf\u60a3\u8005\u66f4\u957f\u65f6\u95f4\u5904\u4e8e\u75be\u75c5\u4e0d\u53d1\u751f\u8fdb\u5c55\u7684\u72b6\u6001\uff0c\u540c\u65f6\u8fd8\u4fdd\u6301\u751f\u6d3b\u8d28\u91cf\u3002\u7531\u4e8e\u8bd5\u9a8c\u8bbe\u5b9a\u4e86\u6807\u51c6\u6cbb\u7597\u4f5c\u4e3a\u5bf9\u7167\u8fd9\u6837\u4e00\u4e2a\u9ad8\u6807\u51c6\uff0c\u56e0\u6b64PROpel\u8bd5\u9a8c\u7ed3\u679c\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\uff1a\u4e0e\u6709\u6548\u7684\u6807\u51c6\u6cbb\u7597\u76f8\u6bd4\uff0c\u65e0\u8bbamCRPC\u60a3\u8005\u662f\u5426\u643a\u5e26HRR\u57fa\u56e0\u7a81\u53d8\uff0c\u5965\u62c9\u5e15\u5229\u548c\u963f\u6bd4\u7279\u9f99\u8054\u5408\u7597\u6cd5\u90fd\u663e\u793a\u51fa\u663e\u8457\u7684\u4e34\u5e8a\u6539\u5584\u3002\u201d<\/p>\n<p>\u9ed8\u6c99\u4e1c\u5b9e\u9a8c\u5ba4\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u9ad8\u7ea7\u526f\u603b\u88c1\u3001\u9996\u5e2d\u533b\u5b66\u5b98\u8d1d\u7f57\u6bc5\u535a\u58eb\uff08Roy Baynes\uff09\u8868\u793a\uff1a\u201cPROpel\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u5bf9\u4e8e\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u60a3\u8005\uff0c\u65e0\u8bba\u5176\u751f\u7269\u6807\u5fd7\u7269\u72b6\u6001\u5982\u4f55\uff0c\u4e0e\u963f\u6bd4\u7279\u9f99\u52a0\u6cfc\u5c3c\u677e\u76f8\u6bd4\uff0c\u5965\u62c9\u5e15\u5229\u8054\u5408\u963f\u6bd4\u7279\u9f99\u52a0\u6cfc\u5c3c\u677e\u53ef\u5c06\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e1\/3\u3002\u6211\u4eec\u671f\u5f85\u5c3d\u5feb\u4e0e\u5168\u7403\u533b\u836f\u76d1\u7ba1\u90e8\u95e8\u8ba8\u8bba\u8fd9\u4e9b\u91cd\u8981\u7ed3\u679c\uff0c\u8877\u5fc3\u611f\u8c22\u53c2\u4e0e\u8fd9\u9879\u7814\u7a76\u7684\u60a3\u8005\u3001\u5bb6\u5c5e\u548c\u533b\u62a4\u4eba\u5458\u4eec\u3002\u201d<\/p>\n<p>\u5728\u4e00\u9879\u9884\u5148\u8bbe\u5b9a\u7684\u4e2d\u671f\u5206\u6790\u4e2d\uff0c\u4e0e\u5355\u72ec\u4f7f\u7528\u963f\u6bd4\u7279\u9f99\u76f8\u6bd4\uff0c\u5965\u62c9\u5e15\u5229\u8054\u5408\u963f\u6bd4\u7279\u9f99\u5c06\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8634%\uff08\u98ce\u9669\u6bd4 [HR] 0.66\uff1b95% \u7f6e\u4fe1\u533a\u95f4 [CI] 0.54-0.81\uff1bp&lt; 0.0001\uff09\u3002\u5965\u62c9\u5e15\u5229\u8054\u5408\u963f\u6bd4\u7279\u9f99\u7ec4\u7684\u4e2d\u4f4drPFS\u4e3a24.8\u4e2a\u6708\uff0c\u800c\u963f\u6bd4\u7279\u9f99\u5355\u836f\u7ec4rPFS\u4e3a16.6\u4e2a\u6708\u3002<\/p>\n<p>\u7ed3\u679c\u8fd8\u663e\u793a\uff0c\u4e0e\u5355\u72ec\u4f7f\u7528\u963f\u6bd4\u7279\u9f99\u76f8\u6bd4\uff0c\u5965\u62c9\u5e15\u5229\u8054\u5408\u963f\u6bd4\u7279\u9f99\u6709\u6539\u5584\u603b\u751f\u5b58\uff08OS\uff09\u7684\u6709\u5229\u8d8b\u52bf\uff0c\u4f46\u5728\u6570\u636e\u622a\u6b62\u65f6\u8be5\u8d8b\u52bf\u672a\u8fbe\u5230\u7edf\u8ba1\u5b66\u610f\u4e49\u4e0a\u7684\u5dee\u5f02\uff08\u6570\u636e\u6210\u719f\u5ea6\u4e3a29%\uff09\u3002\u8be5\u8bd5\u9a8c\u5c06\u628aOS\u4f5c\u4e3a\u5173\u952e\u7684\u6b21\u8981\u7ec8\u70b9\u7ee7\u7eed\u8fdb\u884c\u8bc4\u4f30\u3002<\/p>\n<p>\u6765\u81ea\u5176\u4ed6\u4e34\u5e8a\u6709\u6548\u6027\u7ec8\u70b9\u7684\u6570\u636e\uff0c\u5982\u81f3\u9996\u6b21\u540e\u7eed\u6cbb\u7597\u65f6\u95f4\uff08TFST\uff09\u3001\u81f3\u4e8c\u6b21\u8fdb\u5c55\u65f6\u95f4\uff08PFS2\uff09\u3001\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff0c\u4ee5\u53ca\u524d\u5217\u817a\u7279\u5f02\u6027\u6297\u539f\u6c34\u5e73\u548c\u5faa\u73af\u7cfb\u7edf\u80bf\u7624\u7ec6\u80de\u8ba1\u6570\uff0c\u90fd\u8fdb\u4e00\u6b65\u652f\u6301\u5728\u6574\u4e2a\u8bd5\u9a8c\u4eba\u7fa4\u4e2d\uff0c\u4e0e\u5355\u72ec\u4f7f\u7528\u963f\u6bd4\u7279\u9f99\u76f8\u6bd4\uff0c\u5965\u62c9\u5e15\u5229\u548c\u963f\u6bd4\u7279\u9f99\u8054\u5408\u7597\u6cd5\u7684\u6cbb\u7597\u83b7\u76ca\u3002<\/p>\n<p>\u5965\u62c9\u5e15\u5229\u548c\u963f\u6bd4\u7279\u9f99\u8054\u5408\u7597\u6cd5\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u4e0e\u5148\u524d\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u7684\u7ed3\u679c\uff0c\u4ee5\u53ca\u5355\u836f\u6cbb\u7597\u7684\u5df2\u77e5\u7279\u5f81\u4e00\u81f4\u3002\u4e0e\u5355\u72ec\u63a5\u53d7\u963f\u6bd4\u7279\u9f99\u6cbb\u7597\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u5965\u62c9\u5e15\u5229\u8054\u5408\u963f\u6bd4\u7279\u9f99\u6cbb\u7597\u7684\u60a3\u8005\u963f\u6bd4\u7279\u9f99\u7684\u505c\u836f\u7387\u6ca1\u6709\u589e\u52a0\uff0c\u5e76\u4e14\u5bf9\u5065\u5eb7\u76f8\u5173\u7684\u751f\u6d3b\u8d28\u91cf\u6ca1\u6709\u4e0d\u5229\u5f71\u54cd\uff08FACT-P\uff1a\u524d\u5217\u817a\u764c\u6cbb\u7597\u529f\u80fd\u8bc4\u4f30\u95ee\u5377\uff09\u3002<\/p>\n<p><b>PROpel\u8bd5\u9a8c\u7ed3\u679c\u6982\u8981<\/b><\/p>\n<div>\n<table cellspacing=\"0\" cellpadding=\"0\" border=\"0\" class=\"prntblns\">\n<tbody>\n<tr>\n<td class=\"prngen3\"><\/td>\n<td class=\"prngen4\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u5965\u62c9\u5e15\u5229+\u963f\u6bd4\u7279\u9f99 <br \/>(n=399)<\/span><\/p>\n<\/td>\n<td class=\"prngen4\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u5b89\u6170\u5242+\u963f\u6bd4\u7279\u9f99 <br \/>(n=397)<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u7814\u7a76\u8005\u8bc4\u4f30\u7684<\/b><b>rPFS<\/b><sup>[1]<\/sup><\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u53d1\u751f\u4e8b\u4ef6\u7684\u60a3\u8005\u6570\uff08%\uff09<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">168 (42)<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">226 (57)<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">PFS\u4e2d\u4f4d\u503c\uff08\u6708\uff09<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">24.8<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">16.6<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u98ce\u9669\u6bd4\uff0895% \u7f6e\u4fe1\u533a\u95f4\uff09<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\">p\u503c<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">0.66 (0.54, 0.81)<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\">&lt;0.0001<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u7531\u76f2\u6001\u72ec\u7acb\u4e2d\u592e\u5ba1\u67e5\u7ec4<\/b><b>&nbsp;(BICR) \u8bc4\u4f30\u7684rPFS<\/b><sup>[2]<\/sup><\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u53d1\u751f\u4e8b\u4ef6\u7684\u60a3\u8005\u6570\uff08%\uff09<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">157 (39)<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">218 (55)<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">PFS\u4e2d\u4f4d\u503c\uff08\u6708\uff09<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">27.6<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">16.4<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u98ce\u9669\u6bd4\uff0895% \u7f6e\u4fe1\u533a\u95f4\uff09<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\">p\u503c<b><sup>[5]<\/sup><\/b><\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">0.61 (0.49, 0.74)<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\">&lt;0.0001<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u603b\u751f\u5b58<sup>[3]<\/sup><\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u53d1\u751f\u4e8b\u4ef6\u7684\u60a3\u8005\u6570\uff08%\uff09<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">107 (27)<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">121 (30)<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u603b\u751f\u5b58\u4e2d\u4f4d\u503c\uff08\u6708\uff09<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">NC<b><sup>[4]<\/sup><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">NC<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u98ce\u9669\u6bd4\uff0895% \u7f6e\u4fe1\u533a\u95f4\uff09<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\">p\u503c<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">0.86 (0.66, 1.12)<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\">0.2923<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u81f3\u4e8c\u6b21\u8fdb\u5c55\u65f6\u95f4<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u53d1\u751f\u4e8b\u4ef6\u7684\u60a3\u8005\u6570\uff08%\uff09<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">70 (18)<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">94 (24)<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u4e2d\u4f4d\u503c\uff08\u6708\uff09<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">NC<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">NC<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u98ce\u9669\u6bd4\uff0895% \u7f6e\u4fe1\u533a\u95f4\uff09<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\">p\u503c<b><sup>[5]<\/sup><\/b><\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">0.69 (0.51, 0.94)<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\">0.0184<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u81f3\u9996\u6b21\u540e\u7eed\u6cbb\u7597\u65f6\u95f4<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u53d1\u751f\u4e8b\u4ef6\u7684\u60a3\u8005\u6570\uff08%\uff09<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">183 (46)<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">221 (56)<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u4e2d\u4f4d\u503c\uff0895% CI\uff09\uff08\u6708\uff09<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">25.0 (22.2, NC)<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">19.9 (17.1, 22.0)<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u98ce\u9669\u6bd4\uff0895% \u7f6e\u4fe1\u533a\u95f4\uff09<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\">p\u503c<b><sup>[5]<\/sup><\/b><\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">0.74 (0.61, 0.90)<\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\">0.0040<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u5ba2\u89c2\u7f13\u89e3\u7387<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u53ef\u8bc4\u4f30\u60a3\u8005\u6570\uff08%\uff09<sup>[6]<\/sup><\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">161<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">160<\/span><\/p>\n<\/td>\n<td class=\"prngen5\"><\/td>\n<td class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u7f13\u89e3\u60a3\u8005\u6570\uff08%\uff09<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">94 (58)<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">77 (48)<\/span><\/p>\n<\/td>\n<td class=\"prngen5\"><\/td>\n<td class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">Odds ratio (95% CI)<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">1.60 (1.02, 2.53)<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">p\u503c<b><sup>[5]<\/sup><\/b><\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">0.0409<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>HRR \u57fa\u56e0\u7a81\u53d8\u72b6\u6001\u7684 rPFS<sup>[7]<\/sup><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen5\"><\/td>\n<td class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>HRRm<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen5\"><\/td>\n<td class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u968f\u673a\u5206\u7ec4\u60a3\u8005\u6570<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">111<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">115<\/span><\/p>\n<\/td>\n<td class=\"prngen5\"><\/td>\n<td class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u53d1\u751f\u4e8b\u4ef6\u7684\u60a3\u8005\u6570\uff08%\uff09<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">43 (39)<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">73 (63)<\/span><\/p>\n<\/td>\n<td class=\"prngen5\"><\/td>\n<td class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u4e2d\u4f4d\u503c\uff08\u6708\uff09<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">NC<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">13.9<\/span><\/p>\n<\/td>\n<td class=\"prngen5\"><\/td>\n<td class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u98ce\u9669\u6bd4\uff0895% \u7f6e\u4fe1\u533a\u95f4\uff09<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">0.50 (0.34, 0.73)<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u975e<\/b><b>HRRm<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen5\"><\/td>\n<td class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u968f\u673a\u5206\u7ec4\u60a3\u8005\u6570<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">279<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">273<\/span><\/p>\n<\/td>\n<td class=\"prngen5\"><\/td>\n<td class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u53d1\u751f\u4e8b\u4ef6\u7684\u60a3\u8005\u6570\uff08%\uff09<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">119 (43)<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">149 (55)<\/span><\/p>\n<\/td>\n<td class=\"prngen5\"><\/td>\n<td class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u4e2d\u4f4d\u503c\uff0895% CI\uff09\uff08\u6708\uff09<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">24.1 (19.6, 27.6)<\/span><\/p>\n<\/td>\n<td class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">19.0 (14.3, 21.9)<\/span><\/p>\n<\/td>\n<td class=\"prngen5\"><\/td>\n<td class=\"prngen5\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u98ce\u9669\u6bd4\uff0895% \u7f6e\u4fe1\u533a\u95f4\uff09<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">0.76 (0.60, 0.97)<\/span><\/p>\n<\/td>\n<td colspan=\"2\" class=\"prngen5\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<div>\n<table id=\"convertedTablec0ac\" cellspacing=\"0\" cellpadding=\"0\" border=\"0\" class=\"prngen2\">\n<tbody>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[1]<\/sup> \u7814\u7a76\u8005\u8bc4\u4f30\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u6570\u636e\uff1b50%\u6210\u719f\u5ea6\u7684\u4e2d\u671f\u5206\u6790\uff08796\u540d\u60a3\u8005\u4e2d\u7684 394 \u6b21\u4e8b\u4ef6\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[2]<\/sup> \u7531\u76f2\u6001\u72ec\u7acb\u4e2d\u592e\u5ba1\u67e5\u7ec4 (BICR) \u8bc4\u4f30<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[3]<\/sup> OS \u5206\u6790\u5728 29% \u7684\u6210\u719f\u5ea6\uff08796 \u540d\u60a3\u8005\u4e2d\u7684 228 \u6b21\u4e8b\u4ef6\uff09\u548c\u663e\u8457\u6027\u8fb9\u754c 0.001\uff08\u53cc\u4fa7\uff09\u8fdb\u884c\uff1b\u672a\u8fbe\u5230\u7edf\u8ba1\u5b66\u610f\u4e49\u4e0a\u7684\u663e\u8457\u6027\u3002\u751f\u5b58\u671f\u968f\u8bbf\u4ecd\u5728\u7ee7\u7eed\uff0c\u5e76\u8ba1\u5212\u8fdb\u884c\u8fdb\u4e00\u6b65\u5206\u6790\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[4]<\/sup> \u65e0\u6cd5\u7edf\u8ba1<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[5]<\/sup> \u5f88\u5c0f<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[6]<\/sup> \u53ef\u68c0\u6d4b\u75be\u75c5\u60a3\u8005\u57fa\u7ebf\u8bbe\u5b9a\u662f\u6839\u636e RECIST 1.1 \u6807\u51c6\u8fdb\u884c\uff0c\u7531\u7814\u7a76\u8005\u8bc4\u4f30\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[7]<\/sup> \u6309HRR\u72b6\u6001\u8fdb\u884c\u63a2\u7d22\u6027\u4e9a\u7ec4\u5206\u6790\u3002 PROpel\u60a3\u8005\u7684HRRm\u72b6\u6001\u662f\u7531\u4f7f\u7528\u80bf\u7624\u7ec4\u7ec7\u548c\u8840\u6d46ctDNA\u6837\u672c\u7684\u56de\u987e\u6027\u68c0\u6d4b\u7ed3\u679c\u786e\u5b9a\u7684\u3002\u5982\u679c\u901a\u8fc7\u4efb\u4e00\u6837\u672c\u68c0\u6d4b\u5230\uff08\u4e00\u4e2a\u6216\u591a\u4e2a\uff09HRR\u57fa\u56e0\u7a81\u53d8\uff0c\u5219\u5c06\u60a3\u8005\u5206\u7c7b\u4e3aHRRm\uff1b\u5982\u679c\u4efb\u4e00\u6837\u672c\u5747\u672a\u68c0\u6d4b\u5230HRR\u57fa\u56e0\u7a81\u53d8\uff0c\u5219\u5c06\u60a3\u8005\u5206\u7c7b\u4e3a\u975eHRRm\uff1b18\u540d\u60a3\u8005\u7684\u80bf\u7624\u7ec4\u7ec7\u6216ctDNA\u6837\u672c\u68c0\u6d4b\u5747\u672a\u83b7\u5f97\u6709\u6548\u7684HRR\u68c0\u6d4b\u7ed3\u679c\uff0c\u56e0\u6b64\u88ab\u6392\u9664\u5728\u4e9a\u7ec4\u5206\u6790\u4e4b\u5916\u3002\u4f7f\u7528Cox\u6bd4\u4f8b\u98ce\u9669\u6a21\u578b\u8fdb\u884c\u5206\u6790\uff0c\u5305\u62ec\u6cbb\u7597\u7ec4\u3001\u5176\u4ed6\u4e9a\u7ec4\u56e0\u7d20\u548c\u4e9a\u7ec4\u4e92\u52a8\u6cbb\u7597\u3002 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\uff08\u5927\u4e8e\u6216\u7b49\u4e8e 20% \u7684\u60a3\u8005\uff09\u662f\u8d2b\u8840\uff0845%\uff09\u3001\u6076\u5fc3\uff0828%\uff09\u548c\u75b2\u52b3\uff0828%\uff09\u30023\u7ea7\u6216\u4ee5\u4e0a\u7684AE\u4e3a\u8d2b\u8840\uff0815%\uff09\u3001\u9ad8\u8840\u538b\uff084%\uff09\u3001\u5c3f\u8def\u611f\u67d3\uff082%\uff09\u3001\u75b2\u52b3\uff081%\uff09\u3001\u98df\u6b32\u4e0b\u964d\uff081%\uff09\u3001\u5455\u5410\uff081%\uff09\u3001\u865a\u5f31\uff081%\uff09\u3001\u80cc\u75db\uff081%\uff09\uff0c\u548c\u8179\u6cfb\uff081%\uff09\u3002\u5728\u6570\u636e\u622a\u6b62\u65f6\uff0c\u7ea686%\u63a5\u53d7\u5965\u62c9\u5e15\u5229\u8054\u5408\u963f\u6bd4\u7279\u9f99\u6cbb\u7597\u4e14\u51fa\u73b0AE\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7597\u3002<\/p>\n<p>2021\u5e749\u6708\uff0c\u5728\u9884\u8bbe\u4e2d\u671f\u5206\u6790\u4e2d\uff0c\u72ec\u7acb\u6570\u636e\u76d1\u6d4b\u59d4\u5458\u4f1a\u5f97\u51fa\u7ed3\u8bba\uff1aPROpel\u8bd5\u9a8c\u8fbe\u5230\u4e86rPFS\u7684\u4e3b\u8981\u7ec8\u70b9\u3002<\/p>\n<p>\u5965\u62c9\u5e15\u5229\u5728\u7f8e\u56fd\u88ab\u6279\u51c6\u7528\u4e8e\u643a\u5e26HRR\u57fa\u56e0\u7a81\u53d8\u7684mCRPC\uff08BRCA\u7a81\u53d8\u548c\u5176\u4ed6HRR\u57fa\u56e0\u7a81\u53d8\uff09\u60a3\u8005\uff1b\u5728\u6b27\u76df\u3001\u65e5\u672c\u548c\u4e2d\u56fd\u83b7\u51c6\u7528\u4e8e\u643a\u5e26BRCA\u7a81\u53d8\u7684mCRPC\u60a3\u8005\u3002<\/p>\n<p><b>\u5173\u4e8e\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c<\/b><\/p>\n<p>\u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c\u4e0e\u9ad8\u6b7b\u4ea1\u7387\u76f8\u5173<sup>[3]<\/sup>\u3002\u524d\u5217\u817a\u764c\u8fdb\u5c55\u901a\u5e38\u7531\u5305\u62ec\u777e\u916e\u5728\u5185\u7684\u96c4\u6027\u6fc0\u7d20\u9a71\u52a8<sup>[9]<\/sup>\u3002<\/p>\n<p>\u5728mCRPC\u60a3\u8005\u4e2d\uff0c\u5c3d\u7ba1\u4f7f\u7528\u96c4\u6fc0\u7d20\u5265\u593a\u7597\u6cd5\u6765\u963b\u65ad\u96c4\u6027\u6fc0\u7d20\u7684\u4f5c\u7528\uff0c\u4f46\u524d\u5217\u817a\u764c\u4ecd\u4f1a\u8fdb\u5c55\u5e76\u6269\u6563\u5230\u8eab\u4f53\u5176\u4ed6\u90e8\u4f4d<sup>[10]<\/sup>\u3002\u5927\u7ea610-20%\u7684\u665a\u671f\u524d\u5217\u817a\u764c\u60a3\u8005\u4f1a\u5728\u4e94\u5e74\u5185\u8fdb\u5c55\u4e3a\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\uff08CRPC\uff09\uff0c\u5e76\u4e14\u5176\u4e2d\u81f3\u5c11\u670984%\u7684\u60a3\u8005\u5728\u8bca\u65ad\u4e3aCRPC\u65f6\u5df2\u7ecf\u53d1\u751f\u4e86\u8f6c\u79fb<sup>[10]<\/sup>\u3002 <\/p>\n<p>\u5728\u8bca\u65ad\u4e3aCRPC\u65f6\u6ca1\u6709\u8f6c\u79fb\u7684\u60a3\u8005\u4e2d\u670933% \u7684\u60a3\u8005\u53ef\u80fd\u5728\u4e24\u5e74\u5185\u53d1\u751f\u8f6c\u79fb<sup>[11]<\/sup>\u3002\u5c3d\u7ba1\u8fc7\u53bb\u5341\u591a\u5e74mCRPC\u6cbb\u7597\u56e0\u4e3a\u4f7f\u7528\u7d2b\u6749\u70f7\u548c\u65b0\u578b\u5185\u5206\u6ccc\u7c7b\u836f\u7269\uff08NHA\uff09\u53d6\u5f97\u4e86\u8fdb\u5c55\uff0c\u4f46\u4e00\u65e6\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u5931\u8d25\uff0c\u4e8c\u7ebf\u6cbb\u6cd5\u7684\u6548\u679c\u663e\u8457\u4e0b\u964d\uff0c\u8be5\u4eba\u7fa4\u7684\u533b\u7597\u9700\u6c42\u672a\u80fd\u5f97\u5230\u6ee1\u8db3<sup>[10],[12],[13],[14]<\/sup>\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>PROpel\u8bd5\u9a8c<\/b><\/p>\n<p>PROpel\u8bd5\u9a8c\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc3\u7684 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5728\u4e4b\u524d\u672a\u63a5\u53d7\u8fc7\u5316\u7597\u6216NHA\u7b49\u4e00\u7ebf\u6cbb\u7597\u7684mCRPC\u60a3\u8005\u4e2d\u8bc4\u4f30\u5728\u963f\u6bd4\u7279\u9f99\u7684\u57fa\u7840\u4e0a\uff0c\u5965\u62c9\u5e15\u5229\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u7684\u7597\u6548\u3001\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002<\/p>\n<p>\u4e24\u4e2a\u6cbb\u7597\u7ec4\u4e2d\u7684\u60a3\u8005\u8fd8\u5c06\u6bcf\u5929\u63a5\u53d7\u4e24\u6b21\u6cfc\u5c3c\u677e\u6216\u6cfc\u5c3c\u677e\u9f99\u3002\u4e34\u5e8a\u4e3b\u8981\u7ec8\u70b9\u662frPFS\uff0c\u6b21\u8981\u7ec8\u70b9\u5305\u62ecOS\u3001PFS2\u548cTFST\u3002<\/p>\n<p>\u6709\u5173\u8be5\u8bd5\u9a8c\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a target=\"_blank\" href=\"https:\/\/www.clinicaltrials.gov\/\" rel=\"nofollow noopener\">ClinicalTrials.gov<\/a>\u3002<\/p>\n<p><b>\u5173\u4e8e\u5965\u62c9\u5e15\u5229<\/b><\/p>\n<p>\u5965\u62c9\u5e15\u5229\u662fPARP\u6291\u5236\u5242\u7c7b\u9996\u521b\u65b0\u836f\uff0c\u662f\u9996\u4e2a\u5728\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\uff08HRR\uff09\u7f3a\u9677\u80bf\u7624\u7ec6\u80de\u4e2d\u963b\u65adDNA\u635f\u4f24\u5e94\u7b54\uff08DDR\uff09\u7684\u9776\u5411\u6cbb\u7597\u836f\u7269\uff0cHRR\u7f3a\u9677\u5305\u62ec\u5982BRCA1\/BRCA2\u7a81\u53d8\uff0c\u6216\u7531\u5176\u4ed6\u836f\u7269\uff08\u5982NHA\uff09\u5f15\u8d77\u7684\u529f\u80fd\u7f3a\u9677\u3002<\/p>\n<p>\u5965\u62c9\u5e15\u5229\u7b49PARP\u6291\u5236\u5242\u53ef\u5bfc\u81f4PARP\u88ab\u6355\u83b7\u5728\u65ad\u88c2\u7684DNA\u5355\u94fe\u5904\uff0c\u590d\u5236\u53c9\u505c\u6ede\uff0c\u51fa\u73b0DNA\u53cc\u94fe\u65ad\u88c2\uff0c\u6700\u7ec8\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u3002\u5728PROpel III \u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5965\u62c9\u5e15\u5229\u4e0e\u9776\u5411\u96c4\u6fc0\u7d20\u53d7\u4f53\uff08AR\uff09\u901a\u8def\u7684NHA\u963f\u6bd4\u7279\u9f99\u8054\u5408\u4f7f\u7528\u3002<\/p>\n<p>\u96c4\u6fc0\u7d20\u53d7\u4f53\u4fe1\u53f7\u53c2\u4e0e\u7684\u8f6c\u5f55\u8fc7\u7a0b\u5bf9\u524d\u5217\u817a\u764c\u4e2d\u7684\u80bf\u7624\u7ec6\u80de\u751f\u957f\u548c\u5b58\u6d3b\u81f3\u5173\u91cd\u8981<sup>[15],[16]<\/sup>\u3002\u4e34\u5e8a\u524d\u6a21\u578b\u5df2\u7ecf\u786e\u5b9a\u4e86PARP\u548cAR\u901a\u8def\u4e4b\u95f4\u6709\u534f\u540c\u4f5c\u7528\uff0c\u652f\u6301\u5728HRR\u7f3a\u9677\u578b\u548c\u91ce\u751f\u578b\u524d\u5217\u817a\u764c\u60a3\u8005\u4e2d\u8fdb\u884c\u5965\u62c9\u5e15\u5229\u548cNHA\uff08\u5982\u963f\u6bd4\u7279\u9f99\uff09\u7684\u8054\u5408\u6cbb\u7597<sup>[17],[18],[19]<\/sup>\u3002 <\/p>\n<p>\u6709\u7814\u7a76\u8868\u660e\u96c4\u6fc0\u7d20\u53d7\u4f53\u8f6c\u5f55\u6d3b\u6027\u53d7\u5230PARP1\u8c03\u8282\uff1b\u5965\u62c9\u5e15\u5229\u6291\u5236PARP\u6d3b\u6027\u53ef\u80fd\u4f1a\u964d\u4f4e\u96c4\u6fc0\u7d20\u53d7\u4f53\u9776\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u589e\u5f3aNHA\u7684\u6d3b\u6027<sup>[15],[18],[20]<\/sup>\u3002\u6b64\u5916\uff0c\u963f\u6bd4\u7279\u9f99\u53ef\u80fd\u4f1a\u6539\u53d8\u6216\u6291\u5236\u67d0\u4e9bHRR\u57fa\u56e0\u7684\u8f6c\u5f55\uff0c\u8fd9\u53ef\u80fd\u4f1a\u8bf1\u5bfcHRR\u529f\u80fd\u7f3a\u9677\uff0c\u589e\u5f3a\u5bf9PARP\u6291\u5236\u5242\u7684\u654f\u611f\u6027<sup>[17],[19],[21],[22]<\/sup>\u3002<\/p>\n<p>\u5965\u62c9\u5e15\u5229\u76ee\u524d\u5df2\u7ecf\u5728\u591a\u4e2a\u56fd\u5bb6\u5730\u533a\u83b7\u6279\u7528\u4e8e\u5728DDR\u901a\u8def\u4e2d\u5b58\u5728\u7f3a\u9677\u7684PARP\u4f9d\u8d56\u6027\u80bf\u7624\uff0c\u5305\u62ec\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u7528\u4e8e\u94c2\u654f\u611f\u590d\u53d1\u6027\u5375\u5de2\u764c\u7684\u7ef4\u6301\u6cbb\u7597\uff0c\u4ee5\u53ca\u4e0e\u8d1d\u4f10\u5355\u6297\u8054\u5408\u7528\u4e8e\u643a\u5e26BRCA\u7a81\u53d8\uff08BRCAm\uff09\u548c\u540c\u6e90\u91cd\u7ec4\u7f3a\u9677\uff08HRD\uff09\u665a\u671f\u5375\u5de2\u764c\u7684\u4e00\u7ebf\u7ef4\u6301\u6cbb\u7597\u3002<\/p>\n<p>\u5965\u62c9\u5e15\u5229\u8fd8\u88ab\u6279\u51c6\u7528\u4e8e\u643a\u5e26BRCAm\u3001HER2\u9634\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08\u5728\u6b27\u76df\u5305\u62ec\u5c40\u90e8\u665a\u671f\u4e73\u817a\u764c\uff09\uff1b\u7528\u4e8e\u643a\u5e26\u80da\u7cfbBRCAm\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u548c\u643a\u5e26HRR\u57fa\u56e0\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\uff08\u5728\u6b27\u76df\u548c\u65e5\u672c\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\u643a\u5e26BRCAm\uff09\u3002<\/p>\n<p>\u5965\u62c9\u5e15\u5229\u7531\u963f\u65af\u5229\u5eb7\u548c\u9ed8\u6c99\u4e1c\u8054\u5408\u5f00\u53d1\u548c\u5546\u4e1a\u63a8\u5e7f\u3002\u4ee5\u5965\u62c9\u5e15\u5229\u4e3a\u57fa\u7840\uff0c\u963f\u65af\u5229\u5eb7\u81f4\u529b\u7814\u53d1\u4e00\u7cfb\u5217\u9776\u5411DDR\u901a\u8def\u7684\u6f5c\u529b\u65b0\u836f\u3002<\/p>\n<p><b>\u5173\u4e8e\u963f\u65af\u5229\u5eb7\u4e0e\u9ed8\u6c99\u4e1c\u7684\u80bf\u7624\u6218\u7565\u5408\u4f5c<\/b><\/p>\n<p>2017\u5e747\u6708\uff0c\u963f\u65af\u5229\u5eb7\u4e0e\u9ed8\u6c99\u4e1c\uff08\u9ed8\u6c99\u4e1c\u662f\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u5c3c\u6c83\u65af\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u516c\u53f8\u5546\u53f7\uff09\u5ba3\u5e03\u5728\u5168\u7403\u8303\u56f4\u5185\u8fbe\u6210\u4e00\u9879\u80bf\u7624\u9886\u57df\u6218\u7565\u5408\u4f5c\uff0c\u5171\u540c\u5bf9\u5168\u7403\u9996\u4e2aPARP\u6291\u5236\u5242\u5965\u62c9\u5e15\u5229\u4ee5\u53ca\u6f5c\u529b\u65b0\u836fMEK\u6291\u5236\u5242\u53f8\u7f8e\u66ff\u5c3c\u5c31\u591a\u4e2a\u80bf\u7624\u9002\u5e94\u75c7\u8fdb\u884c\u4e34\u5e8a\u5f00\u53d1\u548c\u5546\u4e1a\u63a8\u5e7f\u3002<\/p>\n<p>\u53cc\u65b9\u5c06\u643a\u624b\u7814\u53d1\u5965\u62c9\u5e15\u5229\u548c\u53f8\u7f8e\u66ff\u5c3c\u4e0e\u5176\u4ed6\u6f5c\u5728\u65b0\u836f\u7684\u8054\u5408\u6cbb\u7597\u4ee5\u53ca\u5355\u836f\u6cbb\u7597\u65b9\u6848\u3002\u540c\u65f6\uff0c\u4e24\u5bb6\u516c\u53f8\u8fd8\u5c06\u72ec\u7acb\u5f00\u53d1\u5965\u62c9\u5e15\u5229\u548c\u53f8\u7f8e\u66ff\u5c3c\u4e0e\u5404\u81ea\u65d7\u4e0b\u7684PD-L1\u53caPD-1\u6291\u5236\u5242\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n<p><b>\u5173\u4e8e\u963f\u65af\u5229\u5eb7\u80bf\u7624\u9886\u57df\u7684\u7814\u7a76<\/b><\/p>\n<p>\u963f\u65af\u5229\u5eb7\u6b63\u5f15\u9886\u7740\u80bf\u7624\u9886\u57df\u7684\u4e00\u573a\u9769\u547d\uff0c\u81f4\u529b\u63d0\u4f9b\u591a\u5143\u5316\u7684\u80bf\u7624\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u79d1\u5b66\u63a2\u7d22\u80bf\u7624\u9886\u57df\u7684\u590d\u6742\u6027\uff0c\u53d1\u73b0\u3001\u7814\u53d1\u5e76\u5411\u60a3\u8005\u63d0\u4f9b\u6539\u53d8\u751f\u547d\u7684\u836f\u7269\u3002<\/p>\n<p>\u963f\u65af\u5229\u5eb7\u4e13\u6ce8\u4e8e\u6700\u5177\u6311\u6218\u6027\u7684\u80bf\u7624\u75be\u75c5\uff0c\u901a\u8fc7\u6301\u7eed\u4e0d\u65ad\u7684\u521b\u65b0\uff0c\u963f\u65af\u5229\u5eb7\u5df2\u7ecf\u5efa\u7acb\u4e86\u884c\u4e1a\u9886\u5148\u7684\u591a\u5143\u5316\u7684\u4ea7\u54c1\u7ec4\u5408\u548c\u7ba1\u7ebf\uff0c\u6301\u7eed\u63a8\u52a8\u533b\u7597\u5b9e\u8df5\u53d8\u9769\uff0c\u6539\u53d8\u60a3\u8005\u4f53\u9a8c\u3002<\/p>\n<p>\u963f\u65af\u5229\u5eb7\u4ee5\u671f\u91cd\u65b0\u5b9a\u4e49\u764c\u75c7\u6cbb\u7597\u5e76\u5728\u672a\u6765\u653b\u514b\u764c\u75c7\u3002<\/p>\n<p><b>\u5173\u4e8e\u963f\u65af\u5229\u5eb7<\/b><\/p>\n<p>\u963f\u65af\u5229\u5eb7\uff08LSE\/STO\/Nasdaq: AZN\uff09\u662f\u4e00\u5bb6\u79d1\u5b66\u81f3\u4e0a\u7684\u5168\u7403\u6027\u751f\u7269\u5236\u836f\u4f01\u4e1a\uff0c\u4e13\u6ce8\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u53ca\u8425\u9500\u5904\u65b9\u7c7b\u836f\u54c1\uff0c\u91cd\u70b9\u5173\u6ce8\u80bf\u7624\u3001\u7f55\u89c1\u75c5\u548c\u751f\u7269\u533b\u836f\uff0c\u5305\u62ec\u5fc3\u8840\u7ba1\u3001\u80be\u810f\u53ca\u4ee3\u8c22\u3001\u547c\u5438\u53ca\u514d\u75ab\u3002\u963f\u65af\u5229\u5eb7\u5168\u7403\u603b\u90e8\u4f4d\u4e8e\u82f1\u56fd\u5251\u6865\uff0c\u4e1a\u52a1\u904d\u5e03\u4e16\u754c100\u591a\u4e2a\u56fd\u5bb6\uff0c\u521b\u65b0\u836f\u7269\u60e0\u53ca\u5168\u7403\u6570\u767e\u4e07\u60a3\u8005\u3002\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a target=\"_blank\" href=\"http:\/\/www.astrazeneca.com\/\" rel=\"nofollow noopener\">www.astrazeneca.com<\/a>\u3002<\/p>\n<p><b>\u58f0\u660e<\/b><\/p>\n<p><b>\u672c\u6587\u6d89\u53ca\u7814\u7a76\u4e2d\u7684\u836f\u54c1\u7528\u6cd5\u5c1a\u672a\u5728\u4e2d\u56fd\u83b7\u6279\u9002\u5e94\u75c7\uff0c\u963f\u65af\u5229\u5eb7\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u88ab\u6279\u51c6\u7684\u836f\u54c1\u4f7f\u7528\u3002<\/b><\/p>\n<\/p>\n<hr \/>\n<div>\n<table id=\"convertedTable9568\" cellspacing=\"0\" cellpadding=\"0\" border=\"0\" class=\"prngen2\">\n<tbody>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>References<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[1].<\/sup> IARC. Cancer Today \u2013 Estimated number of new cases in 2020, worldwide, both sexes, all ages. Available at <a target=\"_blank\" href=\"https:\/\/gco.iarc.fr\/today\/home\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/gco.iarc.fr\/today\/home<\/a>. Accessed January 2022.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[2].<\/sup> Moreira D, et al. Predicting Time From Metastasis to Overall Survival in Castration-Resistant Prostate Cancer: Results From SEARCH. Clin Genitourin Cancer. 2017;15(1):60-66.e2.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[3].<\/sup> Chowdhury S, et al. Real-world outcomes in first-line treatment of metastatic castration-resistant prostate cancer: the prostate cancer registry. Target Oncol. 2020;15(3):301-15.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[4].<\/sup> George DJ, et al. Treatment Patterns and Outcomes in Patients With Metastatic Castration-resistant Prostate Cancer in a Real-world Clinical Practice Setting in the United States. Clin Genitourin Cancer. 2020; 18(4):284-294.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[5].<\/sup> de Bono JS, et al. Subsequent Chemotherapy and Treatment Patterns After Abiraterone Acetate in Patients with Metastatic Castration-resistant Prostate Cancer: Post Hoc Analysis of COU-AA-302. Eur Urol. 2017;71(4):656-664.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[6].<\/sup> Ryan CJ, et al. Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study. Lancet Oncol. 2015;16(2):152-160.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[7].<\/sup> Beer TM, et al. Enzalutamide in Men with Chemotherapy-na&iuml;ve Metastatic Castration-resistant Prostate Cancer: Extended Analysis of the Phase 3 PREVAIL Study. Eur Urol. 2017;71(2):151-154<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[8].<\/sup> Mateo, J, et al (2015). DNA-repair defects and olaparib in metastatic prostate cancer. The New England Journal of Medicine, 373(18), pp.1697 &#8211; 1708.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[9].<\/sup> Cancer.Net. Treatment of metastatic castration-resistant prostate cancer. Available at <a target=\"_blank\" href=\"http:\/\/www.cancer.net\/research-and-advocacy\/asco-care-and-treatment-recommendations-patients\/treatment-metastatic-castration-resistant-prostate-cancer\" class=\"prnews_a\" rel=\"nofollow noopener\">www.cancer.net\/research-and-advocacy\/asco-care-and-treatment-recommendations-patients\/treatment-metastatic-castration-resistant-prostate-cancer<\/a>. Accessed January 2022.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[10].<\/sup> Kirby, M, et al. Characterising the castration-resistant prostate cancer population: a systematic review. International Journal of Clinical Practice, 2021;65(11):1180-1192.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[11].<\/sup> Smith MR, et al. Natural history of rising serum prostate-specific antigen in men with castrate nonmetastatic prostate cancer. J Clin Oncol. 2005;23(13):2918-25.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[12].<\/sup> UroToday. What is Changing in Advanced Prostate Cancer? Available at <a target=\"_blank\" href=\"https:\/\/www.urotoday.com\/journal\/everyday-urology-oncology-insights\/articles\/122176-what-is-changing-in-advanced-prostate-cancer.html\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/www.urotoday.com\/journal\/everyday-urology-oncology-insights\/articles\/122176-what-is-changing-in-advanced-prostate-cancer.html<\/a>. Accessed January 2022.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[13].<\/sup> Liu J, et al. Second-line Hormonal Therapy for the Management of Metastatic Castration-resistant Prostate Cancer: a Real-World Data Study Using a Claims Database. Scientific Report. 2020;10(4240):2020.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[14].<\/sup> UroToday. Beyond First-line Treatment of Metastatic Castrate-resistant Prostate Cancer. Available at <a target=\"_blank\" href=\"https:\/\/www.urotoday.com\/library-resources\/mcrpc-treatment\/114592-beyond-first-line-treatment-of-metastatic-castrate-resistant-prostate-cancer.html\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/www.urotoday.com\/library-resources\/mcrpc-treatment\/114592-beyond-first-line-treatment-of-metastatic-castrate-resistant-prostate-cancer.html<\/a>. Accessed January 2022.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[15].<\/sup> Schiewer MJ, et al. Dual roles of PARP-1 promote cancer growth and progression. Cancer Discov. 2012;2(12):1134-1149.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[16].<\/sup> Schiewer MJ &amp; Knudsen KE. AMPed up to treat prostate cancer: novel AMPK activators emerge for cancer therapy. EMBO Mol Med. 2014;6(4):439-441.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[17].<\/sup> Li L, et al. Androgen receptor inhibitor\u2013induced \u201cBRCAness\u201d and PARP inhibition are synthetically lethal for castration-resistant prostate cancer. Sci Signal. 2017; 10(480):eaam7479.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[18].<\/sup> Polkinghorn WR, et al. Androgen receptor signaling regulates DNA repair in prostate cancers. Cancer Discov. 2013;3(11):1245-1253.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[19].<\/sup> Asim M, et al. Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer. Nat Commun. 2017;374(8).<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[20].<\/sup> Ju B-G, et al. A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science. 2006;312(5781):1798-1802.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[21].<\/sup> Goodwin JF, et al. A hormone-DNA repair circuit governs the response to genotoxic insult. Cancer Discov. 2013;3(11):1254-1271.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[22].<\/sup> Tarish FL, et al. Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair. Sci Transl Med. 2015; 7(312):312re11.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e0e\u5355\u7528\u963f\u6bd4\u7279\u9f99\u6cbb\u7597\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u8054\u5408\u7597\u6cd5\u8010\u53d7\u6027\u826f\u597d\uff0c\u60a3\u8005\u80fd\u591f\u4fdd\u6301\u751f\u6d3b\u8d28\u91cf\u3002 PROpel III \u671f\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u65e0\u8bba\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\u57fa\u56e0\u7a81\u53d8\uff0c\u60a3\u8005\u5747\u53ef\u4ece\u8054\u5408\u7597\u6cd5\u4e2d\u83b7\u76ca\u3002 \u4e0a\u6d772022\u5e742\u670817\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; PROpel III \u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u9633\u6027\u7ed3\u679c\u8868\u660e\uff0c\u963f\u65af\u5229\u5eb7\uff08AstraZeneca\uff09\u548c\u9ed8\u6c99\u4e1c\uff08MSD\uff09\u5408\u4f5c\u5f00\u53d1\u7684\u5965\u62c9\u5e15\u5229\uff08\u5546\u54c1\u540d\u5229\u666e\u5353\uff09\u4e0e\u963f\u6bd4\u7279\u9f99\u8054\u5408\u7528\u836f\uff0c\u4e00\u7ebf\u6cbb\u7597\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\uff08mCRPC\uff09\u60a3\u8005\uff0c\u4e0e\u76ee\u524d\u7684\u6807\u51c6\u6cbb\u7597\u963f\u6bd4\u7279\u9f99\u76f8\u6bd4\uff0c\u65e0\u8bba\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\uff08HRR\uff09\u57fa\u56e0\u7a81\u53d8\u72b6\u6001\uff0c\u5f71\u50cf\u5b66\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08rPFS\uff09\u8fbe\u5230\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u6539\u5584\u3002&nbsp;&nbsp; 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