{"id":62541,"date":"2022-02-17T07:00:00","date_gmt":"2022-02-17T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022021707000062541"},"modified":"2022-02-17T17:56:40","modified_gmt":"2022-02-17T09:56:40","slug":"%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83ibi306%ef%bc%88pcsk-9%e6%8a%91%e5%88%b6%e5%89%82%ef%bc%89%e7%9a%84%e4%b8%a4%e9%a1%b9%e5%85%b3%e9%94%ae%e6%b3%a8%e5%86%8c%e4%b8%b4%e5%ba%8a","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022021707000062541","title":{"rendered":"\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03IBI306\uff08PCSK-9\u6291\u5236\u5242\uff09\u7684\u4e24\u9879\u5173\u952e\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9"},"content":{"rendered":"

\u7f8e\u56fd\u65e7\u91d1\u5c71\u548c\u4e2d\u56fd\u82cf\u5dde2022\u5e742\u670817\u65e5 \/\u7f8e\u901a\u793e\/ — \u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff1a\u7531\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u91cd\u7ec4\u5168\u4eba\u6e90\u6297\u524d\u86cb\u767d\u8f6c\u5316\u9176\u67af\u8349\u6eb6\u83cc\u7d209\uff08PCSK-9\uff09\u5355\u514b\u9686\u6297\u4f53\uff08\u7814\u53d1\u4ee3\u53f7\uff1aIBI306\uff09\u7684\u4e24\u9879\u4e2d\u56fd\u5173\u952e\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76 —<\/span> CREDIT-1\u7814\u7a76\uff08\u6cbb\u7597\u975e\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7[non-FH]\u5408\u5e76\u9ad8\u5371\/\u6781\u9ad8\u5371\u5fc3\u8840\u7ba1\u98ce\u9669\uff09\u548cCREDIT-4\u7814\u7a76\uff08\u6cbb\u7597\u975e\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7[non-FH]\u548c\u6742\u5408\u5b50\u578b\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7[HeFH]\uff09\uff0c\u5747\u8fbe\u5230\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u3002CREDIT-1\u548cCREDIT-4\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u5c06\u5728\u672a\u6765\u7684\u56fd\u9645\u5b66\u672f\u4f1a\u8bae\u4e0a\u4e88\u4ee5\u516c\u5e03\u3002<\/p>\n

\u622a\u81f3\u76ee\u524d\uff0cIBI306\u4e09\u9879\u4e3b\u8981\u5173\u952e\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\u5747\u5df2\u5b8c\u6210\u4e14\u5747\u987a\u5229\u8fbe\u5230\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\uff0c\u5176\u4e2dCREDIT-2\u7814\u7a76\uff08\u6cbb\u7597\u6742\u5408\u5b50\u578b\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7[HeFH]\uff09\u5df2\u4e8e2021\u5e748\u6708\u8fbe\u5230\u4e34\u5e8a\u7ec8\u70b9\u3002\u4fe1\u8fbe\u751f\u7269\u8ba1\u5212\u5c31\u9012\u4ea4IBI306\u7528\u4e8e\u539f\u53d1\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u548c\u6df7\u5408\u578b\u8840\u8102\u5f02\u5e38\u7684\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u4e0e\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u8fdb\u884c\u6c9f\u901a\u3002<\/p>\n

CREDIT-1\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5728\u4e2d\u56fd\u975e\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7(non-FH)\u5408\u5e76\u9ad8\u5371\/\u6781\u9ad8\u5371\u5fc3\u8840\u7ba1\u98ce\u9669\u60a3\u8005\u4e2d\uff0cIBI306\u5404\u5242\u91cf\u7ec4\u8fde\u7eed\u6cbb\u759748\u5468\u540e\uff0c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\uff08LDL-C\uff09\u76f8\u5bf9\u57fa\u7ebf\u4e0b\u964d\u6c34\u5e73\uff0c\u8f83\u5b89\u6170\u5242\u7ec4\u5747\u6709\u663e\u8457\u6539\u5584\uff08450mg Q4W\u7ec4\uff1a\u6700\u5c0f\u4e8c\u4e58\u4f30\u8ba1\u7ec4\u95f4\u5dee\u5f02\u4e3a-65.04%\uff0c97.5%\u7f6e\u4fe1\u533a\u95f4\u4e3a-70.22%~-59.86%\uff0cP<0.0001\uff1b600mg Q6W\u7ec4\uff1a\u6700\u5c0f\u4e8c\u4e58\u4f30\u8ba1\u7ec4\u95f4\u5dee\u5f02\u4e3a-57.31%\uff0c97.5%\u7f6e\u4fe1\u533a\u95f4\u4e3a-63.95%~-50.68%\uff0cP<0.0001\uff09\u3002<\/span> <\/p>\n

CREDIT-4\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5728\u4e2d\u56fdnon-FH\u548cHeFH\u60a3\u8005\u4e2d\uff0cIBI306\u6cbb\u759712\u5468\u540eLDL-C\u76f8\u5bf9\u57fa\u7ebf\u4e0b\u964d\u6c34\u5e73\u8f83\u5b89\u6170\u5242\u7ec4\u4e5f\u6709\u660e\u663e\u6539\u5584\uff08450mg Q4W\u7ec4\u6700\u5c0f\u4e8c\u4e58\u4f30\u8ba1\u7ec4\u95f4\u5dee\u5f02\u4e3a-63.02%\uff0c95%\u7f6e\u4fe1\u533a\u95f4\u4e3a-66.48%~-59.56%\uff0cP<0.0001\uff09\u3002<\/span>\u4e0a\u8ff0\u4e24\u9879\u7814\u7a76\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\uff0cIBI306\u603b\u4f53\u5b89\u5168\u6027\u826f\u597d\uff0c\u4e0e\u5df2\u4e0a\u5e02\u540c\u7c7b\u4ea7\u54c1\u5b89\u5168\u6027\u7279\u5f81\u76f8\u4f3c\u3002 <\/p>\n

\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u662f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3001\u51a0\u5fc3\u75c5\u3001\u8111\u5352\u4e2d\u7b49\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u72ec\u7acb\u98ce\u9669\u56e0\u7d20\uff0c\u4e25\u91cd\u5a01\u80c1\u4eba\u4eec\u5065\u5eb7\uff0c\u4e2d\u56fd\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u7684\u60a3\u75c5\u7387\u9ad8\u8fbe26.3%\u3002\u4ed6\u6c40\u7c7b\u836f\u7269\u4f9d\u7136\u662f\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u7684\u4e3b\u8981\u6cbb\u7597\u65b9\u6cd5\uff0c\u4f46\u4e0d\u5c11\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u7597\u540e\u4ecd\u65e0\u6cd5\u8fbe\u5230LDL-C\u964d\u4f4e\u7684\u6cbb\u7597\u76ee\u6807\uff0c\u800c\u4e14\u56e0\u75be\u75c5\u672c\u8eab\u5b58\u5728\u79cd\u65cf\u5dee\u5f02\u6027\uff0c\u4e2d\u56fd\u4eba\u7fa4\u63a5\u53d7\u9ad8\u5f3a\u5ea6\u4ed6\u6c40\u6cbb\u7597\u5b58\u5728\u5b89\u5168\u6027\u987e\u8651\u3002<\/p>\n

PCSK-9\u6291\u5236\u5242\u4f5c\u4e3a\u8fd1\u5e74\u6765\u80fd\u5f3a\u6548\u964d\u4f4eLDL-C\u6c34\u5e73\u4e14\u5b89\u5168\u6027\u826f\u597d\u7684\u65b0\u578b\u6cbb\u7597\u65b9\u6848\uff0c\u9010\u6e10\u5f97\u5230\u4e34\u5e8a\u533b\u751f\u7684\u8ba4\u53ef\uff0c\u4f46\u4e2d\u56fd\u5e02\u573a\u76ee\u524d\u4ec5\u6709\u8fdb\u53e3\u54c1\u79cd\uff0c\u7ecf\u6d4e\u6027\u548c\u4fbf\u5229\u6027\u5b58\u5728\u4e00\u5b9a\u5c40\u9650<\/span>\u3002IBI306\u662f\u4fe1\u8fbe\u81ea\u4e3b\u5f00\u53d1\u7684\u521b\u65b0\u578b\u751f\u7269\u836f\uff0c\u662f\u56fd\u5185\u7387\u5148\u5f00\u5c55\u957f\u671f\u3001\u5927\u89c4\u6a21\u3001\u968f\u673a\u53cc\u76f2\u4e09\u671f\u4e34\u5e8a\u7814\u7a76\u7684PCSK-9\u6291\u5236\u5242\uff0c\u5e76\u63a2\u7d22\u548c\u4f18\u5316\u4e86\u957f\u95f4\u9694\u7ed9\u836f\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n

CREDIT-1\u548cCREDIT-4\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u5317\u4eac\u5927\u5b66\u7b2c\u4e00\u533b\u9662\u970d\u52c7\u6559\u6388<\/b>\u8868\u793a\uff1a\u201cCREDIT-1\u548cCREDIT-4\u4e24\u9879\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\u7684\u7ed3\u679c\u975e\u5e38\u4ee4\u4eba\u9f13\u821e\u3002\u503c\u5f97\u6307\u51fa\u7684\u662fIBI306\u5728CREDIT-1\u4e2d\u5b9e\u73b0\u4e86\u957f\u95f4\u9694\u7ed9\u836f\uff0c\u4e14\u7814\u7a76\u6570\u636e\u663e\u793a\u80fd\u591f\u957f\u671f\u663e\u8457\u964d\u4f4e\u4e2d\u56fd\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u4eba\u7fa4\u7684LDL-C\u6c34\u5e73\uff0c<\/span>\u4e3a\u4e34\u5e8a\u6cbb\u7597\u5b9e\u73b0\u66f4\u597d\u7684\u4f9d\u4ece\u6027\u5e26\u6765\u4e86\u53ef\u80fd\u3002\u6211\u4eec\u671f\u5f85IBI306\u65e9\u65e5\u4e3a\u4e2d\u56fd\u5e7f\u5927\u7684\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u60a3\u8005\u5e26\u6765\u66f4\u53cb\u597d\u548c\u53ef\u53ca\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/span><\/p>\n

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CREDIT-1\u7814\u7a76\u662f\u4e00\u9879\u8bc4\u4f30\u4e2d\u56fd\u975e\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff08\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u5408\u5e76\u9ad8\u5371\/\u6781\u9ad8\u5371\u5fc3\u8840\u7ba1\u98ce\u9669\uff09\u60a3\u8005\u5e94\u7528IBI306\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff08ClinicalTrials.gov, NCT04289285\uff09\u3002\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\u4e3a\u6cbb\u759748\u5468LDL-C\u8f83\u57fa\u7ebf\u4e0b\u964d\u767e\u5206\u7387\u3002<\/p>\n

CREDIT-2\u7814\u7a76\u662f\u4e00\u9879\u8bc4\u4f30\u4e2d\u56fd\u6742\u5408\u5b50\u578b\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u53d7\u8bd5\u8005\u5e94\u7528IBI306\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167III\u671f\u4e34\u5e8a\u7814\u7a76\uff08ClinicalTrials.gov, NCT04759534\uff09\u3002\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u4e3a\u6cbb\u759712\u5468LDL-C\u8f83\u57fa\u7ebf\u4e0b\u964d\u767e\u5206\u7387\u3002<\/p>\n

CREDIT-4\u7814\u7a76\u662f\u4e00\u9879\u8bc4\u4f30\u4e2d\u56fd\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff08\u5305\u542b\u975e\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u548c\u6742\u5408\u5b50\u578b\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff09\u60a3\u8005\u5e94\u7528IBI306\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff08ClinicalTrials.gov, NCT04709536\uff09\u3002\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\u4e3a\u6cbb\u759712\u5468LDL-C\u8f83\u57fa\u7ebf\u4e0b\u964d\u767e\u5206\u7387\u3002<\/p>\n

\u5173\u4e8e\u9ad8\u80c6\u56fa\u9187\u8840\u75c7<\/b><\/p>\n

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\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n

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