{"id":62379,"date":"2022-02-15T11:33:00","date_gmt":"2022-02-15T04:33:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022021511330062379"},"modified":"2022-02-15T18:01:03","modified_gmt":"2022-02-15T10:01:03","slug":"%e5%8f%af%e5%8f%8a%e6%80%a7%e9%ab%98%e7%9a%84%e5%86%bb%e5%b9%b2%e5%89%82%e5%9e%8bmrna-lnp%e6%96%b0%e5%86%a0%e7%96%ab%e8%8b%97%e5%9c%a8%e4%b8%b4%e5%ba%8a%e5%89%8d%e7%a0%94%e7%a9%b6%e4%b8%ad%e8%a1%a8","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022021511330062379","title":{"rendered":"\u53ef\u53ca\u6027\u9ad8\u7684\u51bb\u5e72\u5242\u578bmRNA-LNP\u65b0\u51a0\u75ab\u82d7\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u8868\u73b0\u51fa\u826f\u597d\u7684\u7a33\u5b9a\u6027\u548c\u514d\u75ab\u539f\u6027"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" title=\"logo\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/Recbio_Logo-2.jpg\" 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href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.02.10.479867v1\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.biorxiv.org\/content\/10.1101\/2022.02.10.479867v1<\/a>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u745e\u79d1\u751f\u7269<\/strong><\/p>\n<p>\u745e\u79d1\u751f\u7269\u662f\u4e00\u5bb6\u59cb\u521b\u4e8e 2011 \u5e74\u7684\u521b\u65b0\u578b\u75ab\u82d7\u516c\u53f8\uff0c\u4ee5&ldquo;\u521b\u5236\u4e00\u6d41\u75ab\u82d7\uff0c\u5b88\u62a4\u4eba\u7c7b\u5065\u5eb7&rdquo;\u4e3a\u4f7f\u547d\u613f\u666f\uff0c\u5df2\u5efa\u7acb\u5148\u8fdb\u7684\u65b0\u578b\u4f50\u5242\u3001\u86cb\u767d\u5de5\u7a0b\u548c\u514d\u75ab\u8bc4\u4ef7\u4e09\u5927\u6280\u672f\u5e73\u53f0\uff0c\u62e5\u6709 HPV 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target=\"_blank\">https:\/\/www.recbio.cn\/<\/a><\/p>\n<p><strong>\u5173\u4e8e\u745e\u79d1\u5409\u751f\u7269<\/strong><\/p>\n<p>\u745e\u79d1\u5409\u751f\u7269\u6210\u7acb\u4e8e2021\u5e74\uff0c\u662f\u745e\u79d1\u751f\u7269\u7684\u63a7\u80a1\u5b50\u516c\u53f8\u3002\u745e\u79d1\u5409\u751f\u7269\u662f\u4e00\u5bb6\u62e5\u6709\u5168\u7403\u9886\u5148mRNA\u75ab\u82d7\u5e73\u53f0\u6280\u672f\u53ca\u65b0\u578b\u4f50\u5242\u6280\u672f\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\u3002\u516c\u53f8\u7531\u6c5f\u82cf\u745e\u79d1\u751f\u7269\u6280\u672f\u80a1\u4efd\u6709\u9650\u516c\u53f8\u4ee5\u53ca\u6df1\u5733\u5e02\u745e\u5409\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u5408\u8d44\u6210\u7acb\uff0c\u603b\u90e8\u4f4d\u4e8e\u6b66\u6c49\u3002\u4e24\u5bb6\u6bcd\u516c\u53f8\u5404\u81ea\u62e5\u6709\u7684\u4e16\u754c\u9886\u5148\u7684\u539f\u521b\u6280\u672f\u5728\u745e\u79d1\u5409\u751f\u7269\u4e2d\u5f3a\u5f3a\u878d\u5408\uff0c\u4f18\u52bf\u4e92\u8865\u3002\u745e\u79d1\u5409\u751f\u7269\u79c9\u627f&ldquo;\u514d\u75ab\u5b66\u62e5\u62b1\u4e2d\u5fc3\u6cd5\u5219&rdquo;\u7684\u7b56\u7565\u81ea\u4e3b\u7814\u53d1\u5f00\u53d1\u4e86mRNA\u75ab\u82d7\u7684\u8bbe\u8ba1\u3001\u5408\u6210\u53ca\u8bc4\u4ef7\u6240\u9700\u7684\u5e73\u53f0\u578b\u6280\u672f\uff0c\u5e76\u5c06\u8be5\u7c7b\u6280\u672f\u8fd0\u7528\u4e8e\u5404\u7c7b\u4f20\u67d3\u75c5\u75ab\u82d7\u5f00\u53d1\u8fd9\u4e00\u5177\u6709\u5de8\u5927\u5e02\u573a\u524d\u666f\u548c\u4e34\u5e8a\u4ef7\u503c\u7684\u9886\u57df\u3002<\/p>\n<p><strong>\u524d\u77bb\u6027\u8bf4\u660e<\/strong><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528&ldquo;\u9884\u671f&rdquo;\u3001&ldquo;\u76f8\u4fe1&rdquo;\u3001&ldquo;\u9884\u6d4b&rdquo;\u3001&ldquo;\u671f\u671b&rdquo;\u3001&ldquo;\u6253\u7b97&rdquo;\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u5e76\u65e0\u4e49\u52a1\u4e0d\u65ad\u5730\u66f4\u65b0\u8fd9\u4e9b\u9884\u6d4b\u6027\u9648\u8ff0\u3002<\/p>\n<p>\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n<p>&nbsp;<\/p>\n<div 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<a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2022021511330062379\">Read 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