{"id":61739,"date":"2022-01-28T18:06:00","date_gmt":"2022-01-28T11:06:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022012818060061739"},"modified":"2022-01-29T17:56:18","modified_gmt":"2022-01-29T09:56:18","slug":"%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9e%e5%ae%a3%e5%b8%83%e7%99%be%e6%82%a6%e6%b3%bd%ef%bc%88%e6%b3%bd%e5%b8%83%e6%9b%bf%e5%b0%bc%ef%bc%89%e6%b2%bb%e7%96%97%e6%85%a2%e6%80%a7%e6%b7%8b%e5%b7%b4","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022012818060061739","title":{"rendered":"\u767e\u6d4e\u795e\u5dde\u5ba3\u5e03\u767e\u60a6\u6cfd\u00ae\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u6cbb\u7597\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\u5df2\u5728\u4e2d\u56fd\u53d7\u7406\u5e76\u83b7\u5f97\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a"},"content":{"rendered":"<p><p><span 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+ R\uff09\u65b9\u6848\u8fdb\u884c\u4e86\u5bf9\u6bd4\uff0c\u5176\u7814\u7a76\u7ed3\u679c\u652f\u6301\u4e86\u672c\u6b21sNDA\u7684\u7533\u62a5\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u663e\u793a\uff0c\u57fa\u4e8e\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRC\uff09\u8bc4\u4f30\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728PFS\u65b9\u9762\u5c55\u73b0\u4e86\u5bf9\u6bd4B + R\u65b9\u6848\u7684\u4f18\u6548\u6027\u3002\u4e2d\u4f4d\u968f\u8bbf26.15\u4e2a\u6708\u65f6\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u7ec4\u768424\u4e2a\u6708PFS\u4e3a85.5%\uff0895% CI\uff1a80.1\uff0c89.6\uff09\uff0cB + R\u7ec4\u4e3a69.5%\uff0895% CI\uff1a62.4\uff0c75.5\uff09\uff0c\u98ce\u9669\u6bd4\uff08HR\uff09\u4e3a0.42\uff0895% CI\uff1a0.27\uff0c0.63\uff09\uff0c<i>p<\/i>&nbsp;&lt;&nbsp;0.0001\u3002\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u60a3\u8005\u4e2d\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u5176\u5728\u5e7f\u6cdb\u7684\u4e34\u5e8a\u9879\u76ee\u4e2d\u7684\u8868\u73b0\u4e00\u81f4\uff0c\u5305\u62ec\u623f\u98a4\u7684\u53d1\u751f\u7387\u8f83\u4f4e\u3002<\/p>\n<p><b>\u5173\u4e8e\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5<\/b><\/p>\n<p>\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u662f\u6210\u4eba\u4e2d\u6700\u5e38\u89c1\u7684\u4e00\u79cd\u767d\u8840\u75c5\uff0c2017\u5e74\uff0c\u5168\u7403\u7ea6\u6709114,000\u4f8bCLL\u65b0\u53d1\u75c5\u4f8b\u3002CLL\u4f1a\u5f71\u54cd\u9aa8\u9ad3\u4e2d\u7684\u767d\u7ec6\u80de\u6216\u6dcb\u5df4\u7ec6\u80de\uff0c\u9aa8\u9ad3\u4e2d\u764c\u7ec6\u80de\uff08\u767d\u8840\u75c5\uff09\u7684\u589e\u6b96\u4f1a\u5bfc\u81f4\u7ec6\u80de\u6297\u611f\u67d3\u7684\u80fd\u529b\u964d\u4f4e\uff0c\u5e76\u6269\u6563\u81f3\u8840\u6db2\uff0c\u4ece\u800c\u7d2f\u53ca\u8eab\u4f53\u5176\u4ed6\u90e8\u4f4d\uff0c\u5305\u62ec\u6dcb\u5df4\u7ed3\u3001\u809d\u810f\u548c\u813e\u810f\u3002<sup><span id=\"spanHghlt1942\">[1]\u3001[2]\u3001[3]<\/span><\/sup>\u5df2\u77e5BTK\u901a\u8def\u662f\u6076\u6027B\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u7684\u91cd\u8981\u4ecb\u8d28\uff0c\u80fd\u591f\u81f4\u4f7fCLL\u7684\u53d1\u751f\u3002<sup><span id=\"spanHghlt44c0\">[4]<\/span><\/sup>\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09\u662f\u4e00\u79cd\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c\u4e3b\u8981\u5f71\u54cd\u5f71\u54cd\u514d\u75ab\u7cfb\u7edf\u4e2dB\u6dcb\u5df4\u7ec6\u80de\u3002SLL\u4e0eCLL\u6709\u8bb8\u591a\u76f8\u4f3c\u4e4b\u5904\uff0c\u4f46\u5176\u80bf\u7624\u7ec6\u80de\u591a\u89c1\u4e8e\u6dcb\u5df4\u7ed3\u4e2d\u3002<sup><span id=\"spanHghlt2c38\">[5]<\/span><\/sup><\/p>\n<p><b>\u5173\u4e8e\u767e\u60a6\u6cfd<\/b><b><sup>&reg;<\/sup><\/b><\/p>\n<p>\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u662f\u4e00\u6b3e\u7531\u767e\u6d4e\u795e\u5dde\u79d1\u5b66\u5bb6\u81ea\u4e3b\u7814\u53d1\u7684\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u76ee\u524d\u6b63\u5728\u5168\u7403\u8fdb\u884c\u5e7f\u6cdb\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9879\u76ee\uff0c\u4f5c\u4e3a\u5355\u836f\u548c\u4e0e\u5176\u4ed6\u7597\u6cd5\u8fdb\u884c\u8054\u5408\u7528\u836f\u6cbb\u7597\u591a\u79cdB\u7ec6\u80de\u6076\u6027\u80bf\u7624\u3002\u7531\u4e8e\u65b0\u7684BTK\u4f1a\u5728\u4eba\u4f53\u5185\u4e0d\u65ad\u5408\u6210\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u7684\u8bbe\u8ba1\u901a\u8fc7\u4f18\u5316\u751f\u7269\u5229\u7528\u5ea6\u3001\u534a\u8870\u671f\u548c\u9009\u62e9\u6027\uff0c\u5b9e\u73b0\u5bf9BTK\u86cb\u767d\u5b8c\u5168\u3001\u6301\u7eed\u7684\u6291\u5236\u3002\u51ed\u501f\u4e0e\u5176\u4ed6\u83b7\u6279BTK\u6291\u5236\u5242\u5b58\u5728\u5dee\u5f02\u5316\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u80fd\u5728\u591a\u4e2a\u75be\u75c5\u76f8\u5173\u7ec4\u7ec7\u4e2d\u6291\u5236\u6076\u6027B\u7ec6\u80de\u589e\u6b96\u3002<\/p>\n<p>\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5df2\u572843\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u83b7\u5f9720\u9879\u6279\u51c6\uff1a<\/p>\n<ul type=\"disc\">\n<li>2019\u5e7411\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005<sup>*<\/sup>\uff1b <\/li>\n<li>2020\u5e746\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005<sup>**<\/sup>\uff1b <\/li>\n<li>2020\u5e746\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u6216\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09\u60a3\u8005<sup>**<\/sup>\uff1b <\/li>\n<li>2021\u5e741\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4ee5\u8272\u5217\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e742\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u963f\u62c9\u4f2f\u8054\u5408\u914b\u957f\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e743\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u52a0\u62ff\u5927\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e746\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u60a3\u8005<sup>**<\/sup>\uff1b <\/li>\n<li>2021\u5e747\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u52a0\u62ff\u5927\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e747\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u667a\u5229\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e748\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u5df4\u897f\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e748\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e749\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u542b\u6297CD20\u6297\u4f53\u6cbb\u7597\u65b9\u6848\u7684\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff08MZL\uff09\u6210\u4eba\u60a3\u8005<sup>*<\/sup>\uff1b <\/li>\n<li>2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u65b0\u52a0\u5761\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u6fb3\u5927\u5229\u4e9a\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u60a3\u8005\uff0c\u6216\u4f5c\u4e3a\u4e00\u7ebf\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u4e0d\u9002\u5408\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u7684\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u6fb3\u5927\u5229\u4e9a\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4fc4\u7f57\u65af\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e7411\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u6c99\u7279\u963f\u62c9\u4f2f\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e7411\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u6b27\u76df\u52a0\u51b0\u5c9b\u3001\u5217\u652f\u6566\u58eb\u767b\u548c\u632a\u5a01\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u60a3\u8005\uff0c\u6216\u4f5c\u4e3a\u4e00\u7ebf\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u4e0d\u9002\u5408\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u7684\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e7412\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u82f1\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u7b26\u5408\u6761\u4ef6\u7684\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u6210\u4eba\u60a3\u8005\uff0c\u6216\u4f5c\u4e3a\u4e00\u7ebf\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u4e0d\u9002\u5408\u5316\u7597\u514d\u75ab\u6cbb\u7597\u7684\u7b26\u5408\u6761\u4ef6\u7684\u60a3\u8005\uff1b\u548c <\/li>\n<li>2021\u5e7412\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u5384\u74dc\u591a\u5c14\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\u3002<\/li>\n<\/ul>\n<p>\u8fc4\u4eca\u4e3a\u6b62\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5df2\u9012\u4ea4\u8d85\u8fc720\u9879\u9488\u5bf9\u591a\u9879\u9002\u5e94\u75c7\u7684\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n<p><sup>*<\/sup>\u8be5\u9879\u9002\u5e94\u75c7\u57fa\u4e8e\u603b\u7f13\u89e3\u7387\u83b7\u5f97\u52a0\u901f\u6279\u51c6\u3002\u9488\u5bf9\u8be5\u9002\u5e94\u75c7\u7684\u540e\u7eed\u6b63\u5f0f\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u786e\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u4e34\u5e8a\u76ca\u5904\u7684\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002<\/p>\n<p><sup>**<\/sup>\u8be5\u9879\u9002\u5e94\u75c7\u83b7\u9644\u6761\u4ef6\u6279\u51c6\u3002\u9488\u5bf9\u8be5\u9002\u5e94\u75c7\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u6b63\u5728\u5f00\u5c55\u7684\u786e\u8bc1\u6027\u968f\u673a\u3001\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3002<\/p>\n<p><b>\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66<\/b><\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u6216\u4e0e\u5fd7\u540c\u9053\u5408\u7684\u5408\u4f5c\u4f19\u4f34\u643a\u624b\uff0c\u4e0d\u65ad\u63a8\u52a8\u540c\u7c7b\u6700\u4f73\u6216\u540c\u7c7b<span id=\"spanHghlte8d4\">\u7b2c\u4e00<\/span>\u7684\u4e34\u5e8a\u5019\u9009\u836f\u7269\u7814\u53d1\uff0c\u81f4\u529b\u4e8e\u4e3a\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u6709\u6548\u3001\u53ef\u53ca\u4e14\u53ef\u8d1f\u62c5\u7684\u836f\u7269\u3002\u516c\u53f8\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u548c\u5f00\u53d1\u56e2\u961f\u5df2\u6709\u7ea62,900\u4eba\u4e14\u4ecd\u5728\u4e0d\u65ad\u58ee\u5927\uff0c\u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u56f4\u652f\u6301100\u591a\u9879\u6b63\u5728\u8fdb\u884c\u6216\u7b79\u5907\u4e2d\u7684\u4e34\u5e8a\u7814\u7a76\u7684\u5c55\u5f00\uff0c\u5df2\u62db\u52df\u60a3\u8005\u548c\u5065\u5eb7\u53d7\u8bd5\u8005\u8d85\u8fc714,500\u4eba\u3002\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u6df1\u539a\u3001\u8bd5\u9a8c\u5e03\u5c40\u5e7f\u6cdb\uff0c\u8bd5\u9a8c\u5df2\u8986\u76d6\u5168\u7403&nbsp;45 \u591a\u4e2a\u56fd\u5bb6\/\u5730\u533a\uff0c\u4e14\u5747\u7531\u516c\u53f8\u5185\u90e8\u56e2\u961f\u7275\u5934\u3002\u516c\u53f8\u6df1\u8015\u4e8e\u8840\u6db2\u80bf\u7624\u548c\u5b9e\u4f53\u80bf\u7624\u7684\u9776\u5411\u6cbb\u7597\u53ca\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u5f00\u53d1\uff0c\u540c\u65f6\u4e13\u6ce8\u4e8e\u5355\u836f\u7597\u6cd5\u548c\u8054\u5408\u7597\u6cd5\u7684\u63a2\u7d22\u3002\u76ee\u524d\uff0c\u767e\u6d4e\u795e\u5dde\u81ea\u4e3b\u7814\u53d1\u7684\u4e09\u6b3e\u836f\u7269\u5df2\u83b7\u6279\u4e0a\u5e02\uff1a\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\uff08BTK\u6291\u5236\u5242\uff0c\u5df2\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u6b27\u76df\u3001\u52a0\u62ff\u5927\u3001\u6fb3\u5927\u5229\u4e9a\u53ca\u5176\u4ed6\u56fd\u9645\u5e02\u573a\u83b7\u6279\u4e0a\u5e02\uff09\u3001\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\uff08\u53ef\u6709\u6548\u907f\u514dFc-\u03b3\u53d7\u4f53\u7ed3\u5408\u7684\u6297PD-1\u6297\u4f53\uff0c\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff09\u53ca\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\uff08\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff09\u3002<\/p>\n<p>\u540c\u65f6\uff0c\u767e\u6d4e\u795e\u5dde\u8fd8\u4e0e\u5176\u4ed6\u521b\u65b0\u516c\u53f8\u5408\u4f5c\uff0c\u5171\u540c\u643a\u624b\u63a8\u8fdb\u521b\u65b0\u7597\u6cd5\u7684\u7814\u53d1\uff0c\u4ee5\u6ee1\u8db3\u5168\u7403\u5065\u5eb7\u9700\u6c42\u3002\u5728\u4e2d\u56fd\uff0c\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u9500\u552e\u591a\u6b3e\u7531\u5b89\u8fdb\u548c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u6388\u6743\u7684\u80bf\u7624\u836f\u7269\u3002\u516c\u53f8\u4e5f\u901a\u8fc7\u4e0e\u5305\u62ec\u5b89\u8fdb\u3001\u767e\u5965\u6cf0\u3001EUSA Pharma\u3001Mirati Therapeutics\u3001Seagen \u4ee5\u53ca&nbsp;Zymeworks 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target=\"_blank\" href=\"http:\/\/www.beigene.com.cn\/\" rel=\"nofollow noopener\">www.beigene.com.cn<\/a>\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u6839\u636e\u300a1995\u5e74\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 1995\uff09\u4ee5\u53ca\u5176\u4ed6\u8054\u90a6\u8bc1\u5238\u6cd5\u5f8b\u4e2d\u5b9a\u4e49\u7684\u524d\u77bb\u6027\u58f0\u660e\uff0c\u5305\u62ec\u6709\u5173\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u7684\u6f5c\u5728\u4e34\u5e8a\u83b7\u76ca\u4e0e\u4f18\u52bf\uff0c\u767e\u6d4e\u795e\u5dde\u7684\u63a8\u8fdb\u8ba1\u5212\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u7684\u4e34\u5e8a\u5f00\u53d1\u3001\u836f\u653f\u91cc\u7a0b\u7891\u548c\u5546\u4e1a\u5316\u9884\u671f\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u7684\u6f5c\u5728\u5546\u4e1a\u5316\u673a\u4f1a\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u5bf9\u4e8e\u60a3\u8005\u53ef\u53ca\u6027\u7684\u8ba1\u5212\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u6210\u4e3a\u201c\u540c\u7c7b\u6700\u4f18\u201dBTK\u6291\u5236\u5242\u4ee5\u53ca\u6539\u5584\u60a3\u8005\u4e34\u5e8a\u83b7\u76ca\u7684\u6f5c\u529b\u7684\u58f0\u660e\uff0c\u4ee5\u53ca\u5728\u201c\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66\u201d\u548c\u201c\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u201d\u526f\u6807\u9898\u4e0b\u63d0\u53ca\u7684\u767e\u6d4e\u795e\u5dde\u8ba1\u5212\u3001\u627f\u8bfa\u3001\u62b1\u8d1f\u548c\u76ee\u6807\u3002\u7531\u4e8e\u5404\u79cd\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u58f0\u660e\u6709\u91cd\u5927\u5dee\u5f02\u3002\u8fd9\u4e9b\u56e0\u7d20\u5305\u62ec\u4e86\u4ee5\u4e0b\u4e8b\u9879\u7684\u98ce\u9669\uff1a\u767e\u6d4e\u795e\u5dde\u8bc1\u660e\u5176\u5019\u9009\u836f\u7269\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u80fd\u529b\uff1b\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u7ed3\u679c\u53ef\u80fd\u4e0d\u652f\u6301\u8fdb\u4e00\u6b65\u5f00\u53d1\u6216\u4e0a\u5e02\u5ba1\u6279\uff1b\u836f\u653f\u90e8\u95e8\u7684\u884c\u52a8\u53ef\u80fd\u4f1a\u5f71\u54cd\u5230\u4e34\u5e8a\u8bd5\u9a8c\u7684\u542f\u52a8\u3001\u65f6\u95f4\u8868\u548c\u8fdb\u5c55\u4ee5\u53ca\u836f\u7269\u4e0a\u5e02\u5ba1\u6279\uff1b\u767e\u6d4e\u795e\u5dde\u7684\u4e0a\u5e02\u836f\u7269\u53ca\u5019\u9009\u836f\u7269\uff08\u5982\u80fd\u83b7\u6279\uff09\u83b7\u5f97\u5546\u4e1a\u6210\u529f\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u83b7\u5f97\u548c\u7ef4\u62a4\u5bf9\u5176\u836f\u7269\u548c\u6280\u672f\u7684\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u4f9d\u8d56\u7b2c\u4e09\u65b9\u8fdb\u884c\u836f\u7269\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5176\u4ed6\u670d\u52a1\u7684\u60c5\u51b5\uff1b\u767e\u6d4e\u795e\u5dde\u53d6\u5f97\u76d1\u7ba1\u5ba1\u6279\u548c\u5546\u4e1a\u5316\u533b\u836f\u4ea7\u54c1\u7684\u6709\u9650\u7ecf\u9a8c\uff0c\u53ca\u5176\u83b7\u5f97\u8fdb\u4e00\u6b65\u7684\u8425\u8fd0\u8d44\u91d1\u4ee5\u5b8c\u6210\u5019\u9009\u836f\u7269\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u5e76\u4fdd\u6301\u76c8\u5229\u7684\u80fd\u529b\uff1b\u65b0\u51a0\u80ba\u708e\u5168\u7403\u5927\u6d41\u884c\u5bf9\u767e\u6d4e\u795e\u5dde\u7684\u4e34\u5e8a\u5f00\u53d1\u3001\u76d1\u7ba1\u3001\u5546\u4e1a\u5316\u8fd0\u8425\u4ee5\u53ca\u5176\u4ed6\u4e1a\u52a1\u5e26\u6765\u7684\u5f71\u54cd\uff1b\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5728\u6700\u8fd1\u5b63\u5ea6\u62a5\u544a\u768410-Q\u8868\u683c\u4e2d\u201c\u98ce\u9669\u56e0\u7d20\u201d\u7ae0\u8282\u91cc\u66f4\u5168\u9762\u8ba8\u8bba\u7684\u5404\u7c7b\u98ce\u9669\uff1b\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u671f\u540e\u5448\u62a5\u4e2d\u5173\u4e8e\u6f5c\u5728\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8ba8\u8bba\u3002\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u4ec5\u53ca\u4e8e\u65b0\u95fb\u7a3f\u53d1\u5e03\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6d4e\u795e\u5dde\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u8be5\u7b49\u4fe1\u606f\u3002<\/p>\n<p><sup><span id=\"spanHghlt13cb\">[1]<\/span><\/sup> American Cancer Society. Cancer Facts &amp; Figures 2021. <span class=\"xn-location\">Atlanta<\/span>; American Cancer Society; 2021. Available here: Cancer Facts and Figures 2021.<br \/><sup><span id=\"spanHghlt413f\">[2]<\/span><\/sup> Global Burden of Disease Cancer Collaboration. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017. JAMA Oncol. 2019;5(12):1749-1768.<br \/><sup><span id=\"spanHghlt924c\">[3]<\/span><\/sup> National Cancer Institute. Chronic Lymphocytic Leukemia Treatment (PDQ&reg;)\u2013Patient Version. Available here: Chronic Lymphocytic Leukemia Treatment (PDQ&reg;)\u2013Patient Version.<br \/><sup><span id=\"spanHghlte1df\">[4]<\/span><\/sup> Haselager MV et al. Proliferative Signals in Chronic Lymphocytic Leukemia; What Are We Missing? Front Oncol. 2020; 10: 592205.<br \/><sup><span id=\"spanHghltb5bf\">[5]<\/span><\/sup> Cancer Support Community. Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma. Available here: <a target=\"_blank\" href=\"https:\/\/www.cancersupportcommunity.org\/chronic-lymphocytic-leukemiasmall-lymphocytic-lymphoma\" rel=\"nofollow noopener\">https:\/\/www.cancersupportcommunity.org\/chronic-lymphocytic-leukemiasmall-lymphocytic-lymphoma<\/a>.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u6b64\u6b21\u7533\u8bf7\u4e2d\uff0c\u767e\u60a6\u6cfd\u00ae\u9996\u6b21\u5728\u4e2d\u56fd\u83b7\u5f97\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a \u6b64\u6b21\u7533\u8bf7\u662f\u57fa\u4e8eSEQUOIA\u8bd5\u9a8c\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u6570\u636e\u8bc1\u660e\u767e\u60a6\u6cfd\u00ae\u7684\u6709\u6548\u6027\u4f18\u4e8e\u5316\u5b66\u514d\u75ab\u6cbb\u7597 \u767e\u60a6\u6cfd\u00ae\u5df2\u4e8e2020\u5e746\u6708\u83b7\u5f97NMPA\u9644\u6761\u4ef6\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005 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