{"id":61128,"date":"2022-01-24T10:54:00","date_gmt":"2022-01-24T03:54:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022012410540061128"},"modified":"2022-01-24T18:00:56","modified_gmt":"2022-01-24T10:00:56","slug":"%e5%8d%a1%e5%ba%a6%e5%b0%bc%e5%88%a9%ef%bc%88pd-1-ctla-4%e5%8f%8c%e6%8a%97%ef%bc%89%e8%81%94%e5%90%88%e5%8c%96%e7%96%97%e4%b8%80%e7%ba%bf%e6%b2%bb%e7%96%97%e6%99%9a%e6%9c%9f%e8%83%83%e7%99%8c","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022012410540061128","title":{"rendered":"\u5361\u5ea6\u5c3c\u5229\uff08PD-1\/CTLA-4\u53cc\u6297\uff09\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u80c3\u764c\/\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\u7684Ib\/II\u671f\u7814\u7a76\u6210\u679c\u53d1\u5e03"},"content":{"rendered":"

\u9999\u6e2f2022\u5e741\u670824\u65e5 \/\u7f8e\u901a\u793e\/ — \u5eb7\u65b9\u751f\u7269\uff089926.HK\uff09\u5ba3\u5e03\u5361\u5ea6\u5c3c\u5229\uff08PD-1\/CTLA-4\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u7814\u53d1\u4ee3\u53f7\uff1aAK104\uff09\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u80c3\u764c\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c(G\/GEJ)\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff08\u6458\u8981 #308\uff09\u4eae\u76f82022\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u80c3\u80a0\u9053\u80bf\u7624\u7814\u8ba8\u4f1a(ASCO GI)\u3002\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u9662\u957f\u5b63\u52a0\u5b5a\u6559\u6388\u5728\u4f1a\u8bae\u4e2d\u53e3\u5934\u62a5\u544a\u4e86\u8be5\u9879\u7814\u7a76\u7ed3\u679c\u3002<\/p>\n

\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0cPD-L1 CPS>=<\/span>5\u7684\u4eba\u7fa4\u5360\u6bd4\u4ec5\u4e3a15%\u80cc\u666f\u4e0b\uff0c\u5168\u4eba\u7fa4\u7684mPFS \u8fbe9.2<\/span> \u4e2a\u6708\uff0cmOS \u8fbe17.08 \u4e2a\u6708\uff0c\u663e\u8457\u9ad8\u4e8e\u5316\u7597\uff0810-12\u4e2a\u6708\uff09\u548cPD-1\u7597\u6cd5\uff08Checkmate 649 13.8\u4e2a\u6708\uff09\u3002<\/p>\n

ASCO GI\u662f\u5168\u7403\u9876\u7ea7\u7684\u6d88\u5316\u7cfb\u7edf\u80bf\u7624\u5b66\u672f\u4f1a\u8bae\uff0c\u672c\u5c4a\u4f1a\u8bae\u56f4\u7ed5\u201c\u6700\u5177\u521b\u65b0\u6027\u7684\u79d1\u5b66\u8fdb\u5c55\u201d\u4e3b\u9898\u5c55\u5f00\u7814\u8ba8\uff0c\u80c3\u764c\u514d\u75ab\u6cbb\u7597\u8fdb\u5c55\u6210\u4e3a\u5907\u53d7\u5173\u6ce8\u7684\u8bdd\u9898\u3002<\/p>\n

\u80c3\u764c\u53d1\u75c5\u7387\u5168\u7403\u4f4d\u5c45\u7b2c\u4e94\uff0c\u4e5f\u662f\u5168\u7403\u7b2c\u56db\u5927\u764c\u75c7\u6b7b\u4ea1\u539f\u56e0[1]<\/span><\/sup>\u3002\u76ee\u524d\u5df2\u6709\u4e24\u9879III\u671f\u7814\u7a76\u7ed3\u679c\u8bc1\u660e\u4e86\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8054\u5408\u5316\u7597\u5728G\/GEJ\u817a\u764c\u6cbb\u7597\u4e2d\u7684\u534f\u540c\u4f5c\u7528[2]-[3]<\/span><\/sup>\u3002\u4e0e PD-1\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c\u6297PD-1\u548c\u6297CTLA-4\u836f\u7269\u7684\u8054\u5408\u6cbb\u7597\u62e5\u6709\u66f4\u9ad8\u53cd\u5e94\u7387\uff0c\u4f46\u6bd2\u526f\u4f5c\u7528\u4e5f\u66f4\u9ad8\u3002<\/p>\n

2021\u5e74ESMO\u4f1a\u8bae\u516c\u5e03\u7684\u4e00\u9879PD-1\u5355\u6297\u8054\u5408CTLA-4\u5355\u6297\u6cbb\u7597\u80c3\u764c\u4e0e\u98df\u7ba1\u764c\u7684\u7814\u7a76\u663e\u793aORR\u83b7\u5f97\u4e86\u663e\u8457\u7684\u63d0\u9ad8\uff0c\u4f46\u56e0\u4e3a\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u95ee\u9898\uff0c\u8be5\u9879\u7814\u7a76\u672a\u80fd\u8fbe\u5230\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\uff0c\u5ba3\u544a\u5931\u8d25\u3002\u5982\u4f55\u80fd\u591f\u7ef4\u6301CTLA-4\u5355\u6297\u7597\u6548\u5e76\u964d\u4f4e\u6bd2\u526f\u4f5c\u7528\uff0c\u5b9e\u73b0\u957f\u671f\u751f\u5b58\u83b7\u76ca\uff0c\u6210\u4e3a\u4e86\u4e34\u5e8a\u5b9e\u8df5\u7684\u91cd\u8981\u76ee\u6807\u3002<\/p>\n

2021\u5e74\uff0c\u7814\u7a76\u4eba\u5458\u901a\u8fc7AK104\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u80c3\u764c\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c(G\/GEJ)\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u4ece\u7528\u836f\u5242\u91cf\u3001\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u65b9\u9762\u8fdb\u884c\u4e86\u63a2\u7d22\uff0c\u8bc1\u660e\u4e86AK104\u8054\u5408\u5316\u7597\u6cbb\u7597G\/GEJ\u817a\u764c\u7684\u51fa\u8272\u4e34\u5e8a\u8868\u73b0\u3002<\/p>\n

\u5728\u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u5165\u7ec4\u60a3\u8005\u4e3a\u665a\u671f\u80c3\u764c\u4e00\u7ebf\u672a\u7ecf\u6cbb\u7597\u4e14\u4e0d\u8003\u8651PD-L1\u8868\u8fbe\u6c34\u5e73\u3002\u5728 Ib \u7684\u5242\u91cf\u722c\u5761\u548c\u5242\u91cf\u62d3\u5c55\u9636\u6bb5\uff0c\u60a3\u8005\u5206\u522b\u63a5\u53d7\u4e86 AK104\uff084 mg\/kg\u30016 mg\/kg\u300110 mg\/kg Q2W \u6216 15mg\/kg Q3W\uff09\u4e0eXELOX \u7684\u8054\u5408\u6cbb\u7597\uff1b\u5728II\u7684\u5242\u91cf\u786e\u8ba4\u9636\u6bb5\uff0c\u60a3\u8005\u63a5\u53d7\u4e86 AK104\uff086 mg\/kg Q2W \u6216 10mg\/kg Q3W\uff09\u4e0eXELOX \u8054\u5408\u6cbb\u7597\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n

\u7ed3\u5408\u5b63\u6559\u6388\u7684\u62a5\u544a\u548c\u622a\u81f32021\/12\/31\u7684\u6700\u65b0\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u7814\u7a76\u5171\u5165\u7ec498 \u540d\u60a3\u8005\uff0cPD-L1 CPS>=<\/span>5\u7684\u4eba\u7fa4\u5360\u6bd4\u4ec5\u4e3a15%\uff0c\u8be5\u4eba\u7fa4\u6bd4\u4f8b\u8fdc\u4f4e\u4e8eCheckmate 649\u548cOrient-16\uff08\u5747\u8d85\u8fc760%\uff09\u3002<\/p>\n

AK104\u9488\u5bf9\u5168\u4eba\u7fa4\u663e\u793a\u51fa\u957f\u671f\u751f\u5b58\u83b7\u76ca\u7684\u4f18\u52bf\u3002\u622a\u81f32021\/12\/31\u7684\u6700\u65b0\u7814\u7a76\u7ed3\u679c\uff0c91\u540d\u60a3\u8005\u8fdb\u884c\u4e86\u81f3\u5c11\u4e00\u6b21\u7684\u57fa\u7ebf\u540e\u80bf\u7624\u8bc4\u4f30\u3002ORR\u8fbe\u523068.1%\uff0c\u5176\u4e2d62\u8fbe\u5230PR\uff0cDCR\u9ad8\u8fbe92.3%\u3002\u800c\u9ad8\u5242\u91cf\u7ec410mg\/kg Q2W\u4e2d\u7684ORR\u9ad8\u8fbe83.3%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u9ad8\u8fbe100%\u3002\u5168\u4eba\u7fa4\u7684\u4e2d\u4f4d PFS \u4e3a 9.2<\/span> \u4e2a\u6708\uff0c\u4e2d\u4f4dOS \u4e3a 17.08 \u4e2a\u6708\uff0c\u663e\u8457\u9ad8\u4e8e\u5316\u7597\uff0810-12\u4e2a\u6708\uff09\u548cPD-1\u7597\u6cd5\uff08Checkmate 649 13.8\u4e2a\u6708\uff09\u3002<\/p>\n

AK104\u5728PD-L1\u4f4e\u8868\u8fbe\u60a3\u8005\u4e2d\u4ecd\u7ef4\u6301\u663e\u8457\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u3002PD-L1 CPS>=<\/span>1 \u548cCPS\uff1c1\u7684\u60a3\u8005\u4e2d\uff0c\u4e2d\u4f4dOS\u5206\u522b\u4e3a17.41\u4e2a\u6708\u300114.65\u4e2a\u6708\u3002\u57284mg\/kg\u548c6mg\/kg\u5242\u91cf\u7ec4\u7684\u6210\u719f\u6570\u636e\u4e2d\uff0c\u5bf9\u4e8ePD-L1 CPS<5\u7684\u4eba\u7fa4\u4e5f\u6709\u663e\u8457\u4f18\u52bf\uff0cmOS\u8fbe\u523017.2\u4e2a\u6708\uff0c\u5bf9\u5168\u4eba\u7fa4\u7684\u8d21\u732e\u4f18\u4e8ePD-1\u7597\u6cd5\u3002<\/p>\n

\u76f8\u5bf9\u4e8ePD-1\u5355\u6297\uff0cAK104\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\uff0c\u5b89\u5168\u6027\u826f\u597d\u3002>=<\/span>3\u7ea7\u836f\u7269\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff08TRAEs\uff09\u53d1\u751f\u7387\u4e3a62.5%\uff1b\u836f\u7269\u76f8\u5173\u6027\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff08TRSAEs\uff09\u53d1\u751f\u7387\u4e3a41.7%\uff1b>=<\/span>3\u7ea7\u8f93\u6ce8\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u4ec5\u4e3a3.1%\u3002\u968f\u7740\u5242\u91cf\u7684\u589e\u52a0\uff0c\u4e0d\u826f\u4e8b\u4ef6\u6ca1\u6709\u663e\u8457\u589e\u52a0\u3002\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u4fe1\u53f7\u3002<\/p>\n

\u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u662f\u5168\u7403\u9996\u4e2aPD-1\/CTLA-4\u53cc\u7279\u5f02\u6027\u6297\u4f53\u8054\u5408\u5316\u7597\u7528\u4e8e\u8f6c\u79fb\u6027\u80c3\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u5728\u4e00\u7ebf\u5168\u4eba\u7fa4\u9002\u7528\u3001\u751f\u5b58\u83b7\u76ca\u63d0\u9ad8\u65b9\u9762\u7684\u63a2\u7d22\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u57fa\u4e8eIb\/II\u671f\u51fa\u8272\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7ed3\u679c\u7684\u5faa\u8bc1\u652f\u6491\uff0cAK104\u6709\u671b\u8d85\u8d8a\u5f53\u524d\u514d\u75ab\u7597\u6cd5\uff0c\u4e3a\u66f4\u591a\u60a3\u8005\u5e26\u6765\u65b0\u7684\u4e00\u7ebf\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n

\u76ee\u524dAK104\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u80c3\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\u7684III\u671f\u5173\u952e\u6027\u6ce8\u518c\u6027\u8bd5\u9a8c\uff08NCT05008783\uff09\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u5e76\u5728\u5168\u7403\u8303\u56f4\u5185\u5f00\u5c55\u4e86\u591a\u9879\u5728\u91cd\u78c5\u5b9e\u4f53\u7624\u4e2d\u7684\u8054\u5408\u6cbb\u7597\u7814\u7a76\u3002\u516c\u53f8\u6b63\u5728\u5168\u529b\u63a8\u8fdb\u201c\u4ee5\u53cc\u7279\u5f02\u6027\u6297\u4f53\u4e3a\u57fa\u77f3\u7684\u65b0\u4e00\u4ee3\u514d\u75ab\u7597\u6cd5\u201d\uff0c\u4ee5\u60e0\u53ca\u66f4\u591a\u60a3\u8005\u3002<\/p>\n

\n\n\n\n\n\n\n
\n

\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[1]. Sung H et al. Global Cancer Statistics 2020. GLOBOCAN.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[2].Yelena YJ et al. Lancet 2021; 398: 27-40. <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[3]. Jianming Xu et al. Annals of Oncology (2021) 32 (suppl_5): S1331. <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u9999\u6e2f2022\u5e741\u670824\u65e5 \/\u7f8e\u901a\u793e\/ — \u5eb7\u65b9\u751f\u7269\uff089926.HK\uff09\u5ba3\u5e03\u5361\u5ea6\u5c3c\u5229\uff08PD-1\/CTLA-4\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u7814\u53d1\u4ee3\u53f7\uff1aAK104\uff09\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u80c3\u764c\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c(G\/GEJ)\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff08\u6458\u8981 #308\uff09\u4eae\u76f82022\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u80c3\u80a0\u9053\u80bf\u7624\u7814\u8ba8\u4f1a(ASCO GI)\u3002\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u9662\u957f\u5b63\u52a0\u5b5a\u6559\u6388\u5728\u4f1a\u8bae\u4e2d\u53e3\u5934\u62a5\u544a\u4e86\u8be5\u9879\u7814\u7a76\u7ed3\u679c\u3002 \u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0cPD-L1 CPS>=5\u7684\u4eba\u7fa4\u5360\u6bd4\u4ec5\u4e3a15%\u80cc\u666f\u4e0b\uff0c\u5168\u4eba\u7fa4\u7684mPFS \u8fbe9.2 \u4e2a\u6708\uff0cmOS \u8fbe17.08 \u4e2a\u6708\uff0c\u663e\u8457\u9ad8\u4e8e\u5316\u7597\uff0810-12\u4e2a\u6708\uff09\u548cPD-1\u7597\u6cd5\uff08Checkmate 649 13.8\u4e2a\u6708\uff09\u3002 ASCO GI\u662f\u5168\u7403\u9876\u7ea7\u7684\u6d88\u5316\u7cfb\u7edf\u80bf\u7624\u5b66\u672f\u4f1a\u8bae\uff0c\u672c\u5c4a\u4f1a\u8bae\u56f4\u7ed5\u201c\u6700\u5177\u521b\u65b0\u6027\u7684\u79d1\u5b66\u8fdb\u5c55\u201d\u4e3b\u9898\u5c55\u5f00\u7814\u8ba8\uff0c\u80c3\u764c\u514d\u75ab\u6cbb\u7597\u8fdb\u5c55\u6210\u4e3a\u5907\u53d7\u5173\u6ce8\u7684\u8bdd\u9898\u3002 \u80c3\u764c\u53d1\u75c5\u7387\u5168\u7403\u4f4d\u5c45\u7b2c\u4e94\uff0c\u4e5f\u662f\u5168\u7403\u7b2c\u56db\u5927\u764c\u75c7\u6b7b\u4ea1\u539f\u56e0[1]\u3002\u76ee\u524d\u5df2\u6709\u4e24\u9879III\u671f\u7814\u7a76\u7ed3\u679c\u8bc1\u660e\u4e86\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8054\u5408\u5316\u7597\u5728G\/GEJ\u817a\u764c\u6cbb\u7597\u4e2d\u7684\u534f\u540c\u4f5c\u7528[2]-[3]\u3002\u4e0e PD-1\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c\u6297PD-1\u548c\u6297CTLA-4\u836f\u7269\u7684\u8054\u5408\u6cbb\u7597\u62e5\u6709\u66f4\u9ad8\u53cd\u5e94\u7387\uff0c\u4f46\u6bd2\u526f\u4f5c\u7528\u4e5f\u66f4\u9ad8\u3002 2021\u5e74ESMO\u4f1a\u8bae\u516c\u5e03\u7684\u4e00\u9879PD-1\u5355\u6297\u8054\u5408CTLA-4\u5355\u6297\u6cbb\u7597\u80c3\u764c\u4e0e\u98df\u7ba1\u764c\u7684\u7814\u7a76\u663e\u793aORR\u83b7\u5f97\u4e86\u663e\u8457\u7684\u63d0\u9ad8\uff0c\u4f46\u56e0\u4e3a\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u95ee\u9898\uff0c\u8be5\u9879\u7814\u7a76\u672a\u80fd\u8fbe\u5230\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\uff0c\u5ba3\u544a\u5931\u8d25\u3002\u5982\u4f55\u80fd\u591f\u7ef4\u6301CTLA-4\u5355\u6297\u7597\u6548\u5e76\u964d\u4f4e\u6bd2\u526f\u4f5c\u7528\uff0c\u5b9e\u73b0\u957f\u671f\u751f\u5b58\u83b7\u76ca\uff0c\u6210\u4e3a\u4e86\u4e34\u5e8a\u5b9e\u8df5\u7684\u91cd\u8981\u76ee\u6807\u3002 2021\u5e74\uff0c\u7814\u7a76\u4eba\u5458\u901a\u8fc7AK104\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u80c3\u764c\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c(G\/GEJ)\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u4ece\u7528\u836f\u5242\u91cf\u3001\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u65b9\u9762\u8fdb\u884c\u4e86\u63a2\u7d22\uff0c\u8bc1\u660e\u4e86AK104\u8054\u5408\u5316\u7597\u6cbb\u7597G\/GEJ\u817a\u764c\u7684\u51fa\u8272\u4e34\u5e8a\u8868\u73b0\u3002 \u5728\u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u5165\u7ec4\u60a3\u8005\u4e3a\u665a\u671f\u80c3\u764c\u4e00\u7ebf\u672a\u7ecf\u6cbb\u7597\u4e14\u4e0d\u8003\u8651PD-L1\u8868\u8fbe\u6c34\u5e73\u3002\u5728 Ib \u7684\u5242\u91cf\u722c\u5761\u548c\u5242\u91cf\u62d3\u5c55\u9636\u6bb5\uff0c\u60a3\u8005\u5206\u522b\u63a5\u53d7\u4e86 AK104\uff084 mg\/kg\u30016 mg\/kg\u300110 mg\/kg Q2W \u6216 15mg\/kg Q3W\uff09\u4e0eXELOX \u7684\u8054\u5408\u6cbb\u7597\uff1b\u5728II\u7684\u5242\u91cf\u786e\u8ba4\u9636\u6bb5\uff0c\u60a3\u8005\u63a5\u53d7\u4e86 AK104\uff086 mg\/kg Q2W \u6216 10mg\/kg Q3W\uff09\u4e0eXELOX \u8054\u5408\u6cbb\u7597\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002 \u7ed3\u5408\u5b63\u6559\u6388\u7684\u62a5\u544a\u548c\u622a\u81f32021\/12\/31\u7684\u6700\u65b0\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u7814\u7a76\u5171\u5165\u7ec498 \u540d\u60a3\u8005\uff0cPD-L1 CPS>=5\u7684\u4eba\u7fa4\u5360\u6bd4\u4ec5\u4e3a15%\uff0c\u8be5\u4eba\u7fa4\u6bd4\u4f8b\u8fdc\u4f4e\u4e8eCheckmate 649\u548cOrient-16\uff08\u5747\u8d85\u8fc760%\uff09\u3002 AK104\u9488\u5bf9\u5168\u4eba\u7fa4\u663e\u793a\u51fa\u957f\u671f\u751f\u5b58\u83b7\u76ca\u7684\u4f18\u52bf\u3002\u622a\u81f32021\/12\/31\u7684\u6700\u65b0\u7814\u7a76\u7ed3\u679c\uff0c91\u540d\u60a3\u8005\u8fdb\u884c\u4e86\u81f3\u5c11\u4e00\u6b21\u7684\u57fa\u7ebf\u540e\u80bf\u7624\u8bc4\u4f30\u3002ORR\u8fbe\u523068.1%\uff0c\u5176\u4e2d62\u8fbe\u5230PR\uff0cDCR\u9ad8\u8fbe92.3%\u3002\u800c\u9ad8\u5242\u91cf\u7ec410mg\/kg Q2W\u4e2d\u7684ORR\u9ad8\u8fbe83.3%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u9ad8\u8fbe100%\u3002\u5168\u4eba\u7fa4\u7684\u4e2d\u4f4d PFS \u4e3a 9.2 \u4e2a\u6708\uff0c\u4e2d\u4f4dOS \u4e3a 17.08 \u4e2a\u6708\uff0c\u663e\u8457\u9ad8\u4e8e\u5316\u7597\uff0810-12\u4e2a\u6708\uff09\u548cPD-1\u7597\u6cd5\uff08Checkmate 649 13.8\u4e2a\u6708\uff09\u3002 AK104\u5728PD-L1\u4f4e\u8868\u8fbe\u60a3\u8005\u4e2d\u4ecd\u7ef4\u6301\u663e\u8457\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u3002PD-L1 CPS>=1 \u548cCPS\uff1c1\u7684\u60a3\u8005\u4e2d\uff0c\u4e2d\u4f4dOS\u5206\u522b\u4e3a17.41\u4e2a\u6708\u300114.65\u4e2a\u6708\u3002\u57284mg\/kg\u548c6mg\/kg\u5242\u91cf\u7ec4\u7684\u6210\u719f\u6570\u636e\u4e2d\uff0c\u5bf9\u4e8ePD-L1 CPS<5\u7684\u4eba\u7fa4\u4e5f\u6709\u663e\u8457\u4f18\u52bf\uff0cmOS\u8fbe\u523017.2\u4e2a\u6708\uff0c\u5bf9\u5168\u4eba\u7fa4\u7684\u8d21\u732e\u4f18\u4e8ePD-1\u7597\u6cd5\u3002 \u76f8\u5bf9\u4e8ePD-1\u5355\u6297\uff0cAK104\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\uff0c\u5b89\u5168\u6027\u826f\u597d\u3002>=3\u7ea7\u836f\u7269\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff08TRAEs\uff09\u53d1\u751f\u7387\u4e3a62.5%\uff1b\u836f\u7269\u76f8\u5173\u6027\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff08TRSAEs\uff09\u53d1\u751f\u7387\u4e3a41.7%\uff1b>=3\u7ea7\u8f93\u6ce8\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u4ec5\u4e3a3.1%\u3002\u968f\u7740\u5242\u91cf\u7684\u589e\u52a0\uff0c\u4e0d\u826f\u4e8b\u4ef6\u6ca1\u6709\u663e\u8457\u589e\u52a0\u3002\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u4fe1\u53f7\u3002 \u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u662f\u5168\u7403\u9996\u4e2aPD-1\/CTLA-4\u53cc\u7279\u5f02\u6027\u6297\u4f53\u8054\u5408\u5316\u7597\u7528\u4e8e\u8f6c\u79fb\u6027\u80c3\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u5728\u4e00\u7ebf\u5168\u4eba\u7fa4\u9002\u7528\u3001\u751f\u5b58\u83b7\u76ca\u63d0\u9ad8\u65b9\u9762\u7684\u63a2\u7d22\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u57fa\u4e8eIb\/II\u671f\u51fa\u8272\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7ed3\u679c\u7684\u5faa\u8bc1\u652f\u6491\uff0cAK104\u6709\u671b\u8d85\u8d8a\u5f53\u524d\u514d\u75ab\u7597\u6cd5\uff0c\u4e3a\u66f4\u591a\u60a3\u8005\u5e26\u6765\u65b0\u7684\u4e00\u7ebf\u6cbb\u7597\u9009\u62e9\u3002 \u76ee\u524dAK104\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u80c3\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\u7684III\u671f\u5173\u952e\u6027\u6ce8\u518c\u6027\u8bd5\u9a8c\uff08NCT05008783\uff09\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u5e76\u5728\u5168\u7403\u8303\u56f4\u5185\u5f00\u5c55\u4e86\u591a\u9879\u5728\u91cd\u78c5\u5b9e\u4f53\u7624\u4e2d\u7684\u8054\u5408\u6cbb\u7597\u7814\u7a76\u3002\u516c\u53f8\u6b63\u5728\u5168\u529b\u63a8\u8fdb\u201c\u4ee5\u53cc\u7279\u5f02\u6027\u6297\u4f53\u4e3a\u57fa\u77f3\u7684\u65b0\u4e00\u4ee3\u514d\u75ab\u7597\u6cd5\u201d\uff0c\u4ee5\u60e0\u53ca\u66f4\u591a\u60a3\u8005\u3002 \u53c2\u8003\u6587\u732e\uff1a [1]. Sung H… Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-61128","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/61128","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=61128"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/61128\/revisions"}],"predecessor-version":[{"id":61129,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/61128\/revisions\/61129"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=61128"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=61128"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=61128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}