{"id":60944,"date":"2022-01-22T07:00:00","date_gmt":"2022-01-22T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022012207000060944"},"modified":"2022-01-22T17:54:42","modified_gmt":"2022-01-22T09:54:42","slug":"%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%92%8c%e7%a4%bc%e6%9d%a5%e5%88%b6%e8%8d%af%e5%9c%a82022%e5%b9%b4asco-gi%e5%85%b1%e5%90%8c%e5%85%ac%e5%b8%83%e8%be%be%e4%bc%af%e8%88%92%ef%bc%88%e4%bf%a1%e8%bf%aa","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022012207000060944","title":{"rendered":"\u4fe1\u8fbe\u751f\u7269\u548c\u793c\u6765\u5236\u836f\u57282022\u5e74ASCO 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(26%)\u3002\u4f4e\u5242\u91cf\u7ec4\u548c\u9ad8\u5242\u91cf\u7ec4\u22653\u7ea7\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u5206\u522b\u4e3a13.8%\u548c28.6%\u3002<\/p>\n<p>\u6709\u6548\u6027\u65b9\u9762\uff0c\u603b\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a34%\uff0817\/50\uff09\uff0c\u5176\u4e2d\u4f4e\u5242\u91cf\u7ec4\u548c\u9ad8\u5242\u91cf\u7ec4\u7684ORR\u5206\u522b\u4e3a31%\u548c38%\u3002\u603b\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u4e3a78% (39\/50)\u3002\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff0910.5\u4e2a\u6708 (95%CI, 8.4-12.7)\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u65f6\u95f4\uff08OS\uff0920.2\u4e2a\u6708 (95%CI, 16.1-24.3)\u3002\u8fdb\u4e00\u6b65\u7684\u751f\u7269\u6807\u5fd7\u7269\u5206\u6790\u8868\u660e\uff0c CD137\u8840\u6e05\u6d53\u5ea6\u226531.8 pg\/mL\u7684\u53d7\u8bd5\u8005\u6709\u66f4\u957f\u7684PFS (mPFS: 14.2 vs. 4.1\u4e2a\u6708, p=0.001)\u548cOS (mOS: \u672a\u8fbe\u5230vs.15.6\u4e2a\u6708, p=0.023)\u3002\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u5206\u6790\uff08TiME\uff09\u663e\u793a\u95f4\u8d28M1\u5de8\u566c\u7ec6\u80de (CD68+, CD163-)\u7684\u9ad8\u5bc6\u5ea6\u4e0e\u66f4\u4f73\u7684\u7597\u6548\uff0c\u66f4\u957f\u7684PFS\u548cOS\u663e\u8457\u76f8\u5173\u3002<\/p>\n<p><b>\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662\u5468\u7231\u840d\u6559\u6388\u8868\u793a<\/b>\uff1a\u201c\u672c\u7814\u7a76\u4e0d\u4ec5\u4e3a\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u4e0d\u540c\u5242\u91cf\u7684\u8d1d\u4f10\u73e0\u5355\u6297\u63d0\u4f9b\u4e86\u5b89\u5168\u6027\u548c\u7597\u6548\u6570\u636e\uff0c\u5e76\u4e14\u53d1\u73b0\u4e86\u53ef\u9884\u6d4b\u8054\u5408\u65b9\u6848\u6cbb\u7597\u809d\u7ec6\u80de\u764c\u7597\u6548\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5bf9\u4e8e\u4e34\u5e8a\u6307\u5bfc\u7528\u836f\u4e2d\u7cbe\u51c6\u6cbb\u7597\u4eba\u7fa4\u7684\u9009\u62e9\u63d0\u4f9b\u4e00\u5b9a\u7684\u4f9d\u636e\u3002<span id=\"spanHghlt0d57\">\u201d<\/span><\/p>\n<p><b>\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\u9ad8\u7ea7\u526f\u603b\u88c1\u5468\u8f89\u535a\u58eb\u8868\u793a<\/b>\uff1a\u201c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u5df2\u7ecf\u4e8e\u53bb\u5e746\u6708\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u5e76\u6210\u529f\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u3002\u672c\u7814\u7a76\u63d0\u4f9b\u4e86\u4e24\u79cd\u4e0d\u540c\u5242\u91cf\u8d1d\u4f10\u73e0\u5355\u6297\u4e0e\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u4f7f\u7528\u7684\u6570\u636e\uff0c\u540c\u65f6\uff0c\u63a2\u7d22\u4e86\u809d\u764c\u514d\u75ab\u6cbb\u7597\u7597\u6548\u7684\u9884\u6d4b\u6307\u6807\uff0c\u7ed9\u4e34\u5e8a\u533b\u751f\u63d0\u4f9b\u4e86\u66f4\u591a\u3001\u66f4\u597d\u7684\u9009\u62e9\uff0c\u63a8\u52a8\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u8fdb\u4e00\u6b65\u5411\u7cbe\u51c6\u5316\u3001\u4e2a\u4f53\u5316\u8fc8\u8fdb\u3002<span id=\"spanHghlt0d57\">\u201d<\/span><\/p>\n<p><b>\u793c\u6765\u4e2d\u56fd\u9ad8\u7ea7\u526f\u603b\u88c1\uff0c\u836f\u7269\u53d1\u5c55\u53ca\u533b\u5b66\u4e8b\u52a1\u4e2d\u5fc3\u8d1f\u8d23\u4eba\u738b\u8389\u535a\u58eb\u8868\u793a<\/b>\uff1a\u201c\u793c\u6765\u548c\u4fe1\u8fbe\u751f\u7269\u53cc\u65b9\u5408\u4f5c\u81f4\u529b\u4e3a\u4e2d\u56fd\u80bf\u7624\u60a3\u8005\u5e26\u6765\u5177\u6709\u56fd\u9645\u54c1\u8d28\u7684\u6297\u80bf\u7624\u836f\u7269\u3002\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764cIb\u671f\u7814\u7a76\u6570\u636e\u7684\u53d1\u5e03\u4e3a\u4e34\u5e8a\u6cbb\u7597\u63d0\u4f9b\u66f4\u592f\u5b9e\u7684\u4e2a\u4f53\u5316\u7cbe\u51c6\u6cbb\u7597\u7684\u4f9d\u636e\uff0c\u4e3a\u5b9e\u73b02030\u5e74\u603b\u4f53\u764c\u75c75\u5e74\u751f\u5b58\u7387\u63d0\u9ad815%\u7684\u76ee\u6807\uff0c\u52a9\u529b\u2018\u5065\u5eb7\u4e2d\u56fd2030\u2018\u884c\u52a8\u7684\u52a0\u5feb\u5b9e\u65bd\u63d0\u4f9b\u6709\u529b\u652f\u6301\u3002\u6211\u4eec\u671f\u5f85\u672a\u6765\u548c\u4fe1\u8fbe\u751f\u7269\u7ee7\u7eed\u6df1\u5165\u5408\u4f5c\uff0c\u4e3a\u66f4\u591a\u60a3\u8005\u5e26\u6765\u798f\u97f3\u3002\u201d<\/p>\n<p><b>\u5173\u4e8e<\/b><b>NCT04072679 \u7814\u7a76<\/b><\/p>\n<p>NCT04072679 \u662f\u8bc4\u4f30\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u5728\u665a\u671f\u809d\u7ec6\u80de\u764c\u53d7\u8bd5\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u6297\u80bf\u7624\u6d3b\u6027\u7684Ib\u671f\u7814\u7a76\u3002\u7814\u7a76\u5206\u4e3a\u4e24\u4e2a\u90e8\u5206\uff0c\u7b2c\u4e00\u90e8\u5206\u4e3a\u5242\u91cf\u9012\u589e\u7814\u7a76\uff0c\u7b2c\u4e8c\u90e8\u5206\u4e3a\u5242\u91cf\u6269\u5c55\u7814\u7a76\u3002\u5728\u5242\u91cf\u9012\u589e\u9636\u6bb5\uff0c\u53d7\u8bd5\u8005\u5c06\u6839\u636e\u5165\u7ec4\u987a\u5e8f\u5206\u522b\u63a5\u53d77.5mg\/kg\uff08\u4f4e\u5242\u91cf\u7ec4\uff09\u621615 mg\/kg\uff08\u9ad8\u5242\u91cf\u7ec4\uff09\u7684\u8d1d\u4f10\u73e0\u5355\u6297\uff0c\u540c\u65f6\u8054\u5408\u56fa\u5b9a\u5242\u91cf\u7684\u8fbe\u4f2f\u8212&reg;200mg\u6cbb\u7597\uff0c\u5b8c\u6210\u5242\u91cf\u9012\u589e\u7814\u7a76\u540e\uff0c\u8fdb\u5165\u5242\u91cf\u6269\u5c55\u9636\u6bb5\u3002<\/p>\n<p><b>\u5173\u4e8e\u809d\u764c<\/b><\/p>\n<p>\u809d\u764c\u662f\u5168\u4e16\u754c\u8303\u56f4\u5185\u5e38\u89c1\u7684\u6d88\u5316\u7cfb\u7edf\u6076\u6027\u80bf\u7624\uff0c\u4e2d\u56fd\u7684\u809d\u764c\u60a3\u8005\u5360\u5168\u7403\u6570\u91cf\u7684\u4e00\u534a\u5de6\u53f3\uff0c\u809d\u764c\u4e25\u91cd\u5730\u5a01\u80c1\u6211\u56fd\u4eba\u6c11\u7684\u751f\u547d\u548c\u5065\u5eb7\u3002\u809d\u764c\u7684\u75c5\u7406\u7c7b\u578b\u4e3b\u8981\u662f\u809d\u7ec6\u80de\u764c\uff08hepatocellular carcinoma\uff0cHCC\uff09\uff0c\u536085%~90%\uff1b\u8fd8\u6709\u5c11\u6570\u4e3a\u809d\u5185\u80c6\u7ba1\u764c\uff08intrahepatic cholangiocarcinoma\uff0cICC\uff09\u548cHCC-ICC \u6df7\u5408\u578b\u7b49\u3002\u5728\u6211\u56fd\uff0cHCC\u4e3b\u8981\u7531\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08hepatitis B virus\uff0cHBV\uff09\u548c\/\u6216\u4e19\u578b\u809d\u708e\u75c5\u6bd2\uff08hepatitis C virus\uff0cHCV\uff09\u611f\u67d3\u5f15\u8d77\u3002<\/p>\n<p><b>\u5173\u4e8e\u4fe1\u8fea\u5229\u5355\u6297<\/b><\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\uff0c\u4e2d\u56fd\u5546\u54c1\u540d\u4e3a\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u548c\u793c\u6765\u5236\u836f\u5171\u540c\u5408\u4f5c\u7814\u53d1\u7684\u5177\u6709\u56fd\u9645\u54c1\u8d28\u7684\u521b\u65b0PD-1\u6291\u5236\u5242\u836f\u7269\u3002\u4fe1\u8fea\u5229\u5355\u6297\u662f\u4e00\u79cd\u4eba\u7c7b\u514d\u75ab\u7403\u86cb\u767dG4\uff08IgG4\uff09\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u7279\u5f02\u6027\u7ed3\u5408T\u7ec6\u80de\u8868\u9762\u7684PD-1\u5206\u5b50\uff0c\u4ece\u800c\u963b\u65ad\u5bfc\u81f4\u80bf\u7624\u514d\u75ab\u8010\u53d7\u7684 PD-1\/\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53\u914d\u4f531\uff08Programmed Death-Ligand 1, PD-L1\uff09\u901a\u8def\uff0c\u91cd\u65b0\u6fc0\u6d3b\u6dcb\u5df4\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684\u3002\u76ee\u524d\u6709\u8d85\u8fc7\u4e8c\u5341\u591a\u4e2a\u4e34\u5e8a\u7814\u7a76\uff08\u5176\u4e2d10\u591a\u9879\u662f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\uff09\u6b63\u5728\u8fdb\u884c\uff0c\u4ee5\u8bc4\u4f30\u4fe1\u8fea\u5229\u5355\u6297\u5728\u5404\u7c7b\u5b9e\u4f53\u80bf\u7624\u548c\u8840\u6db2\u80bf\u7624\u4e0a\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u56db\u9879\u9002\u5e94\u75c7\u5e76\u6210\u529f\u7eb3\u5165\u4e2d\u56fd\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\uff0c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u7528\u4e8e\u6cbb\u7597\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff1b <\/li>\n<li>\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u5316\u7597\u7528\u4e8eEGFR\u6216ALK\u9634\u6027\u7684\u665a\u671f\u975e\u9cde\u72b6NSCLC\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b <\/li>\n<li>\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u548c\u94c2\u7c7b\u5316\u7597\u9002\u7528\u4e8e\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6NSCLC\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b <\/li>\n<li>\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7528\u4e8e\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<\/li>\n<\/ul>\n<p>\u53e6\u5916\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u6709\u4e09\u9879\u9002\u5e94\u75c7\u7684\u4e0a\u5e02\u7533\u8bf7\u5df2\u83b7\u4e2d\u56fd\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\u5ba1\u8bc4\uff0c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u8054\u5408\u987a\u94c2\u548c\u7d2b\u6749\u9187\/\u987a\u94c2\u548c5-\u6c1f\u5c3f\u5627\u5576\u7528\u4e8e\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b <\/li>\n<li>\u8054\u5408\u5965\u6c99\u5229\u94c2\u548c\u5361\u57f9\u4ed6\u6ee8\u4e00\u7ebf\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u817a\u764c\uff1b <\/li>\n<li>\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u53ca\u5316\u7597\u7528\u4e8e\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKI\uff09\u6cbb\u7597\u5931\u8d25\u7684EGFR\u7a81\u53d8\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/li>\n<\/ul>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\u53e6\u6709\u4e24\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u5230\u7814\u7a76\u7ec8\u70b9\uff0c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u5355\u836f\u7528\u4e8e\u665a\u671f\/\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684\u4e8c\u671f\u4e34\u5e8a\u7814\u7a76\uff1b <\/li>\n<li>\u5355\u836f\u7528\u4e8e\u542b\u94c2\u5316\u7597\u5931\u8d25\u7684\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684\u4e09\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/li>\n<\/ul>\n<p>2021\u5e745\u6708\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u7528\u4e8e\u975e\u9cde\u72b6NSCLC\u4e00\u7ebf\u6cbb\u7597\u7684\u4e0a\u5e02\u7533\u8bf7\u5df2\u83b7\u7f8e\u56fdFDA\u6b63\u5f0f\u53d7\u7406\u5ba1\u8bc4\u3002<\/p>\n<p><b>\u5173\u4e8e\u8fbe\u6538\u540c<\/b><b>&reg;<\/b><b>\uff08\u8d1d\u4f10\u73e0\u5355\u6297\uff09<\/b><\/p>\n<p>\u8fbe\u6538\u540c<sup>&reg;<\/sup>\u4e3a\u8d1d\u4f10\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u53c8\u540d\u91cd\u7ec4\u6297VEGF\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\u3002VEGF\u662f\u4e00\u79cd\u8840\u7ba1\u751f\u6210\u8fc7\u7a0b\u4e2d\u91cd\u8981\u7684\u56e0\u5b50\uff0c\u5728\u591a\u6570\u4eba\u7c7b\u80bf\u7624\u5185\u76ae\u7ec6\u80de\u4e2d\u8fc7\u5ea6\u75c5\u7406\u8868\u8fbe\u3002\u6297VEGF\u6297\u4f53\uff0c\u53ef\u4ee5\u9ad8\u4eb2\u548c\u529b\u5730\u9009\u62e9\u6027\u7ed3\u5408VEGF\uff0c\u901a\u8fc7\u963b\u65adVEGF\u4e0e\u5176\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u8868\u9762\u4e0a\u7684\u53d7\u4f53\u7ed3\u5408\uff0c\u963b\u65adPI3K-Akt\/PKB\u548cRas-Raf-MEK-ERK\u7b49\u4fe1\u53f7\u901a\u8def\u7684\u4f20\u5bfc\uff0c\u4ece\u800c\u6291\u5236\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u751f\u957f\u3001\u589e\u6b96\u3001\u8fc1\u79fb\u4ee5\u53ca\u8840\u7ba1\u65b0\u751f\uff0c\u964d\u4f4e\u8840\u7ba1\u6e17\u900f\u6027\uff0c\u963b\u65ad\u80bf\u7624\u7ec4\u7ec7\u7684\u8840\u6db2\u4f9b\u5e94\uff0c\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u589e\u6b96\u548c\u8f6c\u79fb\uff0c\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\uff0c\u4ece\u800c\u8fbe\u5230\u6297\u80bf\u7624\u7684\u6cbb\u7597\u6548\u679c\u3002\u539f\u7814\u836f\u8d1d\u4f10\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\u81ea\u4e0a\u5e02\u4ee5\u6765\uff0c\u5168\u7403\u5df2\u83b7\u6279\u5176\u7528\u4e8e\u6cbb\u7597\u5305\u62ec\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3001\u80be\u7ec6\u80de\u764c\u3001\u5bab\u9888\u764c\u3001\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u3001\u8179\u819c\u764c\u7b49\u591a\u4e2a\u5b9e\u4f53\u7624\uff0c\u5176\u663e\u8457\u7684\u7597\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u5df2\u5f97\u5230\u666e\u904d\u8ba4\u53ef\u3002\u5728\u4e2d\u56fd\uff0c\u8fbe\u6538\u540c<sup>&reg;<\/sup>\u5df2\u83b7\u6279\u5305\u62ec\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u3001\u6210\u4eba\u590d\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u548c\u809d\u7ec6\u80de\u764c\u6cbb\u7597\u7b49\u9002\u5e94\u75c7\u3002<\/p>\n<p><b>\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n<p>\u201c\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c\u201d\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u7406\u60f3\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u30022018\u5e7410\u670831\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a01801\u3002<\/p>\n<p>\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u516c\u53f8\u51ed\u501f\u521b\u65b0\u6210\u679c\u548c\u56fd\u9645\u5316\u7684\u8fd0\u8425\u6a21\u5f0f\u5728\u4f17\u591a\u751f\u7269\u5236\u836f\u516c\u53f8\u4e2d\u8131\u9896\u800c\u51fa\u3002\u5efa\u7acb\u8d77\u4e86\u4e00\u6761\u5305\u62ec26\u4e2a\u65b0\u836f\u54c1\u79cd\u7684\u4ea7\u54c1\u94fe\uff0c\u8986\u76d6\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u591a\u4e2a\u75be\u75c5\u9886\u57df\uff0c\u5176\u4e2d7\u4e2a\u54c1\u79cd\u5165\u9009\u56fd\u5bb6\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u4e13\u9879\u3002\u516c\u53f8\u5df2\u67096\u4e2a\u4ea7\u54c1\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aTYVYT<sup>&reg;<\/sup>\uff1b\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u6538\u540c<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aBYVASDA<sup>&reg;<\/sup>\uff1b\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u82cf\u7acb\u4fe1<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aSULINNO<sup>&reg;<\/sup>\uff1b\u5229\u59a5\u6614\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u534e<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aHALPRYZA<sup>&reg;<\/sup>\uff1bpemigatinib\u53e3\u670d\u6291\u5236\u5242\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u5766<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aPEMAZYRE<sup>&reg;<\/sup>\uff1b\u5965\u96f7\u5df4\u66ff\u5c3c\u7247\uff0c\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b<sup>&reg;<\/sup>\uff09\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u5728\u7f8e\u56fd\u7684\u4e0a\u5e02\u7533\u8bf7\u83b7FDA\u53d7\u7406\uff0c5\u4e2a\u54c1\u79cd\u8fdb\u5165III\u671f\u6216\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u8fd8\u670915\u4e2a\u4ea7\u54c1\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u4fe1\u8fbe\u751f\u7269\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u5177\u6709\u56fd\u9645\u5148\u8fdb\u6c34\u5e73\u7684\u9ad8\u7aef\u751f\u7269\u836f\u5f00\u53d1\u3001\u4ea7\u4e1a\u5316\u4eba\u624d\u56e2\u961f\uff0c\u5305\u62ec\u4f17\u591a\u6d77\u5f52\u4e13\u5bb6\uff0c\u5e76\u4e0e\u7f8e\u56fd\u793c\u6765\u5236\u836f\u3001Adimab\u3001Incyte\u3001MD Anderson \u764c\u75c7\u4e2d\u5fc3\u548c\u97e9\u56fdHanmi\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1a<a target=\"_blank\" href=\"http:\/\/www.innoventbio.com\/\" rel=\"nofollow noopener\">www.innoventbio.com<\/a>\u6216\u516c\u53f8\u9886\u82f1\u8d26\u53f7<a target=\"_blank\" href=\"http:\/\/www.linkedin.com\/company\/innovent-biologics\/\" rel=\"nofollow noopener\">www.linkedin.com\/company\/innovent-biologics\/<\/a>\u3002<\/p>\n<p><b>\u5173\u4e8e\u793c\u6765\u5236\u836f<\/b><\/p>\n<p>\u793c\u6765\u5236\u836f\u662f\u4e00\u5bb6\u5168\u7403\u9886\u5148\u7684\u533b\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u901a\u8fc7\u521b\u65b0\u6539\u5584\u4eba\u7c7b\u5065\u5eb7\u6c34\u5e73\u3002\u793c\u6765\u5236\u836f\u8bde\u751f\u4e8e\u4e00\u4e2a\u591a\u4e16\u7eaa\u4e4b\u524d\uff0c\u516c\u53f8\u521b\u59cb\u4eba\u81f4\u529b\u4e8e\u751f\u4ea7\u9ad8\u8d28\u91cf\u7684\u836f\u54c1\u4ee5\u6ee1\u8db3\u5207\u5b9e\u7684\u533b\u7597\u9700\u6c42\u3002\u4eca\u5929\uff0c\u6211\u4eec\u4ecd\u7136\u6267\u7740\u4e8e\u8fd9\u4e00\u4f7f\u547d\uff0c\u5e76\u57fa\u4e8e\u6b64\u5f00\u5c55\u5de5\u4f5c\u3002\u5728\u5168\u7403\u8303\u56f4\u5185\uff0c\u6211\u4eec\u7684\u5458\u5de5\u59cb\u7ec8\u52aa\u529b\u7814\u53d1\u80fd\u4e3a\u4eba\u7c7b\u751f\u6d3b\u5e26\u6765\u6539\u53d8\u7684\u836f\u7269\uff0c\u5e76\u5c06\u5176\u63d0\u4f9b\u7ed9\u90a3\u4e9b\u5207\u5b9e\u6240\u9700\u7684\u60a3\u8005\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u6211\u4eec\u8fd8\u81f4\u529b\u4e8e\u6539\u5584\u516c\u4f17\u5bf9\u4e8e\u75be\u75c5\u7684\u7406\u89e3\u3001\u5e76\u66f4\u597d\u5730\u5f00\u5c55\u75be\u75c5\u7ba1\u7406\uff0c\u540c\u65f6\u901a\u8fc7\u6295\u8eab\u4e8e\u6148\u5584\u4e8b\u4e1a\u548c\u5fd7\u613f\u8005\u6d3b\u52a8\u56de\u9988\u793e\u4f1a\u3002\u5982\u679c\u9700\u8981\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u793c\u6765\u5236\u836f\u7684\u4fe1\u606f\uff0c\u8bf7\u767b\u5f55\uff1a<a target=\"_blank\" href=\"http:\/\/www.lilly.com\/\" rel=\"nofollow noopener\">www.lilly.com<\/a>\u3002<\/p>\n<p><b>\u5173\u4e8e\u793c\u6765\u5236\u836f\u548c\u4fe1\u8fbe\u751f\u7269\u7684\u6218\u7565\u5408\u4f5c<\/b><\/p>\n<p>\u793c\u6765\u5236\u836f\u548c\u4fe1\u8fbe\u751f\u7269\u4e8e2015\u5e743\u6708\u8fbe\u6210\u4e86\u4e00\u9879\u751f\u7269\u6280\u672f\u836f\u7269\u5f00\u53d1\u5408\u4f5c\uff0c\u8be5\u5408\u4f5c\u4ea6\u662f\u8fc4\u4eca\u4e3a\u6b62\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4f01\u4e1a\u4e0e\u8de8\u56fd\u836f\u4f01\u4e4b\u95f4\u6700\u5927\u7684\u5408\u4f5c\u4e4b\u4e00\u3002\u6839\u636e\u5408\u4f5c\u6761\u6b3e\uff0c\u793c\u6765\u5236\u836f\u548c\u4fe1\u8fbe\u751f\u7269\u5c06\u5728\u4e2d\u56fd\u5171\u540c\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u5305\u62ec\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u5728\u5185\u7684\u80bf\u7624\u836f\u7269\u30022015\u5e7410\u6708\uff0c\u53cc\u65b9\u5ba3\u5e03\u518d\u6b21\u62d3\u5c55\u5df2\u5efa\u7acb\u7684\u836f\u7269\u5f00\u53d1\u5408\u4f5c\uff0c\u589e\u52a0\u4e09\u4e2a\u65b0\u578b\u80bf\u7624\u6cbb\u7597\u6297\u4f53\u30022019\u5e748\u6708\uff0c\u53cc\u65b9\u5408\u4f5c\u6269\u5c55\u81f3\u7cd6\u5c3f\u75c5\u9886\u57df\uff0c\u4fe1\u8fbe\u751f\u7269\u83b7\u6388\u6743\u5728\u4e2d\u56fd\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u793c\u6765\u7684\u4e00\u4e2a\u6f5c\u5728\u5168\u7403\u6700\u4f73\u65b0\u578b\u4e34\u5e8a\u9636\u6bb5\u7cd6\u5c3f\u75c5\u836f\u7269\u3002\u8fd9\u4e09\u6b21\u4e0e\u793c\u6765\u5236\u836f\u7684\u5408\u4f5c\u6807\u5fd7\u7740\u4fe1\u8fbe\u751f\u7269\u5df2\u5efa\u7acb\u8d77\u4e00\u4e2a\u7531\u4e2d\u56fd\u521b\u65b0\u836f\u4f01\u4e0e\u5168\u7403\u5236\u836f\u5de8\u5934\u4e4b\u95f4\u7684\u5168\u9762\u6218\u7565\u5408\u4f5c\uff0c\u5176\u8303\u56f4\u6db5\u76d6\u65b0\u836f\u7814\u53d1\uff0c\u4e34\u5e8a\u7814\u7a76\uff0c\u751f\u4ea7\u8d28\u91cf\u548c\u5e02\u573a\u9500\u552e\u7b49\u3002<\/p>\n<p><i>\u58f0\u660e\uff1a<br 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