{"id":60929,"date":"2022-01-20T17:00:00","date_gmt":"2022-01-20T10:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022012017000060929"},"modified":"2022-01-21T18:10:16","modified_gmt":"2022-01-21T10:10:16","slug":"%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9e%e5%ae%a3%e5%b8%83%e7%99%be%e6%82%a6%e6%b3%bd%ef%bc%88%e6%b3%bd%e5%b8%83%e6%9b%bf%e5%b0%bc%ef%bc%89%e7%94%a8%e4%ba%8e%e5%88%9d%e6%b2%bb%e5%8d%8e%e6%b0%8f","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022012017000060929","title":{"rendered":"\u767e\u6d4e\u795e\u5dde\u5ba3\u5e03\u767e\u60a6\u6cfd\u00ae\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u7528\u4e8e\u521d\u6cbb\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u5728\u4e2d\u56fd\u83b7\u5f97\u53d7\u7406"},"content":{"rendered":"<p><p><span class=\"xn-subheadline\">\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u5df2\u4e8e2021\u5e746\u6708\u6279\u51c6\u767e\u60a6\u6cfd\u00ae\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u60a3\u8005<\/span><\/p>\n<p><span class=\"xn-subheadline\">\u6b64\u6b21\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u662f\u57fa\u4e8eASPEN\u8bd5\u9a8c\u7ed3\u679c\uff0c\u6709\u671b\u5c06\u767e\u60a6\u6cfd\u00ae\u7684\u9002\u7528\u8303\u56f4\u62d3\u5c55\u81f3\u4e00\u7ebfWM<\/span><\/p>\n<p>\u4e2d\u56fd\u5317\u4eac\u548c\u7f8e\u56fd\u9ebb\u7701\u5251\u68652022\u5e741\u670820\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u767e\u6d4e\u795e\u5dde\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff1b\u4e0a\u4ea4\u6240\u4ee3\u7801<span id=\"spanHghlt5e4d\">\uff1a<\/span>688235\uff09\uff0c\u662f\u4e00\u5bb6\u7acb\u8db3\u79d1\u5b66\u7684\u5168\u7403\u6027\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5728\u4e16\u754c\u8303\u56f4\u5185\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u521b\u65b0\u836f\u7269\uff0c\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u6548\u679c\u548c\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u516c\u53f8\u4eca\u65e5\u5ba3\u5e03\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u5df2\u53d7\u7406\u5176BTK\u6291\u5236\u5242\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u7528\u4e8e\u6cbb\u7597\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u6210\u4eba\u60a3\u8005\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\uff08sNDA\uff09\u3002<\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u8840\u6db2\u5b66\u9996\u5e2d\u533b\u5b66\u5b98\u9ec4\u851a\u5a1f\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u767e\u60a6\u6cfd<b><sup>&reg;<\/sup><\/b>\u7ee7\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u60a3\u8005\u540e\uff0c\u6b64\u6b21sNDA\u7533\u8bf7\u4e5f\u83b7\u5f97NMPA\u53d7\u7406\uff0c\u8fd9\u5bf9\u6211\u4eec\u6765\u8bf4\u662f\u4e00\u4e2a\u597d\u6d88\u606f\u3002\u8fd9\u610f\u5473\u7740\u4e00\u65e6\u53d6\u5f97\u6279\u51c6\uff0c\u66f4\u591a\u4e2d\u56fd\u7684\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u60a3\u8005\u5c06\u6709\u673a\u4f1a\u7528\u4e0a\u8fd9\u6b3e\u836f\u7269\u3002ASPEN\u8bd5\u9a8c\u8868\u660e\uff0c\u767e\u60a6\u6cfd<b><sup>&reg;<\/sup><\/b>\u5bf9WM\u60a3\u8005\u800c\u8a00\u662f\u4e00\u9879\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u5f15\u8d77\u623f\u98a4\u7b49\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u7684\u98ce\u9669\u66f4\u4f4e\u3002\u5728ASPEN\u8bd5\u9a8c\u6570\u636e\u7684\u652f\u6301\u4e0b\uff0c\u767e\u60a6\u6cfd<b><sup>&reg;<\/sup><\/b>\u5df2\u7ecf\u5728\u7f8e\u56fd\u3001\u52a0\u62ff\u5927\u3001\u6fb3\u5927\u5229\u4e9a\u548c\u6b27\u76df\u83b7\u6279\u7528\u4e8eWM\u60a3\u8005\u7684\u6cbb\u7597\u6211\u4eec\u671f\u5f85\u4e0eCDE\u7ee7\u7eed\u63a2\u8ba8\uff0c\u4e89\u53d6\u5c06\u8fd9\u4e00\u5177\u5907\u2018\u540c\u7c7b\u6700\u4f18\u2019\u6f5c\u529b\u7684\u836f\u7269\u63d0\u4f9b\u7ed9\u66f4\u591a\u4e2d\u56fdWM\u60a3\u8005\u7684\u673a\u4f1a\u3002\u201d&nbsp;<\/p>\n<p>\u6b64\u6b21sNDA\u7533\u8bf7\u57fa\u4e8eASPEN\u8bd5\u9a8c\u6570\u636e\uff0c\u8fd9\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT03053400\uff09\uff0c\u5bf9\u6bd4\u4e86\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u4e0e\u4f0a\u5e03\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\uff08R\/R\uff09\u6216\u521d\u6cbb\uff08TN\uff09WM\u60a3\u8005\u7684\u6570\u636e\u3002<\/p>\n<p>\u7ecf\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRC\uff09\u6839\u636e\u7b2c\u516d\u5c4a\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u56fd\u9645\u7814\u8ba8\u4f1a\uff08IWWM-6\uff09\u4fee\u8ba2\u7248\u7f13\u89e3\u6807\u51c6\uff08Treon 2015\uff09\u8bc4\u4f30\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u6cbb\u7597\u7ec4\u5728\u603b\u4f53\u610f\u5411\u6027\u6cbb\u7597\uff08ITT\uff09\u4eba\u7fa4\u4e2d\u7684\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u548c\u975e\u5e38\u597d\u7684\u90e8\u5206\u7f13\u89e3\uff08VGPR\uff09\u7387\u7684\u7efc\u5408\u4e3a28%\uff0895%&nbsp;CI\uff1a20\uff0c38\uff09\uff0c\u800c\u4f0a\u5e03\u66ff\u5c3c\u7ec4\u4e3a19%\uff0895%&nbsp;CI\uff1a12\uff0c28\uff09\u3002\u5c3d\u7ba1\u4e24\u7ec4\u6570\u636e\u7684\u5dee\u5f02\u672a\u8fbe\u5230\u7edf\u8ba1\u5b66\u663e\u8457\u6027\uff08<i>p=<\/i>0.09\uff09\uff0c\u4f46\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5c55\u73b0\u4e86\u66f4\u9ad8\u7684VGPR\u7387\u6570\u636e\uff0c\u4e14\u7f13\u89e3\u8d28\u91cf\u5448\u73b0\u51fa\u6539\u5584\u8d8b\u52bf\u3002<sup><span id=\"spanHghltc00f\">[1]<\/span><\/sup> <\/p>\n<p>\u5728ASPEN\u8bd5\u9a8c\u4e2d\uff0c\u4e0e\u4f0a\u5e03\u66ff\u5c3c\u76f8\u6bd4\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u53d6\u5f97\u4e86\u66f4\u5177\u4f18\u52bf\u7684\u5b89\u5168\u6027\u6570\u636e\uff0c\u7279\u5b9a\u4e0d\u826f\u4e8b\u4ef6\u7684\u53d1\u751f\u7387\u8f83\u66f4\u4f4e\uff0c\u5305\u62ec\u623f\u98a4\/\u623f\u6251\uff082% vs. 15%\uff09\u548c\u5927\u51fa\u8840\uff086% vs. 9%\uff09\u3002\u5728101\u4f8b\u63a5\u53d7\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u6cbb\u7597\u7684WM\u60a3\u8005\u4e2d\uff0c4%\u7684\u60a3\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u800c\u7ec8\u6b62\u6cbb\u7597\uff0c14%\u7684\u60a3\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u964d\u4f4e\u7528\u836f\u5242\u91cf\u3002<sup><span id=\"spanHghlta23c\">[4]<\/span><\/sup><\/p>\n<p><b>\u5173\u4e8e\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7<\/b><\/p>\n<p>\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u662f\u4e00\u79cd\u7f55\u89c1\u60f0\u6027\u6dcb\u5df4\u7624\uff0c\u5728\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u60a3\u8005\u4e2d\u5360\u6bd4\u4e0d\u52302%\u3002<sup><span id=\"spanHghltcee0\">[1]<\/span><\/sup>&nbsp;\u8be5\u75be\u75c5\u901a\u5e38\u5728\u8001\u5e74\u4eba\u4e2d\u591a\u53d1\uff0c\u4e3b\u8981\u5728\u9aa8\u9ad3\u4e2d\u53d1\u73b0\uff0c\u4f46\u4e5f\u53ef\u80fd\u7d2f\u53ca\u6dcb\u5df4\u7ed3\u548c\u813e\u810f\u3002<sup><span id=\"spanHghlt2397\">[2]<\/span><\/sup>&nbsp;\u5728\u4e2d\u56fd\uff0c\u6bcf\u5e74\u5927\u7ea6\u670988,200\u4f8b\u6dcb\u5df4\u7624\u65b0\u589e\u75c5\u4f8b\uff0c\u5176\u4e2d\u7ea6\u670991%\u4e3aNHL\uff0c\u8fd9\u610f\u5473\u7740\u6211\u56fd\u6bcf\u5e74\u7ea6\u67091000\u4f8bWM\u65b0\u589e\u75c5\u4f8b\u3002<sup><span id=\"spanHghlt3647\">[3]<\/span><\/sup><\/p>\n<p><b>\u5173\u4e8e\u767e\u60a6\u6cfd<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09<\/b><\/p>\n<p>\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u662f\u4e00\u6b3e\u7531\u767e\u6d4e\u795e\u5dde\u79d1\u5b66\u5bb6\u81ea\u4e3b\u7814\u53d1\u7684\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u76ee\u524d\u6b63\u5728\u5168\u7403\u8fdb\u884c\u5e7f\u6cdb\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9879\u76ee\uff0c\u4f5c\u4e3a\u5355\u836f\u548c\u4e0e\u5176\u4ed6\u7597\u6cd5\u8054\u5408\u7528\u836f\u6cbb\u7597\u591a\u79cdB\u7ec6\u80de\u6076\u6027\u80bf\u7624\u3002\u7531\u4e8e\u65b0\u7684BTK\u4f1a\u5728\u4eba\u4f53\u5185\u4e0d\u65ad\u5408\u6210\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u7684\u8bbe\u8ba1\u901a\u8fc7\u4f18\u5316\u751f\u7269\u5229\u7528\u5ea6\u3001\u534a\u8870\u671f\u548c\u9009\u62e9\u6027\uff0c\u5b9e\u73b0\u5bf9BTK\u86cb\u767d\u5b8c\u5168\u3001\u6301\u7eed\u7684\u6291\u5236\u3002\u51ed\u501f\u4e0e\u5176\u4ed6\u83b7\u6279BTK\u6291\u5236\u5242\u5b58\u5728\u5dee\u5f02\u5316\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u80fd\u5728\u591a\u4e2a\u75be\u75c5\u76f8\u5173\u7ec4\u7ec7\u4e2d\u6291\u5236\u6076\u6027B\u7ec6\u80de\u589e\u6b96\u3002<\/p>\n<p>\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5df2\u5728\u4ee5\u4e0b\u5730\u533a\u4e2d\u83b7\u6279\u5982\u4e0b\u9002\u5e94\u75c7\uff1a<\/p>\n<ul type=\"disc\">\n<li>2019\u5e7411\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005* <\/li>\n<li>2020\u5e746\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684MCL\u60a3\u8005** <\/li>\n<li>2020\u5e746\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74\u6162\u6027\u6dcb\u5df4\u7ec6\u80de&nbsp;\u767d\u8840\u75c5\uff08CLL\uff09\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09\u60a3\u8005** <\/li>\n<li>2021\u5e742\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u963f\u62c9\u4f2f\u8054\u5408\u914b\u957f\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027MCL\u60a3\u8005 <\/li>\n<li>2021\u5e743\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u52a0\u62ff\u5927\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u6210\u5e74\u60a3\u8005 <\/li>\n<li>2021\u5e746\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684WM\u6210\u5e74\u60a3\u8005** <\/li>\n<li>2021\u5e747\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u52a0\u62ff\u5927\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74MCL\u60a3\u8005** <\/li>\n<li>2021\u5e747\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u667a\u5229\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74MCL\u60a3\u8005** <\/li>\n<li>2021\u5e748\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u5df4\u897f\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684MCL\u6210\u5e74\u60a3\u8005 <\/li>\n<li>2021\u5e748\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u6210\u5e74WM\u60a3\u8005&nbsp; <\/li>\n<li>2021\u5e749\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u9879\u6297CD20\u7597\u6cd5\u7684\u6210\u5e74\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff08MZL\uff09\u60a3\u8005* <\/li>\n<li>2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u65b0\u52a0\u5761\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684MCL\u6210\u5e74\u60a3\u8005&nbsp; <\/li>\n<li>2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4ee5\u8272\u5217\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74MCL\u60a3\u8005 <\/li>\n<li>2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u6fb3\u5927\u5229\u4e9a\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74WM\u60a3\u8005\u6216\u4f5c\u4e3a\u4e0d\u9002\u5408\u5316\u5b66\u514d\u75ab\u7597\u6cd5WM\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848&nbsp; <\/li>\n<li>2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u6fb3\u5927\u5229\u4e9a\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u6cbb\u7597\u7684MCL\u6210\u5e74\u60a3\u8005\uff0c <\/li>\n<li>2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4fc4\u7f57\u65af\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684MCL\u6210\u5e74\u60a3\u8005&nbsp; <\/li>\n<li>2021\u5e7411\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u6c99\u7279\u963f\u62c9\u4f2f\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e7411\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u6b27\u76df\u3001\u51b0\u5c9b\u3001\u5217\u652f\u6566\u58eb\u767b\u548c\u632a\u5a01\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u7597\u6cd5\u7684\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u6210\u4eba\u60a3\u8005\uff0c\u6216\u4f5c\u4e3a\u4e00\u7ebf\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u4e0d\u9002\u5408\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u7684\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e7412\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u82f1\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u7597\u6cd5\u7684\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u6210\u4eba\u60a3\u8005\uff0c\u6216\u4f5c\u4e3a\u4e00\u7ebf\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u4e0d\u9002\u5408\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u7684\u60a3\u8005\uff1b <\/li>\n<li>2021\u5e7412\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u5384\u74dc\u591a\u5c14\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u7597\u6cd5\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u3002<\/li>\n<\/ul>\n<p>\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5df2\u9012\u4ea4\u8d85\u8fc730\u4e2a\u9488\u5bf9\u591a\u9879\u9002\u5e94\u75c7\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u8986\u76d6\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u6b27\u76df\u548c\u5176\u4ed620\u591a\u4e2a\u56fd\u5bb6\u6216\u5730\u533a\u3002<\/p>\n<p>*\u8be5\u9879\u9002\u5e94\u75c7\u57fa\u4e8e\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u83b7\u5f97\u52a0\u901f\u6279\u51c6\u3002\u9488\u5bf9\u8be5\u9002\u5e94\u75c7\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u9a8c\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u4e34\u5e8a\u83b7\u76ca\u7684\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002<\/p>\n<p>**\u8be5\u9879\u9002\u5e94\u75c7\u83b7\u9644\u6761\u4ef6\u6279\u51c6\u3002\u9488\u5bf9\u8be5\u9002\u5e94\u75c7\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u6b63\u5728\u5f00\u5c55\u7684\u786e\u8bc1\u6027\u968f\u673a\u3001\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3002<\/p>\n<p><b>\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66<\/b><\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u6216\u4e0e\u5fd7\u540c\u9053\u5408\u7684\u5408\u4f5c\u4f19\u4f34\u643a\u624b\uff0c\u4e0d\u65ad\u63a8\u52a8\u540c\u7c7b\u6700\u4f73\u6216\u540c\u7c7b\u7b2c\u4e00\u7684\u4e34\u5e8a\u5019\u9009\u836f\u7269\u7814\u53d1\uff0c\u81f4\u529b\u4e8e\u4e3a\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u6709\u5f71\u54cd\u529b\u3001\u53ef\u53ca\u4e14\u53ef\u8d1f\u62c5\u7684\u836f\u7269\u3002\u516c\u53f8\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u548c\u5f00\u53d1\u56e2\u961f\u5df2\u6709\u7ea62300\u4eba\uff0c\u56e2\u961f\u89c4\u6a21\u8fd8\u5728\u4e0d\u65ad\u6269\u5927\u3002\u8fd9\u652f\u56e2\u961f\u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u56f4\u652f\u6301\u5f00\u5c5590\u591a\u9879\u4e34\u5e8a\u7814\u7a76\uff0c\u5df2\u62db\u52df\u60a3\u8005\u548c\u5065\u5eb7\u53d7\u8bd5\u8005\u8d85\u8fc713000\u4eba\u3002\u767e\u6d4e\u795e\u5dde\u81ea\u6709\u7684\u4e34\u5e8a\u5f00\u53d1\u56e2\u961f\u89c4\u5212\u5e76\u4e3b\u5bfc\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u7684\u7814\u53d1\u548c\u6269\u5145\uff0c\u4e3a\u8986\u76d6\u5168\u740340\u591a\u4e2a\u56fd\u5bb6\/\u5730\u533a\u7684\u4e34\u5e8a\u8bd5\u9a8c\u63d0\u4f9b\u652f\u6301\u548c\u6307\u5bfc\u3002\u76ee\u524d\uff0c\u767e\u6d4e\u795e\u5dde\u81ea\u4e3b\u7814\u53d1\u7684\u4e09\u6b3e\u836f\u7269\u5df2\u83b7\u6279\u4e0a\u5e02\uff1a\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\uff08BTK\u6291\u5236\u5242\uff0c\u5df2\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u52a0\u62ff\u5927\u53ca\u5176\u4ed6\u56fd\u9645\u5e02\u573a\u83b7\u6279\u4e0a\u5e02\uff09\u3001\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\uff08\u53ef\u6709\u6548\u907f\u514dFc-\u03b3\u53d7\u4f53\u7ed3\u5408\u7684\u6297PD-1\u6297\u4f53\uff0c\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff09\u53ca\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\uff08\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff09\u3002\u767e\u6d4e\u795e\u5dde\u62e5\u6709\u4e00\u652f\u8ffd\u6c42\u9ad8\u54c1\u8d28\u4e0e\u521b\u65b0\u3001\u7acb\u8db3\u79d1\u5b66\u4e0e\u533b\u5b66\u7684\u56e2\u961f\uff0c\u5e76\u5728\u4e2d\u56fd\u5efa\u7acb\u4e86\u9886\u5148\u5730\u4f4d\uff0c\u6253\u9020\u4e86\u4e00\u652f\u89c4\u6a21\u5e9e\u5927\u3001\u805a\u7126\u4e8e\u80bf\u7624\u5b66\u7684\u5546\u4e1a\u56e2\u961f\u3002&nbsp;<\/p>\n<p>\u540c\u65f6\uff0c\u767e\u6d4e\u795e\u5dde\u8fd8\u4e0e\u5176\u4ed6\u521b\u65b0\u516c\u53f8\u5408\u4f5c\uff0c\u5171\u540c\u643a\u624b\u63a8\u8fdb\u521b\u65b0\u7597\u6cd5\u7684\u7814\u53d1\uff0c\u4ee5\u6ee1\u8db3\u5168\u7403\u5065\u5eb7\u9700\u6c42\u3002\u5728\u4e2d\u56fd\uff0c\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u9500\u552e\u591a\u6b3e\u7531\u5b89\u8fdb\u548c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u6388\u6743\u7684\u80bf\u7624\u836f\u7269\u3002\u516c\u53f8\u4e5f\u901a\u8fc7\u4e0e\u5305\u62ec\u5b89\u8fdb\u3001\u767e\u5965\u6cf0\u3001EUSA Pharma\u3001Mirati Therapeutics\u3001Seagen \u4ee5\u53ca&nbsp;Zymeworks \u5728\u5185\u7684\u591a\u5bb6\u516c\u53f8\u5408\u4f5c\uff0c\u66f4\u5927\u7a0b\u5ea6\u6ee1\u8db3\u5f53\u524d\u5168\u7403\u8303\u56f4\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002\u767e\u6d4e\u795e\u5dde\u8fd8\u4e0e\u8bfa\u534e\u516c\u53f8\u8fbe\u6210\u5408\u4f5c\uff0c\u6388\u6743\u8bfa\u534e\u5728\u5317\u7f8e\u3001\u6b27\u6d32\u548c\u65e5\u672c\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u3002<\/p>\n<p><b>\u5173\u4e8e\u767e\u6d4e\u795e\u5dde<\/b><\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u662f\u4e00\u5bb6\u7acb\u8db3\u79d1\u5b66\u7684\u5168\u7403\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u521b\u65b0\u3001\u53ef\u8d1f\u62c5\u7684\u836f\u7269\uff0c\u4ee5\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u6548\u679c\u548c\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u76ee\u524d\u516c\u53f8\u5e7f\u6cdb\u7684\u836f\u7269\u7ec4\u5408\u5305\u62ec40\u591a\u6b3e\u4e34\u5e8a\u5019\u9009\u836f\u7269\u3002\u516c\u53f8\u901a\u8fc7\u52a0\u5f3a\u81ea\u4e3b\u7814\u53d1\u80fd\u529b\u548c\u5408\u4f5c\uff0c\u52a0\u901f\u63a8\u8fdb\u591a\u5143\u3001\u521b\u65b0\u7684\u836f\u7269\u7ba1\u7ebf\u5f00\u53d1\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u57282030\u5e74\u524d\u4e3a\u5168\u740320\u591a\u4ebf\u4eba\u5168\u9762\u6539\u5584\u836f\u7269\u53ef\u53ca\u6027\u3002\u767e\u6d4e\u795e\u5dde\u5728\u5168\u7403\u4e94\u5927\u6d32\u6253\u9020\u4e86\u4e00\u652f\u8d85\u8fc78000\u4eba\u7684\u56e2\u961f\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a target=\"_blank\" href=\"http:\/\/www.beigene.com.cn\/\" rel=\"nofollow noopener\">www.beigene.com.cn<\/a>\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p><span id=\"spanHghlt831e\">\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u6839\u636e\u300a1995\u5e74\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 1995\uff09\u4ee5\u53ca\u5176\u4ed6\u8054\u90a6\u8bc1\u5238\u6cd5\u5f8b\u4e0b\u5b9a\u4e49\u7684\u524d\u77bb\u6027\u58f0\u660e\uff0c\u5305\u62ec\u5173\u4e8e\u4e0e\u5176\u4ed6BTK\u6291\u5236\u5242\u76f8\u6bd4\uff0c\u767e\u60a6\u6cfd&reg;\u7684\u6f5c\u5728\u4e34\u5e8a\u76ca\u5904\u548c\u4f18\u52bf\u7684\u58f0\u660e\uff0c\u767e\u6d4e\u795e\u5dde\u8ba1\u5212\u7684\u8fdb\u5c55\uff0c\u767e\u6d4e\u795e\u5dde\u5bf9\u767e\u60a6\u6cfd&reg;\u9884\u671f\u7684\u4e34\u5e8a\u5f00\u53d1\u3001\u836f\u653f\u91cc\u7a0b\u7891\u548c\u5546\u4e1a\u5316\u8fdb\u7a0b\uff0c\u767e\u60a6\u6cfd&reg;\u6f5c\u5728\u5546\u4e1a\u673a\u4f1a\uff0c\u5728\u4e2d\u56fd\u63d0\u9ad8\u767e\u60a6\u6cfd&reg;\u53ef\u53ca\u6027\u7684\u8ba1\u5212\uff0c\u767e\u60a6\u6cfd&reg;\u4e3a\u6f5c\u5728\u540c\u7c7b\u6700\u4f18BTK\u6291\u5236\u5242\uff0c\u767e\u60a6\u6cfd&reg;\u5bf9\u60a3\u8005\u7684\u6f5c\u5728\u4e34\u5e8a\u83b7\u76ca\u4ee5\u53ca\u5728\u201c\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66\u201d\u548c\u201c\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u201d\u526f\u6807\u9898\u4e0b\u63d0\u53ca\u7684\u767e\u6d4e\u795e\u5dde\u8ba1\u5212\u3001\u627f\u8bfa\u3001\u62b1\u8d1f\u548c\u76ee\u6807\u3002\u7531\u4e8e\u5404\u79cd\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u58f0\u660e\u6709\u91cd\u5927\u5dee\u5f02\u3002\u8fd9\u4e9b\u56e0\u7d20\u5305\u62ec\u4e86\u4ee5\u4e0b\u4e8b\u9879\u7684\u98ce\u9669\uff1a\u767e\u6d4e\u795e\u5dde\u8bc1\u660e\u5176\u5019\u9009\u836f\u7269\u529f\u6548\u548c\u5b89\u5168\u6027\u7684\u80fd\u529b\uff1b\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u7ed3\u679c\u53ef\u80fd\u4e0d\u652f\u6301\u8fdb\u4e00\u6b65\u5f00\u53d1\u6216\u4e0a\u5e02\u5ba1\u6279\uff1b\u836f\u76d1\u90e8\u95e8\u7684\u884c\u52a8\u53ef\u80fd\u4f1a\u5f71\u54cd\u5230\u4e34\u5e8a\u8bd5\u9a8c\u7684\u542f\u52a8\u3001\u65f6\u95f4\u8868\u548c\u8fdb\u5c55\u4ee5\u53ca\u836f\u7269\u4e0a\u5e02\u5ba1\u6279\uff1b\u767e\u6d4e\u795e\u5dde\u7684\u4e0a\u5e02\u836f\u7269\u53ca\u836f\u7269\u5019\u9009\u7269\uff08\u5982\u80fd\u83b7\u6279\uff09\u83b7\u5f97\u5546\u4e1a\u6210\u529f\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u83b7\u5f97\u548c\u7ef4\u62a4\u5bf9\u5176\u836f\u7269\u548c\u6280\u672f\u7684\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u4f9d\u8d56\u7b2c\u4e09\u65b9\u8fdb\u884c\u836f\u7269\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5176\u4ed6\u670d\u52a1\u7684\u60c5\u51b5\uff1b\u767e\u6d4e\u795e\u5dde\u53d6\u5f97\u76d1\u7ba1\u5ba1\u6279\u548c\u5546\u4e1a\u5316\u533b\u836f\u4ea7\u54c1\u7684\u6709\u9650\u7ecf\u9a8c\uff0c\u53ca\u5176\u83b7\u5f97\u8fdb\u4e00\u6b65\u7684\u8425\u8fd0\u8d44\u91d1\u4ee5\u5b8c\u6210\u5019\u9009\u836f\u7269\u5f00\u53d1\u548c\u5b9e\u73b0\u5e76\u4fdd\u6301\u76c8\u5229\u7684\u80fd\u529b\uff1b\u65b0\u51a0\u80ba\u708e\u5168\u7403\u5927\u6d41\u884c\u5bf9\u767e\u6d4e\u795e\u5dde\u7684\u4e34\u5e8a\u5f00\u53d1\u3001\u76d1\u7ba1\u3001\u5546\u4e1a\u5316\u8fd0\u8425\u53ca\u5176\u4ed6\u4e1a\u52a1\u5e26\u6765\u7684\u5f71\u54cd\uff1b\u767e\u6d4e\u795e\u5dde\u5728\u6700\u8fd1\u5b63\u5ea6\u62a5\u544a10-Q\u8868\u683c\u4e2d\u201c\u98ce\u9669\u56e0\u7d20\u201d\u7ae0\u8282\u91cc\u66f4\u5168\u9762\u8ba8\u8bba\u7684\u5404\u7c7b\u98ce\u9669\uff1b\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u671f\u540e\u5448\u62a5\u4e2d\u5173\u4e8e\u6f5c\u5728\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8ba8\u8bba\u3002\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u4ec5\u53ca\u4e8e\u65b0\u95fb\u7a3f\u53d1\u5e03\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6d4e\u795e\u5dde\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u8be5\u4e9b\u4fe1\u606f\u3002<\/span><\/p>\n<p><b>\u53c2\u8003\u6587\u732e<\/b><\/p>\n<p>1.Tam, et al.A randomized phase 3 trial of zanubrutinib vs ibrutinib in symptomatic Waldenstr&ouml;m macroglobulinemia: the <span class=\"xn-location\">ASPEN<\/span> study.Blood.October 2020.136(18): 2038-2050.<br \/>2.Lymphoma Research Foundation.Available at <a href=\"https:\/\/lymphoma.org\/aboutlymphoma\/nhl\/wm\/.Accessed\" rel=\"nofollow\">https:\/\/lymphoma.org\/aboutlymphoma\/nhl\/wm\/.Accessed<\/a> <span class=\"xn-chron\">December 2020<\/span>.<br \/>3.Chen, et al.Cancer statistics in <span class=\"xn-location\">China<\/span>, 2015 [J].CA: A Cancer Journal for Clinicians, 2016, 66(2):115-132.<br \/>4.Tam, et al.ASPEN: Results of a Phase 3 randomized trial of zanubrutinib versus ibrutinib for patients with Waldenstr&ouml;m macroglobulinemia (WM).DOI: 10.1200\/JCO.2020.38.15_suppl.8007 Journal of Clinical Oncology 38, no. 15_suppl (<span class=\"xn-chron\">May 20, 2020<\/span>) 8007-8007.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u5df2\u4e8e2021\u5e746\u6708\u6279\u51c6\u767e\u60a6\u6cfd\u00ae\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u60a3\u8005 \u6b64\u6b21\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u662f\u57fa\u4e8eASPEN\u8bd5\u9a8c\u7ed3\u679c\uff0c\u6709\u671b\u5c06\u767e\u60a6\u6cfd\u00ae\u7684\u9002\u7528\u8303\u56f4\u62d3\u5c55\u81f3\u4e00\u7ebfWM \u4e2d\u56fd\u5317\u4eac\u548c\u7f8e\u56fd\u9ebb\u7701\u5251\u68652022\u5e741\u670820\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u767e\u6d4e\u795e\u5dde\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff1b\u4e0a\u4ea4\u6240\u4ee3\u7801\uff1a688235\uff09\uff0c\u662f\u4e00\u5bb6\u7acb\u8db3\u79d1\u5b66\u7684\u5168\u7403\u6027\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5728\u4e16\u754c\u8303\u56f4\u5185\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u521b\u65b0\u836f\u7269\uff0c\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u6548\u679c\u548c\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u516c\u53f8\u4eca\u65e5\u5ba3\u5e03\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u5df2\u53d7\u7406\u5176BTK\u6291\u5236\u5242\u767e\u60a6\u6cfd&reg;\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u7528\u4e8e\u6cbb\u7597\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u6210\u4eba\u60a3\u8005\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\uff08sNDA\uff09\u3002 \u767e\u6d4e\u795e\u5dde\u8840\u6db2\u5b66\u9996\u5e2d\u533b\u5b66\u5b98\u9ec4\u851a\u5a1f\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u767e\u60a6\u6cfd&reg;\u7ee7\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u60a3\u8005\u540e\uff0c\u6b64\u6b21sNDA\u7533\u8bf7\u4e5f\u83b7\u5f97NMPA\u53d7\u7406\uff0c\u8fd9\u5bf9\u6211\u4eec\u6765\u8bf4\u662f\u4e00\u4e2a\u597d\u6d88\u606f\u3002\u8fd9\u610f\u5473\u7740\u4e00\u65e6\u53d6\u5f97\u6279\u51c6\uff0c\u66f4\u591a\u4e2d\u56fd\u7684\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u60a3\u8005\u5c06\u6709\u673a\u4f1a\u7528\u4e0a\u8fd9\u6b3e\u836f\u7269\u3002ASPEN\u8bd5\u9a8c\u8868\u660e\uff0c\u767e\u60a6\u6cfd&reg;\u5bf9WM\u60a3\u8005\u800c\u8a00\u662f\u4e00\u9879\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u5f15\u8d77\u623f\u98a4\u7b49\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u7684\u98ce\u9669\u66f4\u4f4e\u3002\u5728ASPEN\u8bd5\u9a8c\u6570\u636e\u7684\u652f\u6301\u4e0b\uff0c\u767e\u60a6\u6cfd&reg;\u5df2\u7ecf\u5728\u7f8e\u56fd\u3001\u52a0\u62ff\u5927\u3001\u6fb3\u5927\u5229\u4e9a\u548c\u6b27\u76df\u83b7\u6279\u7528\u4e8eWM\u60a3\u8005\u7684\u6cbb\u7597\u6211\u4eec\u671f\u5f85\u4e0eCDE\u7ee7\u7eed\u63a2\u8ba8\uff0c\u4e89\u53d6\u5c06\u8fd9\u4e00\u5177\u5907\u2018\u540c\u7c7b\u6700\u4f18\u2019\u6f5c\u529b\u7684\u836f\u7269\u63d0\u4f9b\u7ed9\u66f4\u591a\u4e2d\u56fdWM\u60a3\u8005\u7684\u673a\u4f1a\u3002\u201d&nbsp; \u6b64\u6b21sNDA\u7533\u8bf7\u57fa\u4e8eASPEN\u8bd5\u9a8c\u6570\u636e\uff0c\u8fd9\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT03053400\uff09\uff0c\u5bf9\u6bd4\u4e86\u767e\u60a6\u6cfd&reg;\u4e0e\u4f0a\u5e03\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\uff08R\/R\uff09\u6216\u521d\u6cbb\uff08TN\uff09WM\u60a3\u8005\u7684\u6570\u636e\u3002 \u7ecf\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRC\uff09\u6839\u636e\u7b2c\u516d\u5c4a\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u56fd\u9645\u7814\u8ba8\u4f1a\uff08IWWM-6\uff09\u4fee\u8ba2\u7248\u7f13\u89e3\u6807\u51c6\uff08Treon 2015\uff09\u8bc4\u4f30\uff0c\u767e\u60a6\u6cfd&reg;\u6cbb\u7597\u7ec4\u5728\u603b\u4f53\u610f\u5411\u6027\u6cbb\u7597\uff08ITT\uff09\u4eba\u7fa4\u4e2d\u7684\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u548c\u975e\u5e38\u597d\u7684\u90e8\u5206\u7f13\u89e3\uff08VGPR\uff09\u7387\u7684\u7efc\u5408\u4e3a28%\uff0895%&nbsp;CI\uff1a20\uff0c38\uff09\uff0c\u800c\u4f0a\u5e03\u66ff\u5c3c\u7ec4\u4e3a19%\uff0895%&nbsp;CI\uff1a12\uff0c28\uff09\u3002\u5c3d\u7ba1\u4e24\u7ec4\u6570\u636e\u7684\u5dee\u5f02\u672a\u8fbe\u5230\u7edf\u8ba1\u5b66\u663e\u8457\u6027\uff08p=0.09\uff09\uff0c\u4f46\u767e\u60a6\u6cfd&reg;\u5c55\u73b0\u4e86\u66f4\u9ad8\u7684VGPR\u7387\u6570\u636e\uff0c\u4e14\u7f13\u89e3\u8d28\u91cf\u5448\u73b0\u51fa\u6539\u5584\u8d8b\u52bf\u3002[1] \u5728ASPEN\u8bd5\u9a8c\u4e2d\uff0c\u4e0e\u4f0a\u5e03\u66ff\u5c3c\u76f8\u6bd4\uff0c\u767e\u60a6\u6cfd&reg;\u53d6\u5f97\u4e86\u66f4\u5177\u4f18\u52bf\u7684\u5b89\u5168\u6027\u6570\u636e\uff0c\u7279\u5b9a\u4e0d\u826f\u4e8b\u4ef6\u7684\u53d1\u751f\u7387\u8f83\u66f4\u4f4e\uff0c\u5305\u62ec\u623f\u98a4\/\u623f\u6251\uff082% vs. 15%\uff09\u548c\u5927\u51fa\u8840\uff086% vs. 9%\uff09\u3002\u5728101\u4f8b\u63a5\u53d7\u767e\u60a6\u6cfd&reg;\u6cbb\u7597\u7684WM\u60a3\u8005\u4e2d\uff0c4%\u7684\u60a3\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u800c\u7ec8\u6b62\u6cbb\u7597\uff0c14%\u7684\u60a3\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u964d\u4f4e\u7528\u836f\u5242\u91cf\u3002[4] \u5173\u4e8e\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7 \u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u662f\u4e00\u79cd\u7f55\u89c1\u60f0\u6027\u6dcb\u5df4\u7624\uff0c\u5728\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u60a3\u8005\u4e2d\u5360\u6bd4\u4e0d\u52302%\u3002[1]&nbsp;\u8be5\u75be\u75c5\u901a\u5e38\u5728\u8001\u5e74\u4eba\u4e2d\u591a\u53d1\uff0c\u4e3b\u8981\u5728\u9aa8\u9ad3\u4e2d\u53d1\u73b0\uff0c\u4f46\u4e5f\u53ef\u80fd\u7d2f\u53ca\u6dcb\u5df4\u7ed3\u548c\u813e\u810f\u3002[2]&nbsp;\u5728\u4e2d\u56fd\uff0c\u6bcf\u5e74\u5927\u7ea6\u670988,200\u4f8b\u6dcb\u5df4\u7624\u65b0\u589e\u75c5\u4f8b\uff0c\u5176\u4e2d\u7ea6\u670991%\u4e3aNHL\uff0c\u8fd9\u610f\u5473\u7740\u6211\u56fd\u6bcf\u5e74\u7ea6\u67091000\u4f8bWM\u65b0\u589e\u75c5\u4f8b\u3002[3] \u5173\u4e8e\u767e\u60a6\u6cfd&reg;\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09 \u767e\u60a6\u6cfd&reg;\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u662f\u4e00\u6b3e\u7531\u767e\u6d4e\u795e\u5dde\u79d1\u5b66\u5bb6\u81ea\u4e3b\u7814\u53d1\u7684\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u76ee\u524d\u6b63\u5728\u5168\u7403\u8fdb\u884c\u5e7f\u6cdb\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9879\u76ee\uff0c\u4f5c\u4e3a\u5355\u836f\u548c\u4e0e\u5176\u4ed6\u7597\u6cd5\u8054\u5408\u7528\u836f\u6cbb\u7597\u591a\u79cdB\u7ec6\u80de\u6076\u6027\u80bf\u7624\u3002\u7531\u4e8e\u65b0\u7684BTK\u4f1a\u5728\u4eba\u4f53\u5185\u4e0d\u65ad\u5408\u6210\uff0c\u767e\u60a6\u6cfd&reg;\u7684\u8bbe\u8ba1\u901a\u8fc7\u4f18\u5316\u751f\u7269\u5229\u7528\u5ea6\u3001\u534a\u8870\u671f\u548c\u9009\u62e9\u6027\uff0c\u5b9e\u73b0\u5bf9BTK\u86cb\u767d\u5b8c\u5168\u3001\u6301\u7eed\u7684\u6291\u5236\u3002\u51ed\u501f\u4e0e\u5176\u4ed6\u83b7\u6279BTK\u6291\u5236\u5242\u5b58\u5728\u5dee\u5f02\u5316\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff0c\u767e\u60a6\u6cfd&reg;\u80fd\u5728\u591a\u4e2a\u75be\u75c5\u76f8\u5173\u7ec4\u7ec7\u4e2d\u6291\u5236\u6076\u6027B\u7ec6\u80de\u589e\u6b96\u3002 \u767e\u60a6\u6cfd&reg;\u5df2\u5728\u4ee5\u4e0b\u5730\u533a\u4e2d\u83b7\u6279\u5982\u4e0b\u9002\u5e94\u75c7\uff1a 2019\u5e7411\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005* 2020\u5e746\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684MCL\u60a3\u8005** 2020\u5e746\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74\u6162\u6027\u6dcb\u5df4\u7ec6\u80de&nbsp;\u767d\u8840\u75c5\uff08CLL\uff09\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09\u60a3\u8005** 2021\u5e742\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u963f\u62c9\u4f2f\u8054\u5408\u914b\u957f\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027MCL\u60a3\u8005 2021\u5e743\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u52a0\u62ff\u5927\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u6210\u5e74\u60a3\u8005 2021\u5e746\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684WM\u6210\u5e74\u60a3\u8005** 2021\u5e747\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u52a0\u62ff\u5927\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74MCL\u60a3\u8005** 2021\u5e747\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u667a\u5229\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74MCL\u60a3\u8005** 2021\u5e748\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u5df4\u897f\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684MCL\u6210\u5e74\u60a3\u8005 2021\u5e748\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u6210\u5e74WM\u60a3\u8005&nbsp; 2021\u5e749\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u9879\u6297CD20\u7597\u6cd5\u7684\u6210\u5e74\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff08MZL\uff09\u60a3\u8005* 2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u65b0\u52a0\u5761\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684MCL\u6210\u5e74\u60a3\u8005&nbsp; 2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u4ee5\u8272\u5217\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74MCL\u60a3\u8005 2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u6fb3\u5927\u5229\u4e9a\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74WM\u60a3\u8005\u6216\u4f5c\u4e3a\u4e0d\u9002\u5408\u5316\u5b66\u514d\u75ab\u7597\u6cd5WM\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848&nbsp; 2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u6fb3\u5927\u5229\u4e9a\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u6cbb\u7597\u7684MCL\u6210\u5e74\u60a3\u8005\uff0c 2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u4fc4\u7f57\u65af\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684MCL\u6210\u5e74\u60a3\u8005&nbsp; 2021\u5e7411\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u6c99\u7279\u963f\u62c9\u4f2f\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\uff1b 2021\u5e7411\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u6b27\u76df\u3001\u51b0\u5c9b\u3001\u5217\u652f\u6566\u58eb\u767b\u548c\u632a\u5a01\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u7597\u6cd5\u7684\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u6210\u4eba\u60a3\u8005\uff0c\u6216\u4f5c\u4e3a\u4e00\u7ebf\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u4e0d\u9002\u5408\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u7684\u60a3\u8005\uff1b 2021\u5e7412\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u82f1\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u7597\u6cd5\u7684\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u6210\u4eba\u60a3\u8005\uff0c\u6216\u4f5c\u4e3a\u4e00\u7ebf\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u4e0d\u9002\u5408\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u7684\u60a3\u8005\uff1b 2021\u5e7412\u6708\uff0c\u767e\u60a6\u6cfd&reg;\u5728\u5384\u74dc\u591a\u5c14\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u7597\u6cd5\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u3002 \u8fc4\u4eca\u4e3a\u6b62\uff0c\u5df2\u9012\u4ea4\u8d85\u8fc730\u4e2a\u9488\u5bf9\u591a\u9879\u9002\u5e94\u75c7\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u8986\u76d6\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u6b27\u76df\u548c\u5176\u4ed620\u591a\u4e2a\u56fd\u5bb6\u6216\u5730\u533a\u3002 *\u8be5\u9879\u9002\u5e94\u75c7\u57fa\u4e8e\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u83b7\u5f97\u52a0\u901f\u6279\u51c6\u3002\u9488\u5bf9\u8be5\u9002\u5e94\u75c7\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u9a8c\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u4e34\u5e8a\u83b7\u76ca\u7684\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002 **\u8be5\u9879\u9002\u5e94\u75c7\u83b7\u9644\u6761\u4ef6\u6279\u51c6\u3002\u9488\u5bf9\u8be5\u9002\u5e94\u75c7\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u6b63\u5728\u5f00\u5c55\u7684\u786e\u8bc1\u6027\u968f\u673a\u3001\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3002 \u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66 \u767e\u6d4e\u795e\u5dde\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u6216\u4e0e\u5fd7\u540c\u9053\u5408\u7684\u5408\u4f5c\u4f19\u4f34\u643a\u624b\uff0c\u4e0d\u65ad\u63a8\u52a8\u540c\u7c7b\u6700\u4f73\u6216\u540c\u7c7b\u7b2c\u4e00\u7684\u4e34\u5e8a\u5019\u9009\u836f\u7269\u7814\u53d1\uff0c\u81f4\u529b\u4e8e\u4e3a\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u6709\u5f71\u54cd\u529b\u3001\u53ef\u53ca\u4e14\u53ef\u8d1f\u62c5\u7684\u836f\u7269\u3002\u516c\u53f8\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u548c\u5f00\u53d1\u56e2\u961f\u5df2\u6709\u7ea62300\u4eba\uff0c\u56e2\u961f\u89c4\u6a21\u8fd8\u5728\u4e0d\u65ad\u6269\u5927\u3002\u8fd9\u652f\u56e2\u961f\u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u56f4\u652f\u6301\u5f00\u5c5590\u591a\u9879\u4e34\u5e8a\u7814\u7a76\uff0c\u5df2\u62db\u52df\u60a3\u8005\u548c\u5065\u5eb7\u53d7\u8bd5\u8005\u8d85\u8fc713000\u4eba\u3002\u767e\u6d4e\u795e\u5dde\u81ea\u6709\u7684\u4e34\u5e8a\u5f00\u53d1\u56e2\u961f\u89c4\u5212\u5e76\u4e3b\u5bfc\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u7684\u7814\u53d1\u548c\u6269\u5145\uff0c\u4e3a\u8986\u76d6\u5168\u740340\u591a\u4e2a\u56fd\u5bb6\/\u5730\u533a\u7684\u4e34\u5e8a\u8bd5\u9a8c\u63d0\u4f9b\u652f\u6301\u548c\u6307\u5bfc\u3002\u76ee\u524d\uff0c\u767e\u6d4e\u795e\u5dde\u81ea\u4e3b\u7814\u53d1\u7684\u4e09\u6b3e\u836f\u7269\u5df2\u83b7\u6279\u4e0a\u5e02\uff1a\u767e\u60a6\u6cfd&reg;\uff08BTK\u6291\u5236\u5242\uff0c\u5df2\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u52a0\u62ff\u5927\u53ca\u5176\u4ed6\u56fd\u9645\u5e02\u573a\u83b7\u6279\u4e0a\u5e02\uff09\u3001\u767e\u6cfd\u5b89&reg;\uff08\u53ef\u6709\u6548\u907f\u514dFc-\u03b3\u53d7\u4f53\u7ed3\u5408\u7684\u6297PD-1\u6297\u4f53\uff0c\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff09\u53ca\u767e\u6c47\u6cfd&reg;\uff08\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff09\u3002\u767e\u6d4e\u795e\u5dde\u62e5\u6709\u4e00\u652f\u8ffd\u6c42\u9ad8\u54c1\u8d28\u4e0e\u521b\u65b0\u3001\u7acb\u8db3\u79d1\u5b66\u4e0e\u533b\u5b66\u7684\u56e2\u961f\uff0c\u5e76\u5728\u4e2d\u56fd\u5efa\u7acb\u4e86\u9886\u5148\u5730\u4f4d\uff0c\u6253\u9020\u4e86\u4e00\u652f\u89c4\u6a21\u5e9e\u5927\u3001\u805a\u7126\u4e8e\u80bf\u7624\u5b66\u7684\u5546\u4e1a\u56e2\u961f\u3002&nbsp; \u540c\u65f6\uff0c\u767e\u6d4e\u795e\u5dde\u8fd8\u4e0e\u5176\u4ed6\u521b\u65b0\u516c\u53f8\u5408\u4f5c\uff0c\u5171\u540c\u643a\u624b\u63a8\u8fdb\u521b\u65b0\u7597\u6cd5\u7684\u7814\u53d1\uff0c\u4ee5\u6ee1\u8db3\u5168\u7403\u5065\u5eb7\u9700\u6c42\u3002\u5728\u4e2d\u56fd\uff0c\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u9500\u552e\u591a\u6b3e\u7531\u5b89\u8fdb\u548c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u6388\u6743\u7684\u80bf\u7624\u836f\u7269\u3002\u516c\u53f8\u4e5f\u901a\u8fc7\u4e0e\u5305\u62ec\u5b89\u8fdb\u3001\u767e\u5965\u6cf0\u3001EUSA Pharma\u3001Mirati Therapeutics\u3001Seagen \u4ee5\u53ca&nbsp;Zymeworks \u5728\u5185\u7684\u591a\u5bb6\u516c\u53f8\u5408\u4f5c\uff0c\u66f4\u5927\u7a0b\u5ea6\u6ee1\u8db3\u5f53\u524d\u5168\u7403\u8303\u56f4\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002\u767e\u6d4e\u795e\u5dde\u8fd8\u4e0e\u8bfa\u534e\u516c\u53f8\u8fbe\u6210\u5408\u4f5c\uff0c\u6388\u6743\u8bfa\u534e\u5728\u5317\u7f8e\u3001\u6b27\u6d32\u548c\u65e5\u672c\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u767e\u6cfd\u5b89&reg;\u3002 \u5173\u4e8e\u767e\u6d4e\u795e\u5dde \u767e\u6d4e\u795e\u5dde\u662f\u4e00\u5bb6\u7acb\u8db3\u79d1\u5b66\u7684\u5168\u7403\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u521b\u65b0\u3001\u53ef\u8d1f\u62c5\u7684\u836f\u7269\uff0c\u4ee5\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u6548\u679c\u548c\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u76ee\u524d\u516c\u53f8\u5e7f\u6cdb\u7684\u836f\u7269\u7ec4\u5408\u5305\u62ec40\u591a\u6b3e\u4e34\u5e8a\u5019\u9009\u836f\u7269\u3002\u516c\u53f8\u901a\u8fc7\u52a0\u5f3a\u81ea\u4e3b\u7814\u53d1\u80fd\u529b\u548c\u5408\u4f5c\uff0c\u52a0\u901f\u63a8\u8fdb\u591a\u5143\u3001\u521b\u65b0\u7684\u836f\u7269\u7ba1\u7ebf\u5f00\u53d1\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u57282030\u5e74\u524d\u4e3a\u5168\u740320\u591a\u4ebf\u4eba\u5168\u9762\u6539\u5584\u836f\u7269\u53ef\u53ca\u6027\u3002\u767e\u6d4e\u795e\u5dde\u5728\u5168\u7403\u4e94\u5927\u6d32\u6253\u9020\u4e86\u4e00\u652f\u8d85\u8fc78000\u4eba\u7684\u56e2\u961f\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.beigene.com.cn\u3002 \u524d\u77bb\u6027\u58f0\u660e \u672c\u65b0\u95fb\u7a3f\u5305\u542b\u6839\u636e\u300a1995\u5e74\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2022012017000060929\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-60929","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/60929","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=60929"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/60929\/revisions"}],"predecessor-version":[{"id":60930,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/60929\/revisions\/60930"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=60929"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=60929"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=60929"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}