{"id":60789,"date":"2022-01-20T19:41:00","date_gmt":"2022-01-20T12:41:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022012019410060789"},"modified":"2022-01-21T18:00:06","modified_gmt":"2022-01-21T10:00:06","slug":"%e8%8b%b1%e9%a3%9e%e5%87%a1%e8%81%94%e5%90%88%e5%8c%96%e7%96%97%e4%b8%80%e7%ba%bf%e6%b2%bb%e7%96%97%e6%99%9a%e6%9c%9f%e8%83%86%e9%81%93%e7%99%8c%e5%8f%af%e4%bd%bf%e6%82%a3%e8%80%85%e7%9a%84%e6%ad%bb","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022012019410060789","title":{"rendered":"\u82f1\u98de\u51e1\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u80c6\u9053\u764c\u53ef\u4f7f\u60a3\u8005\u7684\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e 20%"},"content":{"rendered":"

TOPAZ-1 \u662f\u9996\u4e2a\u663e\u793a\u514d\u75ab\u8054\u5408\u6cbb\u7597\u53ef\u4ee5\u63d0\u5347\u60a3\u8005\u751f\u5b58\u7684 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u8054\u5408\u6cbb\u7597\u5bf9\u6bd4\u5355\u72ec\u5316\u7597\uff0c\u6ca1\u6709\u589e\u52a0\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5bfc\u81f4\u7684\u505c\u836f<\/span><\/p>\n

\u4e0a\u6d772022\u5e741\u670820\u65e5 \/\u7f8e\u901a\u793e\/ — III \u671f\u4e34\u5e8a\u8bd5\u9a8c TOPAZ-1 \u7814\u7a76<\/b>\u7684\u9633\u6027\u7ed3\u679c\u8bc1\u5b9e\uff0c\u963f\u65af\u5229\u5eb7\u516c\u53f8\u7684\u82f1\u98de\u51e1\uff08\u901a\u7528\u540d\uff1a\u5ea6\u4f10\u5229\u5c24\u5355\u6297\uff09<\/b>\u8054\u5408\u6807\u51c6\u5316\u7597\u5bf9\u6bd4\u5355\u72ec\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u80c6\u9053\u764c (<\/b>BTC) <\/b>\u60a3\u8005\uff0c\u663e\u793a\u4e86\u5177\u6709\u663e\u8457\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u603b\u751f\u5b58\u671f (OS) \u4ee5\u53ca\u65e0\u8fdb\u5c55\u751f\u5b58\u671f (PFS) \u83b7\u76ca\u3002<\/p>\n

\u8fd9\u4e9b\u7ed3\u679c\u5c06\u4e8e\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f4 1 \u6708 21 \u65e5\u5728 2022 \u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\u6d88\u5316\u9053\u80bf\u7624\u7814\u8ba8\u4f1a (ASCO GI) \u4e0a\u516c\u5e03\u3002<\/p>\n

BTC \u662f\u4e00\u7ec4\u7f55\u89c1\u7684\u6e90\u53d1\u4e8e\u80c6\u7ba1\u548c\u80c6\u56ca\u4e2d\u4e14\u8fdb\u5c55\u8fc5\u901f\u7684\u80bf\u7624[1],[2]<\/sup>\u3002\u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u65e5\u672c\uff0c\u6bcf\u5e74\u7ea6\u6709 50,000 \u4eba\u4ee5\u53ca\u5168\u7403\u7ea6\u6709 210,000 \u4eba\u88ab\u8bca\u65ad\u51fa\u60a3\u6709 BTC[3]-[5]<\/sup>\u3002\u8fd9\u4e9b\u60a3\u8005\u7684\u9884\u540e\u5f88\u5dee\uff0c\u60a3\u8005\u7684\u4e94\u5e74\u751f\u5b58\u7387\u5927\u7ea6\u53ea\u6709 5% \u5230 15% [6] <\/sup>\u3002<\/p>\n

\u533b\u5b66\u535a\u58eb\u3001\u9996\u5c14\u56fd\u7acb\u5927\u5b66\u533b\u9662\u548c\u9996\u5c14\u56fd\u7acb\u5927\u5b66\u533b\u5b66\u9662\u5185\u79d1\u80bf\u7624\u5185\u79d1\u6559\u6388\u3001<\/b>III <\/b>\u671f\u4e34\u5e8a\u8bd5\u9a8c <\/b>TOPAZ-1 \u7814\u7a76<\/b>\u7684\u4e3b\u8981\u7814\u7a76\u8005 <\/b>Do-Youn Oh<\/span> \u6559\u6388<\/b>\u8868\u793a\uff1a\u201c\u665a\u671f\u80c6\u9053\u764c\u7684\u6cbb\u7597\u5341\u4f59\u5e74\u6765\u8fdb\u5c55\u751a\u5fae\uff0c\u800c TOPAZ-1 \u7814\u7a76\u7684\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u6807\u51c6\u6cbb\u7597\u76f8\u6bd4\uff0c<\/b>\u5ea6\u4f10\u5229\u5c24\u5355\u6297<\/b>\u8054\u5408\u5316\u7597\u80fd\u5e26\u6765\u663e\u8457\u7684\u751f\u5b58\u83b7\u76ca\uff0c\u5e76\u663e\u793a\u51fa\u5f3a\u5927\u7684\u5b89\u5168\u6027<\/b>\uff0c\u8fd9\u5bf9\u60a3\u8005\u6765\u8bf4\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u8fdb\u6b65\u3002\u76ee\u524d\u75be\u75c5\u9884\u540e\u6781\u5dee\u7684\u60c5\u51b5\u4e0b\uff0c\u8fd9\u79cd\u6cbb\u7597\u7ec4\u5408\u5c06\u662f\u4e00\u79cd\u8feb\u5207\u9700\u8981\u7684\u3001\u53ef\u80fd\u6539\u53d8\u4e34\u5e8a\u5b9e\u8df5\u7684\u5168\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/p>\n

\u963f\u65af\u5229\u5eb7\u80bf\u7624\u7814\u53d1\u6267\u884c\u526f\u603b\u88c1<\/b> Susan Galbraith<\/b> \u8868\u793a\uff1a\u201cTOPAZ-1 \u7814\u7a76\u7684\u7ed3\u679c\u5237\u65b0\u4e86\u4eba\u4eec\u5bf9\u665a\u671f\u80c6\u9053\u764c\u7684\u6cbb\u7597\u9884\u671f\uff0c\u4e3a\u60a3\u8005\u7684\u957f\u671f\u751f\u5b58\u7684\u53ef\u80fd\u63d0\u4f9b\u4e86\u4ee4\u4eba\u4fe1\u670d\u7684\u8bc1\u636e\u3002\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u63d0\u9ad8\uff0c\u63a5\u53d7\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u5927\u7ea6\u6709\u56db\u5206\u4e4b\u4e00\u5728\u4e24\u5e74\u65f6\u4ecd\u7136\u5b58\u6d3b\uff0c\u8fd9\u4e00\u6bd4\u4f8b\u5728\u63a5\u53d7\u5355\u72ec\u5316\u7597\u7684\u60a3\u8005\u4e2d\u4ec5\u6709\u5341\u5206\u4e4b\u4e00<\/b>\u3002\u8fd9\u5bf9\u665a\u671f\u80c6\u9053\u764c\u60a3\u8005\u6765\u8bf4\u662f\u4e00\u79cd\u6f5c\u5728\u7684\u65b0\u578b\u6807\u51c6\u6cbb\u7597\uff0c\u6211\u4eec\u4f1a\u6301\u7eed\u81f4\u529b\u4e8e\u5728\u6709\u5927\u91cf\u672a\u6ee1\u8db3\u9700\u6c42\u7684\u6d88\u5316\u9053\u80bf\u7624\u6cbb\u7597\u65b9\u9762\u53d6\u5f97\u8fdb\u5c55\u3002\u201d<\/p>\n

\u5728\u9884\u5b9a\u7684\u4e2d\u671f\u5206\u6790\u4e2d\uff0c\u4e0e\u5355\u72ec\u5316\u7597\u76f8\u6bd4\uff0c<\/b>\u5ea6\u4f10\u5229\u5c24\u5355\u6297<\/b>\u8054\u5408\u6807\u51c6\u5316\u7597\u7ec4\u5c06\u60a3\u8005\u7684\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e86<\/b>20%<\/b>\uff08[HR]\uff1a0.80\uff1b95%[CI]\uff0c0.66-0.97\uff1b\u53cc\u4fa7p=0.021\uff09\uff0c\u4e2d\u4f4d <\/b>OS \u4e3a 12.8 \u4e2a\u6708<\/b>\uff0c\u5bf9\u6bd4\u5355\u72ec\u5316\u7597\u7ec4 11.5 \u4e2a\u6708\u3002\u8054\u5408\u5316\u7597\u7ec4\u7ea6 <\/b>25% \u7684\u60a3\u8005\u5728\u4e24\u5e74\u540e\u4ecd\u7136\u5b58\u6d3b<\/b>\uff0c\u800c\u5355\u72ec\u5316\u7597\u7ec4\u7684\u8fd9\u4e00\u6bd4\u4f8b\u4e3a 10%\u3002<\/p>\n

\u7ed3\u679c\u8fd8\u663e\u793a\uff0c\u5ea6\u4f10\u5229\u5c24\u5355\u6297<\/b>\u8054\u5408\u5316\u7597\u4f7f\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e86 <\/b>25%<\/b>\uff08HR\uff0c0.75\uff1b95%CI\uff0c0.64-0.89\uff1b\u53cc\u4fa7p=0.001\uff09\u3002\u8054\u5408\u6cbb\u7597\u7ec4\u7684\u4e2d\u4f4d <\/b>PFS <\/b>\u4e3a <\/b>7.2 <\/b>\u4e2a\u6708<\/b>\uff0c\u800c\u5355\u72ec\u5316\u7597\u7ec4\u7684\u4e2d\u4f4d PFS \u4e3a 5.7 \u4e2a\u6708\u3002\u63a5\u53d7<\/b>\u5ea6\u4f10\u5229\u5c24\u5355\u6297<\/b>\u8054\u5408\u5316\u7597\u6cbb\u7597\u7684\u60a3\u8005\u7684\u5ba2\u89c2\u7f13\u89e3\u7387 (O<\/b>RR) <\/b>\u8fbe <\/b>26.7%<\/b>\uff0c\u800c\u5355\u72ec\u5316\u7597\u7ec4\u7684 ORR \u4e3a 18.7%\u3002<\/p>\n

\u7597\u6548\u6570\u636e\u6c47\u603b<\/b>i<\/sup><\/b>:<\/b><\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n\n

\u5ea6\u4f10\u5229\u5c24\u5355\u6297<\/b>+<\/b>\u5316\u7597<\/b><\/span><\/p>\n

(n=341)<\/b><\/span><\/p>\n<\/td>\n

\n

\u5b89\u6170\u5242<\/b>+<\/b>\u5316\u7597<\/b><\/span><\/p>\n

(n=344)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

OSii,iii<\/sup><\/b><\/span><\/p>\n<\/td>\n

<\/td>\n<\/td>\n<\/tr>\n
\n

\u53d1\u751f\u4e8b\u4ef6\u7684\u60a3\u8005\u767e\u5206\u6bd4<\/span><\/p>\n<\/td>\n

\n

58.1<\/span><\/p>\n<\/td>\n

\n

65.7<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e2d\u4f4d OS  (95% CI) (\u6708)<\/span><\/p>\n<\/td>\n

\n

12.8 (11.1, 14.0)<\/span><\/p>\n<\/td>\n

\n

11.5 (10.1, 12.5)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

HR (95% CI) <\/span><\/p>\n

\u53cc\u4fa7p\u503c<\/span><\/p>\n<\/td>\n

\n

0.80 (0.66, 0.97)<\/span><\/p>\n

0.021<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

18\u4e2a\u6708\u7684OS \u7387 (95% CI) (%)<\/span><\/p>\n<\/td>\n

\n

35.1 (29.1, 41.2)<\/span><\/p>\n<\/td>\n

\n

25.6 (19.9, 31.7)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

24\u4e2a\u6708\u7684 OS \u7387 (95% CI) (%)<\/span><\/p>\n<\/td>\n

\n

24.9 (17.9, 32.5)<\/span><\/p>\n<\/td>\n

\n

10.4 (4.7, 18.8)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

PFSiv,v<\/sup><\/b><\/span><\/p>\n<\/td>\n

<\/td>\n<\/td>\n<\/tr>\n
\n

\u53d1\u751f\u4e8b\u4ef6\u7684\u60a3\u8005\u767e\u5206\u6bd4<\/span><\/p>\n<\/td>\n

\n

80.9<\/span><\/p>\n<\/td>\n

\n

86.3<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e2d\u4f4d PFS  (95% CI) (\u6708)<\/span><\/p>\n<\/td>\n

\n

7.2 (6.7, 7.4)<\/span><\/p>\n<\/td>\n

\n

5.7 (5.6, 6.7)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

HR (95% CI) <\/span><\/p>\n

\u53cc\u4fa7p\u503c<\/span><\/p>\n<\/td>\n

\n

0.75 (0.64, 0.89)<\/span><\/p>\n

0.001<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

ORR <\/b>(%)<\/span><\/p>\n<\/td>\n

\n

26.7<\/span><\/p>\n<\/td>\n

\n

18.7<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

i. \u5206\u6790\u5728 OS \u6570\u636e\u7684 62% \u6210\u719f\u5ea6\u4e0a\u8fdb\u884c
ii. \u7814\u7a76\u8005\u8bc4\u4f30\u7684 OS \u6570\u636e\u622a\u6b62\u65e5\u671f\u4e3a 2021 \u5e74 8 \u6708 11 \u65e5
iii. \u5728 DCO \u65f6\u88ab\u5220\u5931\u7684\u60a3\u8005\u4e2d\u4f4d\u968f\u8bbf\uff1a\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u4e3a 13.7 \u4e2a\u6708\uff08\u8303\u56f4 0.4-27.2\uff09\uff0c\u5355\u72ec\u5316\u7597\u7ec4\u4e3a 12.6 \u4e2a\u6708\uff08\u8303\u56f4 0.7-26.0\uff09
iv. \u7814\u7a76\u8005\u8bc4\u4f30\u7684 PFS \u6570\u636e\u622a\u6b62\u65e5\u671f\u4e3a 2021 \u5e74 8 \u6708 11 \u65e5
v. \u5728 DCO \u65f6\u88ab\u5ba1\u67e5\u7684\u60a3\u8005\u7684\u4e2d\u4f4d\u968f\u8bbf\uff1a\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u52a0\u5316\u7597\u4e3a 9.2 \u4e2a\u6708\uff08\u8303\u56f4 0.0-24.0\uff09\uff0c\u5355\u72ec\u5316\u7597\u7ec4\u4e3a 6.9 \u4e2a\u6708\uff08\u8303\u56f4 0.0-20.4\uff09<\/p>\n

\u4e0e\u5355\u72ec\u5316\u7597\u76f8\u6bd4\uff0c\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u6ca1\u6709\u589e\u52a0\u56e0\u4e0d\u826f\u4e8b\u4ef6 (AEs) \u5bfc\u81f4\u7684\u505c\u836f\u7387\u3002\u60a3\u8005\u51fa\u73b0 3 \u7ea7\u6216 4 \u7ea7\u6cbb\u7597\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\u6570\u636e\u4e3a\uff1a\u8054\u5408\u6cbb\u7597\u7ec4 <\/b>62.7%\uff0c\u5355\u72ec\u5316\u7597\u7ec4 64.9%<\/b>\u3002\u56e0\u6cbb\u7597\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\u800c\u505c\u836f\u7684\u6570\u636e\u4e3a\uff1a\u8054\u5408\u6cbb\u7597\u7ec4 <\/b>8.9%\uff0c\u5355\u72ec\u5316\u7597\u7ec4\u5219\u4e3a 11.4%<\/b>\u3002<\/p>\n

2020 \u5e74 12 \u6708\uff0c\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u5728\u7f8e\u56fd\u83b7\u5f97<\/b>\u7528\u4e8e\u6cbb\u7597<\/b> BTC \u7684<\/b>\u5b64\u513f\u836f\u8ba4\u5b9a\u3002<\/b>2021 \u5e74 10 \u6708\uff0c\u56e0\u6709\u660e\u786e\u8bc1\u636e\u8bc1\u5b9e\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u7684\u7597\u6548\uff0c\u72ec\u7acb\u6570\u636e\u76d1\u6d4b\u59d4\u5458\u4f1a\u5efa\u8bae III \u671f TOPAZ-1 \u4e34\u5e8a\u8bd5\u9a8c\u5728\u4e2d\u671f\u5206\u6790\u65f6\u63ed\u76f2\u3002<\/p>\n

\u53e6\u4e00\u9879\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u5728 III \u671f HIMALAYA \u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u6570\u636e\u4e5f\u5c06\u5728 ASCO \u6d88\u5316\u9053\u80bf\u7624\u7814\u8ba8\u4f1a\u4e0a\u6c47\u62a5\uff0c\u5c55\u73b0\u5176\u5728\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684\u809d\u764c\u4e2d\u7684\u6f5c\u529b\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

TOPAZ-1 \u662f\u9996\u4e2a\u663e\u793a\u514d\u75ab\u8054\u5408\u6cbb\u7597\u53ef\u4ee5\u63d0\u5347\u60a3\u8005\u751f\u5b58\u7684 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u8054\u5408\u6cbb\u7597\u5bf9\u6bd4\u5355\u72ec\u5316\u7597\uff0c\u6ca1\u6709\u589e\u52a0\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5bfc\u81f4\u7684\u505c\u836f \u4e0a\u6d772022\u5e741\u670820\u65e5 \/\u7f8e\u901a\u793e\/ — III \u671f\u4e34\u5e8a\u8bd5\u9a8c TOPAZ-1 \u7814\u7a76\u7684\u9633\u6027\u7ed3\u679c\u8bc1\u5b9e\uff0c\u963f\u65af\u5229\u5eb7\u516c\u53f8\u7684\u82f1\u98de\u51e1\uff08\u901a\u7528\u540d\uff1a\u5ea6\u4f10\u5229\u5c24\u5355\u6297\uff09\u8054\u5408\u6807\u51c6\u5316\u7597\u5bf9\u6bd4\u5355\u72ec\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u80c6\u9053\u764c (BTC) \u60a3\u8005\uff0c\u663e\u793a\u4e86\u5177\u6709\u663e\u8457\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u603b\u751f\u5b58\u671f (OS) \u4ee5\u53ca\u65e0\u8fdb\u5c55\u751f\u5b58\u671f (PFS) \u83b7\u76ca\u3002 \u8fd9\u4e9b\u7ed3\u679c\u5c06\u4e8e\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f4 1 \u6708 21 \u65e5\u5728 2022 \u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\u6d88\u5316\u9053\u80bf\u7624\u7814\u8ba8\u4f1a (ASCO GI) \u4e0a\u516c\u5e03\u3002 BTC \u662f\u4e00\u7ec4\u7f55\u89c1\u7684\u6e90\u53d1\u4e8e\u80c6\u7ba1\u548c\u80c6\u56ca\u4e2d\u4e14\u8fdb\u5c55\u8fc5\u901f\u7684\u80bf\u7624[1],[2]\u3002\u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u65e5\u672c\uff0c\u6bcf\u5e74\u7ea6\u6709 50,000 \u4eba\u4ee5\u53ca\u5168\u7403\u7ea6\u6709 210,000 \u4eba\u88ab\u8bca\u65ad\u51fa\u60a3\u6709 BTC[3]-[5]\u3002\u8fd9\u4e9b\u60a3\u8005\u7684\u9884\u540e\u5f88\u5dee\uff0c\u60a3\u8005\u7684\u4e94\u5e74\u751f\u5b58\u7387\u5927\u7ea6\u53ea\u6709 5% \u5230 15% [6] \u3002 \u533b\u5b66\u535a\u58eb\u3001\u9996\u5c14\u56fd\u7acb\u5927\u5b66\u533b\u9662\u548c\u9996\u5c14\u56fd\u7acb\u5927\u5b66\u533b\u5b66\u9662\u5185\u79d1\u80bf\u7624\u5185\u79d1\u6559\u6388\u3001III \u671f\u4e34\u5e8a\u8bd5\u9a8c TOPAZ-1 \u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005 Do-Youn Oh \u6559\u6388\u8868\u793a\uff1a\u201c\u665a\u671f\u80c6\u9053\u764c\u7684\u6cbb\u7597\u5341\u4f59\u5e74\u6765\u8fdb\u5c55\u751a\u5fae\uff0c\u800c TOPAZ-1 \u7814\u7a76\u7684\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u6807\u51c6\u6cbb\u7597\u76f8\u6bd4\uff0c\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u80fd\u5e26\u6765\u663e\u8457\u7684\u751f\u5b58\u83b7\u76ca\uff0c\u5e76\u663e\u793a\u51fa\u5f3a\u5927\u7684\u5b89\u5168\u6027\uff0c\u8fd9\u5bf9\u60a3\u8005\u6765\u8bf4\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u8fdb\u6b65\u3002\u76ee\u524d\u75be\u75c5\u9884\u540e\u6781\u5dee\u7684\u60c5\u51b5\u4e0b\uff0c\u8fd9\u79cd\u6cbb\u7597\u7ec4\u5408\u5c06\u662f\u4e00\u79cd\u8feb\u5207\u9700\u8981\u7684\u3001\u53ef\u80fd\u6539\u53d8\u4e34\u5e8a\u5b9e\u8df5\u7684\u5168\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d \u963f\u65af\u5229\u5eb7\u80bf\u7624\u7814\u53d1\u6267\u884c\u526f\u603b\u88c1 Susan Galbraith \u8868\u793a\uff1a\u201cTOPAZ-1 \u7814\u7a76\u7684\u7ed3\u679c\u5237\u65b0\u4e86\u4eba\u4eec\u5bf9\u665a\u671f\u80c6\u9053\u764c\u7684\u6cbb\u7597\u9884\u671f\uff0c\u4e3a\u60a3\u8005\u7684\u957f\u671f\u751f\u5b58\u7684\u53ef\u80fd\u63d0\u4f9b\u4e86\u4ee4\u4eba\u4fe1\u670d\u7684\u8bc1\u636e\u3002\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u63d0\u9ad8\uff0c\u63a5\u53d7\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u5927\u7ea6\u6709\u56db\u5206\u4e4b\u4e00\u5728\u4e24\u5e74\u65f6\u4ecd\u7136\u5b58\u6d3b\uff0c\u8fd9\u4e00\u6bd4\u4f8b\u5728\u63a5\u53d7\u5355\u72ec\u5316\u7597\u7684\u60a3\u8005\u4e2d\u4ec5\u6709\u5341\u5206\u4e4b\u4e00\u3002\u8fd9\u5bf9\u665a\u671f\u80c6\u9053\u764c\u60a3\u8005\u6765\u8bf4\u662f\u4e00\u79cd\u6f5c\u5728\u7684\u65b0\u578b\u6807\u51c6\u6cbb\u7597\uff0c\u6211\u4eec\u4f1a\u6301\u7eed\u81f4\u529b\u4e8e\u5728\u6709\u5927\u91cf\u672a\u6ee1\u8db3\u9700\u6c42\u7684\u6d88\u5316\u9053\u80bf\u7624\u6cbb\u7597\u65b9\u9762\u53d6\u5f97\u8fdb\u5c55\u3002\u201d \u5728\u9884\u5b9a\u7684\u4e2d\u671f\u5206\u6790\u4e2d\uff0c\u4e0e\u5355\u72ec\u5316\u7597\u76f8\u6bd4\uff0c\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u8054\u5408\u6807\u51c6\u5316\u7597\u7ec4\u5c06\u60a3\u8005\u7684\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8620%\uff08[HR]\uff1a0.80\uff1b95%[CI]\uff0c0.66-0.97\uff1b\u53cc\u4fa7p=0.021\uff09\uff0c\u4e2d\u4f4d OS \u4e3a 12.8 \u4e2a\u6708\uff0c\u5bf9\u6bd4\u5355\u72ec\u5316\u7597\u7ec4… Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-60789","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/60789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=60789"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/60789\/revisions"}],"predecessor-version":[{"id":60790,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/60789\/revisions\/60790"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=60789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=60789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=60789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}