{"id":60352,"date":"2022-01-18T14:55:00","date_gmt":"2022-01-18T07:55:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022011814550060352"},"modified":"2022-01-18T18:06:14","modified_gmt":"2022-01-18T10:06:14","slug":"%e5%8d%ab%e6%9d%90%e4%b8%8eroivant%e7%ad%be%e7%bd%b2%e8%af%95%e9%aa%8c%e6%80%a7%e6%8a%97%e7%99%8c%e8%8d%afh3b-8800%e7%9a%84%e7%8b%ac%e5%ae%b6%e8%ae%b8%e5%8f%af%e5%8d%8f%e8%ae%ae","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022011814550060352","title":{"rendered":"\u536b\u6750\u4e0eROIVANT\u7b7e\u7f72\u8bd5\u9a8c\u6027\u6297\u764c\u836fH3B-8800\u7684\u72ec\u5bb6\u8bb8\u53ef\u534f\u8bae"},"content":{"rendered":"<p><p>\u4e1c\u4eac2022\u5e741\u670818\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1a\u5185\u85e4\u6674\u592b\uff0c\u4e0b\u6587\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u536b\u6750\u5df2\u4e0eRoivant Sciences Ltd.\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aROIV\uff0c\u603b\u90e8\uff1a\u82f1\u56fd\u4f26\u6566\uff0c\u4e0b\u6587\u7b80\u79f0\u201cRoivant\u201d\uff09\u7684\u4e00\u5bb6\u5b50\u516c\u53f8\u7b7e\u8ba2\u8bb8\u53ef\u534f\u8bae\uff0c\u72ec\u5bb6\u6388\u4e88Roivant\u8bd5\u9a8c\u6027\u6297\u764c\u836fH3B-8800\u7684\u5168\u7403\u7814\u7a76\u3001\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u6743\u3002H3B-8800\uff08Roivant\u5f00\u53d1\u4ee3\u7801\uff1aRVT-2001\uff09\u662f\u4e00\u79cd\u526a\u63a5\u8c03\u8282\u5242\u5316\u5408\u7269\uff0c\u7531\u536b\u6750\u7684\u7f8e\u56fd\u7814\u53d1\u5b50\u516c\u53f8H3 Biomedicine Inc.\u53d1\u73b0\uff0c\u76ee\u524d\u6b63\u5728\u4f5c\u4e3a\u8bd5\u9a8c\u6027\u6297\u764c\u836f\u8fdb\u884c\u5f00\u53d1\u3002<\/p>\n<p>H3B-8800\u662f\u4e00\u79cd\u53e3\u670d\u53ef\u5229\u7528\u7684\u526a\u63a5\u56e0\u5b503B\u4e9a\u57fa1\uff08SF3B1\uff09\u7684\u5c0f\u5206\u5b50\u8c03\u8282\u5242\uff0c\u7531H3 Biomedicine Inc.\u53d1\u73b0\u3002\u5728\u57fa\u4e8e\u9057\u4f20\u5bc6\u7801\u7684\u86cb\u767d\u8d28\u5408\u6210\u8fc7\u7a0b\u4e2d\uff0c\u526a\u63a5\u53ef\u53bb\u9664\u86cb\u767d\u8d28\u5408\u6210\u4e0d\u9700\u8981\u7684\u4fe1\u4f7f\u524d\u4f53RNA\uff08mRNA\uff09\u78b1\u57fa\u5e8f\u5217\u7684\u5185\u542b\u5b50\u3002\u5728\u591a\u79cd\u6076\u6027\u8840\u6db2\u75c5\u548c\u5b9e\u4f53\u7624\u4e2d\u5747\u53ef\u89c2\u5bdf\u5230\u7f16\u7801\u526a\u63a5\u56e0\u5b50\u7684\u57fa\u56e0\u7a81\u53d8\u3002<i>SF3B1<\/i>\u662f\u7279\u522b\u5e38\u89c1\u7684\u526a\u63a5\u56e0\u5b50\u57fa\u56e0\u7a81\u53d8\u3002<sup>1,2<\/sup>H3B-8800\u53ef\u7ed3\u5408SF3B1\uff0c\u5e76\u901a\u8fc7\u6d88\u9664\u5bf9\u764c\u75c7\u60a3\u8005mRNA\u526a\u63a5\u7684\u7834\u574f\uff0c\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u8868\u73b0\u51fa\u660e\u663e\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<sup>3<\/sup>\u536b\u6750\u548cH3 Biomedicine\u76ee\u524d\u6b63\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u5bf9\u643a\u5e26SF3B1\u7a81\u53d8\u7684\u9aa8\u9ad3\u5f02\u5e38\u589e\u751f\u7efc\u5408\u5f81\u60a3\u8005\u5f00\u5c55\u4e00\u9879H3B-8800\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p>\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u536b\u6750\u5c06\u83b7\u5f97H3B-8800\u7684\u5408\u540c\u9884\u4ed8\u6b3e\u3001\u5f00\u53d1\u548c\u6ce8\u518c\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u4e0a\u5e02\u540e\u8fd8\u5c06\u6839\u636eH3B-8800\u7684\u9500\u552e\u6536\u5165\uff0c\u83b7\u5f97\u7279\u5b9a\u6bd4\u4f8b\u7684\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/p>\n<p>Roivant\u662f\u4e00\u4e2a\u5177\u6709\u72ec\u7279\u5546\u4e1a\u6a21\u5f0f\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002Roivant\u5efa\u7acb\u5e76\u53d1\u8d77\u4e86\u591a\u5bb6\u5b50\u516c\u53f8\uff0c\u5408\u79f0\u4e3a\u201cVants\u201d\uff0c\u5728\u4e0d\u540c\u7684\u6cbb\u7597\u9886\u57df\u8fdb\u884c\u9ad8\u6548\u7684\u4e34\u5e8a\u5f00\u53d1\u5de5\u4f5c\u3002\u536b\u6750\u8ba4\u4e3a\uff0c\u4e0eRoivant\u7b7e\u7f72\u7684\u672c\u8bb8\u53ef\u534f\u8bae\u5c06\u6709\u52a9\u4e8e\u63a8\u52a8H3B-8800\u7684\u4ef7\u503c\u6700\u5927\u5316\u3002\u536b\u6750\u5c06\u7ee7\u7eed\u52a0\u901f\u5176\u57fa\u4e8e\u524d\u6cbf\u764c\u75c7\u7814\u7a76\u7684\u65b0\u836f\u53d1\u73b0\uff0c\u7aed\u529b\u89e3\u51b3\u764c\u75c7\u60a3\u8005\u3001\u60a3\u8005\u5bb6\u5ead\u548c\u533b\u7597\u670d\u52a1\u63d0\u4f9b\u8005\u7684\u5404\u79cd\u9700\u6c42\u5e76\u589e\u52a0\u5176\u83b7\u76ca\u3002<\/p>\n<div>\n<table id=\"convertedTablea2c4\" cellspacing=\"0\" cellpadding=\"0\" border=\"1\" class=\"prntblns\">\n<tbody>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">1 Yoshida, et al. (2011). Frequent pathway mutations of splicing machinery in myelodysplasia. <i>Nature <\/i>478(7367): 64-69. doi: 10.1038\/nature10496. <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">2 Seiler, et al. (2018). Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types. <i>Cell Reports <\/i>23(1): 282-296.e4. doi: 10.1016\/j.celrep.2018.01.088. <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">3 Seiler, et al. (2018). H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers. <i>Nature Medicine <\/i>24(4): 497-504. doi: 10.1038\/nm.4493.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e1c\u4eac2022\u5e741\u670818\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1a\u5185\u85e4\u6674\u592b\uff0c\u4e0b\u6587\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u536b\u6750\u5df2\u4e0eRoivant Sciences Ltd.\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aROIV\uff0c\u603b\u90e8\uff1a\u82f1\u56fd\u4f26\u6566\uff0c\u4e0b\u6587\u7b80\u79f0\u201cRoivant\u201d\uff09\u7684\u4e00\u5bb6\u5b50\u516c\u53f8\u7b7e\u8ba2\u8bb8\u53ef\u534f\u8bae\uff0c\u72ec\u5bb6\u6388\u4e88Roivant\u8bd5\u9a8c\u6027\u6297\u764c\u836fH3B-8800\u7684\u5168\u7403\u7814\u7a76\u3001\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u6743\u3002H3B-8800\uff08Roivant\u5f00\u53d1\u4ee3\u7801\uff1aRVT-2001\uff09\u662f\u4e00\u79cd\u526a\u63a5\u8c03\u8282\u5242\u5316\u5408\u7269\uff0c\u7531\u536b\u6750\u7684\u7f8e\u56fd\u7814\u53d1\u5b50\u516c\u53f8H3 Biomedicine Inc.\u53d1\u73b0\uff0c\u76ee\u524d\u6b63\u5728\u4f5c\u4e3a\u8bd5\u9a8c\u6027\u6297\u764c\u836f\u8fdb\u884c\u5f00\u53d1\u3002 H3B-8800\u662f\u4e00\u79cd\u53e3\u670d\u53ef\u5229\u7528\u7684\u526a\u63a5\u56e0\u5b503B\u4e9a\u57fa1\uff08SF3B1\uff09\u7684\u5c0f\u5206\u5b50\u8c03\u8282\u5242\uff0c\u7531H3 Biomedicine Inc.\u53d1\u73b0\u3002\u5728\u57fa\u4e8e\u9057\u4f20\u5bc6\u7801\u7684\u86cb\u767d\u8d28\u5408\u6210\u8fc7\u7a0b\u4e2d\uff0c\u526a\u63a5\u53ef\u53bb\u9664\u86cb\u767d\u8d28\u5408\u6210\u4e0d\u9700\u8981\u7684\u4fe1\u4f7f\u524d\u4f53RNA\uff08mRNA\uff09\u78b1\u57fa\u5e8f\u5217\u7684\u5185\u542b\u5b50\u3002\u5728\u591a\u79cd\u6076\u6027\u8840\u6db2\u75c5\u548c\u5b9e\u4f53\u7624\u4e2d\u5747\u53ef\u89c2\u5bdf\u5230\u7f16\u7801\u526a\u63a5\u56e0\u5b50\u7684\u57fa\u56e0\u7a81\u53d8\u3002SF3B1\u662f\u7279\u522b\u5e38\u89c1\u7684\u526a\u63a5\u56e0\u5b50\u57fa\u56e0\u7a81\u53d8\u30021,2H3B-8800\u53ef\u7ed3\u5408SF3B1\uff0c\u5e76\u901a\u8fc7\u6d88\u9664\u5bf9\u764c\u75c7\u60a3\u8005mRNA\u526a\u63a5\u7684\u7834\u574f\uff0c\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u8868\u73b0\u51fa\u660e\u663e\u7684\u6297\u80bf\u7624\u6d3b\u6027\u30023\u536b\u6750\u548cH3 Biomedicine\u76ee\u524d\u6b63\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u5bf9\u643a\u5e26SF3B1\u7a81\u53d8\u7684\u9aa8\u9ad3\u5f02\u5e38\u589e\u751f\u7efc\u5408\u5f81\u60a3\u8005\u5f00\u5c55\u4e00\u9879H3B-8800\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002 \u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u536b\u6750\u5c06\u83b7\u5f97H3B-8800\u7684\u5408\u540c\u9884\u4ed8\u6b3e\u3001\u5f00\u53d1\u548c\u6ce8\u518c\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u4e0a\u5e02\u540e\u8fd8\u5c06\u6839\u636eH3B-8800\u7684\u9500\u552e\u6536\u5165\uff0c\u83b7\u5f97\u7279\u5b9a\u6bd4\u4f8b\u7684\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002 Roivant\u662f\u4e00\u4e2a\u5177\u6709\u72ec\u7279\u5546\u4e1a\u6a21\u5f0f\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002Roivant\u5efa\u7acb\u5e76\u53d1\u8d77\u4e86\u591a\u5bb6\u5b50\u516c\u53f8\uff0c\u5408\u79f0\u4e3a\u201cVants\u201d\uff0c\u5728\u4e0d\u540c\u7684\u6cbb\u7597\u9886\u57df\u8fdb\u884c\u9ad8\u6548\u7684\u4e34\u5e8a\u5f00\u53d1\u5de5\u4f5c\u3002\u536b\u6750\u8ba4\u4e3a\uff0c\u4e0eRoivant\u7b7e\u7f72\u7684\u672c\u8bb8\u53ef\u534f\u8bae\u5c06\u6709\u52a9\u4e8e\u63a8\u52a8H3B-8800\u7684\u4ef7\u503c\u6700\u5927\u5316\u3002\u536b\u6750\u5c06\u7ee7\u7eed\u52a0\u901f\u5176\u57fa\u4e8e\u524d\u6cbf\u764c\u75c7\u7814\u7a76\u7684\u65b0\u836f\u53d1\u73b0\uff0c\u7aed\u529b\u89e3\u51b3\u764c\u75c7\u60a3\u8005\u3001\u60a3\u8005\u5bb6\u5ead\u548c\u533b\u7597\u670d\u52a1\u63d0\u4f9b\u8005\u7684\u5404\u79cd\u9700\u6c42\u5e76\u589e\u52a0\u5176\u83b7\u76ca\u3002 1 Yoshida, et al. (2011). Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 478(7367): 64-69. doi: 10.1038\/nature10496. 2 Seiler, et al. (2018). Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types. Cell Reports 23(1):&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2022011814550060352\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-60352","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/60352","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=60352"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/60352\/revisions"}],"predecessor-version":[{"id":60353,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/60352\/revisions\/60353"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=60352"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=60352"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=60352"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}