{"id":59822,"date":"2022-01-12T13:13:00","date_gmt":"2022-01-12T06:13:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022011213130059822"},"modified":"2022-01-12T18:08:15","modified_gmt":"2022-01-12T10:08:15","slug":"%e6%8b%9c%e8%80%b3%e4%b8%8e-mammoth-biosciences-%e5%b0%86%e5%90%88%e4%bd%9c%e5%bc%80%e5%8f%91%e6%96%b0%e5%9e%8b%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e6%8a%80%e6%9c%af","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022011213130059822","title":{"rendered":"\u62dc\u8033\u4e0e Mammoth Biosciences \u5c06\u5408\u4f5c\u5f00\u53d1\u65b0\u578b\u57fa\u56e0\u7f16\u8f91\u6280\u672f"},"content":{"rendered":"<ul type=\"disc\">\n<li><b>\u534f\u8bae\u8fdb\u4e00\u6b65\u5f3a\u5316\u4e86\u62dc\u8033\u65b0\u5efa\u7acb\u7684\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u5e73\u53f0 <\/b><\/li>\n<li><b>\u652f\u6301 Mammoth \u81f4\u529b\u4e8e\u5b9e\u73b0\u65b0\u578b CRISPR \u7cfb\u7edf\u5168\u90e8\u6f5c\u529b\u7684\u613f\u666f <\/b><\/li>\n<li><b>Mammoth \u5c06\u83b7\u5f97 4,000 \u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u8d85\u8fc7 10 \u4ebf\u7f8e\u5143\u7684\u672a\u6765\u6f5c\u5728\u7684\u91cc\u7a0b\u7891\u6b3e\u9879 <br \/><\/b><\/li>\n<\/ul>\n<p><p>\u5fb7\u56fd\u67cf\u6797\u548c\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5e03\u91cc\u65af\u73ed2022\u5e741\u670812\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u62dc\u8033\u96c6\u56e2\u4e0e&nbsp;Mammoth Biosciences \u516c\u53f8\uff08\u7b80\u79f0Mammoth\uff09\u4e8e 2022 \u5e74&nbsp;1 \u6708&nbsp;10 \u65e5\u5ba3\u5e03\u4e00\u9879\u6218\u7565\u5408\u4f5c\u4e0e\u9009\u62e9\u6743\u534f\u8bae\uff0c\u65e8\u5728\u5229\u7528&nbsp;Mammoth \u7684&nbsp;CRISPR \u7cfb\u7edf\u5f00\u53d1\u4f53\u5185\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u3002\u76ee\u524d Mammoth \u516c\u53f8\u6b63\u5728\u5229\u7528\u81ea\u7136\u591a\u6837\u6027\u9a71\u52a8\u4e0b\u4e00\u4ee3 CRISPR \u4ea7\u54c1\u3002<\/p>\n<p>Mammoth \u516c\u53f8\u5f00\u521b\u6027\u7684\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u662f\u4e00\u9879\u5173\u952e\u6280\u672f\uff0c\u540c\u65f6\u4e5f\u662f\u5355\u72ec\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u5b83\u5c06\u6781\u5927\u5730\u589e\u5f3a\u62dc\u8033\u7684\u521b\u65b0\u80fd\u529b\uff0c\u66f4\u5feb\u5730\u5f00\u53d1\u80fd\u4e3a\u60a3\u8005\u5e26\u6765\u663e\u8457\u5f71\u54cd\u7684\u7597\u6cd5\uff0c\u5e76\u8fdb\u4e00\u6b65\u5f3a\u5316\u516c\u53f8\u8fd1\u671f\u5efa\u7acb\u7684\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u5e73\u53f0\u3002\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u4e24\u5bb6\u516c\u53f8\u5373\u5c06\u5f00\u5c55\u7684\u5408\u4f5c\uff0c\u5c06\u4ee5\u809d\u810f\u9776\u5411\u75be\u75c5\u4e3a\u91cd\u70b9\u3002<\/p>\n<p>\u62dc\u8033\u96c6\u56e2\u7ba1\u7406\u59d4\u5458\u4f1a\u6210\u5458\u3001\u62dc\u8033\u5904\u65b9\u836f\u5168\u7403\u603b\u88c1&nbsp;Stefan Oelrich \u8bf4\uff1a\u201cMammoth \u7684\u65b0\u578b&nbsp;CRISPR \u7cfb\u7edf\u4e0e\u516c\u53f8\u73b0\u6709\u7684\u57fa\u56e0\u589e\u5f3a\u53ca\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de&nbsp;(iPSC) \u5e73\u53f0\u76f8\u7ed3\u5408\uff0c\u5c06\u91ca\u653e\u6211\u4eec\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u7b56\u7565\u7684\u5168\u90e8\u6f5c\u529b\u3002\u4e0e&nbsp;Mammoth <span id=\"spanHghlt23da\">\u9876\u5c16<\/span>\u79d1\u7814\u56e2\u961f\u5408\u4f5c\u662f\u4e00\u4e2a\u91cd\u8981\u652f\u67f1\uff0c\u5c06\u652f\u6301\u6211\u4eec\u6539\u5584\u90a3\u4e9b\u8eab\u60a3\u76ee\u524d\u96be\u6cbb\u578b\u75be\u75c5\u60a3\u8005\u7684\u751f\u6d3b\u3002\u201d<\/p>\n<p>Mammoth \u516c\u53f8\u9996\u5e2d\u5546\u52a1\u5b98\u517c\u6cbb\u7597\u6218\u7565\u8d1f\u8d23\u4eba&nbsp;Peter Nell \u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u4e0e\u62dc\u8033\u5408\u4f5c\u3002\u57fa\u4e8e\u6211\u4eec\u65b0\u578b&nbsp;CRISPR \u7cfb\u7edf\u6280\u672f\u98de\u8dc3\uff0c\u8fd9\u9879\u5408\u4f5c\u7ed3\u5408\u4e86\u62dc\u8033\u5728\u836f\u7269\u5f00\u53d1\u9886\u57df\u7684\u4f18\u52bf\u4e13\u957f\u3002\u5728\u53cc\u65b9\u7684\u5171\u540c\u52aa\u529b\u4e0b\uff0c\u6211\u4eec\u5c06\u6709\u53ef\u80fd\u901a\u8fc7\u5f00\u53d1\u57fa\u4e8e&nbsp;CRISPR \u7684\u65b9\u6cd5\u4ee5\u6ee1\u8db3\u4e34\u5e8a\u6240\u9762\u4e34\u7684\u9002\u5f53\u7d27\u8feb\u6027\uff0c\u4f7f\u60a3\u8005\u53d7\u76ca\uff0c\u540c\u65f6\u786e\u4fdd\u5b66\u672f\u7684\u5353\u8d8a\u6027\u4e0e\u5b89\u5168\u6027\u3002\u201d<\/p>\n<p>\u7ec6\u80de\u548c\u57fa\u56e0\u7597\u6cd5\u662f\u836f\u7269\u5f00\u53d1\u9886\u57df\u53d1\u5c55\u7684\u4e0b\u4e00\u9636\u6bb5\u3002\u901a\u8fc7\u89e3\u51b3\u75be\u75c5\u7684\u6839\u672c\u6210\u56e0\uff0c\u8fd9\u4e9b\u65b0\u578b\u7597\u6cd5\u5177\u6709\u901a\u8fc7\u4e00\u6b21\u6027\u6cbb\u7597\u6c38\u4e45\u9006\u8f6c\u75be\u75c5\u7684\u6f5c\u529b\u3002\u5f53\u5728\u6d3b\u4f53\u5916\uff08\u4f53\u5916\uff09\u4f7f\u7528\u65f6\uff0c\u57fa\u56e0\u7f16\u8f91\u662f\u7ec6\u80de\u7597\u6cd5\u7684\u5173\u952e\u63a8\u52a8\u529b\uff0c\u5f53\u5728\u6d3b\u4f53\u5185\uff08\u4f53\u5185\uff09\u4f7f\u7528\u65f6\uff0c\u53ef\u4ee5\u9488\u5bf9\u5177\u6709\u9ad8\u5ea6\u672a\u6ee1\u8db3\u533b\u7597\u9700\u6c42\u7684\u591a\u79cd\u9057\u4f20\u75be\u75c5\u5b9e\u73b0\u9776\u5411\u6cbb\u7597\u3002<\/p>\n<p>Mammoth \u516c\u53f8\u5305\u62ec&nbsp;Cas14 \u548c&nbsp;Cas<span id=\"spanHghlt7048\">\u0278<\/span> \u5728\u5185\u7684\u8d85\u5c0f\u578b&nbsp;Cas \u9176\u4e13\u6709\u5de5\u5177\u5305\uff0c\u5141\u8bb8\u5c06\u6269\u5c55\u7684\u9ad8\u4fdd\u771f\u57fa\u56e0\u7f16\u8f91\u4e0e\u9776\u5411\u7cfb\u7edf\u9012\u9001\u76f8\u7ed3\u5408\u3002\u6839\u636e\u534f\u8bae\uff0c\u62dc\u8033\u6709\u6743\u4f7f\u7528\u8fd9\u4e00\u65b0\u578b\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u3002\u57fa\u4e8e\u8fd9\u4e9b\u65b0\u578b&nbsp;CRISPR \u7cfb\u7edf\u7684\u8d85\u7d27\u51d1\u5c3a\u5bf8\uff0c\u8be5\u6280\u672f\u5177\u6709\u4f18\u8d8a\u7684\u4f53\u5185\u5e94\u7528\u6f5c\u529b\u3002<\/p>\n<p>\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0cMammoth \u516c\u53f8\u5c06\u83b7\u5f97&nbsp;4,000 \u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\uff0c\u5e76\u6709\u8d44\u683c\u83b7\u5f97\u76ee\u6807\u671f\u6743\u884c\u6743\u8d39\u7528\u4ee5\u53ca\u8d85\u8fc7&nbsp;10 \u4ebf\u7f8e\u5143\u7684\u672a\u6765\u6f5c\u5728\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u8fd9\u4e9b\u4ed8\u6b3e\u57fa\u4e8e\u6210\u529f\u5b8c\u6210\u7279\u5b9a\u7814\u7a76\u3001\u5f00\u53d1\u4ee5\u53ca\u5546\u4e1a\u7b49\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff0c\u6d89\u53ca\u4e94\u4e2a\u9884\u5148\u9009\u62e9\u7684\u4f53\u5185\u9002\u5e94\u75c7\uff0c\u5176\u4e2d\u9996\u5148\u5173\u6ce8\u809d\u810f\u9776\u5411\u75be\u75c5\u3002\u6b64\u5916\uff0c\u62dc\u8033\u5c06\u652f\u4ed8\u7814\u7a76\u7ecf\u8d39\u4ee5\u53ca\u5206\u5c42\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\uff0c\u6700\u9ad8\u53ef\u8fbe\u51c0\u9500\u552e\u989d\u7684\u4e24\u4f4d\u6570\u767e\u5206\u6bd4\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u4e24\u5bb6\u516c\u53f8\u8fd8\u6b63\u5728\u975e\u6392\u4ed6\u6027\u57fa\u7840\u4e0a\u63a2\u7d22\u4f53\u5916\u9879\u76ee\u76f8\u5173\u5de5\u4f5c\u3002<\/p>\n<p><b>\u5173\u4e8e\u62dc\u8033<\/b><\/p>\n<p>\u62dc\u8033\u4f5c\u4e3a\u4e00\u5bb6\u8de8\u56fd\u4f01\u4e1a\uff0c\u5728\u751f\u547d\u79d1\u5b66\u9886\u57df\u7684\u5065\u5eb7\u4e0e\u519c\u4e1a\u65b9\u9762\u5177\u6709\u6838\u5fc3\u7ade\u4e89\u529b\u3002\u516c\u53f8\u81f4\u529b\u4e8e\u901a\u8fc7\u4ea7\u54c1\u548c\u670d\u52a1\uff0c\u5e2e\u52a9\u4eba\u4eec\u514b\u670d\u5168\u7403\u4eba\u53e3\u4e0d\u65ad\u589e\u957f\u548c\u8001\u9f84\u5316\u5e26\u6765\u7684\u91cd\u5927\u6311\u6218\uff0c\u9020\u798f\u4eba\u7c7b\u548c\u5730\u7403\u7e41\u8363\u53d1\u5c55\u3002\u62dc\u8033\u81f4\u529b\u4e8e\u63a8\u52a8\u53ef\u6301\u7eed\u53d1\u5c55\u5e76\u5bf9\u4e1a\u52a1\u4ea7\u751f\u79ef\u6781\u5f71\u54cd\u3002\u540c\u65f6\uff0c\u96c6\u56e2\u8fd8\u901a\u8fc7\u79d1\u6280\u521b\u65b0\u548c\u4e1a\u52a1\u589e\u957f\u6765\u63d0\u5347\u76c8\u5229\u80fd\u529b\u5e76\u521b\u9020\u4ef7\u503c\u3002\u5728\u5168\u7403\uff0c\u62dc\u8033\u54c1\u724c\u4ee3\u8868\u7740\u53ef\u4fe1\u3001\u53ef\u9760\u53ca\u4f18\u8d28\u3002\u5728 2020 \u8d22\u5e74\uff0c\u62dc\u8033\u7684\u5458\u5de5\u4eba\u6570\u7ea6\u4e3a 100,000 \u540d\uff0c\u9500\u552e\u989d\u4e3a 414 \u4ebf\u6b27\u5143\u3002\u4e0d\u8ba1\u7279\u6b8a\u9879\u76ee\u7684\u7814\u7a76\u5f00\u53d1\u6295\u5165\u4e3a 49 \u4ebf\u6b27\u5143\u3002\u66f4\u591a\u4fe1\u606f\u8bf7\u89c1 <a target=\"_blank\" href=\"http:\/\/www.bayer.com\/\" rel=\"nofollow noopener\">www.bayer.com<\/a>\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>&nbsp;Mammoth Biosciences <\/b><\/p>\n<p>Mammoth \u516c\u53f8\u6b63\u5728\u5229\u7528\u751f\u547d\u7684\u591a\u6837\u6027\u9a71\u52a8\u4e0b\u4e00\u4ee3&nbsp;CRISPR \u4ea7\u54c1\u3002\u901a\u8fc7\u65b0\u578b&nbsp;CRISPR \u7cfb\u7edf\u7684\u53d1\u73b0\u4e0e\u5de5\u7a0b\u5316\uff0c\u8be5\u516c\u53f8\u6b63\u5145\u5206\u53d1\u6325\u5176\u5e73\u53f0\u7684\u6f5c\u529b\u6765\u8bfb\u53d6\u548c\u5199\u5165\u751f\u547d\u4ee3\u7801\u3002&nbsp;Mammoth \u65e8\u5728\u5229\u7528\u4e00\u6d41\u7684\u4f53\u5185\u548c\u4f53\u5916\u7597\u6cd5\u5f00\u53d1\u6c38\u4e45\u6027\u57fa\u56e0\u6cbb\u6108\u7597\u6cd5\uff0c\u5e76\u901a\u8fc7\u6309\u9700\u8bca\u65ad\u666e\u53ca\u75be\u75c5\u68c0\u6d4b\u3002\u5229\u7528\u5176\u5185\u90e8\u7814\u53d1\u548c\u5bf9&nbsp;Cas12\u3001Cas13\u3001Cas14 \u548c&nbsp;Cas<span id=\"spanHghlt38f1\">\u0278 <\/span>\u7684\u72ec\u5bb6\u8bb8\u53ef\uff0cMammoth \u53ef\u4ee5\u4e3a\u751f\u547d\u79d1\u5b66\u7814\u7a76\u3001\u533b\u7597\u4fdd\u5065\u3001\u519c\u4e1a\u3001\u751f\u7269\u9632\u5fa1\u7b49\u63d0\u4f9b\u589e\u5f3a\u7684\u8bca\u65ad\u548c\u57fa\u56e0\u7ec4\u7f16\u8f91\u6280\u672f\u3002&nbsp;Mammoth \u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u65e7\u91d1\u5c71\u6e7e\u533a\uff0c\u7531&nbsp;CRISPR \u5148\u9a71\u548c\u8bfa\u8d1d\u5c14\u5956\u83b7\u5f97\u8005&nbsp;Jennifer Doudna \u548c&nbsp;Trevor Martin\u3001Janice Chen \u4ee5\u53ca <span class=\"xn-person\">Lucas Harrington<\/span> \u5171\u540c\u521b\u7acb\u3002\u8be5\u516c\u53f8\u5f97\u5230\u4e86\u9876\u7ea7\u673a\u6784\u6295\u8d44\u8005\u7684\u652f\u6301\uff0c\u5305\u62ec&nbsp;Redmile Group\u3001Foresite Capital\u3001Senator Investment Group\u3001Sixth Street\u3001Decheng\u3001Mayfield\u3001NFX \u548c&nbsp;8VC\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u62ec\u62dc\u8033\u96c6\u56e2\u7ba1\u7406\u5c42\u57fa\u4e8e\u5f53\u524d\u8bbe\u60f3\u548c\u9884\u6d4b\u6240\u4f5c\u7684\u524d\u77bb\u6027\u58f0\u660e\u3002\u5404\u79cd\u5df2\u77e5\u548c\u672a\u77e5\u7684\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u548c\u5176\u5b83\u56e0\u7d20\u5747\u53ef\u80fd\u5bfc\u81f4\u516c\u53f8\u672a\u6765\u7684\u5b9e\u9645\u8fd0\u8425\u7ed3\u679c\u3001\u8d22\u52a1\u72b6\u51b5\u3001\u53d1\u5c55\u6216\u4e1a\u7ee9\u4e0e\u4e0a\u8ff0\u524d\u77bb\u6027\u8868\u8ff0\u4e2d\u6240\u4f5c\u51fa\u7684\u4f30\u8ba1\u4ea7\u751f\u91cd\u5927\u5dee\u5f02\u3002\u8fd9\u4e9b\u56e0\u7d20\u5305\u62ec\u5728\u62dc\u8033\u5b98\u65b9\u7f51\u7ad9 <a target=\"_blank\" href=\"http:\/\/www.bayer.com\/\" rel=\"nofollow noopener\">http:\/\/www.bayer.com\/<\/a> \u4e0a\u516c\u5f00\u7684\u62dc\u8033\u5404\u9879\u62a5\u544a\u3002\u672c\u516c\u53f8\u6ca1\u6709\u8d23\u4efb\u66f4\u65b0\u8fd9\u4e9b\u524d\u77bb\u6027\u58f0\u660e\u6216\u4f7f\u5176\u7b26\u5408\u672a\u6765\u53d1\u751f\u7684\u4e8b\u4ef6\u6216\u53d1\u5c55\u3002<\/p>\n\n","protected":false},"excerpt":{"rendered":"<p>\u534f\u8bae\u8fdb\u4e00\u6b65\u5f3a\u5316\u4e86\u62dc\u8033\u65b0\u5efa\u7acb\u7684\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u5e73\u53f0 \u652f\u6301 Mammoth \u81f4\u529b\u4e8e\u5b9e\u73b0\u65b0\u578b CRISPR \u7cfb\u7edf\u5168\u90e8\u6f5c\u529b\u7684\u613f\u666f Mammoth \u5c06\u83b7\u5f97 4,000 \u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u8d85\u8fc7 10 \u4ebf\u7f8e\u5143\u7684\u672a\u6765\u6f5c\u5728\u7684\u91cc\u7a0b\u7891\u6b3e\u9879 \u5fb7\u56fd\u67cf\u6797\u548c\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5e03\u91cc\u65af\u73ed2022\u5e741\u670812\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u62dc\u8033\u96c6\u56e2\u4e0e&nbsp;Mammoth Biosciences \u516c\u53f8\uff08\u7b80\u79f0Mammoth\uff09\u4e8e 2022 \u5e74&nbsp;1 \u6708&nbsp;10 \u65e5\u5ba3\u5e03\u4e00\u9879\u6218\u7565\u5408\u4f5c\u4e0e\u9009\u62e9\u6743\u534f\u8bae\uff0c\u65e8\u5728\u5229\u7528&nbsp;Mammoth \u7684&nbsp;CRISPR \u7cfb\u7edf\u5f00\u53d1\u4f53\u5185\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u3002\u76ee\u524d Mammoth \u516c\u53f8\u6b63\u5728\u5229\u7528\u81ea\u7136\u591a\u6837\u6027\u9a71\u52a8\u4e0b\u4e00\u4ee3 CRISPR \u4ea7\u54c1\u3002 Mammoth \u516c\u53f8\u5f00\u521b\u6027\u7684\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u662f\u4e00\u9879\u5173\u952e\u6280\u672f\uff0c\u540c\u65f6\u4e5f\u662f\u5355\u72ec\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u5b83\u5c06\u6781\u5927\u5730\u589e\u5f3a\u62dc\u8033\u7684\u521b\u65b0\u80fd\u529b\uff0c\u66f4\u5feb\u5730\u5f00\u53d1\u80fd\u4e3a\u60a3\u8005\u5e26\u6765\u663e\u8457\u5f71\u54cd\u7684\u7597\u6cd5\uff0c\u5e76\u8fdb\u4e00\u6b65\u5f3a\u5316\u516c\u53f8\u8fd1\u671f\u5efa\u7acb\u7684\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u5e73\u53f0\u3002\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u4e24\u5bb6\u516c\u53f8\u5373\u5c06\u5f00\u5c55\u7684\u5408\u4f5c\uff0c\u5c06\u4ee5\u809d\u810f\u9776\u5411\u75be\u75c5\u4e3a\u91cd\u70b9\u3002 \u62dc\u8033\u96c6\u56e2\u7ba1\u7406\u59d4\u5458\u4f1a\u6210\u5458\u3001\u62dc\u8033\u5904\u65b9\u836f\u5168\u7403\u603b\u88c1&nbsp;Stefan Oelrich \u8bf4\uff1a\u201cMammoth \u7684\u65b0\u578b&nbsp;CRISPR \u7cfb\u7edf\u4e0e\u516c\u53f8\u73b0\u6709\u7684\u57fa\u56e0\u589e\u5f3a\u53ca\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de&nbsp;(iPSC) \u5e73\u53f0\u76f8\u7ed3\u5408\uff0c\u5c06\u91ca\u653e\u6211\u4eec\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u7b56\u7565\u7684\u5168\u90e8\u6f5c\u529b\u3002\u4e0e&nbsp;Mammoth \u9876\u5c16\u79d1\u7814\u56e2\u961f\u5408\u4f5c\u662f\u4e00\u4e2a\u91cd\u8981\u652f\u67f1\uff0c\u5c06\u652f\u6301\u6211\u4eec\u6539\u5584\u90a3\u4e9b\u8eab\u60a3\u76ee\u524d\u96be\u6cbb\u578b\u75be\u75c5\u60a3\u8005\u7684\u751f\u6d3b\u3002\u201d Mammoth \u516c\u53f8\u9996\u5e2d\u5546\u52a1\u5b98\u517c\u6cbb\u7597\u6218\u7565\u8d1f\u8d23\u4eba&nbsp;Peter Nell \u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u4e0e\u62dc\u8033\u5408\u4f5c\u3002\u57fa\u4e8e\u6211\u4eec\u65b0\u578b&nbsp;CRISPR \u7cfb\u7edf\u6280\u672f\u98de\u8dc3\uff0c\u8fd9\u9879\u5408\u4f5c\u7ed3\u5408\u4e86\u62dc\u8033\u5728\u836f\u7269\u5f00\u53d1\u9886\u57df\u7684\u4f18\u52bf\u4e13\u957f\u3002\u5728\u53cc\u65b9\u7684\u5171\u540c\u52aa\u529b\u4e0b\uff0c\u6211\u4eec\u5c06\u6709\u53ef\u80fd\u901a\u8fc7\u5f00\u53d1\u57fa\u4e8e&nbsp;CRISPR \u7684\u65b9\u6cd5\u4ee5\u6ee1\u8db3\u4e34\u5e8a\u6240\u9762\u4e34\u7684\u9002\u5f53\u7d27\u8feb\u6027\uff0c\u4f7f\u60a3\u8005\u53d7\u76ca\uff0c\u540c\u65f6\u786e\u4fdd\u5b66\u672f\u7684\u5353\u8d8a\u6027\u4e0e\u5b89\u5168\u6027\u3002\u201d \u7ec6\u80de\u548c\u57fa\u56e0\u7597\u6cd5\u662f\u836f\u7269\u5f00\u53d1\u9886\u57df\u53d1\u5c55\u7684\u4e0b\u4e00\u9636\u6bb5\u3002\u901a\u8fc7\u89e3\u51b3\u75be\u75c5\u7684\u6839\u672c\u6210\u56e0\uff0c\u8fd9\u4e9b\u65b0\u578b\u7597\u6cd5\u5177\u6709\u901a\u8fc7\u4e00\u6b21\u6027\u6cbb\u7597\u6c38\u4e45\u9006\u8f6c\u75be\u75c5\u7684\u6f5c\u529b\u3002\u5f53\u5728\u6d3b\u4f53\u5916\uff08\u4f53\u5916\uff09\u4f7f\u7528\u65f6\uff0c\u57fa\u56e0\u7f16\u8f91\u662f\u7ec6\u80de\u7597\u6cd5\u7684\u5173\u952e\u63a8\u52a8\u529b\uff0c\u5f53\u5728\u6d3b\u4f53\u5185\uff08\u4f53\u5185\uff09\u4f7f\u7528\u65f6\uff0c\u53ef\u4ee5\u9488\u5bf9\u5177\u6709\u9ad8\u5ea6\u672a\u6ee1\u8db3\u533b\u7597\u9700\u6c42\u7684\u591a\u79cd\u9057\u4f20\u75be\u75c5\u5b9e\u73b0\u9776\u5411\u6cbb\u7597\u3002 Mammoth \u516c\u53f8\u5305\u62ec&nbsp;Cas14 \u548c&nbsp;Cas\u0278 \u5728\u5185\u7684\u8d85\u5c0f\u578b&nbsp;Cas \u9176\u4e13\u6709\u5de5\u5177\u5305\uff0c\u5141\u8bb8\u5c06\u6269\u5c55\u7684\u9ad8\u4fdd\u771f\u57fa\u56e0\u7f16\u8f91\u4e0e\u9776\u5411\u7cfb\u7edf\u9012\u9001\u76f8\u7ed3\u5408\u3002\u6839\u636e\u534f\u8bae\uff0c\u62dc\u8033\u6709\u6743\u4f7f\u7528\u8fd9\u4e00\u65b0\u578b\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u3002\u57fa\u4e8e\u8fd9\u4e9b\u65b0\u578b&nbsp;CRISPR \u7cfb\u7edf\u7684\u8d85\u7d27\u51d1\u5c3a\u5bf8\uff0c\u8be5\u6280\u672f\u5177\u6709\u4f18\u8d8a\u7684\u4f53\u5185\u5e94\u7528\u6f5c\u529b\u3002 \u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0cMammoth \u516c\u53f8\u5c06\u83b7\u5f97&nbsp;4,000 \u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\uff0c\u5e76\u6709\u8d44\u683c\u83b7\u5f97\u76ee\u6807\u671f\u6743\u884c\u6743\u8d39\u7528\u4ee5\u53ca\u8d85\u8fc7&nbsp;10 \u4ebf\u7f8e\u5143\u7684\u672a\u6765\u6f5c\u5728\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u8fd9\u4e9b\u4ed8\u6b3e\u57fa\u4e8e\u6210\u529f\u5b8c\u6210\u7279\u5b9a\u7814\u7a76\u3001\u5f00\u53d1\u4ee5\u53ca\u5546\u4e1a\u7b49\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff0c\u6d89\u53ca\u4e94\u4e2a\u9884\u5148\u9009\u62e9\u7684\u4f53\u5185\u9002\u5e94\u75c7\uff0c\u5176\u4e2d\u9996\u5148\u5173\u6ce8\u809d\u810f\u9776\u5411\u75be\u75c5\u3002\u6b64\u5916\uff0c\u62dc\u8033\u5c06\u652f\u4ed8\u7814\u7a76\u7ecf\u8d39\u4ee5\u53ca\u5206\u5c42\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\uff0c\u6700\u9ad8\u53ef\u8fbe\u51c0\u9500\u552e\u989d\u7684\u4e24\u4f4d\u6570\u767e\u5206\u6bd4\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u4e24\u5bb6\u516c\u53f8\u8fd8\u6b63\u5728\u975e\u6392\u4ed6\u6027\u57fa\u7840\u4e0a\u63a2\u7d22\u4f53\u5916\u9879\u76ee\u76f8\u5173\u5de5\u4f5c\u3002 \u5173\u4e8e\u62dc\u8033&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2022011213130059822\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-59822","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/59822","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=59822"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/59822\/revisions"}],"predecessor-version":[{"id":59823,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/59822\/revisions\/59823"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=59822"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=59822"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=59822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}