{"id":59556,"date":"2022-01-11T04:30:00","date_gmt":"2022-01-10T21:30:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022011104300059556"},"modified":"2022-01-11T17:57:24","modified_gmt":"2022-01-11T09:57:24","slug":"sana-biotechnology%e3%80%81%e9%a9%af%e9%b9%bf%e5%8c%bb%e7%96%97%e3%80%81%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%85%b1%e5%90%8c%e5%ae%a3%e5%b8%83%e5%b0%b1%e7%bb%8f%e4%b8%b4%e5%ba%8a%e9%aa%8c%e8%af%81","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022011104300059556","title":{"rendered":"Sana Biotechnology\u3001\u9a6f\u9e7f\u533b\u7597\u3001\u4fe1\u8fbe\u751f\u7269\u5171\u540c\u5ba3\u5e03\u5c31\u7ecf\u4e34\u5e8a\u9a8c\u8bc1\u7684BCMA CAR\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u548c\u975e\u72ec\u5bb6\u8bb8\u53ef\u534f\u8bae"},"content":{"rendered":"

\u6b64\u9879\u534f\u8bae\u5c06\u9a6f\u9e7f\u533b\u7597\u4e0e\u4fe1\u8fbe\u751f\u7269\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5df2\u88ab\u9a8c\u8bc1\u7684CAR\u7ed3\u6784\u4e0eSana\u7684\u4f53\u5185\u548c\u4f53\u5916\u5de5\u7a0b\u7ec6\u80de\u6cbb\u7597\u9879\u76ee\u8fdb\u884c\u6709\u673a\u7ed3\u5408<\/span><\/p>\n\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7f8e\u56fd\u897f\u96c5\u56fe\u3001\u534e\u76db\u987f\u3001\u65e7\u91d1\u5c71\u3001\u5723\u8377\u897f\u3001\u4e2d\u56fd\u5357\u4eac\u3001\u82cf\u5dde\u548c\u4e0a\u6d772022\u5e741\u670811\u65e5 \/\u7f8e\u901a\u793e\/ — Sana Biotechnology, Inc.\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aSANA\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u521b\u9020\u548c\u63d0\u4f9b\u5de5\u7a0b\u7ec6\u80de\u836f\u7269\u7684\u516c\u53f8\uff0c\u9a6f\u9e7f\u533b\u7597\uff08\u201cIASO Bio\u201d\uff09\uff0c\u4e00\u5bb6\u4ece\u4e8b\u53d1\u73b0\u3001\u5f00\u53d1\u548c\u5236\u9020\u521b\u65b0\u836f\u7269\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4ee5\u53ca\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff0c\u4ee5\u4e0b\u7b80\u79f0 \u201c\u4fe1\u8fbe\u751f\u7269\u201d\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u5929\u8054\u5408\u5ba3\u5e03\uff0c\u9a6f\u9e7f\u533b\u7597\u4e0e\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u6388\u4e88Sana\u5176\u7ecf\u4e34\u5e8a\u9a8c\u8bc1\u7684\u5168\u4eba\u6e90 BCMA CAR \u7ed3\u6784\u7684\u975e\u72ec\u5bb6\u5546\u4e1a\u6743\u5229\uff0c\u5e94\u7528\u4e8eSana\u7279\u5b9a\u7684\u4f53\u5185\u57fa\u56e0\u6cbb\u7597(in vivo gene therapy)\u548c\u4f53\u5916\u4f4e\u514d\u75ab(ex vivo hypoimmune) \u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u5f00\u53d1\u3002\u9a6f\u9e7f\u533b\u7597\u548c\u4fe1\u8fbe\u751f\u7269\u5c06\u83b7\u5f97Sana\u652f\u4ed8\u4e00\u7b14\u9996\u4ed8\u6b3e\u4ee5\u53ca\u6709\u8d44\u683c\u83b7\u5f97\u6700\u591a6\u4e2a\u4ea7\u54c1\u3001\u7ea6\u4e3a2.04\u4ebf\u7f8e\u5143\u7684\u6f5c\u5728\u5f00\u53d1\u3001\u6ce8\u518c\u91cc\u7a0b\u7891\u4ed8\u6b3e\u548c\u9500\u552e\u5206\u6210\u3002<\/p>\n

\n<\/p><\/div>\n

\u5728\u9488\u5bf9\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u6cbb\u7597\u4e2d\uff0cB\u7ec6\u80de\u6210\u719f\u6297\u539f\uff08BCMA\uff09\u5df2\u88ab\u8bc1\u5b9e\u53ef\u4f5c\u4e3a\u81ea\u4f53CAR T\u7597\u6cd5\u7684\u7279\u5f02\u6027\u9776\u70b9\u3002\u6b64\u6b21\u6388\u4e88Sana\u7684BCMA CAR\u662f\u9a6f\u9e7f\u533b\u7597\u4e0e\u4fe1\u8fbe\u751f\u7269\u5408\u4f5c\u5f00\u53d1\u7684\u4e00\u9879\u9776\u5411BCMA\u7684\u81ea\u4f53CAR T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\uff08\u9a6f\u9e7f\u533b\u7597\u7814\u53d1\u4ee3\u53f7\uff1aCT103A\uff0c\u4fe1\u8fbe\u751f\u7269\u7814\u53d1\u4ee3\u53f7\uff1aIBI326\uff09\u4e2d\u7684\u5173\u952e\u6210\u5206\uff0c\u8be5\u4ea7\u54c1\u5728\u4e2d\u56fd\u83b7\u5f97\u4e86\u826f\u597d\u7684\u4e34\u5e8a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002\u8fd1\u65e5\u4e3e\u884c\u7684\u7f8e\u56fd63\u5c4a\u8840\u6db2\u5b66\u5e74\u4f1a\u4e0a\uff0c\u9a6f\u9e7f\u548c\u4fe1\u8fbe\u8054\u5408\u516c\u5e03\u4e86\u6700\u65b0\u4e34\u5e8a1\/2\u671f\u6570\u636e\u3002\u6570\u636e\u663e\u793a\uff0cCT103A\u572879\u540d\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u9aa8\u9ad3\u7624\u60a3\u8005\u4e2d\u8fbe\u5230\u4e86\u4f18\u8d8a\u7684\u603b\u4f53\u7f13\u89e3\u7387\uff08ORR\uff0994.9%\uff0c\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u9634\u6027\u7387\u4e3a93.7%\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\/\u4e25\u683c\u610f\u4e49\u7684\u5b8c\u5168\u7f13\u89e3\uff08CR\/sCR\uff09\u4e3a58.2%\u3002CT103A\u5728\u65e2\u5f80\u63a5\u53d7\u8fc7BCMA CAR-T\u7597\u6cd5\u7684\u60a3\u8005\u4e2d\u4e5f\u663e\u793a\u51fa\u826f\u597d\u6cbb\u7597\u6548\u679c\uff0c13\u4f8b\u65e2\u5f80\u63a5\u53d7CAR-T\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u7684ORR\u4e3a76.9%\uff0c61.5%\u8fbe\u5230\u975e\u5e38\u597d\u7684\u90e8\u5206\u7f13\u89e3\uff08VGPR\uff09\u53ca\u4ee5\u4e0a\uff0cCR\/sCR\u4e3a46.2%\u30022021\u5e742\u6708\uff0cCT103A\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40 (NMPA) \u201c\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u201d\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002<\/p>\n

Sana\u516c\u53f8 T\u7ec6\u80de\u7597\u6cd5\u90e8\u95e8\u8d1f\u8d23\u4ebaTerry Fry\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u81f4\u529b\u4e8e\u6ee1\u8db3\u60a3\u8005\u7684\u9700\u6c42\uff0c\u6211\u4eec\u6700\u65e9\u5c06\u4e8e\u660e\u5e74\u628a\u5404\u9879\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u9879\u76ee\u63a8\u8fdb\u81f3\u4e34\u5e8a\u9636\u6bb5\u3002\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u5f97\u5230\u6765\u81ea\u9a6f\u9e7f\u53ca\u4fe1\u8fbe\u7684\u5df2\u83b7\u4e34\u5e8a\u9a8c\u8bc1\u7684\u5168\u4eba\u6e90BCMA CAR\u7ed3\u6784\u3002\u6211\u4eec\u76f8\u4fe1\uff0c\u4ee5\u8fd9\u9879\u534f\u8bae\u4e3a\u5951\u673a\uff0cSana\u5c06\u80fd\u51ed\u501ffusogen\u5e73\u53f0\uff0c\u5927\u529b\u63a8\u8fdb\u4ee5BCMA\u4e3a\u9776\u70b9\u7684\u5f02\u4f53CAR-T\u5019\u9009\u4ea7\u54c1\u3001\u4ee5\u53ca\u6211\u4eec\u7684\u4f53\u5185CAR-T\u5019\u9009\u4ea7\u54c1\u7684\u7814\u53d1\u8fdb\u5c55\u3002<\/p>\n

 \u201c\u6211\u4eec\u5f88\u9ad8\u5174\u4e0eSana\u516c\u53f8\u5408\u4f5c\uff0c\u8be5\u5206\u5b50\u5728\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u5df2\u5728\u6211\u4eec\u4e0e\u4fe1\u8fbe\u5171\u540c\u5f00\u53d1\u7684\u5168\u4eba\u6e90BCMA CAR-T\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u4ee5\u9a8c\u8bc1\uff0c\u201c\u9a6f\u9e7f\u533b\u7597\u9996\u5e2d\u6267\u884c\u5b98\u517c\u9996\u5e2d\u533b\u5b66\u5b98\u6c6a\u6587\u535a\u58eb\u8868\u793a\uff0c\u201d\u6211\u4eec\u975e\u5e38\u671f\u5f85CT103A\u7684\u66f4\u5927\u6f5c\u5728\u4ef7\u503c\u80fd\u591f\u5728Sana\u7684\u521b\u65b0\u4ea7\u54c1\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u8fc7\u7a0b\u4e2d\u5f97\u4ee5\u4f53\u73b0\uff0c\u4ee5\u60e0\u53ca\u66f4\u591a\u75c5\u4eba\u3002\u540c\u65f6\uff0c\u9a6f\u9e7f\u548c\u4fe1\u8fbe\u4e5f\u5c06\u83b7\u5f97Sana\u7684\u4e0b\u4e00\u4ee3\u7ec6\u80de\u57fa\u56e0\u4ea7\u54c1\u5728\u5927\u4e2d\u534e\u5730\u533a\u7684\u4f18\u5148\u6743\uff0c\u8fd9\u5bf9\u4e8e\u9a6f\u9e7f\u52a0\u5f3a\u81ea\u8eab\u7ba1\u7ebf\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u201d<\/p>\n

\u201c\u4fe1\u8fbe\u5f88\u9ad8\u5174\u4e0e\u9a6f\u9e7f\u5171\u540c\u5f00\u53d1\u548c\u4e34\u5e8a\u9a8c\u8bc1\u7684BCMA CAR\u7ed3\u6784\uff0c\u5f97\u5230Sana\u516c\u53f8\u7684\u8ba4\u53ef\uff0c\u201c \u4fe1\u8fbe\u751f\u7269\u526f\u603b\u88c1\u517c\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u8d1f\u8d23\u4eba\u5f90\u4f1f\u535a\u58eb\u8868\u793a\uff0c\u201d\u672c\u6b21\u6388\u6743\u5408\u4f5c\u4f7fSana\u80fd\u591f\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u901a\u8fc7\u5176\u72ec\u5bb6\u4e13\u5229\u6280\u672f\uff0c\u5f00\u53d1\u51fa\u4e0b\u4e00\u4ee3\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\uff0c\u9020\u798f\u5168\u7403\u8303\u56f4\u5185\u66f4\u591a\u7684\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u3002\u4fe1\u8fbe\u548c\u9a6f\u9e7f\u4e5f\u671f\u5f85\u4e0eSana\u5728\u4e2d\u56fd\u5730\u533a\u8fbe\u6210\u4e0b\u4e00\u6b65\u5408\u4f5c\uff0c\u653b\u514b\u66f4\u591a\u590d\u6742\u75be\u75c5\u3002\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6b64\u9879\u534f\u8bae\u5c06\u9a6f\u9e7f\u533b\u7597\u4e0e\u4fe1\u8fbe\u751f\u7269\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5df2\u88ab\u9a8c\u8bc1\u7684CAR\u7ed3\u6784\u4e0eSana\u7684\u4f53\u5185\u548c\u4f53\u5916\u5de5\u7a0b\u7ec6\u80de\u6cbb\u7597\u9879\u76ee\u8fdb\u884c\u6709\u673a\u7ed3\u5408 \u7f8e\u56fd\u897f\u96c5\u56fe\u3001\u534e\u76db\u987f\u3001\u65e7\u91d1\u5c71\u3001\u5723\u8377\u897f\u3001\u4e2d\u56fd\u5357\u4eac\u3001\u82cf\u5dde\u548c\u4e0a\u6d772022\u5e741\u670811\u65e5 \/\u7f8e\u901a\u793e\/ — Sana Biotechnology, Inc.\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aSANA\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u521b\u9020\u548c\u63d0\u4f9b\u5de5\u7a0b\u7ec6\u80de\u836f\u7269\u7684\u516c\u53f8\uff0c\u9a6f\u9e7f\u533b\u7597\uff08\u201cIASO Bio\u201d\uff09\uff0c\u4e00\u5bb6\u4ece\u4e8b\u53d1\u73b0\u3001\u5f00\u53d1\u548c\u5236\u9020\u521b\u65b0\u836f\u7269\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4ee5\u53ca\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff0c\u4ee5\u4e0b\u7b80\u79f0 \u201c\u4fe1\u8fbe\u751f\u7269\u201d\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u5929\u8054\u5408\u5ba3\u5e03\uff0c\u9a6f\u9e7f\u533b\u7597\u4e0e\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u6388\u4e88Sana\u5176\u7ecf\u4e34\u5e8a\u9a8c\u8bc1\u7684\u5168\u4eba\u6e90 BCMA CAR 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