{"id":59549,"date":"2022-01-11T04:30:00","date_gmt":"2022-01-10T21:30:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022011104300059549"},"modified":"2022-01-11T17:56:09","modified_gmt":"2022-01-11T09:56:09","slug":"sana-biotechnology%ef%bc%8c%e9%a9%af%e9%b9%bf%e5%8c%bb%e7%96%97%ef%bc%8c%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%85%b1%e5%90%8c%e5%ae%a3%e5%b8%83%e5%b0%b1%e7%bb%8f%e4%b8%b4%e5%ba%8a%e9%aa%8c%e8%af%81","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022011104300059549","title":{"rendered":"Sana Biotechnology\uff0c\u9a6f\u9e7f\u533b\u7597\uff0c\u4fe1\u8fbe\u751f\u7269\u5171\u540c\u5ba3\u5e03\u5c31\u7ecf\u4e34\u5e8a\u9a8c\u8bc1\u7684BCMA CAR\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u548c\u975e\u72ec\u5bb6\u8bb8\u53ef\u534f\u8bae"},"content":{"rendered":"

\u6b64\u9879\u534f\u8bae\u5c06\u9a6f\u9e7f\u533b\u7597\u4e0e\u4fe1\u8fbe\u751f\u7269\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5df2\u88ab\u9a8c\u8bc1\u7684CAR\u7ed3\u6784\u4e0eSana\u7684\u4f53\u5185\u548c\u4f53\u5916\u5de5\u7a0b\u7ec6\u80de\u6cbb\u7597\u9879\u76ee\u8fdb\u884c\u6709\u673a\u7ed3\u5408<\/span><\/p>\n

\u897f\u96c5\u56fe\u3001\u534e\u76db\u987f\u3001\u7f8e\u56fd\u65e7\u91d1\u5c71\u3001\u5723\u8377\u897f\u3001\u5357\u4eac\u3001\u82cf\u5dde\u548c\u4e0a\u6d772022\u5e741\u670811\u65e5 \/\u7f8e\u901a\u793e\/ — Sana Biotechnology, Inc.\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aSANA\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u521b\u9020\u548c\u63d0\u4f9b\u5de5\u7a0b\u7ec6\u80de\u836f\u7269\u7684\u516c\u53f8\uff0c\u9a6f\u9e7f\u533b\u7597\uff08“IASO Bio”\uff09\uff0c\u4e00\u5bb6\u4ece\u4e8b\u53d1\u73b0\u3001\u5f00\u53d1\u548c\u5236\u9020\u521b\u65b0\u836f\u7269\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4ee5\u53ca\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff0c\u4ee5\u4e0b\u7b80\u79f0 “\u4fe1\u8fbe\u751f\u7269”\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u5929\u8054\u5408\u5ba3\u5e03\uff0c\u9a6f\u9e7f\u533b\u7597\u4e0e\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u6388\u4e88Sana\u5176\u7ecf\u4e34\u5e8a\u9a8c\u8bc1\u7684\u5168\u4eba\u6e90 BCMA CAR \u7ed3\u6784\u7684\u975e\u72ec\u5bb6\u5546\u4e1a\u6743\u5229\uff0c\u5e94\u7528\u4e8eSana\u7279\u5b9a\u7684\u4f53\u5185\u57fa\u56e0\u6cbb\u7597(in vivo gene therapy)\u548c\u4f53\u5916\u4f4e\u514d\u75ab(ex vivo hypoimmune) \u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u5f00\u53d1\u3002\u9a6f\u9e7f\u533b\u7597\u548c\u4fe1\u8fbe\u751f\u7269\u5c06\u83b7\u5f97Sana\u652f\u4ed8\u4e00\u7b14\u9996\u4ed8\u6b3e\u4ee5\u53ca\u6709\u8d44\u683c\u83b7\u5f97\u6700\u591a6\u4e2a\u4ea7\u54c1\u3001\u7ea6\u4e3a2.04\u4ebf\u7f8e\u5143\u7684\u6f5c\u5728\u5f00\u53d1\u3001\u6ce8\u518c\u91cc\u7a0b\u7891\u4ed8\u6b3e\u548c\u9500\u552e\u5206\u6210\u3002<\/p>\n

\u5728\u9488\u5bf9\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u6cbb\u7597\u4e2d\uff0cB\u7ec6\u80de\u6210\u719f\u6297\u539f\uff08BCMA\uff09\u5df2\u88ab\u8bc1\u5b9e\u53ef\u4f5c\u4e3a\u81ea\u4f53CAR T\u7597\u6cd5\u7684\u7279\u5f02\u6027\u9776\u70b9\u3002\u6b64\u6b21\u6388\u4e88Sana\u7684BCMA CAR\u662f\u9a6f\u9e7f\u533b\u7597\u4e0e\u4fe1\u8fbe\u751f\u7269\u5408\u4f5c\u5f00\u53d1\u7684\u4e00\u9879\u9776\u5411BCMA\u7684\u81ea\u4f53CAR T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\uff08\u4fe1\u8fbe\u751f\u7269\u7814\u53d1\u4ee3\u53f7\uff1aIBI326\uff0c\u9a6f\u9e7f\u533b\u7597\u7814\u53d1\u4ee3\u53f7\uff1aCT103A\uff09\u4e2d\u7684\u5173\u952e\u6210\u5206\uff0c\u8be5\u4ea7\u54c1\u5728\u4e2d\u56fd\u83b7\u5f97\u4e86\u826f\u597d\u7684\u4e34\u5e8a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002\u8fd1\u65e5\u4e3e\u884c\u7684\u7f8e\u56fd63\u754c\u8840\u6db2\u5b66\u5e74\u4f1a\u4e0a\uff0c\u4fe1\u8fbe\u751f\u7269\u548c\u9a6f\u9e7f\u533b\u7597\u8054\u5408\u516c\u5e03\u4e86\u6700\u65b0\u4e34\u5e8a1\/2\u671f\u7814\u7a76\u6570\u636e\u3002\u6570\u636e\u663e\u793a\uff0cIBI326\u572879\u540d\u591a\u53d1\u96be\u6cbb\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u4e2d\u8fbe\u5230\u4e86\u4f18\u8d8a\u7684\u603b\u4f53\u7f13\u89e3\u7387\uff08ORR\uff0994.9%\uff0c\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u9634\u6027\u7387\u4e3a93.7%\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\/\u4e25\u683c\u610f\u4e49\u7684\u5b8c\u5168\u7f13\u89e3\uff08CR\/sCR\uff09\u4e3a58.2%\u3002IBI326\u5728\u65e2\u5f80\u63a5\u53d7\u8fc7BCMA CAR-T\u7597\u6cd5\u7684\u60a3\u8005\u4e2d\u4e5f\u663e\u793a\u51fa\u826f\u597d\u6cbb\u7597\u6548\u679c\uff0c13\u4f8b\u65e2\u5f80\u63a5\u53d7CAR-T\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u7684ORR\u4e3a76.9%\uff0c61.5%\u8fbe\u5230\u975e\u5e38\u597d\u7684\u90e8\u5206\u7f13\u89e3\uff08VGPR\uff09\u53ca\u4ee5\u4e0a\uff0cCR\/sCR\u4e3a46.2%\u30022021\u5e742\u6708\uff0cIBI326\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40 (NMPA) “\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269”\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002<\/p>\n

“\u4fe1\u8fbe\u5f88\u9ad8\u5174\u4e0e\u9a6f\u9e7f\u5171\u540c\u5f00\u53d1\u548c\u4e34\u5e8a\u9a8c\u8bc1\u7684BCMA CAR\u7ed3\u6784\uff0c\u5f97\u5230Sana\u516c\u53f8\u7684\u8ba4\u53ef\uff0c”\u4fe1\u8fbe\u751f\u7269\u526f\u603b\u88c1\u517c\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u8d1f\u8d23\u4eba\u5f90\u4f1f\u535a\u58eb<\/strong>\u8868\u793a\uff0c“\u672c\u6b21\u6388\u6743\u5408\u4f5c\u4f7fSana\u80fd\u591f\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u901a\u8fc7\u5176\u72ec\u5bb6\u4e13\u5229\u6280\u672f\uff0c\u5f00\u53d1\u51fa\u4e0b\u4e00\u4ee3\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\uff0c\u9020\u798f\u5168\u7403\u8303\u56f4\u5185\u66f4\u591a\u7684\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u3002\u4fe1\u8fbe\u548c\u9a6f\u9e7f\u4e5f\u671f\u5f85\u4e0eSana\u5728\u4e2d\u56fd\u5730\u533a\u8fbe\u6210\u4e0b\u4e00\u6b65\u5408\u4f5c\uff0c\u653b\u514b\u66f4\u591a\u590d\u6742\u75be\u75c5\u3002”<\/p>\n

“\u6211\u4eec\u5f88\u9ad8\u5174\u4e0eSana\u516c\u53f8\u5408\u4f5c\uff0c\u8be5\u5206\u5b50\u5728\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u5df2\u5728\u6211\u4eec\u4e0e\u4fe1\u8fbe\u5171\u540c\u5f00\u53d1\u7684\u5168\u4eba\u6e90BCMA CAR-T\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u4ee5\u9a8c\u8bc1\uff0c”\u9a6f\u9e7f\u533b\u7597\u9996\u5e2d\u6267\u884c\u5b98\u517c\u9996\u5e2d\u533b\u5b66\u5b98\u6c6a\u6587\u535a\u58eb<\/strong>\u8868\u793a\uff0c“\u6211\u4eec\u975e\u5e38\u671f\u5f85CT103A\u7684\u66f4\u5927\u6f5c\u5728\u4ef7\u503c\u80fd\u591f\u5728Sana\u7684\u521b\u65b0\u4ea7\u54c1\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u8fc7\u7a0b\u4e2d\u5f97\u4ee5\u4f53\u73b0\uff0c\u4ee5\u60e0\u53ca\u66f4\u591a\u75c5\u4eba\u3002\u540c\u65f6\uff0c\u9a6f\u9e7f\u548c\u4fe1\u8fbe\u4e5f\u5c06\u83b7\u5f97Sana\u7684\u4e0b\u4e00\u4ee3\u7ec6\u80de\u57fa\u56e0\u4ea7\u54c1\u5728\u5927\u4e2d\u534e\u5730\u533a\u7684\u4f18\u5148\u6743\uff0c\u8fd9\u5bf9\u4e8e\u9a6f\u9e7f\u52a0\u5f3a\u81ea\u8eab\u7ba1\u7ebf\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002”<\/p>\n

Sana<\/strong>\u516c\u53f8<\/strong>T<\/strong>\u7ec6\u80de\u7597\u6cd5\u90e8\u95e8\u8d1f\u8d23\u4eba<\/strong>Terry Fry<\/span><\/strong>\u535a\u58eb<\/strong>\u8868\u793a\uff1a“\u6211\u4eec\u81f4\u529b\u4e8e\u6ee1\u8db3\u60a3\u8005\u7684\u9700\u6c42\uff0c\u6211\u4eec\u6700\u65e9\u5c06\u4e8e\u660e\u5e74\u628a\u5404\u9879\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u9879\u76ee\u63a8\u8fdb\u81f3\u4e34\u5e8a\u9636\u6bb5\u3002\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u5f97\u5230\u6765\u81ea\u9a6f\u9e7f\u53ca\u4fe1\u8fbe\u7684\u5df2\u83b7\u4e34\u5e8a\u9a8c\u8bc1\u7684\u5168\u4eba\u6e90BCMA CAR\u7ed3\u6784\u3002\u6211\u4eec\u76f8\u4fe1\uff0c\u4ee5\u8fd9\u9879\u534f\u8bae\u4e3a\u5951\u673a\uff0cSana\u5c06\u80fd\u51ed\u501ffusogen\u5e73\u53f0\uff0c\u5927\u529b\u63a8\u8fdb\u4ee5BCMA\u4e3a\u9776\u70b9\u7684\u5f02\u4f53CAR-T\u5019\u9009\u4ea7\u54c1\uff0c\u4ee5\u53ca\u6211\u4eec\u7684\u4f53\u5185CAR-T\u5019\u9009\u4ea7\u54c1\u7684\u7814\u53d1\u8fdb\u5c55\u3002”<\/p>\n

\u5173\u4e8e<\/strong> IBI326\/CT103A (BCMA CAR-T)<\/strong><\/p>\n

IBI326\u662f\u7531\u4fe1\u8fbe\u751f\u7269\u548c\u9a6f\u9e7f\u533b\u7597\u8054\u5408\u5f00\u53d1\u7684\u4e00\u79cd\u521b\u65b0\u4ea7\u54c1\u3002\u672c\u4ea7\u54c1\u4ee5\u6162\u75c5\u6bd2\u4e3a\u57fa\u56e0\u8f7d\u4f53\u8f6c\u67d3\u81ea\u4f53T\u7ec6\u80de\uff0cCAR\u5305\u542b\u5168\u4eba\u6e90scFv\u3001CD8a \u94f0\u94fe\u548c\u8de8\u819c\u30014-1BB\u5171\u523a\u6fc0\u548cCD3ζ\u6fc0\u6d3b\u7ed3\u6784\u57df\u3002\u57fa\u4e8e\u4e25\u683c\u7684\u7b5b\u9009\uff0c\u901a\u8fc7\u5168\u9762\u7684\u4f53\u5185\u5916\u529f\u80fd\u8bc4\u4ef7\uff0cIBI326 \u5df2\u5728\u4e2d\u56fd\u663e\u793a\u51fa\u6709\u4f18\u8d8a\u7684\u7597\u6548\u6570\u636e\u30022021\u5e742\u6708\uff0cIBI326\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40 (NMPA) \u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3(CDE)“\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269”\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002\u9664\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u5916\uff0c\u9a6f\u9e7f\u533b\u7597\u8fd8\u5728\u7814\u7a76 IBI326 \u5728\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u60a3\u8005\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n

\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/strong><\/p>\n

“\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c”\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u7406\u60f3\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u30022018\u5e7410\u670831\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a01801\u3002<\/p>\n

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\u4fe1\u8fbe\u751f\u7269\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u5177\u6709\u56fd\u9645\u5148\u8fdb\u6c34\u5e73\u7684\u9ad8\u7aef\u751f\u7269\u836f\u5f00\u53d1\u3001\u4ea7\u4e1a\u5316\u4eba\u624d\u56e2\u961f\uff0c\u5305\u62ec\u4f17\u591a\u6d77\u5f52\u4e13\u5bb6\uff0c\u5e76\u4e0e\u7f8e\u56fd\u793c\u6765\u5236\u836f\u3001Adimab\u3001Incyte\u3001MD Anderson \u764c\u75c7\u4e2d\u5fc3\u548c\u97e9\u56fdHanmi\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1awww.innoventbio.com<\/a> \u6216\u516c\u53f8\u9886\u82f1\u8d26\u53f7www.linkedin.com\/company\/innovent-biologics\/<\/a>\u3002 <\/p>\n

\u6ce8\u660e\uff1a<\/p>\n

TYVYT®<\/sup> (\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2)\u5728\u7f8e\u56fd\u4e0d\u662f\u83b7\u5f97\u6279\u51c6\u7684\u4ea7\u54c1\u3002<\/p>\n

BYVASDA®<\/sup>\uff08\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff09\uff0c SULINNO®<\/sup> \u548cHALPRYZA®<\/sup>\uff08\u5229\u59a5\u6614\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff09\u5728\u7f8e\u56fd\u4e0d\u662f\u83b7\u5f97\u6279\u51c6\u7684\u4ea7\u54c1\u3002<\/p>\n

TYVYT®<\/sup> (\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2, \u4fe1\u8fbe\u751f\u7269)<\/p>\n

BYVASDA®<\/sup>\uff08\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f, \u4fe1\u8fbe\u751f\u7269\uff09<\/p>\n

HALPRYZA®<\/sup>\uff08\u5229\u59a5\u6614\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f,\u4fe1\u8fbe\u751f\u7269\uff09<\/p>\n

SULINNO®<\/sup> (\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f, \u4fe1\u8fbe\u751f\u7269)<\/p>\n

Pemazyre®<\/sup>\uff08pemigatinib\u53e3\u670d\u6291\u5236\u5242\uff0c Incyte Corporation\uff09. Pemazyre®<\/sup>\u7531 Incyte Corporation \u53d1\u73b0\u5e76\u6388\u6743\u8bb8\u53ef Innovent \u5728\u4e2d\u56fd\u5927\u9646\u3001\u9999\u6e2f\u3001\u6fb3\u95e8\u548c\u53f0\u6e7e\u8fdb\u884c\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u3002<\/p>\n

\u58f0\u660e\uff1a<\/p>\n

1. \u8be5\u9002\u5e94\u75c7\u4e3a\u7814\u7a76\u4e2d\u7684\u836f\u54c1\u7528\u6cd5\uff0c\u5c1a\u672a\u5728\u4e2d\u56fd\u83b7\u6279\uff1b<\/p>\n

2. \u4fe1\u8fbe\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u83b7\u6279\u7684\u836f\u54c1\/\u9002\u5e94\u75c7\u4f7f\u7528\uff1b<\/p>\n

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\u5173\u4e8e\u9a6f\u9e7f\u533b\u7597<\/strong><\/p>\n

\u9a6f\u9e7f\u533b\u7597\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u7ec6\u80de\u6cbb\u7597\u548c\u6297\u4f53\u836f\u7269\u5f00\u53d1\u548c\u4ea7\u4e1a\u5316\u7684\u521b\u65b0\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u516c\u53f8\u6210\u7acb\u4e8e2017\u5e74\uff0c\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u5728\u65b0\u836f\u7814\u53d1\u3001\u4e34\u5e8a\u7814\u7a76\u4ee5\u53ca\u5546\u4e1a\u5316\u65b9\u9762\u62e5\u6709\u4e30\u5bcc\u7ecf\u9a8c\u7684\u56fd\u9645\u5316\u7ba1\u7406\u56e2\u961f\u3002\u516c\u53f8\u4ee5\u5f00\u53d1\u8840\u6db2\u80bf\u7624\u7ec6\u80de\u7c7b\u836f\u7269\u548c\u6297\u4f53\u836f\u7269\u4e3a\u521b\u65b0\u7684\u57fa\u77f3\uff0c\u5411\u5b9e\u4f53\u7624\u548c\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u62d3\u5c55\uff0c\u62e5\u6709\u5b8c\u6574\u7684\u4ece\u65e9\u671f\u53d1\u73b0\u3001\u6ce8\u518c\u7533\u62a5\u3001\u4e34\u5e8a\u5f00\u53d1\u5230\u5546\u4e1a\u5316\u751f\u4ea7\u7684\u5168\u6d41\u7a0b\u5e73\u53f0\u80fd\u529b\u53ca\u5305\u62ec\u4e86\u5168\u4eba\u6e90\u6297\u4f53\u53d1\u73b0\u5e73\u53f0\u3001\u9ad8\u901a\u91cfCAR-T\u836f\u7269\u4f18\u9009\u5e73\u53f0\u3001\u901a\u7528CAR\u6280\u672f\u5e73\u53f0\u3001\u751f\u4ea7\u6280\u672f\u5e73\u53f0\u3001\u4e34\u5e8a\u8f6c\u5316\u7814\u7a76\u5e73\u53f0\u5728\u5185\u7684\u591a\u4e2a\u6280\u672f\u5e73\u53f0\u3002\u73b0\u670910\u4e2a\u5728\u7814\u54c1\u79cd\u5904\u4e8e\u4e0d\u540c\u7814\u53d1\u9636\u6bb5\uff0c\u5176\u4e2d\u8fdb\u5c55\u6700\u4e3a\u8fc5\u901f\u7684\u4ea7\u54c1CT103A\uff08\u5168\u4eba\u6e90BCMA\u5d4c\u5408\u6297\u539f\u53d7\u4f53\u81ea\u4f53T\u7ec6\u80de\u6ce8\u5c04\u6db2\uff09\u5df2\u5904\u4e8e\u4e34\u5e8a\u5f00\u53d1\u540e\u671f\u9636\u6bb5\uff0c\u5df2\u4e8e2021\u5e742\u6708\u88ab\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(NMPA)\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3(CDE)\u7eb3\u5165“\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269”\u54c1\u79cd\uff1b\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u521b\u65b0\u4ea7\u54c1CT120\uff08\u5168\u4eba\u6e90CD19\/CD22\u53cc\u9776\u70b9CAR-T\u7ec6\u80de\u6ce8\u5c04\u6db2\uff09\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\uff0c\u9002\u5e94\u75c7\u5206\u522b\u4e3aCD19\/CD22\u9633\u6027\u7684\u590d\u53d1\/\u96be\u6cbb\u6027B\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08B-NHL\uff09\u548c\u590d\u53d1\/\u96be\u6cbb\u6027\u6025\u6027B\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08B-ALL\uff09\uff0c\u5e76\u5df2\u83b7\u5f97FDA\u5b64\u513f\u836f\u79f0\u53f7(ODD)\u3002<\/p>\n

\u51ed\u501f\u5f3a\u6267\u884c\u529b\u7684\u7ba1\u7406\u56e2\u961f\u3001\u4e30\u5bcc\u7684\u4ea7\u54c1\u7ba1\u7ebf\u3001\u72ec\u7279\u7684\u521b\u65b0\u7814\u53d1\u4e0e\u5546\u4e1a\u6a21\u5f0f\uff0c\u9a6f\u9e7f\u533b\u7597\u6709\u5fd7\u4e8e\u6210\u4e3a\u4e1a\u754c\u6709\u5f71\u54cd\u529b\u7684\u521b\u65b0\u836f\u4f01\uff0c\u5c06\u771f\u6b63\u89e3\u51b3\u4e34\u5e8a\u75db\u70b9\u3001\u5177\u6709\u5e02\u573a\u7ade\u4e89\u529b\u7684\u521b\u65b0\u836f\u7269\u63a8\u5411\u4e34\u5e8a\u76f4\u81f3\u5e02\u573a\uff0c\u4e3a\u53d7\u8bd5\u8005\u5f00\u8f9f\u65b0\u7684\u6cbb\u7597\u9053\u8def\uff0c\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1awww.iasobio.com<\/a> \u6216\u9886\u82f1\u4e3b\u9875\uff1aIASO Biotherapeutics (\u9a6f\u9e7f\u533b\u7597)\u3002<\/p>\n

\u5173\u4e8eSana Biotechnology<\/strong><\/p>\n

Sana Biotechnology\u4e13\u6ce8\u4e8e\u4e3a\u60a3\u8005\u521b\u9020\u548c\u63d0\u4f9b\u5de5\u7a0b\u7ec6\u80de\u836f\u7269\u3002\u516c\u53f8\u7684\u613f\u666f\u662f\u4fee\u590d\u548c\u63a7\u5236\u57fa\u56e0\uff0c\u66ff\u6362\u7f3a\u5931\u6216\u53d7\u635f\u7684\u7ec6\u80de\uff0c\u5e76\u6cbb\u7597\u65b9\u6cd5\u60e0\u53ca\u5e7f\u5927\u60a3\u8005\u3002\u516c\u53f8\u73b0\u6709350\u4f59\u540d\u5458\u5de5\uff0c\u81f4\u529b\u4e8e\u957f\u671f\u670d\u52a1\u60a3\u8005\uff0c\u6539\u53d8\u4e16\u754c\u6cbb\u6108\u75be\u75c5\u7684\u65b9\u5f0f\u3002\u76ee\u524dSana\u5728\u897f\u96c5\u56fe\u3001\u5251\u6865\u548c\u5357\u65e7\u91d1\u5c71\u5747\u8bbe\u6709\u529e\u4e8b\u5904\u3002\u5982\u9700\u4e86\u89e3\u6709\u5173Sana Biotechnology\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eehttps:\/\/sana.com\/<\/a>\u3002  <\/p>\n

\u4fe1\u8fbe\u751f\u7269\u524d\u77bb\u6027\u58f0\u660e<\/strong><\/p>\n

\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528“\u9884\u671f”\u3001“\u76f8\u4fe1”\u3001“\u9884\u6d4b”\u3001“\u671f\u671b”\u3001“\u6253\u7b97”\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u5e76\u65e0\u4e49\u52a1\u4e0d\u65ad\u5730\u66f4\u65b0\u8fd9\u4e9b\u9884\u6d4b\u6027\u9648\u8ff0\u3002<\/p>\n

\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n

\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u96c7\u5458\u4ee3\u7406\u6982\u4e0d\u627f\u62c5 (a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7f51\u7ad9\u6240\u8f7d\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u4e49\u52a1\uff1b\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5b9e\u73b0\u6216\u53d8\u6210\u4e0d\u6b63\u786e\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8d23\u4efb\u3002<\/p>\n

Sana<\/strong>\u524d\u77bb\u6027\u58f0\u660e<\/strong><\/p>\n

\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u8054\u90a6\u8bc1\u5238\u6cd5\u610f\u4e49\u4e0a\u7684\u5173\u4e8eSana Biotechnology\uff08“\u516c\u53f8”\u3001“\u6211\u4eec”\u6216“\u6211\u4eec\u7684”\uff09\u7684\u524d\u77bb\u6027\u58f0\u660e\uff0c\u5305\u62ec\u4e0e\u516c\u53f8\u7684\u613f\u666f\u3001\u8fdb\u5c55\u548c\u5546\u4e1a\u8ba1\u5212\u6709\u5173\u7684\u58f0\u660e\uff1b\u5bf9\u5176\u5f00\u53d1\u9879\u76ee\u3001\u5019\u9009\u4ea7\u54c1\u548c\u6280\u672f\u5e73\u53f0\u7684\u9884\u671f\uff0c\u5305\u62ec\u5176\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u53ca\u76d1\u7ba1\u5f00\u53d1\u8ba1\u5212\u548c\u65f6\u95f4\u9884\u671f\uff1b\u5bf9\u6280\u672f\u4f7f\u7528\u548c\u6548\u76ca\u7684\u9884\u671f\uff1b\u4ee5\u53caCT103A\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u4fe1\u606f\uff0c\u5305\u62ec\u5728\u6b64\u524d\u63a5\u53d7\u8fc7BCMA CAR T\u7597\u6cd5\u7684\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u4fe1\u606f\u3002\u672c\u65b0\u95fb\u7a3f\u4e2d\u5305\u542b\u7684\u9664\u5386\u53f2\u4e8b\u5b9e\u4e4b\u5916\u7684\u6240\u6709\u9648\u8ff0\uff08\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u6709\u5173\u516c\u53f8\u6218\u7565\u3001\u9884\u671f\u3001\u73b0\u91d1\u751f\u547d\u5468\u671f\u548c\u672a\u6765\u8d22\u52a1\u72b6\u51b5\u3001\u672a\u6765\u8fd0\u8425\u548c\u524d\u666f\u7684\u9648\u8ff0\uff09\u5747\u4e3a\u524d\u77bb\u6027\u9648\u8ff0\u3002\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u60a8\u53ef\u4ee5\u901a\u8fc7\u8bf8\u5982“\u76ee\u7684”\u3001“\u9884\u671f”\u3001“\u5047\u8bbe”\u3001“\u76f8\u4fe1”\u3001“\u8003\u8651”\u3001“\u7ee7\u7eed”\u3001“\u53ef\u80fd”\u3001“\u8bbe\u8ba1”\u3001“\u5e94\u6709”\u3001“\u4f30\u8ba1”\u3001“\u671f\u671b”\u3001“\u76ee\u7684”\u3001“\u6253\u7b97”\u3001“\u4e5f\u8bb8”\u3001“\u76ee\u6807”\u3001“\u8ba1\u5212”\u3001“\u5b9a\u4f4d”\u3001“\u6f5c\u529b”\u3001“\u9884\u6d4b”\u3001“\u5bfb\u6c42”\u3001“\u5e94\u8be5”\u3001“\u6307\u6807”\u3001“\u5c06”\u3001“\u4f1a”\u7b49\u672f\u8bed\u548c\u5176\u4ed6\u7c7b\u4f3c\u7684\u8868\u8fbe\u6765\u8bc6\u522b\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u8fd9\u4e9b\u8868\u8fbe\u662f\u5bf9\u672a\u6765\u4e8b\u4ef6\u548c\u672a\u6765\u8d8b\u52bf\u7684\u9884\u6d4b\u6216\u6307\u793a\uff1b\u8fd9\u4e9b\u672f\u8bed\u6216\u5176\u4ed6\u7c7b\u4f3c\u672f\u8bed\u7684\u5426\u5b9a\u5f62\u5f0f\u4ea6\u7136\u3002\u672c\u516c\u53f8\u4f5c\u51fa\u8fd9\u4e9b\u524d\u77bb\u6027\u58f0\u660e\u7684\u4f9d\u636e\u4e3b\u8981\u662f\u5176\u76ee\u524d\u5bf9\u672a\u6765\u4e8b\u4ef6\u548c\u8d22\u52a1\u8d8b\u52bf\u7684\u9884\u671f\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u63a8\u6d4b\uff0c\u516c\u53f8\u8ba4\u4e3a\u8fd9\u53ef\u80fd\u4f1a\u5f71\u54cd\u5176\u8d22\u52a1\u72b6\u51b5\u3001\u8fd0\u8425\u7ed3\u679c\u3001\u4e1a\u52a1\u6218\u7565\u548c\u8d22\u52a1\u9700\u6c42\u3002\u9274\u4e8e\u8fd9\u4e9b\u524d\u77bb\u6027\u58f0\u660e\u4e2d\u5b58\u5728\u5f88\u591a\u4e0d\u786e\u5b9a\u56e0\u7d20\uff0c\u60a8\u4e0d\u5e94\u8be5\u4f9d\u8d56\u524d\u77bb\u6027\u58f0\u660e\u6765\u9884\u6d4b\u672a\u6765\u4e8b\u4ef6\u3002\u8fd9\u4e9b\u9648\u8ff0\u53ef\u80fd\u4f1a\u53d7\u5230\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u5bfc\u81f4\u5b9e\u9645\u7ed3\u679c\u53d1\u751f\u91cd\u5927\u53d8\u5316\uff0c\u5176\u4e2d\u5305\u62ec\u836f\u7269\u5f00\u53d1\u4e2d\u56fa\u6709\u7684\u98ce\u9669\uff0c\u5982\u4e0e\u516c\u53f8\u76ee\u524d\u548c\u672a\u6765\u7684\u7814\u7a76\u548c\u5f00\u53d1\u9879\u76ee\u3001\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u542f\u52a8\u3001\u6210\u672c\u3001\u65f6\u95f4\u3001\u8fdb\u5c55\u548c\u7ed3\u679c\u6709\u5173\u7684\u98ce\u9669\uff0c\u4ee5\u53ca\u56e0\u5f53\u524d\u65b0\u51a0\u75ab\u60c5\u800c\u5f15\u53d1\u7684\u7ecf\u6d4e\u3001\u5e02\u573a\u548c\u793e\u4f1a\u6df7\u4e71\u3002\u5173\u4e8e\u53ef\u80fd\u5f71\u54cd\u516c\u53f8\u5b9e\u9645\u4e1a\u7ee9\u7684\u8be6\u7ec6\u98ce\u9669\u56e0\u7d20\uff0c\u8bf7\u53c2\u8003\u672c\u516c\u53f8\u5728\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u62a5\u544a\u4e2d\u6307\u51fa\u7684\u98ce\u9669\u56e0\u7d20\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e2021\u5e743\u670824\u65e5\u768410-K\u8868\u5e74\u5ea6\u62a5\u544a\u548c2021\u5e7411\u67088\u65e5\u768410-Q\u8868\u5b63\u5ea6\u62a5\u544a\u3002\u9664\u6cd5\u5f8b\u8981\u6c42\u5916\uff0c\u516c\u53f8\u4e0d\u627f\u62c5\u56e0\u4efb\u4f55\u539f\u56e0\u516c\u5f00\u66f4\u65b0\u4efb\u4f55\u524d\u77bb\u6027\u58f0\u660e\u7684\u4e49\u52a1\u3002<\/p>\n

Sana Biotechnology\u548cSana Biotechnology\u7684\u6807\u5fd7\u662fSana Biotechnology, Inc.\u7684\u5546\u6807\u6216\u6ce8\u518c\u5546\u6807\u3002\u6240\u6709\u5176\u4ed6\u516c\u53f8\u53ca\u5176\u4ea7\u54c1\u540d\u79f0\u53ef\u80fd\u662f\u5176\u5404\u81ea\u6240\u6709\u8005\u7684\u5546\u6807\u6216\u6ce8\u518c\u5546\u6807\u3002<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u6b64\u9879\u534f\u8bae\u5c06\u9a6f\u9e7f\u533b\u7597\u4e0e\u4fe1\u8fbe\u751f\u7269\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5df2\u88ab\u9a8c\u8bc1\u7684CAR\u7ed3\u6784\u4e0eSana\u7684\u4f53\u5185\u548c\u4f53\u5916\u5de5\u7a0b\u7ec6\u80de\u6cbb\u7597\u9879\u76ee\u8fdb\u884c\u6709\u673a\u7ed3\u5408 \u897f\u96c5\u56fe\u3001\u534e\u76db\u987f\u3001\u7f8e\u56fd\u65e7\u91d1\u5c71\u3001\u5723\u8377\u897f\u3001\u5357\u4eac\u3001\u82cf\u5dde\u548c\u4e0a\u6d772022\u5e741\u670811\u65e5 \/\u7f8e\u901a\u793e\/ — Sana Biotechnology, Inc.\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aSANA\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u521b\u9020\u548c\u63d0\u4f9b\u5de5\u7a0b\u7ec6\u80de\u836f\u7269\u7684\u516c\u53f8\uff0c\u9a6f\u9e7f\u533b\u7597\uff08“IASO 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