\u4e0a\u6d772021\u5e7412\u670815\u65e5 \/\u7f8e\u901a\u793e\/ — \u8fd1\u65e5\uff0c\u6052\u745e\u533b\u836f\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u6587\u4ef6\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684<\/b>PD-1<\/b>\u6291\u5236\u5242\u5361\u745e\u5229\u73e0\u5355\u6297<\/b>2<\/b>\u4e2a\u65b0\u9002\u5e94\u75c7\u83b7\u6279\u4e0a\u5e02<\/b>\u3002<\/p>\n
\u6b64\u6b21\u83b7\u6279\u7684\u65b0\u9002\u5e94\u75c7\u5206\u522b\u4e3a\uff1a\u8054\u5408\u7d2b\u6749\u9187\u548c\u5361\u94c2\u7528\u4e8e\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3001\u8054\u5408\u7d2b\u6749\u9187\u548c\u987a\u94c2\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f<\/b>\/<\/b>\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597<\/b>\u3002\u81f3\u6b64\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u5df2\u7ecf\u5728\u80ba\u764c\u3001\u809d\u764c\u3001\u98df\u7ba1\u764c\u3001\u9f3b\u54bd\u764c\u4ee5\u53ca\u6dcb\u5df4\u7624\u4e94\u5927\u7624\u79cd\u4e2d\u83b7\u6279<\/b>8<\/b>\u4e2a\u9002\u5e94\u75c7\uff0c<\/b>\u4e3a\u76ee\u524d\u83b7\u6279\u9002\u5e94\u75c7\u6570\u91cf\u6700\u591a\u3001\u8986\u76d6\u7624\u79cd\u6700\u5e7f\u7684\u56fd\u4ea7<\/b>PD-1<\/b>\u4ea7\u54c1<\/b>\u3002<\/p>\n
\u5de9\u56fa\u80ba\u764c\u514d\u75ab\u6cbb\u7597\u9886\u57df\u5730\u4f4d<\/b><\/p>\n
\u5b9e\u73b0<\/b>NSCLC<\/b>\u9cde\u764c\u548c\u975e\u9cde\u764c\u5168\u8986\u76d6<\/b><\/p>\n
\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u4e2d\uff0c\u9cde\u72b6NSCLC\u60a3\u8005\u5927\u7ea6\u536030%\u6bd4\u4f8b\uff0c\u65e2\u5f80\u4ec5\u6709\u5316\u7597\u65b9\u6848\u53ef\u9009\uff0c\u603b\u751f\u5b58\u671f\u5927\u7ea6\u53ea\u670910\u4e2a\u6708\u5de6\u53f3\uff0c\u4e34\u5e8a\u4e9f\u9700\u66f4\u4f18\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n
\u6b64\u6b21\u5361\u745e\u5229\u73e0\u5355\u6297\u9cde\u72b6NSCLC\u4e00\u7ebf\u6cbb\u7597\u9002\u5e94\u75c7\u7684\u83b7\u6279\uff0c\u662f\u57fa\u4e8e\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u5bf9\u7167\u3001\u53cc\u76f2\u3001\u2162\u671f\u4e34\u5e8a\u7814\u7a76 — CameL-sq\u7814\u7a76\u7684\u51fa\u8272\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u5171\u7eb3\u5165389\u4f8b\u672a\u7ecf\u6cbb\u7597\u7684\u2162B\uff5e\u2163\u671f\u9cde\u72b6NSCLC\u80ba\u764c\u60a3\u8005\uff0c\u968f\u673a\u5206\u914d\u81f3\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\uff08193\u4f8b\uff09\u548c\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7ec4\uff08196\u4f8b\uff09\u3002<\/p>\n
\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u7ecf\u72ec\u7acb\u8bc4\u5ba1\u59d4\u5458\u4f1a\u8bc4\u4f30\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u60a3\u8005\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u8fbe\u5230 8.5\u4e2a\u6708\uff0c\u800c\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7ec4\u60a3\u8005mPFS\u4ec54.9\u4e2a\u6708\uff0c\u60a3\u8005\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u4e0b\u964d63%\uff08HR=0.37\uff0c95%CI 0.29\uff5e0.47\uff0c\u5355\u4fa7P\uff1c0.0001\uff09\u3002\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u540c\u6837\u5e26\u6765\u4e86\u603b\u751f\u5b58\u671f\uff08OS\uff09\u7684\u663e\u8457\u6539\u5584\uff0c\u4e24\u7ec4\u4e2d\u4f4dOS\u5206\u522b\u4e3a\u672a\u8fbe\u5230\u548c14.5\u4e2a\u6708\uff08HR=0.55\uff0c95%CI 0.40\uff5e0.75\uff0c\u5355\u4fa7P\uff1c0.0001\uff0c\u5df2\u8fbe\u5230\u7edf\u8ba1\u5b66\u5dee\u5f02\uff09\uff0c\u60a3\u8005\u6b7b\u4ea1\u98ce\u9669\u4e0b\u964d45%\u3002\u6b64\u5916\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u8fd8\u663e\u8457\u63d0\u9ad8\u6cbb\u7597\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff0c64.8% vs 36.7%\uff09\u3002\u5b89\u5168\u6027\u65b9\u9762\uff0c\u4e24\u7ec4\u22653\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u76f8\u5f53\uff0873.6% vs 71.9%\uff09\uff0c\u672a\u89c2\u5bdf\u5230\u610f\u6599\u4e4b\u5916\u7684\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n
\u5728\u9cde\u72b6NSCLC\u9886\u57df\u7684CameL-sq\u7814\u7a76\u548c\u975e\u9cde\u72b6NSCLC\u9886\u57df\u7684CameL\u7814\u7a76\u4e2d\u5747\u53ef\u4ee5\u89c2\u5bdf\u5230\uff0c\u5728\u4e3b\u8981\u7597\u6548\u6307\u6807ORR\u3001PFS\u548cOS\u4e0a\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u5747\u8868\u73b0\u51fa\u4e86\u66f4\u52a0\u5f3a\u6548\u7684\u514d\u75ab\u6cbb\u7597\u4f5c\u7528\u673a\u5236\u7279\u70b9\u3002\u8bc4\u4ef7\u514d\u75ab\u8054\u5408\u5316\u7597\u7684\u534f\u540c\u4f5c\u7528\u65f6\u8fd8\u9700\u8981\u5173\u6ce8\u8054\u5408\u6cbb\u7597\u7684\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\uff0c\u5728\u975e\u9cde\u72b6NSCLC\u4e2d\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u4e2d\u4f4dDoR\u8fbe17.6\u4e2a\u6708\uff0c\u9cde\u72b6NSCLC\u4e2d\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u4e2d\u4f4dDoR\u8fbe13.1\u4e2a\u6708\u3002<\/p>\n
CameL-sq\u548cCameL\u7814\u7a76\u7684\u6210\u529f\u4ee5\u53ca\u76f8\u5173\u9002\u5e94\u75c7\u83b7\u6279\uff0c\u6807\u5fd7\u7740\u5361\u745e\u5229\u73e0\u5355\u6297\u5728NSCLC\u9886\u57df\u5b8c\u6210\u4e86NSCLC\u9cde\u764c\u548c\u975e\u9cde\u764c\u7684\u5168\u8986\u76d6\uff0c\u8fdb\u4e00\u6b65\u592f\u5b9e\u4e86\u5176\u5728\u80ba\u764c\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u5730\u4f4d\u3002<\/p>\n
\u5b8c\u6210\u98df\u7ba1\u9cde\u764c\u4e8c\u7ebf\u5411\u4e00\u7ebf\u6cbb\u7597\u65b0\u8fc8\u8fdb<\/b><\/p>\n
\u5c06\u4e3a\u66f4\u591a\u60a3\u8005\u5e26\u6765\u751f\u5b58\u83b7\u76ca<\/b><\/p>\n
\u98df\u7ba1\u764c\u662f\u4e2d\u56fd\u9ad8\u53d1\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\uff0c2020\u5e74\u6211\u56fd\u65b0\u53d1\u75c5\u4f8b\u548c\u6b7b\u4ea1\u75c5\u4f8b\u7ea6\u5360\u5168\u7403\u4e00\u534a\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u6211\u56fd70%\u7684\u98df\u7ba1\u764c\u60a3\u8005\u786e\u8bca\u4fbf\u662f\u4e2d\u665a\u671f\uff0c5\u5e74\u751f\u5b58\u7387\u4e0d\u8db320%\u3002\u591a\u5e74\u6765\uff0c\u4e2d\u56fd\u5b66\u8005\u5728\u98df\u7ba1\u764c\u9886\u57df\u6b65\u5c65\u4e0d\u505c\uff0c\u6210\u679c\u663e\u8457\u3002<\/p>\n
\u6b64\u6b21\u5361\u745e\u5229\u73e0\u5355\u6297\u98df\u7ba1\u9cde\u764c\u4e00\u7ebf\u6cbb\u7597\u9002\u5e94\u75c7\u7684\u83b7\u6279\uff0c\u662f\u57fa\u4e8e\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u53cc\u76f2\u3001III\u671f\u4e34\u5e8a\u7814\u7a76 — ESCORT-1st\u7814\u7a76\u7684\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u7531\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f90\u745e\u534e\u6559\u6388\u56e2\u961f\u7275\u5934\uff0c\u662f\u5168\u7403\u9996\u4e2aPD-1\u5355\u6297\u8054\u5408\u7d2b\u6749\u9187\u548c\u987a\u94c2\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u98df\u7ba1\u9cde\u764c\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u5171\u7eb3\u5165596\u4f8b\u53d7\u8bd5\u8005\uff0c\u6309\u71671:1\u968f\u673a\u5206\u7ec4\uff0c\u5206\u522b\u63a5\u53d7\u5361\u745e\u5229\u73e0\u5355\u6297+\u7d2b\u6749\u9187+\u987a\u94c2\u6216\u5b89\u6170\u5242+\u7d2b\u6749\u9187+\u987a\u94c2\u6cbb\u7597\u3002\u7ed3\u679c\u663e\u793a\uff0c\u76f8\u8f83\u4e8e\u5bf9\u7167\u7ec4\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u53ef\u663e\u8457\u5ef6\u957f\u665a\u671f\u98df\u7ba1\u764c\u60a3\u8005\u7684\u4e2d\u4f4dOS\uff0815.3\u4e2a\u6708 vs 12.0\u4e2a\u6708\uff09\u548c\u4e2d\u4f4dPFS\uff086.9\u4e2a\u6708 vs 5.6\u4e2a\u6708\uff09\uff0c\u6539\u5584ORR\uff0872.1% vs 62.1%\uff09\u548c\u4e2d\u4f4dDoR\uff087.0\u4e2a\u6708 vs 4.6\u4e2a\u6708\uff09\u3002<\/p>\n
\u57fa\u4e8e\u51fa\u8272\u7684\u6570\u636e\uff0cESCORT-1st\u7814\u7a76\u8363\u767b2021\u5e74ASCO\u5927\u4f1a\u53e3\u5934\u62a5\u544a\uff0c\u540c\u65f6\u88ab\u56fd\u9645\u6743\u5a01\u6742\u5fd7\u3001\u56db\u5927\u533b\u5b66\u671f\u520a\u4e4b\u4e00\u7684\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\u300b\uff08JAMA\uff09\u5168\u6587\u5728\u7ebf\u53d1\u8868\uff0c\u6210\u4e3a\u5168\u7403\u9996\u9879\u4e5f\u662f\u552f\u4e00\u4e00\u9879\u767b\u4e0a<\/b>JAMA<\/b>\u6742\u5fd7\u7684\u98df\u7ba1\u764c\u514d\u75ab\u6cbb\u7597\u4e34\u5e8a\u7814\u7a76<\/b>\u30022021\u65b0\u7248\u300a\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u98df\u7ba1\u764c\u8bca\u7597\u6307\u5357\u300b\u4e5f\u5c06\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u7d2b\u6749\u9187\u548c\u987a\u94c2\u5316\u7597\u5217\u4e3a\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u63a8\u8350\uff08II\u7ea7\u4e13\u5bb6\u63a8\u8350\uff0c1A\u7c7b\u8bc1\u636e\uff09\uff0cESCORT-1st\u7814\u7a76\u6210\u679c\u5f97\u5230\u56fd\u5185\u5916\u5b66\u672f\u754c\u7684\u5e7f\u6cdb\u8ba4\u53ef\u3002<\/p>\n
2019\u5e74\uff0c\u98df\u7ba1\u764c\u514d\u75ab\u6cbb\u7597\u9886\u57df\u91cc\u7a0b\u7891\u5f0f\u7814\u7a76<\/span> — ESCORT\u7814\u7a76\u53d6\u5f97\u7a81\u7834\u6027\u6210\u529f\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u56e0\u6b64\u83b7\u6279\u98df\u7ba1\u9cde\u764c\u4e8c\u7ebf\u6cbb\u7597\u9002\u5e94\u75c7\u3002\u6b64\u6b21\u98df\u7ba1\u9cde\u764c\u4e00\u7ebf\u6cbb\u7597\u9002\u5e94\u75c7\u7684\u83b7\u6279\uff0c\u6807\u5fd7\u7740\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u7d2b\u6749\u9187\u548c\u987a\u94c2\u5316\u7597\u6b63\u5f0f\u6210\u4e3a\u665a\u671f\u98df\u7ba1\u9cde\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u65b0\u6807\u51c6\u65b9\u6848\uff0c\u4e5f\u610f\u5473\u7740\u5361\u745e\u5229\u73e0\u5355\u6297\u5728\u665a\u671f\u98df\u7ba1\u9cde\u764c\u6cbb\u7597\u4e2d\u5b8c\u6210\u4e86\u540e\u7ebf\u6cbb\u7597\u5230\u4e00\u7ebf\u6cbb\u7597\u7684\u65b0\u8fc8\u8fdb\uff0c\u5c06\u5728\u665a\u671f\u98df\u7ba1\u764c\u524d\u7ebf\u6cbb\u7597\u4e2d\u4e3a\u66f4\u591a\u60a3\u8005\u5e26\u6765\u751f\u5b58\u83b7\u76ca\u3002<\/p>\n \u5361\u745e\u5229\u73e0\u5355\u6297\u9002\u5e94\u75c7\u62d3\u5c55\u4e0d\u65ad\u7a81\u7834<\/b><\/p>\n \u9886\u8dd1\u83b7\u6279\u9002\u5e94\u75c7\u6570\u91cf\u548c\u7624\u79cd\u8986\u76d6<\/b><\/p>\n \u81ea2019\u5e745\u6708\u4e0a\u5e02\u4ee5\u6765\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u5728\u4e0d\u540c\u7624\u79cd\u4e2d\u7684\u63a2\u7d22\u5168\u9762\u5f00\u82b1\uff0c\u6377\u62a5\u9891\u4f20\u3002\u76ee\u524d\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u5df2\u7ecf\u5728\u80ba\u764c\u3001\u809d\u764c\u3001\u98df\u7ba1\u764c\u3001\u9f3b\u54bd\u764c\u548c\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u4e94\u5927\u764c\u79cd<\/b>\u4e2d\u83b7\u62798<\/b>\u4e2a<\/b>\u9002\u5e94\u75c7\uff0c\u5728\u9002\u5e94\u75c7\u83b7\u6279\u6570\u91cf\u548c\u7624\u79cd\u8986\u76d6\u4e0a\u7ee7\u7eed\u9886\u8dd1\u56fd\u4ea7PD-1\u5355\u6297\u3002<\/p>\n \u4f5c\u4e3a\u56fd\u4ea7PD-1\u5355\u6297\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u7684\u6210\u529f\u5bf9\u4e2d\u56fd\u60a3\u8005\u800c\u8a00\u66f4\u6709\u4e0d\u4e00\u6837\u7684\u610f\u4e49\uff1a\u5176\u7814\u7a76\u6570\u636e\u6765\u6e90\u4e8e\u4e2d\u56fd\u60a3\u8005\uff0c\u9002\u4e8e\u6307\u5bfc\u4e2d\u56fd\u4e34\u5e8a\u5b9e\u8df5\uff1b\u5176\u591a\u4e2a\u9002\u5e94\u75c7\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\uff0c\u4e0d\u65ad\u63d0\u5347\u514d\u75ab\u6cbb\u7597\u7684\u53ef\u53ca\u6027\u548c\u53ef\u8d1f\u62c5\u6027\u3002<\/p>\n 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\u8fd1\u65e5\uff0c\u6052\u745e\u533b\u836f\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u6587\u4ef6\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684PD-1\u6291\u5236\u5242\u5361\u745e\u5229\u73e0\u5355\u62972\u4e2a\u65b0\u9002\u5e94\u75c7\u83b7\u6279\u4e0a\u5e02\u3002 \u6b64\u6b21\u83b7\u6279\u7684\u65b0\u9002\u5e94\u75c7\u5206\u522b\u4e3a\uff1a\u8054\u5408\u7d2b\u6749\u9187\u548c\u5361\u94c2\u7528\u4e8e\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3001\u8054\u5408\u7d2b\u6749\u9187\u548c\u987a\u94c2\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\/\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u81f3\u6b64\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u5df2\u7ecf\u5728\u80ba\u764c\u3001\u809d\u764c\u3001\u98df\u7ba1\u764c\u3001\u9f3b\u54bd\u764c\u4ee5\u53ca\u6dcb\u5df4\u7624\u4e94\u5927\u7624\u79cd\u4e2d\u83b7\u62798\u4e2a\u9002\u5e94\u75c7\uff0c\u4e3a\u76ee\u524d\u83b7\u6279\u9002\u5e94\u75c7\u6570\u91cf\u6700\u591a\u3001\u8986\u76d6\u7624\u79cd\u6700\u5e7f\u7684\u56fd\u4ea7PD-1\u4ea7\u54c1\u3002 \u5de9\u56fa\u80ba\u764c\u514d\u75ab\u6cbb\u7597\u9886\u57df\u5730\u4f4d \u5b9e\u73b0NSCLC\u9cde\u764c\u548c\u975e\u9cde\u764c\u5168\u8986\u76d6 \u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u4e2d\uff0c\u9cde\u72b6NSCLC\u60a3\u8005\u5927\u7ea6\u536030%\u6bd4\u4f8b\uff0c\u65e2\u5f80\u4ec5\u6709\u5316\u7597\u65b9\u6848\u53ef\u9009\uff0c\u603b\u751f\u5b58\u671f\u5927\u7ea6\u53ea\u670910\u4e2a\u6708\u5de6\u53f3\uff0c\u4e34\u5e8a\u4e9f\u9700\u66f4\u4f18\u7684\u6cbb\u7597\u65b9\u6848\u3002 \u6b64\u6b21\u5361\u745e\u5229\u73e0\u5355\u6297\u9cde\u72b6NSCLC\u4e00\u7ebf\u6cbb\u7597\u9002\u5e94\u75c7\u7684\u83b7\u6279\uff0c\u662f\u57fa\u4e8e\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u5bf9\u7167\u3001\u53cc\u76f2\u3001\u2162\u671f\u4e34\u5e8a\u7814\u7a76 — CameL-sq\u7814\u7a76\u7684\u51fa\u8272\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u5171\u7eb3\u5165389\u4f8b\u672a\u7ecf\u6cbb\u7597\u7684\u2162B\uff5e\u2163\u671f\u9cde\u72b6NSCLC\u80ba\u764c\u60a3\u8005\uff0c\u968f\u673a\u5206\u914d\u81f3\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\uff08193\u4f8b\uff09\u548c\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7ec4\uff08196\u4f8b\uff09\u3002 \u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u7ecf\u72ec\u7acb\u8bc4\u5ba1\u59d4\u5458\u4f1a\u8bc4\u4f30\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u60a3\u8005\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u8fbe\u5230 8.5\u4e2a\u6708\uff0c\u800c\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7ec4\u60a3\u8005mPFS\u4ec54.9\u4e2a\u6708\uff0c\u60a3\u8005\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u4e0b\u964d63%\uff08HR=0.37\uff0c95%CI 0.29\uff5e0.47\uff0c\u5355\u4fa7P\uff1c0.0001\uff09\u3002\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u540c\u6837\u5e26\u6765\u4e86\u603b\u751f\u5b58\u671f\uff08OS\uff09\u7684\u663e\u8457\u6539\u5584\uff0c\u4e24\u7ec4\u4e2d\u4f4dOS\u5206\u522b\u4e3a\u672a\u8fbe\u5230\u548c14.5\u4e2a\u6708\uff08HR=0.55\uff0c95%CI 0.40\uff5e0.75\uff0c\u5355\u4fa7P\uff1c0.0001\uff0c\u5df2\u8fbe\u5230\u7edf\u8ba1\u5b66\u5dee\u5f02\uff09\uff0c\u60a3\u8005\u6b7b\u4ea1\u98ce\u9669\u4e0b\u964d45%\u3002\u6b64\u5916\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u8fd8\u663e\u8457\u63d0\u9ad8\u6cbb\u7597\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff0c64.8% vs 36.7%\uff09\u3002\u5b89\u5168\u6027\u65b9\u9762\uff0c\u4e24\u7ec4\u22653\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u76f8\u5f53\uff0873.6% vs 71.9%\uff09\uff0c\u672a\u89c2\u5bdf\u5230\u610f\u6599\u4e4b\u5916\u7684\u4e0d\u826f\u53cd\u5e94\u3002 \u5728\u9cde\u72b6NSCLC\u9886\u57df\u7684CameL-sq\u7814\u7a76\u548c\u975e\u9cde\u72b6NSCLC\u9886\u57df\u7684CameL\u7814\u7a76\u4e2d\u5747\u53ef\u4ee5\u89c2\u5bdf\u5230\uff0c\u5728\u4e3b\u8981\u7597\u6548\u6307\u6807ORR\u3001PFS\u548cOS\u4e0a\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u5747\u8868\u73b0\u51fa\u4e86\u66f4\u52a0\u5f3a\u6548\u7684\u514d\u75ab\u6cbb\u7597\u4f5c\u7528\u673a\u5236\u7279\u70b9\u3002\u8bc4\u4ef7\u514d\u75ab\u8054\u5408\u5316\u7597\u7684\u534f\u540c\u4f5c\u7528\u65f6\u8fd8\u9700\u8981\u5173\u6ce8\u8054\u5408\u6cbb\u7597\u7684\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\uff0c\u5728\u975e\u9cde\u72b6NSCLC\u4e2d\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u4e2d\u4f4dDoR\u8fbe17.6\u4e2a\u6708\uff0c\u9cde\u72b6NSCLC\u4e2d\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u4e2d\u4f4dDoR\u8fbe13.1\u4e2a\u6708\u3002 CameL-sq\u548cCameL\u7814\u7a76\u7684\u6210\u529f\u4ee5\u53ca\u76f8\u5173\u9002\u5e94\u75c7\u83b7\u6279\uff0c\u6807\u5fd7\u7740\u5361\u745e\u5229\u73e0\u5355\u6297\u5728NSCLC\u9886\u57df\u5b8c\u6210\u4e86NSCLC\u9cde\u764c\u548c\u975e\u9cde\u764c\u7684\u5168\u8986\u76d6\uff0c\u8fdb\u4e00\u6b65\u592f\u5b9e\u4e86\u5176\u5728\u80ba\u764c\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u5730\u4f4d\u3002 \u5b8c\u6210\u98df\u7ba1\u9cde\u764c\u4e8c\u7ebf\u5411\u4e00\u7ebf\u6cbb\u7597\u65b0\u8fc8\u8fdb \u5c06\u4e3a\u66f4\u591a\u60a3\u8005\u5e26\u6765\u751f\u5b58\u83b7\u76ca \u98df\u7ba1\u764c\u662f\u4e2d\u56fd\u9ad8\u53d1\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\uff0c2020\u5e74\u6211\u56fd\u65b0\u53d1\u75c5\u4f8b\u548c\u6b7b\u4ea1\u75c5\u4f8b\u7ea6\u5360\u5168\u7403\u4e00\u534a\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u6211\u56fd70%\u7684\u98df\u7ba1\u764c\u60a3\u8005\u786e\u8bca\u4fbf\u662f\u4e2d\u665a\u671f\uff0c5\u5e74\u751f\u5b58\u7387\u4e0d\u8db320%\u3002\u591a\u5e74\u6765\uff0c\u4e2d\u56fd\u5b66\u8005\u5728\u98df\u7ba1\u764c\u9886\u57df\u6b65\u5c65\u4e0d\u505c\uff0c\u6210\u679c\u663e\u8457\u3002 \u6b64\u6b21\u5361\u745e\u5229\u73e0\u5355\u6297\u98df\u7ba1\u9cde\u764c\u4e00\u7ebf\u6cbb\u7597\u9002\u5e94\u75c7\u7684\u83b7\u6279\uff0c\u662f\u57fa\u4e8e\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u53cc\u76f2\u3001III\u671f\u4e34\u5e8a\u7814\u7a76 — ESCORT-1st\u7814\u7a76\u7684\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u7531\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f90\u745e\u534e\u6559\u6388\u56e2\u961f\u7275\u5934\uff0c\u662f\u5168\u7403\u9996\u4e2aPD-1\u5355\u6297\u8054\u5408\u7d2b\u6749\u9187\u548c\u987a\u94c2\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u98df\u7ba1\u9cde\u764c\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u5171\u7eb3\u5165596\u4f8b\u53d7\u8bd5\u8005\uff0c\u6309\u71671:1\u968f\u673a\u5206\u7ec4\uff0c\u5206\u522b\u63a5\u53d7\u5361\u745e\u5229\u73e0\u5355\u6297+\u7d2b\u6749\u9187+\u987a\u94c2\u6216\u5b89\u6170\u5242+\u7d2b\u6749\u9187+\u987a\u94c2\u6cbb\u7597\u3002\u7ed3\u679c\u663e\u793a\uff0c\u76f8\u8f83\u4e8e\u5bf9\u7167\u7ec4\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u53ef\u663e\u8457\u5ef6\u957f\u665a\u671f\u98df\u7ba1\u764c\u60a3\u8005\u7684\u4e2d\u4f4dOS\uff0815.3\u4e2a\u6708 vs 12.0\u4e2a\u6708\uff09\u548c\u4e2d\u4f4dPFS\uff086.9\u4e2a\u6708 vs 5.6\u4e2a\u6708\uff09\uff0c\u6539\u5584ORR\uff0872.1% vs 62.1%\uff09\u548c\u4e2d\u4f4dDoR\uff087.0\u4e2a\u6708 vs 4.6\u4e2a\u6708\uff09\u3002 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