{"id":56537,"date":"2021-12-14T19:45:00","date_gmt":"2021-12-14T12:45:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021121419450056537"},"modified":"2021-12-15T17:55:23","modified_gmt":"2021-12-15T09:55:23","slug":"%e5%a4%a9%e6%bc%94%e8%8d%af%e4%b8%9a%e5%85%ac%e5%b8%83%e4%b8%b4%e5%ba%8a%e5%89%8d%e6%95%b0%e6%8d%ae%ef%bc%8c%e5%b1%95%e7%a4%ba%e5%85%b6adg153%e5%8f%8aadg152%e5%b7%ae%e5%bc%82%e5%8c%96%e4%bc%98","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021121419450056537","title":{"rendered":"\u5929\u6f14\u836f\u4e1a\u516c\u5e03\u4e34\u5e8a\u524d\u6570\u636e\uff0c\u5c55\u793a\u5176ADG153\u53caADG152\u5dee\u5f02\u5316\u4f18\u52bf"},"content":{"rendered":"<p><p><span class=\"xn-subheadline\">&#8211; \u5c55\u793a\u6d77\u62a5\u5728\u7b2c63\u5c4a \u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\u5e74\u4f1a\u671f\u95f4\u63a8\u51fa-<\/span><\/p>\n<p>\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u5723\u5730\u4e9a\u54e52021\u5e7412\u670814\u65e5 \/\u7f8e\u901a\u793e\/ &#8212;&nbsp; \u5929\u6f14\u836f\u4e1a\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u516c\u53f8\u201d\u6216\u201c\u5929\u6f14\u201d\uff09\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aADAG\uff09\u662f\u4e00\u5bb6\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u5e76\u5f00\u53d1\u4ee5\u539f\u521b\u6297\u4f53\u4e3a\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u3002\u516c\u53f8\u4eca\u65e5\u5ba3\u5e03\uff0c\u4e8e2021\u5e7412\u670811\u65e5\u81f314\u65e5\u53ec\u5f00\u7684\u7b2c63\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u58c1\u62a5\u5c55\u793a\u73af\u8282\u4e2d\uff0c\u5929\u6f14\u516c\u5e03\u4e86\u4e24\u6b3e\u4ea7\u54c1 &#8212; \u6297CD47\u5355\u514b\u9686\u6297\u4f53ADG153\u4e0e\u6297CD20xCD3\u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u63a5\u5408\u5668\uff08TCE\uff09ADG152\u7684\u4e34\u5e8a\u524d\u6570\u636e\uff0c\u5145\u5206\u5c55\u793a\u4e86\u5176\u663e\u8457\u7684\u4e34\u5e8a\u524d\u5dee\u5f02\u5316\u4f18<span id=\"spanHghltecd9\">\u52bf\u3002<\/span><\/p>\n<p>\u201c\u6211\u4eec\u521b\u65b0\u7684\u6297CD47\u6297\u4f53ADG153\u4e0eCD20xCD3 TCE\u53cc\u6297ADG152\u6210\u529f\u8fd0\u7528\u4e86\u5929\u6f14\u5b89\u5168\u6297\u4f53<span id=\"spanHghlt270f\">SAFEbody<b>&reg;<\/b><\/span>\u7cbe\u51c6\u63a9\u853d\u6280\u672f\uff0c\u65e8\u5728\u786e\u4fdd\u6297\u4f53\u7597\u6548\u7684\u540c\u65f6\u514b\u670d\u8fd9\u4e24\u4e2a\u9776\u70b9\u76ee\u524d\u9488\u5bf9\u8840\u6db2\u80bf\u7624\u4e34\u5e8a\u5f00\u53d1\u4e2d\u9047\u5230\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002\u201d\u5929\u6f14\u836f\u4e1a\u8054\u5408\u521b\u59cb\u4eba\u3001\u9996\u5e2d\u6267\u884c\u5b98\u517c\u8463\u4e8b\u957f\u7f57\u57f9\u5fd7\u535a\u58eb\u8868\u793a\uff0c\u201c\u5728\u4e34\u5e8a\u524d\u8bc4\u4f30\u4e2d\uff0c\u8fd9\u4e24\u6b3e\u6765\u81ea\u5929\u6f14\u53d8\u9769\u6027\u521b\u65b0\u4ea7\u54c1\u7ba1\u7ebf\u7684\u6297\u4f53\u5145\u5206\u5c55\u73b0\u51fa\u7406\u60f3\u7684\u76ee\u6807\u4ea7\u54c1\u7279\u5f81<span id=\"spanHghlt7252\">\u3002<\/span>\u4f7f\u6211\u4eec\u611f\u5230\u5174\u594b\u7684\u662fIgG1\u4e9a\u578b\u7684\u6297CD47\u5b89\u5168\u6297\u4f53<span id=\"spanHghltb0de\">SAFEbody<b>&reg;<\/b>\uff0c<\/span>\u5b83\u4e0d\u4ec5\u5c55\u73b0\u4e86IgG1\u4ecb\u5bfc\u7684\u5f3a\u5927\u80bf\u7624\u6740\u4f24\u4f5c\u7528\uff0c\u540c\u65f6\u5177\u5907\u975e\u5e38\u597d\u7684\u5b89\u5168\u6027\u548c8\u500d\u5ef6\u957f\u7684\u534a\u8870\u671f\u3002\u800c\u7b2c\u4e00\u6b3e\u53cc\u6297\u5f3a\u529b\u6297\u4f53POWERbody CD20xCD3 TCE\uff0c\u62e5\u6709\u6211\u4eec\u91cf\u8eab\u6253\u9020\u5177\u6709\u7cbe\u786e\u63a9\u853d\u6027\u7684\u6297CD3\u7ed3\u5408\u81c2\uff0c<span id=\"spanHghlt6ac8\">\u5728\u548c\u4e00\u4e34\u5e8a\u53c2\u8003\u6297\u4f53\u5bf9\u6bd4\u8bd5\u9a8c\u4e0a<\/span>\uff0c\u6301\u7eed\u6709\u6548\u6740\u4f24\u80bf\u7624\u7684\u540c\u65f6\uff0c\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u5f31100\u500d\uff0c\u534a\u8870\u671f\u5ef6\u957f2-3\u500d\u3002\u8fd9\u4e24\u6b3e\u4ea7\u54c1\u5f70\u663e\u4e86\u5929\u6f14\u57fa\u4e8eAI\u6784\u5efa\u7684\u5f3a\u5927\u6297\u4f53\u6280\u672f\u5e73\u53f0\uff0c\u5c06\u7ee7\u7eed\u52a9\u63a8\u6211\u4eec\u7684\u7ba1\u7ebf\u8fce\u6765\u65b0\u4e00\u8f6e\u7206\u53d1\u6027\u7684\u589e\u957f\u3002\u201d<\/p>\n<p><b>ADG153 <\/b>\uff08\u65b0\u578b\u6297&nbsp;CD47 \u5355\u514b\u9686\u5b89\u5168\u6297\u4f53\uff09<\/p>\n<p>\u6807\u9898\uff1aADG153\uff0c\u65b0\u578b\u6297CD47\u5355\u514b\u9686\u5b89\u5168\u6297\u4f53\u5bf9\u6807\u53c2\u8003\u4e34\u5e8a\u6297\u4f53\uff1a\u66f4\u5f3a\u7684\u4f53\u5185\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u66f4\u957f\u7684\u534a\u8870\u671f\uff0c\u6700\u5c11\u7684\u7ea2\u7ec6\u80de\u6bd2\u6027\u4e0eCD47\u6297\u539f\u6c89\u9ed8<\/p>\n<p>\u5c55\u793a\u7f16\u53f7\uff1a3342<\/p>\n<p>\u91cd\u8981\u6570\u636e\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u9488\u5bf9\u5f53\u524d\u6297CD47\u6297\u4f53\u4e34\u5e8a\u5f00\u53d1\u4e2d\u4ea7\u751f\u7684\u5242\u91cf\u9650\u5236\u6027\u8840\u6db2\u6bd2\u6027\u53ca\u6297\u539f\u6c89\u9ed8\u7b49\u95ee\u9898\uff0c\u5929\u6f14\u91cf\u8eab\u6253\u9020\u4e86\u8fd9\u6b3e\u5177\u6709\u7cbe\u786e\u63a9\u853d\u6027\u7684\u6297CD47\u5b89\u5168\u6297\u4f53\uff0c\u4f18\u5148\u7ed3\u5408\u5728\u80bf\u7624\u7ec6\u80de\u4e0a\u8fc7\u8868\u8fbe\u7684CD47\u800c\u4e0d\u88ab\u6b63\u5e38\u7ec6\u80de\u4e0a\u7684\u6297\u539f\u6c89\u9ed8\u3002\u6b64\u5916\uff0c\u4e3a\u4e86\u5145\u5206\u91ca\u653e\u6297CD47\u6cbb\u7597\u8840\u6db2\u80bf\u7624\u548c\u5b9e\u4f53\u6076\u6027\u80bf\u7624\u7684\u6f5c\u529b\uff0c\u5b89\u5168\u6297\u4f53\u7684\u8fd0\u7528\u4f7f\u5f97\u6211\u4eec\u53ef\u4ee5\u5229\u7528IgG1\u4ecb\u5bfc\u7684\u5f3a\u6548\u5e94\u529f\u80fd\u6709\u6548\u6740\u6b7b\u80bf\u7624\uff0c\u540c\u65f6\u4e5f\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u6297\u539f\u6c89\u9ed8\u548c\u7ea2\u7ec6\u80de (RBC) \u6d88\u8017\uff0c\u5e76\u5ef6\u957f\u7ea68\u500d\u7684\u534a\u8870\u671f\u4ee5\u65b9\u4fbf\u7ed9\u836f\u3002 <\/li>\n<li>\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0c\u5bf9\u6bd4ADG153-G4\u5b89\u5168\u6297\u4f53\u4e0e\u5176\u4eb2\u672c\u6297\u4f53\uff0c\u4ee5\u53caIgG4\u5f62\u5f0f\u7684Magrolimab (Hu5F9)\u548clemzoparlimab (TJC4)\u7684\u53c2<span id=\"spanHghltcaf6\">\u8003<\/span>\u6297\u4f53\uff0c\u5177\u6709\u4ee5\u4e0b\u53d1\u73b0\uff1a<\/li>\n<\/ul>\n<p id=\"indentid\" class=\"prnml40\">&#8211; ADG153-G4\u4eb2\u672c\u6297\u4f53\u53ca\u5176\u6fc0\u6d3b\u7684\u5b89\u5168\u6297\u4f53\u53ef\u4ee5\u901a\u8fc7\u9776\u5411CD47\u7684\u72ec\u7279\u8868\u4f4d\uff0c\u5728\u4fdd\u6301\u9ad8\u4eb2\u548c\u529b\u963b\u65adCD47\u4fe1\u53f7\u7684\u540c\u65f6\uff0c<span id=\"spanHghltac2f\">\u53ef\u4ee5\u6781\u5927\u5730\u51cf\u5c11\u8840\u51dd\u4f5c\u7528\u7684\u4ea7\u751f\u3002<\/span><\/p>\n<p id=\"indentid\" class=\"prnml40\">&#8211; \u5728\u7334\u5b50\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u4e0e10 mg\/kg\u7684Hu5F9\u76f8\u6bd4\uff0cADG153-G4 \u572810\u300130\u548c60 mg\/kg\u5242\u91cf\u7ec4\u51fa\u73b0\u7ea2\u7ec6\u80de\u548c\u8840\u7ea2\u86cb\u767d\u4e0b\u964d\u7684\u5e45\u5ea6\u66f4\u5c0f\uff0c\u6709\u671b\u89e3\u51b3\u5f53\u524d\u6297CD47\u7597\u6cd5\u5e38\u89c1\u7684\u8840\u6db2\u6bd2\u6027\u95ee\u9898\u3002<\/p>\n<p id=\"indentid\" class=\"prnml40\">&#8211; ADG153-G4\u5b89\u5168\u6297\u4f53\u8fd8\u514b\u670d\u4e86\u73b0\u6709\u6297CD47\u7597\u6cd5\u89c2\u5bdf\u5230\u7684\u6297\u539f\u6c89\u9ed8\u95ee\u9898\uff0c\u5176\u534a\u8870\u671f\u5ef6\u957f\u4e868\u500d\u3002<\/p>\n<p id=\"indentid\" class=\"prnml40\">&#8211; \u5bf9\u6bd4IgG4\u540c\u7c7b\u578b\u7684\u6297CD47\u6297\u4f53\uff0c\u4ec5\u62e5\u6709CD47\u4ecb\u5bfc\u7684\u5de8\u566c\u7ec6\u80de\u7684\u541e\u566c\u4f5c\u7528\u5373\u6297\u4f53\u4f9d\u8d56\u6027\u7684\u7ec6\u80de\u541e\u566c\u4f5c\u7528\u6548\u5e94(ADCP)\u3002<\/p>\n<ul type=\"disc\">\n<li>\u6297CD47 ADG153-G1\u5b89\u5168\u6297\u4f53\u65e8\u5728\u901a\u8fc7IgG1\u4ecb\u5bfc\u7684ADCC\u53caADCP\u6548\u5e94\u529f\u80fd\u6700\u5927\u9650\u5ea6\u5730\u6740\u6b7b\u80bf\u7624\uff0c\u8d85\u8d8a\u4e86\u76ee\u524d\u5728\u4e34\u5e8a\u5f00\u53d1\u4e2d\u7684\u6297CD47\u7597\u6cd5\u901a\u8fc7IgG4\u4ecb\u5bfc\u7684ADCP\u6548\u5e94\u529f\u80fd\uff1a<\/li>\n<\/ul>\n<p id=\"indentid\" class=\"prnml40\">&#8211; ADG153-G1\u53ef\u4ee5\u8bf1\u5bfc\u4ea7\u751f\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528 (ADCC) \uff0cIgG4\u4ecb\u5bfc\u7684ADG153<span id=\"spanHghlt14fb\">\u548c\u53c2\u8003\u6297\u4f53\u5219\u6ca1\u6709\u8fd9\u79cd\u6548\u679c<\/span><\/p>\n<p id=\"indentid\" class=\"prnml40\">&#8211; \u4e0e\u53c2\u8003\u6297\u4f53\u76f8\u6bd4\uff0cADG153-G1\u53ef\u8bf1\u53d1\u66f4\u5f3a\u7684\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u4ecb\u5bfc\u7684\u541e\u566c\uff08ADCC\uff09\u53caADCP\u4f5c\u7528\u3002<\/p>\n<ul type=\"disc\">\n<li>\u4e34\u5e8a\u524d\u7ed3\u679c\u8868\u660e\uff0cADG153-G1\u5b89\u5168\u6297\u4f53\u5177\u6709\u5f3a\u5927\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5e76\u4fdd\u6301\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u4e3a\u5c06\u8be5\u5019\u9009\u836f\u7269\u8fdb\u4e00\u6b65\u63a8\u5411\u4e34\u5e8a\u63d0\u4f9b\u4e86\u5f3a\u6709\u529b\u7684\u6570\u636e\u652f\u6301\u3002&nbsp;\u76ee\u524d\u5c1a\u65e0\u5176\u4ed6\u5df2\u77e5\u7684IgG1\u4e9a\u578b\u6297CD47\u6297\u4f53\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u3002<\/li>\n<\/ul>\n<p id=\"indentid\" class=\"prnml40\">&#8211; \u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cADG153-G1\u5b89\u5168\u6297\u4f53\u572810mg\/kg\u5242\u91cf\u7ec4\u4ecd\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u7ea2\u7ec6\u80de\u4ec5\u51cf\u5c11 8%\uff0c\u800cIgG4\u5f62\u5f0f\u7684Hu5F9\u5219\u51cf\u5c1149%\u3002&nbsp;\u800c\u901a\u8fc7\u53c2\u8003<a target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/bcj20177#author-information\" rel=\"nofollow noopener\"><span id=\"spanHghlt6ea6\">\u6587\u732e<\/span><\/a>\u5f97\u77e5\uff0c\u53e6\u4e00\u6b3eIgG1\u6297CD47 \u6297\u4f53\u57281mg\/kg\u5242\u91cf\u7ec4\u4f7f\u7ea2\u7ec6\u80de\u542b\u91cf\u4e0b\u964d40%\u4ee5\u4e0a\u3002<\/p>\n<p id=\"indentid\" class=\"prnml40\">&#8211; \u5355\u6b21\u9759\u8109\u7ed9\u836f\u540e\uff0cADG153-G1\u572810mg\/kg\u5242\u91cf\u7ec4\u8868\u73b0\u51fa\u6bd4Hu5F9\u957f\u7ea68\u500d\u7684\u8868\u89c2\u534a\u8870\u671f\u548c\u9ad85\u500d\u7684\u66f2\u7ebf\u4e0b\u9762\u79ef(AUC)\u3002<\/p>\n<ul type=\"disc\">\n<li>\u7efc\u4e0a\u6240\u8ff0\uff0c\u4e34\u5e8a\u524d\u7814\u7a76\u7ed3\u679c\u8868\u660eADG153-G1\u5b89\u5168\u6297\u4f53\u96c6\u5b89\u5168\u6027\uff08\u7cbe\u786e\u63a9\u853d\u6280\u672f\uff09\u548c\u6709\u6548\u6027\uff08IgG1\u4ecb\u5bfc\u7684ADCC\u548cADCP\uff09\u4e8e\u4e00\u4f53\uff0c\u6709\u671b\u6700\u5927\u9650\u5ea6\u5730\u53d1\u6325\u6297CD47\u7597\u6cd5\u6cbb\u7597\u5b9e\u4f53\u6076\u6027\u80bf\u7624\u7684\u6f5c\u529b\u3002<\/li>\n<\/ul>\n<p><b>ADG152 (CD20xCD3<\/b><b>\u53cc\u7279\u5f02\u6027\u5f3a\u529b\u6297\u4f53POWERbody<sup>TM<\/sup><\/b><b>)<\/b><\/p>\n<p>\u6807\u9898\uff1aADG152\uff0c\u65b0\u578bCD20xCD3\u53cc\u7279\u5f02\u6027\u5b89\u5168\u6297\u4f53\u5c55\u73b0\u51fa\u5f3a\u5927\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u66f4\u9ad8\u7684\u5b89\u5168\u6027<\/p>\n<p>\u5c55\u793a\u7f16\u53f7\uff1a1204<\/p>\n<p>\u91cd\u8981\u6570\u636e\uff1a<\/p>\n<ul type=\"disc\">\n<li>ADG152\u662f\u4e00\u79cd\u53cc\u7279\u5f02\u6027CD20xCD3 T\u7ec6\u80de\u63a5\u5408\u5668\u5f3a\u529b\u6297\u4f53POWERbody<sup>TM<\/sup>\uff0c\u5e76\u878d\u5408\u4e86\u5b89\u5168\u6297\u4f53<span id=\"spanHghlt569f\">SAFEbody<sup>&reg;<\/sup><\/span>\u7cbe\u51c6\u63a9\u853d\u6280\u672f\uff0c\u53ef\u6700\u5927\u9650\u5ea6\u5730\u6291\u5236\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u75c7\uff08CRS\uff09\u4ee5\u53ca\u964d\u4f4e\u7ed3\u5408\u975e\u80bf\u7624\u7ec4\u7ec7\u91cc\u7684\u9776\u6807\u800c\u4ea7\u751f\u7684\u6bd2\u6027\uff0c\u4ece\u800c\u63d0\u5347\u6cbb\u7597\u6307\u6570\u3002<\/li>\n<\/ul>\n<p id=\"indentid\" class=\"prnml40\">&#8211; ADG152\u7684\u6297CD20\u7ed3\u5408\u81c2\u53ef\u63d0\u5347\u4e0eCD20\u7684\u7ed3\u5408\u529b\uff0c\u6297CD3\u7ed3\u5408\u81c2\u5219\u662f\u91cf\u8eab\u6253\u9020\uff0c\u5177\u6709\u7cbe\u786e\u7684\u63a9\u853d\u6027\u3002<\/p>\n<ul type=\"disc\">\n<li>\u5728\u767e\u500d\u5242\u91cf\u5bf9\u6bd4\u8bd5\u9a8c\u4e2d\uff0c30mg\/kg\u7684ADG152\u7684\u7ec6\u80de\u56e0\u5b50\u8bf1\u5bfc\u6548\u5e94\uff08\u4ee5\u767d\u7ec6\u80de\u4ecb\u7d20-2\u4e0e\u03b3\u5e72\u6270\u7d20\u542b\u91cf\u4e3a\u6d4b\u91cf\u6307\u6807\uff09\u8fdc\u4f4e\u4e8e0.3 mg\/kg\u7684\u5e15\u62c9\u83ab\u59a5\u5355\u6297\uff08plamotamab\uff09\u53c2<span id=\"spanHghlt0cb0\">\u8003<\/span>\u6297\u4f53\u3002\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0c1.5 mg\/kg\u7684ADG152\u53ef\u8bf1\u53d1\u5242\u91cf\u4f9d\u8d56\u6027\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u51e0\u4e4e\u5b8c\u5168\u963b\u6291\u80bf\u7624\u751f\u957f\u3002 <\/li>\n<li>ADG152\u5728\u4e0d\u540c\u5242\u91cf\u6c34\u5e73\u4e0b\u8bf1\u5bfc\u5f3a\u70c8\u4e14\u6301\u7eed\u7684B\u7ec6\u80de\u8017\u7aed\u3002 <\/li>\n<li>\u5728\u7334\u5b50\u4f53\u5185\uff0cADG152\u8fd8\u5c55\u73b0\u51fa\u4f18\u4e8e\u5e15\u62c9\u83ab\u59a5\u5355\u6297\uff08plamotamab\uff09\u53c2<span id=\"spanHghlt6e2d\">\u8003<\/span>\u6297\u4f53\u7684\u836f\u7269\u4ee3\u8c22\u52a8\u529b\u5b66\u7279\u6027\uff0c\u7ecf\u8fc7\u4e00\u6b21\u9759\u8109\u6ce8\u5c04\u540e\uff0c\u534a\u8870\u671f\u5927\u7ea6\u5ef6\u957f2\u500d\uff080.3-30mg\/kg \u65f6\u4e3a7-13\u5929\uff09\uff0c\u5355\u6b21\u9759\u8109\u6ce8\u5c04\u540e\u66f2\u7ebf\u4e0b\u9762\u79ef\uff08AUC\uff09\u6269\u59278\u500d\u3002<\/li>\n<\/ul>\n<p>\u201c\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u4e00\u76f4\u662fT\u7ec6\u80de\u63a5\u5408\u5668\u81ea\u8bde\u751f\u4ee5\u6765\u6240\u9762\u4e34\u7684\u4e00\u5927\u6311\u6218\uff0c\u5b89\u5168\u6027\u7684\u8003\u91cf\u4e5f\u9650\u5236\u4e86\u7ed9\u836f\u7a7a\u95f4\uff0c\u8d77\u59cb\u5242\u91cf\u65e0\u6cd5\u8fbe\u5230\u6d3b\u6027\u6c34\u5e73\u3002\u201d\u7f8e\u56fd\u5185\u79d1\u533b\u5e08\u534f\u4f1a\u4f1a\u5458\u3001\u533b\u5b66\u535a\u58ebStanley Frankel\u5982\u662f\u8bf4\u3002Stanley Frankel \u66fe\u7ecf\u4efb\u804c\u4e8eMicromet\u53caAmgen\uff0c\u4e3ablinatumomab\uff08Blincyto&reg;\uff09\u7684\u5f00\u53d1\u548c\u6279\u51c6\u505a\u51fa\u4e86\u8d21\u732e\u3002\u4ed6\u7ee7\u7eed\u8868\u793a\uff0c\u201c\u6211\u4eec\u957f\u671f\u7f3a\u5c11\u4e00\u79cd\u80fd\u591f\u6d88\u9664CRS\u7ba1\u63a7\u590d\u6742\u6027\uff08\u5982\u5206\u6b65\u7ed9\u836f\u548c\u7c7b\u56fa\u9187\u9884\u5904\u7406\uff09\u7684\u89e3\u51b3\u65b9\u6848\u3002\u9488\u5bf9\u8fd9\u4e9b\u68d8\u624b\u95ee\u9898\uff0c&nbsp;ADG152\u7684\u4e34\u5e8a\u524d\u6570\u636e\u8ba9\u6211\u4eec\u770b\u5230\u4e86\u524d\u666f\u4e50\u89c2\u7684\u7b80\u5355\u89e3\u51b3\u65b9\u6848\u7684\u53ef\u80fd\uff0c\u5e76\u80fd\u53d1\u6325\u5f3a\u529b\u6297\u4f53\u6280\u672fPOWERbody\u5f15\u5bfcT\u7ec6\u80de\u653b\u51fb\u80bf\u7624\u7ec4\u7ec7\u7684\u529f\u6548\u3002\u201d<\/p>\n<p>\u76ee\u524d\u5929\u6f14\u7ee7\u7eed\u6269\u5927\u548c\u63a8\u8fdb\u521b\u65b0\u7684\u4e34\u5e8a\u524d\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ecADG152\u4e0eADG153\u5728\u5185\uff0c\u5df2\u6709\u4e94\u4e2a\u9879\u76ee\u6b63\u5904\u4e8e\u65b0\u836f\u7533\u8bf7\u7684<span id=\"spanHghlt8079\">\u4e34\u5e8a\u524d\u7814\u7a76\uff08IND-enabling\uff09\u9636\u6bb5\u3002<\/span>\u5728ASH\u5e74\u4f1a\u671f\u95f4\u516c\u5e03\u7684\u4e34\u5e8a\u524d\u6570\u636e\u4e3a\u8fd9\u4e9b\u6f5c\u5728\u7684\u540c\u7c7b\u6700\u4f73\u5019\u9009\u836f\u7269\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u63d0\u4f9b\u4e86\u575a\u5b9e\u4f9d\u636e\u3002<\/p>\n<p>\u5173\u4e8e\u5929\u6f14\u836f\u4e1a<\/p>\n<p>\u5929\u6f14\u836f\u4e1a\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aADAG\uff09\u662f\u5e73\u53f0\u9a71\u52a8\u5e76\u62e5\u6709\u81ea\u4e3b\u5e73\u53f0\u4ea7\u51fa\u7684\u4e34\u5e8a\u4ea7\u54c1\u5f00\u53d1\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u516c\u53f8\u81f4\u529b\u4e8e\u53d1\u73b0\u5e76\u5f00\u53d1\u4ee5\u539f\u521b\u6297\u4f53\u4e3a\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u3002\u501f\u529b\u4e8e\u8ba1\u7b97\u751f\u7269\u5b66\u4e0e\u4eba\u5de5\u667a\u80fd\uff0c\u51ed\u501f\u5176\u5168\u7403\u9996\u521b\u7684\u4e09\u4f53\u5e73\u53f0\u6280\u672f\uff08\u65b0\u8868\u4f4d\u6297\u4f53NEObody&#x2122;\uff0c\u5b89\u5168\u6297\u4f53<span id=\"spanHghlt223b\">SAFEbody<\/span>&reg;\u53ca\u5f3a\u529b\u6297\u4f53POWERbody&#x2122;\uff09\uff0c\u5929\u6f14\u836f\u4e1a\u5df2\u5efa\u7acb\u8d77\u805a\u7126\u4e8e\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u72ec\u7279\u539f\u521b\u7684\u6297\u4f53\u4ea7\u54c1\u7ebf\uff0c\u4ee5\u89e3\u51b3\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002\u5929\u6f14\u5df2\u548c\u591a\u4e2a\u5168\u7403\u77e5\u540d\u5408\u4f5c\u4f19\u4f34\u8fbe\u6210\u4e86\u6218\u7565\u5408\u4f5c\u5173\u7cfb\uff0c\u5e76\u4ee5\u5176\u591a\u79cd\u539f\u521b\u524d\u6cbf\u79d1\u6280\u4e3a\u5408\u4f5c\u4f19\u4f34\u7684\u65b0\u836f\u7814\u53d1\u8d4b\u80fd\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\uff1a<a target=\"_blank\" href=\"https:\/\/investor.adagene.com\/\" rel=\"nofollow noopener\">https:\/\/investor.adagene.com<\/a>\u3002<\/p>\n<p><span id=\"spanHghlt2048\">SAFEbody&reg;<\/span>\u662f\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u65e5\u672c\u3001\u65b0\u52a0\u5761\u548c\u6b27\u76df\u7684\u6ce8\u518c\u5546\u6807\u3002<\/p>\n<p>\u5b89\u5168\u6e2f\u58f0\u660e<\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u5305\u62ec\u5173\u4e8e\u4e34\u5e8a\u524d\u6570\u636e\u7684\u6f5c\u5728\u5f71\u54cd\u7684\u9648\u8ff0\uff0c\u4ee5\u53ca\u5929\u6f14\u836f\u4e1a\u5bf9\u5176\u5019\u9009\u4ea7\u54c1\u7684\u4e34\u5e8a\u5f00\u53d1\u3001\u76d1\u7ba1\u91cc\u7a0b\u7891\u3002\u7531\u4e8e\u5404\u79cd\u91cd\u8981\u56e0\u7d20\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u9648\u8ff0\u4e2d\u6240\u793a\u7684\u7ed3\u679c\u5b58\u5728\u91cd\u5927\u5dee\u5f02\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u5929\u6f14\u836f\u4e1a\u8bc1\u660e\u5176\u5019\u9009\u836f\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff1b\u5176\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u7ed3\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u8fdb\u4e00\u6b65\u5f00\u53d1\u6216\u76d1\u7ba1\u6279\u51c6\uff1b\u76f8\u5173\u76d1\u7ba1\u673a\u6784\u5c31\u5929\u6f14\u836f\u4e1a\u5019\u9009\u836f\u7269\u7684\u76d1\u7ba1\u6279\u51c6\u505a\u51fa\u51b3\u5b9a\u7684\u5185\u5bb9\u548c\u65f6\u95f4\uff1b\u5982\u679c\u83b7\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u836f\u4e1a\u4e3a\u5176\u5019\u9009\u836f\u7269\u53d6\u5f97\u5546\u4e1a\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u836f\u4e1a\u4e3a\u5176\u6280\u672f\u548c\u836f\u7269\u83b7\u5f97\u548c\u7ef4\u6301\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u7684\u80fd\u529b\uff1b\u5929\u6f14\u836f\u4e1a\u4f9d\u8d56\u7b2c\u4e09\u65b9\u8fdb\u884c\u836f\u7269\u5f00\u53d1\u3001\u5236\u9020\u548c\u5176\u4ed6\u670d\u52a1\uff1b\u5929\u6f14\u836f\u4e1a\u6709\u9650\u7684\u7ecf\u8425\u5386\u53f2\u4ee5\u53ca\u5929\u6f14\u836f\u4e1a\u83b7\u5f97\u989d\u5916\u8d44\u91d1\u7528\u4e8e\u8fd0\u8425\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9009\u836f\u7269\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u836f\u4e1a\u5728\u5176\u73b0\u6709\u6218\u7565\u4f19\u4f34\u5173\u7cfb\u6216\u5408\u4f5c\u4e4b\u5916\u7b7e\u8ba2\u989d\u5916\u5408\u4f5c\u534f\u8bae\u7684\u80fd\u529b\uff1bCOVID-19\u5bf9\u5929\u6f14\u836f\u4e1a\u4e34\u5e8a\u5f00\u53d1\u3001\u5546\u4e1a\u548c\u5176\u4ed6\u8fd0\u8425\u7684\u5f71\u54cd\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u836f\u4e1a\u63d0\u4ea4\u7ed9\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u7684\u6587\u4ef6\u201c\u98ce\u9669\u56e0\u7d20\u201d\u90e8\u5206\u66f4\u5145\u5206\u8ba8\u8bba\u7684\u90a3\u4e9b\u98ce\u9669\u3002\u6240\u6709\u524d\u77bb\u6027\u9648\u8ff0\u5747\u57fa\u4e8e\u5929\u6f14\u836f\u4e1a\u5f53\u524d\u53ef\u83b7\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u975e\u6cd5\u5f8b\u53ef\u80fd\u8981\u6c42\uff0c\u5929\u6f14\u836f\u4e1a\u4e0d\u627f\u62c5\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u5f00\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u7684\u4e49\u52a1\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8211; 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