{"id":56489,"date":"2021-12-14T11:12:00","date_gmt":"2021-12-14T04:12:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021121411120056489"},"modified":"2021-12-14T18:00:50","modified_gmt":"2021-12-14T10:00:50","slug":"%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9e%e5%9c%a8%e7%ac%ac63%e5%b1%8aash%ef%bc%88%e7%be%8e%e5%9b%bd%e8%a1%80%e6%b6%b2%e5%ad%a6%e4%bc%9a%ef%bc%89%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e7%99%be","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021121411120056489","title":{"rendered":"\u767e\u6d4e\u795e\u5dde\u5728\u7b2c63\u5c4aASH\uff08\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u767e\u60a6\u6cfd(R)\u5728SEQUOIA\u8bd5\u9a8c\u4e2d\u4f5c\u4e3a\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u4e00\u7ebf\u6cbb\u7597\u7684\u7814\u7a76\u7ed3\u679c"},"content":{"rendered":"<p class=\"prntac\"><i>\u767e\u60a6\u6cfd<\/i><i><sup>&reg;<\/sup><\/i><i>\u4f5c\u4e3a\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\uff0c\u5728\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u65b9\u9762\uff0c\u76f8\u6bd4\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u663e\u793a\u51fa\u4f18\u6548\u6027<\/i><\/p>\n<p class=\"prntac\"><i>\u5728\u9ad8\u98ce\u9669\u60a3\u8005\u4e9a\u7ec4\u4e2d\u540c\u6837\u89c2\u5bdf\u5230\u4e00\u81f4\u7684\u6709\u6548\u6027<\/i><\/p>\n<p class=\"prntac\"><i>\u5b89\u5168\u6027\u7ed3\u679c\u4e0e\u65e2\u5f80\u62a5\u544a\u7684\u7279\u5f81\u6574\u4f53\u4e00\u81f4<\/i><\/p>\n<p class=\"prntac\"><i>ASH<\/i><i>\u5ba1\u9605\u4e86\u8bd5\u9a8c\u961f\u5217<\/i><i>3<\/i><i>\uff08\u767e\u60a6\u6cfd<\/i><i><sup>&reg;<\/sup><\/i><i>\u8054\u5408\u7ef4\u5948\u514b\u62c9\u6cbb\u7597<\/i><i>17p<\/i><i>\u67d3\u8272\u4f53\u7f3a\u5931\u6216<\/i><i>TP53<\/i><i>\u57fa\u56e0\u7a81\u53d8\u60a3\u8005\uff09\u7684\u521d\u6b65\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e<\/i><\/p>\n<p><p>\u4e2d\u56fd\u5317\u4eac\u548c\u7f8e\u56fd\u9ebb\u7701\u5251\u68652021\u5e7412\u6708<span id=\"spanHghlt36d2\">14<\/span>\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u767e\u6d4e\u795e\u5dde\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1a\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff09\u662f\u4e00\u5bb6\u5168\u7403\u6027\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5728\u4e16\u754c\u8303\u56f4\u5185\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u521b\u65b0\u836f\u7269\uff0c\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u7ed3\u679c\uff0c\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u516c\u53f8\u4eca\u65e5\u516c\u5e03SEQUOIA\u8bd5\u9a8c\u7684\u671f\u4e2d\u5206\u6790\u7ed3\u679c\uff0c\u8fd9\u662f\u4e00\u9879\u5728\u521d\u6cbb\uff08TN\uff09\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u60a3\u8005\u4e2d\u8fdb\u884c\u76843\u671f\u8bd5\u9a8c\uff0c\u6b64\u6b21\u7eb3\u5165\u5206\u6790\u7684\u6570\u636e\u6765\u81ea\u5bf9\u6bd4\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u548c\u82ef\u8fbe\u83ab\u53f8\u6c40\u8054\u5408\u5229\u59a5\u6614\u5355\u6297\uff08B+R\u6cbb\u7597\u65b9\u6848\uff09\u7684\u968f\u673a\u961f\u52171\uff0c\u4ee5\u53ca\u8bc4\u4ef7\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u8054\u5408\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u4f3417p\u67d3\u8272\u4f53\u7f3a\u5931\uff08del[17p]\uff09\u548c\/\u6216\u81f4\u75c5\u6027TP53\u53d8\u5f02\u57fa\u56e0\u7684\u60a3\u8005\u7684\u961f\u52173\uff08D\u7ec4\uff09\u3002\u8fd9\u4e9b\u6570\u636e\u5728\u7b2c63\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u4e0a\u8fdb\u884c\u4e86\u4e24\u6b21\u53e3\u5934\u62a5\u544a\u3002&nbsp;<\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u8840\u6db2\u5b66\u9996\u5e2d\u533b\u5b66\u5b98\u9ec4\u851a\u5a1f\u533b\u5b66\u535a\u58eb\u8bc4\u8bba\u9053\uff1a\u201c\u5728SEQUOIA\u8fd9\u9879\u5177\u6709\u79ef\u6781\u610f\u4e49\u7684\u8bd5\u9a8c\u4e2d\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u5bf9\u6bd4\u5316\u5b66\u514d\u75ab\u7597\u6cd5\u7528\u4e8eCLL\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u65f6\u6240\u5448\u73b0\u51fa\u7684\u4f18\u6548\u6027\uff0c\u5370\u8bc1\u4e86\u9ad8\u9009\u62e9\u6027BTK\u6291\u5236\u5242\u7684\u6cbb\u7597\u524d\u666f\u3002\u8fd9\u4e9b\u5f3a\u6709\u529b\u7684\u6570\u636e\u4ee5\u53ca\u65e2\u5f80\u62a5\u544a\u76843\u671fALPINE\u8bd5\u9a8c\u7684\u7ed3\u679c\u90fd\u8fdb\u4e00\u6b65\u5de9\u56fa\u4e86\u6211\u4eec\u7684\u4fe1\u5ff5\u2014\u2014\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u80fd\u591f\u6210\u4e3aCLL\u60a3\u8005\u91cd\u8981\u7684\u6cbb\u7597\u65b0\u9009\u62e9\u3002\u201d<\/p>\n<p>\u8be5\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u6fb3\u5927\u5229\u4e9aPeter MacCallum\u764c\u75c7\u4e2d\u5fc3\u7684Constantine Tam \u6559\u6388\uff08\u5185\u5916\u5168\u79d1\u5b66\u58eb\u3001\u533b\u5b66\u535a\u58eb\uff09\u8868\u793a\uff1a\u201c\u4e0e\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u76f8\u6bd4\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\uff0c\u80fd\u4e3aCLL\u60a3\u8005\uff0c\u5305\u62ec\u643a\u5e26\u672a\u7a81\u53d8\u7684IGHV\u57fa\u56e0\u6216del\uff0811q\uff09\u7b49\u5177\u6709\u9ad8\u98ce\u9669\u7279\u5f81\u7684\u60a3\u8005\uff0c\u5e26\u6765\u66f4\u4f18\u7684PFS\u83b7\u76ca\u3002SEQUOIA\u8bd5\u9a8c\u7684\u5b89\u5168\u6027\u7ed3\u679c\u4e0e\u5176\u4ed6\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u62a5\u544a\u7684\u7ed3\u679c\u76f8\u4f3c\uff0c\u623f\u98a4\u7684\u53d1\u751f\u7387\u59cb\u7ec8\u8f83\u4f4e\u3002\u57fa\u4e8e\u8fd9\u4e9b\u7ed3\u679c\uff0c\u8bc1\u5b9e\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u8fd9\u6b3e\u9ad8\u9009\u62e9\u6027\u7684BTK\u6291\u5236\u5242\uff0c\u6709\u671b\u5e2e\u52a9CLL\u60a3\u8005\u5e26\u6765\u65e0\u9700\u5316\u7597\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d&nbsp;<\/p>\n<p>\u6709\u5173\u767e\u6d4e\u795e\u5dde\u4e34\u5e8a\u9879\u76ee\u548c\u516c\u53f8\u8fdb\u5c55\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u4eca\u5e74ASH\u5e74\u4f1a\u4e2d\u767e\u6d4e\u795e\u5dde\u7684\u865a\u62df\u5c55\u53f0\uff1a<a target=\"_blank\" href=\"http:\/\/www.beigenevirtualexperience.com\/\" rel=\"nofollow noopener\">http:\/\/www.beigenevirtualexperience.com<\/a>\u3002<\/p>\n<p><b>SEQUOIA\u961f\u52171\uff1a\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5bf9\u6bd4B+R\u6cbb\u7597\u65b9\u6848\u4e0d\u4f34\u6709del\uff0817p\uff09\u7684TN CLL\u60a3\u8005<\/b><\/p>\n<p><i>\u53e3\u5934\u62a5\u544a\uff1b\u6458\u8981#396<\/i><i>\uff1b<\/i><i>\u7b80\u8981<\/i><i>\u603b\u7ed3<\/i><i>\u8bf7<\/i><i>\u89c1<\/i><br \/><a target=\"_blank\" href=\"https:\/\/www.beigene.com\/pls\/ash2021\/sequoia\" rel=\"nofollow noopener\">https:\/\/www.beigene.com\/pls\/ash2021\/sequoia<\/a> <\/p>\n<p>SEQUOIA\u8bd5\u9a8c\u961f\u52171\u5171\u5165\u7ec4479\u4f8b\u80bf\u7624\u672a\u663e\u793adel\uff0817p\uff09\u7684TN CLL\u60a3\u8005\uff0c\u5176\u4e2d241\u4f8b\u60a3\u8005\u968f\u673a\u63a5\u53d7\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u6cbb\u7597\uff08A\u7ec4\uff09\uff0c238\u4f8b\u60a3\u8005\u968f\u673a\u63a5\u53d7B+R\u6cbb\u7597\u65b9\u6848\uff08B\u7ec4\uff09\u3002\u4e24\u7ec4\u60a3\u8005\u7279\u5f81\u5e73\u8861\uff0c\u5176\u4e2d50%\u4ee5\u4e0a\u7684\u60a3\u8005\u4e3aIGHV\u57fa\u56e0\u65e0\u7a81\u53d8\uff0c18%\u7684\u60a3\u8005\u4f34\u6709del\uff0811q\uff09\u3002del\uff0817p\uff09\u60a3\u8005\u63a5\u53d7\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u540e\u901a\u5e38\u7597\u6548\u4e0d\u4f73\uff0c\u5728\u961f\u52172\u4e2d\u88ab\u5206\u914d\u63a5\u53d7\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u6cbb\u7597\u3002\u961f\u52172\u7684<span id=\"spanHghltf063\">\u7ed3\u679c<\/span>\u5df2\u57282020\u5e74ASH\u5e74\u4f1a\u4e0a\u516c\u5e03\u3002<\/p>\n<p>SEQUOIA\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u968f\u673a\u961f\u52171\u4e2d\u57fa\u4e8e\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRC\uff09\u8bc4\u4f30\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002&nbsp;<\/p>\n<p>\u671f\u4e2d\u5206\u6790\u663e\u793a\uff0c\u572826.15\u4e2a\u6708\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u91cc\uff0c\u57fa\u4e8eIRC\u7684\u8bc4\u4f30\u7ed3\u679c\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728PFS\u65b9\u9762\u8d85\u8fc7B+R\u6cbb\u7597\u65b9\u6848\u3002\u7ed3\u679c\u5305\u62ec\uff1a&nbsp;<\/p>\n<ul type=\"disc\">\n<li>A\u7ec424\u4e2a\u6708PFS\u7387\u4e3a85.5%\uff0895% CI\uff1a80.1\uff0c89.6\uff09\uff0cB\u7ec4\u4e3a69.5%\uff0895% CI\uff1a62.4\uff0c75.5\uff09\uff0c\u98ce\u9669\u6bd4\uff08HR\uff09\u4e3a0.42\uff0895% CI\uff1a0.27\uff0c0.63\uff09\uff0c<i>p<\/i> &lt; 0.0001\uff1b <\/li>\n<li>\u5728\u5173\u952e\u60a3\u8005\u4e9a\u7ec4\u4e2d\u59cb\u7ec8\u89c2\u5bdf\u5230PFS\u83b7\u76ca\uff0c\u5305\u62ec\u4f34\u6709del\uff0811q\uff09\u3001IGHV\u72b6\u6001\u65e0\u7a81\u53d8\u3001Binet\u5206\u671f\u4e3aC\u671f\u548c\u5de8\u5927\u80bf\u5757\u7684\u60a3\u8005\uff1b <\/li>\n<li>\u603b\u751f\u5b58\u671f\uff08OS\uff09\u7ed3\u679c\u4ecd\u8f83\u4e3a\u65e9\u671f\uff0c\u572824\u4e2a\u6708\u65f6\uff0c\u4e24\u7ec4\u7684OS\u7387\u76f8\u4f3c\uff0cA\u7ec4\u4e3a94.3%\uff0895% CI\uff1a90.4\uff0c96.7\uff09\uff0cB\u7ec4\u4e3a94.6%\uff0895% CI\uff1a90.6\uff0c96.9\uff09\u3002 <\/li>\n<\/ul>\n<p>\u5b89\u5168\u6027\u5206\u6790\u7eb3\u5165\u4e86A\u7ec4240\u4f8b\u60a3\u8005\u548cB\u7ec4227\u4f8b\u63a5\u53d7\u81f3\u5c11\u4e00\u6b21\u76f8\u5e94\u6cbb\u7597\u7684\u60a3\u8005\u3002\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u5176\u5728\u5e7f\u6cdb\u7684\u4e34\u5e8a\u9879\u76ee\u4e00\u81f4\uff0c\u5305\u62ec\u8f83\u4f4e\u7684\u623f\u98a4\u53d1\u751f\u7387\u3002\u7ed3\u679c\u5305\u62ec\uff1a&nbsp;<\/p>\n<ul type=\"disc\">\n<li>A\u7ec4224\u4f8b\u60a3\u8005\uff0893.3%\uff09\u53d1\u751f\u81f3\u5c111\u4f8b\u4efb\u4f55\u7ea7\u522b\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\uff0c\u6700\u5e38\u89c1\u7684\uff08\u2265 12%\uff09\u4e3a\u632b\u4f24\uff0819.2%\uff09\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\uff0817.1%\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0815.4%\uff09\u3001\u8179\u6cfb\uff0813.8%\uff09\u548c\u5173\u8282\u75db\uff0813.3%\uff09\uff1b <\/li>\n<li>\u76f8\u6bd4\u4e4b\u4e0b\uff0cB\u7ec4\u6709218\u4f8b\u60a3\u8005\uff0896.0%\uff09\u53d1\u751f\u81f3\u5c111\u4f8b\u4efb\u4f55\u7ea7\u522b\u7684AE\uff0c\u6700\u5e38\u89c1\u7684\uff08\u2265 12%\uff09\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0856.8%\uff09\u3001\u6076\u5fc3\uff0832.6%\uff09\u3001\u53d1\u70ed\uff0826.4%\uff09\u3001\u76ae\u75b9\uff0819.4%\uff09\u3001\u8d2b\u8840\uff0818.9%\uff09\u3001\u4fbf\u79d8\uff0818.9%\uff09\u3001\u8f93\u6db2\u76f8\u5173\u53cd\u5e94\uff0818.9%\uff09\u3001\u75b2\u4e4f\uff0815.9%\uff09\u3001\u5455\u5410\uff0814.5%\uff09\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff0813.7%\uff09\u548c\u8179\u6cfb\uff0813.2%\uff09\uff1b <\/li>\n<li>A\u7ec4\u6709126\u4f8b\uff0852.5%\uff09\u60a3\u8005\u53d1\u751f\u81f3\u5c111\u4f8b\u2265 3\u7ea7AE\uff0c\u800cB\u7ec4\u6709181\u4f8b\uff0879.7%\uff09\uff0c\u4e24\u7ec4\u6700\u5e38\u89c1\u7684AE\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff08A\u7ec411.3% vs B\u7ec451.1%\uff09\u548c\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff08A\u7ec41.7% vs.B\u7ec47.0%\uff09\uff1b <\/li>\n<li>A\u7ec4\u670988\u4f8b\u60a3\u8005\uff0836.7%\uff09\u53d1\u751f\u81f3\u5c111\u4f8b\u4e25\u91cdAE\uff0c\u800cB\u7ec4\u6709113\u4f8b\u60a3\u8005\uff0849.8%\uff09\uff1b <\/li>\n<li>A\u7ec4\u5206\u522b\u670918\u4f8b\u60a3\u8005\uff087.5%\uff09\u3001111\u4f8b\u60a3\u8005\uff0846.3%\uff09\u548c20\u4f8b\u60a3\u8005\uff088.3%\uff09\u53d1\u751f\u4e86\u5bfc\u81f4\u5242\u91cf\u964d\u4f4e\u3001\u6682\u505c\u7ed9\u836f\u6216\u5ef6\u8fdf\u548c\u6cbb\u7597\u7ec8\u6b62\u7684AE\u4e8b\u4ef6\uff0c\u800cB\u7ec4\u5206\u522b\u670984\u4f8b\u60a3\u8005\uff0837.4%\uff09\u3001154\u4f8b\u60a3\u8005\uff0867.8%\uff09\u548c31\u4f8b\u60a3\u8005\uff0813.7%\uff09\u53d1\u751f\u4e0a\u8ff0\u4e8b\u4ef6\uff1b <\/li>\n<li>A\u7ec4\u670911\u4f8b\u60a3\u8005\uff084.6%\uff09\u53d1\u751f\u4e86\u81f4\u6b7b\u6027AE\uff0c\u800cB\u7ec4\u670911\u4f8b\u60a3\u8005\uff084.8%\uff09\u53d1\u751f\u4e86\u81f4\u6b7b\u6027AE\uff1b <\/li>\n<li>\u5168\u90e8\u7ea7\u522b\u7684AE\u5305\u62ec\u8d2b\u8840\uff08A\u7ec4 vs B\u7ec4\uff1a4.6% vs 19.4%\uff09\u3001\u5173\u8282\u75db\uff0813.3% vs 8.8%\uff09\u3001\u623f\u98a4\uff083.3% vs 2.6%\uff09\u3001\u51fa\u8840\uff0845.0% vs 11.0%\uff09\u3001\u8179\u6cfb\uff0813.8% vs 13.7%\uff09\u3001\u9ad8\u8840\u538b\uff0814.2% vs 10.6%\uff09\u3001\u611f\u67d3\uff0862.1% vs 55.9%\uff09\u3001\u808c\u75db\uff083.8% vs 1.3%\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0815.8% vs 56.8%\uff09\u3001\u53d1\u751f\u5176\u4ed6\u764c\u75c7\uff0812.9% vs 8.8%\uff09\u548c\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff084.6% vs 17.6%\uff09\u3002 <\/li>\n<\/ul>\n<p>\u6b64\u5916\uff0c\u8fd8\u5728ASH\u5e74\u4f1a\u4e2d\u62a5\u544a\u4e86\u5728\u5ef6\u957f\u968f\u8bbf\u671f\u7684\u60c5\u51b5\u4e0b\uff0c\u961f\u52172\uff08C\u7ec4\uff09\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5355\u836f\u6cbb\u7597\u4f34\u6709del\uff0817p\uff09\u60a3\u8005\u7684\u6709\u6548\u6027\u7ed3\u679c\u3002\u572830.5\u4e2a\u6708\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u91cc\uff0c24\u4e2a\u6708\u7684PFS\u7387\u4e3a88.9%\uff0895% CI\uff1a81.3\uff0c93.6\uff09\u3002&nbsp;<\/p>\n<p><b>SEQUOIA\u8bd5\u9a8c\u961f\u52171\u7684\u671f\u4e2d\u5206\u6790\u603b\u7ed3<\/b><\/p>\n<div>\n<table cellspacing=\"0\" cellpadding=\"0\" border=\"1\" class=\"prntblns\">\n<tbody>\n<tr>\n<td nowrap class=\"prnsbts prnsbr1 prnvab prnsbb1 prntac prnpl6 prnsbls prnpr6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>SEQUOIA<br \/><\/b><b>\u961f\u5217<\/b><b>1<br \/><\/b><b>\u6c47\u603b<\/b><\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen3\"><\/td>\n<td nowrap class=\"prnsbts prnsbr1 prnvab prnsbb1 prntac prnpl6 prnsbl1 prnpr6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u767e\u60a6\u6cfd<\/b><b><sup>&reg;<\/sup><\/b><b><br \/><\/b><b>\uff08<\/b><b>n=241<\/b><b>\uff09<\/b><\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen3\"><\/td>\n<td nowrap class=\"prnsbts prnrbrs prnvab prnsbb1 prntac prnpl6 prnsbl1 prnpr6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u82ef\u8fbe\u83ab\u53f8\u6c40<\/b><b>+<\/b><b>\u5229\u59a5\u6614\u5355\u6297<\/b><b><br \/><\/b><b>\uff08<\/b><b>n=238<\/b><b>\uff09<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" nowrap class=\"prnsbt1 prnrbrs prnvab prnsbb1 prntac prnpl6 prnsbls prnpr6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u6709\u6548\u6027\u7ed3\u679c<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\" nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u57fa\u4e8e<\/b><b>IRC<\/b><b>\u8bc4\u4f30<\/b><b><br \/>24<\/b><b>\u4e2a\u6708\u7684<\/b><b>PFS<\/b><b>\uff08\u4e3b\u8981\u7ec8\u70b9\uff09<\/b><\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen8\"><\/td>\n<td nowrap class=\"prnsbt1 prnsbr1 prnvab prnsbb1 prntac prnpl6 prnsbl1 prnpr6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>85.5% <br \/>(95% CI: 80.1, 89.6)<\/b><\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen8\"><\/td>\n<td nowrap class=\"prngen10\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>69.5% <br \/>(95% CI: 62.4, 75.5)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen8\"><\/td>\n<td colspan=\"3\" nowrap class=\"prngen10\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u98ce\u9669\u6bd4<\/b><b>=0.42<\/b><b>\uff08<\/b><b>95% CI<\/b><b>\uff1a<\/b><b>0.27<\/b><b>\uff0c<\/b><b>0.63<\/b><b>\uff09<\/b><\/span><\/p>\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u53cc\u4fa7<\/b><b><i>p<\/i><\/b><b> &lt; 0.0001<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" nowrap class=\"prnsbt1 prnrbrs prnvab prnsbb1 prnpl6 prnsbls prnpr6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u603b\u4f53\u5b89\u5168\u6027\u7ed3\u679c<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u4efb\u4f55\u7ea7\u522b\u7684AE<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">93.3%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">96.0%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u2265 3\u7ea7AE<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">52.5%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">79.7%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u4e25\u91cdAE<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">36.7%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">49.8%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u5bfc\u81f4\u5242\u91cf\u964d\u4f4e\u7684AE<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">7.5%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">37.4%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u5bfc\u81f4\u6682\u505c\u7ed9\u836f\u6216\u5ef6\u8fdf\u7684AE<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">46.3%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">67.8%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u5bfc\u81f4\u6cbb\u7597\u7ec8\u6b62\u7684AE<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">8.3%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">13.7%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u81f4\u6b7b\u6027AE<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">4.6%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">4.8%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" nowrap class=\"prnsbt1 prnrbrs prnvab prnsbb1 prntal prnpl6 prnsbls prnpr6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u5173\u6ce8\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08\u4efb\u4f55\u7ea7\u522b\uff09<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u8d2b\u8840 <\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">4.6%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">19.4%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">15.8%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">56.8%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u8840\u5c0f\u677f\u51cf\u5c11\u75c7<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">4.6%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">17.6%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u5173\u8282\u75db<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">13.3%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">8.8%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u623f\u98a4<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">3.3%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">2.6%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u51fa\u8840<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">45.0%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">11.0%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u8179\u6cfb<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">13.8%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">13.7%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u9ad8\u8840\u538b<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">14.2%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">10.6%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u611f\u67d3<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">62.1%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">55.9%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prngen7\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u808c\u75db<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen13\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">3.8%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen12\"><\/td>\n<td nowrap class=\"prngen14\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">1.3%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap class=\"prnsbt1 prnsbr1 prnvab prnsbbs prntac prnpl6 prnsbls prnpr6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u5176\u4ed6\u764c\u75c7<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen17\"><\/td>\n<td nowrap class=\"prnsbt1 prnsbr1 prnvab prnsbbs prntar prnpl6 prnsbl1 prnpr6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">12.9%<\/span><\/p>\n<\/td>\n<td nowrap class=\"prngen17\"><\/td>\n<td nowrap class=\"prnsbt1 prnrbrs prnvab prnsbbs prntar prnpl6 prnsbl1 prnpr6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">8.8%<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p><b>SEQUOIA\u8bd5\u9a8c\u961f\u52173\uff08D\u7ec4\uff09\uff1a\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u8054\u5408\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u4f34\u6709del\uff0817p\uff09\u548c\/\u6216TP53\u7a81\u53d8\u7684TN CLL\u60a3\u8005<\/b><\/p>\n<p><i>\u53e3\u5934\u62a5\u544a\uff1b\u6458\u8981<\/i><i>#67<\/i><\/p>\n<p>SEQUOIA\u8bd5\u9a8c\u7684\u961f\u52173\u65e8\u5728\u68c0\u9a8c\u5728\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u57fa\u7840\u4e0a\u589e\u52a0\u4f7f\u7528\u7ef4\u5948\u514b\u62c9\u53ef\u4fc3\u4f7f\u80bf\u7624\u53d6\u5f97\u66f4\u6df1\u5165\u7684\u7f13\u89e3\u7684\u5047\u8bbe\u3002\u57fa\u4e8e\u961f\u52172\u4e2d\u8bc1\u660e\u7684\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u961f\u52173\u8ba1\u5212\u5165\u7ec4\u7ea680\u4f8b\u80bf\u7624\u663e\u793a\u5e26\u6709del\uff0817p\uff09\u6216TP53\u7a81\u53d8\u7684TN CLL\u60a3\u8005\uff0c\u5173\u952e\u7ec8\u70b9\u4e3a\u5b89\u5168\u6027\u3001\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u3001PFS\u548c\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\u3002\u8fd9\u4e9b\u60a3\u8005\u5c06\u63a5\u53d7\u767e\u60a6\u6cfd<sup>&reg;<\/sup>160 mg\u6cbb\u7597\uff0c\u6bcf\u65e5\u4e24\u6b21\uff0c\u6301\u7eed3\u4e2a\u6708\uff0c\u968f\u540e\u63a5\u53d7\u76f8\u540c\u5242\u91cf\u7684\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u8054\u5408\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\uff0c\u5242\u91cf\u9012\u589e\u81f3400 mg\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u6301\u7eed12\u81f324\u4e2a\u5468\u671f\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u3001\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u6216\u786e\u8ba4\u68c0\u6d4b\u4e0d\u5230\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08uMRD\uff09\u3002&nbsp;<\/p>\n<p>\u8be5\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u6765\u81ea\u610f\u5927\u5229Grande Ospedale Metropolitano Niguarda\u533b\u9662\u7684Alessandra Tedeschi\u533b\u5b66\u535a\u58eb\u8bc4\u8bba\u9053\uff1a\u201c\u5728\u4f34\u6709del\uff0817p\uff09\u6216\u81f4\u75c5\u6027TP53\u53d8\u5f02\u4f53\u7684CLL\u60a3\u8005\u4e2d\uff0c\u5373\u4f7f\u5728\u4e00\u7ebf\u6cbb\u7597\u4e2d\u4e5f\u7ecf\u5e38\u89c2\u5bdf\u5230\u4e0d\u7406\u60f3\u7684\u9884\u540e\u7ed3\u679c\u3002\u867d\u7136\u961f\u52173\u7684\u968f\u8bbf\u65f6\u95f4\u76f8\u5bf9\u8f83\u77ed\uff0c\u4f46\u5728\u957f\u671f\u6cbb\u7597\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u9ad8\u7f13\u89e3\u7387\u548c\u66f4\u6df1\u7a0b\u5ea6\u7684\u7f13\u89e3\u8868\u660e\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u8054\u5408\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u8fd9\u4e9b\u9ad8\u98ce\u9669CLL\u60a3\u8005\u7684\u6f5c\u529b\u3002\u8054\u5408\u6cbb\u7597\u4f3c\u4e4e\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\u3002\u6211\u4eec\u671f\u5f85\u5728\u4f34\u6709del\uff0817p\uff09\u6216TP53\u7a81\u53d8\u7684TN CLL\u60a3\u8005\u4e2d\u8fdb\u4e00\u6b65\u8bc4\u4ef7\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u8054\u5408\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u3002<span id=\"spanHghltf40c\">\u201d<\/span><\/p>\n<p>\u622a\u81f3\u6570\u636e\u622a\u6b62\u65e5\u671f2021\u5e749\u67087\u65e5\uff0c\u961f\u52173\u5165\u7ec4\u4e8649\u4f8b\u60a3\u8005\uff0c\u5305\u62ec46\u4f8b\uff0893.9%\uff09\u96c6\u4e2d\u786e\u8ba4\u4e3adel\uff0817p\uff09\u72b6\u6001\u9633\u6027\u7684\u60a3\u8005\u548c3\u4f8b\uff086.1%\uff09\u4ec5\u6709\u81f4\u75c5\u6027TP53\u53d8\u5f02\u4f53\u7684\u60a3\u8005\u3002\u5165\u7ec4\u961f\u52173\u7684\u60a3\u8005\u8fd8\u663e\u793a\u51fa\u5176\u4ed6\u9ad8\u98ce\u9669\u6807\u5fd7\u7269\uff0c\u5305\u62ec87.8%\u7684\u60a3\u8005IGHV\u65e0\u7a81\u53d8\u300191.9%\u7684\u60a3\u8005\u5e76\u53d1TP53\u7a81\u53d8\u4ee5\u53ca83.3%\u7684\u60a3\u8005\u590d\u6742\u6838\u578b\uff08\u81f3\u5c113\u4e2a\u5f02\u5e38\uff09\u3002&nbsp;<\/p>\n<p>\u572812.0\u4e2a\u6708\u7684\u8f83\u77ed\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u65f6\uff0c\u622a\u81f3\u6570\u636e\u622a\u6b62\u65e5\u671f\uff0c\u5728\u81f3\u5c11\u8fdb\u884c\u8fc7\u4e00\u6b21\u57fa\u7ebf\u540e\u53d6\u5f97\u7f13\u89e3\u8bc4\u4ef7\u768436\u4f8b\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u4e86\u8f83\u9ad8\u7684ORR\u3002\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u521d\u6b65\u6709\u6548\u6027\u7ed3\u679c\u5305\u62ec\uff1a&nbsp;<\/p>\n<ul type=\"disc\">\n<li>\u5728\u63a5\u53d7\u8054\u5408\u6cbb\u7597\u8d85\u8fc712\u4e2a\u6708\u768414\u4f8b\u60a3\u8005\u4e2d\uff0c5\u4f8b\u60a3\u8005\uff0836%\uff09\u5728\u9aa8\u9ad3\u8bc4\u4f30\u4e2d\u8fbe\u5230\u7ecf\u786e\u8ba4\u7684\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u6216CR\u4f34\u9aa8\u9ad3\u529f\u80fd\u4e0d\u5b8c\u5168\u6062\u590d\uff08Cri\uff09\uff0c\u53e6\u59164\u4f8b\u60a3\u8005\u7b26\u5408CR\u6216CRi\u6807\u51c6\uff0c\u4f46\u7531\u4e8eCOVID-19\u75ab\u60c5\u9650\u5236\uff0c\u7ed3\u679c\u5728\u9aa8\u9ad3\u8bc4\u4f30\u4e2d\u672a\u786e\u8ba4\uff1b <\/li>\n<li>36\u4f8b\u6709\u6548\u6027\u53ef\u8bc4\u4ef7\u7684\u60a3\u8005\u7684ORR\u4e3a97.2%\uff0895% CI\uff1a85.5\uff0c99.9\uff09\uff0c\u5176\u4e2d13.9%\u7684\u60a3\u8005\u8fbe\u5230CR\u6216CRi\uff08\u6240\u6709\u53d6\u5f97CR\u6216CRi\u7684\u60a3\u8005\u63a5\u53d7\u8054\u5408\u6cbb\u7597\u8d85\u8fc712\u4e2a\u6708\uff09\u3002<\/li>\n<\/ul>\n<p>\u57287.9\u4e2a\u6708\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u91cc\uff0c\u6240\u670949\u4f8b\u5165\u7ec4\u60a3\u8005\u7684\u5b89\u5168\u6027\u7ed3\u679c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>40\u4f8b\u60a3\u8005\uff0881.6%\uff09\u53d1\u751f\u81f3\u5c111\u4f8b\u4efb\u4f55\u7ea7\u522b\u7684AE\uff0c\u6700\u5e38\u89c1\u7684\uff08\u2265 12%\uff09\u4e3a\u611f\u67d3\uff0816.3%\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0814.3%\uff09\u3001\u9752\u80bf\uff0812.2%\uff09\u3001\u8179\u6cfb\uff0812.2%\uff09\u3001\u8f7b\u5fae\u51fa\u8840\uff0812.2%\uff09\u548c\u6076\u5fc3\uff0812.2%\uff09\uff1b <\/li>\n<li>16\u4f8b\u60a3\u8005\uff0832.7%\uff09\u53d1\u751f\u81f3\u5c111\u4f8b\u2265 3\u7ea7AE\uff0c4\u4f8b\u60a3\u8005\uff088.2%\uff09\u53d1\u751f\u81f3\u5c111\u4f8b\u4e25\u91cdAE\uff1b <\/li>\n<li>\u5206\u522b\u670910\u4f8b\u60a3\u8005\uff0820.4%\uff09\u30010\u4f8b\u60a3\u8005\uff080.0%\uff09\u548c1\u4f8b\u60a3\u8005\uff082.0%\uff09\u53d1\u751f\u5bfc\u81f4\u5242\u91cf\u4e2d\u65ad\u3001\u5242\u91cf\u964d\u4f4e\u548c\u6cbb\u7597\u7ec8\u6b62\u7684AE\uff1b <\/li>\n<li>1\u4f8b\u60a3\u8005\uff082.0%\uff09\u53d1\u751f\u81f4\u6b7b\u6027AE\u3002 <\/li>\n<\/ul>\n<p>\u5728\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a13.5\u4e2a\u6708\u65f6\uff0c34\u4f8b\u63a5\u53d7\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u7684\u5b89\u5168\u6027\u7ed3\u679c\u5305\u62ec\uff1a&nbsp;<\/p>\n<ul type=\"disc\">\n<li>29\u4f8b\u60a3\u8005\uff0885.3%\uff09\u53d1\u751f\u81f3\u5c111\u4f8b\u4efb\u4f55\u7ea7\u522b\u7684AE\uff0c\u6700\u5e38\u89c1\uff08\u2265 12%\uff09\u4e3a\u611f\u67d3\uff0823.5%\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0820.6%\uff09\u3001\u8179\u6cfb\uff0814.7%\uff09\u3001\u75b2\u4e4f\uff0814.7%\uff09\u3001\u6076\u5fc3\uff0814.7%\uff09\u548c\u9752\u80bf\uff0811.8%\uff09\uff1b <\/li>\n<li>13\u4f8b\u60a3\u8005\uff0838.2%\uff09\u53d1\u751f\u81f3\u5c111\u4f8b\u2265 3\u7ea7AE\uff0c3\u4f8b\u60a3\u8005\uff088.8%\uff09\u53d1\u751f\u81f3\u5c111\u4f8b\u4e25\u91cdAE\uff1b <\/li>\n<li>10\u4f8b\u60a3\u8005\uff0829.4%\uff09\u53d1\u751f\u5bfc\u81f4\u6682\u505c\u7ed9\u836f\u7684AE\uff0c\u672a\u53d1\u751f\u5bfc\u81f4\u5242\u91cf\u964d\u4f4e\u6216\u6cbb\u7597\u7ec8\u6b62\u7684AE\u3002<\/li>\n<\/ul>\n<p><b>\u5173\u4e8eSEQUOIA\u8bd5\u9a8c<\/b><\/p>\n<p>SEQUOIA\u662f\u4e00\u9879\u968f\u673a\u3001\u591a\u4e2d\u5fc3\u3001\u5168\u7403\u6027\u76843\u671f\u8bd5\u9a8c\uff08NCT03336333\uff09\uff0c\u65e8\u5728\u8bc4\u4ef7\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5bf9\u6bd4&nbsp;B+R\u6cbb\u7597\u65b9\u6848\u7528\u4e8e\u6cbb\u7597TN CLL\u6216SLL\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u672c\u8bd5\u9a8c\u7531\u4e09\u4e2a\u961f\u5217\u7ec4\u6210:<\/p>\n<ul type=\"disc\">\n<li>\u961f\u52171\uff08n=479\uff09\uff1a\u4e0d\u4f34\u6709del\uff0817p\uff09\u7684\u60a3\u8005\uff0c\u4ee51\uff1a1\u7684\u6bd4\u4f8b\u968f\u673a\u63a5\u53d7\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\uff08n=241\uff09 \u6216B+R\u6cbb\u7597\u65b9\u6848\uff08n=238\uff09\u6cbb\u7597\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\uff1b\u4e3b\u8981\u7ec8\u70b9\u7684\u6570\u636e\u6765\u81ea\u8fd9\u4e00\u961f\u5217\uff1b <\/li>\n<li>\u961f\u52172\uff08n=110\uff09\uff1a\u4f34\u6709del\uff0817p\uff09\u7684\u60a3\u8005\uff0c\u63a5\u53d7\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5355\u836f\u6cbb\u7597\uff1b <\/li>\n<li>\u961f\u52173\uff08\u6b63\u5728\u5165\u7ec4\uff09\uff1a\u63a5\u53d7\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u8054\u5408\u7ef4\u5948\u514b\u62c9\u6cbb\u7597\u7684\u4f34\u6709del\uff0817p\uff09\u6216\u81f4\u75c5\u6027TP53\u53d8\u5f02\u4f53\u60a3\u8005\u3002<\/li>\n<\/ul>\n<p>\u56e0\u4e3a\u4f34\u6709del\uff0817p\uff09\u7684\u60a3\u8005\u4e34\u5e8a\u7ed3\u5c40\u5f80\u5f80\u4e0d\u7406\u60f3\uff0c\u4e14\u63a5\u53d7\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u540e\u7684\u7f13\u89e3\u60c5\u51b5\u8f83\u5dee\uff0c\u8fd9\u4e9b\u60a3\u8005\u672a\u88ab\u968f\u673a\u5206\u914d\u81f3B+R\u6cbb\u7597\u65b9\u6848\u7ec4\u3002\u672c\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u4e3aIRC\u8bc4\u4f30\u7684PFS\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u7814\u7a76\u8005\u8bc4\u4f30\u7684PFS\u3001IRC\u548c\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u3001\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3001\u4f34del(17p)\u60a3\u8005\u7684PFS\u548cORR\uff0c\u4ee5\u53ca\u5b89\u5168\u6027\u3002<\/p>\n<p>\u961f\u52172\uff08C\u7ec4\uff09\u5c55\u793a\u4e86\u63a5\u53d7\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5355\u836f\u6cbb\u7597\u7684\u9ad8\u98ce\u9669\u60a3\u8005\u7684\u6570\u636e\uff0c\u5e76\u5df2\u4e8e2020\u5e7412\u6708\u5728\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a&nbsp;\uff08ASH\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u3002\u57fa\u4e8e\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u7ed3\u679c\uff0c\u8be5\u4f34\u6709del\uff0817p\uff09\u60a3\u8005\u7684\u961f\u5217\u8fbe\u5230\u663e\u8457\u6709\u6548\u6027\uff0c18\u4e2a\u6708\u7684PFS\u4e3a90.6%\u3002<\/p>\n<p><b>\u5173\u4e8e\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u548c\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624<\/b><\/p>\n<p>\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u662f\u6210\u4eba\u6700\u5e38\u89c1\u7684\u767d\u8840\u75c5\uff0c2017\u5e74\u5168\u7403\u7ea6\u6709114000\u4f8b\u65b0\u53d1\u75c5\u4f8b\u3002<sup>1,2<\/sup>&nbsp;CLL\u4f1a\u5f71\u54cd\u9aa8\u9ad3\u4e2d\u7684\u767d\u7ec6\u80de\u6216\u6dcb\u5df4\u7ec6\u80de\u3002<sup>1<\/sup>\u9aa8\u9ad3\u4e2d\u764c\u7ec6\u80de\uff08\u767d\u8840\u75c5\uff09\u7684\u589e\u6b96\u4f1a\u5bfc\u81f4\u7ec6\u80de\u6297\u611f\u67d3\u548c\u6269\u6563\u81f3\u8840\u6db2\u7684\u80fd\u529b\u964d\u4f4e\uff0c\u540c\u65f6\u4fb5\u72af\u8eab\u4f53\u7684\u5176\u4ed6\u90e8\u5206\uff0c\u5305\u62ec\u6dcb\u5df4\u7ed3\u3001\u809d\u810f\u548c\u813e\u810f\u3002<sup>1,3<\/sup>&nbsp;BTK \u901a\u8def\u662f\u6076\u6027B\u7ec6\u80de\u4f20\u5bfc\u4fe1\u53f7\u7684\u91cd\u8981\u4ecb\u8d28\uff0c\u80fd\u591f\u81f4\u4f7fCLL\u7684\u53d1\u751f\u3002<sup>4<\/sup>\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09\u662f\u4e00\u79cd\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c\u4e3b\u8981\u5f71\u54cd\u514d\u75ab\u7cfb\u7edf\u4e2dB\u6dcb\u5df4\u7ec6\u80de\u3002SLL\u4e0eCLL\u76f8\u4f3c\uff0c\u4f46\u5176\u80bf\u7624\u7ec6\u80de\u4e3b\u8981\u79ef\u84c4\u4e8e\u6dcb\u5df4\u7ed3\u4e2d\u3002<sup>5<\/sup><\/p>\n<p><b>\u5173\u4e8e\u767e\u60a6\u6cfd<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09<\/b><\/p>\n<p>\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u662f\u4e00\u6b3e\u7531\u767e\u6d4e\u795e\u5dde\u79d1\u5b66\u5bb6\u81ea\u4e3b\u7814\u53d1\u7684\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u76ee\u524d\u6b63\u5728\u5168\u7403\u8fdb\u884c\u5e7f\u6cdb\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9879\u76ee\uff0c\u4f5c\u4e3a\u5355\u836f\u548c\u4e0e\u5176\u4ed6\u7597\u6cd5\u8fdb\u884c\u8054\u5408\u7528\u836f\u6cbb\u7597\u591a\u79cdB\u7ec6\u80de\u6076\u6027\u80bf\u7624\u3002\u7531\u4e8e\u65b0\u7684BTK\u4f1a\u5728\u4eba\u4f53\u5185\u4e0d\u65ad\u5408\u6210\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u7684\u8bbe\u8ba1\u901a\u8fc7\u4f18\u5316\u751f\u7269\u5229\u7528\u5ea6\u3001\u534a\u8870\u671f\u548c\u9009\u62e9\u6027\uff0c\u5b9e\u73b0\u5bf9BTK\u86cb\u767d\u5b8c\u5168\u3001\u6301\u7eed\u7684\u6291\u5236\u3002\u51ed\u501f\u4e0e\u5176\u4ed6\u83b7\u6279BTK\u6291\u5236\u5242\u5b58\u5728\u5dee\u5f02\u5316\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u80fd\u5728\u591a\u4e2a\u75be\u75c5\u76f8\u5173\u7ec4\u7ec7\u4e2d\u6291\u5236\u6076\u6027B\u7ec6\u80de\u589e\u6b96\u3002<\/p>\n<p>\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5df2\u572840\u4e2a\u56fd\u5bb6\u53ca\u5730\u533a\u4e2d\u83b7\u5f9712\u9879\u6279\u51c6\uff1a&nbsp;<\/p>\n<ul type=\"disc\">\n<li>2019\u5e7411\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u9879\u7597\u6cd5\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005* <\/li>\n<li>2020\u5e746\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74MCL\u60a3\u8005** <\/li>\n<li>2020\u5e746\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09&nbsp;\u60a3\u8005** <\/li>\n<li>2021\u5e742\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u963f\u62c9\u4f2f\u8054\u5408\u914b\u957f\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027MCL\u60a3\u8005 <\/li>\n<li>2021\u5e743\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u52a0\u62ff\u5927\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u6210\u5e74\u60a3\u8005 <\/li>\n<li>2021\u5e746\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74WM\u60a3\u8005** <\/li>\n<li>2021\u5e747\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u52a0\u62ff\u5927\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74MCL\u60a3\u8005 <\/li>\n<li>2021\u5e747\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u667a\u5229\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74MCL\u60a3\u8005 <\/li>\n<li>2021\u5e748\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u5df4\u897f\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74MCL\u60a3\u8005 <\/li>\n<li>2021\u5e748\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597WM\u6210\u5e74\u60a3\u8005 <\/li>\n<li>2021\u5e749\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u6297CD20\u6cbb\u7597\u65b9\u6848\u7684\u6210\u5e74\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff08MZL\uff09\u60a3\u8005* <\/li>\n<li>2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u65b0\u52a0\u5761\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74MCL\u60a3\u8005 <\/li>\n<li>2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4ee5\u8272\u5217\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005** <\/li>\n<li>2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u6fb3\u5927\u5229\u4e9a\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74WM\u60a3\u8005\u6216\u4f5c\u4e3a\u4e0d\u9002\u5408\u63a5\u53d7\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u7684\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b <\/li>\n<li>2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u6fb3\u5927\u5229\u4e9a\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74MCL\u60a3\u8005 <\/li>\n<li>2021\u5e7410\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4fc4\u7f57\u65af\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74MCL\u60a3\u8005** <\/li>\n<li>2021\u5e7411\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u6c99\u7279\u963f\u62c9\u4f2f\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74MCL\u60a3\u8005 <\/li>\n<li>2021\u5e7411\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u6b27\u76df\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u6cbb\u7597\u6216\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\u7528\u4e8e\u4e0d\u9002\u5408\u5316\u7597\u514d\u75ab\u6cbb\u7597\u7684\u6210\u5e74WM\u60a3\u8005<\/li>\n<\/ul>\n<p>\u8fc4\u4eca\u4e3a\u6b62\uff0c\u767e\u60a6\u6cfd&reg;\u5df2\u9012\u4ea4\u8d85\u8fc720\u9879\u9488\u5bf9\u591a\u9879\u9002\u5e94\u75c7\u7684\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n<p>*\u8be5\u9879\u9002\u5e94\u75c7\u57fa\u4e8e\u603b\u7f13\u89e3\u7387\u83b7\u5f97\u52a0\u901f\u6279\u51c6\u3002\u9488\u5bf9\u8be5\u9002\u5e94\u75c7\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u9a8c\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u4e34\u5e8a\u76ca\u5904\u7684\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002<\/p>\n<p>**\u8be5\u9879\u9002\u5e94\u75c7\u83b7\u9644\u6761\u4ef6\u6279\u51c6\u3002\u9488\u5bf9\u8be5\u9002\u5e94\u75c7\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u6b63\u5728\u5f00\u5c55\u7684\u786e\u8bc1\u6027\u968f\u673a\u3001\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3002<\/p>\n<p><b>\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66<\/b><\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u6216\u4e0e\u5fd7\u540c\u9053\u5408\u7684\u5408\u4f5c\u4f19\u4f34\u643a\u624b\uff0c\u4e0d\u65ad\u63a8\u52a8\u540c\u7c7b\u6700\u4f73\u6216\u540c\u7c7b\u6700\u901f\u7684\u4e34\u5e8a\u5019\u9009\u836f\u7269\u7814\u53d1\uff0c\u81f4\u529b\u4e8e\u4e3a\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u6709\u6548\u3001\u53ef\u53ca\u4e14\u53ef\u8d1f\u62c5\u7684\u836f\u7269\u3002\u516c\u53f8\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u548c\u5f00\u53d1\u56e2\u961f\u5df2\u6709\u7ea62,750\u4eba\u4e14\u4ecd\u5728\u4e0d\u65ad\u58ee\u5927\uff0c\u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u56f4\u652f\u630190\u591a\u9879\u6b63\u5728\u8fdb\u884c\u6216\u7b79\u5907\u4e2d\u7684\u4e34\u5e8a\u7814\u7a76\u7684\u5c55\u5f00\uff0c\u5df2\u62db\u52df\u60a3\u8005\u548c\u5065\u5eb7\u53d7\u8bd5\u8005\u8d85\u8fc714,000\u4eba\u3002\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u6df1\u539a\u3001\u8bd5\u9a8c\u5e03\u5c40\u5e7f\u6cdb\uff0c\u8bd5\u9a8c\u5df2\u8986\u76d6\u5168\u7403 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Pharma\u3001Mirati Therapeutics\u3001Seagen&nbsp;\u4ee5\u53ca&nbsp;Zymeworks&nbsp;\u5728\u5185\u7684\u591a\u5bb6\u516c\u53f8\u5408\u4f5c\uff0c\u66f4\u5927\u7a0b\u5ea6\u6ee1\u8db3\u5f53\u524d\u5168\u7403\u8303\u56f4\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002\u767e\u6d4e\u795e\u5dde\u8fd8\u4e0e\u8bfa\u534e\u516c\u53f8\u8fbe\u6210\u5408\u4f5c\uff0c\u6388\u6743\u8bfa\u534e\u5728\u5317\u7f8e\u3001\u6b27\u6d32\u548c\u65e5\u672c\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u3002<\/p>\n<p><b>\u5173\u4e8e\u767e\u6d4e\u795e\u5dde<\/b><\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u662f\u4e00\u5bb6\u7acb\u8db3\u79d1\u5b66\u7684\u5168\u7403\u6027\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u521b\u65b0\u3001\u53ef\u8d1f\u62c5\u7684\u836f\u7269\uff0c\u4ee5\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u6548\u679c\u548c\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u76ee\u524d\u516c\u53f8\u5e7f\u6cdb\u7684\u836f\u7269\u7ec4\u5408\u5305\u62ec40\u591a\u6b3e\u4e34\u5e8a\u5019\u9009\u836f\u7269\u3002\u516c\u53f8\u901a\u8fc7\u52a0\u5f3a\u81ea\u4e3b\u7814\u53d1\u80fd\u529b\u548c\u5408\u4f5c\uff0c\u52a0\u901f\u63a8\u8fdb\u591a\u5143\u3001\u521b\u65b0\u7684\u836f\u7269\u7ba1\u7ebf\u5f00\u53d1\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u57282030\u5e74\u524d\u4e3a\u5168\u740320\u591a\u4ebf\u4eba\u5168\u9762\u6539\u5584\u836f\u7269\u53ef\u53ca\u6027\u3002\u767e\u6d4e\u795e\u5dde\u5728\u5168\u7403\u4e94\u5927\u6d32\u6253\u9020\u4e86&nbsp;\u4e00\u652f\u8d85\u8fc77,700\u4eba\u7684\u56e2\u961f\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee <a target=\"_blank\" href=\"http:\/\/www.beigene.com.cn\/\" rel=\"nofollow noopener\">www.beigene.com.cn<\/a>\u3002 <\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b 1995 \u5e74\u300a\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\u548c\u5176\u4ed6\u8054\u90a6\u8bc1\u5238\u6cd5\u6240\u5b9a\u4e49\u7684\u524d\u77bb\u6027\u58f0\u660e\uff0c\u8fd9\u4e9b\u58f0\u660e\u6d89\u53ca\u767e\u6d4e\u795e\u5dde\u6709\u5173SEQUOIA 3\u671f\u8bd5\u9a8c\u7684\u671f\u4e2d\u5206\u6790\u7ed3\u679c\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u7684\u6f5c\u5728\u4e34\u5e8a\u83b7\u76ca\u548c\u4f18\u52bf\uff0c\u5bf9\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u9884\u671f\u7684\u4e34\u5e8a\u5f00\u53d1\u3001\u836f\u653f\u91cc\u7a0b\u7891\u548c\u5546\u4e1a\u5316\u8fdb\u7a0b\uff0c\u4ee5\u53ca\u5728\u201c\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u201d\u548c\u201c\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66\u201d\u6807\u9898\u4e0b\u63d0\u53ca\u7684\u767e\u6d4e\u795e\u5dde\u7684\u8ba1\u5212\u3001\u627f\u8bfa\u3001\u62b1\u8d1f\u548c\u76ee\u6807\u3002\u7531\u4e8e\u5404\u79cd\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u58f0\u660e\u6709\u91cd\u5927\u5dee\u5f02\u3002\u8fd9\u4e9b\u56e0\u7d20\u5305\u62ec\u4e86\u4ee5\u4e0b\u4e8b\u9879\u7684\u98ce\u9669\uff1a\u767e\u6d4e\u795e\u5dde\u8bc1\u660e\u5176\u5019\u9009\u836f\u7269\u529f\u6548\u548c\u5b89\u5168\u6027\u7684\u80fd\u529b\uff1b\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u7ed3\u679c\u53ef\u80fd\u4e0d\u652f\u6301\u8fdb\u4e00\u6b65\u5f00\u53d1\u6216\u4e0a\u5e02\u5ba1\u6279\uff1b\u836f\u653f\u90e8\u95e8\u7684\u884c\u52a8\u53ef\u80fd\u4f1a\u5f71\u54cd\u5230\u4e34\u5e8a\u8bd5\u9a8c\u7684\u542f\u52a8\u3001\u65f6\u95f4\u8868\u548c\u8fdb\u5c55\u4ee5\u53ca\u836f\u7269\u4e0a\u5e02\u5ba1\u6279\uff1b\u767e\u6d4e\u795e\u5dde\u7684\u4e0a\u5e02\u836f\u7269\u53ca\u5019\u9009\u836f\u7269\uff08\u5982\u80fd\u83b7\u6279\uff09\u83b7\u5f97\u5546\u4e1a\u6210\u529f\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u83b7\u5f97\u548c\u7ef4\u62a4\u5bf9\u5176\u836f\u7269\u548c\u6280\u672f\u7684\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u4f9d\u8d56\u7b2c\u4e09\u65b9\u8fdb\u884c\u836f\u7269\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5176\u4ed6\u670d\u52a1\u7684\u60c5\u51b5\uff1b\u767e\u6d4e\u795e\u5dde\u53d6\u5f97\u76d1\u7ba1\u5ba1\u6279\u548c\u5546\u4e1a\u5316\u533b\u836f\u4ea7\u54c1\u7684\u6709\u9650\u7ecf\u9a8c\uff0c\u53ca\u5176\u83b7\u5f97\u8fdb\u4e00\u6b65\u7684\u8425\u8fd0\u8d44\u91d1\u4ee5\u5b8c\u6210\u5019\u9009\u836f\u7269\u5f00\u53d1\u548c\u5b9e\u73b0\u5e76\u4fdd\u6301\u76c8\u5229\u7684\u80fd\u529b\uff1b\u65b0\u51a0\u80ba\u708e\u5168\u7403\u5927\u6d41\u884c\u5bf9\u767e\u6d4e\u795e\u5dde\u7684\u4e34\u5e8a\u5f00\u53d1\u3001\u76d1\u7ba1\u3001\u5546\u4e1a\u5316\u8fd0\u8425\u4ee5\u53ca\u5176\u4ed6\u4e1a\u52a1\u5e26\u6765\u7684\u5f71\u54cd\uff1b\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5728\u6700\u8fd1\u5b63\u5ea6\u62a5\u544a\u768410-Q\u8868\u683c\u4e2d\u201c\u98ce\u9669\u56e0\u7d20\u201d\u7ae0\u8282\u91cc\u66f4\u5168\u9762\u8ba8\u8bba\u7684\u5404\u7c7b\u98ce\u9669\uff1b\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u671f\u540e\u5448\u62a5\u4e2d\u5173\u4e8e\u6f5c\u5728\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8ba8\u8bba\u3002\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u4ec5\u53ca\u4e8e\u65b0\u95fb\u7a3f\u53d1\u5e03\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6d4e\u795e\u5dde\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u8be5\u7b49\u4fe1\u606f\u3002<\/p>\n<p><b>\u53c2\u8003\u6587\u732e<\/b><\/p>\n<p>1.&nbsp;&nbsp;&nbsp; American Cancer Society. Cancer Facts &amp; Figures 2021. <span class=\"xn-location\">Atlanta<\/span>; American Cancer Society; 2021. Available here: Cancer Facts and Figures 2021.<\/p>\n<p>2.&nbsp;&nbsp;&nbsp; Global Burden of Disease Cancer Collaboration. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017. JAMA Oncol. 2019;5(12):1749-1768.<\/p>\n<p>3.&nbsp;&nbsp;&nbsp; National Cancer Institute. Chronic Lymphocytic Leukemia Treatment (PDQ<sup>&reg;<\/sup>)\u2013Patient Version. Available here: Chronic Lymphocytic Leukemia Treatment (PDQ<sup>&reg;<\/sup>)\u2013Patient Version. <\/p>\n<p>4.&nbsp;&nbsp;&nbsp; Haselager MV et al. Proliferative Signals in Chronic Lymphocytic Leukemia; What Are We Missing? Front Oncol. 2020; 10: 592205.<\/p>\n<p>5.&nbsp;&nbsp;&nbsp; Cancer Support Community. Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma. Available here: <a target=\"_blank\" href=\"https:\/\/www.cancersupportcommunity.org\/chronic-lymphocytic-leukemiasmall-lymphocytic-lymphoma\" rel=\"nofollow noopener\">https:\/\/www.cancersupportcommunity.org\/chronic-lymphocytic-leukemiasmall-lymphocytic-lymphoma<\/a>.<\/p>\n<\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>http:\/\/www.beigene.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u767e\u60a6\u6cfd&reg;\u4f5c\u4e3a\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\uff0c\u5728\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u65b9\u9762\uff0c\u76f8\u6bd4\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u663e\u793a\u51fa\u4f18\u6548\u6027 \u5728\u9ad8\u98ce\u9669\u60a3\u8005\u4e9a\u7ec4\u4e2d\u540c\u6837\u89c2\u5bdf\u5230\u4e00\u81f4\u7684\u6709\u6548\u6027 \u5b89\u5168\u6027\u7ed3\u679c\u4e0e\u65e2\u5f80\u62a5\u544a\u7684\u7279\u5f81\u6574\u4f53\u4e00\u81f4 ASH\u5ba1\u9605\u4e86\u8bd5\u9a8c\u961f\u52173\uff08\u767e\u60a6\u6cfd&reg;\u8054\u5408\u7ef4\u5948\u514b\u62c9\u6cbb\u759717p\u67d3\u8272\u4f53\u7f3a\u5931\u6216TP53\u57fa\u56e0\u7a81\u53d8\u60a3\u8005\uff09\u7684\u521d\u6b65\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e \u4e2d\u56fd\u5317\u4eac\u548c\u7f8e\u56fd\u9ebb\u7701\u5251\u68652021\u5e7412\u670814\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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