{"id":56183,"date":"2021-12-13T07:00:00","date_gmt":"2021-12-13T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021121307000056183"},"modified":"2021-12-13T17:55:08","modified_gmt":"2021-12-13T09:55:08","slug":"%e9%a9%af%e9%b9%bf%e5%8c%bb%e7%96%97%e4%b8%8e%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%90%88%e4%bd%9c%e5%bc%80%e5%8f%91%e7%9a%84bcma-car-t%e6%9c%80%e6%96%b0%e4%b8%b4%e5%ba%8a%e6%95%b0%e6%8d%ae%e4%bb%a5","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021121307000056183","title":{"rendered":"\u9a6f\u9e7f\u533b\u7597\u4e0e\u4fe1\u8fbe\u751f\u7269\u5408\u4f5c\u5f00\u53d1\u7684BCMA CAR-T\u6700\u65b0\u4e34\u5e8a\u6570\u636e\u4ee5\u53e3\u5934\u62a5\u544a\u4eae\u76f8ASH\u5e74\u4f1a"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5357\u4eac\u3001\u4e0a\u6d77\u548c\u7f8e\u56fd\u65e7\u91d1\u5c712021\u5e7412\u670813\u65e5 \/\u7f8e\u901a\u793e\/ — \u9a6f\u9e7f\u533b\u7597\uff0c\u4e00\u5bb6\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u3001\u81f4\u529b\u4e8e\u7ec6\u80de\u6cbb\u7597\u548c\u6297\u4f53\u836f\u7269\u5f00\u53d1\u548c\u4ea7\u4e1a\u5316\u7684\u521b\u65b0\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u4e0e\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u201c\u4fe1\u8fbe\u751f\u7269\u201d\uff09\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5171\u540c\u5ba3\u5e03\u57282021\u5e74\u7b2c63\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u4e0a\u4ee5\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u5c55\u793a\u4e86\u5171\u540c\u5f00\u53d1\u7684\u5168\u4eba\u6e90\u81ea\u4f53B\u7ec6\u80de\u6210\u719f\u6297\u539f\uff08BMCA\uff09\u5d4c\u5408\u6297\u539f\u53d7\u4f53\u81ea\u4f53T\u7ec6\u80de\uff08CAR-T\uff09\u7597\u6cd5\u7684\u6700\u65b01\/2\u671f\u6ce8\u518c\u6027\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\uff08\u9a6f\u9e7f\u533b\u7597\u7814\u53d1\u4ee3\u53f7\uff1aCT103A\uff0c\u4fe1\u8fbe\u751f\u7269\u7814\u53d1\u4ee3\u53f7\uff1aIBI326\uff09\u3002\u53e3\u5934\u62a5\u544a\u6807\u9898\u4e3a\uff1a\u5168\u4eba\u6e90B\u7ec6\u80de\u6210\u719f\u6297\u539f\u7279\u5f02\u6027CAR-T\u7ec6\u80de\uff08CT103A\uff09\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08RRMM\uff09\u60a3\u8005\u76841\/2\u671f\u4e34\u5e8a\u7814\u7a76\uff08\u6458\u8981\u7f16\u53f7\uff1a547\uff09\uff0c\u62a5\u544a\u4eba\u4e3a\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u540c\u6d4e\u533b\u9662\u674e\u6625\u854a\u6559\u6388\u3002<\/p>\n

\n<\/p><\/div>\n

\u672c\u6b21\u4eae\u76f8ASH\u53e3\u5934\u62a5\u544a\u7684\u7814\u7a76\u662f\u4e00\u9879\u6b63\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u5355\u81c2\u3001\u5f00\u653e\u6027\u3001\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\u3002\u7814\u7a76\u4e3b\u8981\u5165\u7ec4\u4e86\u65e2\u5f80\u63a5\u53d7 \u2265 3\u7ebf\u6cbb\u7597\u3001\u6d46\u7ec6\u80de\u819c\u8868\u8fbeBCMA\u9633\u6027\u3001ECOG\u8bc4\u52060-1\u5206\u7684RRMM\u60a3\u8005\uff0c\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a\u603b\u4f53\u7f13\u89e3\u7387\uff08ORR\uff09\uff0c\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\u5305\u62ec\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DOR\uff09\u3001\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u603b\u751f\u5b58\u671f\uff08OS\uff09\uff0c\u4ee5\u53ca\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u836f\u6548\u52a8\u529b\u5b66\u7279\u5f81\u3002\u672c\u6b21\u4f1a\u8bae\u62a5\u544a\u7684\u4e34\u5e8a\u6570\u636e\u622a\u6b62\u65e5\u4e3a2021\u5e7410\u670812\u65e5\uff0c\u7eb3\u5165\u5171\u8ba179\u4f8b\u63a5\u53d7II\u671f\u63a8\u8350\u5242\u91cf\uff08RP2D\uff091.0×106<\/sup> CAR-T\/Kg\u7684\u53d7\u8bd5\u8005\uff08\u5305\u62ec9\u4f8b\u53c2\u4e0e\u7814\u7a76\u8005\u53d1\u8d77\u7684\u65e9\u671f\u63a2\u7d22\u6027\u7814\u7a76 [IIT] \u7684\u53d7\u8bd5\u8005\u4e0e70\u4f8b\u53c2\u4e0e\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76 [NCT05066646] \u7684\u53d7\u8bd5\u8005\uff09\u3002<\/p>\n

\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c<\/b>CT103A<\/b>\u5728\u4eba\u4f53\u5185\u5177\u6709\u4f18\u5f02\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u5e76\u62e5\u6709\u957f\u6548\u6301\u4e45\u7684\u4f53\u5185\u5b58\u7eed\u65f6\u95f4<\/b>\uff0c\u6709\u671b\u6210\u4e3a\u590d\u53d1\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u7684\u7a81\u7834\u6027\u6cbb\u7597\u624b\u6bb5\u3002<\/b><\/p>\n

CT103A<\/b>\u62e5\u6709\u4f18\u5f02\u4e14\u53ef\u63a7\u7684\u5b89\u5168\u6027<\/b>\uff1a79\u4f8b\u53d7\u8bd5\u8005\u4e2d\uff0c75\u4f8b\uff0894.9%\uff09\u53d7\u8bd5\u8005\u53d1\u751f\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\uff0c\u5927\u90e8\u5206\u4e3a1~2\u7ea7CRS\uff0c\u4ec52\u4f8b\u53d7\u8bd5\u8005\u4e3a3\u7ea7CRS\uff08\u5747\u53d1\u751f\u5728IIT\u7814\u7a76\u9636\u6bb5\uff0c\u6ce8\u518c\u4e34\u5e8a\u9636\u6bb570\u4f8b\u53d7\u8bd5\u8005\u672a\u53d1\u751f3\u7ea7\u53ca\u4ee5\u4e0a\u7684CRS\uff09\u3002CRS\u53d1\u751f\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a\u56de\u8f93\u540e\u7b2c6.0\u5929\uff0cCRS\u7684\u4e2d\u4f4d\u6301\u7eed\u65f6\u95f4\u4e3a5.0\u5929\u3002\u4ec51\u4f8b\u53d7\u8bd5\u8005\u51fa\u73b02\u7ea7\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u76f8\u5173\u795e\u7ecf\u7cfb\u7edf\u7efc\u5408\u5f81\uff08ICANS\uff09\uff0c\u8868\u73b0\u4e3a\u4e00\u8fc7\u6027\u610f\u8bc6\u6c34\u5e73\u964d\u4f4e\u6027\uff0c\u81ea\u884c\u7f13\u89e3\u3002\u6240\u6709\u53d7\u8bd5\u8005\u7684CRS\u548cICANS\u5747\u5f97\u5230\u7f13\u89e3\uff0c\u5176\u4e2d20%\u53d7\u8bd5\u8005\u4f7f\u7528\u4e86\u6258\u73e0\u5355\u6297\u6cbb\u7597\uff0c34.7%\u53d7\u8bd5\u8005\u4f7f\u7528\u4e86\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u3002<\/p>\n

CT103A<\/b>\u62e5\u6709\u5353\u8d8a\u4e14\u6301\u4e45\u7684\u6709\u6548\u6027<\/b>\uff1a79\u4f8b\u53d7\u8bd5\u8005\u4e2d\uff0cORR\u4e3a 94.9%\uff0c\u5b8c\u5168\u7f13\u89e3\/\u4e25\u683c\u610f\u4e49\u7684\u5b8c\u5168\u7f13\u89e3\uff08CR\/sCR\uff09\u4e3a58.2%\uff0c\u4e14\u968f\u7740\u968f\u8bbf\u65f6\u95f4\u7684\u5ef6\u957f\uff0c\u53cd\u5e94\u6709\u52a0\u6df1\u7684\u8d8b\u52bf\u3002\u56de\u8f93\u540e6\u4e2a\u6708\u30019\u4e2a\u6708\u548c12\u4e2a\u6708\u7684PFS\u5206\u522b\u4e3a78.0%\u300176.0%\u548c71.0%\u3002CT103A\u5bf9\u5408\u5e76\u9ad3\u5916\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u53d7\u8bd5\u8005\u4ea6\u5c55\u73b0\u4e86\u826f\u597d\u7684\u7597\u6548\uff0c11\u4f8b\u5408\u5e76\u9ad3\u5916\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u53d7\u8bd5\u8005\u7684ORR\u4e3a100%\uff0cCR\/sCR\u4e3a72.7%\u3002\u572879\u4f8b\u53d7\u8bd5\u8005\u4e2d\uff0c93.7%\u53d7\u8bd5\u8005\u5728\u56de\u8f93\u540e\u81f3\u5c11\u8fbe\u5230\u4e00\u6b21\u7075\u654f\u5ea6\u4e3a10-5<\/sup>\u7684\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u9634\u6027\u3002<\/p>\n

CT103A<\/b>\u5bf9\u4e8e\u65e2\u5f80\u63a5\u53d7<\/b>CAR-T<\/b>\u6cbb\u7597\u540e\u590d\u53d1\u7684\u53d7\u8bd5\u8005\u4ecd\u7136\u6709\u826f\u597d\u7684\u7597\u6548\uff1a<\/b>13\u4f8b\u65e2\u5f80\u63a5\u53d7CAR-T\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u7684ORR\u4e3a76.9%\uff0c61.5%\u8fbe\u5230\u975e\u5e38\u597d\u7684\u90e8\u5206\u7f13\u89e3\uff08VGPR\uff09\u53ca\u4ee5\u4e0a\uff0cCR\/sCR\u4e3a46.2%\u3002<\/p>\n

CT103A<\/b>\u5728\u4f53\u5185\u826f\u597d\u6269\u589e\u4e14\u6301\u4e45\u5b58\u7eed\u3002<\/b>\u5916\u5468\u8840CT103A \u7684CAR\u62f7\u8d1d\u6570\u4e2d\u4f4d\u8fbe\u5cf0\u65f6\u95f4\u4e3a12\u5929\uff0c\u4e2d\u4f4d\u5cf0\u503c\u4e3a92,000\u62f7\u8d1d\/ug DNA\u3002\u56de\u8f93\u540e\u968f\u8bbf12\u4e2a\u6708\u768418\u4f8b\u53d7\u8bd5\u8005\u4e2d\uff0c10\u4f8b\uff0855.6%\uff09\u4ecd\u80fd\u68c0\u6d4b\u5230CT103A\u3002\u9996\u4f8b\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u5728\u56de\u8f93\u540e34\u4e2a\u6708\uff081,013\u5929\uff09\u5916\u5468\u8840\u4ecd\u53ef\u68c0\u6d4b\u5230CT103A\u5b58\u7eed\uff084,040 \u62f7\u8d1d\/ug DNA\uff09\uff0c\u8be5\u53d7\u8bd5\u8005\u540c\u65f6\u7ef4\u6301sCR\u72b6\u6001\u3002CT103A\u56de\u8f93\u540e\u5916\u5468\u8840\u6e38\u79bbBCMA\u8fc5\u901f\u4e0b\u964d\u5e76\u957f\u671f\u7ef4\u6301\u4f4e\u4e8e\u68c0\u6d4b\u4e0b\u9650\u3002<\/p>\n

CT103A<\/b>\u5177\u6709\u8f83\u4f4e\u7684\u514d\u75ab\u539f\u6027<\/b>\uff1aCT103A\u56de\u8f93\u540e3\u4e2a\u6708\u5185\u4ec51.3%\uff081\/79\uff09\u53d7\u8bd5\u8005\u51fa\u73b0ADA\u9633\u6027\u3002\u4e2d\u4f4d\u968f\u8bbf7\u4e2a\u6708\uff0c\u4ec512.7%\uff0810\/79\uff09\u51fa\u73b0ADA\u9633\u6027\u3002<\/p>\n

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\u201c\u5c3d\u7ba1\u65e2\u5f80\u9776\u5411BCMA CAR-T \u5728RRMM\u4e2d\u53d6\u5f97\u4e86\u826f\u597d\u7684\u6548\u679c\uff0c\u7136\u800c\u9ad8\u590d\u53d1\u7387\u4f9d\u7136\u662f\u4e00\u4e2a\u9700\u8981\u514b\u670d\u7684\u96be\u9898\u3002CT103A\u662f\u4e00\u79cd\u5168\u4eba\u6e90\u3001\u9776\u5411BCMA\u7684CAR-T \u4ea7\u54c1\uff0c\u53ef\u964d\u4f4e\u5bbf\u4e3b\u6f5c\u5728\u7684\u6297CAR\u514d\u75ab\u539f\u6027\uff0c\u51cf\u5c11\u590d\u53d1\u3002\u8be5\u9879\u7814\u7a76\u663e\u793a\u4e86CT103A\u826f\u597d\u7684\u7597\u6548\u4e0e\u4f18\u5f02\u7684\u5b89\u5168\u6027\uff0c\u540c\u65f6\u5177\u6709\u826f\u597d\u7684\u52a8\u529b\u5b66\u53ca\u8f83\u4f4e\u7684\u514d\u75ab\u539f\u6027\uff0c\u8fd9\u5bf9\u4e8eRRMM\u6cbb\u7597\u5177\u6709\u975e\u5e38\u91cd\u8981\u7684\u4ef7\u503c\uff0c\u662f\u672a\u6765\u7814\u7a76\u7684\u7a81\u7834\u65b9\u5411\u3002\u201d<\/p>\n

\u9a6f\u9e7f\u533b\u7597\u9996\u5e2d\u6267\u884c\u5b98\u517c\u9996\u5e2d\u533b\u5b66\u5b98\u6c6a\u6587\u535a\u58eb\u8868\u793a\uff1a<\/b><\/p>\n

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