{"id":56167,"date":"2021-12-13T07:30:00","date_gmt":"2021-12-13T00:30:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021121307300056167"},"modified":"2021-12-13T17:53:34","modified_gmt":"2021-12-13T09:53:34","slug":"%e7%a7%91%e6%b5%8e%e8%8d%af%e4%b8%9act053-bcma-car-t%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%e5%9c%a82021-ash%e5%b9%b4%e4%bc%9a%e6%9c%80%e6%96%b0%e6%8a%ab%e9%9c%b2","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021121307300056167","title":{"rendered":"\u79d1\u6d4e\u836f\u4e1aCT053 BCMA CAR-T\u7814\u7a76\u6210\u679c\u57282021 ASH\u5e74\u4f1a\u6700\u65b0\u62ab\u9732"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e0a\u6d772021\u5e7412\u670813\u65e5 \/\u7f8e\u901a\u793e\/ — \u79d1\u6d4e\u836f\u4e1a\uff08\u80a1\u7968\u4ee3\u7801\uff1a2171.HK\uff09\uff0c\u4e00\u5bb6\u4e3b\u8981\u4e13\u6ce8\u4e8e\u6cbb\u7597\u8840\u6db2\u6076\u6027\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u7684\u521b\u65b0CAR-T\u7ec6\u80de\u7597\u6cd5\u516c\u53f8\uff0c\u4eca\u65e5\u516c\u544a\uff0c\u57282021\u5e74\u7b2c63\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u4e0a\uff0c \u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684CT053\uff08\u4e00\u79cd\u9776\u5411BCMA\u7684\u81ea\u4f53CAR-T\u7ec6\u80de\u6cbb\u7597\u5019\u9009\u4ea7\u54c1\uff09\u7684\u7814\u7a76\u6210\u679c\u4ee5\u4e24\u7bc7\u6d77\u62a5\u5f62\u5f0f\u8fdb\u884c\u4e86\u5c55\u793a\uff0c\u5176\u5305\u542b\u4e86\uff1a\uff081\uff09\u4e00\u9879\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u2160\/\u2161\u671f\u7814\u7a76\uff08LUMMICAR-1\uff09\u7684\u6301\u7eed\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7ed3\u679c\uff0c\u548c\uff082\uff09\u5728\u590d\u53d1\/\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08R\/R MM\uff09\u53d7\u8bd5\u8005\u4e2d\u7684\u9ad8\u5371\u56e0\u7d20\u6c47\u603b\u5206\u6790\u3002<\/p>\n

\n<\/p><\/div>\n

\u6d77\u62a5<\/b> #2821<\/b>\uff1a<\/b>LUMMICAR-1<\/b>\u7814\u7a76\u7684\u6301\u7eed\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7ed3\u679c\uff1a\u4e00\u9879\u5728\u590d\u53d1<\/b>\/<\/b>\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u4e2d\u56fd\u60a3\u8005\u4e2d\u5f00\u5c55\u7684\u5168\u4eba\u6e90\u9776\u5411<\/b>BCMA CAR-T<\/b>\u7ec6\u80de\uff08<\/b>CT053<\/b>\uff09\u7684\u2160<\/b>\/<\/b>\u2161\u671f\u7814\u7a76<\/b><\/p>\n

\u6c47\u62a5\u4eba\uff1a\u5317\u4eac\u671d\u9633\u533b\u9662 \u9648\u6587\u660e\u6559\u6388<\/p>\n

BCMA\u662f\u9776\u5411\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u7684\u4e00\u79cd\u524d\u666f\u5149\u660e\u7684\u6cbb\u7597\u65b9\u6cd5\u3002CT053\u662f\u4e00\u4e2a\u81ea\u4f53\u7684CAR-T\u7ec6\u80de\u5019\u9009\u4ea7\u54c1\uff0c\u5305\u542b\u4e86\u5168\u4eba\u6e90BCMA\u7279\u5f02\u6027\u5355\u94fe\u53ef\u53d8\u7247\u6bb5\uff0c\u5177\u6709\u9ad8\u7ed3\u5408\u4eb2\u548c\u529b\u548c\u9ad8\u5355\u4f53\u6bd4\u4f8b\u3002<\/p>\n

LUMMICAR-1\u7814\u7a76\u662f\u4e00\u9879\u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u591a\u4e2d\u5fc3\u7684\u3001\u5f00\u653e\u6807\u7b7e\u7684\u2160\/\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8fd9\u4e2a\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u662f\u8bc4\u4f30CT053\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u5e76\u786e\u5b9a\u2161\u671f\u63a8\u8350\u5242\u91cf\u3002\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\u662f\u8fdb\u4e00\u6b65\u8bc4\u4f30\u6709\u6548\u6027\u3001\u5b89\u5168\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u3002\u6709\u6548\u6027\u8bc4\u4f30\u53c2\u7167\u56fd\u9645\u9aa8\u9ad3\u7624\u5de5\u4f5c\u7ec4\uff08IMWG\uff092016\u6807\u51c6\u3002<\/p>\n

\u622a\u81f32021\u5e747\u67088\u65e5\uff0c14\u4f4d\u65e2\u5f80\u7ecf\u591a\u79cd\u6cbb\u7597\u7684R\/R MM\u60a3\u8005\u63a5\u53d7\u4e86CT053\u8f93\u6ce8\u30023\u540d\u60a3\u8005\u63a5\u53d7\u4e861.0×108<\/sup> CAR-T\u7ec6\u80de\uff1b11\u540d\u60a3\u8005\u63a5\u53d7\u4e861.5×108<\/sup> CAR-T\u7ec6\u80de\u3002\u6240\u6709\u7684\u60a3\u8005\u90fd\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e09\u79cd\u524d\u7ebf\u6cbb\u7597\u65b9\u6848\uff0c\u524d\u7ebf\u6cbb\u7597\u65b9\u6848\u7684\u4e2d\u4f4d\u6570\u4e3a6\u3002\u5176\u4e2d\uff0c50%\uff087\/14\uff09\u7684\u60a3\u8005\u5177\u6709\u9ad8\u5371\u7ec6\u80de\u9057\u4f20\u5b66\u5f02\u5e38\uff0c14.3%\uff082\/14\uff09\u7684\u60a3\u8005\u4f34\u6709\u9ad3\u5916\u75c5\u53d8\uff08EMD\uff09\uff0c\u4ee5\u53ca14.3%\uff082\/14\uff09\u7684\u60a3\u8005\u4f34\u6709\u56fd\u9645\u5206\u671f\u7cfb\u7edf\uff08ISS\uff09III\u671f\u3002<\/p>\n

\u5b89\u5168\u6027\uff1a<\/b><\/p>\n

CT053\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u65e0\u22653\u7ea7\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u548c\u795e\u7ecf\u6bd2\u6027\u53d1\u751f\uff0c\u65e0\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\u548c\u6cbb\u7597\u76f8\u5173\u6b7b\u4ea1\u4e8b\u4ef6\u53d1\u751f\u3002\u672a\u68c0\u6d4b\u5230\u836f\u7269\u514d\u75ab\u539f\u6027\u3002<\/p>\n

\u6709\u6548\u6027\uff1a<\/b><\/p>\n

\u622a\u81f32021\u5e747\u67088\u65e5\uff0c\u4e2d\u4f4d\u968f\u8bbf\u671f\u4e3a13.6\u4e2a\u6708\uff08\u8303\u56f44.2-22.4\u4e2a\u6708\uff09\u3002\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a100%\uff0814\/14\uff09\u3002\u5176\u4e2d78.6%\uff0811\/14\uff09\u7684\u60a3\u8005\u8fbe\u5230\u4e25\u683c\u610f\u4e49\u7684\u5b8c\u5168\u7f13\u89e3\uff08sCR\uff09\u4e14\u5168\u90e8\u4e3a\u5fae\u5c0f\u6b8b\u7559\u75c5\u53d8\uff08MRD\uff0910-5<\/sup>\u9634\u6027\uff0c\u5e76\u4e14\u67099\u4f8b\u60a3\u8005\u6301\u7eed\u5b8c\u5168\u7f13\u89e3\u53ca\u4ee5\u4e0a\uff08CR\/sCR\uff09\u8d85\u8fc712\u4e2a\u6708\uff0c92.9%\uff0813\/14\uff09\u7684\u60a3\u8005\u8fbe\u5230\u975e\u5e38\u597d\u7684\u90e8\u5206\u7f13\u89e3\uff08VGPR\uff09\u53ca\u4ee5\u4e0a\u300212\u4e2a\u6708\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u4e3a85.7%\uff0812\/14\uff09\u3002\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08mDOR\uff09\u548c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u8fd8\u6ca1\u6709\u8fbe\u5230\u3002\u5728\u4e0d\u4f34\u6709EMD\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u4e86\u66f4\u4f73\u7684\u6cbb\u7597\u8d8b\u52bf\uff0cCR\/sCR\u7387\u4e3a91.7%\uff0811\/12\uff09\uff0c12\u4e2a\u6708PFS\u7387\u8fbe\u5230100%\u3002<\/p>\n

\u7ed3\u8bba\uff1a<\/b><\/p>\n

\u7ed3\u679c\u8868\u660e\uff0cCT053\u5728R\/R MM\u60a3\u8005\uff0850%\u7684\u60a3\u8005\u5177\u6709\u9ad8\u5371\u7ec6\u80de\u9057\u4f20\u5b66\u5f02\u5e38\uff09\u4e2d\u63d0\u4f9b\u4e86\u6df1\u5ea6\u4e14\u6301\u4e45\u7684\u7597\u6548\u53cd\u5e94\uff0c\u4e14\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\u3002<\/p>\n

 <\/p>\n

\u6d77\u62a5<\/b> #1751<\/b>\uff1a\u9776\u5411<\/b>BCMA CAR-T<\/b>\u7ec6\u80de\uff08<\/b>CT053<\/b>\uff09\u5728\u590d\u53d1<\/b>\/<\/b>\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u53d7\u8bd5\u8005\u4e2d\u7684\u9ad8\u5371\u56e0\u7d20\u6c47\u603b\u5206\u6790<\/b><\/p>\n

\u6c47\u62a5\u4eba\uff1a\u82cf\u5dde\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662 \u5085\u7424\u7424\u6559\u6388<\/p>\n

\u524d\u671f\u5173\u4e8eCT053\u7684\u591a\u9879\u7814\u7a76\uff0c\u5305\u62ec3\u4e2a\u7814\u7a76\u8005\u53d1\u8d77\u8bd5\u9a8c\uff08IIT\uff09\u548cLUMMICAR-1\u7814\u7a76\uff0c\u663e\u793a\u5728\u65e2\u5f80\u7ecf\u8fc7\u591a\u79cd\u6cbb\u7597\u7684R\/R MM\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u6df1\u5ea6\u4e14\u6301\u4e45\u7684\u53cd\u5e94\uff08\u57282020\u5e74\u7684ASH\u5e74\u4f1a\u4e2d\u6c47\u62a5\uff09\u3002\u6211\u4eec\u6c47\u603b\u5206\u6790\u4e86\u8fd9\u51e0\u9879\u7814\u7a76\u57fa\u4e8e\u9ad8\u5371\u56e0\u7d20\uff08\u5305\u62ec\u9ad3\u5916\u75c5\u53d8[EMD]\u3001\u9ad8\u5371\u7ec6\u80de\u9057\u4f20\u5b66\u5f02\u5e38\u548cISS III\u671f\uff09\u5206\u5c42\u7684\u7efc\u5408\u7597\u6548\u548c\u5b89\u5168\u6027\u6570\u636e\u3002<\/p>\n

IIT\u7814\u7a76\u548cLUMMICAR-1\u7814\u7a76\u7684\u6570\u636e\u622a\u6b62\u5206\u522b\u4e3a2021\u5e746\u670830\u65e5\u548c2021\u5e747\u67088\u65e5\uff0c\u5171\u670938\u4f8b\u60a3\u8005\u63a5\u53d7CT053\u7684\u8f93\u6ce8\uff0c\u5176\u4e2d\uff0c1\u4f8b\u63a5\u53d70.5×108<\/sup>\uff0c4\u4f8b\u63a5\u53d71.0×108<\/sup>\uff0c32\u4f8b\u63a5\u53d71.5×108<\/sup>\u548c1\u4f8b\u63a5\u53d71.8×108<\/sup> CAR-T\u7ec6\u80de\u3002\u6240\u6709\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c112\u79cd\u6297\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u65e2\u5f80\u4e2d\u4f4d\u503c\u65b9\u6848\u6570\u4e3a6\uff08\u8303\u56f42-12\uff09\u3002\u5176\u4e2d\uff0c\u4f34\u6709EMD\u3001\u9ad8\u5371\u7ec6\u80de\u9057\u4f20\u5b66\u5f02\u5e38\u548cISS III\u671f\u7684\u60a3\u8005\u5206\u522b\u4e3a31.6%\u300150.0%\u548c28.9%\u3002<\/p>\n

\u6709\u6548\u6027\uff1a<\/b><\/p>\n

\u5728\u4e2d\u4f4d\u968f\u8bbf13.9\u4e2a\u6708\u4e2d\uff0cORR\u4e3a92.1%\uff0835\/38\uff09\uff0c\u5176\u4e2d78.9%\uff0830\/38\uff09\u7684\u60a3\u8005\u8fbe\u5230CR\/sCR\uff0c86.8%\uff0833\/38\uff09\u7684\u60a3\u8005\u8fbe\u5230VGPR\u53ca\u4ee5\u4e0a\u3002mPFS\u548cmDOR\u5206\u522b\u4e3a22.7\u4e2a\u6708\u548c24.0\u4e2a\u6708\u3002<\/p>\n

\u9ad8\u5371\u56e0\u7d20\u5206\u5c42\u5206\u6790\u7684\u7ed3\u679c\u770b\uff0c\u4f34\u6709EMD\u7684\u60a3\u8005\u7684CR\/sCR\u7387\u3001mPFS\u548cmDOR\u5206\u522b\u4e3a58.3%\u30019.3\u4e2a\u6708\u548c9.2\u4e2a\u6708\uff0c\u800c\u65e0EMD\u7684\u60a3\u8005\u5206\u522b\u4e3a88.5%\u300125.0\u4e2a\u6708\u548c24.0\u4e2a\u6708\u3002\u5177\u6709\u9ad8\u5371\u7ec6\u80de\u9057\u4f20\u5b66\u5f02\u5e38\u7684\u60a3\u8005\u7684mPFS\u548cmDOR\u5206\u522b\u4e3a15.6\u4e2a\u6708\u548c18.3\u4e2a\u6708\uff0cISS III\u671f\u60a3\u8005\u7684mPFS\u548cmDOR\u5747\u4e3a13.3\u4e2a\u6708\uff0c\u800c\u6ca1\u6709\u9ad8\u5371\u7ec6\u80de\u9057\u4f20\u5b66\u5f02\u5e38\u548c\u975eISS III\u671f\u60a3\u8005\u7684mPFS\u548cmDOR\u5747\u672a\u8fbe\u5230\u3002\u7ed3\u679c\u8868\u660e\u57fa\u7ebf\u65f6\u4f34\u6709EMD\u3001\u9ad8\u5371\u7ec6\u80de\u9057\u4f20\u5b66\u5f02\u5e38\u6216ISS III\u671f\u7684\u60a3\u8005\u53ef\u80fd\u662f\u5f71\u54cd\u4e34\u5e8a\u83b7\u76ca\u7684\u9ad8\u5371\u56e0\u7d20\u3002<\/p>\n

\u8be6\u60c5\u89c1\u4e0b\u8868\uff1a<\/p>\n

\n\n\n\n\n\n\n\n\n\n
<\/td>\n\n

\u9ad3\u5916\u75c5\u53d8\u72b6\u6001<\/b><\/span><\/p>\n<\/td>\n

\n

\u9ad8\u5371\u7ec6\u80de\u9057\u4f20\u5b66\u5f02\u5e38<\/b><\/span><\/p>\n<\/td>\n

\n

ISS <\/b>\u5206\u671f<\/b><\/span><\/p>\n<\/td>\n

\n

\u5408\u8ba1<\/b><\/span><\/p>\n

N=38<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

<\/td>\n\n

EMD<\/b><\/span><\/p>\n

n=12<\/b><\/span><\/p>\n<\/td>\n

\n

Non-EMD<\/b><\/span><\/p>\n

n=26<\/b><\/span><\/p>\n<\/td>\n

\n

HR-cyto<\/b><\/span><\/p>\n

n=19<\/b><\/span><\/p>\n<\/td>\n

\n

Non-HR-cyto<\/b><\/span><\/p>\n

n=19<\/b><\/span><\/p>\n<\/td>\n

\n

ISS III<\/b><\/span><\/p>\n

n=11<\/b><\/span><\/p>\n<\/td>\n

\n

Non-ISS III<\/b><\/span><\/p>\n

n=27<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\uff0c\u6708<\/b><\/span><\/p>\n<\/td>\n

\n

9.3<\/span><\/p>\n<\/td>\n

\n

14.9<\/span><\/p>\n<\/td>\n

\n

12.9<\/span><\/p>\n<\/td>\n

\n

15.4<\/span><\/p>\n<\/td>\n

\n

12.2<\/span><\/p>\n<\/td>\n

\n

15.4<\/span><\/p>\n<\/td>\n

\n

13.9<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

ORR, n(%)<\/b><\/span><\/p>\n<\/td>\n

\n

11<\/span><\/p>\n

(91.7%)<\/span><\/p>\n<\/td>\n

\n

24<\/span><\/p>\n

(92.3%)<\/span><\/p>\n<\/td>\n

\n

16<\/span><\/p>\n

(84.2%)<\/span><\/p>\n<\/td>\n

\n

19<\/span><\/p>\n

(100%)<\/span><\/p>\n<\/td>\n

\n

9<\/span><\/p>\n

(81.8%)<\/span><\/p>\n<\/td>\n

\n

26<\/span><\/p>\n

(96.3%)<\/span><\/p>\n<\/td>\n

\n

35<\/span><\/p>\n

(92.1%)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

CR\/sCR, n(%)<\/b><\/span><\/p>\n<\/td>\n

\n

7<\/span><\/p>\n

(58.3%)<\/span><\/p>\n<\/td>\n

\n

23<\/span><\/p>\n

(88.5%)<\/span><\/p>\n<\/td>\n

\n

14<\/span><\/p>\n

(73.7%)<\/span><\/p>\n<\/td>\n

\n

16<\/span><\/p>\n

(84.2%)<\/span><\/p>\n<\/td>\n

\n

8<\/span><\/p>\n

(72.7%)<\/span><\/p>\n<\/td>\n

\n

22<\/span><\/p>\n

(81.5%)<\/span><\/p>\n<\/td>\n

\n

30<\/span><\/p>\n

(78.9%)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

mPFS<\/b>\uff0c\u6708<\/b><\/span><\/p>\n

(95%CI)<\/b><\/span><\/p>\n<\/td>\n

\n

9.3<\/span><\/p>\n

(2.8, NR)<\/span><\/p>\n<\/td>\n

\n

25.0<\/span><\/p>\n

(15.6, NR)<\/span><\/p>\n<\/td>\n

\n

15.6<\/span><\/p>\n

(10.1, 25.0)<\/span><\/p>\n<\/td>\n

\n

NR<\/span><\/p>\n

(11.2, NR)<\/span><\/p>\n<\/td>\n

\n

13.3<\/span><\/p>\n

(0.9, NR)<\/span><\/p>\n<\/td>\n

\n

NR<\/span><\/p>\n

(15.6, NR)<\/span><\/p>\n<\/td>\n

\n

22.7<\/span><\/p>\n

(13.3, NR)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

mDOR<\/b>\uff0c\u6708<\/b><\/span><\/p>\n

(95%CI)<\/b><\/span><\/p>\n<\/td>\n

\n

9.2<\/span><\/p>\n

(2.8, NR)<\/span><\/p>\n<\/td>\n

\n

24.0<\/span><\/p>\n

(14.8, NR)<\/span><\/p>\n<\/td>\n

\n

18.3<\/span><\/p>\n

(9.2, NR)<\/span><\/p>\n<\/td>\n

\n

NR<\/span><\/p>\n

(10.3, NR)<\/span><\/p>\n<\/td>\n

\n

13.3<\/span><\/p>\n

(7.6, NR)<\/span><\/p>\n<\/td>\n

\n

NR<\/span><\/p>\n

(14.8, NR)<\/span><\/p>\n<\/td>\n

\n

24.0<\/span><\/p>\n

(13.3, NR)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

\u6ce8\uff1aEMD: <\/b>\u9ad3\u5916\u75c5\u53d8\uff1bHR-cyto: <\/b>\u9ad8\u5371\u7ec6\u80de\u9057\u4f20\u5b66\u5f02\u5e38\uff1bNR: <\/b>\u672a\u8fbe\u5230\uff1bISS: <\/b>\u56fd\u9645\u5206\u671f\u7cfb\u7edf<\/p>\n

\u5b89\u5168\u6027\uff1a<\/b><\/p>\n

\u65e0DLT\u6216\u8005\u6cbb\u7597\u76f8\u5173\u6b7b\u4ea1\u4e8b\u4ef6\u53d1\u751f\u30021\u7ea7\u62162\u7ea7\u7684CRS\u53d1\u751f\u7387\u4e3a73.7%\uff0c\u4e14\u6ca1\u6709\u22653\u7ea7\u7684CRS\u53d1\u751f\u3002\u4ec51\u4f8b\uff082.6%\uff0c 1\/38\uff09\u60a3\u8005\u53d1\u751f3\u7ea7\u795e\u7ecf\u6bd2\u6027\uff08\u766b\u75eb\uff09\uff0c\u4e14\u7ecf\u7532\u6cfc\u5c3c\u9f99\u6cbb\u7597\u540e\u5b8c\u5168\u6062\u590d\uff0c\u8be5\u60a3\u8005ISS III\u671f\uff0c\u5408\u5e76EMD\u3002<\/p>\n

\u7ed3\u8bba\uff1a<\/b><\/p>\n

CT053\u5728R\/R MM\u60a3\u8005\u4e2d\uff08\u5305\u62ec\u9ad8\u5371\u4eba\u7fa4\uff09\u662f\u4e00\u79cd\u5177\u6709\u524d\u666f\u7684\u6cbb\u7597\u624b\u6bb5\uff0c\u4e14\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\u3002<\/p>\n

\u5317\u4eac\u671d\u9633\u533b\u9662\u8840\u6db2\u79d1\u4e3b\u4efb\u533b\u5e08\u9648\u6587\u660e\u6559\u6388\u5728\u62a5\u544a\u4e2d\u8868\u793a\uff1a\u201cLUMMICAR-1\u7814\u7a76\u7ed3\u679c\u8bc1\u5b9e\u5168\u4eba\u6e90\u9776\u5411BCMA CAR-T\u7ec6\u80de\u4ea7\u54c1CT053\u5728\u590d\u53d1\/\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u4e2d\u63d0\u4f9b\u4e86\u6df1\u5ea6\u4e14\u6301\u4e45\u7684\u7597\u6548\u53cd\u5e94\uff0c\u4e14\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\u3002\u201d<\/p>\n

\u82cf\u5dde\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u8840\u6db2\u5185\u79d1\u4e3b\u4efb\u533b\u5e08\u5085\u7424\u7424\u6559\u6388\u5728\u62a5\u544a\u4e2d\u8868\u793a\uff1a\u201c\u57fa\u7ebf\u4f34\u6709EMD\u3001\u9ad8\u5371\u7ec6\u80de\u9057\u4f20\u5b66\u5f02\u5e38\u6216ISS III\u671f\u7b49\u4e3a\u5f71\u54cd\u590d\u53d1\/\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u4e34\u5e8a\u7597\u6548\u7684\u9ad8\u5371\u56e0\u7d20\uff0c\u4f46CT053\u5728\u8fd9\u4e9b\u5408\u5e76\u9ad8\u5371\u56e0\u7d20\u60a3\u8005\u4e2d\u4ecd\u7136\u663e\u793a\u51fa\u5f88\u597d\u7684\u4e34\u5e8a\u83b7\u76ca\u3002\u201d<\/p>\n

\u79d1\u6d4e\u836f\u4e1a\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u4f1a\u4e3b\u5e2d\u3001\u9996\u5e2d\u6267\u884c\u5b98\u3001\u9996\u5e2d\u79d1\u5b66\u5b98\u674e\u5b97\u6d77\u535a\u58eb\u8868\u793a\uff1a\u201c\u611f\u8c22\u9648\u6587\u660e\u6559\u6388\u548c\u5085\u7424\u7424\u6559\u6388\u4ee3\u8868\u7814\u7a76\u8005\u56e2\u961f\u5728ASH\u5e74\u4f1a\u4e0a\u4e0e\u4e1a\u754c\u5206\u4eabCT053\u7684\u7814\u7a76\u6570\u636e\uff0c\u611f\u8c22\u6240\u6709\u7814\u7a76\u8005\u4e3a\u672c\u9879\u76ee\u7684\u503e\u529b\u4ed8\u51fa\u3002\u5e0c\u671bCT053\u80fd\u91cd\u5851\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u5e76\u6210\u4e3a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u7684\u57fa\u7840\u6027\u6cbb\u7597\u65b9\u6cd5\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u201d<\/p>\n

\u5173\u4e8e<\/b>CT053<\/b><\/p>\n

CT053\u662f\u4e00\u79cd\u5347\u7ea7\u7684\u3001\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u5168\u4eba\u6297\u81ea\u4f53BCMA CAR-T\u7ec6\u80de\u5019\u9009\u4ea7\u54c1\u3002\u5176\u878d\u5408\u4e86\u79d1\u6d4e\u836f\u4e1a\u8bbe\u8ba1\u7684\u5347\u7ea7\u7248CAR\u7ed3\u6784\uff0c\u5177\u6709\u8f83\u4f4e\u514d\u75ab\u539f\u6027\u548c\u8f83\u9ad8\u7a33\u5b9a\u6027\u7684\u5168\u4eba\u6297BCMA\u7279\u5f02\u6027\u5355\u94fe\u6297\u4f53\uff0c\u5728\u6ca1\u6709\u80bf\u7624\u76f8\u5173\u9776\u70b9\u7684\u60c5\u51b5\u4e0b\uff0c\u53ef\u964d\u4f4eCAR\u7ec6\u80de\u7684\u81ea\u52a8\u6fc0\u6d3b\u3002<\/p>\n

\u79d1\u6d4e\u836f\u4e1a\u5df2\u5b8c\u6210\u2160\u671f\u8bd5\u9a8c\uff0c\u5e76\u5206\u522b\u5728\u4e2d\u56fd\u5f00\u5c55\u2160\/\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08LUMMICAR STUDY 1\uff09\u548c\u5728\u5317\u7f8e\u5f00\u5c551b\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08LUMMICAR STUDY 2\uff09\u7684\u5173\u952e2\u671f\u8bd5\u9a8c\u90e8\u5206\uff0c\u4ee5\u8bc4\u4f30CT053\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u5b89\u5168\u6027\u53ca\u7597\u6548\u3002\u79d1\u6d4e\u836f\u4e1a\u8ba1\u5212\u4e8e2022\u5e74\u4e0a\u534a\u5e74\u5411\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\u53ca\u4e8e2023\u5e74\u4e0a\u534a\u5e74\u5411\u7f8e\u56fdFDA\u63d0\u4ea4\u4e0a\u5e02\u6279\u51c6\u7684\u76d1\u7ba1\u7533\u8bf7\u3002\u516c\u53f8\u4e5f\u8ba1\u5212\u8fdb\u884c\u5176\u4ed6\u4e34\u5e8a\u8bd5\u9a8c\u4ee5\u5f00\u53d1CT053\u4f5c\u4e3a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u65e9\u7ebf\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n

CT053\u4e8e2019\u5e74\u83b7\u5f97\u7f8e\u56fdFDA\u7684\u201c\u518d\u751f\u533b\u5b66\u5148\u8fdb\u7597\u6cd5\u201d\uff08RMAT\uff09\u53ca\u201c\u5b64\u513f\u836f\u201d\u79f0\u53f7\uff0c\u4ee5\u53ca\u5148\u540e\u4e8e2019\u5e74\u53ca2020\u5e74\u83b7\u5f97\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u7684\u201c\u4f18\u5148\u836f\u7269\u201d\uff08PRIME\uff09\u53ca\u201c\u5b64\u513f\u836f\u4ea7\u54c1\u201d\u79f0\u53f7\u3002CT053\u4e5f\u4e8e2020\u5e74\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\u7684\u201c\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u54c1\u79cd\u201d\u3002<\/p>\n

\u5173\u4e8e\u79d1\u6d4e\u836f\u4e1a<\/b><\/p>\n

\u79d1\u6d4e\u836f\u4e1a\uff08\u80a1\u7968\u4ee3\u7801\uff1a2171.HK\uff09\u662f\u4e00\u5bb6\u5728\u4e2d\u56fd\u53ca\u7f8e\u56fd\u62e5\u6709\u4e1a\u52a1\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e3b\u8981\u4e13\u6ce8\u4e8e\u6cbb\u7597\u8840\u6db2\u6076\u6027\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u7684\u521b\u65b0CAR-T\u7ec6\u80de\u7597\u6cd5\u3002\u6211\u4eec\u5efa\u7acb\u4e86\u4e00\u4e2a\u7efc\u5408\u7ec6\u80de\u6cbb\u7597\u5e73\u53f0\uff0c\u5176\u5185\u90e8\u80fd\u529b\u6db5\u76d6\u4ece\u9776\u70b9\u53d1\u73b0\u3001\u6297\u4f53\u5f00\u53d1\u3001\u4e34\u5e8a\u8bd5\u9a8c\u5230\u5546\u4e1a\u89c4\u6a21\u751f\u4ea7\u3002\u6211\u4eec\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u65b0\u6280\u672f\u4ee5\u53ca\u62e5\u6709\u5168\u7403\u6743\u76ca\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u4ee5\u89e3\u51b3CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u91cd\u5927\u6311\u6218\uff0c\u6bd4\u5982\u63d0\u9ad8\u5b89\u5168\u6027\uff0c\u63d0\u9ad8\u6cbb\u7597\u5b9e\u4f53\u7624\u7684\u7597\u6548\u548c\u964d\u4f4e\u6cbb\u7597\u6210\u672c\u3002\u6211\u4eec\u7684\u4f7f\u547d\u662f\u6210\u4e3a\u80fd\u4e3a\u5168\u7403\u764c\u75c7\u60a3\u8005\u5e26\u6765\u521b\u65b0\u548c\u5dee\u5f02\u5316\u7684\u7ec6\u80de\u7597\u6cd5\uff0c\u5e76\u4f7f\u764c\u75c7\u53ef\u6cbb\u6108\u7684\u5168\u7403\u751f\u7269\u5236\u836f\u9886\u5bfc\u8005\u3002<\/p>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u6d772021\u5e7412\u670813\u65e5 \/\u7f8e\u901a\u793e\/ — 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