{"id":56164,"date":"2021-12-12T08:01:00","date_gmt":"2021-12-12T01:01:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021121208010056164"},"modified":"2021-12-13T17:53:22","modified_gmt":"2021-12-13T09:53:22","slug":"%e8%89%be%e4%bc%8f%e5%b0%bc%e5%b8%83%e8%81%94%e5%90%88%e9%98%bf%e6%89%8e%e8%83%9e%e8%8b%b7%e7%9a%84iii%e6%9c%9f%e7%a0%94%e7%a9%b6%e7%bb%93%e6%9e%9c%e6%98%be%e7%a4%ba%e5%8f%af%e6%98%be%e8%91%97","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021121208010056164","title":{"rendered":"\u827e\u4f0f\u5c3c\u5e03\u8054\u5408\u963f\u624e\u80de\u82f7\u7684III\u671f\u7814\u7a76\u7ed3\u679c\u663e\u793a\u53ef\u663e\u8457\u6539\u5584\u521d\u6cbbIDH1\u7a81\u53d8\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u7684\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\u548c\u603b\u751f\u5b58\u671f"},"content":{"rendered":"<ul type=\"disc\">\n<li><i>\u4e0e\u5b89\u6170\u5242\u8054\u5408\u963f\u624e\u80de\u82f7\u76f8\u6bd4\uff0c\u827e\u4f0f\u5c3c\u5e03\u8054\u5408\u963f\u624e\u80de\u82f7\u5728\u5b8c\u5168\u7f13\u89e3\u7387\u3001\u5b8c\u5168\u7f13\u89e3\u548c\u5b8c\u5168\u7f13\u89e3\u4f34\u90e8\u5206\u8840\u6db2\u5b66\u6062\u590d\u7684\u7f13\u89e3\u7387\u3001\u4ee5\u53ca\u5ba2\u89c2\u7f13\u89e3\u7387\u65b9\u9762\u5b9e\u73b0\u663e\u8457\u6539\u5584<\/i> <\/li>\n<li><i>\u827e\u4f0f\u5c3c\u5e03\u8054\u5408\u963f\u624e\u80de\u82f7\u7684\u5b89\u5168\u6027\u7279\u5f81\u826f\u597d\uff0c\u4e0e\u6b64\u524d\u516c\u5e03\u6570\u636e\u4fdd\u6301\u4e00\u81f4<\/i> <\/li>\n<li><i>AGILE<\/i><i>\u7814\u7a76<\/i><i>III<\/i><i>\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6cbb\u7597\u521d\u6cbb<\/i><i>IDH1<\/i><i>\u7a81\u53d8\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u7684\u6570\u636e\u5c06\u4e8e<span id=\"spanHghltecdf\">\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f4<\/span><\/i><i>2021<\/i><i>\u5e74<\/i><i>12<\/i><i>\u6708<\/i><i>13<\/i><i>\u65e5\uff08\u5468\u4e00\uff09\u5728\u7b2c<\/i><i>63<\/i><i>\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\u5e74\u4f1a\u4ee5\u53e3\u5934\u62a5\u544a\u5bf9\u5916\u53d1\u5e03\uff0c\u5e76\u88ab\u7eb3\u5165\u5927\u4f1a\u7684\u5b98\u65b9\u65b0\u95fb\u53d1\u5e03\u4e2d<\/i><\/li>\n<\/ul>\n<p><p>\u4e2d\u56fd\u82cf\u5dde2021\u5e7412\u670812\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u57fa\u77f3\u836f\u4e1a\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a2616\uff09\u5408\u4f5c\u4f19\u4f34\u65bd\u7ef4\u96c5\u4eca\u65e5\u516c\u5e03\u4e86\u5168\u7403AGILE\u7814\u7a76\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u836f\u7269\u963f\u624e\u80de\u82f7\u76f8\u6bd4\uff0c\u827e\u4f0f\u5c3c\u5e03\uff08ivosidenib\uff09\u8054\u5408\u963f\u624e\u80de\u82f7\u663e\u8457\u63d0\u9ad8\u4e86\u521d\u6cbbIDH1\u7a81\u53d8\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u60a3\u8005\u7684\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\u548c\u603b\u751f\u5b58\u671f\u3002\u8fd9\u4e9b\u6570\u636e\u5c06\u4e8e\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f42021\u5e7412\u670813\u65e5\uff08\u5468\u4e00\uff09\u4e0b\u53482:45-4:15\u5728\u7b2c63\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\u5e74\u4f1a\u66a8\u535a\u89c8<span id=\"spanHghltb34b\">\u4f1a\u4ee5<\/span>\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u516c\u5e03\uff08\u6458\u8981\u7f16\u53f7\uff1a697\uff09\uff0c\u5e76\u88ab\u7eb3\u5165\u5927\u4f1a\u7684\u5b98\u65b9\u65b0\u95fb\u53d1\u5e03\u4e2d\u3002<\/p>\n<p>\u827e\u4f0f\u5c3c\u5e03\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u7ec4\u60a3\u8005\u7684\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u83b7\u5f97\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u663e\u8457\u6539\u5584\uff08\u98ce\u9669\u6bd4[HR]=0.33[95% CI 0.16,0.69]\uff0c\u5355\u4fa7P\u503c=0.0<span id=\"spanHghltbf6a\">011<\/span>\uff09<sup>[1],[<\/sup><sup>2]<\/sup>\u3002\u6b64\u5916\uff0c\u827e\u4f0f\u5c3c\u5e03\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u7ec4\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u540c\u6837\u83b7\u5f97\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u663e\u8457\u6539\u5584\uff08HR=0.44 [95%CI 0.27,0.73]\uff1b\u5355\u4fa7P\u503c=0.0005\uff09\uff0c\u827e\u4f0f\u5c3c\u5e03\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u7ec4\u60a3\u8005\u7684\u4e2d\u4f4dOS\u4e3a24.0\u4e2a\u6708\uff0c\u800c\u5b89\u6170\u5242\u8054\u5408\u963f\u624e\u80de\u82f7\u7ec4\u60a3\u8005\u7684\u4e2d\u4f4dOS\u4e3a7.9\u4e2a\u6708\u3002<\/p>\n<p>\u6839\u636e\u548c\u65bd\u7ef4\u96c5\u8fbe\u6210\u7684\u72ec\u5bb6\u5408\u4f5c\u6388\u6743\u8bb8\u53ef\u534f\u8bae\uff0c\u57fa\u77f3\u836f\u4e1a\u5c31\u827e\u4f0f\u5c3c\u5e03\u5728\u5305\u62ec\u4e2d\u56fd\u5927\u9646\u3001\u9999\u6e2f\u3001\u53f0\u6e7e\u53ca\u6fb3\u95e8\u5730\u533a\u5728\u5185\u7684\u5927\u4e2d\u534e\u5730\u533a\u4ee5\u53ca\u65b0\u52a0\u5761\u5730\u533a\u8fdb\u884c\u4e34\u5e8a\u5f00\u53d1\u4e0e\u5546\u4e1a\u5316\u30022019\u5e747\u670819\u65e5\uff0c\u57fa\u77f3\u836f\u4e1a\u5ba3\u5e03\u5168\u7403III\u671f\u6ce8\u518c\u8bd5\u9a8cAGILE\u5728\u4e2d\u56fd\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002\u4e2d\u56fd\u5171\u670916\u5bb6\u7814\u7a76\u4e2d\u5fc3\u53c2\u4e0e\u4e86AGILE\u7814\u7a76\u3002<\/p>\n<p><b>AGILE<\/b><b>\u7814\u7a76\u4e2d\u56fd\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u8840\u6db2\u75c5\u533b\u9662\u738b\u5efa\u7965\u6559\u6388<\/b>\u8868\u793a\uff1a\u201c\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u662f\u4e00\u79cd\u8fdb\u5c55\u8fc5\u901f\u3001\u5371\u53ca\u751f\u547d\u7684\u6076\u6027\u8840\u6db2\u7cfb\u7edf\u75be\u75c5\u3002\u8001\u5e74\u4ee5\u53ca\u4e0d\u9002\u5408\u63a5\u53d7\u5f3a\u70c8\u8bf1\u5bfc\u5316\u7597\u7684\u65b0\u8bca\u65ad\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u9884\u540e\u8f83\u5dee\u3002\u5bf9\u4e8e\u8fd9\u90e8\u5206\u60a3\u8005\u6765\u8bf4\uff0c\u6211\u4eec\u7684\u6cbb\u7597\u76ee\u6807\u662f\u5ef6\u957f\u603b\u751f\u5b58\u671f\u3002\u6b64\u6b21\u516c\u5e03\u7684\u827e\u4f0f\u5c3c\u5e03\u7684\u7814\u7a76\u6570\u636e\u5c55\u793a\u51fa\u4e86\u663e\u8457\u7684\u4e34\u5e8a\u83b7\u76ca\uff0c\u5c06\u4f1a\u4e3a\u5148\u524d\u672a\u7ecf\u6cbb\u7597\u7684IDH1\u7a81\u53d8\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/p>\n<p><b>\u57fa\u77f3\u836f\u4e1a\u9996\u5e2d\u533b\u5b66\u5b98\u6768\u5efa\u65b0\u535a\u58eb<\/b>\u8868\u793a\uff1a\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u591f\u4e3a\u5148\u524d\u672a\u7ecf\u6cbb\u7597\u7684IDH1\u7a81\u53d8AML\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u8be5\u7814\u7a76\u6570\u636e\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u827e\u4f0f\u5c3c\u5e03\u53ef\u4e3aIDH1\u7a81\u53d8\u7684\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u5e26\u6765\u663e\u8457\u4e34\u5e8a\u53d7\u76ca\uff0c\u5b9e\u73b0AML\u7684\u7cbe\u51c6\u6cbb\u7597\uff0c\u5927\u5e45\u5ea6\u63d0\u9ad8\u60a3\u8005\u7684\u751f\u5b58\u7387\u3002\u540c\u65f6\uff0c\u6211\u4eec\u8ba1\u5212\u4e0e\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u5c55\u5f00\u6c9f\u901a\uff0c\u5c3d\u65e9\u5c06\u8fd9\u4e00\u521b\u65b0\u7597\u6cd5\u5e26\u7ed9\u4e2d\u56fd\u60a3\u8005\u3002\u201d<\/p>\n<p><u>\u5176\u4ed6\u7814\u7a76\u7ed3\u679c<\/u><\/p>\n<p>\u7814\u7a76\u4eba\u5458\u62a5\u544a\u4e86AGILE\u7814\u7a76\u7684\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u7ed3\u679c\uff0c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u827e\u4f0f\u5c3c\u5e03\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u7ec4\u60a3\u8005\u7684\u5b8c\u5168\u7f13\u89e3\u7387\uff08CR\uff09\u4e3a47.2%\uff08n=34\/72\uff09\uff0c\u5b89\u6170\u5242\u8054\u5408\u963f\u624e\u80de\u82f7\u7ec4\u60a3\u8005\u7684\u5b8c\u5168\u7f13\u89e3\u7387\u4e3a14.9%\uff08n=11\/74\uff09\uff08p&lt;0.0001\uff09\u3002 <\/li>\n<li>\u827e\u4f0f\u5c3c\u5e03\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u7ec4\u60a3\u8005\u7684CR+\u5b8c\u5168\u7f13\u89e3\u4f34\u90e8\u5206\u8840\u6db2\u5b66\u6062\u590d\u7684\u7f13\u89e3\u7387\uff08CR+CRh\u7387\uff09\u4e3a52.8%\uff08n=38\/72\uff09\uff0c\u800c\u5b89\u6170\u5242\u8054\u5408\u963f\u624e\u80de\u82f7\u7ec4\u4e3a17.6%\uff08n=13\/74\uff09\uff08p&lt;0.0001\uff09\u3002 <\/li>\n<li>\u827e\u4f0f\u5c3c\u5e03\u8054\u5408\u963f\u624e\u80de\u82f7\u6cbb\u7597\u7ec4\u60a3\u8005\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a62.5%\uff08n=45\/72\uff09\uff0c\u800c\u5b89\u6170\u5242\u8054\u5408\u963f\u624e\u80de\u82f7\u7ec4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a18.9%\uff08n=14\/74\uff09\uff08p&lt;0.0001\uff09\u3002<\/li>\n<\/ul>\n<p>\u827e\u4f0f\u5c3c\u5e03\u8054\u5408\u963f\u624e\u80de\u82f7\u7ec4\u4e0e\u5b89\u6170\u5242\u8054\u5408\u963f\u624e\u80de\u82f7\u7ec4\u60a3\u8005\u5e38\u89c1\uff0820%\u4ee5\u4e0a\uff09\u7684\u6240\u6709\u7ea7\u522b\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u5305\u62ec\u6076\u5fc3\uff0842.3% vs 38.4%\uff09\u3001\u5455\u5410\uff0840.8% vs 26.0%\uff09\u3001\u8179\u6cfb\uff0835.2% vs 35.6%\uff09\u3001\u53d1\u70ed\uff0833.8% vs 39.7%\uff09\u3001\u8d2b\u8840\uff0831.0% vs 28.8%\uff09\u3001\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0828.2% vs 34.2%\uff09\uff0c\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff0828.2% vs 20.5%\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0828.2% vs 16.4%\uff09\u3001\u4fbf\u79d8\uff0826.8% vs 52.1%\uff09\u548c\u80ba\u708e\uff0823.9% vs 31.5%\uff09\u3002<\/p>\n<p>\u827e\u4f0f\u5c3c\u5e03\u5df2\u5728\u7f8e\u56fd\u83b7\u6279\uff0c\u7528\u4e8e\u5355\u836f\u6cbb\u7597IDH1\u7a81\u53d8\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027AML\u6210\u4eba\u60a3\u8005\uff0c\u4ee5\u53ca\u65b0\u8bca\u65ad\u7684\u5e74\u9f84\u226575\u5c81\u6216\u56e0\u5408\u5e76\u75c7\u65e0\u6cd5\u4f7f\u7528\u5f3a\u70c8\u8bf1\u5bfc\u5316\u7597\u7684IDH1\u7a81\u53d8AML\u6210\u4eba\u60a3\u8005\u3002\u8fd1\u671f\uff0c\u827e\u4f0f\u5c3c\u5e03\u5df2\u83b7\u6279\u51c6\u4f5c\u4e3a\u9996\u4e2a\u4e14\u552f\u4e00\u7528\u4e8e\u7ecf\u6cbbIDH1\u7a81\u53d8\u80c6\u7ba1\u764c\u60a3\u8005\u7684\u9776\u5411\u836f\u7269\u3002<\/p>\n<p>2020\u5e74\uff0c\u827e\u4f0f\u5c3c\u5e03\u88ab\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u7eb3\u5165\u201c\u4e34\u5e8a\u6025\u9700\u5883\u5916\u65b0\u836f\u540d\u5355\uff08\u7b2c\u4e09\u6279\uff09\u201d\uff0c\u83b7\u5f97\u5feb\u901f\u901a\u9053\u5ba1\u8bc4\u5ba1\u6279\u8d44\u683c\u3002\u540c\u65f6\uff0c\u4f5c\u4e3a\u5168\u7403\u540c\u7c7b\u9996\u521b\u7684\u5f3a\u6548\u3001\u9ad8\u9009\u62e9\u6027\u53e3\u670dIDH1\u6291\u5236\u5242\uff0c\u827e\u4f0f\u5c3c\u5e03\u4ee5\u5176\u660e\u786e\u7684\u4e34\u5e8a\u4f18\u52bf\uff0c\u5165\u9009\u4e862020\u7248\u300aCSCO\u6076\u6027\u8840\u6db2\u75c5\u8bca\u7597\u6307\u5357\u300b\u3002\u76ee\u524d\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5df2\u53d7\u7406\u827e\u4f0f\u5c3c\u5e03\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff0c\u7528\u4e8e\u6cbb\u7597\u643a\u5e26IDH1\u6613\u611f\u7a81\u53d8\u7684\u6210\u4eba\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>AGILE III<\/b><b>\u671f<\/b><b>AML<\/b><b>\u7814\u7a76<\/b><b>&nbsp;<\/b><b>\uff08<\/b><b>NCT03173248<\/b><b>\uff09<\/b><\/p>\n<p>AGILE\u7814\u7a76\u662f\u4e00\u9879\u5168\u7403III\u671f\u3001\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u827e\u4f0f\u5c3c\u5e03\u8054\u5408\u963f\u624e\u80de\u82f7\u4e0e\u5b89\u6170\u5242\u8054\u5408\u963f\u624e\u80de\u82f7\uff0c\u5728\u4e0d\u7b26\u5408\u5f3a\u70c8\u5316\u7597\u6761\u4ef6\u7684\u65b0\u8bca\u65adAML\u60a3\u8005\u4e2d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662fEFS\uff0c\u5b9a\u4e49\u4e3a\u4ece\u968f\u673a\u5230\u6cbb\u7597\u5931\u8d25\u3001\u7f13\u89e3\u540e\u590d\u53d1\u6216\u4efb\u4f55\u539f\u56e0\u5f15\u8d77\u7684\u6b7b\u4ea1(\u4ee5\u5148\u53d1\u751f\u8005\u4e3a\u51c6)\u7684\u65f6\u95f4\u3002\u6cbb\u7597\u5931\u8d25\u7684\u5b9a\u4e49\u4e3a\u76f4\u5230\u7b2c24\u5468\u60a3\u8005\u4ecd\u672a\u80fd\u8fbe\u5230CR\u3002<\/p>\n<p>\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\uff1a&nbsp;CR\u7387\uff0c\u5b9a\u4e49\u4e3a\u8fbe\u5230CR\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\uff1b&nbsp;OS\uff0c\u5b9a\u4e49\u4e3a\u4ece\u968f\u673a\u65e5\u671f\u5230\u4efb\u4f55\u539f\u56e0\u7684\u6b7b\u4ea1\u65e5\u671f\u7684\u65f6\u95f4\uff1bCR\u548c\u4f34\u90e8\u5206\u8840\u6db2\u5b66\u6062\u590d\u7684\u5b8c\u5168\u7f13\u89e3\uff08CRh\uff09\u7387\uff0c\u5b9a\u4e49\u4e3a\u8fbe\u5230CR\u6216CRh\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\uff1bORR\uff0c\u5b9a\u4e49\u4e3a\u8fbe\u5230CR\u3001CR\u4f34\u4e0d\u5b8c\u5168\u8840\u6db2\u5b66\u6062\u590d\uff08CRi\/CRp\uff09\u3001\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u6216\u5f62\u6001\u5b66\u65e0\u767d\u8840\u75c5\u72b6\u6001\uff08MLFS\uff09\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\u3002<\/p>\n<p><b>\u5173\u4e8e\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08<\/b><b>AML<\/b><b>\uff09<\/b><\/p>\n<p>AML\u662f\u4e00\u79cd\u8840\u6db2\u548c\u9aa8\u9ad3\u764c\u75c7\uff0c\u75c5\u60c5\u8fdb\u5c55\u8fc5\u901f\uff0c\u662f\u6700\u5e38\u89c1\u7684\u6210\u4eba\u6025\u6027\u767d\u8840\u75c5\uff0c\u636e\u4f30\u8ba1\u7f8e\u56fd\u6bcf\u5e74\u7ea6\u67092\u4e07\u4f8b\u65b0\u53d1\u75c5\u4f8b\uff0c\u6b27\u6d32\u6bcf\u5e74\u7ea6\u67094.3\u4e07\u4f8b\u75c5\u4f8b<sup>[3],[4]<\/sup>\u3002\u5927\u591a\u6570AML\u60a3\u8005\u6700\u7ec8\u4f1a\u590d\u53d1\uff0c\u590d\u53d1\u6216\u96be\u6cbb\u6027AML\u9884\u540e\u8f83\u5dee<sup>[5]<\/sup>\u3002\u4e94\u5e74\u751f\u5b58\u7387\u7ea6\u4e3a27%\u3002\u7ea6\u67096%-10%\u7684AML\u60a3\u8005\u4e3aIDH1\u7a81\u53d8\uff0c\u7a81\u53d8\u7684IDH1\u9176\u963b\u65ad\u4e86\u6b63\u5e38\u7684\u9020\u8840\u5e72\u7ec6\u80de\u5206\u5316\uff0c\u4fc3\u8fdb\u4e86\u6025\u6027\u767d\u8840\u75c5\u7684\u53d1\u75c5<sup>[6]<\/sup>\u3002<\/p>\n<p><b>\u5173\u4e8e\u827e\u4f0f\u5c3c\u5e03\uff08<\/b><b>ivosidenib<\/b><b>\uff09<\/b><\/p>\n<p>\u827e\u4f0f\u5c3c\u5e03\u7528\u4e8e\u6cbb\u7597\u7ecf\u7f8e\u56fdFDA\u6279\u51c6\u7684\u68c0\u6d4b\u8bd5\u5242\u76d2\u786e\u5b9a\u643a\u5e26\u6613\u611f\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176-1\uff08IDH1\uff09\u7a81\u53d8\u7684\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u60a3\u8005\uff1a<\/p>\n<p><u>\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08<\/u><u>AML<\/u><u>\uff09<\/u><\/p>\n<ul type=\"disc\">\n<li>\u65b0\u8bca\u65ad\u7684\u226575\u5c81\u6216\u56e0\u5408\u5e76\u75c7\u65e0\u6cd5\u4f7f\u7528\u5f3a\u70c8\u8bf1\u5bfc\u5316\u7597\u7684AML\u6210\u4eba\u60a3\u8005\u3002 <\/li>\n<li>\u590d\u53d1\u6216\u96be\u6cbb\u6027AML\u3002<\/li>\n<\/ul>\n<p><u>\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c6\u7ba1\u764c<\/u><\/p>\n<ul type=\"disc\">\n<li>\u7ecf\u6cbb\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c6\u7ba1\u764c\u3002<\/li>\n<\/ul>\n<p><b>\u5173\u4e8e\u57fa\u77f3\u836f\u4e1a<\/b><\/p>\n<p>\u57fa\u77f3\u836f\u4e1a\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801: 2616\uff09\u662f\u4e00\u5bb6\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u7814\u7a76\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u521b\u65b0\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53ca\u7cbe\u51c6\u6cbb\u7597\u836f\u7269\uff0c\u4ee5\u6ee1\u8db3\u4e2d\u56fd\u548c\u5168\u7403\u764c\u75c7\u60a3\u8005\u7684\u6bb7\u5207\u533b\u7597\u9700\u6c42\u3002\u6210\u7acb\u4e8e2015\u5e74\u5e95\uff0c\u57fa\u77f3\u836f\u4e1a\u5df2\u96c6\u7ed3\u4e86\u4e00\u652f\u5728\u65b0\u836f\u7814\u53d1\u3001\u4e34\u5e8a\u7814\u7a76\u4ee5\u53ca\u5546\u4e1a\u8fd0\u8425\u65b9\u9762\u62e5\u6709\u4e30\u5bcc\u7ecf\u9a8c\u7684\u4e16\u754c\u7ea7\u7ba1\u7406\u56e2\u961f\u3002\u516c\u53f8\u4ee5\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u8054\u5408\u7597\u6cd5\u4e3a\u6838\u5fc3\uff0c\u5efa\u7acb\u4e86\u4e00\u676115\u79cd\u80bf\u7624\u5019\u9009\u836f\u7269\u7ec4\u6210\u7684\u4e30\u5bcc\u4ea7\u54c1\u7ba1\u7ebf\u3002\u76ee\u524d\uff0c\u57fa\u77f3\u836f\u4e1a\u5728\u5168\u7403\u8303\u56f4\u5185\u5df2\u7ecf\u83b7\u5f97\u4e86\u4e09\u4e2a\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u7684\u6279\u51c6\uff0c\u5206\u522b\u5728\u4e2d\u56fd\u5927\u9646\u83b7\u5f97\u4e24\u4e2a\u65b0\u836f\u4e0a\u5e02\u6279\u51c6\u3001\u5728\u53f0\u6e7e\u5730\u533a\u83b7\u5f97\u4e00\u4e2a\u65b0\u836f\u4e0a\u5e02\u6279\u51c6\u3002\u591a\u6b3e\u540e\u671f\u5019\u9009\u836f\u7269\u6b63\u5904\u4e8e\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u6216\u6ce8\u518c\u9636\u6bb5\u3002\u57fa\u77f3\u836f\u4e1a\u7684\u613f\u666f\u662f\u6210\u4e3a\u4eab\u8a89\u5168\u7403\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5f15\u9886\u653b\u514b\u764c\u75c7\u4e4b\u8def\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u6709\u5173\u57fa\u77f3\u836f\u4e1a\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\uff1a<a target=\"_blank\" href=\"http:\/\/www.cstonepharma.com\/\" rel=\"nofollow noopener\">www.cstonepharma.com<\/a>\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9648\u8ff0\u4ec5\u4e0e\u672c\u6587\u4f5c\u51fa\u8be5\u9648\u8ff0\u5f53\u65e5\u7684\u4e8b\u4ef6\u6216\u8d44\u6599\u6709\u5173\u3002\u9664\u6cd5\u5f8b\u89c4\u5b9a\u5916\uff0c\u4e8e\u4f5c\u51fa\u524d\u77bb\u6027\u9648\u8ff0\u5f53\u65e5\u4e4b\u540e\uff0c\u65e0\u8bba\u662f\u5426\u51fa\u73b0\u65b0\u8d44\u6599\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u51b5\uff0c\u6211\u4eec\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u6216\u516c\u5f00\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u53ca\u9884\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8bf7\u7ec6\u9605\u672c\u6587\uff0c\u5e76\u7406\u89e3\u6211\u4eec\u7684\u5b9e\u9645\u672a\u6765\u4e1a\u7ee9\u6216\u8868\u73b0\u53ef\u80fd\u4e0e\u9884\u671f\u6709\u91cd\u5927\u5dee\u5f02\u3002\u672c\u6587\u5185\u6240\u6709\u9648\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u53d1\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u6765\u53d1\u5c55\u800c\u51fa\u73b0\u53d8\u52a8\u3002<\/p>\n<p><b>\u53c2\u8003\u6587\u732e\uff1a<\/b><\/p>\n<div>\n<table id=\"convertedTable46ce\" cellspacing=\"0\" cellpadding=\"0\" border=\"0\" class=\"prnsbt0 prnsbr0 prnbcc prnsbb0 prnsbl0\">\n<tbody>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[1].<\/sup> Data on file. Servier. July 30, 2021<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[2].<\/sup> ClinicalTrials.gov. Study of AG-120 (Ivosidenib) vs. Placebo in Combination with Azacitidine in Patients With Previously Untreated Acute Myeloid Leukemia With an IDH1 Mutation (AGILE). Available at: <a target=\"_blank\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03173248\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03173248<\/a>. Accessed July 2021.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[3].<\/sup> National Cancer Institute Surveillance, Epidemiology, and End Results Program. Cancer Stat Facts: Acute Myeloid Leukemia (AML). https:\/\/seer.cancer.gov\/statfacts\/html\/amyl.html. Accessed July 2021.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[4].<\/sup> American Cancer Society. Acute Myeloid Leukemia (AML). <a target=\"_blank\" href=\"https:\/\/www.cancer.org\/content\/dam\/CRC\/PDF\/Public\/8674.00.pdf\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/www.cancer.org\/content\/dam\/CRC\/PDF\/Public\/8674.00.pdf<\/a>. Accessed July 2021.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[5].<\/sup> Kumar C. Genetic Abnormalities and Challenges in the Treatment of Acute Myeloid Leukemia. <i>Genes Cancer<\/i>. 2011; 2:95-107.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><sup>[6].<\/sup> DiNardo CD, Stein EM, de Botton S, <i>et al.<\/i> Durable Remissions from Ivosidenib in IDH1-Mutated Relapsed or Refractory AML. <i>N Engl J Med<\/i> 2018;378:2386-98.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>http:\/\/www.cstonepharma.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e0e\u5b89\u6170\u5242\u8054\u5408\u963f\u624e\u80de\u82f7\u76f8\u6bd4\uff0c\u827e\u4f0f\u5c3c\u5e03\u8054\u5408\u963f\u624e\u80de\u82f7\u5728\u5b8c\u5168\u7f13\u89e3\u7387\u3001\u5b8c\u5168\u7f13\u89e3\u548c\u5b8c\u5168\u7f13\u89e3\u4f34\u90e8\u5206\u8840\u6db2\u5b66\u6062\u590d\u7684\u7f13\u89e3\u7387\u3001\u4ee5\u53ca\u5ba2\u89c2\u7f13\u89e3\u7387\u65b9\u9762\u5b9e\u73b0\u663e\u8457\u6539\u5584 \u827e\u4f0f\u5c3c\u5e03\u8054\u5408\u963f\u624e\u80de\u82f7\u7684\u5b89\u5168\u6027\u7279\u5f81\u826f\u597d\uff0c\u4e0e\u6b64\u524d\u516c\u5e03\u6570\u636e\u4fdd\u6301\u4e00\u81f4 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20.5%\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0828.2% vs 16.4%\uff09\u3001\u4fbf\u79d8\uff0826.8% vs 52.1%\uff09\u548c\u80ba\u708e\uff0823.9% vs 31.5%\uff09\u3002 \u827e\u4f0f\u5c3c\u5e03\u5df2\u5728\u7f8e\u56fd\u83b7\u6279\uff0c\u7528\u4e8e\u5355\u836f\u6cbb\u7597IDH1\u7a81\u53d8\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027AML\u6210\u4eba\u60a3\u8005\uff0c\u4ee5\u53ca\u65b0\u8bca\u65ad\u7684\u5e74\u9f84\u226575\u5c81\u6216\u56e0\u5408\u5e76\u75c7\u65e0\u6cd5\u4f7f\u7528\u5f3a\u70c8\u8bf1\u5bfc\u5316\u7597\u7684IDH1\u7a81\u53d8AML\u6210\u4eba\u60a3\u8005\u3002\u8fd1\u671f\uff0c\u827e\u4f0f\u5c3c\u5e03\u5df2\u83b7\u6279\u51c6\u4f5c\u4e3a\u9996\u4e2a\u4e14\u552f\u4e00\u7528\u4e8e\u7ecf\u6cbbIDH1\u7a81\u53d8\u80c6\u7ba1\u764c\u60a3\u8005\u7684\u9776\u5411\u836f\u7269\u3002 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