{"id":56038,"date":"2021-12-10T15:00:00","date_gmt":"2021-12-10T08:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021121015000056038"},"modified":"2021-12-10T17:54:41","modified_gmt":"2021-12-10T09:54:41","slug":"%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9e%e5%9c%a82021%e5%b9%b4%e6%ac%a7%e6%b4%b2%e8%82%bf%e7%98%a4%e5%86%85%e7%a7%91%e5%ad%a6%e4%bc%9a%e5%85%8d%e7%96%ab%e8%82%bf%e7%98%a4%e5%ad%a6esmo-io%e5%a4%a7","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021121015000056038","title":{"rendered":"\u767e\u6d4e\u795e\u5dde\u57282021\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u514d\u75ab\u80bf\u7624\u5b66(ESMO IO)\u5927\u4f1a\u4e0a\u516c\u5e03\u767e\u6cfd\u5b89(R)\u9488\u5bf9\u9f3b\u54bd\u764c\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c"},"content":{"rendered":"<p><p><span class=\"xn-subheadline\">\u5728RATIONALE 309\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u767e\u6cfd\u5b89\u00ae\u8054\u5408\u5316\u7597\u663e\u8457\u5ef6\u957f\u4e86\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff0c\u5728\u5404\u60a3\u8005\u4e9a\u7ec4\u4e2d\u5747\u89c2\u5bdf\u5230\u4e86\u751f\u5b58\u83b7\u76ca<\/span><\/p>\n<p><span class=\"xn-subheadline\">\u8be5\u8054\u5408\u6cbb\u7597\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u6bcf\u79cd\u6cbb\u7597\u836f\u7269\u7684\u5df2\u77e5\u98ce\u9669\u4e00\u81f4<\/span><\/p>\n<p><span class=\"xn-subheadline\">\u57fa\u4e8e\u8be5\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7684\u671f\u4e2d\u5206\u6790\u79ef\u6781\u7ed3\u679c\uff0c\u5728\u4e2d\u56fd\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u76ee\u524d\u6b63\u5728\u5ba1\u8bc4\u8fc7\u7a0b\u4e2d<\/span><\/p>\n<p>\u4e2d\u56fd\u5317\u4eac\u548c\u7f8e\u56fd\u9ebb\u7701\u5251\u68652021\u5e7412\u670810\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u767e\u6d4e\u795e\u5dde\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff09\u662f\u4e00\u5bb6\u7acb\u8db3\u79d1\u5b66\u7684\u5168\u7403\u6027\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5728\u5168\u7403\u8303\u56f4\u5185\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u521b\u65b0\u836f\u7269\uff0c\u65e8\u5728\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u7ed3\u679c\u3001\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u516c\u53f8\u4eca\u65e5\u57282021\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u514d\u75ab\u80bf\u7624\u5b66\uff08ESMO IO\uff09\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86RATIONALE 309\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u8be5\u9879\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u8bc4\u4f30\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\uff08RM-NPC\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u5927\u4f1a\u4e8e2021\u5e7412\u67088\u65e5\u81f311\u65e5\u4e3e\u884c\u3002<\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u514d\u75ab\u80bf\u7624\u5b66\u9996\u5e2d\u533b\u5b66\u5b98\u8d32\u52c7\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u8054\u5408\u5316\u7597\u7684\u6cbb\u7597\u7ec4\u5408\u4e3aRM\u2013NPC\u60a3\u8005\u5e26\u6765\u4e86\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u83b7\u76ca\uff0c\u4e14\u4e0e\u5316\u7597\u76f8\u6bd4\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u3002\u57fa\u4e8e\u8be5\u7ed3\u679c\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u76ee\u524d\u6b63\u5728\u63a5\u53d7\u4e2d\u56fd\u836f\u76d1\u90e8\u95e8\u7684\u5ba1\u8bc4\u3002NPC\u4e3a\u4e2d\u56fd\u9ad8\u53d1\u764c\u79cd\uff0c\u5b58\u5728\u5927\u91cf\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42\u3002\u6211\u4eec\u671f\u5f85\u7ee7\u7eed\u4e0e\u836f\u76d1\u90e8\u95e8\u8fdb\u884c\u6c9f\u901a\uff0c\u5c3d\u65e9\u5c06\u8fd9\u4e00\u91cd\u8981\u7684\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u5e26\u7ed9\u4e2d\u56fd\u60a3\u8005\u3002\u201d&nbsp;<\/p>\n<p><span id=\"spanHghlta620\">\u57fa\u4e8eRATIONALE 309\u8bd5\u9a8c\u671f\u4e2d\u5206\u6790\u7ed3\u679c\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u4e8e2021\u5e748\u6708\u53d7\u7406\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u8054\u5408\u5316\u7597\u7528\u4e8eRM-NPC\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\uff08sBLA\uff09\u3002<\/span><\/p>\n<p><b>RATIONALE 309\u8bd5\u9a8c\u7ed3\u679c\uff1a\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u4f5c\u4e3aRM-NPC\u7684\u4e00\u7ebf\u6cbb\u7597<\/b><\/p>\n<p><i>\u4f18\u9009\u53e3\u5934\u62a5\u544a\uff1a<\/i><i>121O<\/i><\/p>\n<p>RATIONALE 309\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT03924986\uff09\uff0c\u65e8\u5728\u8bc4\u4f30\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u548c\u987a\u94c2\uff08A\u7ec4\uff09\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u548c\u987a\u94c2\uff08B\u7ec4\uff09\u4f5c\u4e3aRM\u2013NPC\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8be5\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRC\uff09\u6839\u636eRECIST 1.1\u7248\u6807\u51c6\u8bc4\u4f30\u7684\u610f\u5411\u6027\u6cbb\u7597\uff08ITT\uff09\u4eba\u7fa4\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff1b\u6b21\u8981\u7ec8\u70b9\u5305\u62ecIRC\u8bc4\u4f30\u7684\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u3001IRC\u8bc4\u4f30\u7684\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\u3001\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3001\u7814\u7a76\u8005\u8bc4\u4f30\u7684PFS\u3001\u81f3\u7b2c\u4e8c\u6b21\u5ba2\u89c2\u75be\u75c5\u8fdb\u5c55\u65f6\u95f4\uff08PFS2\uff09\u4ee5\u53ca\u5b89\u5168\u6027\u3002\u8bd5\u9a8c\u5171\u5165\u7ec4263\u4f8b\u60a3\u8005\uff0c\u5206\u522b\u6709131\u4f8b\u548c132\u4f8b\u60a3\u8005\u968f\u673a\u5206\u914d\u81f3A\u7ec4\u548cB\u7ec4\uff0c\u4e24\u7ec4\u60a3\u8005\u7684\u57fa\u7ebf\u7279\u5f81\u5747\u8861\u3002<\/p>\n<p>\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u6559\u6388\u3001\u8be5\u9879\u7814\u7a76\u7684\u4e3b\u8981\u52a9\u7406\u7814\u7a76\u8005\u6768\u4e91\u9e4f\u6559\u6388\u8868\u793a\uff1a\u201c\u5728RATIONALE 309\u8bd5\u9a8c\u4e2d\uff0c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u8054\u5408\u5316\u7597\u663e\u8457\u5ef6\u957f\u4e86\u65e2\u5f80\u672a\u7ecf\u6cbb\u7597\u7684RM-NPC\u60a3\u8005\u7684PFS\uff0c\u5728\u5404\u60a3\u8005\u4e9a\u7ec4\u4e2d\u89c2\u5bdf\u5230\u7684\u751f\u5b58\u83b7\u76ca\u4e00\u81f4\u3002RM-NPC\u662f\u4e9a\u6d32\u5e38\u89c1\u7684\u4fb5\u88ad\u6027\u5934\u9888\u90e8\u80bf\u7624\u3002\u4e24\u7ec4\u7684\u5b89\u5168\u6027\u7ed3\u679c\u5747\u4e0e\u5df2\u77e5\u98ce\u9669\u76f8\u4f3c\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u8fd9\u4e9b\u9f13\u821e\u4eba\u5fc3\u7684\u7ed3\u679c\u8bc1\u5b9e\u4e86\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u8054\u5408\u5316\u7597\u5728\u4e2d\u56fd\u4f5c\u4e3aRM-NPC\u4e00\u7ebf\u6cbb\u7597\u65b0\u6807\u51c6\u7597\u6cd5\u7684\u6f5c\u529b\u3002\u201d<\/p>\n<p>\u622a\u81f32021\u5e743\u670826\u65e5\uff0cRATIONALE 309\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a10\u4e2a\u6708\uff0c\u5728\u671f\u4e2d\u5206\u6790\u65f6\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\uff0c\u6839\u636eIRC\u7684\u8bc4\u4f30\uff0c\u4e0e\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u76f8\u6bd4\uff0c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u8054\u5408\u5316\u7597\u53ef\u6539\u5584PFS\uff0c\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u3002\u8bd5\u9a8c\u6709\u6548\u6027\u7ed3\u679c\u5982\u4e0b\uff1a&nbsp;<\/p>\n<ul type=\"disc\">\n<li>\u6839\u636eIRC\u7684\u8bc4\u4f30\uff0cA\u7ec4\u7684\u4e2d\u4f4dPFS\u4e3a9.2\u4e2a\u6708\uff0895% CI\uff1a7.6\uff0c10.1\uff09\uff0cB\u7ec4\u4e3a7.4\u4e2a\u6708\uff0895% CI\uff1a5.6\uff0c7.5\uff09\uff0c\u5206\u5c42\u98ce\u9669\u6bd4\uff08HR\uff09\u4e3a0.52\uff0895% CI\uff1a0.38\uff0c0.73\uff09\uff0c\u5206\u5c42log-rank\u68c0\u9a8cp\u503c&lt;&nbsp;0.0001\uff1b <\/li>\n<li>\u6839\u636eIRC\u7684\u8bc4\u4f30\uff0cA\u7ec4\u57286\u30019\u548c12\u4e2a\u6708\u65f6\u7684PFS\u7387\u5206\u522b\u4e3a66.1%\uff0895% CI\uff1a56.9\uff0c73.8\uff09\u300151.0%\uff0895% CI\uff1a41.1\uff0c60.1\uff09\u548c35.7%\uff0895% CI\uff1a25.2\uff0c46.4\uff09\uff0cB\u7ec4\u5206\u522b\u4e3a53.0%\uff0895% CI\uff1a43.4\uff0c61.8\uff09\u300121.6%\uff0895% CI\uff1a13.5\uff0c30.9\uff09\u548c12.2%\uff0895% CI\uff1a5.6\uff0c21.4\uff09\uff1b <\/li>\n<li>\u6839\u636e\u7814\u7a76\u8005\u7684\u8bc4\u4f30\uff0cA\u7ec4\u7684\u4e2d\u4f4dPFS\u4e3a9.8\u4e2a\u6708\uff0895% CI\uff1a7.8\uff0c11.9\uff09\uff0cB\u7ec4\u4e3a7.6\u4e2a\u6708\uff0895% CI\uff1a6.6\uff0c7.8\uff09\uff0c\u5206\u5c42HR\u4e3a0.54\uff0895% CI\uff1a0.38\uff0c0.76\uff09\uff1b <\/li>\n<li>\u5728\u5927\u591a\u6570\u4e9a\u7ec4\u4e2d\u89c2\u5bdf\u5230\u7684PFS\u83b7\u76ca\u4e00\u81f4\uff0c\u5305\u62ec\u75be\u75c5\u72b6\u6001\u3001\u57fa\u7ebf\u809d\u8f6c\u79fb\u548c\u6027\u522b\u4e9a\u7ec4\uff1b <\/li>\n<li>\u6839\u636eIRC\u7684\u8bc4\u4f30\uff0cA\u7ec4\u7684ORR\u548c\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u7387\u5206\u522b\u4e3a69.5%\u548c16.0%\uff0cB\u7ec4\u5206\u522b\u4e3a55.3%\u548c6.8%\uff1b <\/li>\n<li>\u6839\u636eIRC\u7684\u8bc4\u4f30\uff0cA\u7ec4\u7684\u4e2d\u4f4dDoR\u4e3a8.5\u4e2a\u6708\uff0895% CI\uff1a6.5\uff0c\u4e0d\u53ef\u4f30\u8ba1\uff09\uff0cB\u7ec4\u4e3a6.1\u4e2a\u6708\uff0895% CI\uff1a4.7\uff0c6.2\uff09\u3002<\/li>\n<\/ul>\n<p>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u8054\u5408\u5316\u7597\u7684\u5b89\u5168\u6027\u7279\u5f81\u53ef\u63a7\uff0c\u4e14\u4e0e\u6bcf\u79cd\u6cbb\u7597\u836f\u7269\u7684\u5df2\u77e5\u98ce\u9669\u4e00\u81f4\u3002\u8bd5\u9a8c\u5b89\u5168\u6027\u7ed3\u679c\u5982\u4e0b\uff1a<\/p>\n<ul type=\"disc\">\n<li>A\u7ec4\u7684\u6240\u6709\u60a3\u8005\uff08100%\uff09\u5747\u53d1\u751f\u81f3\u5c111\u4f8b\u4efb\u4f55\u7ea7\u522b\u7684\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\uff0c\u6700\u5e38\u89c1\u7684\uff08\u53d1\u751f\u7387\u2265&nbsp;20.0%\uff09\u4e3a\u8d2b\u8840\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u6076\u5fc3\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u964d\u4f4e\u3001\u98df\u6b32\u51cf\u9000\u3001\u5455\u5410\u3001\u4fbf\u79d8\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u76ae\u75b9\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\u3001\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08ALT\uff09\u5347\u9ad8\u3001\u4f4e\u94a0\u8840\u75c7\u3001\u8840\u808c\u9150\u5347\u9ad8\u3001\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08AST\uff09\u5347\u9ad8\u3001\u96be\u53d7\u548c\u53d1\u70ed\uff1b <\/li>\n<li>\u76f8\u6bd4\u4e4b\u4e0b\uff0cB\u7ec4\u4e2d\u6709131\u4f8b\u60a3\u8005\uff0899.2%\uff09\u53d1\u751f\u81f3\u5c111\u4f8b\u4efb\u4f55\u7ea7\u522b\u7684TEAE\uff0c\u6700\u5e38\u89c1\u7684\uff08\u53d1\u751f\u7387\u2265&nbsp;20.0%\uff09\u4e3a\u8d2b\u8840\u3001\u6076\u5fc3\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u964d\u4f4e\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u5455\u5410\u3001\u98df\u6b32\u51cf\u9000\u3001\u4fbf\u79d8\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u4f4e\u94a0\u8840\u75c7\u3001\u96be\u53d7\u3001\u4f4e\u94be\u8840\u75c7\u3001\u76ae\u75b9\u3001AST\u5347\u9ad8\u548c\u4f4e\u767d\u86cb\u767d\u8840\u75c7\uff1b <\/li>\n<li>A\u7ec4\u4e2d\u6709106\u4f8b\u60a3\u8005\uff0880.9%\uff09\u53d1\u751f\u4e86\u2265&nbsp;3\u7ea7TEAE\uff0cB\u7ec4\u4e2d\u6709108\u4f8b\u60a3\u8005\uff0881.8%\uff09\u53d1\u751f\u4e86\u2265&nbsp;3\u7ea7TEAE\uff1b <\/li>\n<li>A\u7ec4\u4e2d\u670936\u4f8b\u60a3\u8005\uff0827.5%\uff09\u53d1\u751f\u4e86\u4e25\u91cdTEAE\uff0cB\u7ec4\u4e2d\u670944\u4f8b\u60a3\u8005\uff0833.3%\uff09\u53d1\u751f\u4e86\u4e25\u91cdTEAE\uff1b <\/li>\n<li>A\u7ec4\u4e2d\u5206\u522b\u67092\u4f8b\u60a3\u8005\uff081.5%\uff09\u548c5\u4f8b\u60a3\u8005\uff083.8%\uff09\u53d1\u751f\u4e86\u5bfc\u81f4\u6c38\u4e45\u7ec8\u6b62\u6cbb\u7597\u548c\u6b7b\u4ea1\u7684TEAE\uff0cB\u7ec4\u4e2d\u5206\u522b\u67093\u4f8b\u60a3\u8005\uff082.3%\uff09\u548c2\u4f8b\u60a3\u8005\uff081.5%\uff09\u53d1\u751f\u4e86\u5bfc\u81f4\u6c38\u4e45\u7ec8\u6b62\u6cbb\u7597\u548c\u6b7b\u4ea1\u7684TEAE\uff1b <\/li>\n<li>A\u7ec4\u4e2d\u670924\u4f8b\u60a3\u8005\uff0818.3%\uff09\u53d1\u751f\u81f3\u5c111\u4f8b\u4efb\u4f55\u7ea7\u522b\u7684\u514d\u75ab\u4ecb\u5bfc\u6027TEAE\uff0c\u5176\u4e2d3\u4f8b\u60a3\u8005\uff082.3%\uff09\u53d1\u751f\u4e86\u2265&nbsp;3\u7ea7\u4e8b\u4ef6\u3002<\/li>\n<\/ul>\n<p><b>\u5173\u4e8e\u9f3b\u54bd\u764c<\/b><\/p>\n<p>\u9f3b\u54bd\u764c\uff08NPC\uff09\u662f\u4e00\u79cd\u6076\u6027\u9cde\u72b6\u7ec6\u80de\u764c\uff0c\u8d77\u6e90\u4e8e\u9f3b\u54bd\u7684\u4e0a\u76ae\u7ec6\u80de\uff0c\u6700\u5e38\u89c1\u4e8e\u54bd\u9690\u7a9d<sup>1<\/sup>\u30022020\u5e74\uff0c\u4e2d\u56fd\u7ea6\u670962,555\u4f8b\u65b0\u589eNPC\u60a3\u8005\uff0c\u5360\u5168\u7403\u65b0\u53d1\u75c5\u4f8b\u768446.8%<sup>2<\/sup>\u3002\u5c3d\u7ba1NPC\u5bf9\u4e2d\u56fd\u5357\u65b9\u548c\u5176\u4ed6\u75be\u75c5\u6d41\u884c\u5730\u533a\u7684\u516c\u5171\u536b\u751f\u9020\u6210\u4e86\u6c89\u91cd\u8d1f\u62c5\uff0c\u4f46\u5927\u4f17\u5bf9NPC\u7684\u75c5\u56e0\u4ee5\u53ca\u5982\u4f55\u9884\u9632\u77e5\u4e4b\u8f83\u5c11<sup>3<\/sup>\u3002NPC\u7684\u4e3b\u8981\u98ce\u9669\u56e0\u7d20\u662f\u9057\u4f20\u6613\u611f\u6027\u3001Epstein-Barr\u75c5\u6bd2\uff08EBV\uff09\u611f\u67d3\u548c\u98df\u7528\u76d0\u814c\u98df\u7269<sup>4<\/sup>\u3002\u665a\u671fNPC\u60a3\u8005\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u7ea6\u4e3a20\u4e2a\u6708<sup>5<\/sup>\uff1b\u636e\u62a5\u9053\uff0c\u590d\u53d1\u6216\u8f6c\u79fb\u6027NPC\u60a3\u8005\u7684\u9884\u540e\u901a\u5e38\u9010\u6e10\u6076\u5316\uff0c3\u5e74\u751f\u5b58\u7387\u964d\u81f3\u7ea67% ~ 40%\uff0c\u8fd9\u8868\u660eNPC\u4ecd\u5b58\u5728\u5927\u91cf\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\uff0c\u4e9f\u9700\u66f4\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5&nbsp;<sup>6,7,8<\/sup>\u3002<\/p>\n<p><b>\u5173\u4e8e\u767e\u6cfd\u5b89<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09<\/b><\/p>\n<p>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u662f\u4e00\u6b3e\u4eba\u6e90\u5316IgG4\u6297\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53-1\uff08PD-1\uff09\u5355\u514b\u9686\u6297\u4f53\uff0c\u8bbe\u8ba1\u76ee\u7684\u662f\u4e3a\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u4e0e\u5de8\u566c\u7ec6\u80de\u4e2d\u7684Fc\u03b3\u53d7\u4f53\u7ed3\u5408\u3002\u4e34\u5e8a\u524d\u6570\u636e\u8868\u660e\uff0c\u5de8\u566c\u7ec6\u80de\u4e2d\u7684Fc\u03b3\u53d7\u4f53\u7ed3\u5408\u4e4b\u540e\u4f1a\u6fc0\u6d3b\u6297\u4f53\u4f9d\u8d56\u7ec6\u80de\u4ecb\u5bfc\u6740\u4f24T\u7ec6\u80de\uff0c\u4ece\u800c\u964d\u4f4e\u4e86PD-1\u6297\u4f53\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u662f\u7b2c\u4e00\u6b3e\u7531\u767e\u6d4e\u795e\u5dde\u7684\u514d\u75ab\u80bf\u7624\u751f\u7269\u5e73\u53f0\u7814\u53d1\u7684\u836f\u7269\uff0c\u76ee\u524d\u6b63\u8fdb\u884c\u5355\u836f\u53ca\u8054\u5408\u7597\u6cd5\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u5f00\u53d1\u4e00\u7cfb\u5217\u9488\u5bf9\u5b9e\u4f53\u7624\u548c\u8840\u6db2\u80bf\u7624\u7684\u5e7f\u6cdb\u9002\u5e94\u75c7\u3002<\/p>\n<p>\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u5df2\u6279\u51c6\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7528\u4e8e\u4e94\u9879\u9002\u5e94\u75c7\uff0c\u5305\u62ec\u5b8c\u5168\u6279\u51c6\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u8054\u5408\u5316\u7597\u7528\u4e8e\u6cbb\u7597\u4e00\u7ebf\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u548c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u8054\u5408\u5316\u7597\u7528\u4e8e\u6cbb\u7597\u4e00\u7ebf\u665a\u671f\u975e\u9cde\u72b6NSCLC\u60a3\u8005\uff0c\u4ee5\u53ca\u9644\u6761\u4ef6\u6279\u51c6\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7528\u4e8e\u6cbb\u7597\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08cHL\uff09\u60a3\u8005\u3001PD-L1\u9ad8\u8868\u8fbe\u7684\u542b\u94c2\u5316\u7597\u5931\u8d25\u5305\u62ec\u65b0\u8f85\u52a9\u6216\u8f85\u52a9\u5316\u759712\u4e2a\u6708\u5185\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\uff08UC\uff09\u60a3\u8005\uff0c\u4ee5\u53ca\u81f3\u5c11\u7ecf\u8fc7\u4e00\u79cd\u5168\u8eab\u6cbb\u7597\u7684\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u60a3\u8005\u3002\u9488\u5bf9\u4e0a\u8ff0\u4e09\u9879\u9644\u6761\u4ef6\u83b7\u6279\u9002\u5e94\u75c7\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u6b63\u5728\u8fdb\u884c\u7684\u786e\u8bc1\u6027\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u56db\u9879\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u6b63\u5728\u63a5\u53d7NMPA\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u7684\u5ba1\u8bc4\uff0c\u5305\u62ec\u4e00\u9879\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u94c2\u7c7b\u5316\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u4e8c\u6216\u4e09\u7ebf\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u3001\u4e00\u9879\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7ecf\u6cbb\u3001\u5c40\u90e8\u665a\u671f\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ad8\u5ea6\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u578b\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u578b\uff08dMMR\uff09\u5b9e\u4f53\u7624\u60a3\u8005\u3001\u4e00\u9879\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e00\u7ebf\u6807\u51c6\u5316\u7597\u540e\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\uff08ESCC\uff09\u60a3\u8005\u548c\u4e00\u9879\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\uff08NPC\uff09\u60a3\u8005\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n<p>\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u53d7\u7406\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7ecf\u7cfb\u7edf\u6cbb\u7597\u540e\u4e0d\u53ef\u5207\u9664\u3001\u590d\u53d1\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u3002\u6839\u636e\u300a\u5904\u65b9\u836f\u4f7f\u7528\u8005\u4ed8\u8d39\u6cd5\u6848\u300b\uff08PDUFA\uff09\uff0cFDA\u5bf9\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u4e0a\u5e02\u7533\u8bf7\u505a\u51fa\u51b3\u8bae\u7684\u76ee\u6807\u65e5\u671f\u4e3a2022\u5e747\u670812\u65e5\u3002<\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u5df2\u5728\u4e2d\u56fd\u548c\u5168\u7403\u8303\u56f4\u5185\u5f00\u5c55\u6216\u5b8c\u6210\u4e8617\u9879\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7684\u6ce8\u518c\u6027\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u4e2d\u5305\u62ec13\u98793\u671f\u4e34\u5e8a\u8bd5\u9a8c\u548c4\u9879\u5173\u952e\u60272\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p>2021\u5e741\u6708\uff0c\u767e\u6d4e\u795e\u5dde\u4e0e\u8bfa\u534e\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u6388\u6743\u8bfa\u534e\u5728\u5317\u7f8e\u3001\u6b27\u6d32\u548c\u65e5\u672c\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u3002<\/p>\n<p>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u4ee5\u5916\u56fd\u5bb6\u6216\u5730\u533a\u5c1a\u672a\u83b7\u6279\u3002<\/p>\n<p><b>\u5173\u4e8e\u767e\u6cfd\u5b89<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u7684\u4e34\u5e8a\u7814\u53d1\u9879\u76ee<\/b><\/p>\n<p>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u591a\u897f\u4ed6\u8d5b\u7528\u4e8e\u4e8c\u7ebf\u6216\u4e09\u7ebf\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5b89\u5168\u6027\u6709\u6548\u6027\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03358875\uff09\uff1b <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u6551\u63f4\u6027\u5316\u7597\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04486391\uff09 <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03967977\uff09 <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03594747\uff09\uff1b <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03663205\uff09\uff1b <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u542b\u94c2\u53cc\u836f\u5316\u7597\u7528\u4e8e\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04379635\uff09\uff1b <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\/\u5b89\u6170\u5242\u8054\u5408\u94c2\u7c7b\u836f\u7269\u548c\u4f9d\u6258\u6cca\u82f7\u7528\u4e8e\u6cbb\u7597\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04005716\uff09 <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u809d\u7ec6\u80de\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03412773\uff09\uff1b <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7ecf\u6cbb\u60a3\u8005\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03419897\uff09\uff1b <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u8180\u80f1\u764c\u60a3\u8005\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT04004221\uff09 <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u5316\u7597\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03430843\uff09\uff1b <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03783442\uff09\uff1b <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u540c\u6b65\u653e\u5316\u7597\u7528\u4e8e\u6cbb\u7597\u5c40\u9650\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03957590\uff09\uff1b <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u80c3\u764c\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03777657\uff09 <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03209973\uff09 <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597MSI-H\u6216dMMR\u5b9e\u4f53\u7624\u60a3\u8005\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03736889\uff09 <\/li>\n<li>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u9f3b\u54bd\u764c\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1aNCT03924986\uff09<\/li>\n<\/ul>\n<p><b>\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66<\/b><\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u6216\u4e0e\u5fd7\u540c\u9053\u5408\u7684\u5408\u4f5c\u4f19\u4f34\u643a\u624b\uff0c\u4e0d\u65ad\u63a8\u52a8\u540c\u7c7b\u6700\u4f73\u6216\u540c\u7c7b\u7b2c\u4e00\u7684\u4e34\u5e8a\u5019\u9009&nbsp;\u836f\u7269\u7814\u53d1\uff0c\u81f4\u529b\u4e8e\u4e3a\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u6709\u5f71\u54cd\u529b\u3001\u53ef\u53ca\u4e14\u53ef\u8d1f\u62c5\u7684\u836f\u7269\u3002\u516c\u53f8\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u548c\u5f00\u53d1\u56e2&nbsp;\u961f\u5df2\u6709\u7ea6 2,750 \u4eba\uff0c\u56e2\u961f\u89c4\u6a21\u8fd8\u5728\u4e0d\u65ad\u6269\u5927\u3002\u8fd9\u652f\u56e2\u961f\u8ba1\u5212\u6216\u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u56f4\u652f\u6301\u5f00\u5c55\u8d85\u8fc7 90 \u9879\u4e34\u5e8a\u7814\u7a76\uff0c\u5df2\u62db\u52df\u60a3\u8005\u548c\u5065\u5eb7\u5fd7\u613f\u8005\u8d85\u8fc7 14,000 \u4eba\u3002\u767e\u6d4e\u795e\u5dde\u81ea\u6709\u7684\u4e34\u5e8a\u5f00\u53d1\u56e2\u961f\u89c4\u5212\u5e76\u4e3b\u5bfc\u516c\u53f8\u4ea7&nbsp;\u54c1\u7ba1\u7ebf\u7684\u7814\u53d1\u548c\u6269\u5145\uff0c\u4e3a\u8986\u76d6\u5168\u7403\u8d85\u8fc7 45 \u4e2a\u56fd\u5bb6\/\u5730\u533a\u7684\u4e34\u5e8a\u8bd5\u9a8c\u63d0\u4f9b\u652f\u6301\u548c\u6307\u5bfc\u3002\u516c\u53f8\u7279\u522b\u5173&nbsp;\u6ce8\u8840\u6db2\u80bf\u7624\u548c\u5b9e\u4f53\u80bf\u7624\u7684\u9776\u5411\u6cbb\u7597\u53ca\u80bf\u7624\u514d\u75ab\u6cbb\u7597\uff0c\u5e76\u91cd\u70b9\u7814\u7a76\u5355\u836f\u548c\u8054\u5408\u7597\u6cd5\u3002\u76ee\u524d\uff0c\u767e\u6d4e\u795e&nbsp;\u5dde\u81ea\u4e3b\u7814\u53d1\u7684\u4e09\u6b3e\u836f\u7269\u5df2\u83b7\u6279\u4e0a\u5e02\uff1a\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\uff08BTK\u6291\u5236\u5242\uff0c\u5df2\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u6b27\u76df\u3001\u52a0\u62ff\u5927\u3001\u6fb3\u5927\u5229\u4e9a\u53ca\u5176\u4ed6\u56fd\u9645\u5e02\u573a\u83b7\u6279\u4e0a\u5e02\uff09\uff1b\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\uff08\u53ef\u6709\u6548\u907f\u514d FC-\u03b3\u53d7\u4f53\u7ed3\u5408\u7684\u6297 PD-1 \u6297\u4f53\uff0c\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff09\u4ee5\u53ca\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\uff08PARP \u6291\u5236\u5242\uff0c\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff09\u3002<\/p>\n<p>\u540c\u65f6\uff0c\u767e\u6d4e\u795e\u5dde\u8fd8\u4e0e\u5176\u4ed6\u521b\u65b0\u516c\u53f8\u5408\u4f5c\uff0c\u5171\u540c\u643a\u624b\u63a8\u8fdb\u521b\u65b0\u7597\u6cd5\u7684\u7814\u53d1\uff0c\u4ee5\u6ee1\u8db3\u5168\u7403\u5065\u5eb7\u9700\u6c42\u3002&nbsp;\u5728\u4e2d\u56fd\uff0c\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u9500\u552e\u591a\u6b3e\u7531\u5b89\u8fdb\u548c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u6388\u6743\u7684\u80bf\u7624\u836f\u7269\u3002\u516c\u53f8\u4e5f\u901a\u8fc7\u4e0e\u5305\u62ec\u5b89\u8fdb\u3001&nbsp;\u767e\u5965\u6cf0\u3001EUSA Pharma\u3001Mirati Therapeutics\u3001Seagen \u4ee5\u53ca&nbsp;Zymeworks \u5728\u5185\u7684\u591a\u5bb6\u516c\u53f8\u5408\u4f5c\uff0c&nbsp;\u66f4\u5927\u7a0b\u5ea6\u6ee1\u8db3\u5f53\u524d\u5168\u7403\u8303\u56f4\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002\u767e\u6d4e\u795e\u5dde\u8fd8\u4e0e\u8bfa\u534e\u516c\u53f8\u8fbe\u6210\u5408\u4f5c\uff0c\u6388\u6743\u8bfa\u534e&nbsp;\u5728\u5317\u7f8e\u3001\u6b27\u6d32\u548c\u65e5\u672c\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u3002<\/p>\n<p><b>\u5173\u4e8e\u767e\u6d4e\u795e\u5dde<\/b><\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u662f\u4e00\u5bb6\u7acb\u8db3\u4e8e\u79d1\u5b66\u7684\u5168\u7403\u6027\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u521b\u65b0\u3001\u53ef\u8d1f\u62c5\u7684\u836f\u7269\uff0c\u65e8\u5728\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u6548\u679c\u3001\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u76ee\u524d\u516c\u53f8\u5e7f\u6cdb\u7684\u836f\u7269\u7ec4\u5408\u5305\u62ec40\u591a\u6b3e\u4e34\u5e8a\u5019\u9009\u836f\u7269\u3002\u516c\u53f8\u901a\u8fc7\u52a0\u5f3a\u81ea\u4e3b\u7814\u53d1\u80fd\u529b\u548c\u5408\u4f5c\uff0c\u52a0\u901f\u63a8\u8fdb\u591a\u5143\u3001\u521b\u65b0\u7684\u836f\u7269\u7ba1\u7ebf\u5f00\u53d1\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u57282030\u5e74\u524d\u4e3a\u5168\u740320\u591a\u4ebf\u4eba\u5168\u9762\u6539\u5584\u836f\u7269\u53ef\u53ca\u6027\u3002\u767e\u6d4e\u795e\u5dde\u5728\u5168\u7403\u4e94\u5927\u6d32\u6253\u9020\u4e86\u4e00\u652f\u8d85\u8fc77,700\u4eba\u7684\u56e2\u961f\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a target=\"_blank\" href=\"http:\/\/www.beigene.com.cn\/\" rel=\"nofollow noopener\">http:\/\/www.beigene.com.cn<\/a>\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u6839\u636e\u300a1995\u5e74\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 1995\uff09\u4ee5\u53ca\u5176\u4ed6\u8054\u90a6\u8bc1\u5238\u6cd5\u5f8b\u4e2d\u5b9a\u4e49\u7684\u524d\u77bb\u6027\u58f0\u660e\uff0c\u5305\u62ec\u6709\u5173\u767e\u6d4e\u795e\u5dde\u5bf9\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u7528\u4e8e\u6cbb\u7597NPC\u7684\u5f00\u53d1\u3001\u6f5c\u5728\u6ce8\u518c\u5ba1\u6279\u548c\u5546\u4e1a\u5316\u7684\u8ba1\u5212\u3001\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u8054\u5408\u5316\u7597\u4f5c\u4e3aRM-NPC\u4e00\u7ebf\u6cbb\u7597\u65b0\u6807\u51c6\u7597\u6cd5\u7684\u6f5c\u529b\u7684\u58f0\u660e\uff0c\u6709\u5173\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u548c\u5176\u4ed6\u5730\u533a\u6b63\u5728\u8fdb\u884c\u7684\u548c\u672a\u6765\u7684\u4e34\u5e8a\u5f00\u53d1\u548c\u6f5c\u5728\u6ce8\u518c\u5ba1\u6279\u7684\u58f0\u660e\uff0c\u4ee5\u53ca\u5728\u201c\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66\u201d\u548c\u201c\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u201d\u526f\u6807\u9898\u4e0b\u63d0\u53ca\u7684\u767e\u6d4e\u795e\u5dde\u8ba1\u5212\u3001\u627f\u8bfa\u3001\u62b1\u8d1f\u548c\u76ee\u6807\u3002\u7531\u4e8e\u5404\u79cd\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u58f0\u660e\u6709\u91cd\u5927\u5dee\u5f02\u3002\u8fd9\u4e9b\u56e0\u7d20\u5305\u62ec\u4e86\u4ee5\u4e0b\u4e8b\u9879\u7684\u98ce\u9669\uff1a\u767e\u6d4e\u795e\u5dde\u8bc1\u660e\u5176\u5019\u9009\u836f\u7269\u529f\u6548\u548c\u5b89\u5168\u6027\u7684\u80fd\u529b\uff1b\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u7ed3\u679c\u53ef\u80fd\u4e0d\u652f\u6301\u8fdb\u4e00\u6b65\u5f00\u53d1\u6216\u4e0a\u5e02\u5ba1\u6279\uff1b\u836f\u653f\u90e8\u95e8\u7684\u884c\u52a8\u53ef\u80fd\u4f1a\u5f71\u54cd\u5230\u4e34\u5e8a\u8bd5\u9a8c\u7684\u542f\u52a8\u3001\u65f6\u95f4\u8868\u548c\u8fdb\u5c55\u4ee5\u53ca\u836f\u7269\u4e0a\u5e02\u5ba1\u6279\uff1b\u767e\u6d4e\u795e\u5dde\u7684\u4e0a\u5e02\u836f\u7269\u53ca\u5019\u9009\u836f\u7269\uff08\u5982\u80fd\u83b7\u6279\uff09\u83b7\u5f97\u5546\u4e1a\u6210\u529f\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u83b7\u5f97\u548c\u7ef4\u62a4\u5bf9\u5176\u836f\u7269\u548c\u6280\u672f\u7684\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u4f9d\u8d56\u7b2c\u4e09\u65b9\u8fdb\u884c\u836f\u7269\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5176\u4ed6\u670d\u52a1\u7684\u60c5\u51b5\uff1b\u767e\u6d4e\u795e\u5dde\u53d6\u5f97\u76d1\u7ba1\u5ba1\u6279\u548c\u5546\u4e1a\u5316\u533b\u836f\u4ea7\u54c1\u7684\u6709\u9650\u7ecf\u9a8c\uff0c\u53ca\u5176\u83b7\u5f97\u8fdb\u4e00\u6b65\u7684\u8425\u8fd0\u8d44\u91d1\u4ee5\u5b8c\u6210\u5019\u9009\u836f\u7269\u5f00\u53d1\u548c\u5b9e\u73b0\u5e76\u4fdd\u6301\u76c8\u5229\u7684\u80fd\u529b\uff1b\u65b0\u51a0\u80ba\u708e\u5168\u7403\u5927\u6d41\u884c\u5bf9\u767e\u6d4e\u795e\u5dde\u7684\u4e34\u5e8a\u5f00\u53d1\u3001\u76d1\u7ba1\u3001\u5546\u4e1a\u5316\u8fd0\u8425\u4ee5\u53ca\u5176\u4ed6\u4e1a\u52a1\u5e26\u6765\u7684\u5f71\u54cd\uff1b\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5728\u6700\u8fd1\u5b63\u5ea6\u62a5\u544a\u768410-Q\u8868\u683c\u4e2d\u201c\u98ce\u9669\u56e0\u7d20\u201d\u7ae0\u8282\u91cc\u66f4\u5168\u9762\u8ba8\u8bba\u7684\u5404\u7c7b\u98ce\u9669\uff1b\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u671f\u540e\u5448\u62a5\u4e2d\u5173\u4e8e\u6f5c\u5728\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8ba8\u8bba\u3002\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u4ec5\u53ca\u4e8e\u65b0\u95fb\u7a3f\u53d1\u5e03\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6d4e\u795e\u5dde\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u8be5\u7b49\u4fe1\u606f\u3002<\/p>\n<p><b>\u53c2\u8003\u6587\u732e<\/b><\/p>\n<p>1.&nbsp;Yu, M. C., &amp; Yuan, J.-M. (2002). Epidemiology of nasopharyngeal carcinoma. Seminars in Cancer Biology, 12(6), 421\u2013429. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/s1044579x02000858\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1016\/s1044579x02000858<\/a>.<\/p>\n<p>2. Globocan 2020. Available at <a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf\" rel=\"nofollow\">https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf<\/a>. Access <span class=\"xn-chron\">July 2021<\/span>.<\/p>\n<p>3. Wu, L., Li, C., &amp; Pan, L. (2018). Nasopharyngeal carcinoma: A review of current updates. Experimental and Therapeutic Medicine, 15(4), 3687\u20133692. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.3892\/etm.2018.5878\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.3892\/etm.2018.5878<\/a>.<\/p>\n<p>4.&nbsp;Liu, Y.-T., Dai, J.-J., Xu, C.-H., Lu, Y.-K., Fan, Y.-Y., Zhang, X.-L., Zhang, C.-X., &amp; Chen, Y.-M. (2012). Greater intake of fruit and vegetables is associated with lower risk of nasopharyngeal carcinoma in Chinese adults: A case-control study. Cancer Causes &amp; Control: CCC, 23(4), 589\u2013599. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1007\/s10552-012-9923-z\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1007\/s10552-012-9923-z<\/a>.<\/p>\n<p>5.&nbsp;Perri, F., (2019). Management of recurrent nasopharyngeal carcinoma: current perspectives. Onco Targets Ther, 12, 1583-1591. doi:10.2147\/OTT.S188148.<\/p>\n<p>6.&nbsp;Li, J.-X., Huang, S.-M., Wen, B.-X., &amp; Lu, T.-X. (2014). Prognostic factors on overall survival of newly diagnosed metastatic nasopharyngeal carcinoma. Asian Pacific Journal of Cancer Prevention: APJCP, 15(7), 3169\u20133173. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.7314\/apjcp.2014.15.7.3169\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.7314\/apjcp.2014.15.7.3169<\/a>.<\/p>\n<p>7.&nbsp;Toumi, N., Ennouri, S., Charfeddine, I., Daoud, J., &amp; Khanfir, A. (2020). Prognostic factors in metastatic nasopharyngeal carcinoma. Brazilian Journal of Otorhinolaryngology. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/j.bjorl.2020.05.022\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1016\/j.bjorl.2020.05.022<\/a>.<\/p>\n<p>8.&nbsp;Xu, Y., Huang, T., Mao, M., Zhai, J., &amp; Chen, J. (2020). Metastatic Patterns and Prognosis of de novo Metastatic Nasopharyngeal Carcinoma in <span class=\"xn-location\">the United States<\/span>. The Laryngoscope. <a target=\"_blank\" href=\"https:\/\/doi.org\/10.1002\/lary.28983\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1002\/lary.28983<\/a>. <\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>http:\/\/www.beigene.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5728RATIONALE 309\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u767e\u6cfd\u5b89\u00ae\u8054\u5408\u5316\u7597\u663e\u8457\u5ef6\u957f\u4e86\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff0c\u5728\u5404\u60a3\u8005\u4e9a\u7ec4\u4e2d\u5747\u89c2\u5bdf\u5230\u4e86\u751f\u5b58\u83b7\u76ca \u8be5\u8054\u5408\u6cbb\u7597\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u6bcf\u79cd\u6cbb\u7597\u836f\u7269\u7684\u5df2\u77e5\u98ce\u9669\u4e00\u81f4 \u57fa\u4e8e\u8be5\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7684\u671f\u4e2d\u5206\u6790\u79ef\u6781\u7ed3\u679c\uff0c\u5728\u4e2d\u56fd\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u76ee\u524d\u6b63\u5728\u5ba1\u8bc4\u8fc7\u7a0b\u4e2d \u4e2d\u56fd\u5317\u4eac\u548c\u7f8e\u56fd\u9ebb\u7701\u5251\u68652021\u5e7412\u670810\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u767e\u6d4e\u795e\u5dde\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff09\u662f\u4e00\u5bb6\u7acb\u8db3\u79d1\u5b66\u7684\u5168\u7403\u6027\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5728\u5168\u7403\u8303\u56f4\u5185\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u521b\u65b0\u836f\u7269\uff0c\u65e8\u5728\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u7ed3\u679c\u3001\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u516c\u53f8\u4eca\u65e5\u57282021\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u514d\u75ab\u80bf\u7624\u5b66\uff08ESMO IO\uff09\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86RATIONALE 309\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u8be5\u9879\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u8bc4\u4f30\u767e\u6cfd\u5b89&reg;\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\uff08RM-NPC\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u5927\u4f1a\u4e8e2021\u5e7412\u67088\u65e5\u81f311\u65e5\u4e3e\u884c\u3002 \u767e\u6d4e\u795e\u5dde\u514d\u75ab\u80bf\u7624\u5b66\u9996\u5e2d\u533b\u5b66\u5b98\u8d32\u52c7\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u767e\u6cfd\u5b89&reg;\u8054\u5408\u5316\u7597\u7684\u6cbb\u7597\u7ec4\u5408\u4e3aRM\u2013NPC\u60a3\u8005\u5e26\u6765\u4e86\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u83b7\u76ca\uff0c\u4e14\u4e0e\u5316\u7597\u76f8\u6bd4\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u3002\u57fa\u4e8e\u8be5\u7ed3\u679c\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u76ee\u524d\u6b63\u5728\u63a5\u53d7\u4e2d\u56fd\u836f\u76d1\u90e8\u95e8\u7684\u5ba1\u8bc4\u3002NPC\u4e3a\u4e2d\u56fd\u9ad8\u53d1\u764c\u79cd\uff0c\u5b58\u5728\u5927\u91cf\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42\u3002\u6211\u4eec\u671f\u5f85\u7ee7\u7eed\u4e0e\u836f\u76d1\u90e8\u95e8\u8fdb\u884c\u6c9f\u901a\uff0c\u5c3d\u65e9\u5c06\u8fd9\u4e00\u91cd\u8981\u7684\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u5e26\u7ed9\u4e2d\u56fd\u60a3\u8005\u3002\u201d&nbsp; \u57fa\u4e8eRATIONALE 309\u8bd5\u9a8c\u671f\u4e2d\u5206\u6790\u7ed3\u679c\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u4e8e2021\u5e748\u6708\u53d7\u7406\u767e\u6cfd\u5b89&reg;\u8054\u5408\u5316\u7597\u7528\u4e8eRM-NPC\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\uff08sBLA\uff09\u3002 RATIONALE 309\u8bd5\u9a8c\u7ed3\u679c\uff1a\u767e\u6cfd\u5b89&reg;\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u4f5c\u4e3aRM-NPC\u7684\u4e00\u7ebf\u6cbb\u7597 \u4f18\u9009\u53e3\u5934\u62a5\u544a\uff1a121O RATIONALE 309\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT03924986\uff09\uff0c\u65e8\u5728\u8bc4\u4f30\u767e\u6cfd\u5b89&reg;\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u548c\u987a\u94c2\uff08A\u7ec4\uff09\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u548c\u987a\u94c2\uff08B\u7ec4\uff09\u4f5c\u4e3aRM\u2013NPC\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8be5\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRC\uff09\u6839\u636eRECIST 1.1\u7248\u6807\u51c6\u8bc4\u4f30\u7684\u610f\u5411\u6027\u6cbb\u7597\uff08ITT\uff09\u4eba\u7fa4\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff1b\u6b21\u8981\u7ec8\u70b9\u5305\u62ecIRC\u8bc4\u4f30\u7684\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u3001IRC\u8bc4\u4f30\u7684\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\u3001\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3001\u7814\u7a76\u8005\u8bc4\u4f30\u7684PFS\u3001\u81f3\u7b2c\u4e8c\u6b21\u5ba2\u89c2\u75be\u75c5\u8fdb\u5c55\u65f6\u95f4\uff08PFS2\uff09\u4ee5\u53ca\u5b89\u5168\u6027\u3002\u8bd5\u9a8c\u5171\u5165\u7ec4263\u4f8b\u60a3\u8005\uff0c\u5206\u522b\u6709131\u4f8b\u548c132\u4f8b\u60a3\u8005\u968f\u673a\u5206\u914d\u81f3A\u7ec4\u548cB\u7ec4\uff0c\u4e24\u7ec4\u60a3\u8005\u7684\u57fa\u7ebf\u7279\u5f81\u5747\u8861\u3002 \u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u6559\u6388\u3001\u8be5\u9879\u7814\u7a76\u7684\u4e3b\u8981\u52a9\u7406\u7814\u7a76\u8005\u6768\u4e91\u9e4f\u6559\u6388\u8868\u793a\uff1a\u201c\u5728RATIONALE 309\u8bd5\u9a8c\u4e2d\uff0c\u767e\u6cfd\u5b89&reg;\u8054\u5408\u5316\u7597\u663e\u8457\u5ef6\u957f\u4e86\u65e2\u5f80\u672a\u7ecf\u6cbb\u7597\u7684RM-NPC\u60a3\u8005\u7684PFS\uff0c\u5728\u5404\u60a3\u8005\u4e9a\u7ec4\u4e2d\u89c2\u5bdf\u5230\u7684\u751f\u5b58\u83b7\u76ca\u4e00\u81f4\u3002RM-NPC\u662f\u4e9a\u6d32\u5e38\u89c1\u7684\u4fb5\u88ad\u6027\u5934\u9888\u90e8\u80bf\u7624\u3002\u4e24\u7ec4\u7684\u5b89\u5168\u6027\u7ed3\u679c\u5747\u4e0e\u5df2\u77e5\u98ce\u9669\u76f8\u4f3c\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u8fd9\u4e9b\u9f13\u821e\u4eba\u5fc3\u7684\u7ed3\u679c\u8bc1\u5b9e\u4e86\u767e\u6cfd\u5b89&reg;\u8054\u5408\u5316\u7597\u5728\u4e2d\u56fd\u4f5c\u4e3aRM-NPC\u4e00\u7ebf\u6cbb\u7597\u65b0\u6807\u51c6\u7597\u6cd5\u7684\u6f5c\u529b\u3002\u201d \u622a\u81f32021\u5e743\u670826\u65e5\uff0cRATIONALE 309\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a10\u4e2a\u6708\uff0c\u5728\u671f\u4e2d\u5206\u6790\u65f6\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\uff0c\u6839\u636eIRC\u7684\u8bc4\u4f30\uff0c\u4e0e\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u76f8\u6bd4\uff0c\u767e\u6cfd\u5b89&reg;\u8054\u5408\u5316\u7597\u53ef\u6539\u5584PFS\uff0c\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u3002\u8bd5\u9a8c\u6709\u6548\u6027\u7ed3\u679c\u5982\u4e0b\uff1a&nbsp; \u6839\u636eIRC\u7684\u8bc4\u4f30\uff0cA\u7ec4\u7684\u4e2d\u4f4dPFS\u4e3a9.2\u4e2a\u6708\uff0895% CI\uff1a7.6\uff0c10.1\uff09\uff0cB\u7ec4\u4e3a7.4\u4e2a\u6708\uff0895% CI\uff1a5.6\uff0c7.5\uff09\uff0c\u5206\u5c42\u98ce\u9669\u6bd4\uff08HR\uff09\u4e3a0.52\uff0895% CI\uff1a0.38\uff0c0.73\uff09\uff0c\u5206\u5c42log-rank\u68c0\u9a8cp\u503c&lt;&nbsp;0.0001\uff1b \u6839\u636eIRC\u7684\u8bc4\u4f30\uff0cA\u7ec4\u57286\u30019\u548c12\u4e2a\u6708\u65f6\u7684PFS\u7387\u5206\u522b\u4e3a66.1%\uff0895% CI\uff1a56.9\uff0c73.8\uff09\u300151.0%\uff0895% CI\uff1a41.1\uff0c60.1\uff09\u548c35.7%\uff0895% CI\uff1a25.2\uff0c46.4\uff09\uff0cB\u7ec4\u5206\u522b\u4e3a53.0%\uff0895% CI\uff1a43.4\uff0c61.8\uff09\u300121.6%\uff0895% CI\uff1a13.5\uff0c30.9\uff09\u548c12.2%\uff0895% CI\uff1a5.6\uff0c21.4\uff09\uff1b \u6839\u636e\u7814\u7a76\u8005\u7684\u8bc4\u4f30\uff0cA\u7ec4\u7684\u4e2d\u4f4dPFS\u4e3a9.8\u4e2a\u6708\uff0895% CI\uff1a7.8\uff0c11.9\uff09\uff0cB\u7ec4\u4e3a7.6\u4e2a\u6708\uff0895% CI\uff1a6.6\uff0c7.8\uff09\uff0c\u5206\u5c42HR\u4e3a0.54\uff0895% CI\uff1a0.38\uff0c0.76\uff09\uff1b \u5728\u5927\u591a\u6570\u4e9a\u7ec4\u4e2d\u89c2\u5bdf\u5230\u7684PFS\u83b7\u76ca\u4e00\u81f4\uff0c\u5305\u62ec\u75be\u75c5\u72b6\u6001\u3001\u57fa\u7ebf\u809d\u8f6c\u79fb\u548c\u6027\u522b\u4e9a\u7ec4\uff1b \u6839\u636eIRC\u7684\u8bc4\u4f30\uff0cA\u7ec4\u7684ORR\u548c\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u7387\u5206\u522b\u4e3a69.5%\u548c16.0%\uff0cB\u7ec4\u5206\u522b\u4e3a55.3%\u548c6.8%\uff1b \u6839\u636eIRC\u7684\u8bc4\u4f30\uff0cA\u7ec4\u7684\u4e2d\u4f4dDoR\u4e3a8.5\u4e2a\u6708\uff0895% CI\uff1a6.5\uff0c\u4e0d\u53ef\u4f30\u8ba1\uff09\uff0cB\u7ec4\u4e3a6.1\u4e2a\u6708\uff0895% CI\uff1a4.7\uff0c6.2\uff09\u3002 \u767e\u6cfd\u5b89&reg;\u8054\u5408\u5316\u7597\u7684\u5b89\u5168\u6027\u7279\u5f81\u53ef\u63a7\uff0c\u4e14\u4e0e\u6bcf\u79cd\u6cbb\u7597\u836f\u7269\u7684\u5df2\u77e5\u98ce\u9669\u4e00\u81f4\u3002\u8bd5\u9a8c\u5b89\u5168\u6027\u7ed3\u679c\u5982\u4e0b\uff1a A\u7ec4\u7684\u6240\u6709\u60a3\u8005\uff08100%\uff09\u5747\u53d1\u751f\u81f3\u5c111\u4f8b\u4efb\u4f55\u7ea7\u522b\u7684\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\uff0c\u6700\u5e38\u89c1\u7684\uff08\u53d1\u751f\u7387\u2265&nbsp;20.0%\uff09\u4e3a\u8d2b\u8840\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u6076\u5fc3\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u964d\u4f4e\u3001\u98df\u6b32\u51cf\u9000\u3001\u5455\u5410\u3001\u4fbf\u79d8\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u76ae\u75b9\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\u3001\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08ALT\uff09\u5347\u9ad8\u3001\u4f4e\u94a0\u8840\u75c7\u3001\u8840\u808c\u9150\u5347\u9ad8\u3001\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08AST\uff09\u5347\u9ad8\u3001\u96be\u53d7\u548c\u53d1\u70ed\uff1b \u76f8\u6bd4\u4e4b\u4e0b\uff0cB\u7ec4\u4e2d\u6709131\u4f8b\u60a3\u8005\uff0899.2%\uff09\u53d1\u751f\u81f3\u5c111\u4f8b\u4efb\u4f55\u7ea7\u522b\u7684TEAE\uff0c\u6700\u5e38\u89c1\u7684\uff08\u53d1\u751f\u7387\u2265&nbsp;20.0%\uff09\u4e3a\u8d2b\u8840\u3001\u6076\u5fc3\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u964d\u4f4e\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u5455\u5410\u3001\u98df\u6b32\u51cf\u9000\u3001\u4fbf\u79d8\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u4f4e\u94a0\u8840\u75c7\u3001\u96be\u53d7\u3001\u4f4e\u94be\u8840\u75c7\u3001\u76ae\u75b9\u3001AST\u5347\u9ad8\u548c\u4f4e\u767d\u86cb\u767d\u8840\u75c7\uff1b A\u7ec4\u4e2d\u6709106\u4f8b\u60a3\u8005\uff0880.9%\uff09\u53d1\u751f\u4e86\u2265&nbsp;3\u7ea7TEAE\uff0cB\u7ec4\u4e2d\u6709108\u4f8b\u60a3\u8005\uff0881.8%\uff09\u53d1\u751f\u4e86\u2265&nbsp;3\u7ea7TEAE\uff1b A\u7ec4\u4e2d\u670936\u4f8b\u60a3\u8005\uff0827.5%\uff09\u53d1\u751f\u4e86\u4e25\u91cdTEAE\uff0cB\u7ec4\u4e2d\u670944\u4f8b\u60a3\u8005\uff0833.3%\uff09\u53d1\u751f\u4e86\u4e25\u91cdTEAE\uff1b A\u7ec4\u4e2d\u5206\u522b\u67092\u4f8b\u60a3\u8005\uff081.5%\uff09\u548c5\u4f8b\u60a3\u8005\uff083.8%\uff09\u53d1\u751f\u4e86\u5bfc\u81f4\u6c38\u4e45\u7ec8\u6b62\u6cbb\u7597\u548c\u6b7b\u4ea1\u7684TEAE\uff0cB\u7ec4\u4e2d\u5206\u522b\u67093\u4f8b\u60a3\u8005\uff082.3%\uff09\u548c2\u4f8b\u60a3\u8005\uff081.5%\uff09\u53d1\u751f\u4e86\u5bfc\u81f4\u6c38\u4e45\u7ec8\u6b62\u6cbb\u7597\u548c\u6b7b\u4ea1\u7684TEAE\uff1b A\u7ec4\u4e2d\u670924\u4f8b\u60a3\u8005\uff0818.3%\uff09\u53d1\u751f\u81f3\u5c111\u4f8b\u4efb\u4f55\u7ea7\u522b\u7684\u514d\u75ab\u4ecb\u5bfc\u6027TEAE\uff0c\u5176\u4e2d3\u4f8b\u60a3\u8005\uff082.3%\uff09\u53d1\u751f\u4e86\u2265&nbsp;3\u7ea7\u4e8b\u4ef6\u3002 \u5173\u4e8e\u9f3b\u54bd\u764c \u9f3b\u54bd\u764c\uff08NPC\uff09\u662f\u4e00\u79cd\u6076\u6027\u9cde\u72b6\u7ec6\u80de\u764c\uff0c\u8d77\u6e90\u4e8e\u9f3b\u54bd\u7684\u4e0a\u76ae\u7ec6\u80de\uff0c\u6700\u5e38\u89c1\u4e8e\u54bd\u9690\u7a9d1\u30022020\u5e74\uff0c\u4e2d\u56fd\u7ea6\u670962,555\u4f8b\u65b0\u589eNPC\u60a3\u8005\uff0c\u5360\u5168\u7403\u65b0\u53d1\u75c5\u4f8b\u768446.8%2\u3002\u5c3d\u7ba1NPC\u5bf9\u4e2d\u56fd\u5357\u65b9\u548c\u5176\u4ed6\u75be\u75c5\u6d41\u884c\u5730\u533a\u7684\u516c\u5171\u536b\u751f\u9020\u6210\u4e86\u6c89\u91cd\u8d1f\u62c5\uff0c\u4f46\u5927\u4f17\u5bf9NPC\u7684\u75c5\u56e0\u4ee5\u53ca\u5982\u4f55\u9884\u9632\u77e5\u4e4b\u8f83\u5c113\u3002NPC\u7684\u4e3b\u8981\u98ce\u9669\u56e0\u7d20\u662f\u9057\u4f20\u6613\u611f\u6027\u3001Epstein-Barr\u75c5\u6bd2\uff08EBV\uff09\u611f\u67d3\u548c\u98df\u7528\u76d0\u814c\u98df\u72694\u3002\u665a\u671fNPC\u60a3\u8005\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u7ea6\u4e3a20\u4e2a\u67085\uff1b\u636e\u62a5\u9053\uff0c\u590d\u53d1\u6216\u8f6c\u79fb\u6027NPC\u60a3\u8005\u7684\u9884\u540e\u901a\u5e38\u9010\u6e10\u6076\u5316\uff0c3\u5e74\u751f\u5b58\u7387\u964d\u81f3\u7ea67% ~ 40%\uff0c\u8fd9\u8868\u660eNPC\u4ecd\u5b58\u5728\u5927\u91cf\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\uff0c\u4e9f\u9700\u66f4\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5&nbsp;6,7,8\u3002 \u5173\u4e8e\u767e\u6cfd\u5b89&reg;\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2021121015000056038\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-56038","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/56038","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=56038"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/56038\/revisions"}],"predecessor-version":[{"id":56039,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/56038\/revisions\/56039"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=56038"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=56038"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=56038"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}